RNAi

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 6195
  • Symbol: RPS6KA1
  • Description: ribosomal protein S6 kinase A1
DataSource: http://genomernai.dkfz.de/v16/genedetails/6195

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Stable_ID Entrez_ID Gene_ID Gene_Symbol Reagent_ID Score Phenotype Conditions Follow_Up Comment Screen_Title Publication_Title Authors Publication_Year Pubmed_ID Biosource Biomodel Assay Method Library Scope Reagent_Type Score_Type Cutoff Notes
GR00016-A 6195 6195 RPS6KA1 np 1.29 none no Wnt/beta-catenin pathway regulation Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. James et al. 2009 19471023 Cell line RKO Wnt/beta-catenin pathway reporter Luminescence rp Selected genes siRNA Z-score > 2
GR00053-A 6195 NM_002953 RPS6KA1 np sp none no Genome stability A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Paulsen et al. 2009 19647519 Cell line HeLa gamma-H2AX phosphorylation and DNA content Fluorescence siARRAY human genome siRNA library Genome-wide siRNA p-value Complex criteria Confidence groupings from 4 to 1 (highest level of confidence in group 4)
GR00054-A 6195 NM_002953 RPS6KA1 np 0.915 none no Combinatorial effect with paclitaxel Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Whitehurst et al. 2007 17429401 Cell line NCI-H1155 Viability (synthetic lethal) ATP level # G-005000-01 Genome-wide siRNA Paclitaxel/control ratio Complex criteria Additional information about 87 high-confidence hits
6195 6195 RPS6KA1 np np Decreased cell migration yes deconvoluted validated siRNAs: 1/4
GR00055-A-3 6195 6195 RPS6KA1 np np Increased cell migration no Epithelial cell migration (3) Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Simpson et al. 2008 19160483 Cell line MCF-10A overexpressing ERBB2 Cell migration and viability Microscopy and fluorescence SMARTpool siRNA library and MAR library Selected genes siRNA Area score and Alamar score Complex criteria
GR00056-A 6195 NM_002953 RPS6KA1 np 0.814 none no Melanogenesis Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. Ganesan et al. 2008 19057677 Cell line MNT-1 Melanin protein expression and viability Absorbance and luminescence rp Genome-wide siRNA Normalized absorbance ratio > 2 standard deviations below mean Additional information about a secondary screen (retest to determine false-positive rate)
GR00057-A-1 6195 NM_002953 RPS6KA1 M-003025-03 -0.08 none no Wnt/beta-catenin pathway regulation (1) A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Tang et al. 2008 18621708 Cell line HeLa Wnt pathway reporter Luminescence Human siArray siRNA library Genome-wide siRNA Z-score > 4 Screen without Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00057-A-2 6195 NM_002953 RPS6KA1 M-003025-03 sp none no Wnt/beta-catenin pathway regulation (2) A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Tang et al. 2008 18621708 Cell line HeLa Wnt pathway reporter Luminescence Human siArray siRNA library Genome-wide siRNA Complex, SP Complex criteria Screen with Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries).
GR00095-A 6195 NM_002953 RPS6KA1 np np none p53 pathway components A large-scale RNAi screen in human cells identifies new components of the p53 pathway Berns et al. 2004 15042092 Cell line BJ-TERT-tsLT fibroblasts Proliferation Colony-forming cell assay Nki library Genome-wide shRNA np np
GR00098-A-1 6195 ENSG00000117676 RPS6KA1 ENSG00000117676 sp none no Cell division (1) Genome-scale RNAi profiling of cell division in human tissue culture cells. Kittler et al. 2007 17994010 Cell line HeLa Cell number and DNA content Laser scanning cytometry rp Genome-wide esiRNA Complex, sp Complex criteria
GR00101-A-1 6195 NM_002953 RPS6KA1 np np Synthetic lethal with cisplatin yes Combinatorial effect with anticancer drugs (1): cisplatin Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions. Bartz et al. 2006 17000754 Cell line HeLa Viability (synthetic lethal) Alamar Blue rp Selected genes siRNA log2 ratio 2 standard deviations from mean ratio Additional information about the primary genome-wide screen
GR00101-A-2 6195 NM_002953 RPS6KA1 np np none yes Combinatorial effect with anticancer drugs (2): gemcitabine Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions. Bartz et al. 2006 17000754 Cell line HeLa Viability (synthetic lethal) Alamar Blue rp Selected genes siRNA log2 ratio 2 standard deviations from mean ratio Additional information about the primary genome-wide screen
GR00101-A-3 6195 NM_002953 RPS6KA1 np np none no Combinatorial effect with anticancer drugs (3): paclitaxel Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions. Bartz et al. 2006 17000754 Cell line HeLa Viability (synthetic lethal) Alamar Blue rp Selected genes siRNA log2 ratio 1.7 standard deviations from mean ratio Additional information about the primary genome-wide screen
GR00103-A-0 6195 RPS6KA1 v2HS_32013 -1.15 Increased cell death HMECs cells no Cell viability Cancer proliferation gene discovery through functional genomics. Schlabach et al. 2008 18239126 Cell line DLD-1, HCT116; HCC1954; HMECs (mammary epithelia cells) Cell viability Micoarray hybridization shRNA-mir (G. Hannon) shRNA log ratio <
GR00114-A 6195 RPS6KA1 np -1.14 none 79% Combinatorial effect with Poly (ADP‐ribose)‐polymerase‐1 (PARP) A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. Turner et al. 2008 18388863 Cell line CAL51 Viability Luminescence siARRAY SMARTpool Kinases siRNA Z-score < Growth rates (%) for vehicle-alone experiments are given in the comment field.
GR00121-A 6195 RSK3 TRCN0000001384 40.63 Decreased viability in Von Hippel-Lindau (VHL) (-/-) cell line Combinatorial effect with Von Hippel-Lindau (VHL) Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen. Bommi-Reddy et al. 2008 18948595 Cell line 786-O Viability Colorimetric lentiviral library Kinases shRNA Differential loss of viability (%) > Additional screen in RCC4 cells available
GR00123-A 6195 NM_002953 RPS6KA1 102102, 102103, 102101 np none Combinatorial effect with nutlin-3 An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors Brummelkamp et al. 2006 16474381 Cell line MCF-7 Viability Fluoresence Nki library Genome-wide shRNA log2 ratio np
GR00133-A-1 6195 6195 RPS6KA1 np -0.002583 none no Salmonella enterica subspecies 1 serovar Typhimurium invasion (1) RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. Misselwitz et al. 2011 21407211 Cell line HeLa Gentamycin protection invasion assay Fluorescence Druggable genome library V2.0 Druggable genes siRNA log2 median Complex criteria
GR00143-A 6195 RPS6KA1 RPS6KA1 s1 sp none no tau phosphorylation High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. Azorsa et al. 2010 20067632 Cell line H4 overexpressing 4RON tau Total tau and 12E8 tau protein expression Fluorescence Validated human kinase siRNA Set 2.0 Kinases siRNA p-value Complex criteria
GR00143-A 6195 RPS6KA1 RPS6KA1 s2 sp none no tau phosphorylation High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. Azorsa et al. 2010 20067632 Cell line H4 overexpressing 4RON tau Total tau and 12E8 tau protein expression Fluorescence Validated human kinase siRNA Set 2.0 Kinases siRNA p-value Complex criteria
GR00151-A-1 6195 ENSG00000117676 RPS6KA1 np -0.359 none no Homologous recombination DNA double-strand break repair (HR-DSBR) (1) A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. SÅ‚abicki et al. 2010 20613862 Cell line HeLa (HR-DSBR) DR-GFP reporter Flow cytometry Custom-made Genome-wide esiRNA Z-score < -2 OR > 2
GR00155-A 6195 6195 RPS6KA1 RPS6KA1_1, RPS6KA1_2, RPS6KA1_3 np none no Aryl hydrocarbon receptor (AhR) transduction pathway regulation RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity. Gilot et al. 2011 21479225 Cell line MCF-7 TCDD-induced CYP1A1-related EROD activity and cell viability Fluorescence and methylene blue MISSION siRNA Human Kinase Panel library Kinases siRNA Z-score Top 150 for >
GR00180-A-1 6195 6195 RPS6KA1 PL-50003 0.909 none no Hepatitis C virus replication (1) A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Tai et al. 2009 19286138 Cell line Huh7/Rep-Feo HCV replicon RNA copy number Luminescence siARRAY Human Genome siRNA Library Genome-wide siRNA q-value Complex criteria
GR00184-A-1 6195 NM_002953 RPS6KA1 M-003025-03 -0.795605012179984 none no Self-renewal and pluripotency in human embryonic stem cells (1) A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Chia et al. 2010 20953172 Cell line hESC H1 POU5F1 protein expression Fluorescence SMARTpool siRNA library Genome-wide siRNA Z-score < -2
GR00193-A-1 6195 6195 RPS6KA1 RPS6KA1 np none yes Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (1) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line EBC1 Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00193-A-2 6195 6195 RPS6KA1 RPS6KA1 0.496 Decreased substrate adherent cell growth yes Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (2) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line KELLY Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00193-A-3 6195 6195 RPS6KA1 RPS6KA1 0.934942464310609 none yes Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (3) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line SKNAS Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00193-A-4 6195 6195 RPS6KA1 RPS6KA1 0.495 Decreased substrate adherent cell growth no Illumina gene expression above basal level (p < 0.05) Therapeutic kinase targets in neuroblastoma (4) RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Cole et al. 2011 21289283 Cell line NLF Substrate adherent cell growth rp Kinase siGenome library Kinases siRNA Relative growth 0.5 standard deviations below mean
GR00196-A-1 6195 ENSG00000117676 np sp none no TP53 interactions (1) A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly. Krastev et al. 2011 21642980 Cell line HCT116 ( wildtype and TP53 knockout) TP53 protein expression and viability Fluorescence rp Genome-wide esiRNA Complex, sp Complex criteria
GR00197-A-1 6195 6195 RPS6KA1 M-003025-03 0.171999602 none no Human papillomavirus oncogene expression regulation (1) Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Smith et al. 2010 20133580 Cell line C33A/BE2/18LCR c4 HPV18 LCR reporter activity Luminescence Human siGENOME SMARTpool library Genome-wide siRNA Z-score > Author-submitted data. Phenotype strength according to Z-scores: weak: 2 - 3; moderate: 3 - 5; strong: > 5
GR00210-A 6195 6195 RPS6KA1 np sp none no Focal adhesion formation Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown. Winograd-Katz et al. 2009 19667130 Cell line HeLa paxillin protein expression Fluorescence SMARTpool siARRAY siRNA Libraries Kinases, phosphatases and selected genes siRNA Z-score > 3.5 OR < -3.5
GR00221-A-1 6195 RPS6KA1 TRCN0000039755 -1.09 Decreased viability yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 6195 RPS6KA1 TRCN0000039756 -0.35 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 6195 RPS6KA1 TRCN0000001385 -0.2 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 6195 RPS6KA1 TRCN0000039754 -0.02 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 6195 RPS6KA1 TRCN0000001384 0.71 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 6195 RPS6KA1 TRCN0000001388 0.73 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-1 6195 RPS6KA1 TRCN0000039753 0.91 none yes Proliferation of cells with active beta-catenin (1) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MCF-7 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 6195 RPS6KA1 TRCN0000039754 -1.27 Decreased viability yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 6195 RPS6KA1 TRCN0000001384 -0.64 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 6195 RPS6KA1 TRCN0000001386 -0.45 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 6195 RPS6KA1 TRCN0000001385 -0.22 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 6195 RPS6KA1 TRCN0000039753 -0.07 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 6195 RPS6KA1 TRCN0000001387 -0.05 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-2 6195 RPS6KA1 TRCN0000001388 0.91 none yes Proliferation of cells with active beta-catenin (2) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-231 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 6195 RPS6KA1 TRCN0000001388 -2.14 Decreased viability yes essential gene Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 6195 RPS6KA1 TRCN0000001385 -1.37 Decreased viability yes essential gene Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 6195 RPS6KA1 TRCN0000001386 -1.07 Decreased viability yes essential gene Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 6195 RPS6KA1 TRCN0000001384 0.27 none yes essential gene Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 6195 RPS6KA1 TRCN0000039754 0.29 none yes essential gene Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 6195 RPS6KA1 TRCN0000001387 0.55 none yes essential gene Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-3 6195 RPS6KA1 TRCN0000039753 1.4 none yes essential gene Proliferation of cells with active beta-catenin (3) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line MDA-MB-453 Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 6195 RPS6KA1 TRCN0000039757 -1.77 Decreased viability no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 6195 RPS6KA1 TRCN0000039753 -1.09 Decreased viability no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 6195 RPS6KA1 TRCN0000001386 -0.84 none no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 6195 RPS6KA1 TRCN0000001385 -0.65 none no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 6195 RPS6KA1 TRCN0000039755 -0.35 none no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 6195 RPS6KA1 TRCN0000001387 -0.18 none no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 6195 RPS6KA1 TRCN0000001384 0.06 none no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 6195 RPS6KA1 TRCN0000001388 0.47 none no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00221-A-4 6195 RPS6KA1 TRCN0000039754 0.79 none no essential gene Proliferation of cells with active beta-catenin (4) CK1epsilon is required for breast cancers dependent on beta-catenin activity. Kim et al. 2010 20126544 Cell line T47D Viability Luminescence TRC shRNA Library Kinases shRNA B-score < -1 Essential gene: gene with B-score < -1 for >
GR00225-A 6195 RPS6KA1 RPS6KA1_A -0.737316 none 10nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
GR00225-A 6195 RPS6KA1 RPS6KA1_B -0.696334 none 10nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
GR00225-A 6195 RPS6KA1 RPS6KA1_A -0.147583 none 5nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
GR00225-A 6195 RPS6KA1 RPS6KA1_B -0.238589 none 5nM gemcitabine no Combinatorial effect with gemcitabine Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. Azorsa et al. 2009 19519883 Cell line MIAPaCa-2 Viability (synthetic lethal) Luminescence Validated kinase siRNA library version 1.0 Kinases siRNA log2 ratio 1.65 SD below mean ratio level
6195 NM00100666 RPS6KA1 np 1.052748 none no
GR00230-A-1 6195 NM_002953 RPS6KA1 TRCN0000001384 3.73 Increased cell viability after pRB stimulation yes pRB-induced cell cycle regulation (1) A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Tschöp et al. 2011 21498571 Cell line SaOS2-TR-pRB Cell number and viability Colorimetrics Lentiviral shRNA library Kinases shRNA SD from the trendline > 3.0 OR < -3.0 for >
GR00230-A-1 6195 NM_002953 RPS6KA1 TRCN0000001387 3.36 Increased cell viability after pRB stimulation yes pRB-induced cell cycle regulation (1) A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Tschöp et al. 2011 21498571 Cell line SaOS2-TR-pRB Cell number and viability Colorimetrics Lentiviral shRNA library Kinases shRNA SD from the trendline > 3.0 OR < -3.0 for >
GR00230-A-1 6195 NM_002953 RPS6KA1 TRCN0000001388 4.01 Increased cell viability after pRB stimulation yes pRB-induced cell cycle regulation (1) A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Tschöp et al. 2011 21498571 Cell line SaOS2-TR-pRB Cell number and viability Colorimetrics Lentiviral shRNA library Kinases shRNA SD from the trendline > 3.0 OR < -3.0 for >
GR00231-A 6195 NM_002953 RPS6KA1 M-003025-03 -1.105 none yes Cell proliferation Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation. Zhang et al. 2011 21765947 Cell line HeLa Viability Electrical impedance Human siARRAY - Protein Kinase and Cell Cycle libraries Kinases and selected genes siRNA Z-score < -1.96 OR > 1.96 Additional information about cell titer blue cell viability screen
GR00234-A-1 6195 NM_002953 RPS6KA1 np sp none no decreased vesicular stomatitis virus pseudoparticles (VSVpp) infection Hepatitis C virus (HCV) infection (1) EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Lupberger et al. 2011 21516087 Cell line Huh7 Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) protein expression Luminescence Human Kinase RNAi Set V2.0 Kinases siRNA Complex, sp Complex criteria
GR00236-A-1 6195 6195 RPS6KA1 M-003025-03 1.38483011448601 none no Homologous recombination DNA double-strand break repair (HR-DSBR) (1) A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Adamson et al. 2012 22344029 Cell line DR-U2OS (HR-DSBR) DR-GFP reporter and DNA content Fluorescence Human siGENOME siRNA (G-005000-05) Genome-wide siRNA Relative HR ratio < ~0.4 OR > 1.88 Cutoff values correspond 2 standard deviations from the screen-wide mean
GR00240-S-1 6195 NM_002953 RPS6KA1 M-003025-03 0.85 none yes TRAIL-induced apoptosis (1) A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. Kranz and Boutros 2014 24442637 Cell line U251MG Viability Luminescence SMART-pool siRNA Genome-wide siRNA Z-score > 4 Author-submitted data
GR00240-S-2 6195 NM_002953 RPS6KA1 M-003025-03 -1.21 none no Z-score -0.3775 TRAIL-induced apoptosis (2) A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. Kranz and Boutros 2014 24442637 Cell line U251MG Viability (synthetic lethal) Luminescence SMART-pool siRNA Genome-wide siRNA Differential score > 3.6 AND viability Z-score < 4 Author-submitted data. Z-scores from viability screen (1) are considered in score interpretation for this screen.
GR00242-A-1 6195 NM_002953 RPS6KA1 np sp none no Selective autophagy regulation (1) Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl et al. 2011 22020285 Cell line HeLa/GFP-LC3 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression Fluorescence siGenome Genome-wide siRNA Z-score Complex criteria
GR00247-A-1 6195 RPS6KA1 np sp none rank: 815 Regulation of FOXO1 nuclear localization (1) Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. Senapedis et al. 2011 21460183 Cell line U2OS EGFP-FOXO1a protein expression and DNA content Fluorescence Human Genome library Genome-wide siRNA Complex, sp Complex criteria
GR00248-A 6195 NM_002953 RPS6KA1 RPS6KA1_siRNA1 -1.293 none Human cytomegalovirus (HCMV) strain AD169 replication Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Terry et al. 2012 22315427 Cell line MRC5 Human cytomegalovirus (HCMV) IE1 protein expression Fluorescence Mission siRNA Human Kinase Panel Kinases siRNA Z-score >
GR00248-A 6195 NM_002953 RPS6KA1 RPS6KA1_siRNA2 -1.803 none Human cytomegalovirus (HCMV) strain AD169 replication Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Terry et al. 2012 22315427 Cell line MRC5 Human cytomegalovirus (HCMV) IE1 protein expression Fluorescence Mission siRNA Human Kinase Panel Kinases siRNA Z-score >
GR00248-A 6195 NM_002953 RPS6KA1 RPS6KA1_siRNA3 2.603 Increased human cytomegalovirus (HCMV) strain AD169 replication Human cytomegalovirus (HCMV) strain AD169 replication Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Terry et al. 2012 22315427 Cell line MRC5 Human cytomegalovirus (HCMV) IE1 protein expression Fluorescence Mission siRNA Human Kinase Panel Kinases siRNA Z-score >
GR00249-S 6195 6195 RPS6KA1 J-003025-13 -0.31617 none no number of cells compared to control (%): 72.82 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 6195 6195 RPS6KA1 M-003025-04 -0.15807 none no number of cells compared to control (%): 78.50 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 6195 6195 RPS6KA1 s12273 0.24569 none no number of cells compared to control (%): 86.11 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 6195 6195 RPS6KA1 s12274 -0.70812 none no number of cells compared to control (%): 86.68 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00249-S 6195 6195 RPS6KA1 s12275 1.03417 Increased vaccinia virus (VACV) infection no number of cells compared to control (%): 51.16 Vaccinia virus (VACV) infection Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. Sivan et al. 2013 23401514 Cell line HeLa Vaccinia virus VACV IHD-J/GFP protein expression and DNA content Fluorescence Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus Genome-wide siRNA Z-score > Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %.
GR00253-A 6195 NM_002953 RPS6KA1 np -3.169 Decreased hepcidin::fluc mRNA expression hepcidin regulation Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Mleczko-Sanecka et al. 2014 24385536 Cell line Huh7 hepcidin::fluc mRNA expression Luminescence siGenome siARRAY SMARTpool Genome-wide siRNA Z-score > Cutoff <
GR00255-A-1 6195 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001387, TRCN0000001388, TRCN0000010426, TRCN0000010427, TRCN0000039753, TRCN0000039754, TRCN0000039755, TRCN0000039757 -0.185073002 none Negative genetic interactions (1) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.0 HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-2 6195 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001387, TRCN0000001388, TRCN0000010426, TRCN0000010427, TRCN0000039753, TRCN0000039754, TRCN0000039755, TRCN0000039757 -0.384183365 none Negative genetic interactions (2) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.0 HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-3 6195 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001387, TRCN0000001388, TRCN0000010426, TRCN0000010427, TRCN0000039753, TRCN0000039754, TRCN0000039755, TRCN0000039757 0.378337636 none Negative genetic interactions (3) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.2 HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-4 6195 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001387, TRCN0000001388, TRCN0000010426, TRCN0000010427, TRCN0000039753, TRCN0000039754, TRCN0000039755, TRCN0000039757 0.543908109 none Negative genetic interactions (4) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -1.2 HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00255-A-5 6195 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001387, TRCN0000001388, TRCN0000010426, TRCN0000010427, TRCN0000039753, TRCN0000039754, TRCN0000039755, TRCN0000039757 0.338140337 none Negative genetic interactions (5) A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar et al. 2013 24104479 Cell line HCT116 shRNA abundance Microarray np Genome-wide shRNA differential Gene Activity Ranking Profile (dGARP) < -0.8 HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells)
GR00256-A 6195 NM_002953, NM_001006665 RPS6KA1 np sp none Kinase-mediated spindle orientation ABL1 regulates spindle orientation in adherent cells and mammalian skin. Matsumara et al. 2012 22252550 Cell line HeLa beta-tubulin protein expression and DNA content Fluorescence Silencer Kinase siRNA library (AM80010V3) Kinases siRNA Complex, sp Complex criteria HeLa cells stably expressing GFP-H2B (HeLa-GH2B) used. Additional information about secondary screens.
GR00293-A 6195 RPS6KA1 np 0.414 none Combinatorial effect with paclitaxel Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death Sinnott et al. 2014 24860162 Cell line HCC366 Viability Luminescence Thermo-Fisher Genome-wide siRNA Z-score < -2.5 Final hits according to the author are indicated in the comment.
GR00300-A 6195 RPS6KA1 TRCN0000010426, TRCN0000199052, TRCN0000199439, TRCN0000039756, TRCN0000001387, TRCN0000039755, TRCN0000001388, TRCN0000039754, TRCN0000001385, TRCN0000001386, TRCN0000039757, TRCN0000199769, TRCN0000001384, TRCN0000199383 0 none Combinatorial effect with RAF inhibitor PLX4720 A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. Whittaker et al. 2013 23288408 Cell line A375 shRNA abundance Sequencing TRC Genome-wide shRNA Number of shRNAs ranked Top1000 > 2 The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors.
6195 NM_002953 RPS6KA1 NM_002953.x-957s1c1 -2.79 Decreased viability
GR00303-A 6195 NM_002953 RPS6KA1 np 1.08 none Clear cell renal cell carcinoma (ccRCC) survival regulation Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target Gerlinger et al. 2012 22362593 Cell line VHL-deficient RCC4 Proliferation and Viability Fluorescence np Genome-wide siRNA Z-score < In the phenotype data duplicates were in the original document, which have been removed.
GR00310-A-1 6195 6195 RPS6KA1 np -1.75 none Sindbis virus (SINV) infection (1) Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry Ooi et al. 2013 24367265 Cell line U2OS Sindbis virus (SINV) reporter Luminescence Ambion Silencer V3 Genome-wide siRNA Z-score < -3 OR > 2
6195 6195 RPS6KA1 np 57 none 74% viability
GR00313-A 6195 NM_001006665, NM_002953 RPS6KA1 np 0.19 none TNF-alpha pathway regulation A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling. Nickles et al. 2012 22733992 Cell line HEK293T NFkappaB pathway reporter Luminescence Qiagen Genome-wide siRNA Z-score < Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%.
GR00318-A 6195 6195 RPS6KA1 np 1.186 none siRNA set: kinase Huntingtin toxicity A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease Miller et al. 2012 23209424 Cell line HEK293T Caspase 3/7 activity Fluorescence Dharmacon Selected genes siRNA Sum of normalized caspase 3/7 activity mean and standard error < 0.683 HEK293T cells were cotransfected with mutant Huntingtin fused to GFP (Htt1-558141Q-GFP).
GR00342-S-1 6195 RPS6KA1 M-003025-03 -1.9133601424881888 Decreased viability Viability of Mesenchymal Stem Cells (MSC) (1) Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Erdmann et al. 2015 26120366 Primary cells Bone marrow derived MSC Viability Luminescence Kinase siGENOME SMARTpool library Kinases and phosphatases siRNA Z-score > Donor 1, MSC preparation 1 (MSC1a)
GR00342-S-2 6195 RPS6KA1 M-003025-03 -0.904864545311775 none Viability of Mesenchymal Stem Cells (MSC) (2) Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Erdmann et al. 2015 26120366 Primary cells Bone marrow derived MSC Viability Luminescence Kinase siGENOME SMARTpool library Kinases and phosphatases siRNA Z-score > Donor 1, MSC preparation 2 (MSC1b)
GR00342-S-3 6195 RPS6KA1 M-003025-03 -0.560841941789196 none Viability of Mesenchymal Stem Cells (MSC) (3) Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening Erdmann et al. 2015 26120366 Primary cells Bone marrow derived MSC Viability Luminescence Kinase siGENOME SMARTpool library Kinases and phosphatases siRNA Z-score > Donor 2, MSC preparation 1 (MSC2)
GR00343-S 6195 6195 RPS6KA1 TRCN0000001387 0.47499999999999964 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6195 6195 RPS6KA1 TRCN0000039753 0.7924999999999986 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6195 6195 RPS6KA1 TRCN0000001388 0.5224999999999973 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6195 6195 RPS6KA1 TRCN0000001384 0.3099999999999987 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6195 6195 RPS6KA1 TRCN0000010426 -0.39000000000000057 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6195 6195 RPS6KA1 TRCN0000039756 -0.21000000000000085 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6195 6195 RPS6KA1 TRCN0000039754 0.20500000000000185 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6195 6195 RPS6KA1 TRCN0000039757 0.3774999999999995 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6195 6195 RPS6KA1 TRCN0000010427 0.9499999999999993 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6195 6195 RPS6KA1 TRCN0000039755 -0.26750000000000007 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6195 6195 RPS6KA1 TRCN0000001386 -1.2125000000000004 shRNA abundance <= 50% Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
GR00343-S 6195 6195 RPS6KA1 TRCN0000001385 -0.35499999999999865 none Lentiviral shRNA "Achilles Heel" screen Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia Cole et al. 2015 26058080 Cell line K562 shRNA abundance Fluorescence Lentiviral shRNA library Genome-wide shRNA Log2 ratio < Comparison of day 21 vs. day 0 abundance data
6195 RPS6KA1 np 1 Resistant to vaccinia virus (VACV-A4L) infection
GR00356-A-1 6195 NM_002953 RPS6KA1 np 0.38 none Clathrin-mediated endocytosis Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Pelkmans et al. 2005 15889048 Cell line HeLa Vesicular stomatitis virus (VSV) infection (rVSV–GFP expression) Fluorescence Ambion Kinases siRNA Relative infection index (RII) < The cutoff was < 0.4 OR > 2.5 if the gene also scored in the additional screen "Caveolin- and lipid raft-mediated endocytosis" using simian virus 40 (SV40).
GR00356-A-2 6195 NM_002953 RPS6KA1 np 0.9649817780923768 none Caveolin- and lipid raft-mediated endocytosis Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Pelkmans et al. 2005 15889048 Cell line HeLa Simian virus 40 (SV40) infection (SV40 large T-antigen expression) Fluorescence Ambion Kinases siRNA Relative infection index (RII) < The cutoff was < 0.4 OR > 2.5 if the gene also scored in the additional screen "Clathrin-mediated endocytosis" using vesicular stomatitis virus (VSV).
GR00356-A-3 6195 NM_002953 RPS6KA1 np np none Endocytosis regulation Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Pelkmans et al. 2005 15889048 Cell line HeLa Transferrin (Tfn) uptake and trafficking Fluorescence Ambion Kinases siRNA np np
GR00363-A 6195 6195 RPS6KA1 355, 354, SI02223060, 356, SI00046102, SI00046116, esi4649, SI02223067 sp Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis strong Endocytosis regulation Systems survey of endocytosis by multiparametric image analysis. Collinet et al. 2010 20190736 Cell line HeLa Transferrin (TF) and epidermal growth factor (EGF) subcellular localisation, DNA content Fluorescence Ambion, Qiagen and esiRNA library (Kittler et al.) Genome-wide siRNA Complex, sp Complex criteria Two hit categories: "strong" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn > 0.95) and "weak but specific" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn < 0.95 but Phenoscore > 0.95). Additional information about secondary screens with kinase and phospatase libraries.
GR00366-A-1 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.42855770830878 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (1) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 22RV1_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-10 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.170457037557768 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (10) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ACHN_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-100 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -1.32454817732116 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (100) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-101 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.246875403250642 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (101) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LK2_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-102 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.334149599292942 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (102) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN215_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-103 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.337503859890189 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (103) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN229_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-104 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.0823260221088492 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (104) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN235_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-105 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.340670197841054 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (105) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN319_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-106 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.0896295561839875 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (106) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN340_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-107 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.185882595343302 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (107) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN382_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-108 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.249711390922166 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (108) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN428_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-109 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -1.13173163022816 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (109) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN443_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-11 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.0918312922904686 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (11) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AGS_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-110 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.347273399651359 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (110) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LN464_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-111 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.523628407942272 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (111) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LNZ308_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-112 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.446613175561132 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (112) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LOVO_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-113 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.253110106970193 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (113) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LS411N_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-114 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.117048765746745 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (114) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line LS513_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-115 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.308045342348172 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (115) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MCF7_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-116 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.09110050807418 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (116) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MDAMB453_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-117 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.939870097163416 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (117) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MIAPACA2_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-118 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.253407157832049 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (118) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MKN7_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-119 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -1.33179508440325 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (119) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-12 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.229469558806577 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (12) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AM38_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-120 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.495562326939332 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (120) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-121 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.334699807113433 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (121) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-122 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.37719605107522 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (122) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-123 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.932175130329091 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (123) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-124 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.159951567181651 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (124) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-125 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.723030070206623 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (125) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-126 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.680177033524302 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (126) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1299_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-127 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.756281527076676 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (127) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1437_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-128 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.515786777000015 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (128) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1650_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-129 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.110166409795293 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (129) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1792_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-13 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.650216978563693 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (13) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-130 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.0254263478602276 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (130) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH196_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-131 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.228527647268089 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (131) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH1975_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-132 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.0248658156531335 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (132) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2052_PLEURA shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-133 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.42371976351779 Increased shRNA abundance (Z-score > 2) RPS6KA1_1_0011111011 Context-specific genetic dependencies (133) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2122_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-134 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.350089055644665 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (134) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2171_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-135 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.15649015678142 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (135) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH23_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-136 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.0014494998047147 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (136) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH2452_PLEURA shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-137 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.519687450128623 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (137) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH441_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-138 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.61427995594905 Increased shRNA abundance (Z-score > 2) RPS6KA1_1_0011111011 Context-specific genetic dependencies (138) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH508_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-139 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.368048774593942 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (139) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH660_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-14 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.0167487019752282 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (14) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ASPC1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-140 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.0388719221476885 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (140) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH661_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-141 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.745724921810925 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (141) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH716_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-142 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.38990317850245 Increased shRNA abundance (Z-score > 2) RPS6KA1_1_0011111011 Context-specific genetic dependencies (142) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIH838_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-143 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.423910485684891 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (143) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NCIN87_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-144 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.989713673592092 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (144) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NIHOVCAR3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-145 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.713188416791898 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (145) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-146 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.722894290442854 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (146) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OAW42_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-147 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.628512700274684 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (147) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-148 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -2.17901002327105 Decreased shRNA abundance (Z-score < -2) RPS6KA1_1_0011111011 Context-specific genetic dependencies (148) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-149 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.458638633071063 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (149) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-15 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.91144071315247 Increased shRNA abundance (Z-score > 2) RPS6KA1_1_0011111011 Context-specific genetic dependencies (15) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BT20_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-150 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.68513141343764 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (150) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OE33_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-151 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.491317365504541 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (151) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OELE_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-152 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.786171986638163 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (152) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-153 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.247424169334047 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (153) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OV7_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-154 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.216595788038771 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (154) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OV90_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-155 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.565284701047307 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (155) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVCAR4_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-156 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.0786592162125754 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (156) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVCAR8_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-157 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.407017342499881 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (157) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line OVISE_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-158 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.93167609669262 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (158) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC0327_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-159 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.41199799892086 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (159) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC0813_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-16 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.540808366096468 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (16) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BT474_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-160 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.206534092566679 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (160) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PANC1005_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-161 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -1.22261959334183 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (161) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-162 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.286363597156607 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (162) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line PSN1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-163 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.00784366132879779 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (163) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line QGP1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-164 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.543048441619764 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (164) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-165 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.209876423655404 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (165) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RKN_SOFT_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-166 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.797932550343966 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (166) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RKO_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-167 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.545712621720743 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (167) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RMGI_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-168 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.0803826667427603 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (168) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RMUGS_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-169 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.979554775865752 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (169) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-17 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.400884779125439 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (17) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line BXPC3_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-170 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.713293819535595 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (170) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line RT112_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-171 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.191961383568321 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (171) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-172 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.0487572261010174 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (172) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF126_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-173 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.241943877735449 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (173) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF172_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-174 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.91689706202467 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (174) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF295_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-175 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.287827254634561 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (175) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SF767_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-176 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.893839355050794 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (176) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SJSA1_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-177 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.510211750359057 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (177) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKCO1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-178 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -1.29146383523093 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (178) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKMEL5_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-179 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -1.13392885193013 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (179) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-18 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.0505832492232756 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (18) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line C2BBE1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-180 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.187651460191817 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (180) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-181 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.289003936346593 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (181) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKOV3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-182 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.0300841663453647 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (182) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SKRC20_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-183 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.0387619283044057 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (183) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR20_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-184 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.874343946625842 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (184) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR21_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-185 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.268132438708844 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (185) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR23_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-186 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.564535364984748 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (186) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR24_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-187 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.248756065099285 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (187) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR25_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-188 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.257590263526964 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (188) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SLR26_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-189 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.368053424332124 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (189) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNU1105_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-19 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.782906977656966 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (19) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line C32_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-190 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.0552550313418964 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (190) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNU840_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-191 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.529493680758156 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (191) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNUC1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-192 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.219303049224338 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (192) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SNUC2A_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-193 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.43082247337193 Increased shRNA abundance (Z-score > 2) RPS6KA1_1_0011111011 Context-specific genetic dependencies (193) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SU8686_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-194 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.112497224388402 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (194) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW1417_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-195 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.49661521367944 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (195) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW1783_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-196 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.451150108767571 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (196) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW480_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-197 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.572884799092685 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (197) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line SW48_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-198 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.742912198511691 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (198) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line T98G_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-199 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.521623037369327 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (199) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TC71_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-2 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.734523834057923 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (2) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-20 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.532648971715974 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (20) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CADOES1_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-200 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.559133046035842 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (200) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TCCSUP_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-201 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.0282254987667735 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (201) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE10_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-202 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.38072225286944 Increased shRNA abundance (Z-score > 2) RPS6KA1_1_0011111011 Context-specific genetic dependencies (202) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE15_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-203 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.141113587539681 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (203) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TE9_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-204 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.582602969606223 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (204) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-205 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.221516858210639 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (205) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TOV112D_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-206 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.0643589449905147 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (206) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TOV21G_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-207 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.62218025242951 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (207) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TT_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-208 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.0665635882554805 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (208) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line TYKNU_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-209 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.856554021574526 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (209) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U178_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-21 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.263277284543443 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (21) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAL120_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-210 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.188686131433775 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (210) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U251MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-211 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.103509049953596 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (211) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U343_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-212 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.467870554127357 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (212) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line U87MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-213 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.000904174888943839 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (213) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line UOK101_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-214 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.124546248635184 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (214) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line VCAP_PROSTATE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-215 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.0436398081334137 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (215) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line YKG1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-216 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.35472709053991 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (216) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line ZR7530_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-22 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.00638866986824438 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (22) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAL51_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-23 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.00234409803874124 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (23) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CALU1_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-24 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.71231982025704 Increased shRNA abundance (Z-score > 2) RPS6KA1_1_0011111011 Context-specific genetic dependencies (24) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAOV3_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-25 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.742542444125428 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (25) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAOV4_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-26 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.406886686905356 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (26) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CAS1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-27 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.189952643948126 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (27) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CFPAC1_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-28 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.44362085134095 Increased shRNA abundance (Z-score > 2) RPS6KA1_1_0011111011 Context-specific genetic dependencies (28) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CH157MN_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-29 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.527921731903844 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (29) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO205_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-3 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.593265911015946 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (3) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line 786O_KIDNEY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-30 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.681522227065559 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (30) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO704_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-31 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.287740463316026 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (31) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO741_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-32 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.105702532951391 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (32) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COLO783_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-33 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.841713062373718 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (33) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line CORL23_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-34 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.38369489847538 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (34) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV362_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-35 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.170016666914774 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (35) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV434_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-36 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.862290924752924 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (36) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV504_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-37 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.26581544183237 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (37) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line COV644_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-38 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.935628375739569 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (38) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DBTRG05MG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-39 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.0975459107012584 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (39) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DKMG_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-4 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.636593623116653 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (4) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A1207_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-40 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.819973490501505 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (40) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line DLD1_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-41 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.709623566276364 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (41) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFE184_ENDOMETRIUM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-42 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.0252983460668641 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (42) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFM19_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-43 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.247272243920044 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (43) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFO21_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-44 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.363971929934174 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (44) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EFO27_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-45 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.217617655296136 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (45) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EW8_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-46 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.677786093646292 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (46) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line EWS502_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-47 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.505552973644331 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (47) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-48 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.839686828094535 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (48) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line GB1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-49 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.17545706700156 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (49) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line GP2D_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-5 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.338979134680915 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (5) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A172_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-50 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.376343045074613 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (50) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1187_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-51 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.737385898509076 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (51) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1395_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-52 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.161360226358088 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (52) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC1954_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-53 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.837291929742112 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (53) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC2218_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-54 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.737071844641537 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (54) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC2814_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-55 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.413250880960166 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (55) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC364_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-56 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.283360675167161 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (56) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC44_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-57 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.399215164077669 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (57) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC70_BREAST shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-58 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.391915434226882 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (58) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC827GR5_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-59 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.30853372145732 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (59) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCC827_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-6 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -1.1268041689256 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (6) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A204_SOFT_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-60 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.29019546435289 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (60) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HCT116_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-61 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.198351999924007 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (61) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HEC1A_ENDOMETRIUM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-62 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.21081156542201 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (62) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HEYA8_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-63 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -1.14503396976922 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (63) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-64 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.33665095150962 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (64) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HLF_LIVER shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-65 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.302357388301051 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (65) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-66 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.387943735197782 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (66) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HPAC_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-67 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.06447102782259 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (67) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HPAFII_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-68 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.596466794812653 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (68) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS683_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-69 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.840038896726988 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (69) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS766T_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-7 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.250279101004437 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (7) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A2058_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-70 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.251438436282999 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (70) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HS944T_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-71 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.576555187268273 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (71) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT1197_URINARY_TRACT shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-72 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.66266159035031 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (72) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT29_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-73 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.290366807385667 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (73) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HT55_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-74 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.618788955213813 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (74) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HUG1N_STOMACH shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-75 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.290098172970203 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (75) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line HUTU80_SMALL_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-76 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.299553878373706 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (76) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IGR39_SKIN shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-77 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.0667642992929046 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (77) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IGROV1_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-78 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.885297512529528 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (78) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line IOMMLEE_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-79 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.153681933670662 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (79) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHESOAD1_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-8 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.308974884185011 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (8) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A549_LUNG shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-80 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.297179181334615 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (80) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHOC5_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-81 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.167976530370794 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (81) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JHOM1_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-82 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.822479268965012 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (82) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-83 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.275191530773511 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (83) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-84 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.554419204302818 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (84) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KALS1_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-85 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.75168157591093 Increased shRNA abundance (Z-score > 2) RPS6KA1_1_0011111011 Context-specific genetic dependencies (85) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-86 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.243899213992497 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (86) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KM12_LARGE_INTESTINE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-87 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.857052097256334 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (87) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-88 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.768360009389029 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (88) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KNS60_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-89 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.462748473222765 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (89) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KNS81_CENTRAL_NERVOUS_SYSTEM shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-9 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.142666280998838 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (9) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line A673_BONE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-90 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 1.00113045767202 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (90) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP1NL_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-91 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.718602374776362 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (91) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP2_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-92 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.0832879855858544 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (92) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KP4_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-93 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -0.615989076705883 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (93) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KURAMOCHI_OVARY shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-94 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.782942569749946 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (94) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE150_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-95 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.948174472192954 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (95) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE30_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-96 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.324406211680653 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (96) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE450_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-97 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.481132073920945 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (97) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line KYSE510_OESOPHAGUS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-98 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 0.455001901011196 none RPS6KA1_1_0011111011 Context-specific genetic dependencies (98) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line L33_PANCREAS shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
GR00366-A-99 6195 RPS6KA1 TRCN0000001384, TRCN0000001385, TRCN0000001386, TRCN0000001388, TRCN0000010426, TRCN0000221516, TRCN0000221517 -1.87027496126527 Decreased shRNA abundance (Z-score < -2) RPS6KA1_1_0011111011 Context-specific genetic dependencies (99) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies Cowley et al. 2014 25984343 Cell line L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE shRNA abundance Next-generation sequencing TRC shRNA Genome-wide Fold change np (default cutoff applied: Z-score > 2 OR < -2) Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.)
6195 6195 RPS6KA1 0.010000000000000009 none
GR00371-A-1 6195 6195 RPS6KA1 0.956547846019 none Dharmacon Nanog expression in absence of bFGF and TGFbeta Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-2 6195 RPS6KA1 6195 -0.203206112431 none Dharmacon Nanog expression in presence of TGFbeta inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-3 6195 6195 RPS6KA1 1.01395736782 none Dharmacon Nanog expression in presence of MEK inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-4 6195 6195 RPS6KA1 0.0425668887773 none Dharmacon Nanog expression in presence of PI3K inhibitor Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00371-A-5 6195 6195 RPS6KA1 0.888266103777 none Dharmacon Nanog expression in presence of retinoic acid Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways Gonzales et al. 2015 26232226 Cell line NANOG-GFP H1 hESC NANOG expression Fluorescence Dharmacon and Ambion Selected genes siRNA Z-score >1,25 OR >1,5 [in at least two replicates] Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted.
GR00376-A-1 6195 6195 RPS6KA1 0.229907932 none Mitigators of SS1P-induced immunotoxicity Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity Pasetto et al. 2015 25713356 Cell line KB cells Viability Luminescence Ambion Silencer Select Version 4 Genome-wide siRNA RSA P-value <0.001 SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID
GR00376-A-2 6195 6195 RPS6KA1 0.033647338 none Sensitizers of SS1P-induced immunotoxicity Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity Pasetto et al. 2015 25713356 Cell line KB cells Viability Luminescence Ambion Silencer Select Version 4 Genome-wide siRNA RSA P-value <0.001 SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID
GR00378-A 6195 RPS6KA1 -0.569433703 none Poliovirus vaccine production Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game van der Sanden et al. 2015 26581994 Cell line HEp-2C Infection with Attenuated Poliovirus ELISA Dharmacon Genome-wide siRNA Z-score > For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol
6195 NM_002953 RPS6KA1 30.374 none
GR00386-A-1 6195 6195 RPS6KA1 65.8669500841395 Decreased viability NOD2 stimulation by MDP A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. Warner et al. 2014 25170077 Cell line HEK293 stably expressing NOD2 Viability Luminescence Dharmacon Genome-wide siRNA Percentage growth Decreased: <70, increased: >120 Reagent IDs not provided
GR00386-A-2 6195 6195 RPS6KA1 -132.9 none MDP-induced IL-8 secretion A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. Warner et al. 2014 25170077 Cell line HEK293 stably expressing NOD2 IL-8 secretion ELISA Dharmacon Genome-wide siRNA Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided