Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 11789
  • Symbol: Apc
  • Description: APC, WNT signaling pathway regulator

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
11789 GO:0000165 IGI acts_upstream_of MAPK cascade 16478791 Process
11789 GO:0000165 IMP acts_upstream_of MAPK cascade 16478791 Process
11789 GO:0000281 IMP acts_upstream_of_or_within mitotic cytokinesis 17570218,17893240 Process
11789 GO:0001822 IMP acts_upstream_of_or_within kidney development 15550389 Process
11789 GO:0001935 IGI acts_upstream_of endothelial cell proliferation 9159163 Process
11789 GO:0001935 IMP acts_upstream_of endothelial cell proliferation 9060821 Process
11789 GO:0001937 IGI acts_upstream_of_or_within negative regulation of endothelial cell proliferation 9159163 Process
11789 GO:0001937 IMP acts_upstream_of_or_within negative regulation of endothelial cell proliferation 9060821 Process
11789 GO:0001942 IMP acts_upstream_of_or_within hair follicle development 17002498 Process
11789 GO:0006915 IMP acts_upstream_of apoptotic process 11756652,16950562 Process
11789 GO:0007019 IMP acts_upstream_of microtubule depolymerization 16525027 Process
11789 GO:0007026 IMP acts_upstream_of_or_within negative regulation of microtubule depolymerization 16525027 Process
11789 GO:0007091 IGI acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle 15767571 Process
11789 GO:0007091 IMP acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle 15767571,16025118 Process
11789 GO:0007155 IMP acts_upstream_of cell adhesion 16368433 Process
11789 GO:0007389 IMP acts_upstream_of_or_within pattern specification process 16740478 Process
11789 GO:0007409 IGI acts_upstream_of_or_within axonogenesis 18716223 Process
11789 GO:0007409 IMP acts_upstream_of_or_within axonogenesis 15207235,18716223 Process
11789 GO:0008283 IGI acts_upstream_of cell population proliferation 8945508,8978062,8978063,9159163,9288104,9506519,9515784,106268..... Process
11789 GO:0008283 IMP acts_upstream_of cell population proliferation 7954428,8945508,9135000,9865728,9927046,10334197,10506110,1053..... Process
11789 GO:0008285 IGI acts_upstream_of_or_within negative regulation of cell population proliferation 8945508,8978062,8978063,9288104,9506519,9515784,10626800,10708..... Process
11789 GO:0008285 IMP acts_upstream_of_or_within negative regulation of cell population proliferation 7954428,8945508,9135000,9865728,9927046,10334197,10506110,1130..... Process
11789 GO:0008286 IMP involved_in insulin receptor signaling pathway 28057765 Process
11789 GO:0009798 IMP acts_upstream_of_or_within axis specification 12645927 Process
11789 GO:0009952 IMP acts_upstream_of_or_within anterior/posterior pattern specification 12645927 Process
11789 GO:0009953 IMP acts_upstream_of_or_within dorsal/ventral pattern formation 12645927 Process
11789 GO:0009954 IMP acts_upstream_of_or_within proximal/distal pattern formation 16887818 Process
11789 GO:0010632 IMP acts_upstream_of_or_within regulation of epithelial cell migration 9371501 Process
11789 GO:0010761 IMP acts_upstream_of fibroblast migration 17192415 Process
11789 GO:0010763 IMP acts_upstream_of_or_within positive regulation of fibroblast migration 17192415 Process
11789 GO:0016055 IDA acts_upstream_of_or_within Wnt signaling pathway 10346819 Process
11789 GO:0016055 IGI acts_upstream_of Wnt signaling pathway 18644872 Process
11789 GO:0016055 IMP acts_upstream_of Wnt signaling pathway 11756652,15198980,15550389,15563600,16740478,16887818,17363566..... Process
11789 GO:0016055 IMP acts_upstream_of_or_within Wnt signaling pathway 12645927 Process
11789 GO:0016477 IMP acts_upstream_of_or_within cell migration 15198980 Process
11789 GO:0019827 IMP acts_upstream_of_or_within stem cell population maintenance 18725524 Process
11789 GO:0030163 IMP acts_upstream_of protein catabolic process 16478791 Process
11789 GO:0030178 IGI acts_upstream_of_or_within negative regulation of Wnt signaling pathway 18644872 Process
11789 GO:0030178 IMP acts_upstream_of_or_within negative regulation of Wnt signaling pathway 11756652,15198980,15550389,15563600,16740478,16887818,17363566..... Process
11789 GO:0030334 IGI acts_upstream_of_or_within regulation of cell migration 17377531 Process
11789 GO:0030856 IMP acts_upstream_of_or_within regulation of epithelial cell differentiation 9771477 Process
11789 GO:0031116 IMP acts_upstream_of_or_within positive regulation of microtubule polymerization 16525027 Process
11789 GO:0031122 IGI acts_upstream_of_or_within cytoplasmic microtubule organization 18716223 Process
11789 GO:0033077 IMP acts_upstream_of_or_within T cell differentiation in thymus 16025118 Process
11789 GO:0035019 IGI acts_upstream_of_or_within somatic stem cell population maintenance 1541640 Process
11789 GO:0035019 IMP acts_upstream_of_or_within somatic stem cell population maintenance 1541640,18725524 Process
11789 GO:0042476 IMP acts_upstream_of odontogenesis 17002498 Process
11789 GO:0042483 IMP acts_upstream_of_or_within negative regulation of odontogenesis 17002498 Process
11789 GO:0043066 IMP acts_upstream_of_or_within negative regulation of apoptotic process 11756652 Process
11789 GO:0043409 IGI acts_upstream_of_or_within negative regulation of MAPK cascade 16478791 Process
11789 GO:0043409 IMP acts_upstream_of_or_within negative regulation of MAPK cascade 16478791 Process
11789 GO:0043588 IMP acts_upstream_of_or_within skin development 9453487 Process
11789 GO:0044336 IGI acts_upstream_of_or_within canonical Wnt signaling pathway involved in negative regulation of apoptotic process 17377531 Process
11789 GO:0044337 IGI acts_upstream_of_or_within canonical Wnt signaling pathway involved in positive regulation of apoptotic process 17377531 Process
11789 GO:0044346 IMP acts_upstream_of fibroblast apoptotic process 17227893 Process
11789 GO:0045595 IGI acts_upstream_of_or_within regulation of cell differentiation 17377531 Process
11789 GO:0045597 IMP acts_upstream_of_or_within positive regulation of cell differentiation 15198980,16709231 Process
11789 GO:0045667 IMP acts_upstream_of_or_within regulation of osteoblast differentiation 15802266 Process
11789 GO:0045670 IMP acts_upstream_of_or_within regulation of osteoclast differentiation 15802266 Process
11789 GO:0045732 IMP acts_upstream_of_or_within positive regulation of protein catabolic process 16478791 Process
11789 GO:0045785 IMP acts_upstream_of_or_within positive regulation of cell adhesion 16368433 Process
11789 GO:0046716 IGI acts_upstream_of_or_within muscle cell cellular homeostasis 18056981 Process
11789 GO:0046785 IMP acts_upstream_of microtubule polymerization 16525027 Process
11789 GO:0048538 IMP acts_upstream_of_or_within thymus development 16025118,17002498 Process
11789 GO:0050673 IGI acts_upstream_of epithelial cell proliferation 14758356 Process
11789 GO:0050673 IMP acts_upstream_of epithelial cell proliferation 10535960,12370429,15550389,15563600 Process
11789 GO:0050680 IGI acts_upstream_of_or_within negative regulation of epithelial cell proliferation 9037065,10451698,14758356 Process
11789 GO:0050680 IMP acts_upstream_of_or_within negative regulation of epithelial cell proliferation 10535960,12370429,15550389,15563600 Process
11789 GO:0051171 IMP acts_upstream_of_or_within regulation of nitrogen compound metabolic process 16740478 Process
11789 GO:0051276 IGI acts_upstream_of_or_within chromosome organization 17200209 Process
11789 GO:0051276 IMP acts_upstream_of_or_within chromosome organization 17200209 Process
11789 GO:0051301 IMP acts_upstream_of cell division 16950562 Process
11789 GO:0051726 IMP acts_upstream_of_or_within regulation of cell cycle 8988060 Process
11789 GO:0051781 IMP acts_upstream_of_or_within positive regulation of cell division 16950562 Process
11789 GO:0051988 IMP acts_upstream_of_or_within regulation of attachment of spindle microtubules to kinetochore 17227893 Process
11789 GO:0060041 IMP acts_upstream_of_or_within retina development in camera-type eye 10982921 Process
11789 GO:0060070 IMP acts_upstream_of canonical Wnt signaling pathway 11756652,15198980,15563600 Process
11789 GO:0060070 IMP acts_upstream_of_or_within canonical Wnt signaling pathway 16887818 Process
11789 GO:0060767 IMP acts_upstream_of epithelial cell proliferation involved in prostate gland development 17363566 Process
11789 GO:0060770 IMP acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development 17363566 Process
11789 GO:0090090 IMP acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway 11756652,15198980,15563600 Process
11789 GO:0120162 IMP involved_in positive regulation of cold-induced thermogenesis 26948948 Process
11789 GO:1904019 IMP acts_upstream_of epithelial cell apoptotic process 16950562 Process
11789 GO:1904036 IMP acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process 16950562 Process
11789 GO:1904698 IGI acts_upstream_of_or_within negative regulation of acinar cell proliferation 17596282 Process
11789 GO:1904698 IMP acts_upstream_of_or_within negative regulation of acinar cell proliferation 17596282 Process
11789 GO:1904781 IMP involved_in positive regulation of protein localization to centrosome 28057765 Process
11789 GO:1990863 IGI acts_upstream_of acinar cell proliferation 17596282 Process
11789 GO:1990863 IMP acts_upstream_of acinar cell proliferation 17596282 Process
11789 GO:2000271 IMP acts_upstream_of_or_within positive regulation of fibroblast apoptotic process 17227893 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
11789 GO:0002020 IPI enables protease binding 18281465 Function
11789 GO:0005515 IPI enables protein binding 15327768,16611247,21689717 Function
11789 GO:0008013 IDA enables beta-catenin binding 10346819 Function
11789 GO:0008013 IPI enables beta-catenin binding 12874278 Function
11789 GO:0019901 IPI enables protein kinase binding 28057765 Function
11789 GO:0051010 IDA enables microtubule plus-end binding 18716223 Function
11789 GO:0070840 IPI enables dynein complex binding 28057765 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
11789 GO:0005634 IDA located_in nucleus 10346819,28057765 Component
11789 GO:0005737 IDA located_in cytoplasm 8670282,28057765 Component
11789 GO:0015630 IDA located_in microtubule cytoskeleton 16525027,16621792 Component
11789 GO:0030424 IDA located_in axon 15207235 Component
11789 GO:0030426 IDA located_in growth cone 15207235 Component
11789 GO:0031253 IDA located_in cell projection membrane 16621792 Component
11789 GO:0034750 IDA part_of Scrib-APC-beta-catenin complex 16611247 Component
11789 GO:0042995 IDA located_in cell projection 16525027 Component
11789 GO:0044295 IDA located_in axonal growth cone 18716223 Component