Gene Ontology

Gene Info

• Species: Mouse (Mus musculus)
• GeneID: 12229
• Symbol: Btk
• Description: Bruton agammaglobulinemia tyrosine kinase

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
12229	GO:0001818	IMP	involved_in	negative regulation of cytokine production	23544144	Process
12229	GO:0002344	IMP	acts_upstream_of_or_within	B cell affinity maturation	7680896	Process
12229	GO:0006468	IDA	acts_upstream_of_or_within	protein phosphorylation	12235209	Process
12229	GO:0007249	IMP	acts_upstream_of_or_within	I-kappaB kinase/NF-kappaB signaling	14597404	Process
12229	GO:0018108	IDA	acts_upstream_of_or_within	peptidyl-tyrosine phosphorylation	10872802	Process
12229	GO:0030889	IMP	acts_upstream_of_or_within	negative regulation of B cell proliferation	7680896	Process
12229	GO:0048469	IMP	acts_upstream_of_or_within	cell maturation	14734712	Process
12229	GO:0098761	IMP	acts_upstream_of_or_within	cellular response to interleukin-7	7680896	Process
12229	GO:1900227	IDA	involved_in	positive regulation of NLRP3 inflammasome complex assembly	34554188	Process

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
12229	GO:0004713	EXP	enables	protein tyrosine kinase activity	7565679,8630736	Function
12229	GO:0004713	IDA	enables	protein tyrosine kinase activity	10872802,11007757,34554188	Function
12229	GO:0005515	IPI	enables	protein binding	11007757,15102471,15196959,15456761,21441935	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
12229	GO:0005634	IDA	located_in	nucleus	11007757	Component
12229	GO:0005737	IDA	located_in	cytoplasm	11007757	Component
12229	GO:0031410	IDA	located_in	cytoplasmic vesicle	14657254	Component