Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 16392
  • Symbol: Isl1
  • Description: ISL1 transcription factor, LIM/homeodomain

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16392 GO:0000122 IMP involved_in negative regulation of transcription by RNA polymerase II 18849985 Process
16392 GO:0001755 IGI acts_upstream_of_or_within neural crest cell migration 16687132 Process
16392 GO:0003007 IGI acts_upstream_of_or_within heart morphogenesis 16687132 Process
16392 GO:0003148 IGI involved_in outflow tract septum morphogenesis 17519333 Process
16392 GO:0003151 IGI involved_in outflow tract morphogenesis 17519333 Process
16392 GO:0003203 IGI involved_in endocardial cushion morphogenesis 17519333 Process
16392 GO:0003215 IGI involved_in cardiac right ventricle morphogenesis 17519333 Process
16392 GO:0003266 IMP acts_upstream_of_or_within regulation of secondary heart field cardioblast proliferation 19620969 Process
16392 GO:0006366 IDA acts_upstream_of transcription by RNA polymerase II 22343712 Process
16392 GO:0007507 IMP acts_upstream_of_or_within heart development 14667410 Process
16392 GO:0008283 IDA acts_upstream_of cell population proliferation 15659653 Process
16392 GO:0008284 IDA acts_upstream_of_or_within positive regulation of cell population proliferation 15659653 Process
16392 GO:0010468 IMP acts_upstream_of_or_within regulation of gene expression 19666821 Process
16392 GO:0010575 IDA involved_in positive regulation of vascular endothelial growth factor production 22727192 Process
16392 GO:0021520 IGI acts_upstream_of_or_within spinal cord motor neuron cell fate specification 19666821 Process
16392 GO:0021522 IMP acts_upstream_of_or_within spinal cord motor neuron differentiation 8565076 Process
16392 GO:0021524 IGI acts_upstream_of_or_within visceral motor neuron differentiation 14766174 Process
16392 GO:0021559 IMP involved_in trigeminal nerve development 18849985 Process
16392 GO:0021983 IMP acts_upstream_of_or_within pituitary gland development 9806931 Process
16392 GO:0030182 IGI acts_upstream_of neuron differentiation 14766174 Process
16392 GO:0030182 IGI acts_upstream_of_or_within neuron differentiation 18434416 Process
16392 GO:0030182 IMP acts_upstream_of_or_within neuron differentiation 8565076,18367596 Process
16392 GO:0031016 IMP acts_upstream_of_or_within pancreas development 9000074 Process
16392 GO:0031290 IMP acts_upstream_of_or_within retinal ganglion cell axon guidance 18434421 Process
16392 GO:0032725 IDA involved_in positive regulation of granulocyte macrophage colony-stimulating factor production 22727192 Process
16392 GO:0032729 IDA involved_in positive regulation of type II interferon production 22727192 Process
16392 GO:0032730 IDA involved_in positive regulation of interleukin-1 alpha production 22727192 Process
16392 GO:0032731 IDA involved_in positive regulation of interleukin-1 beta production 22727192 Process
16392 GO:0032735 IDA involved_in positive regulation of interleukin-12 production 22727192 Process
16392 GO:0032755 IDA involved_in positive regulation of interleukin-6 production 22727192 Process
16392 GO:0032760 IDA involved_in positive regulation of tumor necrosis factor production 22727192 Process
16392 GO:0042531 IDA acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein 15659653 Process
16392 GO:0043388 IDA acts_upstream_of_or_within positive regulation of DNA binding 15659653 Process
16392 GO:0043524 IMP involved_in negative regulation of neuron apoptotic process 18849985 Process
16392 GO:0045597 IMP involved_in positive regulation of cell differentiation 25775587 Process
16392 GO:0045665 IGI acts_upstream_of_or_within negative regulation of neuron differentiation 14766174 Process
16392 GO:0045766 IMP involved_in positive regulation of angiogenesis 22727192 Process
16392 GO:0045944 IDA acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 19620969,22343712 Process
16392 GO:0045944 IGI acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 18434421 Process
16392 GO:0045944 IMP involved_in positive regulation of transcription by RNA polymerase II 14664703,18849985,24643061 Process
16392 GO:0048663 IGI acts_upstream_of_or_within neuron fate commitment 14766174 Process
16392 GO:0048665 IMP involved_in neuron fate specification 18849985 Process
16392 GO:0048762 IMP acts_upstream_of_or_within mesenchymal cell differentiation 9000074 Process
16392 GO:0048863 IMP acts_upstream_of_or_within stem cell differentiation 9000074 Process
16392 GO:0048880 IMP involved_in sensory system development 18849985 Process
16392 GO:0048935 IGI acts_upstream_of_or_within peripheral nervous system neuron development 21734270 Process
16392 GO:0048936 IMP involved_in peripheral nervous system neuron axonogenesis 18849985 Process
16392 GO:0050728 IMP involved_in negative regulation of inflammatory response 22727192 Process
16392 GO:0055010 IGI involved_in ventricular cardiac muscle tissue morphogenesis 17519333 Process
16392 GO:0060037 IGI involved_in pharyngeal system development 17519333 Process
16392 GO:0060070 IGI acts_upstream_of canonical Wnt signaling pathway 19620969 Process
16392 GO:0060379 IMP acts_upstream_of_or_within cardiac muscle cell myoblast differentiation 19620969 Process
16392 GO:0060384 IMP involved_in innervation 18849985 Process
16392 GO:0060413 IGI involved_in atrial septum morphogenesis 17519333 Process
16392 GO:0060913 IMP acts_upstream_of_or_within cardiac cell fate determination 19620969 Process
16392 GO:0060931 IMP involved_in sinoatrial node cell development 26193633 Process
16392 GO:0071657 IDA involved_in positive regulation of granulocyte colony-stimulating factor production 22727192 Process
16392 GO:0086091 IMP acts_upstream_of regulation of heart rate by cardiac conduction 26193633 Process
16392 GO:0090090 IGI acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway 19620969 Process
16392 GO:1901258 IDA involved_in positive regulation of macrophage colony-stimulating factor production 22727192 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16392 GO:0000785 IDA part_of chromatin 18539116 Component
16392 GO:0005634 IDA located_in nucleus 10536059,12900460,14664703,14702043,15659653,17928203,18434421..... Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16392 GO:0000976 IDA enables transcription cis-regulatory region binding 18539116 Function
16392 GO:0001228 IDA enables DNA-binding transcription activator activity, RNA polymerase II-specific 15659653 Function
16392 GO:0003677 IDA enables DNA binding 19620969 Function
16392 GO:0003682 IDA enables chromatin binding 18434421,19620969,21734270 Function
16392 GO:0005515 IPI enables protein binding 9192866,10431247,15659653,18583962,19666821,20211142,22343712,..... Function
16392 GO:0043565 IDA enables sequence-specific DNA binding 24643061 Function
16392 GO:1990841 IDA enables promoter-specific chromatin binding 24643061 Function