Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 18015
  • Symbol: Nf1
  • Description: neurofibromin 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18015 GO:0000165 IMP acts_upstream_of MAPK cascade 16644864 Process
18015 GO:0000165 IMP acts_upstream_of_or_within MAPK cascade 14724565 Process
18015 GO:0001525 IGI acts_upstream_of angiogenesis 16648142 Process
18015 GO:0001649 IMP acts_upstream_of_or_within osteoblast differentiation 16893911 Process
18015 GO:0001656 IMP acts_upstream_of_or_within metanephros development 7926784 Process
18015 GO:0001666 IMP acts_upstream_of_or_within response to hypoxia 16288202 Process
18015 GO:0001889 IMP acts_upstream_of_or_within liver development 7926784 Process
18015 GO:0001935 IGI acts_upstream_of endothelial cell proliferation 16644864 Process
18015 GO:0001935 IMP acts_upstream_of endothelial cell proliferation 16288202 Process
18015 GO:0001937 IMP acts_upstream_of_or_within negative regulation of endothelial cell proliferation 16288202 Process
18015 GO:0001938 IGI acts_upstream_of_or_within positive regulation of endothelial cell proliferation 16644864 Process
18015 GO:0001952 IMP acts_upstream_of_or_within regulation of cell-matrix adhesion 16405917 Process
18015 GO:0001953 IGI acts_upstream_of_or_within negative regulation of cell-matrix adhesion 17053831 Process
18015 GO:0002686 IGI acts_upstream_of_or_within negative regulation of leukocyte migration 17053831 Process
18015 GO:0006469 IGI acts_upstream_of_or_within negative regulation of protein kinase activity 17053831 Process
18015 GO:0006469 IMP acts_upstream_of_or_within negative regulation of protein kinase activity 16835260 Process
18015 GO:0006606 IMP acts_upstream_of protein import into nucleus 12469121 Process
18015 GO:0006915 IMP acts_upstream_of apoptotic process 15944386 Process
18015 GO:0007154 IMP acts_upstream_of_or_within cell communication 10442636 Process
18015 GO:0007265 IGI acts_upstream_of Ras protein signal transduction 15665300,17053831 Process
18015 GO:0007265 IGI acts_upstream_of_or_within Ras protein signal transduction 10845775 Process
18015 GO:0007265 IMP acts_upstream_of Ras protein signal transduction 11246230,15665300,15944386,16835260,16893911 Process
18015 GO:0007265 IMP acts_upstream_of_or_within Ras protein signal transduction 8563750,9001241,10498620,11435472,12469121,16906226..... Process
18015 GO:0007269 IGI acts_upstream_of neurotransmitter secretion 16298082 Process
18015 GO:0007269 IMP acts_upstream_of neurotransmitter secretion 16298082 Process
18015 GO:0007405 IMP acts_upstream_of neuroblast proliferation 7926784,15944386 Process
18015 GO:0007406 IMP acts_upstream_of_or_within negative regulation of neuroblast proliferation 7926784,15944386 Process
18015 GO:0007420 IMP acts_upstream_of_or_within brain development 10419687 Process
18015 GO:0007422 IMP acts_upstream_of_or_within peripheral nervous system development 10419687 Process
18015 GO:0007507 IMP acts_upstream_of_or_within heart development 7920653,7926784,10419687,12469121,16906226 Process
18015 GO:0007519 IMP acts_upstream_of_or_within skeletal muscle tissue development 7926784 Process
18015 GO:0008283 IGI acts_upstream_of cell population proliferation 9001241,10620616,10973261,11401406,11435472,15665300..... Process
18015 GO:0008283 IMP acts_upstream_of cell population proliferation 8563750,9001241,10383727,10442636,10498620,11401406,14982883,1..... Process
18015 GO:0008285 IGI acts_upstream_of_or_within negative regulation of cell population proliferation 10591652,11401406 Process
18015 GO:0008285 IMP acts_upstream_of_or_within negative regulation of cell population proliferation 8563750,10498620,11401406,14982883 Process
18015 GO:0008542 IGI acts_upstream_of_or_within visual learning 9054942,11793011,16271875 Process
18015 GO:0008542 IMP acts_upstream_of_or_within visual learning 11793011 Process
18015 GO:0008625 IGI acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors 15039234 Process
18015 GO:0008625 IMP acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors 15039234 Process
18015 GO:0010468 IGI acts_upstream_of_or_within regulation of gene expression 25242307 Process
18015 GO:0010626 IGI acts_upstream_of_or_within negative regulation of Schwann cell proliferation 9001241 Process
18015 GO:0010626 IMP acts_upstream_of_or_within negative regulation of Schwann cell proliferation 9001241 Process
18015 GO:0014009 IGI acts_upstream_of glial cell proliferation 10973261,11246230,15665300 Process
18015 GO:0014009 IMP acts_upstream_of glial cell proliferation 10442636,11246230 Process
18015 GO:0014010 IGI acts_upstream_of Schwann cell proliferation 9001241 Process
18015 GO:0014010 IMP acts_upstream_of Schwann cell proliferation 9001241 Process
18015 GO:0014044 IMP acts_upstream_of_or_within Schwann cell development 9001241 Process
18015 GO:0014065 IMP acts_upstream_of_or_within phosphatidylinositol 3-kinase signaling 14724565 Process
18015 GO:0016477 IGI acts_upstream_of cell migration 14724565,16644864 Process
18015 GO:0016477 IMP acts_upstream_of cell migration 14724565 Process
18015 GO:0016525 IGI acts_upstream_of_or_within negative regulation of angiogenesis 16648142 Process
18015 GO:0016601 IGI acts_upstream_of Rac protein signal transduction 15665300 Process
18015 GO:0021510 IMP acts_upstream_of_or_within spinal cord development 16906226 Process
18015 GO:0021764 IGI acts_upstream_of_or_within amygdala development 25242307 Process
18015 GO:0021897 IMP acts_upstream_of_or_within forebrain astrocyte development 15944386 Process
18015 GO:0021915 IGI acts_upstream_of_or_within neural tube development 10419687 Process
18015 GO:0021987 IMP acts_upstream_of_or_within cerebral cortex development 11297510 Process
18015 GO:0022011 IMP acts_upstream_of_or_within myelination in peripheral nervous system 10586246 Process
18015 GO:0030036 IGI acts_upstream_of_or_within actin cytoskeleton organization 15665300 Process
18015 GO:0030036 IMP acts_upstream_of_or_within actin cytoskeleton organization 16405917 Process
18015 GO:0030198 IMP acts_upstream_of_or_within extracellular matrix organization 16835260 Process
18015 GO:0030199 IMP acts_upstream_of_or_within collagen fibril organization 10383727 Process
18015 GO:0030316 IGI acts_upstream_of osteoclast differentiation 17053831 Process
18015 GO:0030325 IMP acts_upstream_of_or_within adrenal gland development 16906226 Process
18015 GO:0032228 IGI acts_upstream_of_or_within regulation of synaptic transmission, GABAergic 11793011 Process
18015 GO:0033024 IGI acts_upstream_of mast cell apoptotic process 15039234 Process
18015 GO:0033027 IGI acts_upstream_of_or_within positive regulation of mast cell apoptotic process 15039234 Process
18015 GO:0033028 IMP acts_upstream_of myeloid cell apoptotic process 17053831 Process
18015 GO:0033034 IMP acts_upstream_of_or_within positive regulation of myeloid cell apoptotic process 17053831 Process
18015 GO:0034605 IDA acts_upstream_of_or_within cellular response to heat 20661302 Process
18015 GO:0035021 IGI acts_upstream_of_or_within negative regulation of Rac protein signal transduction 15665300 Process
18015 GO:0036135 IGI acts_upstream_of Schwann cell migration 14724565 Process
18015 GO:0036135 IMP acts_upstream_of Schwann cell migration 14724565 Process
18015 GO:0042060 IMP acts_upstream_of_or_within wound healing 10383727 Process
18015 GO:0042127 IGI acts_upstream_of_or_within regulation of cell population proliferation 10678181 Process
18015 GO:0042308 IMP acts_upstream_of_or_within negative regulation of protein import into nucleus 12469121 Process
18015 GO:0043065 IMP acts_upstream_of_or_within positive regulation of apoptotic process 15944386 Process
18015 GO:0043407 IGI acts_upstream_of_or_within negative regulation of MAP kinase activity 10620616,12409258,16271875 Process
18015 GO:0043407 IMP acts_upstream_of_or_within negative regulation of MAP kinase activity 11297510,12409258,16271875 Process
18015 GO:0043408 IGI acts_upstream_of_or_within regulation of MAPK cascade 25242307 Process
18015 GO:0043409 IMP acts_upstream_of_or_within negative regulation of MAPK cascade 16644864 Process
18015 GO:0043473 IGI acts_upstream_of_or_within pigmentation 10620616 Process
18015 GO:0043473 IMP acts_upstream_of_or_within pigmentation 10594763,10844550 Process
18015 GO:0043525 IGI acts_upstream_of_or_within positive regulation of neuron apoptotic process 10845775 Process
18015 GO:0043525 IMP acts_upstream_of_or_within positive regulation of neuron apoptotic process 7671302,11297510 Process
18015 GO:0043547 IMP acts_upstream_of_or_within positive regulation of GTPase activity 8563750,11435472 Process
18015 GO:0045124 IMP acts_upstream_of_or_within regulation of bone resorption 17053831 Process
18015 GO:0045671 IGI acts_upstream_of_or_within negative regulation of osteoclast differentiation 17053831 Process
18015 GO:0045685 IMP acts_upstream_of_or_within regulation of glial cell differentiation 12904481 Process
18015 GO:0045762 IMP acts_upstream_of_or_within positive regulation of adenylate cyclase activity 11788835 Process
18015 GO:0045765 IMP acts_upstream_of_or_within regulation of angiogenesis 16288202 Process
18015 GO:0046580 IGI acts_upstream_of_or_within negative regulation of Ras protein signal transduction 15665300,17053831 Process
18015 GO:0046580 IMP acts_upstream_of_or_within negative regulation of Ras protein signal transduction 11246230,15665300,15944386,16835260,16893911 Process
18015 GO:0046929 IGI acts_upstream_of_or_within negative regulation of neurotransmitter secretion 16298082 Process
18015 GO:0046929 IMP acts_upstream_of_or_within negative regulation of neurotransmitter secretion 16298082 Process
18015 GO:0048144 IMP acts_upstream_of fibroblast proliferation 10383727 Process
18015 GO:0048147 IMP acts_upstream_of_or_within negative regulation of fibroblast proliferation 10383727 Process
18015 GO:0048147 IMP involved_in negative regulation of fibroblast proliferation 20154697 Process
18015 GO:0048169 IGI acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity 11793011 Process
18015 GO:0048169 IMP acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity 11793011 Process
18015 GO:0048485 IMP acts_upstream_of_or_within sympathetic nervous system development 7926784,16906226 Process
18015 GO:0048593 IMP acts_upstream_of_or_within camera-type eye morphogenesis 7926784 Process
18015 GO:0048708 IMP acts_upstream_of astrocyte differentiation 9878702,10442636,11297510 Process
18015 GO:0048709 IMP acts_upstream_of oligodendrocyte differentiation 15944386 Process
18015 GO:0048712 IMP acts_upstream_of_or_within negative regulation of astrocyte differentiation 9878702,10442636,11297510 Process
18015 GO:0048715 IMP acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation 15944386 Process
18015 GO:0048745 IMP acts_upstream_of_or_within smooth muscle tissue development 7926784 Process
18015 GO:0048820 IMP acts_upstream_of_or_within hair follicle maturation 25340873 Process
18015 GO:0048844 IMP acts_upstream_of_or_within artery morphogenesis 7926784 Process
18015 GO:0048853 IMP acts_upstream_of_or_within forebrain morphogenesis 11297510 Process
18015 GO:0051402 IGI acts_upstream_of neuron apoptotic process 10845775 Process
18015 GO:0051402 IMP acts_upstream_of neuron apoptotic process 7671302,11297510 Process
18015 GO:0060253 IGI acts_upstream_of_or_within negative regulation of glial cell proliferation 10973261,11246230,15665300 Process
18015 GO:0060253 IMP acts_upstream_of_or_within negative regulation of glial cell proliferation 10442636,11246230 Process
18015 GO:0060291 IGI acts_upstream_of_or_within long-term synaptic potentiation 16271875 Process
18015 GO:0060291 IMP acts_upstream_of_or_within long-term synaptic potentiation 16271875 Process
18015 GO:0061534 IGI acts_upstream_of_or_within gamma-aminobutyric acid secretion, neurotransmission 25242307 Process
18015 GO:0061535 IGI acts_upstream_of_or_within glutamate secretion, neurotransmission 25242307 Process
18015 GO:0070372 IGI acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade 16271875 Process
18015 GO:0070372 IMP acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade 16271875 Process
18015 GO:0070662 IGI acts_upstream_of mast cell proliferation 10620616,11435472 Process
18015 GO:0070667 IGI acts_upstream_of_or_within negative regulation of mast cell proliferation 10620616,11435472 Process
18015 GO:0071887 IMP acts_upstream_of leukocyte apoptotic process 17053831 Process
18015 GO:0072089 IGI acts_upstream_of stem cell proliferation 10591653 Process
18015 GO:0097192 IMP acts_upstream_of extrinsic apoptotic signaling pathway in absence of ligand 15039234 Process
18015 GO:0097529 IGI acts_upstream_of myeloid leukocyte migration 17053831 Process
18015 GO:0098597 IGI acts_upstream_of_or_within observational learning 25242307 Process
18015 GO:0099175 IDA involved_in regulation of postsynapse organization 22105171 Process
18015 GO:0099175 IMP involved_in regulation of postsynapse organization 22105171 Process
18015 GO:1900148 IGI acts_upstream_of_or_within negative regulation of Schwann cell migration 14724565 Process
18015 GO:1900148 IMP acts_upstream_of_or_within negative regulation of Schwann cell migration 14724565 Process
18015 GO:1900271 IGI acts_upstream_of_or_within regulation of long-term synaptic potentiation 25242307 Process
18015 GO:1904707 IGI acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell proliferation 16644864 Process
18015 GO:1904738 IGI acts_upstream_of vascular associated smooth muscle cell migration 16644864 Process
18015 GO:1904753 IGI acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration 16644864 Process
18015 GO:1990874 IGI acts_upstream_of vascular associated smooth muscle cell proliferation 16644864 Process
18015 GO:2000108 IMP acts_upstream_of_or_within positive regulation of leukocyte apoptotic process 17053831 Process
18015 GO:2000647 IGI acts_upstream_of_or_within negative regulation of stem cell proliferation 10591653 Process
18015 GO:2001241 IMP acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 15039234 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18015 GO:0005096 IGI enables GTPase activator activity 15665300,16271875 Function
18015 GO:0005096 IMP enables GTPase activator activity 8563750,11435472,16271875,17053831 Function
18015 GO:0005515 IPI enables protein binding 16405917 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18015 GO:0005737 IDA located_in cytoplasm 15133494 Component
18015 GO:0098978 IDA is_active_in glutamatergic synapse 22105171 Component
18015 GO:0098978 IMP is_active_in glutamatergic synapse 22105171 Component