Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 207
  • Symbol: AKT1
  • Description: AKT serine/threonine kinase 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
207 GO:0001934 IDA involved_in positive regulation of protein phosphorylation 19057511 Process
207 GO:0001938 IMP involved_in positive regulation of endothelial cell proliferation 19850054 Process
207 GO:0002042 IMP involved_in cell migration involved in sprouting angiogenesis 28341552 Process
207 GO:0003376 IMP involved_in sphingosine-1-phosphate receptor signaling pathway 18558630 Process
207 GO:0005979 IMP involved_in regulation of glycogen biosynthetic process 8940145 Process
207 GO:0006468 IDA acts_upstream_of_or_within protein phosphorylation 14749367 Process
207 GO:0006468 IDA involved_in protein phosphorylation 11994271,23431171 Process
207 GO:0006469 IMP involved_in negative regulation of protein kinase activity 9373175 Process
207 GO:0006606 IMP involved_in protein import into nucleus 16280327 Process
207 GO:0006924 IMP acts_upstream_of_or_within activation-induced cell death of T cells 14749367 Process
207 GO:0007173 IDA involved_in epidermal growth factor receptor signaling pathway 20878056 Process
207 GO:0007249 IMP involved_in I-kappaB kinase/NF-kappaB signaling 26514923 Process
207 GO:0008284 IMP involved_in positive regulation of cell population proliferation 10983986 Process
207 GO:0008286 IMP involved_in insulin receptor signaling pathway 8978681 Process
207 GO:0010507 IMP involved_in negative regulation of autophagy 18387192 Process
207 GO:0010595 IMP involved_in positive regulation of endothelial cell migration 18558630 Process
207 GO:0010628 IMP involved_in positive regulation of gene expression 28341552 Process
207 GO:0010748 IMP involved_in negative regulation of long-chain fatty acid import across plasma membrane 16814735 Process
207 GO:0010907 IMP involved_in positive regulation of glucose metabolic process 16814735 Process
207 GO:0010918 IMP involved_in positive regulation of mitochondrial membrane potential 10983986 Process
207 GO:0010951 IMP involved_in negative regulation of endopeptidase activity 18387192 Process
207 GO:0014065 IMP involved_in phosphatidylinositol 3-kinase signaling 26514923 Process
207 GO:0016310 IDA involved_in phosphorylation 20333297 Process
207 GO:0018105 IDA involved_in peptidyl-serine phosphorylation 16139227,32322062 Process
207 GO:0018107 IDA involved_in peptidyl-threonine phosphorylation 20605787 Process
207 GO:0019049 IDA involved_in mitigation of host antiviral defense response 14749367 Process
207 GO:0030307 IDA involved_in positive regulation of cell growth 19203586 Process
207 GO:0030334 IMP involved_in regulation of cell migration 19934221 Process
207 GO:0031397 IMP involved_in negative regulation of protein ubiquitination 18292230 Process
207 GO:0031999 IMP involved_in negative regulation of fatty acid beta-oxidation 16814735 Process
207 GO:0032079 IDA involved_in positive regulation of endodeoxyribonuclease activity 20605787 Process
207 GO:0032091 IMP involved_in negative regulation of protein binding 18292230 Process
207 GO:0032436 IDA involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process 23512198 Process
207 GO:0032869 IMP involved_in cellular response to insulin stimulus 16814735 Process
207 GO:0033138 IDA involved_in positive regulation of peptidyl-serine phosphorylation 19667065 Process
207 GO:0034405 IMP involved_in response to fluid shear stress 10376603 Process
207 GO:0034614 IMP involved_in cellular response to reactive oxygen species 26514923 Process
207 GO:0035556 IDA acts_upstream_of_or_within intracellular signal transduction 14749367 Process
207 GO:0035655 IDA involved_in interleukin-18-mediated signaling pathway 21321938 Process
207 GO:0038061 IMP involved_in NIK/NF-kappaB signaling 26514923 Process
207 GO:0043066 IDA involved_in negative regulation of apoptotic process 19203586 Process
207 GO:0043066 IMP involved_in negative regulation of apoptotic process 10983986 Process
207 GO:0043491 IMP involved_in protein kinase B signaling 28341552 Process
207 GO:0043536 IDA involved_in positive regulation of blood vessel endothelial cell migration 20011604 Process
207 GO:0045429 IMP involved_in positive regulation of nitric oxide biosynthetic process 10376603 Process
207 GO:0045600 IMP involved_in positive regulation of fat cell differentiation 8940145 Process
207 GO:0045725 IMP involved_in positive regulation of glycogen biosynthetic process 16814735 Process
207 GO:0045737 IMP involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity 18483258 Process
207 GO:0045824 IDA involved_in negative regulation of innate immune response 26440888 Process
207 GO:0045861 IMP involved_in negative regulation of proteolysis 18387192 Process
207 GO:0045893 IMP involved_in positive regulation of DNA-templated transcription 26514923 Process
207 GO:0046326 IMP involved_in positive regulation of glucose import 8940145,16814735 Process
207 GO:0046889 IDA involved_in positive regulation of lipid biosynthetic process 32322062 Process
207 GO:0046889 IMP involved_in positive regulation of lipid biosynthetic process 8940145 Process
207 GO:0048009 IMP involved_in insulin-like growth factor receptor signaling pathway 8978681 Process
207 GO:0048661 IDA involved_in positive regulation of smooth muscle cell proliferation 21321938 Process
207 GO:0051000 IMP involved_in positive regulation of nitric-oxide synthase activity 10376603 Process
207 GO:0051091 IDA involved_in positive regulation of DNA-binding transcription factor activity 19057511 Process
207 GO:0070141 IDA involved_in response to UV-A 18483258 Process
207 GO:0070848 IDA involved_in response to growth factor 33505021 Process
207 GO:0071276 IMP involved_in cellular response to cadmium ion 26514923 Process
207 GO:0071356 IMP involved_in cellular response to tumor necrosis factor 10983986 Process
207 GO:0072655 IMP involved_in establishment of protein localization to mitochondrion 23962723 Process
207 GO:0072656 IMP involved_in maintenance of protein location in mitochondrion 23962723 Process
207 GO:0110002 IDA involved_in regulation of tRNA methylation 15861136 Process
207 GO:0140052 IMP involved_in cellular response to oxidised low-density lipoprotein particle stimulus 28341552 Process
207 GO:1900087 IMP involved_in positive regulation of G1/S transition of mitotic cell cycle 18483258 Process
207 GO:1900182 IMP involved_in positive regulation of protein localization to nucleus 20605787 Process
207 GO:1903038 IMP involved_in negative regulation of leukocyte cell-cell adhesion 28341552 Process
207 GO:1903078 IMP involved_in positive regulation of protein localization to plasma membrane 8940145 Process
207 GO:1903721 IMP involved_in positive regulation of I-kappaB phosphorylation 26514923 Process
207 GO:1904263 IDA involved_in positive regulation of TORC1 signaling 33594058 Process
207 GO:1905552 IDA involved_in positive regulation of protein localization to endoplasmic reticulum 32322062 Process
207 GO:1990090 IMP involved_in cellular response to nerve growth factor stimulus 20605787 Process
207 GO:2000402 IMP involved_in negative regulation of lymphocyte migration 28341552 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
207 GO:0004674 EXP enables protein serine/threonine kinase activity 17030608 Function
207 GO:0004674 IDA enables protein serine/threonine kinase activity 10102273,10983986,11994271,14749367,15861136,16139227,16540465..... Function
207 GO:0004712 IDA enables protein serine/threonine/tyrosine kinase activity 22797923 Function
207 GO:0005515 IPI enables protein binding 10102273,10983986,11154276,11438723,11839802,12176997,12244133..... Function
207 GO:0005516 IDA enables calmodulin binding 29104511 Function
207 GO:0005524 IDA enables ATP binding 16540465 Function
207 GO:0005547 IDA enables phosphatidylinositol-3,4,5-trisphosphate binding 19203586 Function
207 GO:0016301 IDA enables kinase activity 14749367 Function
207 GO:0030235 IMP enables nitric-oxide synthase regulator activity 10376603 Function
207 GO:0042802 IPI enables identical protein binding 7891724,17554339 Function
207 GO:0042803 IDA enables protein homodimerization activity 10983986 Function
207 GO:0043325 IDA enables phosphatidylinositol-3,4-bisphosphate binding 19203586 Function
207 GO:0071889 IPI enables 14-3-3 protein binding 10102273 Function
207 GO:0099104 IDA enables potassium channel activator activity 33505021 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
207 GO:0005634 IDA located_in nucleus 20333297 Component
207 GO:0005654 IDA located_in nucleoplasm Component
207 GO:0005737 IDA is_active_in cytoplasm 26440888 Component
207 GO:0005737 IDA located_in cytoplasm 19203586,25190803 Component
207 GO:0005829 IDA located_in cytosol 21045808 Component
207 GO:0005886 IDA located_in plasma membrane 14749367,19203586,20333297 Component
207 GO:0015630 IDA located_in microtubule cytoskeleton Component
207 GO:0031982 IDA located_in vesicle 16792529 Component
207 GO:0032991 IDA part_of protein-containing complex 10983986,20878056 Component