Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 25
  • Symbol: ABL1
  • Description: ABL proto-oncogene 1, non-receptor tyrosine kinase

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
25 GO:0000287 IDA enables magnesium ion binding 9144171 Function
25 GO:0000400 IDA enables four-way junction DNA binding 9558345 Function
25 GO:0000405 IDA enables bubble DNA binding 9558345 Function
25 GO:0001784 IPI enables phosphotyrosine residue binding 20624904 Function
25 GO:0004672 IDA enables protein kinase activity 11120811 Function
25 GO:0004672 IMP enables protein kinase activity 24863063 Function
25 GO:0004713 EXP enables protein tyrosine kinase activity 15657136 Function
25 GO:0004713 IDA enables protein tyrosine kinase activity 7590236,9144171,11121037,12944467,15657060,17888034,20823226..... Function
25 GO:0004713 IMP enables protein tyrosine kinase activity 22810897,24520051 Function
25 GO:0004715 IDA enables non-membrane spanning protein tyrosine kinase activity 9461559,10518561 Function
25 GO:0004715 IMP enables non-membrane spanning protein tyrosine kinase activity 28428613 Function
25 GO:0005080 IPI enables protein kinase C binding 10713049 Function
25 GO:0005515 IPI enables protein binding 7590236,9144171,9168117,9346925,9461559,9593709,11374898,11375..... Function
25 GO:0005524 IDA enables ATP binding 9144171 Function
25 GO:0016301 IMP enables kinase activity 28288113 Function
25 GO:0017124 IPI enables SH3 domain binding 7590236 Function
25 GO:0019905 IPI enables syntaxin binding 23006999 Function
25 GO:0030145 IDA enables manganese ion binding 9144171 Function
25 GO:0038191 IPI enables neuropilin binding 24863063 Function
25 GO:0042169 IPI enables SH2 domain binding 12384576 Function
25 GO:0043621 IPI enables protein self-association 10518561 Function
25 GO:0051019 IPI enables mitogen-activated protein kinase binding 11121037 Function
25 GO:0070064 IDA enables proline-rich region binding 15657060 Function
25 GO:0070064 IPI enables proline-rich region binding 7590236 Function
25 GO:0097100 IDA NOT enables supercoiled DNA binding 9558345 Function
25 GO:1990837 IDA enables sequence-specific double-stranded DNA binding 9558345 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
25 GO:0001934 IMP involved_in positive regulation of protein phosphorylation 24700464 Process
25 GO:0006468 IMP involved_in protein phosphorylation 24863063 Process
25 GO:0006974 IDA involved_in DNA damage response 15657060 Process
25 GO:0006979 IGI acts_upstream_of_or_within response to oxidative stress 17626041 Process
25 GO:0007204 IMP acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration 24367707 Process
25 GO:0007229 IMP involved_in integrin-mediated signaling pathway 24863063 Process
25 GO:0010595 IMP involved_in positive regulation of endothelial cell migration 24863063 Process
25 GO:0018108 IDA involved_in peptidyl-tyrosine phosphorylation 7590236,9144171,10713049,11121037 Process
25 GO:0018108 IMP involved_in peptidyl-tyrosine phosphorylation 24520051,28428613 Process
25 GO:0030516 IMP involved_in regulation of axon extension 24520051 Process
25 GO:0031113 IMP involved_in regulation of microtubule polymerization 24520051 Process
25 GO:0032489 IMP involved_in regulation of Cdc42 protein signal transduction 26051942 Process
25 GO:0032956 IMP involved_in regulation of actin cytoskeleton organization 24520051,24863063 Process
25 GO:0035791 IMP involved_in platelet-derived growth factor receptor-beta signaling pathway 24520051 Process
25 GO:0038083 IMP involved_in peptidyl-tyrosine autophosphorylation 24520051 Process
25 GO:0038189 IMP involved_in neuropilin signaling pathway 24863063 Process
25 GO:0042770 IDA involved_in signal transduction in response to DNA damage 9037071,15657060,18280240 Process
25 GO:0043065 IDA involved_in positive regulation of apoptotic process 9037071 Process
25 GO:0043542 IMP involved_in endothelial cell migration 24863063 Process
25 GO:0046777 IDA involved_in protein autophosphorylation 10713049 Process
25 GO:0050731 IDA involved_in positive regulation of peptidyl-tyrosine phosphorylation 15657060 Process
25 GO:0051353 IDA involved_in positive regulation of oxidoreductase activity 12893824 Process
25 GO:0051444 IDA acts_upstream_of_or_within negative regulation of ubiquitin-protein transferase activity 20823226 Process
25 GO:0051496 IMP involved_in positive regulation of stress fiber assembly 24863063 Process
25 GO:0051894 IMP involved_in positive regulation of focal adhesion assembly 24863063 Process
25 GO:0070301 IDA involved_in cellular response to hydrogen peroxide 10713049 Process
25 GO:0071103 IDA involved_in DNA conformation change 9558345 Process
25 GO:0071901 IDA involved_in negative regulation of protein serine/threonine kinase activity 11121037 Process
25 GO:1900026 IMP involved_in positive regulation of substrate adhesion-dependent cell spreading 24863063 Process
25 GO:1900275 IMP acts_upstream_of_or_within negative regulation of phospholipase C activity 24367707 Process
25 GO:1904518 IMP involved_in protein localization to cytoplasmic microtubule plus-end 24520051 Process
25 GO:1904528 IMP involved_in positive regulation of microtubule binding 24520051 Process
25 GO:1904531 IMP involved_in positive regulation of actin filament binding 24520051 Process
25 GO:1990051 IDA involved_in activation of protein kinase C activity 10713049 Process
25 GO:2000042 IDA involved_in negative regulation of double-strand break repair via homologous recombination 9461559 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
25 GO:0005634 IDA located_in nucleus 9168116,17626041,17888034 Component
25 GO:0005654 IDA located_in nucleoplasm Component
25 GO:0005730 IDA located_in nucleolus 12944467,17626041 Component
25 GO:0005737 IDA located_in cytoplasm 17515907 Component
25 GO:0005829 IDA located_in cytosol 11120811 Component
25 GO:0016604 IDA located_in nuclear body Component
25 GO:0032991 IPI part_of protein-containing complex 12384576 Component
25 GO:0048471 IDA located_in perinuclear region of cytoplasm 17888034 Component