Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 27429
  • Symbol: HTRA2
  • Description: HtrA serine peptidase 2

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
27429 GO:0000785 IDA part_of chromatin 24798695 Component
27429 GO:0005634 IDA located_in nucleus 10971580,24798695 Component
27429 GO:0005739 IDA located_in mitochondrion 11583623,11602612 Component
27429 GO:0005739 IMP located_in mitochondrion 11604410 Component
27429 GO:0005758 IDA located_in mitochondrial intermembrane space 15044455 Component
27429 GO:0005829 IDA located_in cytosol 11583623,11602612,11604410,24798695 Component
27429 GO:0005856 IDA located_in cytoskeleton 24798695 Component
27429 GO:0016020 IDA located_in membrane 24798695 Component
27429 GO:1905370 IMP part_of serine-type endopeptidase complex 11967569 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
27429 GO:0004252 IMP enables serine-type endopeptidase activity 10971580,11967569 Function
27429 GO:0005515 IPI enables protein binding 10971580,11583623,11602612,11604410,11801603,15200957,17297443..... Function
27429 GO:0008233 IDA enables peptidase activity 11604410,17266347,20125124,25118933 Function
27429 GO:0008233 IMP enables peptidase activity 24709290 Function
27429 GO:0008236 IDA enables serine-type peptidase activity 11583623 Function
27429 GO:0042802 IPI enables identical protein binding 11967569 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
27429 GO:0006508 IDA involved_in proteolysis 25118933 Process
27429 GO:0006508 IMP involved_in proteolysis 10971580,11967569,24709290 Process
27429 GO:0008630 IMP involved_in intrinsic apoptotic signaling pathway in response to DNA damage 11602612 Process
27429 GO:0010822 IMP involved_in positive regulation of mitochondrion organization 25118933 Process
27429 GO:0012501 IDA involved_in programmed cell death 11583623 Process
27429 GO:0030163 IDA involved_in protein catabolic process 17297443 Process
27429 GO:0034599 IMP involved_in cellular response to oxidative stress 24709290 Process
27429 GO:0034605 IDA involved_in cellular response to heat 10971580 Process
27429 GO:0035458 IDA involved_in cellular response to interferon-beta 17297443 Process
27429 GO:0043065 IMP involved_in positive regulation of apoptotic process 11967569,20125124 Process
27429 GO:0043280 IDA involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 11583623,11604410,17297443 Process
27429 GO:0043280 IMP involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 11967569 Process
27429 GO:0071300 IDA involved_in cellular response to retinoic acid 17297443 Process
27429 GO:0071363 IMP involved_in cellular response to growth factor stimulus 20125124 Process
27429 GO:1903955 HMP involved_in positive regulation of protein targeting to mitochondrion 24270810 Process
27429 GO:2001241 IMP involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 20125124 Process
27429 GO:2001269 IMP involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 11602612 Process