Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 3791
  • Symbol: KDR
  • Description: kinase insert domain receptor

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3791 GO:0001569 IMP acts_upstream_of_or_within branching involved in blood vessel morphogenesis 23688497 Process
3791 GO:0001934 IDA involved_in positive regulation of protein phosphorylation 19033661 Process
3791 GO:0001938 IMP involved_in positive regulation of endothelial cell proliferation 10022831,11387210 Process
3791 GO:0008284 IDA involved_in positive regulation of cell population proliferation 7929439 Process
3791 GO:0008284 IMP involved_in positive regulation of cell population proliferation 15215251 Process
3791 GO:0008360 IDA involved_in regulation of cell shape 7929439 Process
3791 GO:0010595 IMP involved_in positive regulation of endothelial cell migration 10022831 Process
3791 GO:0010629 IDA involved_in negative regulation of gene expression 26879375 Process
3791 GO:0014068 IDA involved_in positive regulation of phosphatidylinositol 3-kinase signaling 9804796 Process
3791 GO:0016239 IGI acts_upstream_of_or_within positive regulation of macroautophagy 23798385 Process
3791 GO:0018108 IDA involved_in peptidyl-tyrosine phosphorylation 10037737,10102632 Process
3791 GO:0030335 IDA involved_in positive regulation of cell migration 7929439 Process
3791 GO:0030335 IMP involved_in positive regulation of cell migration 15215251 Process
3791 GO:0035584 IMP involved_in calcium-mediated signaling using intracellular calcium source 15215251 Process
3791 GO:0035924 IDA involved_in cellular response to vascular endothelial growth factor stimulus 10102632,11387210,19033661,23529610 Process
3791 GO:0035924 IMP involved_in cellular response to vascular endothelial growth factor stimulus 15215251 Process
3791 GO:0036324 IMP involved_in vascular endothelial growth factor receptor-2 signaling pathway 24205206 Process
3791 GO:0038033 IDA involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway 21885851 Process
3791 GO:0038084 IMP involved_in vascular endothelial growth factor signaling pathway 23688497 Process
3791 GO:0043066 IMP involved_in negative regulation of apoptotic process 15215251 Process
3791 GO:0043410 IDA involved_in positive regulation of MAPK cascade 11387210 Process
3791 GO:0043491 IMP involved_in protein kinase B signaling 24863063 Process
3791 GO:0043536 IMP involved_in positive regulation of blood vessel endothelial cell migration 22499991,23688497,26879375 Process
3791 GO:0045766 IMP involved_in positive regulation of angiogenesis 15215251,26879375,28637396 Process
3791 GO:0046777 IDA involved_in protein autophosphorylation 10037737,10102632,19033661 Process
3791 GO:0048010 IDA involved_in vascular endothelial growth factor receptor signaling pathway 10102632,11387210,15215251 Process
3791 GO:0048010 IMP involved_in vascular endothelial growth factor receptor signaling pathway 23529610 Process
3791 GO:0050927 IDA involved_in positive regulation of positive chemotaxis 7929439 Process
3791 GO:0051770 IDA involved_in positive regulation of nitric-oxide synthase biosynthetic process 10600473 Process
3791 GO:0051770 IMP involved_in positive regulation of nitric-oxide synthase biosynthetic process 9837777 Process
3791 GO:0051894 IDA involved_in positive regulation of focal adhesion assembly 12820653 Process
3791 GO:0051901 IGI acts_upstream_of_or_within positive regulation of mitochondrial depolarization 23798385 Process
3791 GO:0061042 IMP involved_in vascular wound healing 22499991,23688497 Process
3791 GO:0070371 IMP involved_in ERK1 and ERK2 cascade 24863063 Process
3791 GO:0070374 IMP involved_in positive regulation of ERK1 and ERK2 cascade 15215251 Process
3791 GO:0090050 IMP involved_in positive regulation of cell migration involved in sprouting angiogenesis 18977327,24205206 Process
3791 GO:0090141 IGI acts_upstream_of_or_within positive regulation of mitochondrial fission 23798385 Process
3791 GO:1904881 IDA involved_in cellular response to hydrogen sulfide 26879375 Process
3791 GO:2000352 IDA involved_in negative regulation of endothelial cell apoptotic process 9804796 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3791 GO:0004713 EXP enables protein tyrosine kinase activity 7999104,9398617,10037737,15962004 Function
3791 GO:0004713 IDA enables protein tyrosine kinase activity 10037737 Function
3791 GO:0005021 IDA enables vascular endothelial growth factor receptor activity 1417831,10022831,10102632,11387210,15215251 Function
3791 GO:0005178 IPI enables integrin binding 10022831,30873824 Function
3791 GO:0005515 IPI enables protein binding 1417831,12509223,15985432,16530705,16763549,16966330,17222790,..... Function
3791 GO:0019838 IPI enables growth factor binding 1417831,10022831 Function
3791 GO:0038085 IPI enables vascular endothelial growth factor binding 25825981 Function
3791 GO:0042802 IPI enables identical protein binding 17293873,20080685,20660291 Function
3791 GO:0045296 IPI enables cadherin binding 11950700,25893857 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3791 GO:0005768 IDA located_in endosome 23262137 Component
3791 GO:0005783 IDA located_in endoplasmic reticulum 23529610 Component
3791 GO:0005794 IDA located_in Golgi apparatus 23262137 Component
3791 GO:0005886 IDA located_in plasma membrane 10102632,23262137,25825981 Component
3791 GO:0045121 IDA located_in membrane raft 23262137 Component