Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 55294
  • Symbol: FBXW7
  • Description: F-box and WD repeat domain containing 7

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
55294 GO:0005515 IPI enables protein binding 15070733,15103331,17157259,17314511,17909182,19412162,20596027..... Function
55294 GO:0030332 IDA enables cyclin binding 12628165 Function
55294 GO:0030332 IPI enables cyclin binding 17434132 Function
55294 GO:0030674 IDA enables protein-macromolecule adaptor activity 12628165 Function
55294 GO:0031625 IPI enables ubiquitin protein ligase binding 12628165 Function
55294 GO:0042802 IPI enables identical protein binding 21620836,23791182 Function
55294 GO:0050816 IDA enables phosphothreonine residue binding 17434132 Function
55294 GO:0097027 IDA enables ubiquitin-protein transferase activator activity 12628165 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
55294 GO:0005737 IDA located_in cytoplasm 23858059 Component
55294 GO:0019005 IDA part_of SCF ubiquitin ligase complex 12628165,15103331,17434132 Component
55294 GO:1990452 IPI part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex 12628165 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
55294 GO:0007062 IMP involved_in sister chromatid cohesion 15917200 Process
55294 GO:0010629 IGI involved_in negative regulation of gene expression 23823476 Process
55294 GO:0010629 IMP involved_in negative regulation of gene expression 23823476 Process
55294 GO:0016567 IDA acts_upstream_of_or_within protein ubiquitination 12354302 Process
55294 GO:0016567 IDA involved_in protein ubiquitination 15103331 Process
55294 GO:0031146 IDA involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 15103331,17434132 Process
55294 GO:0031398 IDA involved_in positive regulation of protein ubiquitination 12628165 Process
55294 GO:0042752 IMP involved_in regulation of circadian rhythm 27238018 Process
55294 GO:0043161 IMP involved_in proteasome-mediated ubiquitin-dependent protein catabolic process 35395208 Process
55294 GO:0045741 IDA involved_in positive regulation of epidermal growth factor-activated receptor activity 20208556 Process
55294 GO:0050821 IDA involved_in protein stabilization 20208556 Process
55294 GO:0051443 IDA involved_in positive regulation of ubiquitin-protein transferase activity 12628165 Process
55294 GO:0070374 IMP involved_in positive regulation of ERK1 and ERK2 cascade 20208556 Process
55294 GO:1901800 IDA involved_in positive regulation of proteasomal protein catabolic process 23858059 Process
55294 GO:1903146 IMP involved_in regulation of autophagy of mitochondrion 24912190 Process
55294 GO:1903378 IDA involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 23858059 Process
55294 GO:1903955 IMP involved_in positive regulation of protein targeting to mitochondrion 24912190 Process
55294 GO:2000060 IDA involved_in positive regulation of ubiquitin-dependent protein catabolic process 20208556 Process
55294 GO:2000060 IMP involved_in positive regulation of ubiquitin-dependent protein catabolic process 27238018 Process
55294 GO:2001205 IMP involved_in negative regulation of osteoclast development 29149593 Process