Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 6714
  • Symbol: SRC
  • Description: SRC proto-oncogene, non-receptor tyrosine kinase

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6714 GO:0004672 IDA enables protein kinase activity 18616680 Function
6714 GO:0004713 EXP enables protein tyrosine kinase activity 1381360,9799234,10861086,11448999,12923167,15735019,16921024,1..... Function
6714 GO:0004713 IDA enables protein tyrosine kinase activity 16441665,19059439,19307596 Function
6714 GO:0004713 IMP enables protein tyrosine kinase activity 20624904,25425738 Function
6714 GO:0004715 IDA enables non-membrane spanning protein tyrosine kinase activity 11606584 Function
6714 GO:0005102 IPI enables signaling receptor binding 19332538 Function
6714 GO:0005178 IPI enables integrin binding 19141530 Function
6714 GO:0005515 IPI enables protein binding 7478590,7537265,8070403,8681387,8849729,9148935,9162084,960009..... Function
6714 GO:0016004 IDA enables phospholipase activator activity 11606584 Function
6714 GO:0019899 IPI enables enzyme binding 21724833 Function
6714 GO:0020037 IDA enables heme binding 21036157 Function
6714 GO:0042169 IPI enables SH2 domain binding 8070403 Function
6714 GO:0043274 IPI enables phospholipase binding 11606584 Function
6714 GO:0044325 IPI enables transmembrane transporter binding 8953041,12538589 Function
6714 GO:0045296 HDA enables cadherin binding 25468996 Function
6714 GO:0046875 IPI enables ephrin receptor binding 12925710 Function
6714 GO:0051219 IPI enables phosphoprotein binding 16441665 Function
6714 GO:0070700 IPI enables BMP receptor binding 26598555 Function
6714 GO:0097110 IPI enables scaffold protein binding 25006397 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6714 GO:0005654 IDA located_in nucleoplasm Component
6714 GO:0005737 IDA located_in cytoplasm 16441665 Component
6714 GO:0005739 IDA located_in mitochondrion 19767770 Component
6714 GO:0005743 IDA located_in mitochondrial inner membrane 12615910 Component
6714 GO:0005764 IDA located_in lysosome 20605918 Component
6714 GO:0005770 IDA located_in late endosome 20605918 Component
6714 GO:0005829 IDA located_in cytosol 19767770 Component
6714 GO:0005886 IDA located_in plasma membrane 20605918 Component
6714 GO:0005901 IDA located_in caveola 17848177 Component
6714 GO:0030054 IDA located_in cell junction Component
6714 GO:0048471 IDA located_in perinuclear region of cytoplasm 19307596 Component
6714 GO:0070062 HDA located_in extracellular exosome 19056867,20458337 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6714 GO:0007179 IMP involved_in transforming growth factor beta receptor signaling pathway 24036928 Process
6714 GO:0007229 IMP involved_in integrin-mediated signaling pathway 24036928 Process
6714 GO:0010632 IMP involved_in regulation of epithelial cell migration 21724833 Process
6714 GO:0010634 IMP involved_in positive regulation of epithelial cell migration 18054784 Process
6714 GO:0018108 IDA acts_upstream_of_or_within peptidyl-tyrosine phosphorylation 22732588 Process
6714 GO:0018108 IDA involved_in peptidyl-tyrosine phosphorylation 12051764 Process
6714 GO:0018108 IMP involved_in peptidyl-tyrosine phosphorylation 11606584,20624904,25425738 Process
6714 GO:0022407 IMP involved_in regulation of cell-cell adhesion 21724833 Process
6714 GO:0031333 IMP involved_in negative regulation of protein-containing complex assembly 19767770 Process
6714 GO:0032211 IMP involved_in negative regulation of telomere maintenance via telomerase 21531765 Process
6714 GO:0035306 IDA involved_in positive regulation of dephosphorylation 23159740 Process
6714 GO:0035332 IMP involved_in positive regulation of hippo signaling 33162394 Process
6714 GO:0035556 IDA involved_in intracellular signal transduction 11606584,15248232 Process
6714 GO:0043066 IMP involved_in negative regulation of apoptotic process 19767770 Process
6714 GO:0043149 IMP involved_in stress fiber assembly 24036928 Process
6714 GO:0043154 IMP involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 19767770 Process
6714 GO:0045747 IDA involved_in positive regulation of Notch signaling pathway 25731159 Process
6714 GO:0046777 IDA involved_in protein autophosphorylation 16441665 Process
6714 GO:0048041 IMP involved_in focal adhesion assembly 21411625 Process
6714 GO:0050731 IMP involved_in positive regulation of peptidyl-tyrosine phosphorylation 26598555,26706435 Process
6714 GO:0051057 IMP involved_in positive regulation of small GTPase mediated signal transduction 18541665 Process
6714 GO:0051897 IMP involved_in positive regulation of protein kinase B signaling 19767770 Process
6714 GO:0051902 IMP involved_in negative regulation of mitochondrial depolarization 19767770 Process
6714 GO:0051974 IMP involved_in negative regulation of telomerase activity 21531765 Process
6714 GO:0060576 IDA involved_in intestinal epithelial cell development 25731159 Process
6714 GO:0070102 IDA involved_in interleukin-6-mediated signaling pathway 25731159 Process
6714 GO:0070555 IMP involved_in response to interleukin-1 19281832 Process
6714 GO:0071902 IDA involved_in positive regulation of protein serine/threonine kinase activity 19059439 Process
6714 GO:2000394 IMP involved_in positive regulation of lamellipodium morphogenesis 18054784 Process
6714 GO:2000641 IMP involved_in regulation of early endosome to late endosome transport 21724833 Process
6714 GO:2000811 IMP involved_in negative regulation of anoikis 22402981 Process
6714 GO:2001237 IMP involved_in negative regulation of extrinsic apoptotic signaling pathway 19767770 Process
6714 GO:2001243 IMP involved_in negative regulation of intrinsic apoptotic signaling pathway 19767770 Process
6714 GO:2001286 IMP involved_in regulation of caveolin-mediated endocytosis 21724833 Process