Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 7046
  • Symbol: TGFBR1
  • Description: transforming growth factor beta receptor 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
7046 GO:0001837 IDA involved_in epithelial to mesenchymal transition 15761148 Process
7046 GO:0006355 IDA involved_in regulation of DNA-templated transcription 14517293 Process
7046 GO:0006355 IMP involved_in regulation of DNA-templated transcription 15702480 Process
7046 GO:0006468 IDA involved_in protein phosphorylation 9311995,12015308,12065756 Process
7046 GO:0007165 IDA involved_in signal transduction 14633705 Process
7046 GO:0007179 IDA involved_in transforming growth factor beta receptor signaling pathway 1333888,9389648,11157754 Process
7046 GO:0007179 IMP involved_in transforming growth factor beta receptor signaling pathway 1333888 Process
7046 GO:0008284 IMP involved_in positive regulation of cell population proliferation 14633705 Process
7046 GO:0010628 IMP involved_in positive regulation of gene expression 27162619 Process
7046 GO:0010862 IDA involved_in positive regulation of pathway-restricted SMAD protein phosphorylation 9311995,9389648,12065756 Process
7046 GO:0018105 IDA involved_in peptidyl-serine phosphorylation 15761148 Process
7046 GO:0018107 IDA involved_in peptidyl-threonine phosphorylation 19736306 Process
7046 GO:0030307 IDA involved_in positive regulation of cell growth 18625725 Process
7046 GO:0030335 IDA involved_in positive regulation of cell migration 19736306 Process
7046 GO:0031396 IDA involved_in regulation of protein ubiquitination 18758450 Process
7046 GO:0036446 IMP involved_in myofibroblast differentiation 28251559 Process
7046 GO:0043410 IDA acts_upstream_of positive regulation of MAPK cascade 18625725 Process
7046 GO:0045893 IDA involved_in positive regulation of DNA-templated transcription 9311995,9389648 Process
7046 GO:0048870 IMP involved_in cell motility 18625725 Process
7046 GO:0051897 IDA involved_in positive regulation of protein kinase B signaling 18625725 Process
7046 GO:0060389 IDA involved_in pathway-restricted SMAD protein phosphorylation 11157754,12015308,18625725,19736306 Process
7046 GO:0060391 IDA involved_in positive regulation of SMAD protein signal transduction 9389648 Process
7046 GO:0070723 IDA involved_in response to cholesterol 17878231 Process
7046 GO:0071560 IDA involved_in cellular response to transforming growth factor beta stimulus 19494318 Process
7046 GO:1901203 IMP acts_upstream_of positive regulation of extracellular matrix assembly 28251559 Process
7046 GO:2001235 IDA involved_in positive regulation of apoptotic signaling pathway 18758450 Process
7046 GO:2001237 IMP involved_in negative regulation of extrinsic apoptotic signaling pathway 18625725 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
7046 GO:0004672 IDA enables protein kinase activity 19736306 Function
7046 GO:0004674 IDA enables protein serine/threonine kinase activity 12065756,18625725 Function
7046 GO:0005024 IDA enables transforming growth factor beta receptor activity 12015308,14633705 Function
7046 GO:0005024 IMP contributes_to transforming growth factor beta receptor activity 1333888 Function
7046 GO:0005024 IMP enables transforming growth factor beta receptor activity 18625725 Function
7046 GO:0005025 IDA enables transforming growth factor beta receptor activity, type I 8752209 Function
7046 GO:0005114 IDA enables type II transforming growth factor beta receptor binding 11157754 Function
7046 GO:0005114 IPI enables type II transforming growth factor beta receptor binding 1333888 Function
7046 GO:0005515 IPI enables protein binding 8622651,10025408,11278302,11279102,11583628,12015308,14517293,..... Function
7046 GO:0005524 IDA enables ATP binding 12065756 Function
7046 GO:0019838 IPI contributes_to growth factor binding 14517293 Function
7046 GO:0046332 IDA enables SMAD binding 12065756,18625725 Function
7046 GO:0046332 IPI enables SMAD binding 8980228,9311995 Function
7046 GO:0050431 IDA contributes_to transforming growth factor beta binding 11157754 Function
7046 GO:0050431 IDA enables transforming growth factor beta binding 14633705 Function
7046 GO:0050431 IMP contributes_to transforming growth factor beta binding 1333888 Function
7046 GO:0050431 IPI enables transforming growth factor beta binding 1326540 Function
7046 GO:0070411 IPI enables I-SMAD binding 11278251 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
7046 GO:0005634 IDA located_in nucleus 26583432 Component
7046 GO:0005768 IDA located_in endosome 26583432 Component
7046 GO:0005886 IDA located_in plasma membrane 17878231,25893292 Component
7046 GO:0005923 IDA located_in bicellular tight junction 15761148 Component
7046 GO:0009986 IDA located_in cell surface 25893292 Component
7046 GO:0043235 IDA part_of receptor complex 8774881,14517293 Component
7046 GO:0045121 IDA located_in membrane raft 25893292 Component
7046 GO:0070021 IPI part_of transforming growth factor beta ligand-receptor complex 18243111,20207738 Component