Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 84444
  • Symbol: DOT1L
  • Description: DOT1 like histone lysine methyltransferase

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
84444 GO:0003676 EXP enables nucleic acid binding 12628190 Function
84444 GO:0005515 IPI enables protein binding 20153263,20203130,23260655,26496610 Function
84444 GO:0042054 IDA enables histone methyltransferase activity 15851025,17707234 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
84444 GO:0005634 IDA located_in nucleus 15851025 Component
84444 GO:0005654 IDA located_in nucleoplasm Component
84444 GO:0032991 IDA part_of protein-containing complex 15851025 Component
84444 GO:0043231 IDA located_in intracellular membrane-bounded organelle Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
84444 GO:0008284 IDA acts_upstream_of_or_within positive regulation of cell population proliferation 15851025 Process
84444 GO:0034729 IDA acts_upstream_of_or_within histone H3-K79 methylation 15851025 Process
84444 GO:0045944 IDA acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 15851025 Process
84444 GO:0045944 IMP involved_in positive regulation of transcription by RNA polymerase II 22002246 Process
84444 GO:0046425 IDA involved_in regulation of receptor signaling pathway via JAK-STAT 22002246 Process
84444 GO:2000677 IMP involved_in regulation of transcription regulatory region DNA binding 22002246 Process