Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 8737
  • Symbol: RIPK1
  • Description: receptor interacting serine/threonine kinase 1

Process

Export (tab separated) Export to Excel
GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
8737 GO:0001934 IMP involved_in positive regulation of protein phosphorylation 17389591 Process
8737 GO:0006915 IMP involved_in apoptotic process 21737330,22891283,29440439 Process
8737 GO:0006979 IMP involved_in response to oxidative stress 20550618 Process
8737 GO:0010628 IDA involved_in positive regulation of gene expression 26020802 Process
8737 GO:0030163 IDA involved_in protein catabolic process 17389591 Process
8737 GO:0032757 IDA involved_in positive regulation of interleukin-8 production 16127453 Process
8737 GO:0032760 IDA involved_in positive regulation of tumor necrosis factor production 16127453 Process
8737 GO:0034612 IMP involved_in response to tumor necrosis factor 10521396 Process
8737 GO:0036289 IDA involved_in peptidyl-serine autophosphorylation 23473668 Process
8737 GO:0036289 IMP involved_in peptidyl-serine autophosphorylation 31827280 Process
8737 GO:0043065 IDA involved_in positive regulation of apoptotic process 8612133,17389591 Process
8737 GO:0043065 IMP involved_in positive regulation of apoptotic process 22173242 Process
8737 GO:0043068 IMP involved_in positive regulation of programmed cell death 16611992 Process
8737 GO:0043123 IDA involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling 17389591 Process
8737 GO:0043123 IEP involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling 12761501 Process
8737 GO:0043124 IMP involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling 17047155 Process
8737 GO:0045651 IMP involved_in positive regulation of macrophage differentiation 17047155 Process
8737 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 16127453,17389591 Process
8737 GO:0046330 IDA involved_in positive regulation of JNK cascade 17389591 Process
8737 GO:0046777 IDA involved_in protein autophosphorylation 8612133 Process
8737 GO:0046777 IMP involved_in protein autophosphorylation 29440439 Process
8737 GO:0050729 IMP involved_in positive regulation of inflammatory response 31827280 Process
8737 GO:0051092 IMP involved_in positive regulation of NF-kappaB transcription factor activity 8612133,10521396,21931591 Process
8737 GO:0060545 IMP involved_in positive regulation of necroptotic process 22028622,22274400,22817896 Process
8737 GO:0062100 IMP involved_in positive regulation of programmed necrotic cell death 20550618 Process
8737 GO:0070105 IMP involved_in positive regulation of interleukin-6-mediated signaling pathway 31827280 Process
8737 GO:0070266 IMP involved_in necroptotic process 21737330,22265414,29440439,30988283 Process
8737 GO:0070926 IMP involved_in regulation of ATP:ADP antiporter activity 16507998 Process
8737 GO:0071356 IDA involved_in cellular response to tumor necrosis factor 17389591 Process
8737 GO:0097191 IDA involved_in extrinsic apoptotic signaling pathway 7538908 Process
8737 GO:0097191 IMP involved_in extrinsic apoptotic signaling pathway 8612133,10521396 Process
8737 GO:0097343 IMP involved_in ripoptosome assembly 21737330 Process
8737 GO:0097527 IMP involved_in necroptotic signaling pathway 11101870,16507998,22265413,22817896,31827280 Process
8737 GO:1990000 IMP involved_in amyloid fibril formation 22817896 Process
8737 GO:2001237 IMP involved_in negative regulation of extrinsic apoptotic signaling pathway 21525013 Process
8737 GO:2001238 IMP involved_in positive regulation of extrinsic apoptotic signaling pathway 21525013,22274400 Process

Function

Export (tab separated) Export to Excel
GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
8737 GO:0004672 IDA enables protein kinase activity 15001576,22265413 Function
8737 GO:0004672 IMP enables protein kinase activity 22817896 Function
8737 GO:0004674 IDA enables protein serine/threonine kinase activity 8612133,23473668 Function
8737 GO:0004674 IMP enables protein serine/threonine kinase activity 30988283,31827280 Function
8737 GO:0005123 IPI enables death receptor binding 7538908 Function
8737 GO:0005515 IPI enables protein binding 10356400,12884866,12887920,14653779,16127453,16611992,17047155..... Function
8737 GO:0031625 IPI enables ubiquitin protein ligase binding 18450452 Function
8737 GO:0042802 IPI enables identical protein binding 22817896,23473668,25416956,32296183 Function
8737 GO:0042803 IDA enables protein homodimerization activity 29440439 Function
8737 GO:0044877 IDA enables protein-containing complex binding 22265414 Function
8737 GO:0070513 IPI enables death domain binding 8612133,9044836 Function

Component

Export (tab separated) Export to Excel
GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
8737 GO:0005739 IDA located_in mitochondrion 16507998 Component
8737 GO:0031264 IDA part_of death-inducing signaling complex 11101870 Component
8737 GO:0032991 IDA part_of protein-containing complex 22817896 Component
8737 GO:0043235 IDA part_of receptor complex 8612133 Component
8737 GO:0097342 IDA part_of ripoptosome 21737330 Component