Gene Ontology

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 8837
• Symbol: CFLAR
• Description: CASP8 and FADD like apoptosis regulator

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
8837	GO:0002020	IPI	enables	protease binding	9208847	Function
8837	GO:0005515	IPI	enables	protein binding	9208847,11741985,12887920,17047155,23541952,24438025,25241761,.....	Function
8837	GO:0008047	IDA	enables	enzyme activator activity	9208847	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
8837	GO:0005737	IDA	located_in	cytoplasm	18073330	Component
8837	GO:0031264	IDA	part_of	death-inducing signaling complex	21803845	Component
8837	GO:0097342	IDA	part_of	ripoptosome	21737330	Component

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
8837	GO:0006915	IMP	involved_in	apoptotic process	21737330	Process
8837	GO:0043123	IEP	involved_in	positive regulation of I-kappaB kinase/NF-kappaB signaling	12761501	Process
8837	GO:0060544	IDA	involved_in	regulation of necroptotic process	21737330	Process
8837	GO:1902042	IDA	acts_upstream_of_or_within	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	26582200	Process
8837	GO:1902042	IMP	involved_in	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	18202225	Process
8837	GO:2001237	IDA	involved_in	negative regulation of extrinsic apoptotic signaling pathway	9208847	Process
8837	GO:2001237	IMP	involved_in	negative regulation of extrinsic apoptotic signaling pathway	22266862	Process