Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 9978
  • Symbol: RBX1
  • Description: ring-box 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9978 GO:0000209 IDA involved_in protein polyubiquitination 14528312 Process
9978 GO:0006511 IDA involved_in ubiquitin-dependent protein catabolic process 17636018 Process
9978 GO:0006513 IDA involved_in protein monoubiquitination 22358839 Process
9978 GO:0006974 EXP involved_in DNA damage response 22118460 Process
9978 GO:0007283 IDA involved_in spermatogenesis 34065512 Process
9978 GO:0016567 IDA involved_in protein ubiquitination 15103331,17543862,20389280 Process
9978 GO:0016567 IPI involved_in protein ubiquitination 14739464 Process
9978 GO:0031146 IDA involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 15103331 Process
9978 GO:0032436 IPI involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process 14739464 Process
9978 GO:0032480 IDA involved_in negative regulation of type I interferon production 36394357 Process
9978 GO:0034644 EXP involved_in cellular response to UV 22118460 Process
9978 GO:0042110 IDA involved_in T cell activation 34065512 Process
9978 GO:0043161 IDA involved_in proteasome-mediated ubiquitin-dependent protein catabolic process 20389280,34480022 Process
9978 GO:0045116 IDA involved_in protein neddylation 19250909 Process
9978 GO:0045732 IDA involved_in positive regulation of protein catabolic process 11027288,16482215,27626656 Process
9978 GO:0070936 IDA involved_in protein K48-linked ubiquitination 15103331,25684205 Process
9978 GO:0140627 IDA involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway 34065512 Process
9978 GO:1902499 IMP involved_in positive regulation of protein autoubiquitination 14528312 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9978 GO:0004842 IDA contributes_to ubiquitin-protein transferase activity 15983046,20389280 Function
9978 GO:0005515 IPI enables protein binding 11961546,12504026,12609982,15601820,17183367,18239684,18805092..... Function
9978 GO:0031625 IDA enables ubiquitin protein ligase binding 17636018 Function
9978 GO:0034450 IDA enables ubiquitin-ubiquitin ligase activity 10230407 Function
9978 GO:0060090 EXP enables molecular adaptor activity 11961546 Function
9978 GO:0061629 IPI enables RNA polymerase II-specific DNA-binding transcription factor binding 14739464 Function
9978 GO:0061630 IDA enables ubiquitin protein ligase activity 10230407,11027288,16482215,17636018,20870715,22405651,27626656..... Function
9978 GO:0061663 IDA enables NEDD8 ligase activity 19250909 Function
9978 GO:0097602 IDA enables cullin family protein binding 10230407 Function
9978 GO:0097602 IPI enables cullin family protein binding 14528312 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9978 GO:0005634 IDA is_active_in nucleus 11027288 Component
9978 GO:0005654 IDA located_in nucleoplasm Component
9978 GO:0005737 IDA is_active_in cytoplasm 34065512 Component
9978 GO:0019005 IDA part_of SCF ubiquitin ligase complex 11956208,15103331,21572392,23263282,25585578 Component
9978 GO:0031461 IDA part_of cullin-RING ubiquitin ligase complex 22405651 Component
9978 GO:0031462 IDA part_of Cul2-RING ubiquitin ligase complex 17636018 Component
9978 GO:0031463 IDA part_of Cul3-RING ubiquitin ligase complex 14528312,15983046,17543862,20389280,22358839 Component
9978 GO:0031464 EXP part_of Cul4A-RING E3 ubiquitin ligase complex 22118460 Component
9978 GO:0031464 IDA part_of Cul4A-RING E3 ubiquitin ligase complex 12732143,14739464,17085480,18794347,20129063,20223979..... Component
9978 GO:0031465 IDA part_of Cul4B-RING E3 ubiquitin ligase complex 18794347 Component
9978 GO:0031466 IDA part_of Cul5-RING ubiquitin ligase complex 17636018 Component
9978 GO:0031467 IDA part_of Cul7-RING ubiquitin ligase complex 18498745 Component