Crispr

Gene Info

• Species: Human (Homo sapiens)
• GeneID: 383
• Symbol: ARG1
• Description: arginase 1

DataSource: http://genomecrispr.dkfz.de/#!/results/ARG1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
131573322	131573345	6	-	26627737	DLD1	viability	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	0.30203168688313853	[746]	[278,447,162]	3	hSpCas9	negative selection	830506
131573322	131573345	6	-	26627737	GBM cells	viability after 5 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	0.2975497672250398	[574]	[284,472]	4	hSpCas9	negative selection	912821
131573322	131573345	6	-	26627737	GBM cells	viability after 13 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	0.42584581355646534	[574]	[417,419]	5	hSpCas9	negative selection	995136
131573322	131573345	6	-	26627737	GBM cells	viability after 21 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	0.6951749946481904	[574]	[510,500]	7	hSpCas9	negative selection	1077451
131573322	131573345	6	-	26627737	RPE1	viability after 9 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	0.25136394488195646	[1593]	[476,744]	1	hSpCas9	negative selection	1159766
131573322	131573345	6	-	26627737	RPE1	viability after 12 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	0.36888570461449843	[1593]	[553,551]	2	hSpCas9	negative selection	1242081
131573322	131573345	6	-	26627737	RPE1	viability after 15 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	-0.14486182587763363	[1593]	[332,479]	-1	hSpCas9	negative selection	1324396
131573322	131573345	6	-	26627737	RPE1	viability after 18 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	0.1867116452213109	[1593]	[550,423]	1	hSpCas9	negative selection	1406711
131573322	131573345	6	-	26627737	HeLa	viability after 8 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	0.08416557468857289	[722]	[638,187,246]	0	hSpCas9	negative selection	1489026
131573322	131573345	6	-	26627737	HeLa	viability after 12 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	-0.1885511937044625	[722]	[266,230,291]	-2	hSpCas9	negative selection	1571341
131573322	131573345	6	-	26627737	HeLa	viability after 15 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	-0.11253587926078279	[722]	[288,309,212]	-1	hSpCas9	negative selection	1653656
131573322	131573345	6	-	26627737	HeLa	viability after 18 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	-0.15752725302620307	[722]	[186,244,212]	-1	hSpCas9	negative selection	1735971
131573322	131573345	6	-	26627737	HCT116	viability after 6 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	0.9095837003425348	[908]	[562,105]	5	hSpCas9	negative selection	1818286
131573322	131573345	6	-	26627737	HCT116	viability after 8 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	-0.2629866000800979	[653]	[297,391,211]	-3	hSpCas9	negative selection	1900601
131573322	131573345	6	-	26627737	HCT116	viability after 9 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	0.46079108432214844	[908]	[323,341]	3	hSpCas9	negative selection	1982916
131573322	131573345	6	-	26627737	HCT116	viability after 12 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	-0.2601770727702145	[653]	[328,317,210]	-3	hSpCas9	negative selection	2065231
131573322	131573345	6	-	26627737	HCT116	viability after 15 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	-0.738052865412358	[653]	[247,260,169]	-6	hSpCas9	negative selection	2147546
131573322	131573345	6	-	26627737	HCT116	viability after 18 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	-1.039034113978046	[653]	[157,105,202]	-7	hSpCas9	negative selection	2229861
131573288	131573311	6	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCGCCAAGTCCAGAACCATAGGG	ARG1	ENSG00000118520	0.28417391306681294	[4,4]	[3,4]	6	hSpCas9	positive selection	2971217
131573288	131573311	6	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCGCCAAGTCCAGAACCATAGGG	ARG1	ENSG00000118520	0.11956139251627185	[4,4]	[3,3]	2	hSpCas9	positive selection	3039075
131573287	131573310	6	+	26780180	HT29	viability (Avana library 4 designs)	GCGCCAAGTCCAGAACCATAGGG	ARG1	ENSG00000118520	0.502681647316719	[]	[]	2	hSpCas9	negative selection	3407333
131573287	131573310	6	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCGCCAAGTCCAGAACCATAGGG	ARG1	ENSG00000118520	2.48988829078651	[]	[]	3	hSpCas9	negative selection	3480326
131573287	131573310	6	+	26780180	A375	viability (Avana lentiGuide)	GCGCCAAGTCCAGAACCATAGGG	ARG1	ENSG00000118520	-4.44218938946896	[]	[]	-7	hSpCas9	negative selection	3588985
131573287	131573310	6	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCGCCAAGTCCAGAACCATAGGG	ARG1	ENSG00000118520	0.08857850695166394	[5]	[5,4]	2	hSpCas9	positive selection	3697644
131573287	131573310	6	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCGCCAAGTCCAGAACCATAGGG	ARG1	ENSG00000118520	0.22628020964417037	[5]	[5,6]	6	hSpCas9	positive selection	3806251
131573226	131573249	6	+	27661255	K562	viability	GTCACTGAGGGTTGACTGACTGG	ARG1	ENSG00000118520	0.12504640228748662	[695,631]	[620,543]	4	dCas9-KRAB	negative selection	5463084
131573527	131573550	6	+	27661255	K562	viability	GTGGCTCGTGATCTCAGCCAAGG	ARG1	ENSG00000118520	-0.08050903401433696	[1338,1401]	[1088,987]	-3	dCas9-KRAB	negative selection	5463085
131573322	131573345	6	-	27869803	HPAFII	viability after 27 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	0.5798739182972347	[384]	[265,332,NaN]	5	hSpCas9	negative selection	9593610
131573322	131573345	6	-	27869803	HPAFII	viability after 15 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	0.5244467227302204	[384]	[707,524,NaN]	6	hSpCas9	negative selection	9676059
131573322	131573345	6	-	27869803	ASPC1	viability after 36 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	0.24066851138361167	[977]	[551,377,314]	2	hSpCas9	negative selection	9758508
131573322	131573345	6	-	27869803	PATU8988S	viability after 35 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	-0.09663452668912687	[910]	[401,283,NaN]	-1	hSpCas9	negative selection	9840957
131573322	131573345	6	-	27869803	PATU8988S	viability after 31 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	-0.04540843371474945	[910]	[351,351,NaN]	0	hSpCas9	negative selection	9923406
131573322	131573345	6	-	27869803	HPAFII	viability after 35 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	0.609324102099373	[384]	[262,335,NaN]	4	hSpCas9	negative selection	10005855
131573322	131573345	6	-	27869803	HPAFII	viability after 31 days	CTTACCTGTCCCTTTGAGAAAGG	ARG1	ENSG00000118520	0.5042989600040949	[384]	[238,379,NaN]	3	hSpCas9	negative selection	10088304