Gene2Function

Crispr

Gene Info

Species: Human (Homo sapiens)
GeneID: 6098
Symbol: ROS1
Description: ROS proto-oncogene 1, receptor tyrosine kinase

DataSource: http://genomecrispr.dkfz.de/#!/results/ROS1

Export (tab separated) Export to Excel

Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
117300997	117301020	6	-	26472758	Jiyoye	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	1.8174593508140826	[75]	[201]	8	hSpCas9	negative selection	138931
117300997	117301020	6	-	26472758	KBM7	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	0.6468127442952063	[376,557]	[481,236]	7	hSpCas9	negative selection	330049
117300997	117301020	6	-	26472758	Raji	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	-0.07040358384168321	[275]	[60]	0	hSpCas9	negative selection	521167
117300997	117301020	6	-	26472758	K562	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	1.0111050199526528	[441]	[751]	8	hSpCas9	negative selection	712285
117300999	117301022	6	+	27383988	293T	resistance to West Nile virus (flavivirus)	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.9152515434466966	[648,648]	[7,7]	4	hSpCas9	positive selection	3390336
117300999	117301022	6	+	26780180	A375	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.441815652224229	[]	[]	1	hSpCas9	negative selection	3990079
117301113	117301136	6	-	26780180	A375	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	1.23012010319734	[]	[]	6	hSpCas9	negative selection	3990080
117300999	117301022	6	+	26780180	HT29	viability (GeCKOv2 library)	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.657317654438455	[]	[]	2	hSpCas9	negative selection	4098045
117301113	117301136	6	-	26780180	HT29	viability (GeCKOv2 library)	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	1.40935300382184	[]	[]	7	hSpCas9	negative selection	4098046
117301113	117301136	6	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	-0.01750417826842607	[3]	[3,1]	0	hSpCas9	positive selection	4295415
117300999	117301022	6	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.37436801475207543	[4]	[4,4]	7	hSpCas9	positive selection	4359670
117301113	117301136	6	-	27260156	BXPC3	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	-0.012595898001907857	[791]	[776,835,848,819]	0	hSpCas9	negative selection	5567875
117300999	117301022	6	+	27260156	BXPC3	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.36836452682213006	[1427]	[1610,1975,1969,2205]	7	hSpCas9	negative selection	5632130
117301113	117301136	6	-	27260156	A673	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	-0.01009978773810949	[791]	[1064,920,900,900]	0	hSpCas9	negative selection	5689126
117300999	117301022	6	+	27260156	A673	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.31643332721052975	[1427]	[2255,1735,2489,2071]	7	hSpCas9	negative selection	5753381
117301113	117301136	6	-	27260156	A375	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.08761550865792944	[791]	[927,1049,800,1138]	1	hSpCas9	negative selection	5810377
117300999	117301022	6	+	27260156	A375	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.5957560065676524	[1427]	[2141,3007,2645,2360]	8	hSpCas9	negative selection	5874632
117301113	117301136	6	-	27260156	COLO741	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	-0.0018362494635465465	[791]	[1032,1035,965]	0	hSpCas9	negative selection	5931628
117300999	117301022	6	+	27260156	COLO741	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.31023116807844775	[1427]	[2234,2246,2294]	6	hSpCas9	negative selection	5995883
117301113	117301136	6	-	27260156	CAL120	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	-0.08149766944711756	[791]	[735,1125,902]	-1	hSpCas9	negative selection	6052879
117300999	117301022	6	+	27260156	CAL120	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.5288429914750554	[1427]	[2610,3003,2090]	7	hSpCas9	negative selection	6117134
117301113	117301136	6	-	27260156	CADOES1	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.09766406767634117	[791]	[848,773,858,665]	1	hSpCas9	negative selection	6174130
117300999	117301022	6	+	27260156	CADOES1	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.41689046788425044	[1427]	[1699,1946,1901,1534]	7	hSpCas9	negative selection	6238385
117301113	117301136	6	-	27260156	EWS502	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	-0.2094411122172235	[791]	[672,658,853,723]	-4	hSpCas9	negative selection	6295381
117300999	117301022	6	+	27260156	EWS502	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.2887237882371141	[1427]	[1552,2038,1699,2137]	5	hSpCas9	negative selection	6359636
117301113	117301136	6	-	27260156	EW8	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	-0.09560742324727067	[791]	[635,628,481,677]	-2	hSpCas9	negative selection	6416632
117300999	117301022	6	+	27260156	EW8	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.30787228975745506	[1427]	[1665,1644,1042,1464]	5	hSpCas9	negative selection	6480887
117301113	117301136	6	-	27260156	CORL105	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.29594723278885793	[791]	[1092,1184,1173,1103]	5	hSpCas9	negative selection	6537883
117300999	117301022	6	+	27260156	CORL105	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.2614244649916515	[1427]	[2078,2073,2125,1756]	5	hSpCas9	negative selection	6602138
117301113	117301136	6	-	27260156	HS294T	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.20384660355167417	[791]	[356,388,283,382]	2	hSpCas9	negative selection	6659134
117300999	117301022	6	+	27260156	HS294T	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.47738070724124615	[1427]	[598,694,719,1138]	6	hSpCas9	negative selection	6723389
117301113	117301136	6	-	27260156	HCC44	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.05222100812516406	[791]	[1127,681,969,985]	0	hSpCas9	negative selection	6780385
117300999	117301022	6	+	27260156	HCC44	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.31508272258609815	[1427]	[2535,1513,2209,1916]	5	hSpCas9	negative selection	6844640
117301113	117301136	6	-	27260156	G402	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.004962726016256913	[791]	[842,926,1551,552]	0	hSpCas9	negative selection	6901636
117300999	117301022	6	+	27260156	G402	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.4362066938916138	[1427]	[2044,2582,2483,2280]	5	hSpCas9	negative selection	6965891
117301113	117301136	6	-	27260156	L33	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.13244139290577606	[791]	[752,355,592,909]	3	hSpCas9	negative selection	7022887
117300999	117301022	6	+	27260156	L33	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.12807848533351907	[1427]	[1723,599,967,1509]	3	hSpCas9	negative selection	7087142
117301113	117301136	6	-	27260156	K562	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.2648198657538896	[791]	[754,1596,573,518]	3	hSpCas9	negative selection	7144138
117300999	117301022	6	+	27260156	K562	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.44289966833624206	[1427]	[1740,2103,1651,1440]	5	hSpCas9	negative selection	7208393
117301113	117301136	6	-	27260156	HT29	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	-0.22596589751135898	[791]	[813,865,869,748]	-4	hSpCas9	negative selection	7265389
117300999	117301022	6	+	27260156	HT29	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.3829589612366211	[1427]	[2236,2449,2415,1983]	7	hSpCas9	negative selection	7329644
117301113	117301136	6	-	27260156	MHHES1	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	-0.017210233043368883	[791]	[1103,928,1120,479]	0	hSpCas9	negative selection	7386640
117300999	117301022	6	+	27260156	MHHES1	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.1129867445083026	[1427]	[1944,2195,1762,1209]	2	hSpCas9	negative selection	7450895
117301113	117301136	6	-	27260156	MEWO	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.05910208970299735	[791]	[866,585,881]	1	hSpCas9	negative selection	7507891
117300999	117301022	6	+	27260156	MEWO	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.2662425393495531	[1427]	[1903,1703,1268]	6	hSpCas9	negative selection	7572146
117301113	117301136	6	-	27260156	LNCAPCLONEFGC	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.03606786922308991	[791]	[583,734,978,682]	0	hSpCas9	negative selection	7629142
117300999	117301022	6	+	27260156	LNCAPCLONEFGC	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.4234774764167226	[1427]	[1867,1706,1892,1492]	6	hSpCas9	negative selection	7693397
117301113	117301136	6	-	27260156	PANC0327	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.20380300423778763	[791]	[754,687,1217,591]	3	hSpCas9	negative selection	7750393
117300999	117301022	6	+	27260156	PANC0327	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.2614654765956641	[1427]	[1572,1525,1784,1201]	4	hSpCas9	negative selection	7814648
117301113	117301136	6	-	27260156	NCIH2009	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.17272027091712505	[791]	[1433,1226,1115]	2	hSpCas9	negative selection	7871644
117300999	117301022	6	+	27260156	NCIH2009	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.5191319630017182	[1427]	[3113,2647,2864]	7	hSpCas9	negative selection	7935899
117301113	117301136	6	-	27260156	NCIH1373	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.3262010362447234	[791]	[1083,961,1313,286]	3	hSpCas9	negative selection	7992895
117300999	117301022	6	+	27260156	NCIH1373	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.9942353625866622	[1427]	[3217,2873,3123,941]	8	hSpCas9	negative selection	8057150
117301113	117301136	6	-	27260156	PATU8902	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	-0.28539137982623375	[791]	[685,932,689,1424]	-3	hSpCas9	negative selection	8114146
117300999	117301022	6	+	27260156	PATU8902	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.6253851821470624	[1427]	[3651,2750,2066,4158]	6	hSpCas9	negative selection	8178401
117301113	117301136	6	-	27260156	PANC1	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.35412728332347365	[791]	[874,1062,683,877]	6	hSpCas9	negative selection	8235397
117300999	117301022	6	+	27260156	PANC1	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.5840571043336786	[1427]	[1597,2197,1925,1703]	8	hSpCas9	negative selection	8299652
117301113	117301136	6	-	27260156	PANC0813	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.1888871820879615	[791]	[947,1273,1032,978]	3	hSpCas9	negative selection	8356648
117300999	117301022	6	+	27260156	PANC0813	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.13997871607979095	[1427]	[1826,1920,2034,1618]	2	hSpCas9	negative selection	8420903
117301113	117301136	6	-	27260156	RDES	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	-0.07632937850602617	[791]	[695,782,995,1028]	-1	hSpCas9	negative selection	8477899
117300999	117301022	6	+	27260156	RDES	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.29467175042482086	[1427]	[1708,1917,2092,2413]	5	hSpCas9	negative selection	8542154
117301113	117301136	6	-	27260156	PC3	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.13969478119978596	[791]	[518,639,1909,904]	3	hSpCas9	negative selection	8599150
117300999	117301022	6	+	27260156	PC3	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.26947542564414784	[1427]	[984,1586,2681,2178]	6	hSpCas9	negative selection	8663405
117301113	117301136	6	-	27260156	PATU8988T	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.029735503040702937	[791]	[626,777,890,830]	0	hSpCas9	negative selection	8720401
117300999	117301022	6	+	27260156	PATU8988T	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.3192773046728754	[1427]	[1787,1867,1718,1507]	5	hSpCas9	negative selection	8784656
117301113	117301136	6	-	27260156	T47D	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	-0.08024206661868583	[791]	[886,957,827,808]	-2	hSpCas9	negative selection	8841652
117300999	117301022	6	+	27260156	T47D	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.3179572956180172	[1427]	[2129,2040,1927,2204]	6	hSpCas9	negative selection	8905907
117301113	117301136	6	-	27260156	SU8686	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.17410661236341896	[791]	[845,643,1032,1086]	3	hSpCas9	negative selection	8962903
117300999	117301022	6	+	27260156	SU8686	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.2054188000193562	[1427]	[1414,1472,1704,2037]	3	hSpCas9	negative selection	9027158
117301113	117301136	6	-	27260156	SKES1	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	-0.2793020415700508	[791]	[634,695,663,609]	-6	hSpCas9	negative selection	9084154
117300999	117301022	6	+	27260156	SKES1	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.20347234906213152	[1427]	[1963,1936,1469,1296]	4	hSpCas9	negative selection	9148409
117301113	117301136	6	-	27260156	TOV112D	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.22901590903269076	[791]	[1103,973,995,675]	4	hSpCas9	negative selection	9205405
117300999	117301022	6	+	27260156	TOV112D	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.23924883432548305	[1427]	[1499,2244,1359,1763]	4	hSpCas9	negative selection	9269660
117301113	117301136	6	-	27260156	TC71	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	-0.09268990153558798	[791]	[864,772,774,768]	-2	hSpCas9	negative selection	9326656
117300999	117301022	6	+	27260156	TC71	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.32352843532438613	[1427]	[1740,2060,1885,1982]	7	hSpCas9	negative selection	9390911
117301113	117301136	6	-	27260156	TC32	viability	GGAATTTAATGACCCAGTGCTGG	ROS1	ENSG00000047936	0.07528549583089694	[791]	[672,813,804,799]	1	hSpCas9	negative selection	9447907
117300999	117301022	6	+	27260156	TC32	viability	ACTGTTGTTTGCTTCATCTCTGG	ROS1	ENSG00000047936	0.49182304339663974	[1427]	[1575,1680,2290,2081]	8	hSpCas9	negative selection	9512162
117300997	117301020	6	-	28162770	P31FUJ	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	0.5053906931358298	[234]	[391]	6	hSpCas9	negative selection	10226974
117300997	117301020	6	-	28162770	TF1	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	NaN	[NaN]	[132]	1	hSpCas9	negative selection	10396340
117300997	117301020	6	-	28162770	SKM1	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	0.17799830197799454	[60]	[121]	1	hSpCas9	negative selection	10565706
117300997	117301020	6	-	28162770	SKM1	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	0.17799830197799454	[60]	[121]	1	hSpCas9	negative selection	10735072
117300997	117301020	6	-	28162770	PL21	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	-1.3528327719873992	[222]	[37]	-7	hSpCas9	negative selection	10904438
117300997	117301020	6	-	28162770	P31FUJ	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	0.5053906931358298	[234]	[391]	6	hSpCas9	negative selection	11073804
117300997	117301020	6	-	28162770	OCIAML5	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	1.2115495284319748	[121]	[509]	8	hSpCas9	negative selection	11243170
117300997	117301020	6	-	28162770	EOL1	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	0.014433275087729736	[279]	[148]	0	hSpCas9	negative selection	11412536
117300997	117301020	6	-	28162770	MOLM13	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	0.29237036362904323	[322]	[285]	2	hSpCas9	negative selection	11581902
117300997	117301020	6	-	28162770	HEL	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	0.1101317363403371	[229]	[158]	0	hSpCas9	negative selection	11751268
117300997	117301020	6	-	28162770	MV411	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	0.08697287858952923	[189]	[169]	0	hSpCas9	negative selection	11920634
117300997	117301020	6	-	28162770	MONOMAC1	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	0.5186601303530013	[122]	[201]	5	hSpCas9	negative selection	12090000
117300997	117301020	6	-	28162770	OCIAML2	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	-0.1818685942899981	[43]	[214]	-1	hSpCas9	negative selection	12259366
117300997	117301020	6	-	28162770	OCIAML3	viability	AGAGATGAAGCAAACAACAGTGG	ROS1	ENSG00000047936	0.4059923596758368	[65]	[263]	4	hSpCas9	negative selection	12428732