GR00053-A |
2521 |
NM_004960 |
FUS |
np |
sp |
none |
|
no |
|
Genome stability |
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. |
Paulsen et al. |
2009 |
19647519 |
Cell line |
HeLa |
gamma-H2AX phosphorylation and DNA content |
Fluorescence |
siARRAY human genome siRNA library |
Genome-wide |
siRNA |
p-value |
Complex criteria |
Confidence groupings from 4 to 1 (highest level of confidence in group 4) |
GR00054-A |
2521 |
NM_004960 |
FUS |
np |
0.927 |
none |
|
no |
|
Combinatorial effect with paclitaxel |
Synthetic lethal screen identification of chemosensitizer loci in cancer cells. |
Whitehurst et al. |
2007 |
17429401 |
Cell line |
NCI-H1155 |
Viability (synthetic lethal) |
ATP level |
# G-005000-01 |
Genome-wide |
siRNA |
Paclitaxel/control ratio |
Complex criteria |
Additional information about 87 high-confidence hits |
GR00056-A |
2521 |
NM_004960 |
FUS |
np |
1.005 |
none |
|
no |
|
Melanogenesis |
Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. |
Ganesan et al. |
2008 |
19057677 |
Cell line |
MNT-1 |
Melanin protein expression and viability |
Absorbance and luminescence |
rp |
Genome-wide |
siRNA |
Normalized absorbance ratio |
> 2 standard deviations below mean |
Additional information about a secondary screen (retest to determine false-positive rate) |
GR00057-A-1 |
2521 |
NM_004960 |
FUS |
M-009497-01 |
3.05 |
none |
|
no |
|
Wnt/beta-catenin pathway regulation (1) |
A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. |
Tang et al. |
2008 |
18621708 |
Cell line |
HeLa |
Wnt pathway reporter |
Luminescence |
Human siArray siRNA library |
Genome-wide |
siRNA |
Z-score |
> 4 |
Screen without Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries). |
GR00057-A-2 |
2521 |
NM_004960 |
FUS |
M-009497-01 |
sp |
none |
|
no |
|
Wnt/beta-catenin pathway regulation (2) |
A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. |
Tang et al. |
2008 |
18621708 |
Cell line |
HeLa |
Wnt pathway reporter |
Luminescence |
Human siArray siRNA library |
Genome-wide |
siRNA |
Complex, SP |
Complex criteria |
Screen with Wnt3A stimulation. Additional information about secondary screens (Dharmacon and Qiagen libraries). |
GR00095-A |
2521 |
NM_004960 |
FUS |
np |
np |
none |
|
|
|
p53 pathway components |
A large-scale RNAi screen in human cells identifies new components of the p53 pathway |
Berns et al. |
2004 |
15042092 |
Cell line |
BJ-TERT-tsLT fibroblasts |
Proliferation |
Colony-forming cell assay |
Nki library |
Genome-wide |
shRNA |
np |
np |
|
GR00096-A |
2521 |
NM_004960 |
|
NM_004960 siRNA1 |
sp |
Increased cell number in G2M, increased nuclei size in G2M |
|
no |
|
Cell-cycle regulation |
Genome-wide functional analysis of human cell-cycle regulators. |
Mukherji et al. |
2006 |
17001007 |
Cell line |
U2OS |
Cell number and nuclei size |
Fluorescence |
Custom-made |
Genome-wide and druggable genes |
siRNA |
Complex, sp |
np |
Additional information about a secondary screen |
GR00098-A-1 |
2521 |
ENSG00000089280 |
FUS |
ENSG00000089280 |
sp |
none |
|
no |
|
Cell division (1) |
Genome-scale RNAi profiling of cell division in human tissue culture cells. |
Kittler et al. |
2007 |
17994010 |
Cell line |
HeLa |
Cell number and DNA content |
Laser scanning cytometry |
rp |
Genome-wide |
esiRNA |
Complex, sp |
Complex criteria |
|
GR00123-A |
2521 |
NM_004960 |
FUS |
162912, 162911, 162913 |
np |
none |
|
|
|
Combinatorial effect with nutlin-3 |
An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors |
Brummelkamp et al. |
2006 |
16474381 |
Cell line |
MCF-7 |
Viability |
Fluoresence |
Nki library |
Genome-wide |
shRNA |
log2 ratio |
np |
|
GR00133-A-1 |
2521 |
2521 |
FUS |
np |
0.19166 |
none |
|
no |
|
Salmonella enterica subspecies 1 serovar Typhimurium invasion (1) |
RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42. |
Misselwitz et al. |
2011 |
21407211 |
Cell line |
HeLa |
Gentamycin protection invasion assay |
Fluorescence |
Druggable genome library V2.0 |
Druggable genes |
siRNA |
log2 median |
Complex criteria |
|
GR00147-A-1 |
2521 |
2521 |
FUS |
np |
np |
Decreased influenza A virus infection |
|
yes |
|
Influenza A virus infection (1) |
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. |
Brass et al. |
2009 |
20064371 |
Cell line |
U2OS |
Viral hemagglutinin protein surface expression |
Fluorescence |
siARRAY siRNA Library |
Genome-wide |
siRNA |
Percentage of viral hemagglutinin positive cells |
Complex criteria |
|
GR00147-A-2 |
2521 |
2521 |
FUS |
D-009497-04 |
0.52 |
Decreased influenza A virus infection |
50 nM siRNA concentration |
no |
|
Influenza A virus infection (2) |
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. |
Brass et al. |
2009 |
20064371 |
rp |
rp |
rp |
rp |
rp |
Selected genes |
siRNA |
Percentage of infected cells |
Complex criteria |
|
GR00147-A-2 |
2521 |
2521 |
FUS |
D-009497-06 |
0.25 |
Decreased influenza A virus infection |
50 nM siRNA concentration |
no |
|
Influenza A virus infection (2) |
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. |
Brass et al. |
2009 |
20064371 |
rp |
rp |
rp |
rp |
rp |
Selected genes |
siRNA |
Percentage of infected cells |
Complex criteria |
|
GR00147-A-2 |
2521 |
2521 |
FUS |
D-009497-05 |
0.55 |
Decreased influenza A virus infection |
50 nM siRNA concentration |
no |
|
Influenza A virus infection (2) |
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. |
Brass et al. |
2009 |
20064371 |
rp |
rp |
rp |
rp |
rp |
Selected genes |
siRNA |
Percentage of infected cells |
Complex criteria |
|
GR00147-A-2 |
2521 |
2521 |
FUS |
D-009497-02 |
0.85 |
none |
50 nM siRNA concentration |
no |
|
Influenza A virus infection (2) |
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. |
Brass et al. |
2009 |
20064371 |
rp |
rp |
rp |
rp |
rp |
Selected genes |
siRNA |
Percentage of infected cells |
Complex criteria |
|
GR00149-A-1 |
2521 |
2521 |
FUS |
15494 |
-46.57 |
none |
|
no |
|
Ciliogenesis and cilium length (1) |
Functional genomic screen for modulators of ciliogenesis and cilium length. |
Kim et al. |
2010 |
20393563 |
Cell line |
htRPE |
Smoothed protein expression |
Fluorescence |
Human druggable genome siRNA library V3.1 |
Druggable genes |
siRNA |
Normalized percent inhibition |
> 1.5 OR < -1.5 standard deviations from mean |
|
GR00149-A-1 |
2521 |
2521 |
FUS |
15494 |
-24.16 |
none |
|
no |
|
Ciliogenesis and cilium length (1) |
Functional genomic screen for modulators of ciliogenesis and cilium length. |
Kim et al. |
2010 |
20393563 |
Cell line |
htRPE |
Smoothed protein expression |
Fluorescence |
Human druggable genome siRNA library V3.1 |
Druggable genes |
siRNA |
Normalized percent inhibition |
> 1.5 OR < -1.5 standard deviations from mean |
|
GR00149-A-1 |
2521 |
2521 |
FUS |
121512 |
-3.48 |
none |
|
no |
|
Ciliogenesis and cilium length (1) |
Functional genomic screen for modulators of ciliogenesis and cilium length. |
Kim et al. |
2010 |
20393563 |
Cell line |
htRPE |
Smoothed protein expression |
Fluorescence |
Human druggable genome siRNA library V3.1 |
Druggable genes |
siRNA |
Normalized percent inhibition |
> 1.5 OR < -1.5 standard deviations from mean |
|
GR00149-A-1 |
2521 |
2521 |
FUS |
121512 |
11.53 |
none |
|
no |
|
Ciliogenesis and cilium length (1) |
Functional genomic screen for modulators of ciliogenesis and cilium length. |
Kim et al. |
2010 |
20393563 |
Cell line |
htRPE |
Smoothed protein expression |
Fluorescence |
Human druggable genome siRNA library V3.1 |
Druggable genes |
siRNA |
Normalized percent inhibition |
> 1.5 OR < -1.5 standard deviations from mean |
|
GR00149-A-1 |
2521 |
2521 |
FUS |
121513 |
-11.09 |
none |
|
no |
|
Ciliogenesis and cilium length (1) |
Functional genomic screen for modulators of ciliogenesis and cilium length. |
Kim et al. |
2010 |
20393563 |
Cell line |
htRPE |
Smoothed protein expression |
Fluorescence |
Human druggable genome siRNA library V3.1 |
Druggable genes |
siRNA |
Normalized percent inhibition |
> 1.5 OR < -1.5 standard deviations from mean |
|
GR00149-A-1 |
2521 |
2521 |
FUS |
121513 |
-17 |
none |
|
no |
|
Ciliogenesis and cilium length (1) |
Functional genomic screen for modulators of ciliogenesis and cilium length. |
Kim et al. |
2010 |
20393563 |
Cell line |
htRPE |
Smoothed protein expression |
Fluorescence |
Human druggable genome siRNA library V3.1 |
Druggable genes |
siRNA |
Normalized percent inhibition |
> 1.5 OR < -1.5 standard deviations from mean |
|
GR00149-A-1 |
2521 |
2521 |
FUS |
121514 |
11.18 |
none |
|
no |
|
Ciliogenesis and cilium length (1) |
Functional genomic screen for modulators of ciliogenesis and cilium length. |
Kim et al. |
2010 |
20393563 |
Cell line |
htRPE |
Smoothed protein expression |
Fluorescence |
Human druggable genome siRNA library V3.1 |
Druggable genes |
siRNA |
Normalized percent inhibition |
> 1.5 OR < -1.5 standard deviations from mean |
|
GR00149-A-1 |
2521 |
2521 |
FUS |
121514 |
-15.23 |
none |
|
no |
|
Ciliogenesis and cilium length (1) |
Functional genomic screen for modulators of ciliogenesis and cilium length. |
Kim et al. |
2010 |
20393563 |
Cell line |
htRPE |
Smoothed protein expression |
Fluorescence |
Human druggable genome siRNA library V3.1 |
Druggable genes |
siRNA |
Normalized percent inhibition |
> 1.5 OR < -1.5 standard deviations from mean |
|
GR00151-A-1 |
2521 |
ENSG00000089280 |
FUS |
np |
0.507 |
none |
|
no |
|
Homologous recombination DNA double-strand break repair (HR-DSBR) (1) |
A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. |
Słabicki et al. |
2010 |
20613862 |
Cell line |
HeLa |
(HR-DSBR) DR-GFP reporter |
Flow cytometry |
Custom-made |
Genome-wide |
esiRNA |
Z-score |
< -2 OR > 2 |
|
GR00180-A-1 |
2521 |
2521 |
FUS |
PL-50022 |
0.909 |
none |
|
no |
|
Hepatitis C virus replication (1) |
A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. |
Tai et al. |
2009 |
19286138 |
Cell line |
Huh7/Rep-Feo |
HCV replicon RNA copy number |
Luminescence |
siARRAY Human Genome siRNA Library |
Genome-wide |
siRNA |
q-value |
Complex criteria |
|
GR00184-A-1 |
2521 |
NM_004960 |
FUS |
M-009497-01 |
-1.97993480473208 |
none |
|
no |
|
Self-renewal and pluripotency in human embryonic stem cells (1) |
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. |
Chia et al. |
2010 |
20953172 |
Cell line |
hESC H1 |
POU5F1 protein expression |
Fluorescence |
SMARTpool siRNA library |
Genome-wide |
siRNA |
Z-score |
< -2 |
|
GR00197-A-1 |
2521 |
2521 |
FUS |
M-009497-01 |
1.459356171 |
none |
|
no |
|
Human papillomavirus oncogene expression regulation (1) |
Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. |
Smith et al. |
2010 |
20133580 |
Cell line |
C33A/BE2/18LCR c4 |
HPV18 LCR reporter activity |
Luminescence |
Human siGENOME SMARTpool library |
Genome-wide |
siRNA |
Z-score |
> |
Author-submitted data. Phenotype strength according to Z-scores: weak: 2 - 3; moderate: 3 - 5; strong: > 5 |
GR00221-A-1 |
2521 |
|
FUS |
TRCN0000039826 |
-0.16 |
none |
|
yes |
|
Proliferation of cells with active beta-catenin (1) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
MCF-7 |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-1 |
2521 |
|
FUS |
TRCN0000039824 |
0.65 |
none |
|
yes |
|
Proliferation of cells with active beta-catenin (1) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
MCF-7 |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-1 |
2521 |
|
FUS |
TRCN0000039823 |
0.75 |
none |
|
yes |
|
Proliferation of cells with active beta-catenin (1) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
MCF-7 |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-1 |
2521 |
|
FUS |
TRCN0000039825 |
2.35 |
none |
|
yes |
|
Proliferation of cells with active beta-catenin (1) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
MCF-7 |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-2 |
2521 |
|
FUS |
TRCN0000039826 |
-0.42 |
none |
|
yes |
|
Proliferation of cells with active beta-catenin (2) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
MDA-MB-231 |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-2 |
2521 |
|
FUS |
TRCN0000039827 |
0.05 |
none |
|
yes |
|
Proliferation of cells with active beta-catenin (2) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
MDA-MB-231 |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-2 |
2521 |
|
FUS |
TRCN0000039823 |
1.26 |
none |
|
yes |
|
Proliferation of cells with active beta-catenin (2) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
MDA-MB-231 |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-2 |
2521 |
|
FUS |
TRCN0000039825 |
1.33 |
none |
|
yes |
|
Proliferation of cells with active beta-catenin (2) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
MDA-MB-231 |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-2 |
2521 |
|
FUS |
TRCN0000039824 |
1.6 |
none |
|
yes |
|
Proliferation of cells with active beta-catenin (2) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
MDA-MB-231 |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-3 |
2521 |
|
FUS |
TRCN0000039826 |
-0.16 |
none |
|
yes |
|
Proliferation of cells with active beta-catenin (3) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
MDA-MB-453 |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-3 |
2521 |
|
FUS |
TRCN0000039823 |
0.22 |
none |
|
yes |
|
Proliferation of cells with active beta-catenin (3) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
MDA-MB-453 |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-3 |
2521 |
|
FUS |
TRCN0000039827 |
0.73 |
none |
|
yes |
|
Proliferation of cells with active beta-catenin (3) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
MDA-MB-453 |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-3 |
2521 |
|
FUS |
TRCN0000039824 |
1.43 |
none |
|
yes |
|
Proliferation of cells with active beta-catenin (3) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
MDA-MB-453 |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-3 |
2521 |
|
FUS |
TRCN0000039825 |
1.48 |
none |
|
yes |
|
Proliferation of cells with active beta-catenin (3) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
MDA-MB-453 |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-4 |
2521 |
|
FUS |
TRCN0000039826 |
-1.14 |
Decreased viability |
|
no |
|
Proliferation of cells with active beta-catenin (4) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
T47D |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-4 |
2521 |
|
FUS |
TRCN0000039823 |
-0.97 |
none |
|
no |
|
Proliferation of cells with active beta-catenin (4) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
T47D |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-4 |
2521 |
|
FUS |
TRCN0000039827 |
0.27 |
none |
|
no |
|
Proliferation of cells with active beta-catenin (4) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
T47D |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-4 |
2521 |
|
FUS |
TRCN0000039824 |
0.29 |
none |
|
no |
|
Proliferation of cells with active beta-catenin (4) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
T47D |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00221-A-4 |
2521 |
|
FUS |
TRCN0000039825 |
1.08 |
none |
|
no |
|
Proliferation of cells with active beta-catenin (4) |
CK1epsilon is required for breast cancers dependent on beta-catenin activity. |
Kim et al. |
2010 |
20126544 |
Cell line |
T47D |
Viability |
Luminescence |
TRC shRNA Library |
Kinases |
shRNA |
B-score |
< -1 |
Essential gene: gene with B-score < -1 for > |
GR00236-A-1 |
2521 |
2521 |
FUS |
M-009497-01 |
0.790821621920892 |
none |
|
no |
|
Homologous recombination DNA double-strand break repair (HR-DSBR) (1) |
A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. |
Adamson et al. |
2012 |
22344029 |
Cell line |
DR-U2OS |
(HR-DSBR) DR-GFP reporter and DNA content |
Fluorescence |
Human siGENOME siRNA (G-005000-05) |
Genome-wide |
siRNA |
Relative HR ratio |
< ~0.4 OR > 1.88 |
Cutoff values correspond 2 standard deviations from the screen-wide mean |
GR00240-S-1 |
2521 |
NM_004960 |
FUS |
M-009497-01 |
-1.04 |
none |
|
yes |
|
TRAIL-induced apoptosis (1) |
A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. |
Kranz and Boutros |
2014 |
24442637 |
Cell line |
U251MG |
Viability |
Luminescence |
SMART-pool siRNA |
Genome-wide |
siRNA |
Z-score |
> 4 |
Author-submitted data |
GR00240-S-2 |
2521 |
NM_004960 |
FUS |
M-009497-01 |
0.45 |
none |
|
no |
Z-score -0.5865 |
TRAIL-induced apoptosis (2) |
A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis. |
Kranz and Boutros |
2014 |
24442637 |
Cell line |
U251MG |
Viability (synthetic lethal) |
Luminescence |
SMART-pool siRNA |
Genome-wide |
siRNA |
Differential score |
> 3.6 AND viability Z-score < 4 |
Author-submitted data. Z-scores from viability screen (1) are considered in score interpretation for this screen. |
GR00242-A-1 |
2521 |
NM_004960 |
FUS |
np |
sp |
none |
|
no |
|
Selective autophagy regulation (1) |
Image-based genome-wide siRNA screen identifies selective autophagy factors. |
Orvedahl et al. |
2011 |
22020285 |
Cell line |
HeLa/GFP-LC3 |
Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression |
Fluorescence |
siGenome |
Genome-wide |
siRNA |
Z-score |
Complex criteria |
|
GR00247-A-1 |
2521 |
|
FUS |
np |
sp |
none |
|
|
rank: 12976 |
Regulation of FOXO1 nuclear localization (1) |
Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. |
Senapedis et al. |
2011 |
21460183 |
Cell line |
U2OS |
EGFP-FOXO1a protein expression and DNA content |
Fluorescence |
Human Genome library |
Genome-wide |
siRNA |
Complex, sp |
Complex criteria |
|
GR00249-S |
2521 |
2521 |
FUS |
J-009497-07 |
-1.51223 |
Decreased vaccinia virus (VACV) infection |
|
no |
number of cells compared to control (%): 84.42 |
Vaccinia virus (VACV) infection |
Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. |
Sivan et al. |
2013 |
23401514 |
Cell line |
HeLa |
Vaccinia virus VACV IHD-J/GFP protein expression and DNA content |
Fluorescence |
Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus |
Genome-wide |
siRNA |
Z-score |
> |
Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. |
GR00249-S |
2521 |
2521 |
FUS |
M-009497-02 |
0.0496 |
none |
|
no |
number of cells compared to control (%): 67.18 |
Vaccinia virus (VACV) infection |
Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. |
Sivan et al. |
2013 |
23401514 |
Cell line |
HeLa |
Vaccinia virus VACV IHD-J/GFP protein expression and DNA content |
Fluorescence |
Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus |
Genome-wide |
siRNA |
Z-score |
> |
Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. |
GR00249-S |
2521 |
2521 |
FUS |
s5401 |
-0.95234 |
none |
|
no |
number of cells compared to control (%): 62.09 |
Vaccinia virus (VACV) infection |
Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. |
Sivan et al. |
2013 |
23401514 |
Cell line |
HeLa |
Vaccinia virus VACV IHD-J/GFP protein expression and DNA content |
Fluorescence |
Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus |
Genome-wide |
siRNA |
Z-score |
> |
Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. |
GR00249-S |
2521 |
2521 |
FUS |
s5402 |
-1.63522 |
Decreased vaccinia virus (VACV) infection |
|
no |
number of cells compared to control (%): 89.28 |
Vaccinia virus (VACV) infection |
Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. |
Sivan et al. |
2013 |
23401514 |
Cell line |
HeLa |
Vaccinia virus VACV IHD-J/GFP protein expression and DNA content |
Fluorescence |
Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus |
Genome-wide |
siRNA |
Z-score |
> |
Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. |
GR00249-S |
2521 |
2521 |
FUS |
s5403 |
-0.90513 |
none |
|
no |
number of cells compared to control (%): 82.02 |
Vaccinia virus (VACV) infection |
Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. |
Sivan et al. |
2013 |
23401514 |
Cell line |
HeLa |
Vaccinia virus VACV IHD-J/GFP protein expression and DNA content |
Fluorescence |
Silencer Select Version 4, siGENOME SMARTpool and OnTargetPlus |
Genome-wide |
siRNA |
Z-score |
> |
Author-submitted data. Primary screen. Decreased viability phenotype if number of cells compared to control < 50 %. |
GR00253-A |
2521 |
NM_004960 |
FUS |
np |
-0.65 |
none |
|
|
|
hepcidin regulation |
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. |
Mleczko-Sanecka et al. |
2014 |
24385536 |
Cell line |
Huh7 |
hepcidin::fluc mRNA expression |
Luminescence |
siGenome siARRAY SMARTpool |
Genome-wide |
siRNA |
Z-score |
> |
Cutoff < |
GR00254-A |
2521 |
|
FUS |
np |
np |
none |
|
|
|
SMN2 splicing regulation |
Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation. |
Xiao et al. |
2012 |
22325991 |
Cell line |
HeLa |
SMN2-based splicing reporter expression |
Real-time PCR |
rp |
RNA-binding proteins |
esiRNA |
SMN2 FL/deltaexon 7 ratio |
np |
|
GR00255-A-1 |
2521 |
2521 |
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000001134, TRCN0000001135, TRCN0000010450, TRCN0000010451, TRCN0000010598, TRCN0000039823, TRCN0000039824, TRCN0000039825, TRCN0000039826, TRCN0000039827 |
-0.105707312 |
none |
|
|
|
Negative genetic interactions (1) |
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. |
Vizeacoumar et al. |
2013 |
24104479 |
Cell line |
HCT116 |
shRNA abundance |
Microarray |
np |
Genome-wide |
shRNA |
differential Gene Activity Ranking Profile (dGARP) |
< -1.0 |
HCT116 BLM-/- and HCT116 BLM+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) |
GR00255-A-2 |
2521 |
2521 |
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000001134, TRCN0000001135, TRCN0000010450, TRCN0000010451, TRCN0000010598, TRCN0000039823, TRCN0000039824, TRCN0000039825, TRCN0000039826, TRCN0000039827 |
0.057327747 |
none |
|
|
|
Negative genetic interactions (2) |
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. |
Vizeacoumar et al. |
2013 |
24104479 |
Cell line |
HCT116 |
shRNA abundance |
Microarray |
np |
Genome-wide |
shRNA |
differential Gene Activity Ranking Profile (dGARP) |
< -1.0 |
HCT116 MUS81-/- and HCT116 MUS81+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) |
GR00255-A-3 |
2521 |
2521 |
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000001134, TRCN0000001135, TRCN0000010450, TRCN0000010451, TRCN0000010598, TRCN0000039823, TRCN0000039824, TRCN0000039825, TRCN0000039826, TRCN0000039827 |
-1.839100421 |
Negative genetic interaction between PTEN-/- and PTEN+/+ |
|
|
|
Negative genetic interactions (3) |
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. |
Vizeacoumar et al. |
2013 |
24104479 |
Cell line |
HCT116 |
shRNA abundance |
Microarray |
np |
Genome-wide |
shRNA |
differential Gene Activity Ranking Profile (dGARP) |
< -1.2 |
HCT116 PTEN-/- and HCT116 PTEN+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) |
GR00255-A-4 |
2521 |
2521 |
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000001134, TRCN0000001135, TRCN0000010450, TRCN0000010451, TRCN0000010598, TRCN0000039823, TRCN0000039824, TRCN0000039825, TRCN0000039826, TRCN0000039827 |
0.135250786 |
none |
|
|
|
Negative genetic interactions (4) |
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. |
Vizeacoumar et al. |
2013 |
24104479 |
Cell line |
HCT116 |
shRNA abundance |
Microarray |
np |
Genome-wide |
shRNA |
differential Gene Activity Ranking Profile (dGARP) |
< -1.2 |
HCT116 PTTG1-/- and HCT116 PTTG1+/+ cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) |
GR00255-A-5 |
2521 |
2521 |
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000001134, TRCN0000001135, TRCN0000010450, TRCN0000010451, TRCN0000010598, TRCN0000039823, TRCN0000039824, TRCN0000039825, TRCN0000039826, TRCN0000039827 |
0.665021394 |
none |
|
|
|
Negative genetic interactions (5) |
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. |
Vizeacoumar et al. |
2013 |
24104479 |
Cell line |
HCT116 |
shRNA abundance |
Microarray |
np |
Genome-wide |
shRNA |
differential Gene Activity Ranking Profile (dGARP) |
< -0.8 |
HCT116 KRASG13D/- and HCT116 KRAS+/- cells used. Cutoff corresponds to p-value < 0.05. Additional information about a secondary screen (genetic interactions with Cetuximab/Erbitux in LIM1215 cells) |
GR00293-A |
2521 |
|
FUS |
np |
-1.634 |
none |
|
|
|
Combinatorial effect with paclitaxel |
Mechanisms Promoting Escape from Mitotic Stress−Induced Tumor Cell Death |
Sinnott et al. |
2014 |
24860162 |
Cell line |
HCC366 |
Viability |
Luminescence |
Thermo-Fisher |
Genome-wide |
siRNA |
Z-score |
< -2.5 |
Final hits according to the author are indicated in the comment. |
GR00300-A |
2521 |
|
FUS |
TRCN0000010450, TRCN0000001132, TRCN0000039824, TRCN0000001133, TRCN0000039825, TRCN0000010598, TRCN0000001134, TRCN0000039826, TRCN0000001135, TRCN0000039827 |
0 |
none |
|
|
|
Combinatorial effect with RAF inhibitor PLX4720 |
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. |
Whittaker et al. |
2013 |
23288408 |
Cell line |
A375 |
shRNA abundance |
Sequencing |
TRC |
Genome-wide |
shRNA |
Number of shRNAs ranked Top1000 |
> 2 |
The A375 cell line used here harbours the BRAF V600E mutation and is therefore sensitive to RAF inhibitors. |
GR00303-A |
2521 |
NM_004960 |
FUS |
np |
0 |
none |
|
|
|
Clear cell renal cell carcinoma (ccRCC) survival regulation |
Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target |
Gerlinger et al. |
2012 |
22362593 |
Cell line |
VHL-deficient RCC4 |
Proliferation and Viability |
Fluorescence |
np |
Genome-wide |
siRNA |
Z-score |
< |
In the phenotype data duplicates were in the original document, which have been removed. |
GR00310-A-1 |
2521 |
2521 |
FUS |
np |
1.4 |
none |
|
|
|
Sindbis virus (SINV) infection (1) |
Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry |
Ooi et al. |
2013 |
24367265 |
Cell line |
U2OS |
Sindbis virus (SINV) reporter |
Luminescence |
Ambion Silencer V3 |
Genome-wide |
siRNA |
Z-score |
< -3 OR > 2 |
|
|
2521 |
2521 |
FUS |
np |
-36.6 |
Increased NF-kappaB reporter expression |
|
|
90.8% viability; included in validation screen |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
GR00313-A |
2521 |
NM_001010850, NM_004960 |
FUS |
np |
-1.55 |
none |
|
|
|
TNF-alpha pathway regulation |
A Genome-Wide RNA Interference Screen Identifies Caspase 4 as a Factor Required for Tumor Necrosis Factor Alpha Signaling. |
Nickles et al. |
2012 |
22733992 |
Cell line |
HEK293T |
NFkappaB pathway reporter |
Luminescence |
Qiagen |
Genome-wide |
siRNA |
Z-score |
< |
Additional filters were a reduction in firefly luciferase levels by at least 50% compared to the mean of the experiment and a concomitant reduction of renilla luciferase expression of not more than 30%. |
GR00318-A |
2521 |
2521 |
FUS |
np |
0.943 |
none |
|
|
siRNA set: druggable genome |
Huntingtin toxicity |
A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease |
Miller et al. |
2012 |
23209424 |
Cell line |
HEK293T |
Caspase 3/7 activity |
Fluorescence |
Dharmacon |
Selected genes |
siRNA |
Sum of normalized caspase 3/7 activity mean and standard error |
< 0.683 |
HEK293T cells were cotransfected with mutant Huntingtin fused to GFP (Htt1-558141Q-GFP). |
GR00327-A |
2521 |
2521 |
MAP4K5 |
CLL-H-016369 |
0.09288268319766353 |
none |
|
|
|
Tumor formation |
An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation |
Wolf et al. |
2013 |
24292671 |
Cell line |
SUM-149 |
shRNA abundance |
Next-generation sequencing |
Decipher library module 1 |
Selected genes |
shRNA |
Z-score |
> 2.24 |
Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. |
GR00327-A |
2521 |
2521 |
MAP4K5 |
CLL-H-016372 |
-0.5288229535726552 |
none |
|
|
|
Tumor formation |
An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation |
Wolf et al. |
2013 |
24292671 |
Cell line |
SUM-149 |
shRNA abundance |
Next-generation sequencing |
Decipher library module 1 |
Selected genes |
shRNA |
Z-score |
> 2.24 |
Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. |
GR00327-A |
2521 |
2521 |
MAP4K5 |
CLL-H-016373 |
-0.031083050113991838 |
none |
|
|
|
Tumor formation |
An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation |
Wolf et al. |
2013 |
24292671 |
Cell line |
SUM-149 |
shRNA abundance |
Next-generation sequencing |
Decipher library module 1 |
Selected genes |
shRNA |
Z-score |
> 2.24 |
Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. |
GR00327-A |
2521 |
2521 |
MAP4K5 |
CLL-H-016371 |
0.3715399878790059 |
none |
|
|
|
Tumor formation |
An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation |
Wolf et al. |
2013 |
24292671 |
Cell line |
SUM-149 |
shRNA abundance |
Next-generation sequencing |
Decipher library module 1 |
Selected genes |
shRNA |
Z-score |
> 2.24 |
Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. |
GR00327-A |
2521 |
2521 |
MAP4K5 |
CLL-H-016370 |
1.2931309614810171 |
none |
|
|
|
Tumor formation |
An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation |
Wolf et al. |
2013 |
24292671 |
Cell line |
SUM-149 |
shRNA abundance |
Next-generation sequencing |
Decipher library module 1 |
Selected genes |
shRNA |
Z-score |
> 2.24 |
Genes were scored as hit if at least 2 shRNAs scored as hit, see comment. |
GR00343-S |
2521 |
2521 |
FUS |
TRCN0000039826 |
-1.2475000000000005 |
shRNA abundance <= 50% |
|
|
|
Lentiviral shRNA "Achilles Heel" screen |
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia |
Cole et al. |
2015 |
26058080 |
Cell line |
K562 |
shRNA abundance |
Fluorescence |
Lentiviral shRNA library |
Genome-wide |
shRNA |
Log2 ratio |
< |
Comparison of day 21 vs. day 0 abundance data |
GR00343-S |
2521 |
2521 |
FUS |
TRCN0000010450 |
-4.042499999999999 |
shRNA abundance <= 25% |
|
|
|
Lentiviral shRNA "Achilles Heel" screen |
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia |
Cole et al. |
2015 |
26058080 |
Cell line |
K562 |
shRNA abundance |
Fluorescence |
Lentiviral shRNA library |
Genome-wide |
shRNA |
Log2 ratio |
< |
Comparison of day 21 vs. day 0 abundance data |
GR00343-S |
2521 |
2521 |
FUS |
TRCN0000010451 |
0.8999999999999995 |
none |
|
|
|
Lentiviral shRNA "Achilles Heel" screen |
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia |
Cole et al. |
2015 |
26058080 |
Cell line |
K562 |
shRNA abundance |
Fluorescence |
Lentiviral shRNA library |
Genome-wide |
shRNA |
Log2 ratio |
< |
Comparison of day 21 vs. day 0 abundance data |
GR00343-S |
2521 |
2521 |
FUS |
TRCN0000039824 |
-1.6499999999999986 |
shRNA abundance <= 50% |
|
|
|
Lentiviral shRNA "Achilles Heel" screen |
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia |
Cole et al. |
2015 |
26058080 |
Cell line |
K562 |
shRNA abundance |
Fluorescence |
Lentiviral shRNA library |
Genome-wide |
shRNA |
Log2 ratio |
< |
Comparison of day 21 vs. day 0 abundance data |
GR00343-S |
2521 |
2521 |
FUS |
TRCN0000001133 |
-1.2324999999999982 |
shRNA abundance <= 50% |
|
|
|
Lentiviral shRNA "Achilles Heel" screen |
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia |
Cole et al. |
2015 |
26058080 |
Cell line |
K562 |
shRNA abundance |
Fluorescence |
Lentiviral shRNA library |
Genome-wide |
shRNA |
Log2 ratio |
< |
Comparison of day 21 vs. day 0 abundance data |
GR00343-S |
2521 |
2521 |
FUS |
TRCN0000039823 |
0.9425000000000008 |
none |
|
|
|
Lentiviral shRNA "Achilles Heel" screen |
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia |
Cole et al. |
2015 |
26058080 |
Cell line |
K562 |
shRNA abundance |
Fluorescence |
Lentiviral shRNA library |
Genome-wide |
shRNA |
Log2 ratio |
< |
Comparison of day 21 vs. day 0 abundance data |
GR00343-S |
2521 |
2521 |
FUS |
TRCN0000039825 |
-0.19500000000000206 |
none |
|
|
|
Lentiviral shRNA "Achilles Heel" screen |
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia |
Cole et al. |
2015 |
26058080 |
Cell line |
K562 |
shRNA abundance |
Fluorescence |
Lentiviral shRNA library |
Genome-wide |
shRNA |
Log2 ratio |
< |
Comparison of day 21 vs. day 0 abundance data |
GR00343-S |
2521 |
2521 |
FUS |
TRCN0000039827 |
0.8725000000000005 |
none |
|
|
|
Lentiviral shRNA "Achilles Heel" screen |
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia |
Cole et al. |
2015 |
26058080 |
Cell line |
K562 |
shRNA abundance |
Fluorescence |
Lentiviral shRNA library |
Genome-wide |
shRNA |
Log2 ratio |
< |
Comparison of day 21 vs. day 0 abundance data |
GR00343-S |
2521 |
2521 |
FUS |
TRCN0000001134 |
-0.5875000000000004 |
none |
|
|
|
Lentiviral shRNA "Achilles Heel" screen |
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia |
Cole et al. |
2015 |
26058080 |
Cell line |
K562 |
shRNA abundance |
Fluorescence |
Lentiviral shRNA library |
Genome-wide |
shRNA |
Log2 ratio |
< |
Comparison of day 21 vs. day 0 abundance data |
GR00343-S |
2521 |
2521 |
FUS |
TRCN0000001135 |
-0.3774999999999995 |
none |
|
|
|
Lentiviral shRNA "Achilles Heel" screen |
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia |
Cole et al. |
2015 |
26058080 |
Cell line |
K562 |
shRNA abundance |
Fluorescence |
Lentiviral shRNA library |
Genome-wide |
shRNA |
Log2 ratio |
< |
Comparison of day 21 vs. day 0 abundance data |
GR00343-S |
2521 |
2521 |
FUS |
TRCN0000001132 |
-3.1174999999999997 |
shRNA abundance <= 25% |
|
|
|
Lentiviral shRNA "Achilles Heel" screen |
Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leukemia |
Cole et al. |
2015 |
26058080 |
Cell line |
K562 |
shRNA abundance |
Fluorescence |
Lentiviral shRNA library |
Genome-wide |
shRNA |
Log2 ratio |
< |
Comparison of day 21 vs. day 0 abundance data |
|
2521 |
|
FUS |
np |
1 |
Resistant to vaccinia virus (VACV-A4L) infection |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
GR00363-A |
2521 |
2521 |
FUS |
SI00070497, SI00070518, SI03032225, 121513, SI00070504, 121512, esi1803 |
sp |
Decreased epidermal growth factor (EGF) endocytosis, increased transferrin (TF) endocytosis |
|
|
weak but specific |
Endocytosis regulation |
Systems survey of endocytosis by multiparametric image analysis. |
Collinet et al. |
2010 |
20190736 |
Cell line |
HeLa |
Transferrin (TF) and epidermal growth factor (EGF) subcellular localisation, DNA content |
Fluorescence |
Ambion, Qiagen and esiRNA library (Kittler et al.) |
Genome-wide |
siRNA |
Complex, sp |
Complex criteria |
Two hit categories: "strong" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn > 0.95) and "weak but specific" (maximum of Prob Chi2, Prob Chi2 EGF, Prob Chi2 Tfn < 0.95 but Phenoscore > 0.95). Additional information about secondary screens with kinase and phospatase libraries. |
GR00366-A-1 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.38287015052529 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (1) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
22RV1_PROSTATE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-10 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.462160723114946 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (10) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
ACHN_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-100 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.488576301432349 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (100) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-101 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.108670364962783 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (101) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LK2_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-102 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.64690408993254 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (102) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN215_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-103 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.22438139114226 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (103) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN229_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-104 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.353345724741989 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (104) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN235_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-105 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.782963067668329 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (105) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN319_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-106 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.967038871575993 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (106) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN340_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-107 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.946779508610285 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (107) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN382_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-108 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.12761945217459 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (108) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN428_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-109 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.751663993500533 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (109) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN443_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-11 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.467648077425728 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (11) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
AGS_STOMACH |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-110 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.142311838487961 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (110) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LN464_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-111 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.971524488156859 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (111) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LNZ308_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-112 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-2.1402563450353 |
Decreased shRNA abundance (Z-score < -2) |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (112) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LOVO_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-113 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.22590868213354 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (113) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LS411N_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-114 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.90718043537807 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (114) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
LS513_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-115 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
2.45958638837276 |
Increased shRNA abundance (Z-score > 2) |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (115) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MCF7_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-116 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.835338769301291 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (116) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MDAMB453_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-117 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.40128865324331 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (117) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MIAPACA2_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-118 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.91302155395624 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (118) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MKN7_STOMACH |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-119 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.206390383928267 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (119) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-12 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.542249442505384 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (12) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
AM38_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-120 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.03147553519356 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (120) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-121 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.625838922663762 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (121) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-122 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.0933311885418 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (122) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-123 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.0875628699547781 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (123) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-124 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.0103463615964187 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (124) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-125 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.194154007259047 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (125) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-126 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.30095338207543 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (126) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH1299_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-127 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.61335218463409 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (127) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH1437_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-128 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.72177731805042 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (128) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH1650_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-129 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.211968202282247 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (129) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH1792_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-13 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.460477214400238 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (13) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-130 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.590331593489594 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (130) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH196_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-131 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.225353123401846 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (131) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH1975_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-132 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.056849304595717 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (132) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH2052_PLEURA |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-133 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.1384680921336 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (133) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH2122_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-134 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.272360513277206 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (134) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH2171_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-135 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.858351405600763 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (135) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH23_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-136 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.0972144645605223 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (136) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH2452_PLEURA |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-137 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.28248919220285 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (137) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH441_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-138 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.891801853695003 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (138) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH508_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-139 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.65081393677951 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (139) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH660_PROSTATE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-14 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.69054321162719 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (14) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
ASPC1_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-140 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.741591398895462 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (140) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH661_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-141 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.474184465873702 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (141) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH716_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-142 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.629924397568002 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (142) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIH838_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-143 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.483400742365439 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (143) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NCIN87_STOMACH |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-144 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.21475587011634 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (144) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NIHOVCAR3_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-145 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.436611758541812 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (145) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-146 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.24002017561565 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (146) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OAW42_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-147 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.11738083162718 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (147) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-148 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.52515224872228 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (148) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-149 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.68137664337888 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (149) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-15 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.934330593150362 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (15) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
BT20_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-150 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.483606853729713 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (150) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OE33_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-151 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.51146095557032 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (151) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OELE_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-152 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.416338431072267 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (152) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-153 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.0532547452079822 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (153) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OV7_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-154 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.75898851118763 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (154) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OV90_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-155 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.376291225640668 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (155) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OVCAR4_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-156 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.228653368824513 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (156) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OVCAR8_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-157 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.982710880127787 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (157) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
OVISE_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-158 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.311674994186123 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (158) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
PANC0327_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-159 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.208664130701647 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (159) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
PANC0813_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-16 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
2.14769839173154 |
Increased shRNA abundance (Z-score > 2) |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (16) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
BT474_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-160 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.0138910608387206 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (160) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
PANC1005_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-161 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.45440113269061 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (161) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-162 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.553053274801299 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (162) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
PSN1_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-163 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.556247313212991 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (163) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
QGP1_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-164 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.576685726219297 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (164) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-165 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.919087614907347 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (165) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
RKN_SOFT_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-166 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.73997708803134 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (166) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
RKO_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-167 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.463238653583393 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (167) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
RMGI_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-168 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.04327344368552 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (168) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
RMUGS_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-169 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.519101385554183 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (169) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-17 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.01121517756524 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (17) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
BXPC3_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-170 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.77672414403355 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (170) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
RT112_URINARY_TRACT |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-171 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.0630035792560141 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (171) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-172 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.335449490125341 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (172) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SF126_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-173 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.451253550308476 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (173) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SF172_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-174 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.741031003719482 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (174) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SF295_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-175 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.242930559899376 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (175) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SF767_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-176 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.87486849432394 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (176) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SJSA1_BONE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-177 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.350965064393502 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (177) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SKCO1_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-178 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.933629368227123 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (178) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SKMEL5_SKIN |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-179 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.0207073384027975 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (179) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-18 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.536367713027592 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (18) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
C2BBE1_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-180 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.833418671826831 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (180) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-181 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.763287710930102 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (181) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SKOV3_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-182 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.378390425865364 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (182) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SKRC20_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-183 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.992567209180485 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (183) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SLR20_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-184 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.590785442326192 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (184) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SLR21_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-185 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.409713031804873 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (185) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SLR23_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-186 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.305545656791644 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (186) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SLR24_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-187 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.01650877139536 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (187) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SLR25_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-188 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.822415645483834 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (188) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SLR26_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-189 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.918749369788186 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (189) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SNU1105_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-19 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.575808264628322 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (19) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
C32_SKIN |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-190 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
2.56703539102358 |
Increased shRNA abundance (Z-score > 2) |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (190) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SNU840_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-191 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.964408571773609 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (191) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SNUC1_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-192 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.581099867316428 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (192) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SNUC2A_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-193 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.680791617224196 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (193) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SU8686_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-194 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.59782210972901 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (194) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SW1417_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-195 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.503968490369515 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (195) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SW1783_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-196 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.0580210657907178 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (196) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SW480_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-197 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.86656876458764 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (197) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
SW48_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-198 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.863140883012797 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (198) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
T98G_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-199 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.99831554556648 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (199) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TC71_BONE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-2 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.31051214764372 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (2) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-20 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.00326844185818188 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (20) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CADOES1_BONE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-200 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.923850439341322 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (200) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TCCSUP_URINARY_TRACT |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-201 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.309333466677024 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (201) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TE10_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-202 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.795792274787973 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (202) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TE15_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-203 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.276033999760447 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (203) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TE9_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-204 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.51484008536779 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (204) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-205 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.838339327406981 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (205) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TOV112D_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-206 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.489448133060477 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (206) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TOV21G_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-207 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.591248271837493 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (207) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TT_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-208 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.52287516286121 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (208) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
TYKNU_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-209 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.242251779207543 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (209) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
U178_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-21 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.235717490732969 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (21) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CAL120_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-210 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.60227524529529 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (210) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
U251MG_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-211 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.735705976527641 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (211) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
U343_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-212 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.241312543644157 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (212) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
U87MG_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-213 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.249535347327159 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (213) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
UOK101_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-214 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
2.88819268817351 |
Increased shRNA abundance (Z-score > 2) |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (214) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
VCAP_PROSTATE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-215 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.686031562346716 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (215) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
YKG1_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-216 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.170839325234615 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (216) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
ZR7530_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-22 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.230433739934022 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (22) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CAL51_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-23 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.744035512431511 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (23) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CALU1_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-24 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.790290942427839 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (24) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CAOV3_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-25 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.18447132641617 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (25) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CAOV4_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-26 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.661061811854852 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (26) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CAS1_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-27 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.03793348620215 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (27) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CFPAC1_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-28 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.0285532760388265 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (28) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CH157MN_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-29 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.619243089029361 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (29) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COLO205_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-3 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-2.0606874482647 |
Decreased shRNA abundance (Z-score < -2) |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (3) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
786O_KIDNEY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-30 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.0636890499069805 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (30) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COLO704_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-31 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.451443109967485 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (31) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COLO741_SKIN |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-32 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.243655812218788 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (32) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COLO783_SKIN |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-33 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.110902654648811 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (33) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
CORL23_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-34 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.94177399957862 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (34) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COV362_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-35 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.0523981130187908 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (35) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COV434_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-36 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.813360386045336 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (36) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COV504_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-37 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.977306543566614 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (37) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
COV644_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-38 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.42583817520184 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (38) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
DBTRG05MG_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-39 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
2.40406524492006 |
Increased shRNA abundance (Z-score > 2) |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (39) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
DKMG_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-4 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.524096910797168 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (4) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
A1207_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-40 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
2.10190210004599 |
Increased shRNA abundance (Z-score > 2) |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (40) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
DLD1_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-41 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.5374442828534 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (41) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
EFE184_ENDOMETRIUM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-42 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.261452742456442 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (42) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
EFM19_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-43 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.342917510199922 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (43) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
EFO21_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-44 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.215238908300889 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (44) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
EFO27_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-45 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.355989984783255 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (45) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
EW8_BONE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-46 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.250290053732068 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (46) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
EWS502_BONE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-47 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.564340223159941 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (47) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-48 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.70174944597145 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (48) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
GB1_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-49 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.681110249896569 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (49) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
GP2D_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-5 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.0689619259188088 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (5) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
A172_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-50 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.37238701298238 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (50) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC1187_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-51 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.233858338375864 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (51) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC1395_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-52 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.0492571618278224 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (52) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC1954_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-53 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.640346819262053 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (53) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC2218_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-54 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.52625543091344 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (54) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC2814_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-55 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.951163731120726 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (55) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC364_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-56 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.21994343978071 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (56) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC44_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-57 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-2.1885409075707 |
Decreased shRNA abundance (Z-score < -2) |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (57) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC70_BREAST |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-58 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.22779815625864 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (58) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC827GR5_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-59 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.326152236979562 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (59) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCC827_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-6 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.00574132231253498 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (6) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
A204_SOFT_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-60 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-2.31316440796005 |
Decreased shRNA abundance (Z-score < -2) |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (60) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HCT116_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-61 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.287009325756968 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (61) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HEC1A_ENDOMETRIUM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-62 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.421709027461246 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (62) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HEYA8_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-63 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.44005112594885 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (63) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-64 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.00438587781824 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (64) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HLF_LIVER |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-65 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.32204213659241 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (65) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-66 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.04832321034938 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (66) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HPAC_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-67 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.531341970689954 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (67) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HPAFII_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-68 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.936291712693517 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (68) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HS683_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-69 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.328137674294875 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (69) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HS766T_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-7 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.720317149818463 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (7) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
A2058_SKIN |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-70 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.34757237758393 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (70) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HS944T_SKIN |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-71 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.852573272372974 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (71) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HT1197_URINARY_TRACT |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-72 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.751996772834285 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (72) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HT29_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-73 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-2.32075166026299 |
Decreased shRNA abundance (Z-score < -2) |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (73) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HT55_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-74 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.01846850788321 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (74) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HUG1N_STOMACH |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-75 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.06864119189817 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (75) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
HUTU80_SMALL_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-76 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.393841341145575 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (76) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
IGR39_SKIN |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-77 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-2.00348062907309 |
Decreased shRNA abundance (Z-score < -2) |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (77) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
IGROV1_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-78 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
2.6041275420312 |
Increased shRNA abundance (Z-score > 2) |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (78) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
IOMMLEE_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-79 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.548035884659192 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (79) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
JHESOAD1_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-8 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.12944400899118 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (8) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
A549_LUNG |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-80 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.826468531389456 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (80) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
JHOC5_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-81 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.979088583705641 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (81) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
JHOM1_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-82 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.136062818550029 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (82) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-83 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.49498696748972 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (83) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-84 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.582021187105464 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (84) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KALS1_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-85 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.631276464769831 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (85) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-86 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.230921324062675 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (86) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KM12_LARGE_INTESTINE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-87 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.166638226279349 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (87) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-88 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.000368038472517779 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (88) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KNS60_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-89 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.695106658592657 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (89) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KNS81_CENTRAL_NERVOUS_SYSTEM |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-9 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.822127400832891 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (9) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
A673_BONE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-90 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.569258371991064 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (90) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KP1NL_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-91 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.38111012685008 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (91) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KP2_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-92 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.320656915963966 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (92) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KP4_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-93 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-1.2029839496371 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (93) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KURAMOCHI_OVARY |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-94 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.304472970905696 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (94) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KYSE150_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-95 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.919027169929186 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (95) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KYSE30_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-96 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
0.0743420302648563 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (96) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KYSE450_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-97 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.16890209284261 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (97) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
KYSE510_OESOPHAGUS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-98 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
1.30286067589249 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (98) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
L33_PANCREAS |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00366-A-99 |
2521 |
|
FUS |
TRCN0000001132, TRCN0000001133, TRCN0000010450, TRCN0000288639, TRCN0000288705 |
-0.359536906243705 |
none |
|
|
FUS_1_110111 |
Context-specific genetic dependencies (99) |
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies |
Cowley et al. |
2014 |
25984343 |
Cell line |
L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE |
shRNA abundance |
Next-generation sequencing |
TRC |
shRNA |
Genome-wide |
Fold change |
np (default cutoff applied: Z-score > 2 OR < -2) |
Detailed information and analysis options for this large-scale screening project can be found at http://www.broadinstitute.org/achilles. The authors didn't provide a score cutoff - therefore we applied a default cutoff for phenotype assignment. (Note: We didn't confirm normal distribution of the data, so the Z-score cutoff should be interpreted with caution.) |
GR00368-A |
2521 |
2521 |
FUS |
|
0.79 |
Decreased viability ratio |
|
|
wt viability: 0,81 |
Combinatorial effect with E-Cadherin |
Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin–Deficient Cells |
Telford et al. |
2015 |
25777964 |
Cell line |
MCF10A |
Viability (synthetic lethal) |
Luminescence |
Dharmacon |
Genome-wide |
siRNA |
CDH1(-/-)/wt viability ratio |
< |
MCF10A wild type viability higher-or-equal to 50% was considered as additional cutoff (values noted in "comment" section). |
|
2521 |
2521 |
FUS |
|
-0.11000000000000001 |
none |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
GR00371-A-1 |
2521 |
2521 |
FUS |
|
2.1490505428 |
Increased Nanog expression |
|
|
Ambion |
Nanog expression in absence of bFGF and TGFbeta |
Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways |
Gonzales et al. |
2015 |
26232226 |
Cell line |
NANOG-GFP H1 hESC |
NANOG expression |
Fluorescence |
Dharmacon and Ambion |
Selected genes |
siRNA |
Z-score |
>1,25 OR >1,5 [in at least two replicates] |
Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. |
GR00371-A-2 |
2521 |
FUS |
2521 |
|
0.515361437013 |
none |
|
|
Ambion |
Nanog expression in presence of TGFbeta inhibitor |
Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways |
Gonzales et al. |
2015 |
26232226 |
Cell line |
NANOG-GFP H1 hESC |
NANOG expression |
Fluorescence |
Dharmacon and Ambion |
Selected genes |
siRNA |
Z-score |
>1,25 OR >1,5 [in at least two replicates] |
Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. |
GR00371-A-3 |
2521 |
2521 |
FUS |
|
0.929146433905 |
none |
|
|
Ambion |
Nanog expression in presence of MEK inhibitor |
Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways |
Gonzales et al. |
2015 |
26232226 |
Cell line |
NANOG-GFP H1 hESC |
NANOG expression |
Fluorescence |
Dharmacon and Ambion |
Selected genes |
siRNA |
Z-score |
>1,25 OR >1,5 [in at least two replicates] |
Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. |
GR00371-A-4 |
2521 |
2521 |
FUS |
|
0.719104857288 |
none |
|
|
Ambion |
Nanog expression in presence of PI3K inhibitor |
Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways |
Gonzales et al. |
2015 |
26232226 |
Cell line |
NANOG-GFP H1 hESC |
NANOG expression |
Fluorescence |
Dharmacon and Ambion |
Selected genes |
siRNA |
Z-score |
>1,25 OR >1,5 [in at least two replicates] |
Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. |
GR00371-A-5 |
2521 |
2521 |
FUS |
|
-1.11409232307 |
none |
|
|
Ambion |
Nanog expression in presence of retinoic acid |
Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways |
Gonzales et al. |
2015 |
26232226 |
Cell line |
NANOG-GFP H1 hESC |
NANOG expression |
Fluorescence |
Dharmacon and Ambion |
Selected genes |
siRNA |
Z-score |
>1,25 OR >1,5 [in at least two replicates] |
Z-score shown is an average of the z-scores from the three replicates performed for each gene. In the "Comment" field, the siRNA library used for each particular gene is noted. |
GR00376-A-1 |
2521 |
2521 |
FUS |
|
0.166253103 |
none |
|
|
|
Mitigators of SS1P-induced immunotoxicity |
Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity |
Pasetto et al. |
2015 |
25713356 |
Cell line |
KB cells |
Viability |
Luminescence |
Ambion Silencer Select Version 4 |
Genome-wide |
siRNA |
RSA P-value |
<0.001 |
SS1P was applied in a "high dose", ≈EC90, 13 ng/ml. Cutoff was derived from data submitted to Pubchem (ID 1117281). Reagent sequences but no ID |
GR00376-A-2 |
2521 |
2521 |
FUS |
|
0.26491363 |
none |
|
|
|
Sensitizers of SS1P-induced immunotoxicity |
Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity |
Pasetto et al. |
2015 |
25713356 |
Cell line |
KB cells |
Viability |
Luminescence |
Ambion Silencer Select Version 4 |
Genome-wide |
siRNA |
RSA P-value |
<0.001 |
SS1P was applied in a "low dose", ≈EC30, 3 ng/ml. Cutoff was derived from data submitted to PubChem (ID 1117281). Reagent sequences but no ID |
GR00378-A |
2521 |
|
FUS |
|
-0.797986034 |
none |
|
|
|
Poliovirus vaccine production |
Engineering Enhanced Vaccine Cell Lines To Eradicate Vaccine-Preventable Diseases: the Polio End Game |
van der Sanden et al. |
2015 |
26581994 |
Cell line |
HEp-2C |
Infection with Attenuated Poliovirus |
ELISA |
Dharmacon |
Genome-wide |
siRNA |
Z-score |
> |
For infection, a single lot of the attenuated Sabin type 2 poliovirus was used for the screen. Gene IDs were not provided, only the gene name/symbol |
|
2521 |
NM_004960 |
FUS |
|
33.415 |
none |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
GR00386-A-1 |
2521 |
2521 |
FUS |
|
82.4323475722647 |
none |
|
|
|
NOD2 stimulation by MDP |
A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. |
Warner et al. |
2014 |
25170077 |
Cell line |
HEK293 stably expressing NOD2 |
Viability |
Luminescence |
Dharmacon |
Genome-wide |
siRNA |
Percentage growth |
Decreased: <70, increased: >120 |
Reagent IDs not provided |
GR00386-A-2 |
2521 |
2521 |
FUS |
|
-119.7 |
none |
|
|
|
MDP-induced IL-8 secretion |
A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. |
Warner et al. |
2014 |
25170077 |
Cell line |
HEK293 stably expressing NOD2 |
IL-8 secretion |
ELISA |
Dharmacon |
Genome-wide |
siRNA |
Percent inhibition of IL-8 secretion |
Increased: <-300, Decreased: >60 |
Concentration of IL-8 was measured from cell supernatants by sandwich ELISA. IL-8 values (pg/ml) were normalized to IL-8 secreted in cells treated with RIPK2-specific siRNA (100% inhibition) and non-targeting siRNA (0% inhibition). Secondary validating screen assessed 554 genes whose silencing affected MDP-induced IL-8 secretion in the primary screen. Final validated IL-8 regulators (positive or negative) are listed in the comments column. Reagent IDs not provided |