Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 65018
  • Symbol: PINK1
  • Description: PTEN induced kinase 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
65018 GO:0000287 IDA - magnesium ion binding 14607334 Function
65018 GO:0002020 IPI - protease binding 21138942 Function
65018 GO:0004672 IMP - protein kinase activity 25527497 Function
65018 GO:0004674 IDA - protein serine/threonine kinase activity 14607334,17579517,19880420,24784582,25527291 Function
65018 GO:0005515 IPI - protein binding 16632486,17579517,19229105,20153330,21177249,22078885,23933751..... Function
65018 GO:0005524 IDA - ATP binding 14607334 Function
65018 GO:0010857 IDA - calcium-dependent protein kinase activity 19880420 Function
65018 GO:0016301 IDA - kinase activity 15824318 Function
65018 GO:0031625 IPI - ubiquitin protein ligase binding 20798600 Function
65018 GO:0043422 IDA - protein kinase B binding 21177249 Function
65018 GO:0055131 IPI - C3HC4-type RING finger domain binding 19880420 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
65018 GO:0000422 IMP - mitophagy 20798600,23933751,24896179 Process
65018 GO:0001934 IDA - positive regulation of protein phosphorylation 25244949 Process
65018 GO:0002082 IDA - regulation of oxidative phosphorylation 20871098 Process
65018 GO:0006468 IDA - protein phosphorylation 14607334,21177249,25527291 Process
65018 GO:0006468 IMP - protein phosphorylation 25527497 Process
65018 GO:0006950 IDA - response to stress 15087508 Process
65018 GO:0006979 IGI - response to oxidative stress 24475098 Process
65018 GO:0007005 IMP - mitochondrion organization 18560593 Process
65018 GO:0010821 IMP - regulation of mitochondrion organization 21508222 Process
65018 GO:0016239 IMP - positive regulation of macroautophagy 20871098 Process
65018 GO:0016242 IMP - negative regulation of macroautophagy 19279012 Process
65018 GO:0016567 IMP - protein ubiquitination 23933751 Process
65018 GO:0018105 IDA - peptidyl-serine phosphorylation 17579517,19880420 Process
65018 GO:0031396 IDA - regulation of protein ubiquitination 19880420 Process
65018 GO:0031396 IMP - regulation of protein ubiquitination 20871098,23212910 Process
65018 GO:0033138 IDA - positive regulation of peptidyl-serine phosphorylation 21177249 Process
65018 GO:0033138 IMP - positive regulation of peptidyl-serine phosphorylation 24660806 Process
65018 GO:0034599 IMP - cellular response to oxidative stress 22764206 Process
65018 GO:0035556 IDA - intracellular signal transduction 14607334 Process
65018 GO:0036289 IMP - peptidyl-serine autophosphorylation 25527497 Process
65018 GO:0043123 IDA - positive regulation of I-kappaB kinase/NF-kappaB signaling 19880420 Process
65018 GO:0043254 IDA - regulation of protein complex assembly 19880420 Process
65018 GO:0043524 IMP - negative regulation of neuron apoptotic process 18560593 Process
65018 GO:0050821 IMP - protein stabilization 19229105 Process
65018 GO:0051881 IGI - regulation of mitochondrial membrane potential 24475098 Process
65018 GO:0051881 IMP - regulation of mitochondrial membrane potential 18560593,21138942 Process
65018 GO:0071456 IMP - cellular response to hypoxia 24553947 Process
65018 GO:0072655 IMP - establishment of protein localization to mitochondrion 25527497 Process
65018 GO:0072656 IMP - maintenance of protein location in mitochondrion 25527497 Process
65018 GO:0090200 IMP - positive regulation of release of cytochrome c from mitochondria 19880420 Process
65018 GO:0090258 IMP - negative regulation of mitochondrial fission 19279012 Process
65018 GO:0098779 IMP - mitophagy in response to mitochondrial depolarization 20871098 Process
65018 GO:0099074 IMP - mitochondrion to lysosome transport 24446486 Process
65018 GO:1900407 IMP - regulation of cellular response to oxidative stress 24446486 Process
65018 GO:1902902 IMP - negative regulation of autophagosome assembly 19279012 Process
65018 GO:1903147 IMP - negative regulation of mitophagy 19279012 Process
65018 GO:1903202 IDA - negative regulation of oxidative stress-induced cell death 16632486 Process
65018 GO:1903214 IDA - regulation of protein targeting to mitochondrion 25244949 Process
65018 GO:1903214 IGI - regulation of protein targeting to mitochondrion 21508222 Process
65018 GO:1903214 IMP - regulation of protein targeting to mitochondrion 23212910 Process
65018 GO:1903384 IDA - negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway 21177249 Process
65018 GO:1903384 IMP - negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway 23261939 Process
65018 GO:1903751 IDA - negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide 17579517 Process
65018 GO:1903852 IMP - positive regulation of cristae formation 19279012 Process
65018 GO:1903955 IMP - positive regulation of protein targeting to mitochondrion 24270810 Process
65018 GO:2000377 IGI - regulation of reactive oxygen species metabolic process 24475098 Process
65018 GO:2000377 IMP - regulation of reactive oxygen species metabolic process 21138942 Process
65018 GO:2000378 IMP - negative regulation of reactive oxygen species metabolic process 18560593 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
65018 GO:0000785 IDA - chromatin 24798695 Component
65018 GO:0005634 IDA - nucleus 24798695 Component
65018 GO:0005737 IDA - cytoplasm 16702191 Component
65018 GO:0005739 IDA - mitochondrion 15087508,15824318,16702191,19229105,20798600,21138942,23933751..... Component
65018 GO:0005739 IGI colocalizes_with mitochondrion 21355049 Component
65018 GO:0005739 IMP colocalizes_with mitochondrion 24184327 Component
65018 GO:0005741 IDA - mitochondrial outer membrane 21426348 Component
65018 GO:0005741 IMP colocalizes_with mitochondrial outer membrane 25527497 Component
65018 GO:0005742 IMP colocalizes_with mitochondrial outer membrane translocase complex 24270810 Component
65018 GO:0005743 IDA - mitochondrial inner membrane 17579517,21426348 Component
65018 GO:0005758 IDA - mitochondrial intermembrane space 17579517,21426348 Component
65018 GO:0005829 IDA - cytosol 19229105,19880420,20798600,21138942,21426348,24798695..... Component
65018 GO:0005856 IDA - cytoskeleton 24798695 Component
65018 GO:0016020 IDA - membrane 24798695 Component
65018 GO:0030424 IDA - axon 16702191 Component
65018 GO:0031307 IDA - integral component of mitochondrial outer membrane 18687899 Component
65018 GO:0031932 IPI colocalizes_with TORC2 complex 21177249 Component
65018 GO:0044297 IDA - cell body 16702191 Component
65018 GO:0048471 IDA - perinuclear region of cytoplasm 16702191 Component
65018 GO:0097449 IDA - astrocyte projection 16702191 Component