Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:176
• Symbol:ACAN
• Description:aggrecan

DataSource: http://genomecrispr.dkfz.de/#!/results/ACAN

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
88855141	88855164	15	+	26472758	Jiyoye	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	-1.8345823646975057	[174]	[36]	-8	hSpCas9	negative selection	1327
88849598	88849621	15	-	26472758	Jiyoye	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	0.4071753815058732	[10]	[10]	3	hSpCas9	negative selection	1328
88838735	88838758	15	-	26472758	Jiyoye	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	1.0165909259515684	[77]	[118]	6	hSpCas9	negative selection	1329
88838774	88838797	15	-	26472758	Jiyoye	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	0.40717538150587274	[0]	[0]	3	hSpCas9	negative selection	1330
88838789	88838812	15	-	26472758	Jiyoye	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	0.19957996209750592	[96]	[83]	1	hSpCas9	negative selection	1331
88838835	88838858	15	+	26472758	Jiyoye	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	3.4839909785567045	[15]	[134]	9	hSpCas9	negative selection	1332
88840105	88840128	15	-	26472758	Jiyoye	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	0.10614251092986082	[376]	[305]	0	hSpCas9	negative selection	1333
88843474	88843497	15	+	26472758	Jiyoye	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	0.6702097873396672	[69]	[83]	5	hSpCas9	negative selection	1334
88843526	88843549	15	-	26472758	Jiyoye	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	1.9921378822270288	[0]	[2]	8	hSpCas9	negative selection	1335
88847946	88847969	15	+	26472758	Jiyoye	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	0.36025433411838104	[249]	[241]	2	hSpCas9	negative selection	1336
88855141	88855164	15	+	26472758	KBM7	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	-0.528789880167517	[321,219]	[104,70]	-5	hSpCas9	negative selection	192445
88849598	88849621	15	-	26472758	KBM7	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	0.26680507715939306	[143,146]	[29,129]	2	hSpCas9	negative selection	192446
88838735	88838758	15	-	26472758	KBM7	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	0.11390160611972316	[367,467]	[332,111]	1	hSpCas9	negative selection	192447
88838774	88838797	15	-	26472758	KBM7	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	1.4496714377812348	[17,30]	[32,31]	9	hSpCas9	negative selection	192448
88838789	88838812	15	-	26472758	KBM7	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	0.27178725864454645	[475,260]	[166,236]	3	hSpCas9	negative selection	192449
88838835	88838858	15	+	26472758	KBM7	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	-0.32255041830597275	[614,387]	[267,110]	-3	hSpCas9	negative selection	192450
88840105	88840128	15	-	26472758	KBM7	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	-0.1876626050837673	[1178,964]	[360,510]	-2	hSpCas9	negative selection	192451
88843474	88843497	15	+	26472758	KBM7	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	-0.39340053059378977	[603,582]	[78,332]	-4	hSpCas9	negative selection	192452
88843526	88843549	15	-	26472758	KBM7	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	0.16735806652855878	[36,8]	[2,18]	1	hSpCas9	negative selection	192453
88847946	88847969	15	+	26472758	KBM7	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	-0.22166432263281965	[1388,1090]	[490,500]	-2	hSpCas9	negative selection	192454
88855141	88855164	15	+	26472758	Raji	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	-0.8526183966944816	[248]	[31]	-6	hSpCas9	negative selection	383563
88849598	88849621	15	-	26472758	Raji	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	0.48847370272910573	[42]	[13]	4	hSpCas9	negative selection	383564
88838735	88838758	15	-	26472758	Raji	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	0.08058347602988425	[162]	[39]	0	hSpCas9	negative selection	383565
88838774	88838797	15	-	26472758	Raji	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	1.1073835353735992	[3]	[1]	8	hSpCas9	negative selection	383566
88838789	88838812	15	-	26472758	Raji	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	-1.1041205698201122	[175]	[18]	-7	hSpCas9	negative selection	383567
88838835	88838858	15	+	26472758	Raji	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	0.23291441745745842	[197]	[53]	2	hSpCas9	negative selection	383568
88840105	88840128	15	-	26472758	Raji	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	-0.11578348734569244	[620]	[132]	-1	hSpCas9	negative selection	383569
88843474	88843497	15	+	26472758	Raji	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	-0.25863714369693347	[298]	[57]	-2	hSpCas9	negative selection	383570
88843526	88843549	15	-	26472758	Raji	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	3.1073835353735992	[0]	[1]	9	hSpCas9	negative selection	383571
88847946	88847969	15	+	26472758	Raji	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	0.3871612050419697	[513]	[155]	3	hSpCas9	negative selection	383572
88855141	88855164	15	+	26472758	K562	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	-0.8106226358915151	[373]	[179]	-5	hSpCas9	negative selection	574681
88849598	88849621	15	-	26472758	K562	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	0.5750640396549181	[131]	[165]	4	hSpCas9	negative selection	574682
88838735	88838758	15	-	26472758	K562	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	-0.21416648728515375	[638]	[464]	-1	hSpCas9	negative selection	574683
88838774	88838797	15	-	26472758	K562	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	-3.7097775827204287	[30]	[1]	-9	hSpCas9	negative selection	574684
88838789	88838812	15	-	26472758	K562	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	-0.40104851201426317	[279]	[178]	-3	hSpCas9	negative selection	574685
88838835	88838858	15	+	26472758	K562	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	0.12118696167217605	[341]	[313]	0	hSpCas9	negative selection	574686
88840105	88840128	15	-	26472758	K562	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	0.3084167259546762	[947]	[990]	2	hSpCas9	negative selection	574687
88843474	88843497	15	+	26472758	K562	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	0.7218013411877885	[333]	[464]	6	hSpCas9	negative selection	574688
88843526	88843549	15	-	26472758	K562	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	-4.147898695112312	[20]	[0]	-9	hSpCas9	negative selection	574689
88847946	88847969	15	+	26472758	K562	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	0.13711224904494923	[850]	[789]	1	hSpCas9	negative selection	574690
88838817	88838840	15	+	26627737	DLD1	viability	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	0.8137267343212495	[327]	[169,224,151]	7	hSpCas9	negative selection	792219
88840078	88840101	15	-	26627737	DLD1	viability	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	0.3061005614344601	[104]	[103,21,0]	3	hSpCas9	negative selection	792220
88841756	88841779	15	-	26627737	DLD1	viability	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.9865156476877409	[952]	[120,73,238]	-7	hSpCas9	negative selection	792221
88843539	88843562	15	-	26627737	DLD1	viability	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-0.11099519481801523	[208]	[70,66,45]	-1	hSpCas9	negative selection	792222
88845859	88845882	15	+	26627737	DLD1	viability	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	-0.18386581426400916	[713]	[196,239,159]	-2	hSpCas9	negative selection	792223
88847352	88847375	15	-	26627737	DLD1	viability	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	0.3692633124078425	[191]	[145,55,35]	4	hSpCas9	negative selection	792224
88838817	88838840	15	+	26627737	GBM cells	viability after 5 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	0.20653843174355002	[222]	[116,158]	3	hSpCas9	negative selection	874534
88840078	88840101	15	-	26627737	GBM cells	viability after 5 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	0.4173809638199346	[36]	[20,31]	6	hSpCas9	negative selection	874535
88841756	88841779	15	-	26627737	GBM cells	viability after 5 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.2324840142301695	[447]	[180,227]	-4	hSpCas9	negative selection	874536
88843539	88843562	15	-	26627737	GBM cells	viability after 5 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	0.9908363643267248	[75]	[61,99]	9	hSpCas9	negative selection	874537
88845859	88845882	15	+	26627737	GBM cells	viability after 5 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	-0.06501687040679249	[315]	[129,193]	-1	hSpCas9	negative selection	874538
88847352	88847375	15	-	26627737	GBM cells	viability after 5 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	0.8930373085490162	[122]	[152,91]	9	hSpCas9	negative selection	874539
88838817	88838840	15	+	26627737	GBM cells	viability after 13 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	0.22376081811343734	[222]	[180,108]	3	hSpCas9	negative selection	956849
88840078	88840101	15	-	26627737	GBM cells	viability after 13 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	1.5164784619803222	[36]	[100,21]	9	hSpCas9	negative selection	956850
88841756	88841779	15	-	26627737	GBM cells	viability after 13 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	0.059962306562976964	[447]	[275,234]	0	hSpCas9	negative selection	956851
88843539	88843562	15	-	26627737	GBM cells	viability after 13 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	0.44757957686527106	[75]	[42,66]	5	hSpCas9	negative selection	956852
88845859	88845882	15	+	26627737	GBM cells	viability after 13 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	-0.3593139749008967	[315]	[131,134]	-4	hSpCas9	negative selection	956853
88847352	88847375	15	-	26627737	GBM cells	viability after 13 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	0.6174118757125506	[122]	[108,96]	7	hSpCas9	negative selection	956854
88838817	88838840	15	+	26627737	GBM cells	viability after 21 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	0.7121670770171745	[222]	[198,197]	7	hSpCas9	negative selection	1039164
88840078	88840101	15	-	26627737	GBM cells	viability after 21 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	1.4068435618585218	[36]	[57,48]	9	hSpCas9	negative selection	1039165
88841756	88841779	15	-	26627737	GBM cells	viability after 21 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.08044723573822254	[447]	[260,201]	0	hSpCas9	negative selection	1039166
88843539	88843562	15	-	26627737	GBM cells	viability after 21 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-0.33109319939281256	[75]	[36,28]	-3	hSpCas9	negative selection	1039167
88845859	88845882	15	+	26627737	GBM cells	viability after 21 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	-0.5350747726273861	[315]	[118,117]	-5	hSpCas9	negative selection	1039168
88847352	88847375	15	-	26627737	GBM cells	viability after 21 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	1.1901739826224056	[122]	[152,151]	9	hSpCas9	negative selection	1039169
88838817	88838840	15	+	26627737	RPE1	viability after 9 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	1.0936782045803548	[501]	[289,393]	6	hSpCas9	negative selection	1121479
88840078	88840101	15	-	26627737	RPE1	viability after 9 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	-0.7350416221582421	[219]	[12,77]	-5	hSpCas9	negative selection	1121480
88841756	88841779	15	-	26627737	RPE1	viability after 9 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.7697713844137826	[1923]	[275,452]	-5	hSpCas9	negative selection	1121481
88843539	88843562	15	-	26627737	RPE1	viability after 9 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	0.5981654895298043	[218]	[60,158]	4	hSpCas9	negative selection	1121482
88845859	88845882	15	+	26627737	RPE1	viability after 9 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	1.86198279867457	[419]	[432,535]	8	hSpCas9	negative selection	1121483
88847352	88847375	15	-	26627737	RPE1	viability after 9 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	0.5119005612020848	[498]	[103,375]	3	hSpCas9	negative selection	1121484
88838817	88838840	15	+	26627737	RPE1	viability after 12 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	-0.11924270004131787	[501]	[95,153]	-1	hSpCas9	negative selection	1203794
88840078	88840101	15	-	26627737	RPE1	viability after 12 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	-1.5757394662182271	[219]	[13,25]	-8	hSpCas9	negative selection	1203795
88841756	88841779	15	-	26627737	RPE1	viability after 12 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.41376259707287477	[1923]	[524,242]	-3	hSpCas9	negative selection	1203796
88843539	88843562	15	-	26627737	RPE1	viability after 12 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	0.5618969434579459	[218]	[81,91]	4	hSpCas9	negative selection	1203797
88845859	88845882	15	+	26627737	RPE1	viability after 12 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	1.5037939888943774	[419]	[336,301]	8	hSpCas9	negative selection	1203798
88847352	88847375	15	-	26627737	RPE1	viability after 12 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	0.21650223619612013	[498]	[96,217]	1	hSpCas9	negative selection	1203799
88838817	88838840	15	+	26627737	RPE1	viability after 15 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	-0.38649968231620935	[501]	[44,169]	-2	hSpCas9	negative selection	1286109
88840078	88840101	15	-	26627737	RPE1	viability after 15 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	-2.077521119427799	[219]	[0,27]	-8	hSpCas9	negative selection	1286110
88841756	88841779	15	-	26627737	RPE1	viability after 15 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.09272875884168563	[1923]	[657,367]	0	hSpCas9	negative selection	1286111
88843539	88843562	15	-	26627737	RPE1	viability after 15 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	0.567682700010429	[218]	[101,81]	3	hSpCas9	negative selection	1286112
88845859	88845882	15	+	26627737	RPE1	viability after 15 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	1.427287848911617	[419]	[289,347]	7	hSpCas9	negative selection	1286113
88847352	88847375	15	-	26627737	RPE1	viability after 15 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	-0.48374379975638715	[498]	[75,124]	-3	hSpCas9	negative selection	1286114
88838817	88838840	15	+	26627737	RPE1	viability after 18 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	0.6264649520018715	[501]	[154,266]	4	hSpCas9	negative selection	1368424
88840078	88840101	15	-	26627737	RPE1	viability after 18 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	-0.8514471860304531	[219]	[0,66]	-5	hSpCas9	negative selection	1368425
88841756	88841779	15	-	26627737	RPE1	viability after 18 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.25194640906260957	[1923]	[567,294]	-1	hSpCas9	negative selection	1368426
88843539	88843562	15	-	26627737	RPE1	viability after 18 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	0.5612001576241217	[218]	[63,111]	3	hSpCas9	negative selection	1368427
88845859	88845882	15	+	26627737	RPE1	viability after 18 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	1.9649177574117815	[419]	[514,364]	8	hSpCas9	negative selection	1368428
88847352	88847375	15	-	26627737	RPE1	viability after 18 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	-0.7231998089953935	[498]	[39,125]	-4	hSpCas9	negative selection	1368429
88838817	88838840	15	+	26627737	HeLa	viability after 8 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	-0.16313897932404614	[282]	[112,83,131]	-1	hSpCas9	negative selection	1450739
88840078	88840101	15	-	26627737	HeLa	viability after 8 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	-0.4373396840536845	[71]	[6,22,34]	-4	hSpCas9	negative selection	1450740
88841756	88841779	15	-	26627737	HeLa	viability after 8 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.37784033641144366	[599]	[222,203,181]	-4	hSpCas9	negative selection	1450741
88843539	88843562	15	-	26627737	HeLa	viability after 8 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-0.21746963531611818	[219]	[110,84,58]	-2	hSpCas9	negative selection	1450742
88845859	88845882	15	+	26627737	HeLa	viability after 8 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	0.8337406919243571	[331]	[363,353,89]	6	hSpCas9	negative selection	1450743
88847352	88847375	15	-	26627737	HeLa	viability after 8 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	0.4439196207564555	[95]	[75,1,93]	4	hSpCas9	negative selection	1450744
88838817	88838840	15	+	26627737	HeLa	viability after 12 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	-0.49343752603221575	[282]	[4,110,127]	-4	hSpCas9	negative selection	1533054
88840078	88840101	15	-	26627737	HeLa	viability after 12 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	0.026960576944619064	[71]	[11,71,1]	0	hSpCas9	negative selection	1533055
88841756	88841779	15	-	26627737	HeLa	viability after 12 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.09313920143973531	[599]	[348,182,173]	-1	hSpCas9	negative selection	1533056
88843539	88843562	15	-	26627737	HeLa	viability after 12 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-0.24980548142939563	[219]	[5,107,109]	-2	hSpCas9	negative selection	1533057
88845859	88845882	15	+	26627737	HeLa	viability after 12 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	0.662735759892138	[331]	[225,215,209]	5	hSpCas9	negative selection	1533058
88847352	88847375	15	-	26627737	HeLa	viability after 12 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	0.8395598508900575	[95]	[80,16,120]	6	hSpCas9	negative selection	1533059
88838817	88838840	15	+	26627737	HeLa	viability after 15 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	-0.5456300779888139	[282]	[98,64,71]	-5	hSpCas9	negative selection	1615369
88840078	88840101	15	-	26627737	HeLa	viability after 15 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	0.23061952192856872	[71]	[1,13,91]	2	hSpCas9	negative selection	1615370
88841756	88841779	15	-	26627737	HeLa	viability after 15 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.5219933591955301	[599]	[133,191,185]	-4	hSpCas9	negative selection	1615371
88843539	88843562	15	-	26627737	HeLa	viability after 15 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	0.2360618161639947	[219]	[119,93,101]	2	hSpCas9	negative selection	1615372
88845859	88845882	15	+	26627737	HeLa	viability after 15 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	1.4084094540903502	[331]	[354,221,510]	8	hSpCas9	negative selection	1615373
88847352	88847375	15	-	26627737	HeLa	viability after 15 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	2.059968142196804	[95]	[200,92,196]	9	hSpCas9	negative selection	1615374
88838817	88838840	15	+	26627737	HeLa	viability after 18 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	-0.41872527954862754	[282]	[77,56,71]	-4	hSpCas9	negative selection	1697684
88840078	88840101	15	-	26627737	HeLa	viability after 18 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	0.25168926654695856	[71]	[1,11,91]	2	hSpCas9	negative selection	1697685
88841756	88841779	15	-	26627737	HeLa	viability after 18 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.5111097051677332	[599]	[93,156,185]	-4	hSpCas9	negative selection	1697686
88843539	88843562	15	-	26627737	HeLa	viability after 18 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	0.2206258042546445	[219]	[78,76,101]	1	hSpCas9	negative selection	1697687
88845859	88845882	15	+	26627737	HeLa	viability after 18 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	1.4324962874068683	[331]	[248,184,510]	8	hSpCas9	negative selection	1697688
88847352	88847375	15	-	26627737	HeLa	viability after 18 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	2.0651036949048165	[95]	[131,81,196]	9	hSpCas9	negative selection	1697689
88838817	88838840	15	+	26627737	HCT116	viability after 6 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	-1.688942191872926	[735]	[51,26]	-7	hSpCas9	negative selection	1779999
88840078	88840101	15	-	26627737	HCT116	viability after 6 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	3.4478408899471864	[47]	[33,108]	9	hSpCas9	negative selection	1780000
88841756	88841779	15	-	26627737	HCT116	viability after 6 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	0.3399256286193477	[1304]	[142,323]	2	hSpCas9	negative selection	1780001
88843539	88843562	15	-	26627737	HCT116	viability after 6 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-0.18718313872192693	[289]	[50,33]	-1	hSpCas9	negative selection	1780002
88845859	88845882	15	+	26627737	HCT116	viability after 6 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	0.8463635626383086	[990]	[292,272]	4	hSpCas9	negative selection	1780003
88847352	88847375	15	-	26627737	HCT116	viability after 6 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	2.1345784443289166	[240]	[108,197]	9	hSpCas9	negative selection	1780004
88838817	88838840	15	+	26627737	HCT116	viability after 8 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	0.021071211126365008	[256]	[112,128,187]	0	hSpCas9	negative selection	1862314
88840078	88840101	15	-	26627737	HCT116	viability after 8 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	-0.9386122106090184	[95]	[30,35,15]	-8	hSpCas9	negative selection	1862315
88841756	88841779	15	-	26627737	HCT116	viability after 8 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.8508026063521578	[599]	[165,146,235]	-8	hSpCas9	negative selection	1862316
88843539	88843562	15	-	26627737	HCT116	viability after 8 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	0.3030690676360466	[120]	[37,43,162]	3	hSpCas9	negative selection	1862317
88845859	88845882	15	+	26627737	HCT116	viability after 8 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	-0.12426373792412237	[552]	[257,273,305]	-1	hSpCas9	negative selection	1862318
88847352	88847375	15	-	26627737	HCT116	viability after 8 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	0.705429782584003	[91]	[70,111,64]	6	hSpCas9	negative selection	1862319
88838817	88838840	15	+	26627737	HCT116	viability after 9 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	-0.4282135510068095	[735]	[135,153]	-3	hSpCas9	negative selection	1944629
88840078	88840101	15	-	26627737	HCT116	viability after 9 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	0.892480030449299	[47]	[20,25]	6	hSpCas9	negative selection	1944630
88841756	88841779	15	-	26627737	HCT116	viability after 9 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.6187539184995261	[1304]	[384,101]	-4	hSpCas9	negative selection	1944631
88843539	88843562	15	-	26627737	HCT116	viability after 9 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-0.350160262683493	[289]	[24,88]	-2	hSpCas9	negative selection	1944632
88845859	88845882	15	+	26627737	HCT116	viability after 9 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	0.8069765814994649	[990]	[367,537]	6	hSpCas9	negative selection	1944633
88847352	88847375	15	-	26627737	HCT116	viability after 9 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	-0.12195586771288602	[240]	[95,29]	-1	hSpCas9	negative selection	1944634
88838817	88838840	15	+	26627737	HCT116	viability after 12 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	-0.23471117508806658	[256]	[95,114,134]	-2	hSpCas9	negative selection	2026944
88840078	88840101	15	-	26627737	HCT116	viability after 12 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	-0.5418094172782684	[95]	[25,45,32]	-5	hSpCas9	negative selection	2026945
88841756	88841779	15	-	26627737	HCT116	viability after 12 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.6045881456998097	[599]	[105,247,277]	-6	hSpCas9	negative selection	2026946
88843539	88843562	15	-	26627737	HCT116	viability after 12 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-0.7405952055331746	[120]	[39,37,35]	-7	hSpCas9	negative selection	2026947
88845859	88845882	15	+	26627737	HCT116	viability after 12 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	-0.3581450000551545	[552]	[293,173,204]	-4	hSpCas9	negative selection	2026948
88847352	88847375	15	-	26627737	HCT116	viability after 12 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	1.4451480351286046	[91]	[26,125,250]	9	hSpCas9	negative selection	2026949
88838817	88838840	15	+	26627737	HCT116	viability after 15 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	-0.46118615428622645	[256]	[53,140,119]	-5	hSpCas9	negative selection	2109259
88840078	88840101	15	-	26627737	HCT116	viability after 15 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	0.5913587229559663	[95]	[64,181,0]	5	hSpCas9	negative selection	2109260
88841756	88841779	15	-	26627737	HCT116	viability after 15 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.9581012214246337	[599]	[110,150,260]	-7	hSpCas9	negative selection	2109261
88843539	88843562	15	-	26627737	HCT116	viability after 15 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-0.861636020326616	[120]	[8,49,51]	-7	hSpCas9	negative selection	2109262
88845859	88845882	15	+	26627737	HCT116	viability after 15 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	-0.05724665596124212	[552]	[421,210,296]	0	hSpCas9	negative selection	2109263
88847352	88847375	15	-	26627737	HCT116	viability after 15 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	0.5129727521910465	[91]	[104,66,57]	5	hSpCas9	negative selection	2109264
88838817	88838840	15	+	26627737	HCT116	viability after 18 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	0.11371740022155191	[256]	[76,134,193]	1	hSpCas9	negative selection	2191574
88840078	88840101	15	-	26627737	HCT116	viability after 18 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	0.5513771167366814	[95]	[47,127,21]	4	hSpCas9	negative selection	2191575
88841756	88841779	15	-	26627737	HCT116	viability after 18 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-1.672783519698192	[599]	[75,147,42]	-8	hSpCas9	negative selection	2191576
88843539	88843562	15	-	26627737	HCT116	viability after 18 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-0.2305565014809572	[120]	[41,57,48]	-2	hSpCas9	negative selection	2191577
88845859	88845882	15	+	26627737	HCT116	viability after 18 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	-0.09245729437419647	[552]	[354,115,291]	-1	hSpCas9	negative selection	2191578
88847352	88847375	15	-	26627737	HCT116	viability after 18 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	0.33681481392326806	[91]	[38,41,89]	3	hSpCas9	negative selection	2191579
88849665	88849688	15	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CTACCTCTACCCTAACCAGACGG	ACAN	ENSG00000157766	0.026623842142424886	[2,3]	[3,1]	0	hSpCas9	positive selection	2968403
88855397	88855420	15	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TCTAGGATCTCAGCTCCAGAGGG	ACAN	ENSG00000157766	-0.22280700072830986	[3,3]	[3,1]	-3	hSpCas9	positive selection	2968404
88841837	88841860	15	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TGATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	-0.24522386079147646	[3,3]	[2,1]	-3	hSpCas9	positive selection	2968405
88838985	88839008	15	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TGCCATGCATCACCTCGCAGCGG	ACAN	ENSG00000157766	-0.055292716376233675	[3,2]	[4,0]	-1	hSpCas9	positive selection	2968406
88849665	88849688	15	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CTACCTCTACCCTAACCAGACGG	ACAN	ENSG00000157766	-0.180454266856418	[2,2]	[3,0]	-3	hSpCas9	positive selection	3036261
88855397	88855420	15	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TCTAGGATCTCAGCTCCAGAGGG	ACAN	ENSG00000157766	0.18209836247415556	[3,3]	[2,2]	3	hSpCas9	positive selection	3036262
88841837	88841860	15	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TGATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	0.3149961631105391	[3,3]	[4,2]	5	hSpCas9	positive selection	3036263
88838985	88839008	15	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TGCCATGCATCACCTCGCAGCGG	ACAN	ENSG00000157766	-0.7390943173129926	[3,3]	[2,0]	-8	hSpCas9	positive selection	3036264
88836211	88836234		-	24336571	A375	resistance to PLX after 7 days	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	-0.014226370552887557	[5,5]	[5,5]	0	hSpCas9	positive selection	3147680
88838778	88838801		+	24336571	A375	resistance to PLX after 7 days	CGCCCCTTCTACCGCCCCACTGG	ACAN	ENSG00000157766	-0.2681739609197791	[61,55]	[46,50]	-7	hSpCas9	positive selection	3147789
88838858	88838881		-	24336571	A375	resistance to PLX after 7 days	GACCCGCACGCGCCCTTCAGTGG	ACAN	ENSG00000157766	0.123483321777909	[16,13]	[16,15]	4	hSpCas9	positive selection	3147898
88836211	88836234		-	24336571	A375	resistance to PLX after 14 days	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.0688320261394606	[2,6]	[1,1]	0	hSpCas9	positive selection	3205473
88838778	88838801		+	24336571	A375	resistance to PLX after 14 days	CGCCCCTTCTACCGCCCCACTGG	ACAN	ENSG00000157766	-0.3366485965782897	[61,50]	[19,21]	-4	hSpCas9	positive selection	3205582
88838858	88838881		-	24336571	A375	resistance to PLX after 14 days	GACCCGCACGCGCCCTTCAGTGG	ACAN	ENSG00000157766	0.10529056315970686	[17,21]	[8,9]	1	hSpCas9	positive selection	3205691
88836211	88836234		-	24336571	A375	viability after 7 days	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	-0.7065473951431012	[9]	[5,5]	-7	hSpCas9	negative selection	3263266
88838778	88838801		+	24336571	A375	viability after 7 days	CGCCCCTTCTACCGCCCCACTGG	ACAN	ENSG00000157766	0.24876038803349787	[51]	[61,55]	4	hSpCas9	negative selection	3263375
88838858	88838881		-	24336571	A375	viability after 7 days	GACCCGCACGCGCCCTTCAGTGG	ACAN	ENSG00000157766	-0.5596247992768986	[23]	[16,13]	-7	hSpCas9	negative selection	3263484
88836211	88836234		-	24336571	A375	viability after 14 days	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	-0.847604388820943	[9]	[2,6]	-8	hSpCas9	negative selection	3321059
88838778	88838801		+	24336571	A375	viability after 14 days	CGCCCCTTCTACCGCCCCACTGG	ACAN	ENSG00000157766	0.20812654011022835	[51]	[61,50]	2	hSpCas9	negative selection	3321168
88838858	88838881		-	24336571	A375	viability after 14 days	GACCCGCACGCGCCCTTCAGTGG	ACAN	ENSG00000157766	-0.1760589046974006	[23]	[17,21]	-2	hSpCas9	negative selection	3321277
88840045	88840068	15	+	27383988	293T	resistance to West Nile virus (flavivirus)	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	2.9144437287270684	[309,216]	[24,0]	8	hSpCas9	positive selection	3335189
88838874	88838897	15	+	27383988	293T	resistance to West Nile virus (flavivirus)	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	-0.47977197727410525	[190,235]	[0,0]	-3	hSpCas9	positive selection	3335190
88838958	88838981	15	-	27383988	293T	resistance to West Nile virus (flavivirus)	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	0.7589919004962052	[75,104]	[0,0]	3	hSpCas9	positive selection	3335191
88840052	88840075	15	-	27383988	293T	resistance to West Nile virus (flavivirus)	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	1.148801754667666	[68,68]	[0,0]	5	hSpCas9	positive selection	3354438
88836202	88836225	15	+	27383988	293T	resistance to West Nile virus (flavivirus)	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.9324983474341821	[291,291]	[0,0]	-6	hSpCas9	positive selection	3354439
88836211	88836234	15	-	27383988	293T	resistance to West Nile virus (flavivirus)	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	2.2129320920873816	[32,32]	[0,0]	7	hSpCas9	positive selection	3354440
88849664	88849687	15	+	26780180	HT29	viability (Avana library 4 designs)	CTACCTCTACCCTAACCAGACGG	ACAN	ENSG00000157766	0.343481989339985	[]	[]	1	hSpCas9	negative selection	3404347
88855397	88855420	15	-	26780180	HT29	viability (Avana library 4 designs)	TCTAGGATCTCAGCTCCAGAGGG	ACAN	ENSG00000157766	0.0910864942753436	[]	[]	0	hSpCas9	negative selection	3404348
88841836	88841859	15	+	26780180	HT29	viability (Avana library 4 designs)	TGATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	3.16134675447824	[]	[]	8	hSpCas9	negative selection	3404349
88838985	88839008	15	-	26780180	HT29	viability (Avana library 4 designs)	TGCCATGCATCACCTCGCAGCGG	ACAN	ENSG00000157766	0.538951976988277	[]	[]	2	hSpCas9	negative selection	3404350
88841836	88841859	15	+	26780180	A375	viability (Avana lentiCRISPRv2)	TGATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	-3.74325099529118	[]	[]	-4	hSpCas9	negative selection	3475840
88855397	88855420	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	TCTAGGATCTCAGCTCCAGAGGG	ACAN	ENSG00000157766	-1.71461957851585	[]	[]	-2	hSpCas9	negative selection	3475841
88838985	88839008	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	TGCCATGCATCACCTCGCAGCGG	ACAN	ENSG00000157766	-3.54708935547829	[]	[]	-4	hSpCas9	negative selection	3475842
88849664	88849687	15	+	26780180	A375	viability (Avana lentiCRISPRv2)	CTACCTCTACCCTAACCAGACGG	ACAN	ENSG00000157766	-3.97626007656447	[]	[]	-4	hSpCas9	negative selection	3475843
88855400	88855423	15	+	26780180	A375	viability (Avana lentiCRISPRv2)	TCTGGAGCTGAGATCCTAGAGGG	ACAN	ENSG00000157766	1.01163412311387	[]	[]	1	hSpCas9	negative selection	3475844
88855095	88855118	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	AGGTGTATACGGCTCTTCCGAGG	ACAN	ENSG00000157766	3.50054618902173	[]	[]	5	hSpCas9	negative selection	3475845
88841836	88841859	15	+	26780180	A375	viability (Avana lentiGuide)	TGATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	-0.258385607836221	[]	[]	0	hSpCas9	negative selection	3584499
88855397	88855420	15	-	26780180	A375	viability (Avana lentiGuide)	TCTAGGATCTCAGCTCCAGAGGG	ACAN	ENSG00000157766	-4.29988178310159	[]	[]	-7	hSpCas9	negative selection	3584500
88838985	88839008	15	-	26780180	A375	viability (Avana lentiGuide)	TGCCATGCATCACCTCGCAGCGG	ACAN	ENSG00000157766	-1.41210883748966	[]	[]	-2	hSpCas9	negative selection	3584501
88849664	88849687	15	+	26780180	A375	viability (Avana lentiGuide)	CTACCTCTACCCTAACCAGACGG	ACAN	ENSG00000157766	1.57433734104216	[]	[]	1	hSpCas9	negative selection	3584502
88855400	88855423	15	+	26780180	A375	viability (Avana lentiGuide)	TCTGGAGCTGAGATCCTAGAGGG	ACAN	ENSG00000157766	-5.56047598290382	[]	[]	-8	hSpCas9	negative selection	3584503
88855095	88855118	15	-	26780180	A375	viability (Avana lentiGuide)	AGGTGTATACGGCTCTTCCGAGG	ACAN	ENSG00000157766	2.11711990941297	[]	[]	2	hSpCas9	negative selection	3584504
88841836	88841859	15	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	-0.34514046108726076	[5]	[4,2]	-5	hSpCas9	positive selection	3693158
88855397	88855420	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TCTAGGATCTCAGCTCCAGAGGG	ACAN	ENSG00000157766	-0.19912758028352506	[5]	[7,2]	-3	hSpCas9	positive selection	3693159
88838985	88839008	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGCCATGCATCACCTCGCAGCGG	ACAN	ENSG00000157766	-0.8003025510529405	[4]	[2,1]	-8	hSpCas9	positive selection	3693160
88849664	88849687	15	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTACCTCTACCCTAACCAGACGG	ACAN	ENSG00000157766	-0.31946718167046295	[5]	[3,3]	-5	hSpCas9	positive selection	3693161
88855400	88855423	15	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TCTGGAGCTGAGATCCTAGAGGG	ACAN	ENSG00000157766	-0.007562012208352913	[5]	[5,4]	0	hSpCas9	positive selection	3693162
88855095	88855118	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGGTGTATACGGCTCTTCCGAGG	ACAN	ENSG00000157766	0.05884417273281667	[5]	[5,4]	1	hSpCas9	positive selection	3693163
88841836	88841859	15	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	-0.3859873903999371	[5]	[3,2]	-5	hSpCas9	positive selection	3801765
88855397	88855420	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TCTAGGATCTCAGCTCCAGAGGG	ACAN	ENSG00000157766	-0.16234562809804332	[5]	[4,3]	-2	hSpCas9	positive selection	3801766
88838985	88839008	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGCCATGCATCACCTCGCAGCGG	ACAN	ENSG00000157766	0.5638578184539718	[4]	[2,9]	9	hSpCas9	positive selection	3801767
88849664	88849687	15	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTACCTCTACCCTAACCAGACGG	ACAN	ENSG00000157766	-0.006356797955437518	[4]	[4,3]	0	hSpCas9	positive selection	3801768
88855400	88855423	15	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TCTGGAGCTGAGATCCTAGAGGG	ACAN	ENSG00000157766	0.3374404599008768	[5]	[5,5]	8	hSpCas9	positive selection	3801769
88855095	88855118	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGGTGTATACGGCTCTTCCGAGG	ACAN	ENSG00000157766	0.15011731232318526	[5]	[5,4]	3	hSpCas9	positive selection	3801770
88836211	88836234	15	-	26780180	A375	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.403867580556078	[]	[]	1	hSpCas9	negative selection	3910368
88838958	88838981	15	-	26780180	A375	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	1.63455202122192	[]	[]	8	hSpCas9	negative selection	3910369
88836202	88836225	15	+	26780180	A375	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	1.11851761869553	[]	[]	5	hSpCas9	negative selection	3910370
88838874	88838897	15	+	26780180	A375	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.933682266276434	[]	[]	4	hSpCas9	negative selection	3910371
88840045	88840068	15	+	26780180	A375	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.557925599247805	[]	[]	1	hSpCas9	negative selection	3910372
88840052	88840075	15	-	26780180	A375	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	1.06024579110735	[]	[]	5	hSpCas9	negative selection	3910373
88836211	88836234	15	-	26780180	HT29	viability (GeCKOv2 library)	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.4926237512507	[]	[]	1	hSpCas9	negative selection	4018334
88838958	88838981	15	-	26780180	HT29	viability (GeCKOv2 library)	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	1.52898979343239	[]	[]	7	hSpCas9	negative selection	4018335
88836202	88836225	15	+	26780180	HT29	viability (GeCKOv2 library)	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	1.25029424035265	[]	[]	6	hSpCas9	negative selection	4018336
88838874	88838897	15	+	26780180	HT29	viability (GeCKOv2 library)	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	1.03547259352863	[]	[]	5	hSpCas9	negative selection	4018337
88840045	88840068	15	+	26780180	HT29	viability (GeCKOv2 library)	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.476104535127623	[]	[]	1	hSpCas9	negative selection	4018338
88840052	88840075	15	-	26780180	HT29	viability (GeCKOv2 library)	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.953565529881043	[]	[]	4	hSpCas9	negative selection	4018339
88836211	88836234	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.009545163737864848	[2]	[1,0]	0	hSpCas9	positive selection	4173903
88838778	88838801	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CGCCCCTTCTACCGCCCCACTGG	ACAN	ENSG00000157766	0.12062505085847997	[5]	[4,4]	3	hSpCas9	positive selection	4174014
88838858	88838881	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GACCCGCACGCGCCCTTCAGTGG	ACAN	ENSG00000157766	0.1303308265462746	[4]	[2,3]	3	hSpCas9	positive selection	4174124
88836211	88836234	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	1.6490710113243132	[2]	[2,2,5,4]	9	hSpCas9	positive selection	4237925
88838778	88838801	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CGCCCCTTCTACCGCCCCACTGG	ACAN	ENSG00000157766	0.6897620933088474	[5]	[5,0,2,4]	4	hSpCas9	positive selection	4238036
88838858	88838881	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GACCCGCACGCGCCCTTCAGTGG	ACAN	ENSG00000157766	0.8559009885993335	[4]	[1,2,2,4]	5	hSpCas9	positive selection	4238146
88840045	88840068	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.38701700805458145	[3]	[4,3]	7	hSpCas9	positive selection	4254083
88838874	88838897	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.14390554025807248	[3]	[2,2]	3	hSpCas9	positive selection	4254084
88838958	88838981	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.18312396969549075	[3]	[3,0]	-4	hSpCas9	positive selection	4254085
88840052	88840075	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.033152052482685435	[2]	[1,1]	0	hSpCas9	positive selection	4318367
88836202	88836225	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	0.14483602938506213	[3]	[3,2]	3	hSpCas9	positive selection	4318368
88836211	88836234	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.39387021473926687	[0]	[1,0]	7	hSpCas9	positive selection	4318369
88841837	88841859	15	+	27760321	OCIAML3	viability	GATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	0.12702862736276632	[1103,906]	[598,1187]	1	hSpCas9	negative selection	4375508
88843614	88843636	15	-	27760321	OCIAML3	viability	GGCGTCGTAGCGGGATGAGGGG	ACAN	ENSG00000157766	-0.0692796295041384	[654,583]	[405,532]	0	hSpCas9	negative selection	4375509
88847313	88847335	15	-	27760321	OCIAML3	viability	AATGACCGCCCCCGTGCGCAGG	ACAN	ENSG00000157766	-0.29811051604515426	[844,677]	[343,660]	-3	hSpCas9	negative selection	4375510
88847406	88847428	15	-	27760321	OCIAML3	viability	ATGGCTTCACCTGACGGTCTGG	ACAN	ENSG00000157766	0.5568373359184464	[872,762]	[849,1054]	6	hSpCas9	negative selection	4375511
88849647	88849669	15	-	27760321	OCIAML3	viability	GGTAGACCGTTCTCACGCCTGG	ACAN	ENSG00000157766	-0.34376405053075676	[794,674]	[463,434]	-4	hSpCas9	negative selection	4375512
88841837	88841859	15	+	27760321	OCIAML2	viability	GATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	0.20451360341191527	[1103,906]	[748,1174]	2	hSpCas9	negative selection	4458971
88843614	88843636	15	-	27760321	OCIAML2	viability	GGCGTCGTAGCGGGATGAGGGG	ACAN	ENSG00000157766	0.049475027147117046	[654,583]	[469,580]	0	hSpCas9	negative selection	4458972
88847313	88847335	15	-	27760321	OCIAML2	viability	AATGACCGCCCCCGTGCGCAGG	ACAN	ENSG00000157766	-0.05636894234293177	[844,677]	[500,704]	0	hSpCas9	negative selection	4458973
88847406	88847428	15	-	27760321	OCIAML2	viability	ATGGCTTCACCTGACGGTCTGG	ACAN	ENSG00000157766	0.4183851616417189	[872,762]	[805,982]	6	hSpCas9	negative selection	4458974
88849647	88849669	15	-	27760321	OCIAML2	viability	GGTAGACCGTTCTCACGCCTGG	ACAN	ENSG00000157766	0.02540498958818671	[794,674]	[486,755]	0	hSpCas9	negative selection	4458975
88841837	88841859	15	+	27760321	MV411	viability	GATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	-0.4777952837044773	[1103,906]	[470,478]	-3	hSpCas9	negative selection	4542434
88843614	88843636	15	-	27760321	MV411	viability	GGCGTCGTAGCGGGATGAGGGG	ACAN	ENSG00000157766	-0.16159072619111742	[654,583]	[330,415]	-1	hSpCas9	negative selection	4542435
88847313	88847335	15	-	27760321	MV411	viability	AATGACCGCCCCCGTGCGCAGG	ACAN	ENSG00000157766	-0.30636100263393334	[844,677]	[222,675]	-2	hSpCas9	negative selection	4542436
88847406	88847428	15	-	27760321	MV411	viability	ATGGCTTCACCTGACGGTCTGG	ACAN	ENSG00000157766	0.5524195357642541	[872,762]	[872,664]	4	hSpCas9	negative selection	4542437
88849647	88849669	15	-	27760321	MV411	viability	GGTAGACCGTTCTCACGCCTGG	ACAN	ENSG00000157766	0.7658885278876584	[794,674]	[737,947]	5	hSpCas9	negative selection	4542438
88841837	88841859	15	+	27760321	HL60	viability	GATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	-0.21535468949209102	[1103,906]	[657,752]	-2	hSpCas9	negative selection	4625897
88843614	88843636	15	-	27760321	HL60	viability	GGCGTCGTAGCGGGATGAGGGG	ACAN	ENSG00000157766	0.005882363257844192	[654,583]	[586,422]	0	hSpCas9	negative selection	4625898
88847313	88847335	15	-	27760321	HL60	viability	AATGACCGCCCCCGTGCGCAGG	ACAN	ENSG00000157766	-0.7572503556045956	[844,677]	[329,403]	-7	hSpCas9	negative selection	4625899
88847406	88847428	15	-	27760321	HL60	viability	ATGGCTTCACCTGACGGTCTGG	ACAN	ENSG00000157766	0.27490614072169284	[872,762]	[894,712]	3	hSpCas9	negative selection	4625900
88849647	88849669	15	-	27760321	HL60	viability	GGTAGACCGTTCTCACGCCTGG	ACAN	ENSG00000157766	-0.10494696188711716	[794,674]	[634,472]	-1	hSpCas9	negative selection	4625901
88841837	88841859	15	+	27760321	HT1080	viability	GATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	0.47145104612690214	[906,707]	[456,433]	2	hSpCas9	negative selection	4709360
88843614	88843636	15	-	27760321	HT1080	viability	GGCGTCGTAGCGGGATGAGGGG	ACAN	ENSG00000157766	-0.3521066339282598	[583,455]	[157,166]	-2	hSpCas9	negative selection	4709361
88847313	88847335	15	-	27760321	HT1080	viability	AATGACCGCCCCCGTGCGCAGG	ACAN	ENSG00000157766	0.9303417080333055	[677,528]	[587,315]	5	hSpCas9	negative selection	4709362
88847406	88847428	15	-	27760321	HT1080	viability	ATGGCTTCACCTGACGGTCTGG	ACAN	ENSG00000157766	0.18808993406317043	[762,595]	[337,275]	0	hSpCas9	negative selection	4709363
88849647	88849669	15	-	27760321	HT1080	viability	GGTAGACCGTTCTCACGCCTGG	ACAN	ENSG00000157766	0.8694218407379578	[674,526]	[403,473]	5	hSpCas9	negative selection	4709364
88841837	88841859	15	+	27760321	HT29	viability after 7 days	GATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	-0.353240582235297	[906,707]	[946,848,664]	-5	hSpCas9	negative selection	4792823
88843614	88843636	15	-	27760321	HT29	viability after 7 days	GGCGTCGTAGCGGGATGAGGGG	ACAN	ENSG00000157766	0.1460795090541982	[583,455]	[897,730,615]	2	hSpCas9	negative selection	4792824
88847313	88847335	15	-	27760321	HT29	viability after 7 days	AATGACCGCCCCCGTGCGCAGG	ACAN	ENSG00000157766	0.05110283139887872	[677,528]	[822,937,656]	0	hSpCas9	negative selection	4792825
88847406	88847428	15	-	27760321	HT29	viability after 7 days	ATGGCTTCACCTGACGGTCTGG	ACAN	ENSG00000157766	0.2273057605606209	[762,595]	[1085,716,1264]	3	hSpCas9	negative selection	4792826
88849647	88849669	15	-	27760321	HT29	viability after 7 days	GGTAGACCGTTCTCACGCCTGG	ACAN	ENSG00000157766	-0.07823686664059137	[674,526]	[888,781,551]	-1	hSpCas9	negative selection	4792827
88841837	88841859	15	+	27760321	HT29	viability after 25 days	GATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	0.05293825089524207	[906,707]	[856,1069,948]	0	hSpCas9	negative selection	4876286
88843614	88843636	15	-	27760321	HT29	viability after 25 days	GGCGTCGTAGCGGGATGAGGGG	ACAN	ENSG00000157766	0.362715115750065	[583,455]	[686,768,848]	4	hSpCas9	negative selection	4876287
88847313	88847335	15	-	27760321	HT29	viability after 25 days	AATGACCGCCCCCGTGCGCAGG	ACAN	ENSG00000157766	-0.27536500706208006	[677,528]	[478,711,517]	-3	hSpCas9	negative selection	4876288
88847406	88847428	15	-	27760321	HT29	viability after 25 days	ATGGCTTCACCTGACGGTCTGG	ACAN	ENSG00000157766	0.6447970981545109	[762,595]	[1394,1040,1190]	7	hSpCas9	negative selection	4876289
88849647	88849669	15	-	27760321	HT29	viability after 25 days	GGTAGACCGTTCTCACGCCTGG	ACAN	ENSG00000157766	-0.1636065502365346	[674,526]	[473,729,646]	-2	hSpCas9	negative selection	4876290
88841837	88841859	15	+	27760321	HT29	viability after 22 days	GATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	0.12137531336124963	[906,707]	[968,1123,953]	1	hSpCas9	negative selection	4959749
88843614	88843636	15	-	27760321	HT29	viability after 22 days	GGCGTCGTAGCGGGATGAGGGG	ACAN	ENSG00000157766	-0.2025406749537385	[583,455]	[450,613,503]	-2	hSpCas9	negative selection	4959750
88847313	88847335	15	-	27760321	HT29	viability after 22 days	AATGACCGCCCCCGTGCGCAGG	ACAN	ENSG00000157766	-0.17397186971015943	[677,528]	[733,611,504]	-2	hSpCas9	negative selection	4959751
88847406	88847428	15	-	27760321	HT29	viability after 22 days	ATGGCTTCACCTGACGGTCTGG	ACAN	ENSG00000157766	0.41983295181035307	[762,595]	[955,969,1230]	4	hSpCas9	negative selection	4959752
88849647	88849669	15	-	27760321	HT29	viability after 22 days	GGTAGACCGTTCTCACGCCTGG	ACAN	ENSG00000157766	-0.04159769180736683	[674,526]	[528,728,771]	0	hSpCas9	negative selection	4959753
88841837	88841859	15	+	27760321	HT29	viability after 19 days	GATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	-0.1395033064605682	[906,707]	[740,1019,746]	-1	hSpCas9	negative selection	5043212
88843614	88843636	15	-	27760321	HT29	viability after 19 days	GGCGTCGTAGCGGGATGAGGGG	ACAN	ENSG00000157766	0.5413296541767437	[583,455]	[752,799,1024]	5	hSpCas9	negative selection	5043213
88847313	88847335	15	-	27760321	HT29	viability after 19 days	AATGACCGCCCCCGTGCGCAGG	ACAN	ENSG00000157766	-0.5516333688746333	[677,528]	[502,449,462]	-5	hSpCas9	negative selection	5043214
88847406	88847428	15	-	27760321	HT29	viability after 19 days	ATGGCTTCACCTGACGGTCTGG	ACAN	ENSG00000157766	0.370969538117926	[762,595]	[1083,1047,894]	3	hSpCas9	negative selection	5043215
88849647	88849669	15	-	27760321	HT29	viability after 19 days	GGTAGACCGTTCTCACGCCTGG	ACAN	ENSG00000157766	-0.03402598059171802	[674,526]	[750,467,797]	0	hSpCas9	negative selection	5043216
88841837	88841859	15	+	27760321	HT29	viability after 16 days	GATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	0.050440622390522716	[906,707]	[836,908,1051]	0	hSpCas9	negative selection	5126675
88843614	88843636	15	-	27760321	HT29	viability after 16 days	GGCGTCGTAGCGGGATGAGGGG	ACAN	ENSG00000157766	-0.28512728765472783	[583,455]	[451,511,464]	-3	hSpCas9	negative selection	5126676
88847313	88847335	15	-	27760321	HT29	viability after 16 days	AATGACCGCCCCCGTGCGCAGG	ACAN	ENSG00000157766	-0.387638686763505	[677,528]	[640,439,480]	-4	hSpCas9	negative selection	5126677
88847406	88847428	15	-	27760321	HT29	viability after 16 days	ATGGCTTCACCTGACGGTCTGG	ACAN	ENSG00000157766	0.10034157275093325	[762,595]	[923,632,902]	1	hSpCas9	negative selection	5126678
88849647	88849669	15	-	27760321	HT29	viability after 16 days	GGTAGACCGTTCTCACGCCTGG	ACAN	ENSG00000157766	-0.35769146196069135	[674,526]	[515,653,399]	-4	hSpCas9	negative selection	5126679
88841837	88841859	15	+	27760321	HT29	viability after 13 days	GATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	-0.08083940690444713	[906,707]	[1183,869,618]	-1	hSpCas9	negative selection	5210138
88843614	88843636	15	-	27760321	HT29	viability after 13 days	GGCGTCGTAGCGGGATGAGGGG	ACAN	ENSG00000157766	0.31867261446549	[583,455]	[1062,503,692]	4	hSpCas9	negative selection	5210139
88847313	88847335	15	-	27760321	HT29	viability after 13 days	AATGACCGCCCCCGTGCGCAGG	ACAN	ENSG00000157766	-0.4353543322906055	[677,528]	[591,409,548]	-5	hSpCas9	negative selection	5210140
88847406	88847428	15	-	27760321	HT29	viability after 13 days	ATGGCTTCACCTGACGGTCTGG	ACAN	ENSG00000157766	0.19642997994281253	[762,595]	[933,757,1010]	2	hSpCas9	negative selection	5210141
88849647	88849669	15	-	27760321	HT29	viability after 13 days	GGTAGACCGTTCTCACGCCTGG	ACAN	ENSG00000157766	0.05949924143775831	[674,526]	[897,771,521]	0	hSpCas9	negative selection	5210142
88841837	88841859	15	+	27760321	HT29	viability after 10 days	GATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	-0.0016155870391807436	[906,707]	[888,1137,997]	0	hSpCas9	negative selection	5293601
88843614	88843636	15	-	27760321	HT29	viability after 10 days	GGCGTCGTAGCGGGATGAGGGG	ACAN	ENSG00000157766	0.27886448044174905	[583,455]	[696,867,799]	4	hSpCas9	negative selection	5293602
88847313	88847335	15	-	27760321	HT29	viability after 10 days	AATGACCGCCCCCGTGCGCAGG	ACAN	ENSG00000157766	0.021920929567959324	[677,528]	[749,892,657]	0	hSpCas9	negative selection	5293603
88847406	88847428	15	-	27760321	HT29	viability after 10 days	ATGGCTTCACCTGACGGTCTGG	ACAN	ENSG00000157766	0.1129146182776789	[762,595]	[912,931,907]	1	hSpCas9	negative selection	5293604
88849647	88849669	15	-	27760321	HT29	viability after 10 days	GGTAGACCGTTCTCACGCCTGG	ACAN	ENSG00000157766	-0.36508167421437054	[674,526]	[402,1007,353]	-5	hSpCas9	negative selection	5293605
88841837	88841859	15	+	27760321	MOLM13	viability	GATGTGTACTGCTTCGCCGAGG	ACAN	ENSG00000157766	0.27482916946869484	[1103,906]	[950,454]	1	hSpCas9	negative selection	5377064
88843614	88843636	15	-	27760321	MOLM13	viability	GGCGTCGTAGCGGGATGAGGGG	ACAN	ENSG00000157766	0.7266173792031484	[654,583]	[354,766]	5	hSpCas9	negative selection	5377065
88847313	88847335	15	-	27760321	MOLM13	viability	AATGACCGCCCCCGTGCGCAGG	ACAN	ENSG00000157766	0.9586929809686	[844,677]	[1095,603]	6	hSpCas9	negative selection	5377066
88847406	88847428	15	-	27760321	MOLM13	viability	ATGGCTTCACCTGACGGTCTGG	ACAN	ENSG00000157766	0.6018155378454146	[872,762]	[579,799]	4	hSpCas9	negative selection	5377067
88849647	88849669	15	-	27760321	MOLM13	viability	GGTAGACCGTTCTCACGCCTGG	ACAN	ENSG00000157766	0.14150553228252083	[794,674]	[403,499]	1	hSpCas9	negative selection	5377068
88803486	88803509	15	+	27661255	K562	viability	GACGCGCGCAGCGCTGCTCAAGG	ACAN	ENSG00000157766	-0.547591929457746	[188,133]	[104,74]	-8	dCas9-KRAB	negative selection	5460394
88803849	88803872	15	+	27661255	K562	viability	GCGCCCGGCGAGCCAGGAACGGG	ACAN	ENSG00000157766	0.4188328650121847	[758,750]	[888,735]	9	dCas9-KRAB	negative selection	5460395
88803441	88803464	15	-	27661255	K562	viability	GGAGCGGCGGGGAGGTAGGTGGG	ACAN	ENSG00000157766	0.3896947182581222	[421,570]	[539,496]	9	dCas9-KRAB	negative selection	5460396
88803828	88803851	15	-	27661255	K562	viability	GCCCTGGGAGAGCCTCGCTCTGG	ACAN	ENSG00000157766	0.3918280181458038	[79,63]	[105,49]	9	dCas9-KRAB	negative selection	5460397
88840045	88840068	15	+	27260156	BXPC3	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	-0.15092332474000625	[973]	[747,1031,764,1155]	-3	hSpCas9	negative selection	5526543
88838874	88838897	15	+	27260156	BXPC3	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.3285671664808796	[539]	[592,787,730,729]	7	hSpCas9	negative selection	5526544
88838958	88838981	15	-	27260156	BXPC3	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.06244420375275263	[478]	[398,423,518,600]	-1	hSpCas9	negative selection	5526545
88840052	88840075	15	-	27260156	BXPC3	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.1068787375247442	[209]	[170,210,258,322]	2	hSpCas9	negative selection	5590827
88836202	88836225	15	+	27260156	BXPC3	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.20504294284374025	[867]	[779,670,714,1011]	-5	hSpCas9	negative selection	5590828
88836211	88836234	15	-	27260156	BXPC3	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.3166005041009736	[48]	[65,71,66,46]	7	hSpCas9	negative selection	5590829
88840045	88840068	15	+	27260156	A673	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.020561812444406247	[973]	[1239,1150,1231,1122]	0	hSpCas9	negative selection	5647794
88838874	88838897	15	+	27260156	A673	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.08917479778931905	[539]	[880,585,595,721]	2	hSpCas9	negative selection	5647795
88838958	88838981	15	-	27260156	A673	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	0.03633717694868975	[478]	[563,560,558,676]	0	hSpCas9	negative selection	5647796
88840052	88840075	15	-	27260156	A673	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.1873183867397633	[209]	[337,199,368,245]	4	hSpCas9	negative selection	5712078
88836202	88836225	15	+	27260156	A673	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.28839850508403186	[867]	[983,865,793,778]	-6	hSpCas9	negative selection	5712079
88836211	88836234	15	-	27260156	A673	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	-0.331182449407704	[48]	[50,61,30,42]	-7	hSpCas9	negative selection	5712080
88840045	88840068	15	+	27260156	A375	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.2641258385222316	[973]	[1330,1407,1461,1274]	4	hSpCas9	negative selection	5769045
88838874	88838897	15	+	27260156	A375	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.6905214223943232	[539]	[1125,1264,1028,718]	8	hSpCas9	negative selection	5769046
88838958	88838981	15	-	27260156	A375	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.19609975823708747	[478]	[566,492,498,403]	-3	hSpCas9	negative selection	5769047
88840052	88840075	15	-	27260156	A375	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.26973256335294993	[209]	[353,356,242,242]	4	hSpCas9	negative selection	5833329
88836202	88836225	15	+	27260156	A375	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.07618882328891863	[867]	[1090,948,1162,673]	-1	hSpCas9	negative selection	5833330
88836211	88836234	15	-	27260156	A375	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	-0.1996027153699118	[48]	[83,72,26,21]	-3	hSpCas9	negative selection	5833331
88840045	88840068	15	+	27260156	COLO741	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.027668751682478288	[973]	[1435,1254,1135]	0	hSpCas9	negative selection	5890296
88838874	88838897	15	+	27260156	COLO741	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	-1.0796712351199123	[539]	[416,310,262]	-9	hSpCas9	negative selection	5890297
88838958	88838981	15	-	27260156	COLO741	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.2786527808646318	[478]	[598,440,481]	-5	hSpCas9	negative selection	5890298
88840052	88840075	15	-	27260156	COLO741	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.02170220871707862	[209]	[256,287,247]	0	hSpCas9	negative selection	5954580
88836202	88836225	15	+	27260156	COLO741	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.2058680011385251	[867]	[1133,1026,751]	-4	hSpCas9	negative selection	5954581
88836211	88836234	15	-	27260156	COLO741	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.9272120745723869	[48]	[120,157,80]	9	hSpCas9	negative selection	5954582
88840045	88840068	15	+	27260156	CAL120	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.02800488232603615	[973]	[1257,1372,1081]	0	hSpCas9	negative selection	6011547
88838874	88838897	15	+	27260156	CAL120	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.2716890304548989	[539]	[1120,775,586]	4	hSpCas9	negative selection	6011548
88838958	88838981	15	-	27260156	CAL120	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.00887854259610988	[478]	[670,536,580]	0	hSpCas9	negative selection	6011549
88840052	88840075	15	-	27260156	CAL120	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.7211296620156706	[209]	[512,274,514]	9	hSpCas9	negative selection	6075831
88836202	88836225	15	+	27260156	CAL120	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.0341412673841055	[867]	[1051,1015,1094]	0	hSpCas9	negative selection	6075832
88836211	88836234	15	-	27260156	CAL120	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.0726473605987441	[48]	[77,83,32]	1	hSpCas9	negative selection	6075833
88840045	88840068	15	+	27260156	CADOES1	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.11587987997371818	[973]	[1029,944,978,971]	2	hSpCas9	negative selection	6132798
88838874	88838897	15	+	27260156	CADOES1	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.0768016618661578	[539]	[509,729,432,442]	1	hSpCas9	negative selection	6132799
88838958	88838981	15	-	27260156	CADOES1	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	0.2090692097961151	[478]	[571,635,515,328]	3	hSpCas9	negative selection	6132800
88840052	88840075	15	-	27260156	CADOES1	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.11950290197093771	[209]	[164,106,241,205]	-2	hSpCas9	negative selection	6197082
88836202	88836225	15	+	27260156	CADOES1	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.15658911409937637	[867]	[542,807,863,680]	-3	hSpCas9	negative selection	6197083
88836211	88836234	15	-	27260156	CADOES1	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	-0.5207649017327554	[48]	[35,39,20,29]	-7	hSpCas9	negative selection	6197084
88840045	88840068	15	+	27260156	EWS502	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.22891617633281536	[973]	[931,1098,1385,1473]	4	hSpCas9	negative selection	6254049
88838874	88838897	15	+	27260156	EWS502	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	-0.2549705911591052	[539]	[273,546,634,483]	-4	hSpCas9	negative selection	6254050
88838958	88838981	15	-	27260156	EWS502	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.007234207690457958	[478]	[475,450,530,569]	0	hSpCas9	negative selection	6254051
88840052	88840075	15	-	27260156	EWS502	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.05949945372496224	[209]	[145,216,252,247]	-1	hSpCas9	negative selection	6318333
88836202	88836225	15	+	27260156	EWS502	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.08114579804572941	[867]	[696,805,854,1158]	-1	hSpCas9	negative selection	6318334
88836211	88836234	15	-	27260156	EWS502	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.7150160222668855	[48]	[119,62,66,86]	9	hSpCas9	negative selection	6318335
88840045	88840068	15	+	27260156	EW8	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.16901771854053682	[973]	[1109,961,640,900]	3	hSpCas9	negative selection	6375300
88838874	88838897	15	+	27260156	EW8	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.5170619831351357	[539]	[808,491,486,757]	8	hSpCas9	negative selection	6375301
88838958	88838981	15	-	27260156	EW8	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.058880287602682144	[478]	[532,292,372,307]	-1	hSpCas9	negative selection	6375302
88840052	88840075	15	-	27260156	EW8	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.4129329807293233	[209]	[246,215,183,267]	7	hSpCas9	negative selection	6439584
88836202	88836225	15	+	27260156	EW8	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.25856058116639125	[867]	[567,530,603,641]	-5	hSpCas9	negative selection	6439585
88836211	88836234	15	-	27260156	EW8	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.5101300376546289	[48]	[68,49,58,48]	8	hSpCas9	negative selection	6439586
88840045	88840068	15	+	27260156	CORL105	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.1527581790863366	[973]	[1155,1052,1498,1397]	3	hSpCas9	negative selection	6496551
88838874	88838897	15	+	27260156	CORL105	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.5038139371851932	[539]	[677,950,1008,955]	8	hSpCas9	negative selection	6496552
88838958	88838981	15	-	27260156	CORL105	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.19342704513535838	[478]	[328,506,746,412]	-4	hSpCas9	negative selection	6496553
88840052	88840075	15	-	27260156	CORL105	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.20609327439966818	[209]	[254,180,259,165]	-4	hSpCas9	negative selection	6560835
88836202	88836225	15	+	27260156	CORL105	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.12413111793773679	[867]	[900,814,1039,990]	-2	hSpCas9	negative selection	6560836
88836211	88836234	15	-	27260156	CORL105	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.6546780652993349	[48]	[83,124,68,78]	9	hSpCas9	negative selection	6560837
88840045	88840068	15	+	27260156	HS294T	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.1679748825668299	[973]	[363,535,418,363]	2	hSpCas9	negative selection	6617802
88838874	88838897	15	+	27260156	HS294T	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.47488580834989513	[539]	[277,354,273,243]	6	hSpCas9	negative selection	6617803
88838958	88838981	15	-	27260156	HS294T	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	0.3724356372753761	[478]	[364,206,175,190]	5	hSpCas9	negative selection	6617804
88840052	88840075	15	-	27260156	HS294T	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.6227803778044009	[209]	[272,59,66,79]	7	hSpCas9	negative selection	6682086
88836202	88836225	15	+	27260156	HS294T	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.2896107961105645	[867]	[263,176,259,425]	-4	hSpCas9	negative selection	6682087
88836211	88836234	15	-	27260156	HS294T	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.3823301503158003	[48]	[22,26,22,25]	5	hSpCas9	negative selection	6682088
88840045	88840068	15	+	27260156	HCC44	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.18849192272700988	[973]	[1236,1213,1538,1079]	3	hSpCas9	negative selection	6739053
88838874	88838897	15	+	27260156	HCC44	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.24100010679459585	[539]	[731,688,821,662]	4	hSpCas9	negative selection	6739054
88838958	88838981	15	-	27260156	HCC44	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.21517502612033934	[478]	[534,503,409,406]	-4	hSpCas9	negative selection	6739055
88840052	88840075	15	-	27260156	HCC44	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.303036266836074	[209]	[265,219,286,399]	5	hSpCas9	negative selection	6803337
88836202	88836225	15	+	27260156	HCC44	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.19949539974823483	[867]	[860,715,963,908]	-3	hSpCas9	negative selection	6803338
88836211	88836234	15	-	27260156	HCC44	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	-0.29549970268324577	[48]	[75,40,32,31]	-5	hSpCas9	negative selection	6803339
88840045	88840068	15	+	27260156	G402	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.04524405553117594	[973]	[2047,1055,692,1212]	0	hSpCas9	negative selection	6860304
88838874	88838897	15	+	27260156	G402	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.28717135584668696	[539]	[1118,580,560,975]	3	hSpCas9	negative selection	6860305
88838958	88838981	15	-	27260156	G402	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.01616199823265769	[478]	[944,659,366,403]	0	hSpCas9	negative selection	6860306
88840052	88840075	15	-	27260156	G402	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.047340454947155	[209]	[319,119,371,184]	0	hSpCas9	negative selection	6924588
88836202	88836225	15	+	27260156	G402	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	0.11968128075428652	[867]	[1251,1272,1532,589]	1	hSpCas9	negative selection	6924589
88836211	88836234	15	-	27260156	G402	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	-0.14002303812755867	[48]	[85,9,71,50]	-2	hSpCas9	negative selection	6924590
88840045	88840068	15	+	27260156	L33	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	-0.09826855615729702	[973]	[869,372,667,798]	-2	hSpCas9	negative selection	6981555
88838874	88838897	15	+	27260156	L33	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.30641393996276245	[539]	[506,312,423,728]	6	hSpCas9	negative selection	6981556
88838958	88838981	15	-	27260156	L33	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.1254299326679176	[478]	[571,170,169,491]	-3	hSpCas9	negative selection	6981557
88840052	88840075	15	-	27260156	L33	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.19546928388430884	[209]	[182,71,140,150]	-4	hSpCas9	negative selection	7045839
88836202	88836225	15	+	27260156	L33	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.43385561687275165	[867]	[684,282,411,538]	-8	hSpCas9	negative selection	7045840
88836211	88836234	15	-	27260156	L33	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.8248006577003806	[48]	[91,30,15,152]	9	hSpCas9	negative selection	7045841
88840045	88840068	15	+	27260156	K562	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.016869858020707396	[973]	[1096,727,900,788]	0	hSpCas9	negative selection	7102806
88838874	88838897	15	+	27260156	K562	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.32220552090197396	[539]	[609,424,744,604]	4	hSpCas9	negative selection	7102807
88838958	88838981	15	-	27260156	K562	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.4655037388442517	[478]	[321,531,231,172]	-5	hSpCas9	negative selection	7102808
88840052	88840075	15	-	27260156	K562	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.5956950665053334	[209]	[276,143,615,101]	7	hSpCas9	negative selection	7167090
88836202	88836225	15	+	27260156	K562	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.15414684252467692	[867]	[771,505,832,655]	-2	hSpCas9	negative selection	7167091
88836211	88836234	15	-	27260156	K562	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	-0.5713924218947217	[48]	[16,13,81,4]	-6	hSpCas9	negative selection	7167092
88840045	88840068	15	+	27260156	HT29	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.14408041979018327	[973]	[1470,1619,1140,1061]	2	hSpCas9	negative selection	7224057
88838874	88838897	15	+	27260156	HT29	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.27405082931402935	[539]	[801,963,808,629]	5	hSpCas9	negative selection	7224058
88838958	88838981	15	-	27260156	HT29	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.2200109291482801	[478]	[534,466,467,522]	-4	hSpCas9	negative selection	7224059
88840052	88840075	15	-	27260156	HT29	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.0769711147846388	[209]	[332,278,218,251]	1	hSpCas9	negative selection	7288341
88836202	88836225	15	+	27260156	HT29	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.12806810567469584	[867]	[998,1125,938,824]	-3	hSpCas9	negative selection	7288342
88836211	88836234	15	-	27260156	HT29	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.18905913607716496	[48]	[54,83,59,71]	3	hSpCas9	negative selection	7288343
88840045	88840068	15	+	27260156	MHHES1	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.14808848960824417	[973]	[1075,1665,1319,880]	2	hSpCas9	negative selection	7345308
88838874	88838897	15	+	27260156	MHHES1	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.5754181697931096	[539]	[851,1242,761,798]	8	hSpCas9	negative selection	7345309
88838958	88838981	15	-	27260156	MHHES1	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.26963342186771255	[478]	[475,533,393,398]	-5	hSpCas9	negative selection	7345310
88840052	88840075	15	-	27260156	MHHES1	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.4560379321519523	[209]	[124,200,265,106]	-7	hSpCas9	negative selection	7409592
88836202	88836225	15	+	27260156	MHHES1	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	0.22479605728124985	[867]	[848,1699,1440,684]	4	hSpCas9	negative selection	7409593
88836211	88836234	15	-	27260156	MHHES1	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.3033779548856912	[48]	[30,55,77,93]	5	hSpCas9	negative selection	7409594
88840045	88840068	15	+	27260156	MEWO	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.19717249997326336	[973]	[1298,859,1024]	4	hSpCas9	negative selection	7466559
88838874	88838897	15	+	27260156	MEWO	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.3565137623546809	[539]	[781,548,635]	7	hSpCas9	negative selection	7466560
88838958	88838981	15	-	27260156	MEWO	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	0.24320242935929057	[478]	[488,553,539]	5	hSpCas9	negative selection	7466561
88840052	88840075	15	-	27260156	MEWO	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.23544423878693577	[209]	[183,152,166]	-5	hSpCas9	negative selection	7530843
88836202	88836225	15	+	27260156	MEWO	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.31472134924322115	[867]	[782,607,592]	-6	hSpCas9	negative selection	7530844
88836211	88836234	15	-	27260156	MEWO	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.5309801850149247	[48]	[112,16,77]	9	hSpCas9	negative selection	7530845
88840045	88840068	15	+	27260156	LNCAPCLONEFGC	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.2331252274870277	[973]	[1049,968,1247,915]	3	hSpCas9	negative selection	7587810
88838874	88838897	15	+	27260156	LNCAPCLONEFGC	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	-0.19024910430753922	[539]	[421,355,552,406]	-3	hSpCas9	negative selection	7587811
88838958	88838981	15	-	27260156	LNCAPCLONEFGC	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.07554703603652696	[478]	[484,361,467,341]	-1	hSpCas9	negative selection	7587812
88840052	88840075	15	-	27260156	LNCAPCLONEFGC	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.206041013455043	[209]	[163,125,190,184]	-3	hSpCas9	negative selection	7652094
88836202	88836225	15	+	27260156	LNCAPCLONEFGC	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.09437343443473434	[867]	[638,790,791,729]	-1	hSpCas9	negative selection	7652095
88836211	88836234	15	-	27260156	LNCAPCLONEFGC	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	-0.004946706179790539	[48]	[12,16,95,60]	0	hSpCas9	negative selection	7652096
88840045	88840068	15	+	27260156	PANC0327	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.0703356165245248	[973]	[783,784,889,1179]	1	hSpCas9	negative selection	7709061
88838874	88838897	15	+	27260156	PANC0327	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.5576313160911923	[539]	[812,547,1123,368]	7	hSpCas9	negative selection	7709062
88838958	88838981	15	-	27260156	PANC0327	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	0.41266364089973184	[478]	[623,868,417,319]	6	hSpCas9	negative selection	7709063
88840052	88840075	15	-	27260156	PANC0327	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.016644817716337412	[209]	[319,142,150,139]	0	hSpCas9	negative selection	7773345
88836202	88836225	15	+	27260156	PANC0327	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	0.07602234181449419	[867]	[910,744,536,1073]	1	hSpCas9	negative selection	7773346
88836211	88836234	15	-	27260156	PANC0327	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	-0.18945880216772704	[48]	[9,48,57,31]	-3	hSpCas9	negative selection	7773347
88840045	88840068	15	+	27260156	NCIH2009	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.4039793715913793	[973]	[2265,1893,1328]	5	hSpCas9	negative selection	7830312
88838874	88838897	15	+	27260156	NCIH2009	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	-0.4429317295767726	[539]	[280,275,1057]	-5	hSpCas9	negative selection	7830313
88838958	88838981	15	-	27260156	NCIH2009	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.19224991070747183	[478]	[861,576,371]	-3	hSpCas9	negative selection	7830314
88840052	88840075	15	-	27260156	NCIH2009	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.06379063146296238	[209]	[319,193,336]	-1	hSpCas9	negative selection	7894596
88836202	88836225	15	+	27260156	NCIH2009	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.049848111456983535	[867]	[1200,976,1343]	0	hSpCas9	negative selection	7894597
88836211	88836234	15	-	27260156	NCIH2009	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.38849942413636906	[48]	[91,98,77]	5	hSpCas9	negative selection	7894598
88840045	88840068	15	+	27260156	NCIH1373	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.1158072994433943	[973]	[1199,1351,1422,183]	1	hSpCas9	negative selection	7951563
88838874	88838897	15	+	27260156	NCIH1373	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.7020996892833891	[539]	[1214,972,968,210]	7	hSpCas9	negative selection	7951564
88838958	88838981	15	-	27260156	NCIH1373	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.7000392830485751	[478]	[521,207,358,70]	-6	hSpCas9	negative selection	7951565
88840052	88840075	15	-	27260156	NCIH1373	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.28599754950893386	[209]	[162,435,230,73]	3	hSpCas9	negative selection	8015847
88836202	88836225	15	+	27260156	NCIH1373	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	0.22472117695238525	[867]	[1267,1235,990,276]	2	hSpCas9	negative selection	8015848
88836211	88836234	15	-	27260156	NCIH1373	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.5726706225882046	[48]	[286,16,7,13]	5	hSpCas9	negative selection	8015849
88840045	88840068	15	+	27260156	PATU8902	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.16710886497886301	[973]	[1763,1356,977,2199]	1	hSpCas9	negative selection	8072814
88838874	88838897	15	+	27260156	PATU8902	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.33965983165020486	[539]	[1230,767,768,1090]	3	hSpCas9	negative selection	8072815
88838958	88838981	15	-	27260156	PATU8902	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	0.2312940414828583	[478]	[835,933,690,675]	2	hSpCas9	negative selection	8072816
88840052	88840075	15	-	27260156	PATU8902	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.2996750957059313	[209]	[228,225,158,370]	-3	hSpCas9	negative selection	8137098
88836202	88836225	15	+	27260156	PATU8902	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	0.16360853312605028	[867]	[1374,1745,1125,1199]	1	hSpCas9	negative selection	8137099
88836211	88836234	15	-	27260156	PATU8902	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	-0.8639882016106939	[48]	[3,49,76,4]	-7	hSpCas9	negative selection	8137100
88840045	88840068	15	+	27260156	PANC1	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	-0.05713842058795737	[973]	[927,851,819,637]	-1	hSpCas9	negative selection	8194065
88838874	88838897	15	+	27260156	PANC1	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	-0.06723172551957488	[539]	[553,310,401,462]	-1	hSpCas9	negative selection	8194066
88838958	88838981	15	-	27260156	PANC1	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	0.0017926164824383743	[478]	[357,858,298,244]	0	hSpCas9	negative selection	8194067
88840052	88840075	15	-	27260156	PANC1	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.30084246748152366	[209]	[226,127,274,233]	5	hSpCas9	negative selection	8258349
88836202	88836225	15	+	27260156	PANC1	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	0.07230302938374045	[867]	[693,911,870,689]	1	hSpCas9	negative selection	8258350
88836211	88836234	15	-	27260156	PANC1	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	-0.22969765656775332	[48]	[16,24,27,65]	-4	hSpCas9	negative selection	8258351
88840045	88840068	15	+	27260156	PANC0813	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.21641100070509944	[973]	[1072,1642,1441,1143]	3	hSpCas9	negative selection	8315316
88838874	88838897	15	+	27260156	PANC0813	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.45552871782617654	[539]	[1003,852,887,751]	7	hSpCas9	negative selection	8315317
88838958	88838981	15	-	27260156	PANC0813	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.308175336336872	[478]	[578,418,441,391]	-5	hSpCas9	negative selection	8315318
88840052	88840075	15	-	27260156	PANC0813	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.05726918179331064	[209]	[337,128,205,354]	0	hSpCas9	negative selection	8379600
88836202	88836225	15	+	27260156	PANC0813	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.24751756680038106	[867]	[1167,999,649,654]	-4	hSpCas9	negative selection	8379601
88836211	88836234	15	-	27260156	PANC0813	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.8339580130773938	[48]	[99,97,108,102]	9	hSpCas9	negative selection	8379602
88840045	88840068	15	+	27260156	RDES	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.23359018056488368	[973]	[937,1182,1628,1636]	4	hSpCas9	negative selection	8436567
88838874	88838897	15	+	27260156	RDES	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.3921628299823058	[539]	[781,693,757,1051]	6	hSpCas9	negative selection	8436568
88838958	88838981	15	-	27260156	RDES	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.2079245641391185	[478]	[415,524,524,428]	-4	hSpCas9	negative selection	8436569
88840052	88840075	15	-	27260156	RDES	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.2217980175262595	[209]	[146,205,213,279]	-4	hSpCas9	negative selection	8500851
88836202	88836225	15	+	27260156	RDES	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.05019908302088194	[867]	[887,870,1094,1007]	-1	hSpCas9	negative selection	8500852
88836211	88836234	15	-	27260156	RDES	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.6343133939418943	[48]	[55,68,75,166]	8	hSpCas9	negative selection	8500853
88840045	88840068	15	+	27260156	PC3	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	-0.01893360016383605	[973]	[590,875,1536,1135]	0	hSpCas9	negative selection	8557818
88838874	88838897	15	+	27260156	PC3	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	-0.1649485850320638	[539]	[303,344,1058,476]	-4	hSpCas9	negative selection	8557819
88838958	88838981	15	-	27260156	PC3	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	0.12444917807476648	[478]	[383,360,925,582]	3	hSpCas9	negative selection	8557820
88840052	88840075	15	-	27260156	PC3	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.661555990585737	[209]	[169,180,781,424]	9	hSpCas9	negative selection	8622102
88836202	88836225	15	+	27260156	PC3	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.3969898214710165	[867]	[365,632,1290,656]	-7	hSpCas9	negative selection	8622103
88836211	88836234	15	-	27260156	PC3	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.5223225942126333	[48]	[67,51,160,24]	9	hSpCas9	negative selection	8622104
88840045	88840068	15	+	27260156	PATU8988T	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	-0.11042345692502642	[973]	[789,910,664,1149]	-2	hSpCas9	negative selection	8679069
88838874	88838897	15	+	27260156	PATU8988T	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.5159940143156425	[539]	[745,681,751,802]	8	hSpCas9	negative selection	8679070
88838958	88838981	15	-	27260156	PATU8988T	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.09317226834874963	[478]	[461,555,422,294]	-2	hSpCas9	negative selection	8679071
88840052	88840075	15	-	27260156	PATU8988T	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.20853836991289154	[209]	[135,151,297,106]	-4	hSpCas9	negative selection	8743353
88836202	88836225	15	+	27260156	PATU8988T	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.08724722014679764	[867]	[793,804,679,889]	-1	hSpCas9	negative selection	8743354
88836211	88836234	15	-	27260156	PATU8988T	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.40874673346415724	[48]	[17,92,40,105]	7	hSpCas9	negative selection	8743355
88840045	88840068	15	+	27260156	T47D	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.05466338878147092	[973]	[1227,1164,1236,1080]	1	hSpCas9	negative selection	8800320
88838874	88838897	15	+	27260156	T47D	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.24053759771378133	[539]	[854,615,643,874]	5	hSpCas9	negative selection	8800321
88838958	88838981	15	-	27260156	T47D	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.09969630606439352	[478]	[557,492,484,550]	-2	hSpCas9	negative selection	8800322
88840052	88840075	15	-	27260156	T47D	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.07547961295484096	[209]	[206,240,277,199]	-2	hSpCas9	negative selection	8864604
88836202	88836225	15	+	27260156	T47D	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.11003803457438055	[867]	[967,993,805,977]	-2	hSpCas9	negative selection	8864605
88836211	88836234	15	-	27260156	T47D	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.19095908020595775	[48]	[53,57,81,66]	4	hSpCas9	negative selection	8864606
88840045	88840068	15	+	27260156	SU8686	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.03953276371530978	[973]	[958,887,1182,947]	0	hSpCas9	negative selection	8921571
88838874	88838897	15	+	27260156	SU8686	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.49767822467893663	[539]	[765,589,684,1041]	8	hSpCas9	negative selection	8921572
88838958	88838981	15	-	27260156	SU8686	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.3955483338712098	[478]	[319,332,355,455]	-6	hSpCas9	negative selection	8921573
88840052	88840075	15	-	27260156	SU8686	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.156490539687679	[209]	[283,212,106,112]	-3	hSpCas9	negative selection	8985855
88836202	88836225	15	+	27260156	SU8686	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.015293473949507419	[867]	[816,742,892,987]	0	hSpCas9	negative selection	8985856
88836211	88836234	15	-	27260156	SU8686	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.6022464533667731	[48]	[57,30,107,111]	8	hSpCas9	negative selection	8985857
88840045	88840068	15	+	27260156	SKES1	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.15470478189755843	[973]	[1271,1062,871,1128]	3	hSpCas9	negative selection	9042822
88838874	88838897	15	+	27260156	SKES1	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	-0.08532072574911555	[539]	[510,604,467,459]	-2	hSpCas9	negative selection	9042823
88838958	88838981	15	-	27260156	SKES1	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.03533714310563361	[478]	[525,385,391,545]	0	hSpCas9	negative selection	9042824
88840052	88840075	15	-	27260156	SKES1	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	0.042153435096382585	[209]	[230,206,221,202]	0	hSpCas9	negative selection	9107106
88836202	88836225	15	+	27260156	SKES1	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.28551423334790405	[867]	[737,688,724,685]	-6	hSpCas9	negative selection	9107107
88836211	88836234	15	-	27260156	SKES1	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	1.0018100359590614	[48]	[101,173,35,89]	9	hSpCas9	negative selection	9107108
88840045	88840068	15	+	27260156	TOV112D	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.23417891138989688	[973]	[1034,1477,864,1277]	4	hSpCas9	negative selection	9164073
88838874	88838897	15	+	27260156	TOV112D	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.3075555722175306	[539]	[890,735,438,645]	6	hSpCas9	negative selection	9164074
88838958	88838981	15	-	27260156	TOV112D	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.04164157838588312	[478]	[519,324,325,656]	-1	hSpCas9	negative selection	9164075
88840052	88840075	15	-	27260156	TOV112D	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.2914202562924437	[209]	[213,163,183,127]	-5	hSpCas9	negative selection	9228357
88836202	88836225	15	+	27260156	TOV112D	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	0.19793702933491686	[867]	[1043,1470,861,737]	4	hSpCas9	negative selection	9228358
88836211	88836234	15	-	27260156	TOV112D	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	-0.2877666634152831	[48]	[49,37,31,40]	-5	hSpCas9	negative selection	9228359
88840045	88840068	15	+	27260156	TC71	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.0005494997042980732	[973]	[1066,963,1173,962]	0	hSpCas9	negative selection	9285324
88838874	88838897	15	+	27260156	TC71	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	0.1673287855121657	[539]	[688,611,620,679]	4	hSpCas9	negative selection	9285325
88838958	88838981	15	-	27260156	TC71	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.09796285752277914	[478]	[488,452,418,564]	-3	hSpCas9	negative selection	9285326
88840052	88840075	15	-	27260156	TC71	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.23920224871844975	[209]	[204,175,185,195]	-6	hSpCas9	negative selection	9349608
88836202	88836225	15	+	27260156	TC71	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.097354526845425	[867]	[869,806,858,947]	-2	hSpCas9	negative selection	9349609
88836211	88836234	15	-	27260156	TC71	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.6310407818865484	[48]	[75,117,45,86]	9	hSpCas9	negative selection	9349610
88840045	88840068	15	+	27260156	TC32	viability	GCTACACCCTCGACTTTGACAGG	ACAN	ENSG00000157766	0.1955920262046662	[973]	[1152,690,1147,1290]	3	hSpCas9	negative selection	9406575
88838874	88838897	15	+	27260156	TC32	viability	GCGGGTCAACAGTGCCTATCAGG	ACAN	ENSG00000157766	-0.07596255943863944	[539]	[555,388,465,507]	-1	hSpCas9	negative selection	9406576
88838958	88838981	15	-	27260156	TC32	viability	CCCCAGAGTCATTGGAGCGCAGG	ACAN	ENSG00000157766	-0.13975251121251875	[478]	[348,303,466,555]	-2	hSpCas9	negative selection	9406577
88840052	88840075	15	-	27260156	TC32	viability	GCTGCGCCCTGTCAAAGTCGAGG	ACAN	ENSG00000157766	-0.1351231492877023	[209]	[189,107,228,217]	-2	hSpCas9	negative selection	9470859
88836202	88836225	15	+	27260156	TC32	viability	GAACTATGACCACTTTACTCTGG	ACAN	ENSG00000157766	-0.3756059553646036	[867]	[684,370,835,717]	-6	hSpCas9	negative selection	9470860
88836211	88836234	15	-	27260156	TC32	viability	CACGAAAACCCAGAGTAAAGTGG	ACAN	ENSG00000157766	0.0986186039294239	[48]	[42,47,19,80]	1	hSpCas9	negative selection	9470861
88838817	88838840	15	+	27869803	HPAFII	viability after 27 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	-0.8163298218344509	[182]	[34,70,NaN]	-5	hSpCas9	negative selection	9555225
88840078	88840101	15	-	27869803	HPAFII	viability after 27 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	0.006394837552532007	[67]	[0,64,NaN]	0	hSpCas9	negative selection	9555226
88841756	88841779	15	-	27869803	HPAFII	viability after 27 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-1.2591342050304608	[494]	[147,75,NaN]	-7	hSpCas9	negative selection	9555227
88843539	88843562	15	-	27869803	HPAFII	viability after 27 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-1.088442807754457	[106]	[32,20,NaN]	-6	hSpCas9	negative selection	9555228
88845859	88845882	15	+	27869803	HPAFII	viability after 27 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	0.15330114515697651	[342]	[103,280,NaN]	1	hSpCas9	negative selection	9555229
88847352	88847375	15	-	27869803	HPAFII	viability after 27 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	0.463743656618405	[81]	[53,63,NaN]	4	hSpCas9	negative selection	9555230
88838817	88838840	15	+	27869803	HPAFII	viability after 15 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	-0.13194769407710927	[182]	[205,162,NaN]	-1	hSpCas9	negative selection	9637674
88840078	88840101	15	-	27869803	HPAFII	viability after 15 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	-0.8262585209117246	[67]	[47,36,NaN]	-7	hSpCas9	negative selection	9637675
88841756	88841779	15	-	27869803	HPAFII	viability after 15 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.6392933299876364	[494]	[372,321,NaN]	-6	hSpCas9	negative selection	9637676
88843539	88843562	15	-	27869803	HPAFII	viability after 15 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-0.9817584357475482	[106]	[19,81,NaN]	-7	hSpCas9	negative selection	9637677
88845859	88845882	15	+	27869803	HPAFII	viability after 15 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	-0.1546741407667483	[342]	[213,403,NaN]	-2	hSpCas9	negative selection	9637678
88847352	88847375	15	-	27869803	HPAFII	viability after 15 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	1.2661777312727946	[81]	[227,201,NaN]	9	hSpCas9	negative selection	9637679
88838817	88838840	15	+	27869803	ASPC1	viability after 36 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	0.1898065217018851	[522]	[8,173,372]	1	hSpCas9	negative selection	9720123
88840078	88840101	15	-	27869803	ASPC1	viability after 36 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	-0.647298618341932	[198]	[0,79,45]	-6	hSpCas9	negative selection	9720124
88841756	88841779	15	-	27869803	ASPC1	viability after 36 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	0.09595344865726618	[1410]	[228,482,763]	0	hSpCas9	negative selection	9720125
88843539	88843562	15	-	27869803	ASPC1	viability after 36 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-0.27695425251384065	[233]	[67,29,95]	-3	hSpCas9	negative selection	9720126
88845859	88845882	15	+	27869803	ASPC1	viability after 36 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	-0.5556944915650387	[902]	[461,102,126]	-5	hSpCas9	negative selection	9720127
88847352	88847375	15	-	27869803	ASPC1	viability after 36 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	0.7286367798066173	[306]	[68,412,64]	7	hSpCas9	negative selection	9720128
88838817	88838840	15	+	27869803	PATU8988S	viability after 35 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	0.4187710090162472	[451]	[178,307,NaN]	5	hSpCas9	negative selection	9802572
88840078	88840101	15	-	27869803	PATU8988S	viability after 35 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	-0.18804960616177935	[119]	[8,75,NaN]	-2	hSpCas9	negative selection	9802573
88841756	88841779	15	-	27869803	PATU8988S	viability after 35 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.34871423800447765	[960]	[276,330,NaN]	-4	hSpCas9	negative selection	9802574
88843539	88843562	15	-	27869803	PATU8988S	viability after 35 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-0.23810269851429056	[281]	[6,185,NaN]	-3	hSpCas9	negative selection	9802575
88845859	88845882	15	+	27869803	PATU8988S	viability after 35 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	0.5410393377184884	[754]	[414,469,NaN]	6	hSpCas9	negative selection	9802576
88847352	88847375	15	-	27869803	PATU8988S	viability after 35 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	0.18671538042937996	[206]	[45,143,NaN]	2	hSpCas9	negative selection	9802577
88838817	88838840	15	+	27869803	PATU8988S	viability after 31 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	0.4541520778366865	[451]	[216,284,NaN]	5	hSpCas9	negative selection	9885021
88840078	88840101	15	-	27869803	PATU8988S	viability after 31 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	-0.3725624173235551	[119]	[32,41,NaN]	-4	hSpCas9	negative selection	9885022
88841756	88841779	15	-	27869803	PATU8988S	viability after 31 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.5308675796842823	[960]	[178,374,NaN]	-5	hSpCas9	negative selection	9885023
88843539	88843562	15	-	27869803	PATU8988S	viability after 31 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-0.35912767237764365	[281]	[22,169,NaN]	-4	hSpCas9	negative selection	9885024
88845859	88845882	15	+	27869803	PATU8988S	viability after 31 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	0.27921289405861327	[754]	[246,515,NaN]	3	hSpCas9	negative selection	9885025
88847352	88847375	15	-	27869803	PATU8988S	viability after 31 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	0.5527354001815891	[206]	[95,152,NaN]	6	hSpCas9	negative selection	9885026
88838817	88838840	15	+	27869803	HPAFII	viability after 35 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	-1.7882591452707008	[182]	[23,29,NaN]	-7	hSpCas9	negative selection	9967470
88840078	88840101	15	-	27869803	HPAFII	viability after 35 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	-0.3574732164063028	[67]	[0,55,NaN]	-2	hSpCas9	negative selection	9967471
88841756	88841779	15	-	27869803	HPAFII	viability after 35 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-0.6037381992574791	[494]	[202,121,NaN]	-4	hSpCas9	negative selection	9967472
88843539	88843562	15	-	27869803	HPAFII	viability after 35 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-0.9642948785634238	[106]	[23,31,NaN]	-5	hSpCas9	negative selection	9967473
88845859	88845882	15	+	27869803	HPAFII	viability after 35 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	0.00489954423318667	[342]	[50,312,NaN]	0	hSpCas9	negative selection	9967474
88847352	88847375	15	-	27869803	HPAFII	viability after 35 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	1.0767574376596594	[81]	[32,148,NaN]	7	hSpCas9	negative selection	9967475
88838817	88838840	15	+	27869803	HPAFII	viability after 31 days	GAGCCGTGTGTCCAAGGAGAAGG	ACAN	ENSG00000157766	-1.4474770005456996	[182]	[29,45,NaN]	-7	hSpCas9	negative selection	10049919
88840078	88840101	15	-	27869803	HPAFII	viability after 31 days	GATGGCACTGTTCTGCAGGCAGG	ACAN	ENSG00000157766	-0.5335786362744397	[67]	[0,53,NaN]	-4	hSpCas9	negative selection	10049920
88841756	88841779	15	-	27869803	HPAFII	viability after 31 days	TCTCCATAGCAGCCTTCCCGGGG	ACAN	ENSG00000157766	-1.1070058290448446	[494]	[172,80,NaN]	-6	hSpCas9	negative selection	10049921
88843539	88843562	15	-	27869803	HPAFII	viability after 31 days	GGTTGCCACCGCAGTTGGGCCGG	ACAN	ENSG00000157766	-0.24662305355254244	[106]	[41,59,NaN]	-2	hSpCas9	negative selection	10049922
88845859	88845882	15	+	27869803	HPAFII	viability after 31 days	CTGGGCAGCCGCATTTGCCAGGG	ACAN	ENSG00000157766	-0.09186831524503514	[342]	[93,274,NaN]	0	hSpCas9	negative selection	10049923
88847352	88847375	15	-	27869803	HPAFII	viability after 31 days	AGCCTGCTTCGTAGGCGGCCTGG	ACAN	ENSG00000157766	0.17804136319753372	[81]	[19,86,NaN]	1	hSpCas9	negative selection	10049924
88855141	88855164	15	+	28162770	P31FUJ	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	-1.2642804358875466	[138]	[67]	-7	hSpCas9	negative selection	10105671
88849598	88849621	15	-	28162770	P31FUJ	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	-0.08504858397068671	[101]	[112]	-1	hSpCas9	negative selection	10105672
88838735	88838758	15	-	28162770	P31FUJ	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	0.6755673201200534	[129]	[243]	7	hSpCas9	negative selection	10105673
88838774	88838797	15	-	28162770	P31FUJ	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	1.2977125122844009	[8]	[25]	9	hSpCas9	negative selection	10105674
88838789	88838812	15	-	28162770	P31FUJ	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	-0.010409783077930945	[125]	[146]	0	hSpCas9	negative selection	10105675
88838835	88838858	15	+	28162770	P31FUJ	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	0.2255627265285658	[122]	[168]	2	hSpCas9	negative selection	10105676
88840105	88840128	15	-	28162770	P31FUJ	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	0.675818901782717	[610]	[1146]	7	hSpCas9	negative selection	10105677
88843474	88843497	15	+	28162770	P31FUJ	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	0.276450636482116	[325]	[463]	3	hSpCas9	negative selection	10105678
88843526	88843549	15	-	28162770	P31FUJ	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	-5.847512048529587	[48]	[0]	-9	hSpCas9	negative selection	10105679
88847946	88847969	15	+	28162770	P31FUJ	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	0.23518417481342424	[641]	[887]	2	hSpCas9	negative selection	10105680
88855141	88855164	15	+	28162770	TF1	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	NaN	[NaN]	[68]	1	hSpCas9	negative selection	10275037
88849598	88849621	15	-	28162770	TF1	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	NaN	[NaN]	[98]	1	hSpCas9	negative selection	10275038
88838735	88838758	15	-	28162770	TF1	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	NaN	[NaN]	[173]	1	hSpCas9	negative selection	10275039
88838774	88838797	15	-	28162770	TF1	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	NaN	[NaN]	[0]	1	hSpCas9	negative selection	10275040
88838789	88838812	15	-	28162770	TF1	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	NaN	[NaN]	[92]	1	hSpCas9	negative selection	10275041
88838835	88838858	15	+	28162770	TF1	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	NaN	[NaN]	[54]	1	hSpCas9	negative selection	10275042
88840105	88840128	15	-	28162770	TF1	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	NaN	[NaN]	[626]	1	hSpCas9	negative selection	10275043
88843474	88843497	15	+	28162770	TF1	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	NaN	[NaN]	[227]	1	hSpCas9	negative selection	10275044
88843526	88843549	15	-	28162770	TF1	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	NaN	[NaN]	[0]	1	hSpCas9	negative selection	10275045
88847946	88847969	15	+	28162770	TF1	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	NaN	[NaN]	[937]	1	hSpCas9	negative selection	10275046
88855141	88855164	15	+	28162770	SKM1	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	-0.3563381256731937	[41]	[57]	-3	hSpCas9	negative selection	10444403
88849598	88849621	15	-	28162770	SKM1	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	-1.1301239933843372	[25]	[20]	-7	hSpCas9	negative selection	10444404
88838735	88838758	15	-	28162770	SKM1	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	-0.029806583135407128	[40]	[70]	0	hSpCas9	negative selection	10444405
88838774	88838797	15	-	28162770	SKM1	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	-1.2814333166593026	[10]	[7]	-7	hSpCas9	negative selection	10444406
88838789	88838812	15	-	28162770	SKM1	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	0.5983301009263515	[33]	[90]	6	hSpCas9	negative selection	10444407
88838835	88838858	15	+	28162770	SKM1	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	0.2421286393977101	[43]	[91]	2	hSpCas9	negative selection	10444408
88840105	88840128	15	-	28162770	SKM1	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	0.40039072331444236	[131]	[307]	4	hSpCas9	negative selection	10444409
88843474	88843497	15	+	28162770	SKM1	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	-0.3408750082853892	[47]	[66]	-3	hSpCas9	negative selection	10444410
88843526	88843549	15	-	28162770	SKM1	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	-1.8220016980220048	[1]	[0]	-8	hSpCas9	negative selection	10444411
88847946	88847969	15	+	28162770	SKM1	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	0.11910461292442598	[149]	[287]	1	hSpCas9	negative selection	10444412
88855141	88855164	15	+	28162770	SKM1	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	-0.3563381256731937	[41]	[57]	-3	hSpCas9	negative selection	10613769
88849598	88849621	15	-	28162770	SKM1	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	-1.1301239933843372	[25]	[20]	-7	hSpCas9	negative selection	10613770
88838735	88838758	15	-	28162770	SKM1	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	-0.029806583135407128	[40]	[70]	0	hSpCas9	negative selection	10613771
88838774	88838797	15	-	28162770	SKM1	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	-1.2814333166593026	[10]	[7]	-7	hSpCas9	negative selection	10613772
88838789	88838812	15	-	28162770	SKM1	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	0.5983301009263515	[33]	[90]	6	hSpCas9	negative selection	10613773
88838835	88838858	15	+	28162770	SKM1	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	0.2421286393977101	[43]	[91]	2	hSpCas9	negative selection	10613774
88840105	88840128	15	-	28162770	SKM1	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	0.40039072331444236	[131]	[307]	4	hSpCas9	negative selection	10613775
88843474	88843497	15	+	28162770	SKM1	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	-0.3408750082853892	[47]	[66]	-3	hSpCas9	negative selection	10613776
88843526	88843549	15	-	28162770	SKM1	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	-1.8220016980220048	[1]	[0]	-8	hSpCas9	negative selection	10613777
88847946	88847969	15	+	28162770	SKM1	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	0.11910461292442598	[149]	[287]	1	hSpCas9	negative selection	10613778
88855141	88855164	15	+	28162770	PL21	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	0.22003917192702507	[143]	[72]	2	hSpCas9	negative selection	10783135
88849598	88849621	15	-	28162770	PL21	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	0.6672656249166182	[67]	[46]	6	hSpCas9	negative selection	10783136
88838735	88838758	15	-	28162770	PL21	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	0.41313333782351835	[175]	[101]	3	hSpCas9	negative selection	10783137
88838774	88838797	15	-	28162770	PL21	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	-2.1217884803980427	[9]	[0]	-8	hSpCas9	negative selection	10783138
88838789	88838812	15	-	28162770	PL21	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	0.994464588097806	[142]	[123]	8	hSpCas9	negative selection	10783139
88838835	88838858	15	+	28162770	PL21	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	0.7088915485903577	[148]	[105]	6	hSpCas9	negative selection	10783140
88840105	88840128	15	-	28162770	PL21	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	1.8066889774186219	[397]	[605]	9	hSpCas9	negative selection	10783141
88843474	88843497	15	+	28162770	PL21	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	-0.6513378608005915	[165]	[45]	-4	hSpCas9	negative selection	10783142
88843526	88843549	15	-	28162770	PL21	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	-1.3848228862318361	[5]	[0]	-7	hSpCas9	negative selection	10783143
88847946	88847969	15	+	28162770	PL21	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	0.7251671449562447	[384]	[276]	6	hSpCas9	negative selection	10783144
88855141	88855164	15	+	28162770	P31FUJ	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	-1.2642804358875466	[138]	[67]	-7	hSpCas9	negative selection	10952501
88849598	88849621	15	-	28162770	P31FUJ	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	-0.08504858397068671	[101]	[112]	-1	hSpCas9	negative selection	10952502
88838735	88838758	15	-	28162770	P31FUJ	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	0.6755673201200534	[129]	[243]	7	hSpCas9	negative selection	10952503
88838774	88838797	15	-	28162770	P31FUJ	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	1.2977125122844009	[8]	[25]	9	hSpCas9	negative selection	10952504
88838789	88838812	15	-	28162770	P31FUJ	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	-0.010409783077930945	[125]	[146]	0	hSpCas9	negative selection	10952505
88838835	88838858	15	+	28162770	P31FUJ	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	0.2255627265285658	[122]	[168]	2	hSpCas9	negative selection	10952506
88840105	88840128	15	-	28162770	P31FUJ	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	0.675818901782717	[610]	[1146]	7	hSpCas9	negative selection	10952507
88843474	88843497	15	+	28162770	P31FUJ	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	0.276450636482116	[325]	[463]	3	hSpCas9	negative selection	10952508
88843526	88843549	15	-	28162770	P31FUJ	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	-5.847512048529587	[48]	[0]	-9	hSpCas9	negative selection	10952509
88847946	88847969	15	+	28162770	P31FUJ	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	0.23518417481342424	[641]	[887]	2	hSpCas9	negative selection	10952510
88855141	88855164	15	+	28162770	OCIAML5	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	-2.04708255326914	[86]	[37]	-8	hSpCas9	negative selection	11121867
88849598	88849621	15	-	28162770	OCIAML5	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	-0.6207410247575413	[45]	[53]	-4	hSpCas9	negative selection	11121868
88838735	88838758	15	-	28162770	OCIAML5	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	1.4627194547793456	[80]	[402]	9	hSpCas9	negative selection	11121869
88838774	88838797	15	-	28162770	OCIAML5	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	-2.4370290715851537	[2]	[0]	-8	hSpCas9	negative selection	11121870
88838789	88838812	15	-	28162770	OCIAML5	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	-0.09999408430758239	[56]	[95]	0	hSpCas9	negative selection	11121871
88838835	88838858	15	+	28162770	OCIAML5	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	-0.9311381418551958	[74]	[70]	-5	hSpCas9	negative selection	11121872
88840105	88840128	15	-	28162770	OCIAML5	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	0.2753663484642368	[378]	[827]	2	hSpCas9	negative selection	11121873
88843474	88843497	15	+	28162770	OCIAML5	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	-0.0694583111420784	[167]	[288]	0	hSpCas9	negative selection	11121874
88843526	88843549	15	-	28162770	OCIAML5	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	-1.8520665708639967	[1]	[0]	-7	hSpCas9	negative selection	11121875
88847946	88847969	15	+	28162770	OCIAML5	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	0.8041750862244255	[282]	[891]	7	hSpCas9	negative selection	11121876
88855141	88855164	15	+	28162770	EOL1	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	1.3421870660376582	[276]	[369]	9	hSpCas9	negative selection	11291233
88849598	88849621	15	-	28162770	EOL1	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	-1.8828071504870694	[104]	[14]	-8	hSpCas9	negative selection	11291234
88838735	88838758	15	-	28162770	EOL1	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	0.7615421840680128	[233]	[208]	6	hSpCas9	negative selection	11291235
88838774	88838797	15	-	28162770	EOL1	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	-2.660414729150622	[35]	[2]	-9	hSpCas9	negative selection	11291236
88838789	88838812	15	-	28162770	EOL1	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	0.06541030741038423	[233]	[128]	0	hSpCas9	negative selection	11291237
88838835	88838858	15	+	28162770	EOL1	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	0.4913171555257211	[265]	[196]	4	hSpCas9	negative selection	11291238
88840105	88840128	15	-	28162770	EOL1	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	-0.24921929616617178	[563]	[249]	-2	hSpCas9	negative selection	11291239
88843474	88843497	15	+	28162770	EOL1	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	1.489560682947446	[266]	[394]	9	hSpCas9	negative selection	11291240
88843526	88843549	15	-	28162770	EOL1	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	-2.8828071504870696	[13]	[0]	-9	hSpCas9	negative selection	11291241
88847946	88847969	15	+	28162770	EOL1	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	0.28988694017559125	[693]	[446]	2	hSpCas9	negative selection	11291242
88855141	88855164	15	+	28162770	MOLM13	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	-0.8256103050162661	[200]	[81]	-4	hSpCas9	negative selection	11460599
88849598	88849621	15	-	28162770	MOLM13	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	1.2727590402125888	[82]	[144]	8	hSpCas9	negative selection	11460600
88838735	88838758	15	-	28162770	MOLM13	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	0.11666697986317842	[198]	[155]	0	hSpCas9	negative selection	11460601
88838774	88838797	15	-	28162770	MOLM13	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	-0.4166334010354853	[23]	[12]	-2	hSpCas9	negative selection	11460602
88838789	88838812	15	-	28162770	MOLM13	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	-0.08559488770340945	[203]	[138]	0	hSpCas9	negative selection	11460603
88838835	88838858	15	+	28162770	MOLM13	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	-0.10010004057286381	[168]	[113]	0	hSpCas9	negative selection	11460604
88840105	88840128	15	-	28162770	MOLM13	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	0.047811265565204764	[668]	[499]	0	hSpCas9	negative selection	11460605
88843474	88843497	15	+	28162770	MOLM13	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	0.41089940295974897	[283]	[272]	3	hSpCas9	negative selection	11460606
88843526	88843549	15	-	28162770	MOLM13	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	-4.232550336596514	[25]	[0]	-9	hSpCas9	negative selection	11460607
88847946	88847969	15	+	28162770	MOLM13	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	0.05410042846299401	[769]	[577]	0	hSpCas9	negative selection	11460608
88855141	88855164	15	+	28162770	HEL	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	0.2738715141544392	[163]	[126]	2	hSpCas9	negative selection	11629965
88849598	88849621	15	-	28162770	HEL	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	1.2750070474998698	[59]	[92]	9	hSpCas9	negative selection	11629966
88838735	88838758	15	-	28162770	HEL	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	0.8595502210735052	[184]	[214]	7	hSpCas9	negative selection	11629967
88838774	88838797	15	-	28162770	HEL	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	-2.357261167999643	[15]	[1]	-8	hSpCas9	negative selection	11629968
88838789	88838812	15	-	28162770	HEL	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	0.35390842528922567	[236]	[193]	3	hSpCas9	negative selection	11629969
88838835	88838858	15	+	28162770	HEL	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	0.2991518559832214	[150]	[118]	2	hSpCas9	negative selection	11629970
88840105	88840128	15	-	28162770	HEL	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	0.6029195138869716	[550]	[535]	5	hSpCas9	negative selection	11629971
88843474	88843497	15	+	28162770	HEL	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	-0.8952261891836297	[301]	[103]	-5	hSpCas9	negative selection	11629972
88843526	88843549	15	-	28162770	HEL	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	-1.6791892628870055	[4]	[0]	-7	hSpCas9	negative selection	11629973
88847946	88847969	15	+	28162770	HEL	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	-0.3296929079908386	[621]	[316]	-2	hSpCas9	negative selection	11629974
88855141	88855164	15	+	28162770	MV411	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	-0.5097059253210612	[119]	[70]	-4	hSpCas9	negative selection	11799331
88849598	88849621	15	-	28162770	MV411	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	-3.5599173712748287	[69]	[4]	-9	hSpCas9	negative selection	11799332
88838735	88838758	15	-	28162770	MV411	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	0.35933043085367256	[123]	[133]	3	hSpCas9	negative selection	11799333
88838774	88838797	15	-	28162770	MV411	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	1.0547924728403792	[3]	[6]	8	hSpCas9	negative selection	11799334
88838789	88838812	15	-	28162770	MV411	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	1.0913183488654932	[116]	[209]	8	hSpCas9	negative selection	11799335
88838835	88838858	15	+	28162770	MV411	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	-1.1052340675356949	[165]	[64]	-6	hSpCas9	negative selection	11799336
88840105	88840128	15	-	28162770	MV411	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	0.34117298904864457	[431]	[460]	3	hSpCas9	negative selection	11799337
88843474	88843497	15	+	28162770	MV411	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	0.4033878287444881	[218]	[243]	3	hSpCas9	negative selection	11799338
88843526	88843549	15	-	28162770	MV411	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	-2.9224874506595375	[8]	[0]	-9	hSpCas9	negative selection	11799339
88847946	88847969	15	+	28162770	MV411	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	-0.03316948449896828	[412]	[339]	0	hSpCas9	negative selection	11799340
88855141	88855164	15	+	28162770	MONOMAC1	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	-1.7668924553905017	[94]	[31]	-8	hSpCas9	negative selection	11968697
88849598	88849621	15	-	28162770	MONOMAC1	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	2.521781400396393	[47]	[315]	9	hSpCas9	negative selection	11968698
88838735	88838758	15	-	28162770	MONOMAC1	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	-0.2536203754259212	[77]	[74]	-2	hSpCas9	negative selection	11968699
88838774	88838797	15	-	28162770	MONOMAC1	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	-1.1970368470595538	[7]	[3]	-7	hSpCas9	negative selection	11968700
88838789	88838812	15	-	28162770	MONOMAC1	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	-0.8751087521721914	[95]	[59]	-6	hSpCas9	negative selection	11968701
88838835	88838858	15	+	28162770	MONOMAC1	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	-0.4149418774036875	[106]	[91]	-4	hSpCas9	negative selection	11968702
88840105	88840128	15	-	28162770	MONOMAC1	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	-0.1180289726197632	[301]	[318]	-1	hSpCas9	negative selection	11968703
88843474	88843497	15	+	28162770	MONOMAC1	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	-0.18751407294104697	[150]	[151]	-2	hSpCas9	negative selection	11968704
88843526	88843549	15	-	28162770	MONOMAC1	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	-1.0043917691171576	[6]	[3]	-7	hSpCas9	negative selection	11968705
88847946	88847969	15	+	28162770	MONOMAC1	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	0.3559579250029665	[288]	[423]	3	hSpCas9	negative selection	11968706
88855141	88855164	15	+	28162770	OCIAML2	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	-0.5128580606314586	[25]	[100]	-4	hSpCas9	negative selection	12138063
88849598	88849621	15	-	28162770	OCIAML2	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	-0.20759541940836712	[9]	[47]	-2	hSpCas9	negative selection	12138064
88838735	88838758	15	-	28162770	OCIAML2	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	-1.4132966501762096	[36]	[76]	-7	hSpCas9	negative selection	12138065
88838774	88838797	15	-	28162770	OCIAML2	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	0.3367250968154427	[1]	[13]	3	hSpCas9	negative selection	12138066
88838789	88838812	15	-	28162770	OCIAML2	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	0.21009165828442575	[33]	[217]	2	hSpCas9	negative selection	12138067
88838835	88838858	15	+	28162770	OCIAML2	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	0.018117360219691986	[30]	[173]	0	hSpCas9	negative selection	12138068
88840105	88840128	15	-	28162770	OCIAML2	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	0.5834468475136316	[71]	[597]	5	hSpCas9	negative selection	12138069
88843474	88843497	15	+	28162770	OCIAML2	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	0.4491998260738554	[36]	[279]	4	hSpCas9	negative selection	12138070
88843526	88843549	15	-	28162770	OCIAML2	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	-2.4706298252421615	[0]	[0]	-8	hSpCas9	negative selection	12138071
88847946	88847969	15	+	28162770	OCIAML2	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	0.6168330160081781	[85]	[730]	6	hSpCas9	negative selection	12138072
88855141	88855164	15	+	28162770	OCIAML3	viability	TGAGCTGCCCAGCTCTGGGGAGG	ACAN	ENSG00000157766	-1.525294890240149	[40]	[42]	-8	hSpCas9	negative selection	12307429
88849598	88849621	15	-	28162770	OCIAML3	viability	GGGTGACGATGGGGTAGCGGAGG	ACAN	ENSG00000157766	2.455235878695686	[17]	[297]	9	hSpCas9	negative selection	12307430
88838735	88838758	15	-	28162770	OCIAML3	viability	GTCGATGAAATAGCAGGGGATGG	ACAN	ENSG00000157766	1.2345118917314832	[28]	[205]	8	hSpCas9	negative selection	12307431
88838774	88838797	15	-	28162770	OCIAML3	viability	TGGGGCGGTAGAAGGGGCGGTGG	ACAN	ENSG00000157766	-2.079434467494405	[6]	[4]	-8	hSpCas9	negative selection	12307432
88838789	88838812	15	-	28162770	OCIAML3	viability	GATTCTTGGGGCCAGTGGGGCGG	ACAN	ENSG00000157766	0.618986083010035	[43]	[203]	5	hSpCas9	negative selection	12307433
88838835	88838858	15	+	28162770	OCIAML3	viability	GAAGGAGGTAGTGCTGCTGGTGG	ACAN	ENSG00000157766	-0.9291918319137924	[40]	[64]	-6	hSpCas9	negative selection	12307434
88840105	88840128	15	-	28162770	OCIAML3	viability	GGCCTGCAGCTGCTCAGGCGTGG	ACAN	ENSG00000157766	0.9240238522780058	[124]	[715]	7	hSpCas9	negative selection	12307435
88843474	88843497	15	+	28162770	OCIAML3	viability	GGCATGGACATGTGCAGCGCCGG	ACAN	ENSG00000157766	0.4625758880422043	[49]	[207]	4	hSpCas9	negative selection	12307436
88843526	88843549	15	-	28162770	OCIAML3	viability	GTTGGGCCGGGCCTTGGAGATGG	ACAN	ENSG00000157766	-2.594007640324163	[1]	[0]	-9	hSpCas9	negative selection	12307437
88847946	88847969	15	+	28162770	OCIAML3	viability	GTGACAAGGACAGCAGCCCAGGG	ACAN	ENSG00000157766	0.05635733561863243	[114]	[360]	0	hSpCas9	negative selection	12307438