| 5528378 | 5528401 | 7 | + | 26472758 | Jiyoye | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | -0.7052993477525391 | [79] | [36] | -5 | hSpCas9 | negative selection | 2012 | 5528653 | 5528676 | 7 | + | 26472758 | Jiyoye | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | 0.3796946450837663 | [105] | [103] | 3 | hSpCas9 | negative selection | 2013 | 5529619 | 5529642 | 7 | + | 26472758 | Jiyoye | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | 1.0238467419543675 | [44] | [68] | 6 | hSpCas9 | negative selection | 2014 | 5529160 | 5529183 | 7 | - | 26472758 | Jiyoye | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.7342970444470073 | [363] | [164] | -5 | hSpCas9 | negative selection | 2015 | 5528675 | 5528698 | 7 | + | 26472758 | Jiyoye | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | 0.40717538150587335 | [86] | [86] | 3 | hSpCas9 | negative selection | 2016 | 5528401 | 5528424 | 7 | - | 26472758 | Jiyoye | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | 5.577100382948185 | [0] | [35] | 9 | hSpCas9 | negative selection | 2017 | 5528267 | 5528290 | 7 | + | 26472758 | Jiyoye | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -0.5206748327382914 | [155] | [81] | -4 | hSpCas9 | negative selection | 2018 | 5529525 | 5529548 | 7 | + | 26472758 | Jiyoye | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | -1.2652499604656222 | [101] | [31] | -7 | hSpCas9 | negative selection | 2019 | 5529388 | 5529411 | 7 | - | 26472758 | Jiyoye | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.8658431129005424 | [260] | [107] | -6 | hSpCas9 | negative selection | 2020 | 5529266 | 5529289 | 7 | - | 26472758 | Jiyoye | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | -0.03339720988010787 | [132] | [97] | 0 | hSpCas9 | negative selection | 2021 | 5528378 | 5528401 | 7 | + | 26472758 | KBM7 | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | -2.5925223960322086 | [181,92] | [11,8] | -9 | hSpCas9 | negative selection | 193130 | 5528653 | 5528676 | 7 | + | 26472758 | KBM7 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.4605123668009 | [720,455] | [141,246] | -4 | hSpCas9 | negative selection | 193131 | 5529619 | 5529642 | 7 | + | 26472758 | KBM7 | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -1.3234172918549825 | [589,349] | [134,42] | -7 | hSpCas9 | negative selection | 193132 | 5529160 | 5529183 | 7 | - | 26472758 | KBM7 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -1.8963036242883917 | [1238,837] | [143,115] | -8 | hSpCas9 | negative selection | 193133 | 5528675 | 5528698 | 7 | + | 26472758 | KBM7 | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -2.436412770985255 | [744,739] | [115,18] | -9 | hSpCas9 | negative selection | 193134 | 5528401 | 5528424 | 7 | - | 26472758 | KBM7 | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | -0.7485364733671707 | [182,210] | [68,43] | -6 | hSpCas9 | negative selection | 193135 | 5528267 | 5528290 | 7 | + | 26472758 | KBM7 | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -1.6195584920921562 | [559,559] | [102,70] | -8 | hSpCas9 | negative selection | 193136 | 5529525 | 5529548 | 7 | + | 26472758 | KBM7 | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | -1.938876381503661 | [290,480] | [24,69] | -8 | hSpCas9 | negative selection | 193137 | 5529388 | 5529411 | 7 | - | 26472758 | KBM7 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.8202156266440227 | [708,1157] | [200,304] | -6 | hSpCas9 | negative selection | 193138 | 5529266 | 5529289 | 7 | - | 26472758 | KBM7 | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | -0.3198653547107145 | [462,373] | [152,159] | -3 | hSpCas9 | negative selection | 193139 | 5528378 | 5528401 | 7 | + | 26472758 | Raji | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | 0.20049293976508098 | [44] | [11] | 2 | hSpCas9 | negative selection | 384248 | 5528653 | 5528676 | 7 | + | 26472758 | Raji | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.292547071515036 | [379] | [35] | -7 | hSpCas9 | negative selection | 384249 | 5529619 | 5529642 | 7 | + | 26472758 | Raji | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -1.643937351769677 | [201] | [14] | -8 | hSpCas9 | negative selection | 384250 | 5529160 | 5529183 | 7 | - | 26472758 | Raji | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.8186158831826237 | [417] | [54] | -6 | hSpCas9 | negative selection | 384251 | 5528675 | 5528698 | 7 | + | 26472758 | Raji | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -1.655916206606069 | [257] | [18] | -8 | hSpCas9 | negative selection | 384252 | 5528401 | 5528424 | 7 | - | 26472758 | Raji | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | -0.27404557126242457 | [98] | [18] | -2 | hSpCas9 | negative selection | 384253 | 5528267 | 5528290 | 7 | + | 26472758 | Raji | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -2.214544559513763 | [339] | [16] | -8 | hSpCas9 | negative selection | 384254 | 5529525 | 5529548 | 7 | + | 26472758 | Raji | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | -1.951510153679969 | [149] | [8] | -8 | hSpCas9 | negative selection | 384255 | 5529388 | 5529411 | 7 | - | 26472758 | Raji | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -1.895190408290227 | [560] | [34] | -8 | hSpCas9 | negative selection | 384256 | 5529266 | 5529289 | 7 | - | 26472758 | Raji | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | -0.08609619404760951 | [246] | [53] | 0 | hSpCas9 | negative selection | 384257 | 5528378 | 5528401 | 7 | + | 26472758 | K562 | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | -0.30627387096996306 | [103] | [70] | -2 | hSpCas9 | negative selection | 575366 | 5528653 | 5528676 | 7 | + | 26472758 | K562 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | 0.7872458300903369 | [358] | [522] | 6 | hSpCas9 | negative selection | 575367 | 5529619 | 5529642 | 7 | + | 26472758 | K562 | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | 0.7352590510230529 | [379] | [533] | 6 | hSpCas9 | negative selection | 575368 | 5529160 | 5529183 | 7 | - | 26472758 | K562 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.5999598282705381 | [822] | [1052] | 5 | hSpCas9 | negative selection | 575369 | 5528675 | 5528698 | 7 | + | 26472758 | K562 | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -0.38446301526062526 | [616] | [398] | -3 | hSpCas9 | negative selection | 575370 | 5528401 | 5528424 | 7 | - | 26472758 | K562 | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | 0.17695575988770806 | [196] | [187] | 1 | hSpCas9 | negative selection | 575371 | 5528267 | 5528290 | 7 | + | 26472758 | K562 | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | 0.3349704853740715 | [493] | [525] | 2 | hSpCas9 | negative selection | 575372 | 5529525 | 5529548 | 7 | + | 26472758 | K562 | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | 0.9089325274843625 | [146] | [232] | 7 | hSpCas9 | negative selection | 575373 | 5529388 | 5529411 | 7 | - | 26472758 | K562 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.3528221028331461 | [825] | [545] | -2 | hSpCas9 | negative selection | 575374 | 5529266 | 5529289 | 7 | - | 26472758 | K562 | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | 0.3763304031720278 | [375] | [411] | 3 | hSpCas9 | negative selection | 575375 | 5529620 | 5529643 | 7 | - | 26627737 | DLD1 | viability | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -2.8652957030688566 | [837] | [7,11,79] | -9 | hSpCas9 | negative selection | 836768 | 5529620 | 5529643 | 7 | - | 26627737 | GBM cells | viability after 5 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | 0.08273510244107524 | [286] | [183,141] | 1 | hSpCas9 | negative selection | 919083 | 5529620 | 5529643 | 7 | - | 26627737 | GBM cells | viability after 13 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -1.0276363456691724 | [286] | [82,70] | -8 | hSpCas9 | negative selection | 1001398 | 5529620 | 5529643 | 7 | - | 26627737 | GBM cells | viability after 21 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -1.9547527414191364 | [286] | [34,44] | -8 | hSpCas9 | negative selection | 1083713 | 5529620 | 5529643 | 7 | - | 26627737 | RPE1 | viability after 9 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | 0.8170558066789444 | [1177] | [678,611] | 5 | hSpCas9 | negative selection | 1166028 | 5529620 | 5529643 | 7 | - | 26627737 | RPE1 | viability after 12 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | 1.5648806703841533 | [1177] | [1015,851] | 8 | hSpCas9 | negative selection | 1248343 | 5529620 | 5529643 | 7 | - | 26627737 | RPE1 | viability after 15 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | 1.7847537307907062 | [1177] | [1531,777] | 8 | hSpCas9 | negative selection | 1330658 | 5529620 | 5529643 | 7 | - | 26627737 | RPE1 | viability after 18 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | 2.0939308208699856 | [1177] | [1434,1273] | 8 | hSpCas9 | negative selection | 1412973 | 5529620 | 5529643 | 7 | - | 26627737 | HeLa | viability after 8 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -0.47106270677003814 | [564] | [218,66,249] | -4 | hSpCas9 | negative selection | 1495288 | 5529620 | 5529643 | 7 | - | 26627737 | HeLa | viability after 12 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | 0.1592682984624446 | [564] | [272,105,419] | 1 | hSpCas9 | negative selection | 1577603 | 5529620 | 5529643 | 7 | - | 26627737 | HeLa | viability after 15 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | 0.1309810638456611 | [564] | [157,199,410] | 1 | hSpCas9 | negative selection | 1659918 | 5529620 | 5529643 | 7 | - | 26627737 | HeLa | viability after 18 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | 0.1476776583081426 | [564] | [108,168,410] | 1 | hSpCas9 | negative selection | 1742233 | 5529620 | 5529643 | 7 | - | 26627737 | HCT116 | viability after 6 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | 0.5450962108676138 | [1174] | [177,319] | 3 | hSpCas9 | negative selection | 1824548 | 5529620 | 5529643 | 7 | - | 26627737 | HCT116 | viability after 8 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -0.17641702978927365 | [620] | [266,274,364] | -2 | hSpCas9 | negative selection | 1906863 | 5529620 | 5529643 | 7 | - | 26627737 | HCT116 | viability after 9 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | 0.181438246257833 | [1174] | [352,357] | 1 | hSpCas9 | negative selection | 1989178 | 5529620 | 5529643 | 7 | - | 26627737 | HCT116 | viability after 12 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -0.3579243791282518 | [620] | [252,250,259] | -4 | hSpCas9 | negative selection | 2071493 | 5529620 | 5529643 | 7 | - | 26627737 | HCT116 | viability after 15 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -0.21568141031993837 | [620] | [356,311,258] | -2 | hSpCas9 | negative selection | 2153808 | 5529620 | 5529643 | 7 | - | 26627737 | HCT116 | viability after 18 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -0.3735531564967576 | [620] | [208,259,223] | -3 | hSpCas9 | negative selection | 2236123 | 5553676 | 5553699 | 7 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TGTAATCCCAGCACTTCGGGAAG | ACTB | ENSG00000075624 | -3.9690945324429574 | [10,229] | [0,1] | -9 | dCas9-VP64 | positive selection | 2383096 | 5542357 | 5542380 | 7 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAGGCTTGAGCCACTGCGCCCGG | ACTB | ENSG00000075624 | 1.5878752533514864 | [74,11] | [3,54] | 6 | dCas9-VP64 | positive selection | 2388869 | 5530773 | 5530796 | 7 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | AAAGAGCGAGAGCGAGATTGAGG | ACTB | ENSG00000075624 | -2.0167080468273566 | [42,14] | [0,1] | -9 | dCas9-VP64 | positive selection | 2396217 | 5530711 | 5530734 | 7 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GCTGCACTGTGCGGCGAAGCCGG | ACTB | ENSG00000075624 | 0.07471986021677246 | [16,27] | [5,2] | 0 | dCas9-VP64 | positive selection | 2396218 | 5530743 | 5530766 | 7 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TCGCAAAAGGAGGGGAGAGGGGG | ACTB | ENSG00000075624 | -0.4835611520715055 | [12,1] | [0,0] | -2 | dCas9-VP64 | positive selection | 2396219 | 5544299 | 5544322 | 7 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TTTCACCGTGTTAGCCAGGAGGG | ACTB | ENSG00000075624 | 0.2955844688889684 | [184,570] | [130,72] | 1 | dCas9-VP64 | positive selection | 2398503 | 5540346 | 5540369 | 7 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAAAAATTAGCTGGGCGTGGCGG | ACTB | ENSG00000075624 | -0.7800023955638035 | [210,54] | [8,23] | -4 | dCas9-VP64 | positive selection | 2414247 | 5548312 | 5548335 | 7 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TCACTGCAACCTCCACCTCCAAG | ACTB | ENSG00000075624 | 0.058421953785092295 | [801,622] | [115,212] | 0 | dCas9-VP64 | positive selection | 2420274 | 5548313 | 5548336 | 7 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CACTGCAACCTCCACCTCCAAGG | ACTB | ENSG00000075624 | -1.6046460755717478 | [271,391] | [12,34] | -8 | dCas9-VP64 | positive selection | 2428029 | 5542133 | 5542156 | 7 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GGAGTGCAGTGGCGCGATCTAGG | ACTB | ENSG00000075624 | -0.31087835177106626 | [209,343] | [40,56] | -1 | dCas9-VP64 | positive selection | 2443280 | 5553676 | 5553699 | 7 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TGTAATCCCAGCACTTCGGGAAG | ACTB | ENSG00000075624 | -1.0802329755633977 | [58,72] | [5,12] | -9 | dCas9-VP64 | positive selection | 2478351 | 5542357 | 5542380 | 7 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAGGCTTGAGCCACTGCGCCCGG | ACTB | ENSG00000075624 | 0.16456713163057946 | [58,38] | [18,15] | 1 | dCas9-VP64 | positive selection | 2484124 | 5530773 | 5530796 | 7 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | AAAGAGCGAGAGCGAGATTGAGG | ACTB | ENSG00000075624 | 0.28368676140526905 | [48,64] | [27,16] | 2 | dCas9-VP64 | positive selection | 2491472 | 5530711 | 5530734 | 7 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GCTGCACTGTGCGGCGAAGCCGG | ACTB | ENSG00000075624 | 0.4281426826881811 | [46,57] | [10,32] | 3 | dCas9-VP64 | positive selection | 2491473 | 5530743 | 5530766 | 7 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TCGCAAAAGGAGGGGAGAGGGGG | ACTB | ENSG00000075624 | 0.050660947140021895 | [77,64] | [18,28] | 0 | dCas9-VP64 | positive selection | 2491474 | 5544299 | 5544322 | 7 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TTTCACCGTGTTAGCCAGGAGGG | ACTB | ENSG00000075624 | 1.071805523628855 | [383,191] | [227,172] | 7 | dCas9-VP64 | positive selection | 2493758 | 5540346 | 5540369 | 7 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAAAAATTAGCTGGGCGTGGCGG | ACTB | ENSG00000075624 | 7.182660032259671 | [52,50] | [5183,10] | 9 | dCas9-VP64 | positive selection | 2509502 | 5548312 | 5548335 | 7 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TCACTGCAACCTCCACCTCCAAG | ACTB | ENSG00000075624 | 0.1281772646791315 | [789,694] | [166,357] | 1 | dCas9-VP64 | positive selection | 2515529 | 5548313 | 5548336 | 7 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CACTGCAACCTCCACCTCCAAGG | ACTB | ENSG00000075624 | 1.7619180919574486 | [222,108] | [343,36] | 8 | dCas9-VP64 | positive selection | 2523284 | 5542133 | 5542156 | 7 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GGAGTGCAGTGGCGCGATCTAGG | ACTB | ENSG00000075624 | 0.057156110736217514 | [593,444] | [221,134] | 0 | dCas9-VP64 | positive selection | 2538535 | 5528579 | 5528602 | 7 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | ACACTGTGCCCATCTACGAGGGG | ACTB | ENSG00000075624 | 0.4435089672793606 | [2,1] | [2,2] | 8 | hSpCas9 | positive selection | 2968678 | 5528676 | 5528699 | 7 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -0.7555017515491211 | [2,3] | [1,1] | -8 | hSpCas9 | positive selection | 2968679 | 5529620 | 5529643 | 7 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -0.4515280594503061 | [4,3] | [4,0] | -6 | hSpCas9 | positive selection | 2968680 | 5529620 | 5529643 | 7 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | 0.0475478203640171 | [3,3] | [3,2] | 1 | hSpCas9 | positive selection | 2968681 | 5528579 | 5528602 | 7 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | ACACTGTGCCCATCTACGAGGGG | ACTB | ENSG00000075624 | -0.8645363136201577 | [2,2] | [0,0] | -9 | hSpCas9 | positive selection | 3036536 | 5528676 | 5528699 | 7 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | 0.27095460731907905 | [2,2] | [2,2] | 5 | hSpCas9 | positive selection | 3036537 | 5529620 | 5529643 | 7 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -0.7354067221240133 | [4,4] | [2,0] | -8 | hSpCas9 | positive selection | 3036538 | 5529620 | 5529643 | 7 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -0.6117590015299984 | [3,3] | [0,1] | -8 | hSpCas9 | positive selection | 3036539 | 5528671 | 5528694 | | - | 24336571 | A375 | resistance to PLX after 7 days | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | 0.14360835776886116 | [35,30] | [33,39] | 4 | hSpCas9 | positive selection | 3159627 | 5529160 | 5529183 | | - | 24336571 | A375 | resistance to PLX after 7 days | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.47510028002350424 | [5,5] | [6,8] | 9 | hSpCas9 | positive selection | 3159634 | 5528653 | 5528676 | | + | 24336571 | A375 | resistance to PLX after 7 days | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | 0.2703371157400716 | [8,8] | [11,9] | 7 | hSpCas9 | positive selection | 3159645 | 5528671 | 5528694 | | - | 24336571 | A375 | resistance to PLX after 14 days | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | 0.03879612854327186 | [32,24] | [13,12] | 0 | hSpCas9 | positive selection | 3217420 | 5529160 | 5529183 | | - | 24336571 | A375 | resistance to PLX after 14 days | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 1.630198584098141 | [2,4] | [5,5] | 9 | hSpCas9 | positive selection | 3217427 | 5528653 | 5528676 | | + | 24336571 | A375 | resistance to PLX after 14 days | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | 1.2830442434306502 | [6,6] | [6,9] | 8 | hSpCas9 | positive selection | 3217438 | 5528671 | 5528694 | | - | 24336571 | A375 | viability after 7 days | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | 0.08344863102953881 | [33] | [35,30] | 1 | hSpCas9 | negative selection | 3275213 | 5529160 | 5529183 | | - | 24336571 | A375 | viability after 7 days | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.3051801761092843 | [4] | [5,5] | 4 | hSpCas9 | negative selection | 3275220 | 5528653 | 5528676 | | + | 24336571 | A375 | viability after 7 days | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.2257117939520232 | [10] | [8,8] | -3 | hSpCas9 | negative selection | 3275231 | 5528671 | 5528694 | | - | 24336571 | A375 | viability after 14 days | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.12179322353521349 | [33] | [32,24] | -1 | hSpCas9 | negative selection | 3333006 | 5529160 | 5529183 | | - | 24336571 | A375 | viability after 14 days | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.20909430867383438 | [4] | [2,4] | -2 | hSpCas9 | negative selection | 3333013 | 5528653 | 5528676 | | + | 24336571 | A375 | viability after 14 days | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.5374207290590265 | [10] | [6,6] | -6 | hSpCas9 | negative selection | 3333024 | 5529160 | 5529183 | 7 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 2.167369514706938 | [42,24] | [0,0] | 7 | hSpCas9 | positive selection | 3335388 | 5529388 | 5529411 | 7 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | 2.4992990017517993 | [35,17] | [0,0] | 8 | hSpCas9 | positive selection | 3335389 | 5528671 | 5528694 | 7 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -1.1769422377864183 | [831,897] | [0,3] | -7 | hSpCas9 | positive selection | 3335390 | 5528653 | 5528676 | 7 | + | 27383988 | 293T | resistance to West Nile virus (flavivirus) | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | 1.0675016525658179 | [72,72] | [0,0] | 5 | hSpCas9 | positive selection | 3354638 | 5528001 | 5528024 | 7 | + | 27383988 | 293T | resistance to West Nile virus (flavivirus) | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | -1.3647256080105412 | [393,393] | [0,0] | -8 | hSpCas9 | positive selection | 3354639 | 5528579 | 5528602 | 7 | - | 26780180 | HT29 | viability (Avana library 4 designs) | ACACTGTGCCCATCTACGAGGGG | ACTB | ENSG00000075624 | 3.75932900735996 | [] | [] | 9 | hSpCas9 | negative selection | 3404626 | 5528675 | 5528698 | 7 | + | 26780180 | HT29 | viability (Avana library 4 designs) | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | 2.21253337001492 | [] | [] | 7 | hSpCas9 | negative selection | 3404627 | 5529620 | 5529643 | 7 | - | 26780180 | HT29 | viability (Avana library 4 designs) | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | 1.79487439349157 | [] | [] | 6 | hSpCas9 | negative selection | 3404628 | 5529619 | 5529642 | 7 | + | 26780180 | HT29 | viability (Avana library 4 designs) | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | 1.1304733535839 | [] | [] | 4 | hSpCas9 | negative selection | 3404629 | 5529619 | 5529642 | 7 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | 5.28397203953673 | [] | [] | 8 | hSpCas9 | negative selection | 3476255 | 5528579 | 5528602 | 7 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | ACACTGTGCCCATCTACGAGGGG | ACTB | ENSG00000075624 | -0.538550903425324 | [] | [] | 0 | hSpCas9 | negative selection | 3476256 | 5529620 | 5529643 | 7 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | 2.18449110720349 | [] | [] | 3 | hSpCas9 | negative selection | 3476257 | 5528675 | 5528698 | 7 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -0.48297619313456 | [] | [] | 0 | hSpCas9 | negative selection | 3476258 | 5529352 | 5529375 | 7 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GGATTCCTATGTGGGCGACGAGG | ACTB | ENSG00000075624 | -6.29713048847482 | [] | [] | -6 | hSpCas9 | negative selection | 3476259 | 5528618 | 5528641 | 7 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GGAGTCCATCACGATGCCAGTGG | ACTB | ENSG00000075624 | -9.24074970574794 | [] | [] | -7 | hSpCas9 | negative selection | 3476260 | 5529619 | 5529642 | 7 | + | 26780180 | A375 | viability (Avana lentiGuide) | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | 1.89808828380298 | [] | [] | 2 | hSpCas9 | negative selection | 3584914 | 5528579 | 5528602 | 7 | - | 26780180 | A375 | viability (Avana lentiGuide) | ACACTGTGCCCATCTACGAGGGG | ACTB | ENSG00000075624 | 22.5511515949443 | [] | [] | 9 | hSpCas9 | negative selection | 3584915 | 5529620 | 5529643 | 7 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | 10.0605189984134 | [] | [] | 7 | hSpCas9 | negative selection | 3584916 | 5528675 | 5528698 | 7 | + | 26780180 | A375 | viability (Avana lentiGuide) | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | 23.5263225118888 | [] | [] | 9 | hSpCas9 | negative selection | 3584917 | 5529352 | 5529375 | 7 | - | 26780180 | A375 | viability (Avana lentiGuide) | GGATTCCTATGTGGGCGACGAGG | ACTB | ENSG00000075624 | 26.2662931262683 | [] | [] | 9 | hSpCas9 | negative selection | 3584918 | 5528618 | 5528641 | 7 | + | 26780180 | A375 | viability (Avana lentiGuide) | GGAGTCCATCACGATGCCAGTGG | ACTB | ENSG00000075624 | 24.9609968004269 | [] | [] | 9 | hSpCas9 | negative selection | 3584919 | 5529619 | 5529642 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | 0.31634750736249456 | [4] | [5,4] | 8 | hSpCas9 | positive selection | 3693573 | 5528579 | 5528602 | 7 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | ACACTGTGCCCATCTACGAGGGG | ACTB | ENSG00000075624 | -0.11243905604627577 | [4] | [4,3] | -2 | hSpCas9 | positive selection | 3693574 | 5529620 | 5529643 | 7 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | 0.2723349216003103 | [5] | [6,5] | 7 | hSpCas9 | positive selection | 3693575 | 5528675 | 5528698 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | 0.3855210145175041 | [5] | [5,7] | 9 | hSpCas9 | positive selection | 3693576 | 5529352 | 5529375 | 7 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GGATTCCTATGTGGGCGACGAGG | ACTB | ENSG00000075624 | -0.010682202489880971 | [6] | [6,5] | 0 | hSpCas9 | positive selection | 3693577 | 5528618 | 5528641 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GGAGTCCATCACGATGCCAGTGG | ACTB | ENSG00000075624 | -0.8815388688443934 | [4] | [1,2] | -8 | hSpCas9 | positive selection | 3693578 | 5529619 | 5529642 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -0.1334548810373446 | [5] | [2,4] | -2 | hSpCas9 | positive selection | 3802180 | 5528579 | 5528602 | 7 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | ACACTGTGCCCATCTACGAGGGG | ACTB | ENSG00000075624 | -1.364911863777001 | [4] | [0,1] | -9 | hSpCas9 | positive selection | 3802181 | 5529620 | 5529643 | 7 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | 0.19971433198698235 | [5] | [6,5] | 5 | hSpCas9 | positive selection | 3802182 | 5528675 | 5528698 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -0.26172017592728997 | [6] | [3,4] | -4 | hSpCas9 | positive selection | 3802183 | 5529352 | 5529375 | 7 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GGATTCCTATGTGGGCGACGAGG | ACTB | ENSG00000075624 | -0.5226587314938115 | [6] | [3,3] | -6 | hSpCas9 | positive selection | 3802184 | 5528618 | 5528641 | 7 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GGAGTCCATCACGATGCCAGTGG | ACTB | ENSG00000075624 | -1.8081681181393539 | [5] | [0,0] | -9 | hSpCas9 | positive selection | 3802185 | 5528671 | 5528694 | 7 | - | 26780180 | A375 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | 1.84754149293166 | [] | [] | 9 | hSpCas9 | negative selection | 3910791 | 5529160 | 5529183 | 7 | - | 26780180 | A375 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.87510811925487 | [] | [] | 3 | hSpCas9 | negative selection | 3910792 | 5528001 | 5528024 | 7 | + | 26780180 | A375 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 1.84866531158482 | [] | [] | 9 | hSpCas9 | negative selection | 3910793 | 5528653 | 5528676 | 7 | + | 26780180 | A375 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | 1.37774513399053 | [] | [] | 7 | hSpCas9 | negative selection | 3910794 | 5529388 | 5529411 | 7 | - | 26780180 | A375 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | 1.50261708040058 | [] | [] | 8 | hSpCas9 | negative selection | 3910795 | 5528671 | 5528694 | 7 | - | 26780180 | HT29 | viability (GeCKOv2 library) | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | 0.804622574993923 | [] | [] | 3 | hSpCas9 | negative selection | 4018757 | 5529160 | 5529183 | 7 | - | 26780180 | HT29 | viability (GeCKOv2 library) | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.926823017343309 | [] | [] | 4 | hSpCas9 | negative selection | 4018758 | 5528001 | 5528024 | 7 | + | 26780180 | HT29 | viability (GeCKOv2 library) | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 1.38193894967643 | [] | [] | 7 | hSpCas9 | negative selection | 4018759 | 5528653 | 5528676 | 7 | + | 26780180 | HT29 | viability (GeCKOv2 library) | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | 1.79041786307021 | [] | [] | 8 | hSpCas9 | negative selection | 4018760 | 5529388 | 5529411 | 7 | - | 26780180 | HT29 | viability (GeCKOv2 library) | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | 1.42098725575709 | [] | [] | 7 | hSpCas9 | negative selection | 4018761 | 5528671 | 5528694 | 7 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | 0.06590954807745936 | [4] | [3,3] | 1 | hSpCas9 | positive selection | 4187515 | 5529160 | 5529183 | 7 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.2092324888128822 | [3] | [2,2] | 5 | hSpCas9 | positive selection | 4187526 | 5528653 | 5528676 | 7 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | 0.13734289889552292 | [3] | [2,2] | 3 | hSpCas9 | positive selection | 4187537 | 5528671 | 5528694 | 7 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.3669326572968422 | [4] | [1,2,1,0] | -5 | hSpCas9 | positive selection | 4251537 | 5529160 | 5529183 | 7 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.0026881205357156546 | [2] | [2,0,0,0] | 0 | hSpCas9 | positive selection | 4251548 | 5528653 | 5528676 | 7 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | 0.9110283335135652 | [2] | [1,0,0,3] | 6 | hSpCas9 | positive selection | 4251559 | 5529160 | 5529183 | 7 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.3346349937592019 | [1] | [1,0] | -6 | hSpCas9 | positive selection | 4254305 | 5529388 | 5529411 | 7 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.04716133518022081 | [2] | [1,1] | -1 | hSpCas9 | positive selection | 4254306 | 5528671 | 5528694 | 7 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | 0.014545312674936528 | [5] | [4,4] | 0 | hSpCas9 | positive selection | 4254307 | 5528653 | 5528676 | 7 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.7189525527416336 | [1] | [0,0] | -9 | hSpCas9 | positive selection | 4318588 | 5528001 | 5528024 | 7 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | -0.4651945332900126 | [3] | [3,0] | -7 | hSpCas9 | positive selection | 4318589 | 5528609 | 5528631 | 7 | - | 27760321 | OCIAML3 | viability | CGTGATGGACTCCGGTGACGGG | ACTB | ENSG00000075624 | -0.9059489511689092 | [598,553] | [178,320] | -7 | hSpCas9 | negative selection | 4375847 | 5529160 | 5529182 | 7 | - | 27760321 | OCIAML3 | viability | AACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.6764725974063752 | [291,216] | [99,153] | -6 | hSpCas9 | negative selection | 4375848 | 5529387 | 5529409 | 7 | - | 27760321 | OCIAML3 | viability | CTTCCCAGGGCGTGATGGTGGG | ACTB | ENSG00000075624 | -0.5508260353865276 | [606,509] | [283,313] | -5 | hSpCas9 | negative selection | 4375849 | 5529542 | 5529564 | 7 | + | 27760321 | OCIAML3 | viability | CTGGGGCGCCCCACGATGGAGG | ACTB | ENSG00000075624 | -0.9745345793856601 | [554,496] | [156,276] | -7 | hSpCas9 | negative selection | 4375850 | 5528609 | 5528631 | 7 | - | 27760321 | OCIAML2 | viability | CGTGATGGACTCCGGTGACGGG | ACTB | ENSG00000075624 | -0.13898660001281377 | [598,553] | [423,422] | -2 | hSpCas9 | negative selection | 4459310 | 5529160 | 5529182 | 7 | - | 27760321 | OCIAML2 | viability | AACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.39893885911720495 | [291,216] | [146,164] | -5 | hSpCas9 | negative selection | 4459311 | 5529387 | 5529409 | 7 | - | 27760321 | OCIAML2 | viability | CTTCCCAGGGCGTGATGGTGGG | ACTB | ENSG00000075624 | -1.0319892500156989 | [606,509] | [163,293] | -7 | hSpCas9 | negative selection | 4459312 | 5529542 | 5529564 | 7 | + | 27760321 | OCIAML2 | viability | CTGGGGCGCCCCACGATGGAGG | ACTB | ENSG00000075624 | -1.08645818593598 | [554,496] | [159,252] | -7 | hSpCas9 | negative selection | 4459313 | 5528609 | 5528631 | 7 | - | 27760321 | MV411 | viability | CGTGATGGACTCCGGTGACGGG | ACTB | ENSG00000075624 | -0.20003061486542661 | [598,553] | [337,320] | -1 | hSpCas9 | negative selection | 4542773 | 5529160 | 5529182 | 7 | - | 27760321 | MV411 | viability | AACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.3378562062833099 | [291,216] | [22,294] | -2 | hSpCas9 | negative selection | 4542774 | 5529387 | 5529409 | 7 | - | 27760321 | MV411 | viability | CTTCCCAGGGCGTGATGGTGGG | ACTB | ENSG00000075624 | -1.3574317332338177 | [606,509] | [4,350] | -7 | hSpCas9 | negative selection | 4542775 | 5529542 | 5529564 | 7 | + | 27760321 | MV411 | viability | CTGGGGCGCCCCACGATGGAGG | ACTB | ENSG00000075624 | -2.3761875789627083 | [554,496] | [37,109] | -8 | hSpCas9 | negative selection | 4542776 | 5528609 | 5528631 | 7 | - | 27760321 | HL60 | viability | CGTGATGGACTCCGGTGACGGG | ACTB | ENSG00000075624 | -1.3976932108992437 | [598,553] | [186,169] | -8 | hSpCas9 | negative selection | 4626236 | 5529160 | 5529182 | 7 | - | 27760321 | HL60 | viability | AACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -2.1255652555982962 | [291,216] | [37,56] | -9 | hSpCas9 | negative selection | 4626237 | 5529387 | 5529409 | 7 | - | 27760321 | HL60 | viability | CTTCCCAGGGCGTGATGGTGGG | ACTB | ENSG00000075624 | -2.531007133073097 | [606,509] | [82,73] | -9 | hSpCas9 | negative selection | 4626238 | 5529542 | 5529564 | 7 | + | 27760321 | HL60 | viability | CTGGGGCGCCCCACGATGGAGG | ACTB | ENSG00000075624 | -1.9330132150241355 | [554,496] | [91,133] | -9 | hSpCas9 | negative selection | 4626239 | 5528609 | 5528631 | 7 | - | 27760321 | HT1080 | viability | CGTGATGGACTCCGGTGACGGG | ACTB | ENSG00000075624 | -2.6179616826379615 | [553,432] | [0,65] | -7 | hSpCas9 | negative selection | 4709699 | 5529160 | 5529182 | 7 | - | 27760321 | HT1080 | viability | AACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -2.3270532241485267 | [216,169] | [1,29] | -6 | hSpCas9 | negative selection | 4709700 | 5529387 | 5529409 | 7 | - | 27760321 | HT1080 | viability | CTTCCCAGGGCGTGATGGTGGG | ACTB | ENSG00000075624 | -1.9200580034244088 | [509,397] | [74,17] | -6 | hSpCas9 | negative selection | 4709701 | 5529542 | 5529564 | 7 | + | 27760321 | HT1080 | viability | CTGGGGCGCCCCACGATGGAGG | ACTB | ENSG00000075624 | -7.461741823277593 | [496,387] | [0,0] | -9 | hSpCas9 | negative selection | 4709702 | 5528609 | 5528631 | 7 | - | 27760321 | HT29 | viability after 7 days | CGTGATGGACTCCGGTGACGGG | ACTB | ENSG00000075624 | 0.29674152419169164 | [553,432] | [804,504,1022] | 4 | hSpCas9 | negative selection | 4793162 | 5529160 | 5529182 | 7 | - | 27760321 | HT29 | viability after 7 days | AACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.6548609583114691 | [216,169] | [308,588,268] | 8 | hSpCas9 | negative selection | 4793163 | 5529387 | 5529409 | 7 | - | 27760321 | HT29 | viability after 7 days | CTTCCCAGGGCGTGATGGTGGG | ACTB | ENSG00000075624 | -0.020823122374628134 | [509,397] | [513,707,496] | 0 | hSpCas9 | negative selection | 4793164 | 5529542 | 5529564 | 7 | + | 27760321 | HT29 | viability after 7 days | CTGGGGCGCCCCACGATGGAGG | ACTB | ENSG00000075624 | -0.20336056499051772 | [496,387] | [601,493,403] | -3 | hSpCas9 | negative selection | 4793165 | 5528609 | 5528631 | 7 | - | 27760321 | HT29 | viability after 25 days | CGTGATGGACTCCGGTGACGGG | ACTB | ENSG00000075624 | -0.284583205087967 | [553,432] | [577,324,479] | -3 | hSpCas9 | negative selection | 4876625 | 5529160 | 5529182 | 7 | - | 27760321 | HT29 | viability after 25 days | AACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.22447122046843704 | [216,169] | [146,210,214] | -2 | hSpCas9 | negative selection | 4876626 | 5529387 | 5529409 | 7 | - | 27760321 | HT29 | viability after 25 days | CTTCCCAGGGCGTGATGGTGGG | ACTB | ENSG00000075624 | -1.0445102174961274 | [509,397] | [207,279,270] | -6 | hSpCas9 | negative selection | 4876627 | 5529542 | 5529564 | 7 | + | 27760321 | HT29 | viability after 25 days | CTGGGGCGCCCCACGATGGAGG | ACTB | ENSG00000075624 | -2.2371115755888065 | [496,387] | [50,133,143] | -8 | hSpCas9 | negative selection | 4876628 | 5528609 | 5528631 | 7 | - | 27760321 | HT29 | viability after 22 days | CGTGATGGACTCCGGTGACGGG | ACTB | ENSG00000075624 | -0.19586170337168796 | [553,432] | [702,269,515] | -2 | hSpCas9 | negative selection | 4960088 | 5529160 | 5529182 | 7 | - | 27760321 | HT29 | viability after 22 days | AACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.2421061226268627 | [216,169] | [259,269,263] | 2 | hSpCas9 | negative selection | 4960089 | 5529387 | 5529409 | 7 | - | 27760321 | HT29 | viability after 22 days | CTTCCCAGGGCGTGATGGTGGG | ACTB | ENSG00000075624 | -1.3198887357722753 | [509,397] | [147,208,275] | -7 | hSpCas9 | negative selection | 4960090 | 5529542 | 5529564 | 7 | + | 27760321 | HT29 | viability after 22 days | CTGGGGCGCCCCACGATGGAGG | ACTB | ENSG00000075624 | -1.6129226113537307 | [496,387] | [186,167,145] | -7 | hSpCas9 | negative selection | 4960091 | 5528609 | 5528631 | 7 | - | 27760321 | HT29 | viability after 19 days | CGTGATGGACTCCGGTGACGGG | ACTB | ENSG00000075624 | -0.4971914051655957 | [553,432] | [453,240,505] | -4 | hSpCas9 | negative selection | 5043551 | 5529160 | 5529182 | 7 | - | 27760321 | HT29 | viability after 19 days | AACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.4244854530412762 | [216,169] | [195,428,256] | 4 | hSpCas9 | negative selection | 5043552 | 5529387 | 5529409 | 7 | - | 27760321 | HT29 | viability after 19 days | CTTCCCAGGGCGTGATGGTGGG | ACTB | ENSG00000075624 | -1.0386584428635128 | [509,397] | [334,240,192] | -6 | hSpCas9 | negative selection | 5043553 | 5529542 | 5529564 | 7 | + | 27760321 | HT29 | viability after 19 days | CTGGGGCGCCCCACGATGGAGG | ACTB | ENSG00000075624 | -1.9393473565585635 | [496,387] | [143,146,106] | -8 | hSpCas9 | negative selection | 5043554 | 5528609 | 5528631 | 7 | - | 27760321 | HT29 | viability after 16 days | CGTGATGGACTCCGGTGACGGG | ACTB | ENSG00000075624 | -0.1837345348894966 | [553,432] | [502,254,707] | -2 | hSpCas9 | negative selection | 5127014 | 5529160 | 5529182 | 7 | - | 27760321 | HT29 | viability after 16 days | AACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.22709704915520235 | [216,169] | [368,121,82] | -3 | hSpCas9 | negative selection | 5127015 | 5529387 | 5529409 | 7 | - | 27760321 | HT29 | viability after 16 days | CTTCCCAGGGCGTGATGGTGGG | ACTB | ENSG00000075624 | -0.8667995208626964 | [509,397] | [265,215,353] | -6 | hSpCas9 | negative selection | 5127016 | 5529542 | 5529564 | 7 | + | 27760321 | HT29 | viability after 16 days | CTGGGGCGCCCCACGATGGAGG | ACTB | ENSG00000075624 | -1.0914742353304077 | [496,387] | [125,228,331] | -7 | hSpCas9 | negative selection | 5127017 | 5528609 | 5528631 | 7 | - | 27760321 | HT29 | viability after 13 days | CGTGATGGACTCCGGTGACGGG | ACTB | ENSG00000075624 | 0.27290580681102916 | [553,432] | [743,551,773] | 3 | hSpCas9 | negative selection | 5210477 | 5529160 | 5529182 | 7 | - | 27760321 | HT29 | viability after 13 days | AACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.6662303840582882 | [216,169] | [337,409,322] | 8 | hSpCas9 | negative selection | 5210478 | 5529387 | 5529409 | 7 | - | 27760321 | HT29 | viability after 13 days | CTTCCCAGGGCGTGATGGTGGG | ACTB | ENSG00000075624 | -0.5007459782966495 | [509,397] | [472,417,233] | -5 | hSpCas9 | negative selection | 5210479 | 5529542 | 5529564 | 7 | + | 27760321 | HT29 | viability after 13 days | CTGGGGCGCCCCACGATGGAGG | ACTB | ENSG00000075624 | -0.5449534549177801 | [496,387] | [257,296,491] | -6 | hSpCas9 | negative selection | 5210480 | 5528609 | 5528631 | 7 | - | 27760321 | HT29 | viability after 10 days | CGTGATGGACTCCGGTGACGGG | ACTB | ENSG00000075624 | 0.06358237248634846 | [553,432] | [537,874,527] | 0 | hSpCas9 | negative selection | 5293940 | 5529160 | 5529182 | 7 | - | 27760321 | HT29 | viability after 10 days | AACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.5232892036378272 | [216,169] | [221,405,413] | 7 | hSpCas9 | negative selection | 5293941 | 5529387 | 5529409 | 7 | - | 27760321 | HT29 | viability after 10 days | CTTCCCAGGGCGTGATGGTGGG | ACTB | ENSG00000075624 | -0.050025674538906606 | [509,397] | [500,658,486] | 0 | hSpCas9 | negative selection | 5293942 | 5529542 | 5529564 | 7 | + | 27760321 | HT29 | viability after 10 days | CTGGGGCGCCCCACGATGGAGG | ACTB | ENSG00000075624 | -0.7566426166561032 | [496,387] | [309,194,468] | -7 | hSpCas9 | negative selection | 5293943 | 5528609 | 5528631 | 7 | - | 27760321 | MOLM13 | viability | CGTGATGGACTCCGGTGACGGG | ACTB | ENSG00000075624 | -1.8870806087355527 | [598,553] | [81,92] | -8 | hSpCas9 | negative selection | 5377403 | 5529160 | 5529182 | 7 | - | 27760321 | MOLM13 | viability | AACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -2.877604103705721 | [291,216] | [0,34] | -8 | hSpCas9 | negative selection | 5377404 | 5529387 | 5529409 | 7 | - | 27760321 | MOLM13 | viability | CTTCCCAGGGCGTGATGGTGGG | ACTB | ENSG00000075624 | -1.7682937415731466 | [606,509] | [143,47] | -7 | hSpCas9 | negative selection | 5377405 | 5529542 | 5529564 | 7 | + | 27760321 | MOLM13 | viability | CTGGGGCGCCCCACGATGGAGG | ACTB | ENSG00000075624 | -1.7175115596971136 | [554,496] | [0,165] | -7 | hSpCas9 | negative selection | 5377406 | 5529129 | 5529152 | 7 | + | 27661255 | K562 | viability | GCGGCCACCAGAAGAGGTAGCGG | ACTB | ENSG00000075624 | 0.023087894825346233 | [467,638] | [476,420] | 0 | dCas9-KRAB | negative selection | 5460704 | 5530533 | 5530556 | 7 | + | 27661255 | K562 | viability | GGTGTGGACGGGCGGCGGATCGG | ACTB | ENSG00000075624 | 0.21532701131449639 | [1303,1504] | [1445,1173] | 7 | dCas9-KRAB | negative selection | 5460705 | 5530539 | 5530562 | 7 | + | 27661255 | K562 | viability | GACGGGCGGCGGATCGGCAAAGG | ACTB | ENSG00000075624 | -0.2768300322269621 | [590,661] | [442,385] | -6 | dCas9-KRAB | negative selection | 5460706 | 5530220 | 5530243 | 7 | - | 27661255 | K562 | viability | GCCAATGGGGATCGCAGGGTGGG | ACTB | ENSG00000075624 | 0.4427912844093228 | [286,454] | [459,347] | 9 | dCas9-KRAB | negative selection | 5460707 | 5529160 | 5529183 | 7 | - | 27260156 | BXPC3 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.8107519406955852 | [99] | [45,64,54,74] | -9 | hSpCas9 | negative selection | 5526765 | 5529388 | 5529411 | 7 | - | 27260156 | BXPC3 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.6831556991162453 | [216] | [117,118,132,205] | -8 | hSpCas9 | negative selection | 5526766 | 5528671 | 5528694 | 7 | - | 27260156 | BXPC3 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.5296038506264495 | [3124] | [2117,2283,2122,2561] | -8 | hSpCas9 | negative selection | 5526767 | 5528653 | 5528676 | 7 | + | 27260156 | BXPC3 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.6498676887708865 | [175] | [57,31,40,110] | -9 | hSpCas9 | negative selection | 5591048 | 5528001 | 5528024 | 7 | + | 27260156 | BXPC3 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | -0.055690595787520114 | [969] | [937,972,908,1093] | -1 | hSpCas9 | negative selection | 5591049 | 5529160 | 5529183 | 7 | - | 27260156 | A673 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.18367807058399377 | [99] | [115,80,82,146] | -4 | hSpCas9 | negative selection | 5648016 | 5529388 | 5529411 | 7 | - | 27260156 | A673 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.7287500494218482 | [216] | [200,141,93,199] | -9 | hSpCas9 | negative selection | 5648017 | 5528671 | 5528694 | 7 | - | 27260156 | A673 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.3142476564204788 | [3124] | [3205,2826,3169,2879] | -6 | hSpCas9 | negative selection | 5648018 | 5528653 | 5528676 | 7 | + | 27260156 | A673 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.779375975072301 | [175] | [119,113,105,153] | -9 | hSpCas9 | negative selection | 5712299 | 5528001 | 5528024 | 7 | + | 27260156 | A673 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | -0.053987706441412264 | [969] | [1188,1116,1048,1139] | -1 | hSpCas9 | negative selection | 5712300 | 5529160 | 5529183 | 7 | - | 27260156 | A375 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -1.5051851810051131 | [99] | [45,16,55,41] | -9 | hSpCas9 | negative selection | 5769267 | 5529388 | 5529411 | 7 | - | 27260156 | A375 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.9726408851089035 | [216] | [136,168,116,101] | -8 | hSpCas9 | negative selection | 5769268 | 5528671 | 5528694 | 7 | - | 27260156 | A375 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.4356378895433526 | [3124] | [2636,3088,2062,3010] | -6 | hSpCas9 | negative selection | 5769269 | 5528653 | 5528676 | 7 | + | 27260156 | A375 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.6931391903325834 | [175] | [156,169,66,120] | -7 | hSpCas9 | negative selection | 5833550 | 5528001 | 5528024 | 7 | + | 27260156 | A375 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | -0.21706434575533395 | [969] | [856,967,1017,1041] | -3 | hSpCas9 | negative selection | 5833551 | 5529160 | 5529183 | 7 | - | 27260156 | COLO741 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.22302393923519093 | [99] | [82,105,134] | -5 | hSpCas9 | negative selection | 5890518 | 5529388 | 5529411 | 7 | - | 27260156 | COLO741 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.4476070178312772 | [216] | [277,222,120] | -7 | hSpCas9 | negative selection | 5890519 | 5528671 | 5528694 | 7 | - | 27260156 | COLO741 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.3351699119674305 | [3124] | [3801,3063,2709] | -6 | hSpCas9 | negative selection | 5890520 | 5528653 | 5528676 | 7 | + | 27260156 | COLO741 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.1610279665626173 | [175] | [113,79,107] | -9 | hSpCas9 | negative selection | 5954801 | 5528001 | 5528024 | 7 | + | 27260156 | COLO741 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | -0.027465251375157207 | [969] | [1245,1007,1380] | 0 | hSpCas9 | negative selection | 5954802 | 5529160 | 5529183 | 7 | - | 27260156 | CAL120 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.7728745398800769 | [99] | [314,114,222] | 9 | hSpCas9 | negative selection | 6011769 | 5529388 | 5529411 | 7 | - | 27260156 | CAL120 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.7528040054616547 | [216] | [200,79,204] | -8 | hSpCas9 | negative selection | 6011770 | 5528671 | 5528694 | 7 | - | 27260156 | CAL120 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.13125685235102713 | [3124] | [3670,3544,3453] | -2 | hSpCas9 | negative selection | 6011771 | 5528653 | 5528676 | 7 | + | 27260156 | CAL120 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | 0.7297886008332881 | [175] | [552,255,309] | 9 | hSpCas9 | negative selection | 6076052 | 5528001 | 5528024 | 7 | + | 27260156 | CAL120 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.08877871374151503 | [969] | [1902,1111,934] | 1 | hSpCas9 | negative selection | 6076053 | 5529160 | 5529183 | 7 | - | 27260156 | CADOES1 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.1660131050062219 | [99] | [83,139,76,116] | 3 | hSpCas9 | negative selection | 6133020 | 5529388 | 5529411 | 7 | - | 27260156 | CADOES1 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | 0.08422077549609397 | [216] | [189,185,311,165] | 1 | hSpCas9 | negative selection | 6133021 | 5528671 | 5528694 | 7 | - | 27260156 | CADOES1 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.05964667176037031 | [3124] | [2488,2900,2666,3110] | -1 | hSpCas9 | negative selection | 6133022 | 5528653 | 5528676 | 7 | + | 27260156 | CADOES1 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.23063688620796596 | [175] | [224,157,82,89] | -4 | hSpCas9 | negative selection | 6197303 | 5528001 | 5528024 | 7 | + | 27260156 | CADOES1 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.35547465550374224 | [969] | [1054,1032,1166,1369] | 6 | hSpCas9 | negative selection | 6197304 | 5529160 | 5529183 | 7 | - | 27260156 | EWS502 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.13561667730822213 | [99] | [147,38,55,140] | -2 | hSpCas9 | negative selection | 6254271 | 5529388 | 5529411 | 7 | - | 27260156 | EWS502 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.2246158688522888 | [216] | [127,150,257,264] | -4 | hSpCas9 | negative selection | 6254272 | 5528671 | 5528694 | 7 | - | 27260156 | EWS502 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.02809501393590441 | [3124] | [3096,3119,3407,3381] | 0 | hSpCas9 | negative selection | 6254273 | 5528653 | 5528676 | 7 | + | 27260156 | EWS502 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.4333187663052709 | [175] | [115,195,108,129] | -6 | hSpCas9 | negative selection | 6318554 | 5528001 | 5528024 | 7 | + | 27260156 | EWS502 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | -0.15494704144346105 | [969] | [782,976,998,945] | -3 | hSpCas9 | negative selection | 6318555 | 5529160 | 5529183 | 7 | - | 27260156 | EW8 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.36199696319754215 | [99] | [92,92,30,43] | -6 | hSpCas9 | negative selection | 6375522 | 5529388 | 5529411 | 7 | - | 27260156 | EW8 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.6721592802202685 | [216] | [151,123,103,66] | -8 | hSpCas9 | negative selection | 6375523 | 5528671 | 5528694 | 7 | - | 27260156 | EW8 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.14246184438708465 | [3124] | [2308,2508,1953,2458] | -3 | hSpCas9 | negative selection | 6375524 | 5528653 | 5528676 | 7 | + | 27260156 | EW8 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.3139987108328128 | [175] | [29,64,28,106] | -9 | hSpCas9 | negative selection | 6439805 | 5528001 | 5528024 | 7 | + | 27260156 | EW8 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.12341978455640579 | [969] | [1184,824,715,756] | 2 | hSpCas9 | negative selection | 6439806 | 5529160 | 5529183 | 7 | - | 27260156 | CORL105 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.4594438921665467 | [99] | [66,64,77,128] | -7 | hSpCas9 | negative selection | 6496773 | 5529388 | 5529411 | 7 | - | 27260156 | CORL105 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.7581380529057717 | [216] | [164,106,193,142] | -8 | hSpCas9 | negative selection | 6496774 | 5528671 | 5528694 | 7 | - | 27260156 | CORL105 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.3117755181675972 | [3124] | [2977,2744,3098,2994] | -5 | hSpCas9 | negative selection | 6496775 | 5528653 | 5528676 | 7 | + | 27260156 | CORL105 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.170615404342294 | [175] | [59,113,106,85] | -9 | hSpCas9 | negative selection | 6561056 | 5528001 | 5528024 | 7 | + | 27260156 | CORL105 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | -0.012379844655040273 | [969] | [1097,984,1274,1169] | 0 | hSpCas9 | negative selection | 6561057 | 5529160 | 5529183 | 7 | - | 27260156 | HS294T | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.06208089337250744 | [99] | [25,20,27,97] | 0 | hSpCas9 | negative selection | 6618024 | 5529388 | 5529411 | 7 | - | 27260156 | HS294T | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -1.1286698602914627 | [216] | [27,56,33,33] | -9 | hSpCas9 | negative selection | 6618025 | 5528671 | 5528694 | 7 | - | 27260156 | HS294T | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.433805176357446 | [3124] | [669,917,973,1061] | -6 | hSpCas9 | negative selection | 6618026 | 5528653 | 5528676 | 7 | + | 27260156 | HS294T | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.451484628450006 | [175] | [14,17,35,32] | -9 | hSpCas9 | negative selection | 6682307 | 5528001 | 5528024 | 7 | + | 27260156 | HS294T | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.04747703578526541 | [969] | [414,275,487,367] | 0 | hSpCas9 | negative selection | 6682308 | 5529160 | 5529183 | 7 | - | 27260156 | HCC44 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -1.1329041299683853 | [99] | [34,69,71,28] | -8 | hSpCas9 | negative selection | 6739275 | 5529388 | 5529411 | 7 | - | 27260156 | HCC44 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -1.2142374291942934 | [216] | [96,92,107,124] | -9 | hSpCas9 | negative selection | 6739276 | 5528671 | 5528694 | 7 | - | 27260156 | HCC44 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.22078875202666293 | [3124] | [2768,2477,3625,3378] | -4 | hSpCas9 | negative selection | 6739277 | 5528653 | 5528676 | 7 | + | 27260156 | HCC44 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.8578709094705887 | [175] | [76,55,45,40] | -9 | hSpCas9 | negative selection | 6803558 | 5528001 | 5528024 | 7 | + | 27260156 | HCC44 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.12195587876966396 | [969] | [1428,1124,1351,926] | 2 | hSpCas9 | negative selection | 6803559 | 5529160 | 5529183 | 7 | - | 27260156 | G402 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.4632129705658592 | [99] | [40,108,108,88] | -5 | hSpCas9 | negative selection | 6860526 | 5529388 | 5529411 | 7 | - | 27260156 | G402 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.26562022470397295 | [216] | [99,228,158,367] | -3 | hSpCas9 | negative selection | 6860527 | 5528671 | 5528694 | 7 | - | 27260156 | G402 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.1639339200990615 | [3124] | [3432,4129,3285,2826] | -2 | hSpCas9 | negative selection | 6860528 | 5528653 | 5528676 | 7 | + | 27260156 | G402 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.9330760369965114 | [175] | [222,157,78,12] | -8 | hSpCas9 | negative selection | 6924809 | 5528001 | 5528024 | 7 | + | 27260156 | G402 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.17400043625672867 | [969] | [1472,944,1616,1299] | 2 | hSpCas9 | negative selection | 6924810 | 5529160 | 5529183 | 7 | - | 27260156 | L33 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.9022300580908116 | [99] | [63,18,16,75] | -9 | hSpCas9 | negative selection | 6981777 | 5529388 | 5529411 | 7 | - | 27260156 | L33 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.48239466208812787 | [216] | [154,83,102,97] | -8 | hSpCas9 | negative selection | 6981778 | 5528671 | 5528694 | 7 | - | 27260156 | L33 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.14471648954233585 | [3124] | [2507,1150,1776,3166] | -3 | hSpCas9 | negative selection | 6981779 | 5528653 | 5528676 | 7 | + | 27260156 | L33 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.3734031516406624 | [175] | [56,36,55,35] | -9 | hSpCas9 | negative selection | 7046060 | 5528001 | 5528024 | 7 | + | 27260156 | L33 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | -0.2508538850629115 | [969] | [941,352,395,822] | -5 | hSpCas9 | negative selection | 7046061 | 5529160 | 5529183 | 7 | - | 27260156 | K562 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.35824830691467335 | [99] | [48,121,39,66] | -4 | hSpCas9 | negative selection | 7103028 | 5529388 | 5529411 | 7 | - | 27260156 | K562 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -1.6420010243998024 | [216] | [57,29,79,74] | -9 | hSpCas9 | negative selection | 7103029 | 5528671 | 5528694 | 7 | - | 27260156 | K562 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.10467351760887844 | [3124] | [2362,3306,2538,2165] | -1 | hSpCas9 | negative selection | 7103030 | 5528653 | 5528676 | 7 | + | 27260156 | K562 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.036904331204421 | [175] | [24,24,158,86] | -8 | hSpCas9 | negative selection | 7167311 | 5528001 | 5528024 | 7 | + | 27260156 | K562 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.05322993337852311 | [969] | [915,1378,575,742] | 0 | hSpCas9 | negative selection | 7167312 | 5529160 | 5529183 | 7 | - | 27260156 | HT29 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.8960162938910541 | [99] | [113,21,51,71] | -8 | hSpCas9 | negative selection | 7224279 | 5529388 | 5529411 | 7 | - | 27260156 | HT29 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.7956653006734498 | [216] | [146,202,155,109] | -8 | hSpCas9 | negative selection | 7224280 | 5528671 | 5528694 | 7 | - | 27260156 | HT29 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.2386209008987099 | [3124] | [3280,3671,2952,3017] | -5 | hSpCas9 | negative selection | 7224281 | 5528653 | 5528676 | 7 | + | 27260156 | HT29 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.2028263420160186 | [175] | [96,102,49,118] | -9 | hSpCas9 | negative selection | 7288562 | 5528001 | 5528024 | 7 | + | 27260156 | HT29 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.0705516764630596 | [969] | [1435,931,1354,1212] | 1 | hSpCas9 | negative selection | 7288563 | 5529160 | 5529183 | 7 | - | 27260156 | MHHES1 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.2364122964225004 | [99] | [17,95,134,116] | -4 | hSpCas9 | negative selection | 7345530 | 5529388 | 5529411 | 7 | - | 27260156 | MHHES1 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.500494362846041 | [216] | [161,159,257,117] | -7 | hSpCas9 | negative selection | 7345531 | 5528671 | 5528694 | 7 | - | 27260156 | MHHES1 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.22976447656344723 | [3124] | [3059,3438,3178,2442] | -4 | hSpCas9 | negative selection | 7345532 | 5528653 | 5528676 | 7 | + | 27260156 | MHHES1 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.8772970547112244 | [175] | [129,110,138,62] | -9 | hSpCas9 | negative selection | 7409813 | 5528001 | 5528024 | 7 | + | 27260156 | MHHES1 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | -0.09900076041498584 | [969] | [910,1241,1049,892] | -2 | hSpCas9 | negative selection | 7409814 | 5529160 | 5529183 | 7 | - | 27260156 | MEWO | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.0688464532581019 | [99] | [85,78,101] | -1 | hSpCas9 | negative selection | 7466781 | 5529388 | 5529411 | 7 | - | 27260156 | MEWO | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | 0.05325088862607252 | [216] | [245,159,232] | 1 | hSpCas9 | negative selection | 7466782 | 5528671 | 5528694 | 7 | - | 27260156 | MEWO | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.07519854172540263 | [3124] | [3388,2311,2744] | -2 | hSpCas9 | negative selection | 7466783 | 5528653 | 5528676 | 7 | + | 27260156 | MEWO | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.6387796404563892 | [175] | [73,122,113] | -8 | hSpCas9 | negative selection | 7531064 | 5528001 | 5528024 | 7 | + | 27260156 | MEWO | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | -0.03806721127997936 | [969] | [1019,835,821] | -1 | hSpCas9 | negative selection | 7531065 | 5529160 | 5529183 | 7 | - | 27260156 | LNCAPCLONEFGC | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.07039226618100214 | [99] | [87,150,75,58] | 1 | hSpCas9 | negative selection | 7588032 | 5529388 | 5529411 | 7 | - | 27260156 | LNCAPCLONEFGC | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | 0.24644257290364102 | [216] | [216,188,294,243] | 4 | hSpCas9 | negative selection | 7588033 | 5528671 | 5528694 | 7 | - | 27260156 | LNCAPCLONEFGC | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.06128899701642654 | [3124] | [2455,2336,3418,2772] | -1 | hSpCas9 | negative selection | 7588034 | 5528653 | 5528676 | 7 | + | 27260156 | LNCAPCLONEFGC | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.44249481647261946 | [175] | [111,81,139,140] | -6 | hSpCas9 | negative selection | 7652315 | 5528001 | 5528024 | 7 | + | 27260156 | LNCAPCLONEFGC | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.3156697225126974 | [969] | [1126,976,1189,1100] | 5 | hSpCas9 | negative selection | 7652316 | 5529160 | 5529183 | 7 | - | 27260156 | PANC0327 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -2.1434285749072783 | [99] | [7,7,31,32] | -9 | hSpCas9 | negative selection | 7709283 | 5529388 | 5529411 | 7 | - | 27260156 | PANC0327 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.3554112364018853 | [216] | [232,122,151,104] | -5 | hSpCas9 | negative selection | 7709284 | 5528671 | 5528694 | 7 | - | 27260156 | PANC0327 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.3877652485682974 | [3124] | [2206,1815,2352,2156] | -5 | hSpCas9 | negative selection | 7709285 | 5528653 | 5528676 | 7 | + | 27260156 | PANC0327 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.00712957812227 | [175] | [143,42,54,78] | -8 | hSpCas9 | negative selection | 7773566 | 5528001 | 5528024 | 7 | + | 27260156 | PANC0327 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.1385172579954741 | [969] | [1418,479,1086,906] | 2 | hSpCas9 | negative selection | 7773567 | 5529160 | 5529183 | 7 | - | 27260156 | NCIH2009 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.05127989038656411 | [99] | [181,112,118] | 0 | hSpCas9 | negative selection | 7830534 | 5529388 | 5529411 | 7 | - | 27260156 | NCIH2009 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -1.0047086324997354 | [216] | [197,167,95] | -8 | hSpCas9 | negative selection | 7830535 | 5528671 | 5528694 | 7 | - | 27260156 | NCIH2009 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.31000452290415703 | [3124] | [4259,3276,3172] | -4 | hSpCas9 | negative selection | 7830536 | 5528653 | 5528676 | 7 | + | 27260156 | NCIH2009 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.7028459743813342 | [175] | [188,175,94] | -7 | hSpCas9 | negative selection | 7894817 | 5528001 | 5528024 | 7 | + | 27260156 | NCIH2009 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.01624196287056634 | [969] | [1313,1328,1455] | 0 | hSpCas9 | negative selection | 7894818 | 5529160 | 5529183 | 7 | - | 27260156 | NCIH1373 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.3686230182057457 | [99] | [40,90,167,8] | -4 | hSpCas9 | negative selection | 7951785 | 5529388 | 5529411 | 7 | - | 27260156 | NCIH1373 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -1.7471395194435073 | [216] | [152,38,83,6] | -9 | hSpCas9 | negative selection | 7951786 | 5528671 | 5528694 | 7 | - | 27260156 | NCIH1373 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.08056714256747188 | [3124] | [4251,3364,2357,899] | -1 | hSpCas9 | negative selection | 7951787 | 5528653 | 5528676 | 7 | + | 27260156 | NCIH1373 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.38160616413713555 | [175] | [136,66,305,24] | -4 | hSpCas9 | negative selection | 8016068 | 5528001 | 5528024 | 7 | + | 27260156 | NCIH1373 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.29110721731041367 | [969] | [1747,1103,1288,330] | 3 | hSpCas9 | negative selection | 8016069 | 5529160 | 5529183 | 7 | - | 27260156 | PATU8902 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -1.7244815115317889 | [99] | [79,52,25,8] | -8 | hSpCas9 | negative selection | 8073036 | 5529388 | 5529411 | 7 | - | 27260156 | PATU8902 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -1.099338752944602 | [216] | [164,283,25,114] | -7 | hSpCas9 | negative selection | 8073037 | 5528671 | 5528694 | 7 | - | 27260156 | PATU8902 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.5028012580980707 | [3124] | [2300,3214,2505,4576] | -5 | hSpCas9 | negative selection | 8073038 | 5528653 | 5528676 | 7 | + | 27260156 | PATU8902 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.903899561017734 | [175] | [124,55,22,67] | -9 | hSpCas9 | negative selection | 8137319 | 5528001 | 5528024 | 7 | + | 27260156 | PATU8902 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.5691369838502447 | [969] | [1833,1904,1775,2620] | 6 | hSpCas9 | negative selection | 8137320 | 5529160 | 5529183 | 7 | - | 27260156 | PANC1 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.8183981661749704 | [99] | [78,66,36,18] | -8 | hSpCas9 | negative selection | 8194287 | 5529388 | 5529411 | 7 | - | 27260156 | PANC1 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -1.081502020266804 | [216] | [65,110,103,76] | -8 | hSpCas9 | negative selection | 8194288 | 5528671 | 5528694 | 7 | - | 27260156 | PANC1 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.40549995740861045 | [3124] | [2035,2579,2298,1380] | -6 | hSpCas9 | negative selection | 8194289 | 5528653 | 5528676 | 7 | + | 27260156 | PANC1 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.36418322653033686 | [175] | [38,141,162,128] | -5 | hSpCas9 | negative selection | 8258570 | 5528001 | 5528024 | 7 | + | 27260156 | PANC1 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.09221839954537492 | [969] | [753,1177,896,787] | 1 | hSpCas9 | negative selection | 8258571 | 5529160 | 5529183 | 7 | - | 27260156 | PANC0813 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -1.1219325385202623 | [99] | [93,74,26,24] | -8 | hSpCas9 | negative selection | 8315538 | 5529388 | 5529411 | 7 | - | 27260156 | PANC0813 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -1.0194028674619549 | [216] | [124,119,84,169] | -8 | hSpCas9 | negative selection | 8315539 | 5528671 | 5528694 | 7 | - | 27260156 | PANC0813 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.4683207348549381 | [3124] | [2582,2723,2899,2409] | -6 | hSpCas9 | negative selection | 8315540 | 5528653 | 5528676 | 7 | + | 27260156 | PANC0813 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -2.1565521808316492 | [175] | [55,27,49,51] | -9 | hSpCas9 | negative selection | 8379821 | 5528001 | 5528024 | 7 | + | 27260156 | PANC0813 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | -0.010336615671035165 | [969] | [1322,988,1168,1063] | 0 | hSpCas9 | negative selection | 8379822 | 5529160 | 5529183 | 7 | - | 27260156 | RDES | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.0549702753938921 | [99] | [116,108,145,58] | -1 | hSpCas9 | negative selection | 8436789 | 5529388 | 5529411 | 7 | - | 27260156 | RDES | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.4350956233202412 | [216] | [167,162,161,254] | -6 | hSpCas9 | negative selection | 8436790 | 5528671 | 5528694 | 7 | - | 27260156 | RDES | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | 0.02986192222080808 | [3124] | [3168,3774,3773,3990] | 0 | hSpCas9 | negative selection | 8436791 | 5528653 | 5528676 | 7 | + | 27260156 | RDES | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.16546453137171246 | [175] | [186,155,83,304] | -3 | hSpCas9 | negative selection | 8501072 | 5528001 | 5528024 | 7 | + | 27260156 | RDES | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.20951798413680534 | [969] | [1098,1257,1378,1455] | 3 | hSpCas9 | negative selection | 8501073 | 5529160 | 5529183 | 7 | - | 27260156 | PC3 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.19245154799827358 | [99] | [34,131,193,154] | 4 | hSpCas9 | negative selection | 8558040 | 5529388 | 5529411 | 7 | - | 27260156 | PC3 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.12486390370508604 | [216] | [127,199,410,145] | -3 | hSpCas9 | negative selection | 8558041 | 5528671 | 5528694 | 7 | - | 27260156 | PC3 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | 0.03928607878988277 | [3124] | [2041,2711,5273,3832] | 0 | hSpCas9 | negative selection | 8558042 | 5528653 | 5528676 | 7 | + | 27260156 | PC3 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.7463758089008743 | [175] | [49,93,215,118] | -9 | hSpCas9 | negative selection | 8622323 | 5528001 | 5528024 | 7 | + | 27260156 | PC3 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.014742249942195862 | [969] | [574,1053,1668,958] | 0 | hSpCas9 | negative selection | 8622324 | 5529160 | 5529183 | 7 | - | 27260156 | PATU8988T | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -2.39394068142251 | [99] | [6,33,15,17] | -9 | hSpCas9 | negative selection | 8679291 | 5529388 | 5529411 | 7 | - | 27260156 | PATU8988T | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.6904110569965352 | [216] | [77,218,105,124] | -8 | hSpCas9 | negative selection | 8679292 | 5528671 | 5528694 | 7 | - | 27260156 | PATU8988T | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.7906205009053398 | [3124] | [1713,2195,1575,1522] | -8 | hSpCas9 | negative selection | 8679293 | 5528653 | 5528676 | 7 | + | 27260156 | PATU8988T | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -2.7758983064261016 | [175] | [28,21,23,23] | -9 | hSpCas9 | negative selection | 8743574 | 5528001 | 5528024 | 7 | + | 27260156 | PATU8988T | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | -0.0915249954635915 | [969] | [835,677,1157,818] | -1 | hSpCas9 | negative selection | 8743575 | 5529160 | 5529183 | 7 | - | 27260156 | T47D | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.10096222034337377 | [99] | [115,127,116,138] | 2 | hSpCas9 | negative selection | 8800542 | 5529388 | 5529411 | 7 | - | 27260156 | T47D | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.14423133287920598 | [216] | [191,243,250,225] | -3 | hSpCas9 | negative selection | 8800543 | 5528671 | 5528694 | 7 | - | 27260156 | T47D | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.1625223517718788 | [3124] | [3508,3039,2999,3491] | -4 | hSpCas9 | negative selection | 8800544 | 5528653 | 5528676 | 7 | + | 27260156 | T47D | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.05753149585370121 | [175] | [150,213,201,219] | -1 | hSpCas9 | negative selection | 8864825 | 5528001 | 5528024 | 7 | + | 27260156 | T47D | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.13874928984780355 | [969] | [1329,1211,1233,1201] | 3 | hSpCas9 | negative selection | 8864826 | 5529160 | 5529183 | 7 | - | 27260156 | SU8686 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.6639962544147533 | [99] | [64,24,118,43] | -7 | hSpCas9 | negative selection | 8921793 | 5529388 | 5529411 | 7 | - | 27260156 | SU8686 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.9697413475332552 | [216] | [86,129,127,90] | -8 | hSpCas9 | negative selection | 8921794 | 5528671 | 5528694 | 7 | - | 27260156 | SU8686 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.5338678114317208 | [3124] | [1899,1705,2511,2593] | -7 | hSpCas9 | negative selection | 8921795 | 5528653 | 5528676 | 7 | + | 27260156 | SU8686 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -2.2830009239333595 | [175] | [18,27,25,79] | -9 | hSpCas9 | negative selection | 8986076 | 5528001 | 5528024 | 7 | + | 27260156 | SU8686 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.03717571683993581 | [969] | [752,911,1134,1217] | 0 | hSpCas9 | negative selection | 8986077 | 5529160 | 5529183 | 7 | - | 27260156 | SKES1 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.1362315628553601 | [99] | [100,114,102,116] | 3 | hSpCas9 | negative selection | 9043044 | 5529388 | 5529411 | 7 | - | 27260156 | SKES1 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.2599451469527816 | [216] | [215,176,141,189] | -5 | hSpCas9 | negative selection | 9043045 | 5528671 | 5528694 | 7 | - | 27260156 | SKES1 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.06686854180279767 | [3124] | [3673,3033,2867,2463] | -1 | hSpCas9 | negative selection | 9043046 | 5528653 | 5528676 | 7 | + | 27260156 | SKES1 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.8204010850329211 | [175] | [145,79,22,146] | -9 | hSpCas9 | negative selection | 9107327 | 5528001 | 5528024 | 7 | + | 27260156 | SKES1 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.09496829323627076 | [969] | [915,1264,1047,918] | 2 | hSpCas9 | negative selection | 9107328 | 5529160 | 5529183 | 7 | - | 27260156 | TOV112D | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.08821682035203793 | [99] | [47,118,120,90] | -2 | hSpCas9 | negative selection | 9164295 | 5529388 | 5529411 | 7 | - | 27260156 | TOV112D | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | 0.162818688785745 | [216] | [236,253,243,239] | 3 | hSpCas9 | negative selection | 9164296 | 5528671 | 5528694 | 7 | - | 27260156 | TOV112D | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.2938782133494029 | [3124] | [2282,3443,2398,2285] | -5 | hSpCas9 | negative selection | 9164297 | 5528653 | 5528676 | 7 | + | 27260156 | TOV112D | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.8078100012350764 | [175] | [100,169,58,89] | -9 | hSpCas9 | negative selection | 9228578 | 5528001 | 5528024 | 7 | + | 27260156 | TOV112D | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | -0.06993092257929356 | [969] | [679,1006,1051,959] | -1 | hSpCas9 | negative selection | 9228579 | 5529160 | 5529183 | 7 | - | 27260156 | TC71 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.012033386697362758 | [99] | [49,80,170,130] | 0 | hSpCas9 | negative selection | 9285546 | 5529388 | 5529411 | 7 | - | 27260156 | TC71 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.1279540136960009 | [216] | [212,205,181,253] | -3 | hSpCas9 | negative selection | 9285547 | 5528671 | 5528694 | 7 | - | 27260156 | TC71 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.0760089741196226 | [3124] | [3229,3061,3189,3230] | -2 | hSpCas9 | negative selection | 9285548 | 5528653 | 5528676 | 7 | + | 27260156 | TC71 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.4724228073689112 | [175] | [123,47,202,168] | -8 | hSpCas9 | negative selection | 9349829 | 5528001 | 5528024 | 7 | + | 27260156 | TC71 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.003483912302992387 | [969] | [1131,1111,907,1017] | 0 | hSpCas9 | negative selection | 9349830 | 5529160 | 5529183 | 7 | - | 27260156 | TC32 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | 0.11925912806539296 | [99] | [30,129,139,105] | 2 | hSpCas9 | negative selection | 9406797 | 5529388 | 5529411 | 7 | - | 27260156 | TC32 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | 0.13944773230322938 | [216] | [89,318,267,192] | 2 | hSpCas9 | negative selection | 9406798 | 5528671 | 5528694 | 7 | - | 27260156 | TC32 | viability | AGCCATGTACGTTGCTATCCAGG | ACTB | ENSG00000075624 | -0.10930092716641227 | [3124] | [2484,1894,3544,3326] | -2 | hSpCas9 | negative selection | 9406799 | 5528653 | 5528676 | 7 | + | 27260156 | TC32 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.3493307551110887 | [175] | [104,124,108,175] | -6 | hSpCas9 | negative selection | 9471080 | 5528001 | 5528024 | 7 | + | 27260156 | TC32 | viability | CACCTTGATCTTCATTGTGCTGG | ACTB | ENSG00000075624 | 0.25576324453999133 | [969] | [1034,884,1045,1414] | 4 | hSpCas9 | negative selection | 9471081 | 5529620 | 5529643 | 7 | - | 27869803 | HPAFII | viability after 27 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -1.5239890464886234 | [365] | [37,90,NaN] | -7 | hSpCas9 | negative selection | 9599874 | 5529620 | 5529643 | 7 | - | 27869803 | HPAFII | viability after 15 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -1.032840963301414 | [365] | [182,197,NaN] | -8 | hSpCas9 | negative selection | 9682323 | 5529620 | 5529643 | 7 | - | 27869803 | ASPC1 | viability after 36 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -1.0228474570085382 | [1046] | [324,72,160] | -7 | hSpCas9 | negative selection | 9764772 | 5529620 | 5529643 | 7 | - | 27869803 | PATU8988S | viability after 35 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -4.464334064471705 | [847] | [2,27,NaN] | -9 | hSpCas9 | negative selection | 9847221 | 5529620 | 5529643 | 7 | - | 27869803 | PATU8988S | viability after 31 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -5.000902941850388 | [847] | [10,9,NaN] | -9 | hSpCas9 | negative selection | 9929670 | 5529620 | 5529643 | 7 | - | 27869803 | HPAFII | viability after 35 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -3.9344628783229 | [365] | [13,9,NaN] | -9 | hSpCas9 | negative selection | 10012119 | 5529620 | 5529643 | 7 | - | 27869803 | HPAFII | viability after 31 days | GCCGCGCTCGTCGTCGACAACGG | ACTB | ENSG00000075624 | -2.4692591454659563 | [365] | [27,46,NaN] | -8 | hSpCas9 | negative selection | 10094568 | 5528378 | 5528401 | 7 | + | 28162770 | P31FUJ | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | -1.4751630419834223 | [96] | [40] | -7 | hSpCas9 | negative selection | 10106328 | 5528653 | 5528676 | 7 | + | 28162770 | P31FUJ | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.9997050827346887 | [210] | [61] | -8 | hSpCas9 | negative selection | 10106329 | 5529619 | 5529642 | 7 | + | 28162770 | P31FUJ | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -3.244774846080454 | [120] | [14] | -9 | hSpCas9 | negative selection | 10106330 | 5529160 | 5529183 | 7 | - | 28162770 | P31FUJ | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -5.028217513160458 | [360] | [12] | -9 | hSpCas9 | negative selection | 10106331 | 5528675 | 5528698 | 7 | + | 28162770 | P31FUJ | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -4.310804716415651 | [151] | [8] | -9 | hSpCas9 | negative selection | 10106332 | 5528401 | 5528424 | 7 | - | 28162770 | P31FUJ | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | -2.933241922555471 | [129] | [19] | -9 | hSpCas9 | negative selection | 10106333 | 5528267 | 5528290 | 7 | + | 28162770 | P31FUJ | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -3.443949868583204 | [212] | [22] | -9 | hSpCas9 | negative selection | 10106334 | 5529525 | 5529548 | 7 | + | 28162770 | P31FUJ | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | -4.032777596106385 | [194] | [13] | -9 | hSpCas9 | negative selection | 10106335 | 5529388 | 5529411 | 7 | - | 28162770 | P31FUJ | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -1.316866469202853 | [370] | [174] | -7 | hSpCas9 | negative selection | 10106336 | 5529266 | 5529289 | 7 | - | 28162770 | P31FUJ | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | -2.1072713223305195 | [274] | [74] | -8 | hSpCas9 | negative selection | 10106337 | 5528378 | 5528401 | 7 | + | 28162770 | TF1 | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | NaN | [NaN] | [32] | 1 | hSpCas9 | negative selection | 10275694 | 5528653 | 5528676 | 7 | + | 28162770 | TF1 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | NaN | [NaN] | [85] | 1 | hSpCas9 | negative selection | 10275695 | 5529619 | 5529642 | 7 | + | 28162770 | TF1 | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | NaN | [NaN] | [19] | 1 | hSpCas9 | negative selection | 10275696 | 5529160 | 5529183 | 7 | - | 28162770 | TF1 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | NaN | [NaN] | [58] | 1 | hSpCas9 | negative selection | 10275697 | 5528675 | 5528698 | 7 | + | 28162770 | TF1 | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | NaN | [NaN] | [21] | 1 | hSpCas9 | negative selection | 10275698 | 5528401 | 5528424 | 7 | - | 28162770 | TF1 | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | NaN | [NaN] | [32] | 1 | hSpCas9 | negative selection | 10275699 | 5528267 | 5528290 | 7 | + | 28162770 | TF1 | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | NaN | [NaN] | [161] | 1 | hSpCas9 | negative selection | 10275700 | 5529525 | 5529548 | 7 | + | 28162770 | TF1 | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | NaN | [NaN] | [28] | 1 | hSpCas9 | negative selection | 10275701 | 5529388 | 5529411 | 7 | - | 28162770 | TF1 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | NaN | [NaN] | [193] | 1 | hSpCas9 | negative selection | 10275702 | 5529266 | 5529289 | 7 | - | 28162770 | TF1 | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | NaN | [NaN] | [87] | 1 | hSpCas9 | negative selection | 10275703 | 5528378 | 5528401 | 7 | + | 28162770 | SKM1 | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | -1.069929211465591 | [18] | [15] | -7 | hSpCas9 | negative selection | 10445060 | 5528653 | 5528676 | 7 | + | 28162770 | SKM1 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.30935340211673923 | [74] | [106] | -3 | hSpCas9 | negative selection | 10445061 | 5529619 | 5529642 | 7 | + | 28162770 | SKM1 | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -0.6936776010464663 | [42] | [46] | -5 | hSpCas9 | negative selection | 10445062 | 5529160 | 5529183 | 7 | - | 28162770 | SKM1 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.3902854575965311 | [128] | [173] | -3 | hSpCas9 | negative selection | 10445063 | 5528675 | 5528698 | 7 | + | 28162770 | SKM1 | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -0.7916280489784866 | [46] | [47] | -5 | hSpCas9 | negative selection | 10445064 | 5528401 | 5528424 | 7 | - | 28162770 | SKM1 | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | -1.1301239933843372 | [25] | [20] | -7 | hSpCas9 | negative selection | 10445065 | 5528267 | 5528290 | 7 | + | 28162770 | SKM1 | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -0.2521460896910577 | [63] | [94] | -2 | hSpCas9 | negative selection | 10445066 | 5529525 | 5529548 | 7 | + | 28162770 | SKM1 | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | -1.6844981742720708 | [39] | [21] | -8 | hSpCas9 | negative selection | 10445067 | 5529388 | 5529411 | 7 | - | 28162770 | SKM1 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.2753673159599487 | [88] | [129] | -2 | hSpCas9 | negative selection | 10445068 | 5529266 | 5529289 | 7 | - | 28162770 | SKM1 | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | -1.0735404650179698 | [49] | [41] | -7 | hSpCas9 | negative selection | 10445069 | 5528378 | 5528401 | 7 | + | 28162770 | SKM1 | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | -1.069929211465591 | [18] | [15] | -7 | hSpCas9 | negative selection | 10614426 | 5528653 | 5528676 | 7 | + | 28162770 | SKM1 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.30935340211673923 | [74] | [106] | -3 | hSpCas9 | negative selection | 10614427 | 5529619 | 5529642 | 7 | + | 28162770 | SKM1 | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -0.6936776010464663 | [42] | [46] | -5 | hSpCas9 | negative selection | 10614428 | 5529160 | 5529183 | 7 | - | 28162770 | SKM1 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.3902854575965311 | [128] | [173] | -3 | hSpCas9 | negative selection | 10614429 | 5528675 | 5528698 | 7 | + | 28162770 | SKM1 | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -0.7916280489784866 | [46] | [47] | -5 | hSpCas9 | negative selection | 10614430 | 5528401 | 5528424 | 7 | - | 28162770 | SKM1 | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | -1.1301239933843372 | [25] | [20] | -7 | hSpCas9 | negative selection | 10614431 | 5528267 | 5528290 | 7 | + | 28162770 | SKM1 | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -0.2521460896910577 | [63] | [94] | -2 | hSpCas9 | negative selection | 10614432 | 5529525 | 5529548 | 7 | + | 28162770 | SKM1 | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | -1.6844981742720708 | [39] | [21] | -8 | hSpCas9 | negative selection | 10614433 | 5529388 | 5529411 | 7 | - | 28162770 | SKM1 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.2753673159599487 | [88] | [129] | -2 | hSpCas9 | negative selection | 10614434 | 5529266 | 5529289 | 7 | - | 28162770 | SKM1 | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | -1.0735404650179698 | [49] | [41] | -7 | hSpCas9 | negative selection | 10614435 | 5528378 | 5528401 | 7 | + | 28162770 | PL21 | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | -2.4779322906233174 | [63] | [4] | -9 | hSpCas9 | negative selection | 10783792 | 5528653 | 5528676 | 7 | + | 28162770 | PL21 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.836518856089528 | [278] | [33] | -8 | hSpCas9 | negative selection | 10783793 | 5529619 | 5529642 | 7 | + | 28162770 | PL21 | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -6.00931375113963 | [147] | [0] | -9 | hSpCas9 | negative selection | 10783794 | 5529160 | 5529183 | 7 | - | 28162770 | PL21 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -3.0042188840168658 | [423] | [22] | -9 | hSpCas9 | negative selection | 10783795 | 5528675 | 5528698 | 7 | + | 28162770 | PL21 | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -4.164432817806536 | [205] | [4] | -9 | hSpCas9 | negative selection | 10783796 | 5528401 | 5528424 | 7 | - | 28162770 | PL21 | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | -2.500300103651772 | [90] | [6] | -9 | hSpCas9 | negative selection | 10783797 | 5528267 | 5528290 | 7 | + | 28162770 | PL21 | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -2.299093012205952 | [293] | [25] | -8 | hSpCas9 | negative selection | 10783798 | 5529525 | 5529548 | 7 | + | 28162770 | PL21 | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | 0.1854928385249187 | [98] | [48] | 1 | hSpCas9 | negative selection | 10783799 | 5529388 | 5529411 | 7 | - | 28162770 | PL21 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.21881293479290684 | [245] | [91] | -1 | hSpCas9 | negative selection | 10783800 | 5529266 | 5529289 | 7 | - | 28162770 | PL21 | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | 0.5071173679107109 | [193] | [119] | 4 | hSpCas9 | negative selection | 10783801 | 5528378 | 5528401 | 7 | + | 28162770 | P31FUJ | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | -1.4751630419834223 | [96] | [40] | -7 | hSpCas9 | negative selection | 10953158 | 5528653 | 5528676 | 7 | + | 28162770 | P31FUJ | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.9997050827346887 | [210] | [61] | -8 | hSpCas9 | negative selection | 10953159 | 5529619 | 5529642 | 7 | + | 28162770 | P31FUJ | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -3.244774846080454 | [120] | [14] | -9 | hSpCas9 | negative selection | 10953160 | 5529160 | 5529183 | 7 | - | 28162770 | P31FUJ | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -5.028217513160458 | [360] | [12] | -9 | hSpCas9 | negative selection | 10953161 | 5528675 | 5528698 | 7 | + | 28162770 | P31FUJ | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -4.310804716415651 | [151] | [8] | -9 | hSpCas9 | negative selection | 10953162 | 5528401 | 5528424 | 7 | - | 28162770 | P31FUJ | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | -2.933241922555471 | [129] | [19] | -9 | hSpCas9 | negative selection | 10953163 | 5528267 | 5528290 | 7 | + | 28162770 | P31FUJ | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -3.443949868583204 | [212] | [22] | -9 | hSpCas9 | negative selection | 10953164 | 5529525 | 5529548 | 7 | + | 28162770 | P31FUJ | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | -4.032777596106385 | [194] | [13] | -9 | hSpCas9 | negative selection | 10953165 | 5529388 | 5529411 | 7 | - | 28162770 | P31FUJ | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -1.316866469202853 | [370] | [174] | -7 | hSpCas9 | negative selection | 10953166 | 5529266 | 5529289 | 7 | - | 28162770 | P31FUJ | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | -2.1072713223305195 | [274] | [74] | -8 | hSpCas9 | negative selection | 10953167 | 5528378 | 5528401 | 7 | + | 28162770 | OCIAML5 | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | -3.4370290715851533 | [23] | [3] | -9 | hSpCas9 | negative selection | 11122524 | 5528653 | 5528676 | 7 | + | 28162770 | OCIAML5 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.9603194615160204 | [165] | [153] | -6 | hSpCas9 | negative selection | 11122525 | 5529619 | 5529642 | 7 | + | 28162770 | OCIAML5 | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -1.5117264388627543 | [108] | [68] | -7 | hSpCas9 | negative selection | 11122526 | 5529160 | 5529183 | 7 | - | 28162770 | OCIAML5 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -3.1873530486063784 | [216] | [42] | -9 | hSpCas9 | negative selection | 11122527 | 5528675 | 5528698 | 7 | + | 28162770 | OCIAML5 | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -5.37562852692101 | [91] | [3] | -9 | hSpCas9 | negative selection | 11122528 | 5528401 | 5528424 | 7 | - | 28162770 | OCIAML5 | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | -0.4114939794780157 | [41] | [56] | -3 | hSpCas9 | negative selection | 11122529 | 5528267 | 5528290 | 7 | + | 28162770 | OCIAML5 | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -3.1039849445036167 | [180] | [37] | -9 | hSpCas9 | negative selection | 11122530 | 5529525 | 5529548 | 7 | + | 28162770 | OCIAML5 | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | -2.5610177888606067 | [84] | [25] | -8 | hSpCas9 | negative selection | 11122531 | 5529388 | 5529411 | 7 | - | 28162770 | OCIAML5 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.027153277422088395 | [174] | [309] | 0 | hSpCas9 | negative selection | 11122532 | 5529266 | 5529289 | 7 | - | 28162770 | OCIAML5 | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | -2.5669093541320627 | [150] | [45] | -8 | hSpCas9 | negative selection | 11122533 | 5528378 | 5528401 | 7 | + | 28162770 | EOL1 | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | -1.1730630250558876 | [106] | [24] | -7 | hSpCas9 | negative selection | 11291890 | 5528653 | 5528676 | 7 | + | 28162770 | EOL1 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | 0.0354083609201004 | [312] | [168] | 0 | hSpCas9 | negative selection | 11291891 | 5529619 | 5529642 | 7 | + | 28162770 | EOL1 | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | 0.09386774258213465 | [264] | [148] | 0 | hSpCas9 | negative selection | 11291892 | 5529160 | 5529183 | 7 | - | 28162770 | EOL1 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.7779082921690623 | [715] | [219] | -5 | hSpCas9 | negative selection | 11291893 | 5528675 | 5528698 | 7 | + | 28162770 | EOL1 | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -0.08572056388329245 | [281] | [139] | 0 | hSpCas9 | negative selection | 11291894 | 5528401 | 5528424 | 7 | - | 28162770 | EOL1 | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | -1.6932046642682914 | [177] | [28] | -8 | hSpCas9 | negative selection | 11291895 | 5528267 | 5528290 | 7 | + | 28162770 | EOL1 | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -0.2687961172554148 | [294] | [128] | -2 | hSpCas9 | negative selection | 11291896 | 5529525 | 5529548 | 7 | + | 28162770 | EOL1 | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | -0.46776965120822567 | [209] | [79] | -3 | hSpCas9 | negative selection | 11291897 | 5529388 | 5529411 | 7 | - | 28162770 | EOL1 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -1.1909294458494013 | [337] | [77] | -7 | hSpCas9 | negative selection | 11291898 | 5529266 | 5529289 | 7 | - | 28162770 | EOL1 | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | -0.18032134628342036 | [270] | [125] | -1 | hSpCas9 | negative selection | 11291899 | 5528378 | 5528401 | 7 | + | 28162770 | MOLM13 | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | 0.275244303602183 | [87] | [76] | 2 | hSpCas9 | negative selection | 11461256 | 5528653 | 5528676 | 7 | + | 28162770 | MOLM13 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -3.0848927134274273 | [398] | [33] | -8 | hSpCas9 | negative selection | 11461257 | 5529619 | 5529642 | 7 | + | 28162770 | MOLM13 | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -0.12534073516017774 | [174] | [115] | -1 | hSpCas9 | negative selection | 11461258 | 5529160 | 5529183 | 7 | - | 28162770 | MOLM13 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -1.9488978996842248 | [549] | [102] | -7 | hSpCas9 | negative selection | 11461259 | 5528675 | 5528698 | 7 | + | 28162770 | MOLM13 | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -2.7478393095108586 | [287] | [30] | -8 | hSpCas9 | negative selection | 11461260 | 5528401 | 5528424 | 7 | - | 28162770 | MOLM13 | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | -1.7545030397918693 | [167] | [35] | -7 | hSpCas9 | negative selection | 11461261 | 5528267 | 5528290 | 7 | + | 28162770 | MOLM13 | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -3.221770497843271 | [399] | [30] | -8 | hSpCas9 | negative selection | 11461262 | 5529525 | 5529548 | 7 | + | 28162770 | MOLM13 | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | -2.0575721074279154 | [189] | [32] | -7 | hSpCas9 | negative selection | 11461263 | 5529388 | 5529411 | 7 | - | 28162770 | MOLM13 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.8518998025864486 | [336] | [134] | -5 | hSpCas9 | negative selection | 11461264 | 5529266 | 5529289 | 7 | - | 28162770 | MOLM13 | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | -3.0511851835201202 | [320] | [27] | -8 | hSpCas9 | negative selection | 11461265 | 5528378 | 5528401 | 7 | + | 28162770 | HEL | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | -0.8856401403544318 | [74] | [25] | -5 | hSpCas9 | negative selection | 11630622 | 5528653 | 5528676 | 7 | + | 28162770 | HEL | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.4424285512623203 | [313] | [73] | -7 | hSpCas9 | negative selection | 11630623 | 5529619 | 5529642 | 7 | + | 28162770 | HEL | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -0.3230454526617299 | [124] | [63] | -2 | hSpCas9 | negative selection | 11630624 | 5529160 | 5529183 | 7 | - | 28162770 | HEL | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.7298634009580904 | [535] | [206] | -5 | hSpCas9 | negative selection | 11630625 | 5528675 | 5528698 | 7 | + | 28162770 | HEL | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -1.4432343911094958 | [241] | [56] | -7 | hSpCas9 | negative selection | 11630626 | 5528401 | 5528424 | 7 | - | 28162770 | HEL | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | -1.4161548570532116 | [124] | [29] | -7 | hSpCas9 | negative selection | 11630627 | 5528267 | 5528290 | 7 | + | 28162770 | HEL | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -2.8030609210491737 | [315] | [28] | -8 | hSpCas9 | negative selection | 11630628 | 5529525 | 5529548 | 7 | + | 28162770 | HEL | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | -1.1139900169872792 | [195] | [57] | -6 | hSpCas9 | negative selection | 11630629 | 5529388 | 5529411 | 7 | - | 28162770 | HEL | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.14180146082507977 | [297] | [172] | -1 | hSpCas9 | negative selection | 11630630 | 5529266 | 5529289 | 7 | - | 28162770 | HEL | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | 0.036758550010117894 | [241] | [158] | 0 | hSpCas9 | negative selection | 11630631 | 5528378 | 5528401 | 7 | + | 28162770 | MV411 | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | -1.1825502899620397 | [96] | [35] | -6 | hSpCas9 | negative selection | 11799988 | 5528653 | 5528676 | 7 | + | 28162770 | MV411 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -1.2948204989841425 | [232] | [79] | -7 | hSpCas9 | negative selection | 11799989 | 5529619 | 5529642 | 7 | + | 28162770 | MV411 | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -0.9877789109112559 | [112] | [47] | -6 | hSpCas9 | negative selection | 11799990 | 5529160 | 5529183 | 7 | - | 28162770 | MV411 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -1.739962412437591 | [455] | [114] | -8 | hSpCas9 | negative selection | 11799991 | 5528675 | 5528698 | 7 | + | 28162770 | MV411 | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -3.9135543258895296 | [160] | [8] | -9 | hSpCas9 | negative selection | 11799992 | 5528401 | 5528424 | 7 | - | 28162770 | MV411 | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | -0.3787476126648939 | [70] | [45] | -3 | hSpCas9 | negative selection | 11799993 | 5528267 | 5528290 | 7 | + | 28162770 | MV411 | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -0.7917330464979025 | [223] | [108] | -5 | hSpCas9 | negative selection | 11799994 | 5529525 | 5529548 | 7 | + | 28162770 | MV411 | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | -0.5566422392419679 | [109] | [62] | -4 | hSpCas9 | negative selection | 11799995 | 5529388 | 5529411 | 7 | - | 28162770 | MV411 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.29419751827428015 | [245] | [168] | -2 | hSpCas9 | negative selection | 11799996 | 5529266 | 5529289 | 7 | - | 28162770 | MV411 | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | -0.3221769856049449 | [186] | [125] | -2 | hSpCas9 | negative selection | 11799997 | 5528378 | 5528401 | 7 | + | 28162770 | MONOMAC1 | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | -1.0860055346708097 | [49] | [26] | -7 | hSpCas9 | negative selection | 11969354 | 5528653 | 5528676 | 7 | + | 28162770 | MONOMAC1 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.8505864330381223 | [139] | [88] | -6 | hSpCas9 | negative selection | 11969355 | 5529619 | 5529642 | 7 | + | 28162770 | MONOMAC1 | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -5.139551352398794 | [122] | [3] | -9 | hSpCas9 | negative selection | 11969356 | 5529160 | 5529183 | 7 | - | 28162770 | MONOMAC1 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -3.021006482968054 | [261] | [36] | -9 | hSpCas9 | negative selection | 11969357 | 5528675 | 5528698 | 7 | + | 28162770 | MONOMAC1 | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -4.1039274426680725 | [119] | [7] | -9 | hSpCas9 | negative selection | 11969358 | 5528401 | 5528424 | 7 | - | 28162770 | MONOMAC1 | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | -2.3294871430832034 | [56] | [12] | -9 | hSpCas9 | negative selection | 11969359 | 5528267 | 5528290 | 7 | + | 28162770 | MONOMAC1 | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -3.012953782620582 | [168] | [23] | -9 | hSpCas9 | negative selection | 11969360 | 5529525 | 5529548 | 7 | + | 28162770 | MONOMAC1 | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | -2.0180667060142343 | [52] | [14] | -8 | hSpCas9 | negative selection | 11969361 | 5529388 | 5529411 | 7 | - | 28162770 | MONOMAC1 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -2.319893594845087 | [195] | [44] | -9 | hSpCas9 | negative selection | 11969362 | 5529266 | 5529289 | 7 | - | 28162770 | MONOMAC1 | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | -1.7589157346676687 | [123] | [41] | -8 | hSpCas9 | negative selection | 11969363 | 5528378 | 5528401 | 7 | + | 28162770 | OCIAML2 | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | -1.608133348992096 | [21] | [39] | -7 | hSpCas9 | negative selection | 12138720 | 5528653 | 5528676 | 7 | + | 28162770 | OCIAML2 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.4321556774275256 | [36] | [151] | -3 | hSpCas9 | negative selection | 12138721 | 5529619 | 5529642 | 7 | + | 28162770 | OCIAML2 | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -0.037670417966055136 | [24] | [134] | 0 | hSpCas9 | negative selection | 12138722 | 5529160 | 5529183 | 7 | - | 28162770 | OCIAML2 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -0.6662649457903687 | [68] | [240] | -5 | hSpCas9 | negative selection | 12138723 | 5528675 | 5528698 | 7 | + | 28162770 | OCIAML2 | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -1.4064994878224455 | [21] | [45] | -7 | hSpCas9 | negative selection | 12138724 | 5528401 | 5528424 | 7 | - | 28162770 | OCIAML2 | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | 0.8704070925929059 | [14] | [151] | 8 | hSpCas9 | negative selection | 12138725 | 5528267 | 5528290 | 7 | + | 28162770 | OCIAML2 | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -1.651202070883982 | [33] | [59] | -7 | hSpCas9 | negative selection | 12138726 | 5529525 | 5529548 | 7 | + | 28162770 | OCIAML2 | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | -2.2877657680923504 | [36] | [41] | -8 | hSpCas9 | negative selection | 12138727 | 5529388 | 5529411 | 7 | - | 28162770 | OCIAML2 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | -0.6405548266844738 | [44] | [159] | -5 | hSpCas9 | negative selection | 12138728 | 5529266 | 5529289 | 7 | - | 28162770 | OCIAML2 | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | -0.38764046057112955 | [37] | [160] | -3 | hSpCas9 | negative selection | 12138729 | 5528378 | 5528401 | 7 | + | 28162770 | OCIAML3 | viability | GGAGGAGCTGGAAGCAGCCGTGG | ACTB | ENSG00000075624 | -0.8164000616606111 | [13] | [23] | -6 | hSpCas9 | negative selection | 12308086 | 5528653 | 5528676 | 7 | + | 28162770 | OCIAML3 | viability | CGTACAGGGATAGCACAGCCTGG | ACTB | ENSG00000075624 | -0.16683638540946416 | [73] | [198] | -1 | hSpCas9 | negative selection | 12308087 | 5529619 | 5529642 | 7 | + | 28162770 | OCIAML3 | viability | GCCGTTGTCGACGACGAGCGCGG | ACTB | ENSG00000075624 | -0.9310426276017337 | [35] | [56] | -6 | hSpCas9 | negative selection | 12308088 | 5529160 | 5529183 | 7 | - | 28162770 | OCIAML3 | viability | CAACCGCGAGAAGATGACCCAGG | ACTB | ENSG00000075624 | -1.1051211111580548 | [118] | [166] | -7 | hSpCas9 | negative selection | 12308089 | 5528675 | 5528698 | 7 | + | 28162770 | OCIAML3 | viability | GATAGCAACGTACATGGCTGGGG | ACTB | ENSG00000075624 | -1.5173863587212508 | [54] | [57] | -8 | hSpCas9 | negative selection | 12308090 | 5528401 | 5528424 | 7 | - | 28162770 | OCIAML3 | viability | CCTGGACTTCGAGCAAGAGATGG | ACTB | ENSG00000075624 | -1.2552057268724046 | [33] | [42] | -7 | hSpCas9 | negative selection | 12308091 | 5528267 | 5528290 | 7 | + | 28162770 | OCIAML3 | viability | CAGTCTCCACTCACCCAGGAAGG | ACTB | ENSG00000075624 | -1.4013625623817672 | [69] | [79] | -7 | hSpCas9 | negative selection | 12308092 | 5529525 | 5529548 | 7 | + | 28162770 | OCIAML3 | viability | GCTCCCCTACCTGGTGCCTGGGG | ACTB | ENSG00000075624 | -0.9310426276017337 | [35] | [56] | -6 | hSpCas9 | negative selection | 12308093 | 5529388 | 5529411 | 7 | - | 28162770 | OCIAML3 | viability | TCCTTCCCAGGGCGTGATGGTGG | ACTB | ENSG00000075624 | 0.07918204340872842 | [73] | [235] | 0 | hSpCas9 | negative selection | 12308094 | 5529266 | 5529289 | 7 | - | 28162770 | OCIAML3 | viability | GGGACGACATGGAGAAAATCTGG | ACTB | ENSG00000075624 | -0.03879248299705901 | [48] | [143] | 0 | hSpCas9 | negative selection | 12308095 |