Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:70
• Symbol:ACTC1
• Description:actin alpha cardiac muscle 1

DataSource: http://genomecrispr.dkfz.de/#!/results/ACTC1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
34793282	34793305	15	+	26472758	Jiyoye	viability	CTGGATGGCCACGTACATGGCAG	ACTC1	ENSG00000159251	0.8062713369156956	[90]	[119]	5	hSpCas9	negative selection	1997
34794767	34794790	15	+	26472758	Jiyoye	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	0.810897567556883	[95]	[126]	5	hSpCas9	negative selection	2032
34792545	34792568	15	-	26472758	Jiyoye	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	-0.06531238995687028	[110]	[79]	0	hSpCas9	negative selection	2033
34794701	34794724	15	+	26472758	Jiyoye	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	0.3627812621474198	[32]	[31]	2	hSpCas9	negative selection	2034
34791158	34791181	15	+	26472758	Jiyoye	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	0.548037917345723	[77]	[85]	4	hSpCas9	negative selection	2035
34794669	34794692	15	+	26472758	Jiyoye	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.579128064295168	[157]	[177]	4	hSpCas9	negative selection	2036
34793284	34793307	15	+	26472758	Jiyoye	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-0.7111445856828877	[253]	[116]	-5	hSpCas9	negative selection	2037
34792105	34792128	15	+	26472758	Jiyoye	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	-0.2708965236067642	[47]	[29]	-2	hSpCas9	negative selection	2038
34791224	34791247	15	-	26472758	Jiyoye	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.2521445953632553	[264]	[237]	2	hSpCas9	negative selection	2039
34794754	34794777	15	-	26472758	Jiyoye	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	1.8608933489487773	[22]	[62]	8	hSpCas9	negative selection	2040
34793249	34793272	15	+	26472758	Jiyoye	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	1.111932394761744	[153]	[250]	7	hSpCas9	negative selection	2041
34793282	34793305	15	+	26472758	KBM7	viability	CTGGATGGCCACGTACATGGCAG	ACTC1	ENSG00000159251	-0.015155583855530674	[615,655]	[301,294]	0	hSpCas9	negative selection	193115
34794767	34794790	15	+	26472758	KBM7	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	0.26670586841705	[656,508]	[428,235]	2	hSpCas9	negative selection	193150
34792545	34792568	15	-	26472758	KBM7	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	0.9201500479074485	[207,289]	[247,206]	8	hSpCas9	negative selection	193151
34794701	34794724	15	+	26472758	KBM7	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	-0.5207258766374888	[472,491]	[173,145]	-4	hSpCas9	negative selection	193152
34791158	34791181	15	+	26472758	KBM7	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	0.9640739230590663	[350,310]	[421,196]	9	hSpCas9	negative selection	193153
34794669	34794692	15	+	26472758	KBM7	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.5592584447568364	[850,575]	[590,393]	6	hSpCas9	negative selection	193154
34793284	34793307	15	+	26472758	KBM7	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-0.1761343047465288	[845,954]	[314,435]	-2	hSpCas9	negative selection	193155
34792105	34792128	15	+	26472758	KBM7	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	-1.0192270114016702	[185,279]	[18,87]	-7	hSpCas9	negative selection	193156
34791224	34791247	15	-	26472758	KBM7	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.2295491630676627	[1556,1478]	[711,951]	2	hSpCas9	negative selection	193157
34794754	34794777	15	-	26472758	KBM7	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	0.8801499687289619	[289,433]	[298,340]	8	hSpCas9	negative selection	193158
34793249	34793272	15	+	26472758	KBM7	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.4281523068326769	[1079,1260]	[778,723]	4	hSpCas9	negative selection	193159
34793282	34793305	15	+	26472758	Raji	viability	CTGGATGGCCACGTACATGGCAG	ACTC1	ENSG00000159251	0.15765674185482342	[281]	[72]	1	hSpCas9	negative selection	384233
34794767	34794790	15	+	26472758	Raji	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	0.15800960844356737	[223]	[57]	1	hSpCas9	negative selection	384268
34792545	34792568	15	-	26472758	Raji	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	-0.46307939565244166	[296]	[49]	-4	hSpCas9	negative selection	384269
34794701	34794724	15	+	26472758	Raji	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	-0.6999713866840043	[90]	[12]	-5	hSpCas9	negative selection	384270
34791158	34791181	15	+	26472758	Raji	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	0.5354771874778896	[109]	[36]	5	hSpCas9	negative selection	384271
34794669	34794692	15	+	26472758	Raji	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.35770688945783946	[379]	[112]	3	hSpCas9	negative selection	384272
34793284	34793307	15	+	26472758	Raji	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-0.7903178887802585	[312]	[41]	-6	hSpCas9	negative selection	384273
34792105	34792128	15	+	26472758	Raji	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	-1.4846337228815072	[204]	[16]	-8	hSpCas9	negative selection	384274
34791224	34791247	15	-	26472758	Raji	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.07417648998368054	[834]	[203]	0	hSpCas9	negative selection	384275
34794754	34794777	15	-	26472758	Raji	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	-0.31792229935907135	[187]	[34]	-3	hSpCas9	negative selection	384276
34793249	34793272	15	+	26472758	Raji	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.3779124777543177	[639]	[192]	3	hSpCas9	negative selection	384277
34793282	34793305	15	+	26472758	K562	viability	CTGGATGGCCACGTACATGGCAG	ACTC1	ENSG00000159251	0.9864821894723319	[451]	[755]	8	hSpCas9	negative selection	575351
34794767	34794790	15	+	26472758	K562	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	0.5405068176185497	[337]	[414]	4	hSpCas9	negative selection	575386
34792545	34792568	15	-	26472758	K562	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	0.3470232129007981	[406]	[436]	2	hSpCas9	negative selection	575387
34794701	34794724	15	+	26472758	K562	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	-0.9110988499548399	[273]	[122]	-5	hSpCas9	negative selection	575388
34791158	34791181	15	+	26472758	K562	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	0.7597757609017363	[183]	[262]	6	hSpCas9	negative selection	575389
34794669	34794692	15	+	26472758	K562	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.3033124167200154	[575]	[599]	2	hSpCas9	negative selection	575390
34793284	34793307	15	+	26472758	K562	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-2.357031895843278	[879]	[144]	-8	hSpCas9	negative selection	575391
34792105	34792128	15	+	26472758	K562	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	-2.0826526704968753	[280]	[55]	-7	hSpCas9	negative selection	575392
34791224	34791247	15	-	26472758	K562	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.7656313284578007	[1148]	[1648]	6	hSpCas9	negative selection	575393
34794754	34794777	15	-	26472758	K562	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	1.5946050825953226	[272]	[695]	9	hSpCas9	negative selection	575394
34793249	34793272	15	+	26472758	K562	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.6489187727112773	[1167]	[1545]	5	hSpCas9	negative selection	575395
34792079	34792102	15	+	26627737	DLD1	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.38574509462107975	[591]	[333,272,135]	4	hSpCas9	negative selection	790284
34792400	34792423	15	+	26627737	DLD1	viability	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	-0.5236915622141706	[1021]	[207,211,242]	-5	hSpCas9	negative selection	790285
34794669	34794692	15	+	26627737	DLD1	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-0.5281049036901414	[290]	[75,103,17]	-5	hSpCas9	negative selection	790286
34794673	34794696	15	+	26627737	DLD1	viability	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.9103581944635858	[228]	[87,166,147]	8	hSpCas9	negative selection	790287
34794793	34794816	15	-	26627737	DLD1	viability	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	-0.293849872184911	[1859]	[625,409,395]	-3	hSpCas9	negative selection	790288
34792079	34792102	15	+	26627737	GBM cells	viability after 5 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.03506066241872019	[676]	[368,374]	0	hSpCas9	negative selection	872599
34792400	34792423	15	+	26627737	GBM cells	viability after 5 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	-0.28615533211630517	[406]	[169,187]	-4	hSpCas9	negative selection	872600
34794669	34794692	15	+	26627737	GBM cells	viability after 5 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.38626557898041924	[106]	[79,69]	6	hSpCas9	negative selection	872601
34794673	34794696	15	+	26627737	GBM cells	viability after 5 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.6556427238733218	[115]	[121,73]	8	hSpCas9	negative selection	872602
34794793	34794816	15	-	26627737	GBM cells	viability after 5 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	0.32416518702652874	[562]	[426,328]	5	hSpCas9	negative selection	872603
34792079	34792102	15	+	26627737	GBM cells	viability after 13 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.0909566998362712	[676]	[436,353]	1	hSpCas9	negative selection	954914
34792400	34792423	15	+	26627737	GBM cells	viability after 13 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	-0.08552636924768064	[406]	[238,182]	-1	hSpCas9	negative selection	954915
34794669	34794692	15	+	26627737	GBM cells	viability after 13 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.9684925136060604	[106]	[74,144]	9	hSpCas9	negative selection	954916
34794673	34794696	15	+	26627737	GBM cells	viability after 13 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.8141351537349629	[115]	[124,98]	8	hSpCas9	negative selection	954917
34794793	34794816	15	-	26627737	GBM cells	viability after 13 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	0.5127609682855385	[562]	[458,416]	6	hSpCas9	negative selection	954918
34792079	34792102	15	+	26627737	GBM cells	viability after 21 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.3265047354221726	[676]	[467,454]	3	hSpCas9	negative selection	1037229
34792400	34792423	15	+	26627737	GBM cells	viability after 21 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	0.1582870715979976	[406]	[275,219]	1	hSpCas9	negative selection	1037230
34794669	34794692	15	+	26627737	GBM cells	viability after 21 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	1.0190981133711874	[106]	[133,102]	8	hSpCas9	negative selection	1037231
34794673	34794696	15	+	26627737	GBM cells	viability after 21 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	1.050281130655839	[115]	[141,119]	9	hSpCas9	negative selection	1037232
34794793	34794816	15	-	26627737	GBM cells	viability after 21 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	1.086970770483636	[562]	[690,611]	9	hSpCas9	negative selection	1037233
34792079	34792102	15	+	26627737	RPE1	viability after 9 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	1.0675313052100208	[1147]	[661,870]	6	hSpCas9	negative selection	1119544
34792400	34792423	15	+	26627737	RPE1	viability after 9 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	0.49135294066594587	[970]	[284,610]	3	hSpCas9	negative selection	1119545
34794669	34794692	15	+	26627737	RPE1	viability after 9 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.0745594010456338	[960]	[163,513]	0	hSpCas9	negative selection	1119546
34794673	34794696	15	+	26627737	RPE1	viability after 9 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	3.0931485214339904	[59]	[89,250]	9	hSpCas9	negative selection	1119547
34794793	34794816	15	-	26627737	RPE1	viability after 9 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	1.1007622657680074	[1702]	[1366,854]	6	hSpCas9	negative selection	1119548
34792079	34792102	15	+	26627737	RPE1	viability after 12 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	1.0266782589761967	[1147]	[538,722]	6	hSpCas9	negative selection	1201859
34792400	34792423	15	+	26627737	RPE1	viability after 12 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	0.9331169035370834	[970]	[382,619]	6	hSpCas9	negative selection	1201860
34794669	34794692	15	+	26627737	RPE1	viability after 12 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.14917463639376888	[960]	[245,328]	1	hSpCas9	negative selection	1201861
34794673	34794696	15	+	26627737	RPE1	viability after 12 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	3.228989806121041	[59]	[121,181]	9	hSpCas9	negative selection	1201862
34794793	34794816	15	-	26627737	RPE1	viability after 12 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	1.2120583542622845	[1702]	[1194,916]	7	hSpCas9	negative selection	1201863
34792079	34792102	15	+	26627737	RPE1	viability after 15 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.7337965604498187	[1147]	[508,569]	4	hSpCas9	negative selection	1284174
34792400	34792423	15	+	26627737	RPE1	viability after 15 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	0.5088784191093227	[970]	[286,490]	3	hSpCas9	negative selection	1284175
34794669	34794692	15	+	26627737	RPE1	viability after 15 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.22386622744337753	[960]	[374,261]	1	hSpCas9	negative selection	1284176
34794673	34794696	15	+	26627737	RPE1	viability after 15 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	3.484146867151802	[59]	[165,212]	9	hSpCas9	negative selection	1284177
34794793	34794816	15	-	26627737	RPE1	viability after 15 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	0.9627423584287265	[1702]	[1280,608]	6	hSpCas9	negative selection	1284178
34792079	34792102	15	+	26627737	RPE1	viability after 18 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.9927128724666643	[1147]	[528,709]	6	hSpCas9	negative selection	1366489
34792400	34792423	15	+	26627737	RPE1	viability after 18 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	0.7575653993174931	[970]	[326,566]	4	hSpCas9	negative selection	1366490
34794669	34794692	15	+	26627737	RPE1	viability after 18 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.3861750496896647	[960]	[380,293]	2	hSpCas9	negative selection	1366491
34794673	34794696	15	+	26627737	RPE1	viability after 18 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	3.2514277512471716	[59]	[159,147]	9	hSpCas9	negative selection	1366492
34794793	34794816	15	-	26627737	RPE1	viability after 18 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	1.2837876407619289	[1702]	[1380,838]	7	hSpCas9	negative selection	1366493
34792079	34792102	15	+	26627737	HeLa	viability after 8 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.06076485975411583	[793]	[593,191,269]	0	hSpCas9	negative selection	1448804
34792400	34792423	15	+	26627737	HeLa	viability after 8 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	-1.2705902510063285	[686]	[162,58,155]	-8	hSpCas9	negative selection	1448805
34794669	34794692	15	+	26627737	HeLa	viability after 8 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-0.2793828741576775	[208]	[104,74,52]	-3	hSpCas9	negative selection	1448806
34794673	34794696	15	+	26627737	HeLa	viability after 8 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	1.3749843419357226	[105]	[140,108,113]	8	hSpCas9	negative selection	1448807
34794793	34794816	15	-	26627737	HeLa	viability after 8 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	0.6999471665359818	[867]	[508,670,635]	6	hSpCas9	negative selection	1448808
34792079	34792102	15	+	26627737	HeLa	viability after 12 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.19598026437860494	[793]	[196,387,260]	-2	hSpCas9	negative selection	1531119
34792400	34792423	15	+	26627737	HeLa	viability after 12 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	-0.6888147625507628	[686]	[118,182,223]	-6	hSpCas9	negative selection	1531120
34794669	34794692	15	+	26627737	HeLa	viability after 12 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-0.41406277515299805	[208]	[31,97,59]	-4	hSpCas9	negative selection	1531121
34794673	34794696	15	+	26627737	HeLa	viability after 12 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	1.1558442445869215	[105]	[194,65,37]	8	hSpCas9	negative selection	1531122
34794793	34794816	15	-	26627737	HeLa	viability after 12 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	0.49977436654909746	[867]	[349,441,731]	4	hSpCas9	negative selection	1531123
34792079	34792102	15	+	26627737	HeLa	viability after 15 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.015357278059544788	[793]	[377,279,320]	0	hSpCas9	negative selection	1613434
34792400	34792423	15	+	26627737	HeLa	viability after 15 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	0.08457343977759513	[686]	[348,134,413]	0	hSpCas9	negative selection	1613435
34794669	34794692	15	+	26627737	HeLa	viability after 15 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-0.06712430830539429	[208]	[34,130,77]	0	hSpCas9	negative selection	1613436
34794673	34794696	15	+	26627737	HeLa	viability after 15 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	1.0833365889904771	[105]	[11,175,86]	7	hSpCas9	negative selection	1613437
34794793	34794816	15	-	26627737	HeLa	viability after 15 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	0.7904884092105424	[867]	[414,714,713]	6	hSpCas9	negative selection	1613438
34792079	34792102	15	+	26627737	HeLa	viability after 18 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.008294282242251594	[793]	[239,244,320]	0	hSpCas9	negative selection	1695749
34792400	34792423	15	+	26627737	HeLa	viability after 18 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	0.06545406535286458	[686]	[219,119,413]	0	hSpCas9	negative selection	1695750
34794669	34794692	15	+	26627737	HeLa	viability after 18 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-0.05313730696359875	[208]	[22,110,77]	0	hSpCas9	negative selection	1695751
34794673	34794696	15	+	26627737	HeLa	viability after 18 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	1.0797826843097502	[105]	[8,143,86]	7	hSpCas9	negative selection	1695752
34794793	34794816	15	-	26627737	HeLa	viability after 18 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	0.7673911826204154	[867]	[261,588,713]	6	hSpCas9	negative selection	1695753
34792079	34792102	15	+	26627737	HCT116	viability after 6 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.5885037250970406	[1405]	[274,363]	3	hSpCas9	negative selection	1778064
34792400	34792423	15	+	26627737	HCT116	viability after 6 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	-0.6082741270089781	[1013]	[159,73]	-3	hSpCas9	negative selection	1778065
34794669	34794692	15	+	26627737	HCT116	viability after 6 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-0.27854696919511235	[625]	[220,3]	-1	hSpCas9	negative selection	1778066
34794673	34794696	15	+	26627737	HCT116	viability after 6 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	1.2373970003002954	[423]	[151,159]	6	hSpCas9	negative selection	1778067
34794793	34794816	15	-	26627737	HCT116	viability after 6 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	0.41286120803385895	[1639]	[631,183]	2	hSpCas9	negative selection	1778068
34792079	34792102	15	+	26627737	HCT116	viability after 8 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.45214090286787445	[898]	[327,421,335]	-5	hSpCas9	negative selection	1860379
34792400	34792423	15	+	26627737	HCT116	viability after 8 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	-0.1478440837227898	[459]	[265,190,229]	-2	hSpCas9	negative selection	1860380
34794669	34794692	15	+	26627737	HCT116	viability after 8 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-2.1858659920755024	[302]	[36,28,43]	-9	hSpCas9	negative selection	1860381
34794673	34794696	15	+	26627737	HCT116	viability after 8 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	-0.3146698026873528	[178]	[121,63,52]	-4	hSpCas9	negative selection	1860382
34794793	34794816	15	-	26627737	HCT116	viability after 8 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	-0.08190323964974033	[1022]	[483,670,442]	-1	hSpCas9	negative selection	1860383
34792079	34792102	15	+	26627737	HCT116	viability after 9 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.08989800652797775	[1405]	[316,380]	0	hSpCas9	negative selection	1942694
34792400	34792423	15	+	26627737	HCT116	viability after 9 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	-0.4309001236036687	[1013]	[187,210]	-3	hSpCas9	negative selection	1942695
34794669	34794692	15	+	26627737	HCT116	viability after 9 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-0.6289385857591516	[625]	[173,55]	-4	hSpCas9	negative selection	1942696
34794673	34794696	15	+	26627737	HCT116	viability after 9 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.5626403097749567	[423]	[312,51]	4	hSpCas9	negative selection	1942697
34794793	34794816	15	-	26627737	HCT116	viability after 9 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	0.7700913099680464	[1639]	[762,733]	5	hSpCas9	negative selection	1942698
34792079	34792102	15	+	26627737	HCT116	viability after 12 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.24816987016439307	[898]	[332,395,469]	-3	hSpCas9	negative selection	2025009
34792400	34792423	15	+	26627737	HCT116	viability after 12 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	0.022046439912721816	[459]	[337,151,235]	0	hSpCas9	negative selection	2025010
34794669	34794692	15	+	26627737	HCT116	viability after 12 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-1.164792781471053	[302]	[45,59,108]	-8	hSpCas9	negative selection	2025011
34794673	34794696	15	+	26627737	HCT116	viability after 12 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.24471807486266117	[178]	[110,52,168]	2	hSpCas9	negative selection	2025012
34794793	34794816	15	-	26627737	HCT116	viability after 12 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	0.15126870106374857	[1022]	[394,766,650]	1	hSpCas9	negative selection	2025013
34792079	34792102	15	+	26627737	HCT116	viability after 15 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.2954486506507996	[898]	[326,365,555]	-3	hSpCas9	negative selection	2107324
34792400	34792423	15	+	26627737	HCT116	viability after 15 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	-0.07469513264879701	[459]	[368,236,161]	-1	hSpCas9	negative selection	2107325
34794669	34794692	15	+	26627737	HCT116	viability after 15 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-3.4107963947479085	[302]	[1,0,43]	-9	hSpCas9	negative selection	2107326
34794673	34794696	15	+	26627737	HCT116	viability after 15 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.5282006026674296	[178]	[149,66,226]	5	hSpCas9	negative selection	2107327
34794793	34794816	15	-	26627737	HCT116	viability after 15 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	0.23490606067547493	[1022]	[400,1042,595]	2	hSpCas9	negative selection	2107328
34792079	34792102	15	+	26627737	HCT116	viability after 18 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.028809918340338747	[898]	[257,452,571]	0	hSpCas9	negative selection	2189639
34792400	34792423	15	+	26627737	HCT116	viability after 18 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	-0.21991675697335822	[459]	[184,191,195]	-2	hSpCas9	negative selection	2189640
34794669	34794692	15	+	26627737	HCT116	viability after 18 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-1.6890123032040691	[302]	[21,48,65]	-8	hSpCas9	negative selection	2189641
34794673	34794696	15	+	26627737	HCT116	viability after 18 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.1435047024259145	[178]	[61,55,174]	1	hSpCas9	negative selection	2189642
34794793	34794816	15	-	26627737	HCT116	viability after 18 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	0.26648930009773864	[1022]	[520,562,707]	2	hSpCas9	negative selection	2189643
34795903	34795926	15	+	25494202	A375	resistance to PLX-4720 (puromycin)	CTCCGCAGCCCTGCCAGCCTTGG	ACTC1	ENSG00000159251	-1.0746727243089549	[304,86]	[31,5]	-6	dCas9-VP64	positive selection	2437330
34795791	34795814	15	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGGGAGGGGCAGGCGCTGAAGGG	ACTC1	ENSG00000159251	-0.39515341275964005	[212,31]	[33,3]	-2	dCas9-VP64	positive selection	2437331
34795865	34795888	15	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGGTGTGGGTGCTCCCTGGATGG	ACTC1	ENSG00000159251	-0.1722691275402121	[38,143]	[10,24]	0	dCas9-VP64	positive selection	2437332
34795903	34795926	15	+	25494202	A375	resistance to PLX-4720 (zeocin)	CTCCGCAGCCCTGCCAGCCTTGG	ACTC1	ENSG00000159251	-0.6870909453147389	[281,140]	[43,41]	-6	dCas9-VP64	positive selection	2532585
34795791	34795814	15	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGGGAGGGGCAGGCGCTGAAGGG	ACTC1	ENSG00000159251	0.4660194602812794	[52,64]	[25,25]	3	dCas9-VP64	positive selection	2532586
34795865	34795888	15	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGGTGTGGGTGCTCCCTGGATGG	ACTC1	ENSG00000159251	-1.371332220765396	[250,50]	[22,14]	-9	dCas9-VP64	positive selection	2532587
34794701	34794724	15	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CGATGGACGGGAAGACAGCGCGG	ACTC1	ENSG00000159251	-0.5956682134461766	[2,2]	[1,0]	-7	hSpCas9	positive selection	2968686
34793250	34793273	15	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.42882643816956273	[3,3]	[3,4]	8	hSpCas9	positive selection	2968687
34793390	34793413	15	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGTGCTCCTCGGGAGCCACACGG	ACTC1	ENSG00000159251	-0.10343119755141579	[3,3]	[2,2]	-1	hSpCas9	positive selection	2968688
34793349	34793372	15	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTTGGCCTTGGGGTTCAGCGGGG	ACTC1	ENSG00000159251	-0.3631179110229183	[3,3]	[1,1]	-5	hSpCas9	positive selection	2968689
34794701	34794724	15	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CGATGGACGGGAAGACAGCGCGG	ACTC1	ENSG00000159251	-0.2055471151262574	[2,2]	[0,1]	-3	hSpCas9	positive selection	3036544
34793250	34793273	15	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	-0.6989560152292386	[3,3]	[2,0]	-8	hSpCas9	positive selection	3036545
34793390	34793413	15	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGTGCTCCTCGGGAGCCACACGG	ACTC1	ENSG00000159251	0.10506415565461161	[3,3]	[2,2]	1	hSpCas9	positive selection	3036546
34793349	34793372	15	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTTGGCCTTGGGGTTCAGCGGGG	ACTC1	ENSG00000159251	-0.37980136814609866	[3,3]	[2,0]	-5	hSpCas9	positive selection	3036547
34792135	34792158		+	24336571	A375	resistance to PLX after 7 days	CATTGCCAATAGTGATGACTTGG	ACTC1	ENSG00000159251	-0.3451899540555047	[27,25]	[19,21]	-8	hSpCas9	positive selection	3159691
34792079	34792102		+	24336571	A375	resistance to PLX after 7 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.38084563790995424	[9,10]	[7,7]	-9	hSpCas9	positive selection	3159701
34793557	34793580		-	24336571	A375	resistance to PLX after 7 days	CTTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	0.07731724606678247	[7,6]	[7,7]	2	hSpCas9	positive selection	3159707
34793248	34793271		+	24336571	A375	resistance to PLX after 7 days	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.15635405912440647	[12,10]	[12,12]	5	hSpCas9	positive selection	3159715
34792135	34792158		+	24336571	A375	resistance to PLX after 14 days	CATTGCCAATAGTGATGACTTGG	ACTC1	ENSG00000159251	-0.49024671102037964	[33,20]	[8,8]	-6	hSpCas9	positive selection	3217484
34792079	34792102		+	24336571	A375	resistance to PLX after 14 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.7233460650181408	[7,6]	[5,4]	6	hSpCas9	positive selection	3217494
34793557	34793580		-	24336571	A375	resistance to PLX after 14 days	CTTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	-0.16475420864984613	[7,4]	[1,1]	-2	hSpCas9	positive selection	3217500
34793248	34793271		+	24336571	A375	resistance to PLX after 14 days	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	-0.28051282687728957	[10,6]	[2,2]	-3	hSpCas9	positive selection	3217508
34792135	34792158		+	24336571	A375	viability after 7 days	CATTGCCAATAGTGATGACTTGG	ACTC1	ENSG00000159251	0.42419733673973503	[20]	[27,25]	6	hSpCas9	negative selection	3275277
34792079	34792102		+	24336571	A375	viability after 7 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.38579299599837336	[13]	[9,10]	-5	hSpCas9	negative selection	3275287
34793557	34793580		-	24336571	A375	viability after 7 days	CTTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	0.1162093744153414	[6]	[7,6]	1	hSpCas9	negative selection	3275293
34793248	34793271		+	24336571	A375	viability after 7 days	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.07964278506451192	[11]	[12,10]	1	hSpCas9	negative selection	3275301
34792135	34792158		+	24336571	A375	viability after 14 days	CATTGCCAATAGTGATGACTTGG	ACTC1	ENSG00000159251	0.4654142435951095	[20]	[33,20]	6	hSpCas9	negative selection	3333070
34792079	34792102		+	24336571	A375	viability after 14 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.7998374717245024	[13]	[7,6]	-7	hSpCas9	negative selection	3333080
34793557	34793580		-	24336571	A375	viability after 14 days	CTTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	-0.08957922355098613	[6]	[7,4]	-1	hSpCas9	negative selection	3333086
34793248	34793271		+	24336571	A375	viability after 14 days	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	-0.28657754796355717	[11]	[10,6]	-3	hSpCas9	negative selection	3333094
34792558	34792581	15	-	27383988	293T	resistance to West Nile virus (flavivirus)	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.21916033491057468	[120,141]	[0,0]	1	hSpCas9	positive selection	3335394
34791157	34791180	15	+	27383988	293T	resistance to West Nile virus (flavivirus)	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.39583499179323883	[245,155]	[0,0]	-2	hSpCas9	positive selection	3335395
34793248	34793271	15	+	27383988	293T	resistance to West Nile virus (flavivirus)	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.4900937893786537	[97,119]	[0,0]	2	hSpCas9	positive selection	3335396
34791224	34791247	15	-	27383988	293T	resistance to West Nile virus (flavivirus)	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.2662357446111776	[183,183]	[0,0]	-2	hSpCas9	positive selection	3354643
34792079	34792102	15	+	27383988	293T	resistance to West Nile virus (flavivirus)	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.47596649792117546	[109,109]	[0,0]	2	hSpCas9	positive selection	3354644
34793256	34793279	15	-	27383988	293T	resistance to West Nile virus (flavivirus)	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-1.3610592908127714	[392,392]	[0,0]	-8	hSpCas9	positive selection	3354645
34794700	34794723	15	+	26780180	HT29	viability (Avana library 4 designs)	CGATGGACGGGAAGACAGCGCGG	ACTC1	ENSG00000159251	0.777975051670391	[]	[]	3	hSpCas9	negative selection	3404634
34793249	34793272	15	+	26780180	HT29	viability (Avana library 4 designs)	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.941789230367371	[]	[]	3	hSpCas9	negative selection	3404635
34793389	34793412	15	+	26780180	HT29	viability (Avana library 4 designs)	GGTGCTCCTCGGGAGCCACACGG	ACTC1	ENSG00000159251	0.302843706533563	[]	[]	1	hSpCas9	negative selection	3404636
34793348	34793371	15	+	26780180	HT29	viability (Avana library 4 designs)	GTTGGCCTTGGGGTTCAGCGGGG	ACTC1	ENSG00000159251	2.27508084667757	[]	[]	7	hSpCas9	negative selection	3404637
34793389	34793412	15	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGTGCTCCTCGGGAGCCACACGG	ACTC1	ENSG00000159251	6.50627438186516	[]	[]	9	hSpCas9	negative selection	3476267
34793348	34793371	15	+	26780180	A375	viability (Avana lentiCRISPRv2)	GTTGGCCTTGGGGTTCAGCGGGG	ACTC1	ENSG00000159251	3.31160908120231	[]	[]	5	hSpCas9	negative selection	3476268
34793249	34793272	15	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	4.60991077019527	[]	[]	7	hSpCas9	negative selection	3476269
34794700	34794723	15	+	26780180	A375	viability (Avana lentiCRISPRv2)	CGATGGACGGGAAGACAGCGCGG	ACTC1	ENSG00000159251	3.92916737837614	[]	[]	6	hSpCas9	negative selection	3476270
34794764	34794787	15	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCCGTTGTCGCACACCAGGGCGG	ACTC1	ENSG00000159251	2.65763475361433	[]	[]	4	hSpCas9	negative selection	3476271
34794761	34794784	15	+	26780180	A375	viability (Avana lentiCRISPRv2)	AGAGCCGTTGTCGCACACCAGGG	ACTC1	ENSG00000159251	-1.48217464069113	[]	[]	-2	hSpCas9	negative selection	3476272
34793389	34793412	15	+	26780180	A375	viability (Avana lentiGuide)	GGTGCTCCTCGGGAGCCACACGG	ACTC1	ENSG00000159251	-4.05080366153474	[]	[]	-7	hSpCas9	negative selection	3584926
34793348	34793371	15	+	26780180	A375	viability (Avana lentiGuide)	GTTGGCCTTGGGGTTCAGCGGGG	ACTC1	ENSG00000159251	17.5665323019624	[]	[]	8	hSpCas9	negative selection	3584927
34793249	34793272	15	+	26780180	A375	viability (Avana lentiGuide)	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	-9.75850756314587	[]	[]	-9	hSpCas9	negative selection	3584928
34794700	34794723	15	+	26780180	A375	viability (Avana lentiGuide)	CGATGGACGGGAAGACAGCGCGG	ACTC1	ENSG00000159251	2.35729004194935	[]	[]	2	hSpCas9	negative selection	3584929
34794764	34794787	15	+	26780180	A375	viability (Avana lentiGuide)	GCCGTTGTCGCACACCAGGGCGG	ACTC1	ENSG00000159251	2.24419937513232	[]	[]	2	hSpCas9	negative selection	3584930
34794761	34794784	15	+	26780180	A375	viability (Avana lentiGuide)	AGAGCCGTTGTCGCACACCAGGG	ACTC1	ENSG00000159251	4.86350534709207	[]	[]	4	hSpCas9	negative selection	3584931
34793389	34793412	15	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGTGCTCCTCGGGAGCCACACGG	ACTC1	ENSG00000159251	0.31309660793669025	[4]	[6,5]	8	hSpCas9	positive selection	3693585
34793348	34793371	15	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTTGGCCTTGGGGTTCAGCGGGG	ACTC1	ENSG00000159251	0.05872073312618106	[4]	[4,4]	1	hSpCas9	positive selection	3693586
34793249	34793272	15	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.21717135431733608	[3]	[5,3]	6	hSpCas9	positive selection	3693587
34794700	34794723	15	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CGATGGACGGGAAGACAGCGCGG	ACTC1	ENSG00000159251	0.21976062152051	[4]	[4,4]	6	hSpCas9	positive selection	3693588
34794764	34794787	15	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCCGTTGTCGCACACCAGGGCGG	ACTC1	ENSG00000159251	0.08931665934506705	[3]	[4,3]	2	hSpCas9	positive selection	3693589
34794761	34794784	15	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGAGCCGTTGTCGCACACCAGGG	ACTC1	ENSG00000159251	-0.11265557024268671	[5]	[5,4]	-2	hSpCas9	positive selection	3693590
34793389	34793412	15	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGTGCTCCTCGGGAGCCACACGG	ACTC1	ENSG00000159251	0.15108783525879046	[5]	[4,5]	3	hSpCas9	positive selection	3802192
34793348	34793371	15	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTTGGCCTTGGGGTTCAGCGGGG	ACTC1	ENSG00000159251	-0.9097891543879206	[5]	[2,1]	-8	hSpCas9	positive selection	3802193
34793249	34793272	15	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.024294576389439465	[4]	[4,3]	0	hSpCas9	positive selection	3802194
34794700	34794723	15	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CGATGGACGGGAAGACAGCGCGG	ACTC1	ENSG00000159251	-0.3080975891067235	[4]	[2,2]	-4	hSpCas9	positive selection	3802195
34794764	34794787	15	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCCGTTGTCGCACACCAGGGCGG	ACTC1	ENSG00000159251	0.14805859330093485	[4]	[3,4]	3	hSpCas9	positive selection	3802196
34794761	34794784	15	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGAGCCGTTGTCGCACACCAGGG	ACTC1	ENSG00000159251	-0.013112145852603896	[6]	[5,4]	0	hSpCas9	positive selection	3802197
34792079	34792102	15	+	26780180	A375	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	1.0773607173541	[]	[]	5	hSpCas9	negative selection	3910802
34793256	34793279	15	-	26780180	A375	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	1.32401321531566	[]	[]	7	hSpCas9	negative selection	3910803
34791224	34791247	15	-	26780180	A375	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	1.43112560405387	[]	[]	8	hSpCas9	negative selection	3910804
34792558	34792581	15	-	26780180	A375	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.708911048174601	[]	[]	2	hSpCas9	negative selection	3910805
34791157	34791180	15	+	26780180	A375	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	0.98850083298644	[]	[]	4	hSpCas9	negative selection	3910806
34793248	34793271	15	+	26780180	A375	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.951482040559416	[]	[]	4	hSpCas9	negative selection	3910807
34792079	34792102	15	+	26780180	HT29	viability (GeCKOv2 library)	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	1.54109930283255	[]	[]	7	hSpCas9	negative selection	4018768
34793256	34793279	15	-	26780180	HT29	viability (GeCKOv2 library)	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	1.12932216999434	[]	[]	5	hSpCas9	negative selection	4018769
34791224	34791247	15	-	26780180	HT29	viability (GeCKOv2 library)	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.545813170648749	[]	[]	1	hSpCas9	negative selection	4018770
34792558	34792581	15	-	26780180	HT29	viability (GeCKOv2 library)	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	1.04646250548413	[]	[]	5	hSpCas9	negative selection	4018771
34791157	34791180	15	+	26780180	HT29	viability (GeCKOv2 library)	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	1.44054105325226	[]	[]	7	hSpCas9	negative selection	4018772
34793248	34793271	15	+	26780180	HT29	viability (GeCKOv2 library)	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	1.77013536891154	[]	[]	8	hSpCas9	negative selection	4018773
34792135	34792158	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CATTGCCAATAGTGATGACTTGG	ACTC1	ENSG00000159251	0.06317553335897363	[4]	[2,3]	1	hSpCas9	positive selection	4187604
34792079	34792102	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.06520439212637791	[3]	[1,2]	-1	hSpCas9	positive selection	4187615
34793557	34793580	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	-0.6759417258830083	[3]	[0,0]	-9	hSpCas9	positive selection	4187626
34793248	34793271	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.36462327490325513	[3]	[4,1]	8	hSpCas9	positive selection	4187636
34792135	34792158	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CATTGCCAATAGTGATGACTTGG	ACTC1	ENSG00000159251	0.3538643772748299	[4]	[4,2,3,0]	2	hSpCas9	positive selection	4251626
34792079	34792102	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.06437771925239849	[2]	[0,2,1,0]	-1	hSpCas9	positive selection	4251637
34793557	34793580	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	0.3216454446375976	[1]	[0,3,0,0]	2	hSpCas9	positive selection	4251648
34793248	34793271	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.8871488062007581	[3]	[1,0,0,4]	6	hSpCas9	positive selection	4251658
34792558	34792581	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	-0.09344815065572123	[3]	[2,1]	-2	hSpCas9	positive selection	4254311
34791157	34791180	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.08266943264429655	[4]	[3,2]	-2	hSpCas9	positive selection	4254312
34793248	34793271	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	-0.7915237317092736	[2]	[0,0]	-9	hSpCas9	positive selection	4254313
34791224	34791247	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.4723875398769232	[2]	[3,3]	8	hSpCas9	positive selection	4318594
34792079	34792102	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.5159929150906033	[2]	[1,0]	-8	hSpCas9	positive selection	4318595
34793256	34793279	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	0.3732848817051987	[4]	[4,3]	7	hSpCas9	positive selection	4318596
34792508	34792530	15	+	27760321	OCIAML3	viability	AGCGTAGCCCTCATAGATGGGG	ACTC1	ENSG00000159251	0.2096564365686268	[364,273]	[154,457]	2	hSpCas9	negative selection	4375856
34793463	34793485	15	+	27760321	OCIAML3	viability	GTGATGATACCATGCTCGATGG	ACTC1	ENSG00000159251	-0.13770087537991715	[444,370]	[267,315]	-1	hSpCas9	negative selection	4375857
34793517	34793539	15	+	27760321	OCIAML3	viability	TGGGCTTCATCACCTACGTAGG	ACTC1	ENSG00000159251	-0.2736217242703221	[501,410]	[200,414]	-3	hSpCas9	negative selection	4375858
34793557	34793579	15	-	27760321	OCIAML3	viability	TTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	0.7579315654001975	[143,123]	[108,264]	8	hSpCas9	negative selection	4375859
34794674	34794696	15	+	27760321	OCIAML3	viability	GTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	-0.03189086604796998	[826,881]	[568,772]	0	hSpCas9	negative selection	4375860
34792508	34792530	15	+	27760321	OCIAML2	viability	AGCGTAGCCCTCATAGATGGGG	ACTC1	ENSG00000159251	-1.2555358660882021	[364,273]	[77,145]	-8	hSpCas9	negative selection	4459319
34793463	34793485	15	+	27760321	OCIAML2	viability	GTGATGATACCATGCTCGATGG	ACTC1	ENSG00000159251	0.1105622589662609	[444,370]	[353,355]	1	hSpCas9	negative selection	4459320
34793517	34793539	15	+	27760321	OCIAML2	viability	TGGGCTTCATCACCTACGTAGG	ACTC1	ENSG00000159251	0.4004805603810576	[501,410]	[434,550]	5	hSpCas9	negative selection	4459321
34793557	34793579	15	-	27760321	OCIAML2	viability	TTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	0.2084577665744174	[143,123]	[139,104]	2	hSpCas9	negative selection	4459322
34794674	34794696	15	+	27760321	OCIAML2	viability	GTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.5016323654936646	[826,881]	[974,996]	7	hSpCas9	negative selection	4459323
34792508	34792530	15	+	27760321	MV411	viability	AGCGTAGCCCTCATAGATGGGG	ACTC1	ENSG00000159251	-0.42172282279049317	[364,273]	[245,20]	-3	hSpCas9	negative selection	4542782
34793463	34793485	15	+	27760321	MV411	viability	GTGATGATACCATGCTCGATGG	ACTC1	ENSG00000159251	1.1794822948173962	[444,370]	[701,464]	8	hSpCas9	negative selection	4542783
34793517	34793539	15	+	27760321	MV411	viability	TGGGCTTCATCACCTACGTAGG	ACTC1	ENSG00000159251	-1.0037795757130554	[501,410]	[19,343]	-6	hSpCas9	negative selection	4542784
34793557	34793579	15	-	27760321	MV411	viability	TTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	-1.3497291690016173	[143,123]	[30,39]	-7	hSpCas9	negative selection	4542785
34794674	34794696	15	+	27760321	MV411	viability	GTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.7379902689626806	[826,881]	[523,1579]	5	hSpCas9	negative selection	4542786
34792508	34792530	15	+	27760321	HL60	viability	AGCGTAGCCCTCATAGATGGGG	ACTC1	ENSG00000159251	-0.3376486557851592	[364,273]	[197,211]	-4	hSpCas9	negative selection	4626245
34793463	34793485	15	+	27760321	HL60	viability	GTGATGATACCATGCTCGATGG	ACTC1	ENSG00000159251	0.2623404839104474	[444,370]	[284,517]	3	hSpCas9	negative selection	4626246
34793517	34793539	15	+	27760321	HL60	viability	TGGGCTTCATCACCTACGTAGG	ACTC1	ENSG00000159251	0.20330430502791627	[501,410]	[434,418]	2	hSpCas9	negative selection	4626247
34793557	34793579	15	-	27760321	HL60	viability	TTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	-0.2889582091832359	[143,123]	[83,94]	-3	hSpCas9	negative selection	4626248
34794674	34794696	15	+	27760321	HL60	viability	GTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.14993586117296165	[826,881]	[780,776]	1	hSpCas9	negative selection	4626249
34792508	34792530	15	+	27760321	HT1080	viability	AGCGTAGCCCTCATAGATGGGG	ACTC1	ENSG00000159251	-0.18134444991137966	[273,213]	[100,68]	-1	hSpCas9	negative selection	4709708
34793463	34793485	15	+	27760321	HT1080	viability	GTGATGATACCATGCTCGATGG	ACTC1	ENSG00000159251	0.6996290965614617	[370,289]	[294,124]	4	hSpCas9	negative selection	4709709
34793517	34793539	15	+	27760321	HT1080	viability	TGGGCTTCATCACCTACGTAGG	ACTC1	ENSG00000159251	1.384182463101188	[410,320]	[329,435]	7	hSpCas9	negative selection	4709710
34793557	34793579	15	-	27760321	HT1080	viability	TTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	-0.03929607975537164	[123,96]	[28,57]	0	hSpCas9	negative selection	4709711
34794674	34794696	15	+	27760321	HT1080	viability	GTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.6684383389411144	[881,687]	[317,692]	3	hSpCas9	negative selection	4709712
34792508	34792530	15	+	27760321	HT29	viability after 7 days	AGCGTAGCCCTCATAGATGGGG	ACTC1	ENSG00000159251	-0.13331410011268752	[273,213]	[273,391,192]	-2	hSpCas9	negative selection	4793171
34793463	34793485	15	+	27760321	HT29	viability after 7 days	GTGATGATACCATGCTCGATGG	ACTC1	ENSG00000159251	-0.05213703072939274	[370,289]	[470,522,248]	0	hSpCas9	negative selection	4793172
34793517	34793539	15	+	27760321	HT29	viability after 7 days	TGGGCTTCATCACCTACGTAGG	ACTC1	ENSG00000159251	0.0597527770006352	[410,320]	[614,461,413]	0	hSpCas9	negative selection	4793173
34793557	34793579	15	-	27760321	HT29	viability after 7 days	TTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	0.09051597133028322	[123,96]	[108,230,108]	1	hSpCas9	negative selection	4793174
34794674	34794696	15	+	27760321	HT29	viability after 7 days	GTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	-0.22053581688353996	[881,687]	[693,797,1073]	-3	hSpCas9	negative selection	4793175
34792508	34792530	15	+	27760321	HT29	viability after 25 days	AGCGTAGCCCTCATAGATGGGG	ACTC1	ENSG00000159251	0.03601213756766797	[273,213]	[344,218,289]	0	hSpCas9	negative selection	4876634
34793463	34793485	15	+	27760321	HT29	viability after 25 days	GTGATGATACCATGCTCGATGG	ACTC1	ENSG00000159251	0.07713868589900261	[370,289]	[274,525,401]	0	hSpCas9	negative selection	4876635
34793517	34793539	15	+	27760321	HT29	viability after 25 days	TGGGCTTCATCACCTACGTAGG	ACTC1	ENSG00000159251	0.6502302241280955	[410,320]	[771,421,779]	7	hSpCas9	negative selection	4876636
34793557	34793579	15	-	27760321	HT29	viability after 25 days	TTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	0.22366573603905748	[123,96]	[64,91,306]	2	hSpCas9	negative selection	4876637
34794674	34794696	15	+	27760321	HT29	viability after 25 days	GTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.24855544481362712	[881,687]	[906,979,1347]	2	hSpCas9	negative selection	4876638
34792508	34792530	15	+	27760321	HT29	viability after 22 days	AGCGTAGCCCTCATAGATGGGG	ACTC1	ENSG00000159251	0.44648470861371237	[273,213]	[334,386,432]	5	hSpCas9	negative selection	4960097
34793463	34793485	15	+	27760321	HT29	viability after 22 days	GTGATGATACCATGCTCGATGG	ACTC1	ENSG00000159251	0.3541410220395278	[370,289]	[546,497,417]	4	hSpCas9	negative selection	4960098
34793517	34793539	15	+	27760321	HT29	viability after 22 days	TGGGCTTCATCACCTACGTAGG	ACTC1	ENSG00000159251	0.7001957606102014	[410,320]	[547,638,880]	7	hSpCas9	negative selection	4960099
34793557	34793579	15	-	27760321	HT29	viability after 22 days	TTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	0.18228727835864134	[123,96]	[94,117,223]	1	hSpCas9	negative selection	4960100
34794674	34794696	15	+	27760321	HT29	viability after 22 days	GTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.12239402567231772	[881,687]	[1124,919,913]	1	hSpCas9	negative selection	4960101
34792508	34792530	15	+	27760321	HT29	viability after 19 days	AGCGTAGCCCTCATAGATGGGG	ACTC1	ENSG00000159251	0.6204111112043981	[273,213]	[355,490,431]	6	hSpCas9	negative selection	5043560
34793463	34793485	15	+	27760321	HT29	viability after 19 days	GTGATGATACCATGCTCGATGG	ACTC1	ENSG00000159251	0.5952248932834017	[370,289]	[729,602,402]	6	hSpCas9	negative selection	5043561
34793517	34793539	15	+	27760321	HT29	viability after 19 days	TGGGCTTCATCACCTACGTAGG	ACTC1	ENSG00000159251	0.8506003586057784	[410,320]	[984,678,628]	8	hSpCas9	negative selection	5043562
34793557	34793579	15	-	27760321	HT29	viability after 19 days	TTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	0.3116798974136403	[123,96]	[101,77,279]	3	hSpCas9	negative selection	5043563
34794674	34794696	15	+	27760321	HT29	viability after 19 days	GTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.2266782179229878	[881,687]	[1122,840,1188]	2	hSpCas9	negative selection	5043564
34792508	34792530	15	+	27760321	HT29	viability after 16 days	AGCGTAGCCCTCATAGATGGGG	ACTC1	ENSG00000159251	0.6501655534735253	[273,213]	[583,348,368]	7	hSpCas9	negative selection	5127023
34793463	34793485	15	+	27760321	HT29	viability after 16 days	GTGATGATACCATGCTCGATGG	ACTC1	ENSG00000159251	0.4423507981692349	[370,289]	[373,358,765]	5	hSpCas9	negative selection	5127024
34793517	34793539	15	+	27760321	HT29	viability after 16 days	TGGGCTTCATCACCTACGTAGG	ACTC1	ENSG00000159251	0.19738216832016411	[410,320]	[559,472,383]	2	hSpCas9	negative selection	5127025
34793557	34793579	15	-	27760321	HT29	viability after 16 days	TTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	0.12738749377975345	[123,96]	[108,199,91]	1	hSpCas9	negative selection	5127026
34794674	34794696	15	+	27760321	HT29	viability after 16 days	GTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.04165013822564556	[881,687]	[999,742,981]	0	hSpCas9	negative selection	5127027
34792508	34792530	15	+	27760321	HT29	viability after 13 days	AGCGTAGCCCTCATAGATGGGG	ACTC1	ENSG00000159251	-0.3946315507087079	[273,213]	[234,162,245]	-4	hSpCas9	negative selection	5210486
34793463	34793485	15	+	27760321	HT29	viability after 13 days	GTGATGATACCATGCTCGATGG	ACTC1	ENSG00000159251	0.2753000095030502	[370,289]	[649,299,442]	3	hSpCas9	negative selection	5210487
34793517	34793539	15	+	27760321	HT29	viability after 13 days	TGGGCTTCATCACCTACGTAGG	ACTC1	ENSG00000159251	0.2828748298101054	[410,320]	[462,436,641]	3	hSpCas9	negative selection	5210488
34793557	34793579	15	-	27760321	HT29	viability after 13 days	TTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	0.06456781216831065	[123,96]	[98,61,234]	0	hSpCas9	negative selection	5210489
34794674	34794696	15	+	27760321	HT29	viability after 13 days	GTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	-0.13355774737037607	[881,687]	[710,735,1030]	-2	hSpCas9	negative selection	5210490
34792508	34792530	15	+	27760321	HT29	viability after 10 days	AGCGTAGCCCTCATAGATGGGG	ACTC1	ENSG00000159251	-0.12417314950820058	[273,213]	[342,279,216]	-2	hSpCas9	negative selection	5293949
34793463	34793485	15	+	27760321	HT29	viability after 10 days	GTGATGATACCATGCTCGATGG	ACTC1	ENSG00000159251	0.25665918475570976	[370,289]	[542,529,408]	3	hSpCas9	negative selection	5293950
34793517	34793539	15	+	27760321	HT29	viability after 10 days	TGGGCTTCATCACCTACGTAGG	ACTC1	ENSG00000159251	0.255231078382051	[410,320]	[541,602,493]	3	hSpCas9	negative selection	5293951
34793557	34793579	15	-	27760321	HT29	viability after 10 days	TTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	0.7518779324069608	[123,96]	[210,320,168]	8	hSpCas9	negative selection	5293952
34794674	34794696	15	+	27760321	HT29	viability after 10 days	GTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	-0.1502566137691247	[881,687]	[864,624,1145]	-2	hSpCas9	negative selection	5293953
34792508	34792530	15	+	27760321	MOLM13	viability	AGCGTAGCCCTCATAGATGGGG	ACTC1	ENSG00000159251	-2.426867906416669	[364,273]	[29,35]	-8	hSpCas9	negative selection	5377412
34793463	34793485	15	+	27760321	MOLM13	viability	GTGATGATACCATGCTCGATGG	ACTC1	ENSG00000159251	0.8433054221336	[444,370]	[541,299]	6	hSpCas9	negative selection	5377413
34793517	34793539	15	+	27760321	MOLM13	viability	TGGGCTTCATCACCTACGTAGG	ACTC1	ENSG00000159251	0.34714682460375557	[501,410]	[271,371]	2	hSpCas9	negative selection	5377414
34793557	34793579	15	-	27760321	MOLM13	viability	TTCTCATAGGGAGTTATGGTGG	ACTC1	ENSG00000159251	2.108315279765984	[143,123]	[256,382]	9	hSpCas9	negative selection	5377415
34794674	34794696	15	+	27760321	MOLM13	viability	GTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.7832791203982737	[826,881]	[1047,652]	5	hSpCas9	negative selection	5377416
34795463	34795486	15	+	27661255	K562	viability	GACCAGGCGAGGAGTGAACGCGG	ACTC1	ENSG00000159251	0.22859261741763026	[1151,1226]	[1239,1002]	7	dCas9-KRAB	negative selection	5460716
34795489	34795512	15	+	27661255	K562	viability	GCCGGGCGCTGACTCACCGTCGG	ACTC1	ENSG00000159251	0.5304147275398343	[621,854]	[918,785]	9	dCas9-KRAB	negative selection	5460717
34795492	34795515	15	+	27661255	K562	viability	GGGCGCTGACTCACCGTCGGCGG	ACTC1	ENSG00000159251	-0.052827373930013244	[1303,1204]	[1008,931]	-2	dCas9-KRAB	negative selection	5460718
34795279	34795302	15	-	27661255	K562	viability	GTCCTCGCAGGACCTCGCAGGGG	ACTC1	ENSG00000159251	0.2927772777829948	[650,651]	[684,596]	8	dCas9-KRAB	negative selection	5460719
34795505	34795528	15	-	27661255	K562	viability	GAGCCGACCCGCCCCGCCGACGG	ACTC1	ENSG00000159251	0.08968386060979494	[849,1198]	[905,830]	3	dCas9-KRAB	negative selection	5460720
34792558	34792581	15	-	27260156	BXPC3	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.17311362790385434	[484]	[594,491,545,662]	4	hSpCas9	negative selection	5526771
34791157	34791180	15	+	27260156	BXPC3	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	0.04377137457309144	[1127]	[1192,1017,1286,1393]	1	hSpCas9	negative selection	5526772
34793248	34793271	15	+	27260156	BXPC3	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.17937700873995951	[364]	[343,464,388,548]	4	hSpCas9	negative selection	5526773
34791224	34791247	15	-	27260156	BXPC3	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.12515482326770788	[421]	[402,491,288,426]	-3	hSpCas9	negative selection	5591054
34792079	34792102	15	+	27260156	BXPC3	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.022596183598792785	[306]	[271,338,245,465]	0	hSpCas9	negative selection	5591055
34793256	34793279	15	-	27260156	BXPC3	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.17785347088682568	[1024]	[836,914,874,1199]	-4	hSpCas9	negative selection	5591056
34792558	34792581	15	-	27260156	A673	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.39635800772686747	[484]	[763,710,794,796]	8	hSpCas9	negative selection	5648022
34791157	34791180	15	+	27260156	A673	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.3203982033104045	[1127]	[1120,1041,1061,1118]	-7	hSpCas9	negative selection	5648023
34793248	34793271	15	+	27260156	A673	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.1352080175002117	[364]	[456,458,534,469]	3	hSpCas9	negative selection	5648024
34791224	34791247	15	-	27260156	A673	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.0792989691538667	[421]	[559,431,371,569]	-2	hSpCas9	negative selection	5712305
34792079	34792102	15	+	27260156	A673	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.04178540384309681	[306]	[364,390,380,377]	1	hSpCas9	negative selection	5712306
34793256	34793279	15	-	27260156	A673	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.287497934495334	[1024]	[1149,1045,848,1002]	-6	hSpCas9	negative selection	5712307
34792558	34792581	15	-	27260156	A375	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.3794759407636701	[484]	[878,804,688,598]	5	hSpCas9	negative selection	5769273
34791157	34791180	15	+	27260156	A375	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.293051665822465	[1127]	[896,1228,1188,1009]	-4	hSpCas9	negative selection	5769274
34793248	34793271	15	+	27260156	A375	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.16638791050896343	[364]	[380,560,634,359]	2	hSpCas9	negative selection	5769275
34791224	34791247	15	-	27260156	A375	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.17381813987414096	[421]	[553,355,400,425]	-3	hSpCas9	negative selection	5833556
34792079	34792102	15	+	27260156	A375	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.19955410043287447	[306]	[269,421,380,202]	-3	hSpCas9	negative selection	5833557
34793256	34793279	15	-	27260156	A375	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	0.02337580954107321	[1024]	[1276,1246,1385,984]	0	hSpCas9	negative selection	5833558
34792558	34792581	15	-	27260156	COLO741	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.45698173359811034	[484]	[842,864,841]	8	hSpCas9	negative selection	5890524
34791157	34791180	15	+	27260156	COLO741	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.2678065976475288	[1127]	[1305,1044,1242]	-5	hSpCas9	negative selection	5890525
34793248	34793271	15	+	27260156	COLO741	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.11967665218208642	[364]	[659,369,501]	2	hSpCas9	negative selection	5890526
34791224	34791247	15	-	27260156	COLO741	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.28644032554250975	[421]	[691,295,363]	-6	hSpCas9	negative selection	5954807
34792079	34792102	15	+	27260156	COLO741	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.12988777759990477	[306]	[335,436,303]	-3	hSpCas9	negative selection	5954808
34793256	34793279	15	-	27260156	COLO741	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.04105881977989356	[1024]	[1281,1322,1215]	-1	hSpCas9	negative selection	5954809
34792558	34792581	15	-	27260156	CAL120	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.6973421660745605	[484]	[885,746,1282]	8	hSpCas9	negative selection	6011775
34791157	34791180	15	+	27260156	CAL120	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.5401241777652891	[1127]	[1138,722,1057]	-6	hSpCas9	negative selection	6011776
34793248	34793271	15	+	27260156	CAL120	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.46847965762039784	[364]	[843,470,602]	7	hSpCas9	negative selection	6011777
34791224	34791247	15	-	27260156	CAL120	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.6942580784144456	[421]	[302,439,228]	-7	hSpCas9	negative selection	6076058
34792079	34792102	15	+	27260156	CAL120	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.48432084167481815	[306]	[173,343,285]	-6	hSpCas9	negative selection	6076059
34793256	34793279	15	-	27260156	CAL120	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	0.17251453500726543	[1024]	[2271,979,1189]	2	hSpCas9	negative selection	6076060
34792558	34792581	15	-	27260156	CADOES1	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.4565820377847153	[484]	[764,423,698,585]	7	hSpCas9	negative selection	6133026
34791157	34791180	15	+	27260156	CADOES1	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.28736259853040746	[1127]	[839,777,919,901]	-5	hSpCas9	negative selection	6133027
34793248	34793271	15	+	27260156	CADOES1	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.13740834173525887	[364]	[515,347,285,341]	2	hSpCas9	negative selection	6133028
34791224	34791247	15	-	27260156	CADOES1	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.33995645110632566	[421]	[283,213,436,304]	-5	hSpCas9	negative selection	6197309
34792079	34792102	15	+	27260156	CADOES1	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.12661259761533505	[306]	[273,238,263,475]	2	hSpCas9	negative selection	6197310
34793256	34793279	15	-	27260156	CADOES1	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.03751571501653794	[1024]	[805,889,900,1125]	0	hSpCas9	negative selection	6197311
34792558	34792581	15	-	27260156	EWS502	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.49968718184586336	[484]	[808,703,802,566]	8	hSpCas9	negative selection	6254277
34791157	34791180	15	+	27260156	EWS502	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.38602854374237083	[1127]	[1025,873,863,873]	-6	hSpCas9	negative selection	6254278
34793248	34793271	15	+	27260156	EWS502	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.02307877052206614	[364]	[284,409,537,347]	0	hSpCas9	negative selection	6254279
34791224	34791247	15	-	27260156	EWS502	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.3291784642858642	[421]	[312,368,354,391]	-5	hSpCas9	negative selection	6318560
34792079	34792102	15	+	27260156	EWS502	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.09283744469683508	[306]	[236,369,313,302]	-2	hSpCas9	negative selection	6318561
34793256	34793279	15	-	27260156	EWS502	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.12362353957552696	[1024]	[1042,698,1031,1231]	-2	hSpCas9	negative selection	6318562
34792558	34792581	15	-	27260156	EW8	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.39767688094704556	[484]	[559,506,573,423]	7	hSpCas9	negative selection	6375528
34791157	34791180	15	+	27260156	EW8	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.3782926920810571	[1127]	[672,582,563,1009]	-6	hSpCas9	negative selection	6375529
34793248	34793271	15	+	27260156	EW8	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.2592936014411452	[364]	[358,370,262,437]	5	hSpCas9	negative selection	6375530
34791224	34791247	15	-	27260156	EW8	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.2016699843519717	[421]	[334,280,223,364]	-4	hSpCas9	negative selection	6439811
34792079	34792102	15	+	27260156	EW8	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.44852236382349364	[306]	[201,180,109,249]	-7	hSpCas9	negative selection	6439812
34793256	34793279	15	-	27260156	EW8	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.08663607175967236	[1024]	[840,855,685,766]	-2	hSpCas9	negative selection	6439813
34792558	34792581	15	-	27260156	CORL105	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.3096044351055721	[484]	[667,735,680,723]	6	hSpCas9	negative selection	6496779
34791157	34791180	15	+	27260156	CORL105	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.0635568336955763	[1127]	[1320,1242,1253,1236]	-1	hSpCas9	negative selection	6496780
34793248	34793271	15	+	27260156	CORL105	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.3458087781795339	[364]	[490,544,730,432]	6	hSpCas9	negative selection	6496781
34791224	34791247	15	-	27260156	CORL105	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.10436654676360778	[421]	[751,425,447,494]	2	hSpCas9	negative selection	6561062
34792079	34792102	15	+	27260156	CORL105	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.03541509392645903	[306]	[431,245,464,349]	0	hSpCas9	negative selection	6561063
34793256	34793279	15	-	27260156	CORL105	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.17738120506397592	[1024]	[1106,893,1101,1151]	-3	hSpCas9	negative selection	6561064
34792558	34792581	15	-	27260156	HS294T	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.5889098975283932	[484]	[214,271,415,220]	7	hSpCas9	negative selection	6618030
34791157	34791180	15	+	27260156	HS294T	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.10359184998774462	[1127]	[355,353,457,471]	-1	hSpCas9	negative selection	6618031
34793248	34793271	15	+	27260156	HS294T	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.8520653266364864	[364]	[409,211,174,197]	9	hSpCas9	negative selection	6618032
34791224	34791247	15	-	27260156	HS294T	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.855132087270962	[421]	[97,71,86,105]	-8	hSpCas9	negative selection	6682313
34792079	34792102	15	+	27260156	HS294T	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.06771500608474379	[306]	[69,146,148,137]	0	hSpCas9	negative selection	6682314
34793256	34793279	15	-	27260156	HS294T	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.21038421117682982	[1024]	[270,266,265,620]	-3	hSpCas9	negative selection	6682315
34792558	34792581	15	-	27260156	HCC44	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.28086398225740095	[484]	[574,535,996,620]	4	hSpCas9	negative selection	6739281
34791157	34791180	15	+	27260156	HCC44	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.5184398057141717	[1127]	[705,818,1463,665]	-7	hSpCas9	negative selection	6739282
34793248	34793271	15	+	27260156	HCC44	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	-0.1972352376571299	[364]	[404,285,386,377]	-3	hSpCas9	negative selection	6739283
34791224	34791247	15	-	27260156	HCC44	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.36199297686632625	[421]	[339,258,533,389]	-5	hSpCas9	negative selection	6803564
34792079	34792102	15	+	27260156	HCC44	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.5901406171157739	[306]	[249,143,404,167]	-7	hSpCas9	negative selection	6803565
34793256	34793279	15	-	27260156	HCC44	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.36700847487115573	[1024]	[978,632,1128,930]	-5	hSpCas9	negative selection	6803566
34792558	34792581	15	-	27260156	G402	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.6998817157705236	[484]	[1030,596,724,1452]	8	hSpCas9	negative selection	6860532
34791157	34791180	15	+	27260156	G402	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.22677998798822419	[1127]	[1011,1372,1404,910]	-3	hSpCas9	negative selection	6860533
34793248	34793271	15	+	27260156	G402	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.8624777497395419	[364]	[670,1243,683,649]	9	hSpCas9	negative selection	6860534
34791224	34791247	15	-	27260156	G402	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.26998734673008085	[421]	[210,846,774,602]	3	hSpCas9	negative selection	6924815
34792079	34792102	15	+	27260156	G402	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.146519744402074	[306]	[707,239,576,175]	1	hSpCas9	negative selection	6924816
34793256	34793279	15	-	27260156	G402	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	0.6843004077749781	[1024]	[2938,1779,1991,1467]	8	hSpCas9	negative selection	6924817
34792558	34792581	15	-	27260156	L33	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.5657971457462253	[484]	[572,355,439,732]	9	hSpCas9	negative selection	6981783
34791157	34791180	15	+	27260156	L33	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.04776445650335903	[1127]	[1080,476,564,1218]	-1	hSpCas9	negative selection	6981784
34793248	34793271	15	+	27260156	L33	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.3929473479725083	[364]	[451,220,238,544]	7	hSpCas9	negative selection	6981785
34791224	34791247	15	-	27260156	L33	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.32275924847922643	[421]	[383,119,208,338]	-6	hSpCas9	negative selection	7046066
34792079	34792102	15	+	27260156	L33	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.38199951263774323	[306]	[252,97,146,215]	-7	hSpCas9	negative selection	7046067
34793256	34793279	15	-	27260156	L33	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.1682124182871404	[1024]	[1052,321,533,955]	-4	hSpCas9	negative selection	7046068
34792558	34792581	15	-	27260156	K562	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.5885863063849357	[484]	[581,391,932,658]	7	hSpCas9	negative selection	7103034
34791157	34791180	15	+	27260156	K562	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.09708359434033031	[1127]	[888,1125,967,780]	-1	hSpCas9	negative selection	7103035
34793248	34793271	15	+	27260156	K562	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.007012944082279704	[364]	[281,300,304,398]	0	hSpCas9	negative selection	7103036
34791224	34791247	15	-	27260156	K562	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.1277330680377901	[421]	[472,381,341,201]	-2	hSpCas9	negative selection	7167317
34792079	34792102	15	+	27260156	K562	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.10106529991783975	[306]	[407,250,204,172]	-1	hSpCas9	negative selection	7167318
34793256	34793279	15	-	27260156	K562	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	0.12315272934061783	[1024]	[1195,791,968,1005]	1	hSpCas9	negative selection	7167319
34792558	34792581	15	-	27260156	HT29	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.2931729460896513	[484]	[838,671,744,642]	6	hSpCas9	negative selection	7224285
34791157	34791180	15	+	27260156	HT29	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.31246876547119995	[1127]	[1164,1137,988,1121]	-6	hSpCas9	negative selection	7224286
34793248	34793271	15	+	27260156	HT29	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.1914227721080424	[364]	[567,529,517,423]	4	hSpCas9	negative selection	7224287
34791224	34791247	15	-	27260156	HT29	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.12883664816938717	[421]	[574,430,464,413]	-3	hSpCas9	negative selection	7288568
34792079	34792102	15	+	27260156	HT29	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.14628924629232232	[306]	[483,328,305,248]	-3	hSpCas9	negative selection	7288569
34793256	34793279	15	-	27260156	HT29	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.19902091628603846	[1024]	[1079,1204,1011,1050]	-4	hSpCas9	negative selection	7288570
34792558	34792581	15	-	27260156	MHHES1	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.43157976336397263	[484]	[841,685,743,678]	7	hSpCas9	negative selection	7345536
34791157	34791180	15	+	27260156	MHHES1	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.32604149673033156	[1127]	[930,888,1232,966]	-6	hSpCas9	negative selection	7345537
34793248	34793271	15	+	27260156	MHHES1	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.19868712646739714	[364]	[563,306,563,442]	3	hSpCas9	negative selection	7345538
34791224	34791247	15	-	27260156	MHHES1	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.08717450786716371	[421]	[521,491,436,361]	-2	hSpCas9	negative selection	7409819
34792079	34792102	15	+	27260156	MHHES1	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.2861205945521753	[306]	[338,398,244,185]	-5	hSpCas9	negative selection	7409820
34793256	34793279	15	-	27260156	MHHES1	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.11167941665279768	[1024]	[1262,922,1229,885]	-2	hSpCas9	negative selection	7409821
34792558	34792581	15	-	27260156	MEWO	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.17051959367286404	[484]	[493,445,588]	4	hSpCas9	negative selection	7466787
34791157	34791180	15	+	27260156	MEWO	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.38600228666251923	[1127]	[954,829,665]	-7	hSpCas9	negative selection	7466788
34793248	34793271	15	+	27260156	MEWO	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	-0.16881570060177498	[364]	[343,311,262]	-4	hSpCas9	negative selection	7466789
34791224	34791247	15	-	27260156	MEWO	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.41405705647653535	[421]	[352,262,283]	-7	hSpCas9	negative selection	7531070
34792079	34792102	15	+	27260156	MEWO	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.037797989116792885	[306]	[366,179,351]	0	hSpCas9	negative selection	7531071
34793256	34793279	15	-	27260156	MEWO	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.13247033138440578	[1024]	[999,775,872]	-3	hSpCas9	negative selection	7531072
34792558	34792581	15	-	27260156	LNCAPCLONEFGC	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.6158323968825719	[484]	[809,567,828,512]	8	hSpCas9	negative selection	7588038
34791157	34791180	15	+	27260156	LNCAPCLONEFGC	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.2008918278039531	[1127]	[828,754,1108,904]	-3	hSpCas9	negative selection	7588039
34793248	34793271	15	+	27260156	LNCAPCLONEFGC	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.15872430228269568	[364]	[255,409,546,288]	2	hSpCas9	negative selection	7588040
34791224	34791247	15	-	27260156	LNCAPCLONEFGC	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.163024853333442	[421]	[455,331,565,383]	2	hSpCas9	negative selection	7652321
34792079	34792102	15	+	27260156	LNCAPCLONEFGC	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.08519612679283473	[306]	[302,171,365,227]	-1	hSpCas9	negative selection	7652322
34793256	34793279	15	-	27260156	LNCAPCLONEFGC	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	0.20613801081195238	[1024]	[1051,1011,1252,997]	3	hSpCas9	negative selection	7652323
34792558	34792581	15	-	27260156	PANC0327	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.1948171051345312	[484]	[419,414,784,356]	3	hSpCas9	negative selection	7709289
34791157	34791180	15	+	27260156	PANC0327	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	0.15058610932175154	[1127]	[1030,1102,1047,1260]	2	hSpCas9	negative selection	7709290
34793248	34793271	15	+	27260156	PANC0327	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.004013213095338475	[364]	[384,196,394,344]	0	hSpCas9	negative selection	7709291
34791224	34791247	15	-	27260156	PANC0327	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.43250422085649554	[421]	[120,223,306,452]	-6	hSpCas9	negative selection	7773572
34792079	34792102	15	+	27260156	PANC0327	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.24976411972528312	[306]	[392,142,242,162]	-4	hSpCas9	negative selection	7773573
34793256	34793279	15	-	27260156	PANC0327	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	0.07846283907867124	[1024]	[848,1116,926,922]	1	hSpCas9	negative selection	7773574
34792558	34792581	15	-	27260156	NCIH2009	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.6853203324074002	[484]	[1219,1137,933]	8	hSpCas9	negative selection	7830540
34791157	34791180	15	+	27260156	NCIH2009	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.10332004786814619	[1127]	[1675,1192,1575]	-1	hSpCas9	negative selection	7830541
34793248	34793271	15	+	27260156	NCIH2009	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.30301824162608615	[364]	[781,551,583]	4	hSpCas9	negative selection	7830542
34791224	34791247	15	-	27260156	NCIH2009	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.09213674475248623	[421]	[648,518,509]	-1	hSpCas9	negative selection	7894823
34792079	34792102	15	+	27260156	NCIH2009	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.14807950015175986	[306]	[332,326,490]	-2	hSpCas9	negative selection	7894824
34793256	34793279	15	-	27260156	NCIH2009	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.1772836855213037	[1024]	[1146,1359,1264]	-2	hSpCas9	negative selection	7894825
34792558	34792581	15	-	27260156	NCIH1373	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.9498639166061469	[484]	[1673,741,873,272]	8	hSpCas9	negative selection	7951791
34791157	34791180	15	+	27260156	NCIH1373	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.27477584979245906	[1127]	[1124,1267,575,318]	-3	hSpCas9	negative selection	7951792
34793248	34793271	15	+	27260156	NCIH1373	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.3843590668123164	[364]	[546,302,390,248]	4	hSpCas9	negative selection	7951793
34791224	34791247	15	-	27260156	NCIH1373	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.589819095049656	[421]	[371,374,137,99]	-5	hSpCas9	negative selection	8016074
34792079	34792102	15	+	27260156	NCIH1373	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.958437777570712	[306]	[198,83,176,69]	-7	hSpCas9	negative selection	8016075
34793256	34793279	15	-	27260156	NCIH1373	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	0.14383627610125416	[1024]	[1730,983,982,392]	1	hSpCas9	negative selection	8016076
34792558	34792581	15	-	27260156	PATU8902	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.6542038342549957	[484]	[858,1195,968,1271]	7	hSpCas9	negative selection	8073042
34791157	34791180	15	+	27260156	PATU8902	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	0.20066983838481045	[1127]	[2095,1323,1890,1876]	2	hSpCas9	negative selection	8073043
34793248	34793271	15	+	27260156	PATU8902	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.8223989242467055	[364]	[964,1543,527,614]	8	hSpCas9	negative selection	8073044
34791224	34791247	15	-	27260156	PATU8902	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.4127649198830054	[421]	[1135,775,577,667]	4	hSpCas9	negative selection	8137325
34792079	34792102	15	+	27260156	PATU8902	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.024773351785343234	[306]	[406,539,446,326]	0	hSpCas9	negative selection	8137326
34793256	34793279	15	-	27260156	PATU8902	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.31954635848705537	[1024]	[949,1471,1115,1024]	-3	hSpCas9	negative selection	8137327
34792558	34792581	15	-	27260156	PANC1	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.3408248142286583	[484]	[432,676,661,386]	5	hSpCas9	negative selection	8194293
34791157	34791180	15	+	27260156	PANC1	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	0.1682867052622785	[1127]	[880,1169,1642,728]	2	hSpCas9	negative selection	8194294
34793248	34793271	15	+	27260156	PANC1	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.6142049445511155	[364]	[410,826,353,403]	8	hSpCas9	negative selection	8194295
34791224	34791247	15	-	27260156	PANC1	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.20894881563998174	[421]	[482,462,300,426]	3	hSpCas9	negative selection	8258576
34792079	34792102	15	+	27260156	PANC1	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.2783772644173374	[306]	[215,436,338,309]	4	hSpCas9	negative selection	8258577
34793256	34793279	15	-	27260156	PANC1	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	0.2978754858861812	[1024]	[1080,1266,1019,994]	5	hSpCas9	negative selection	8258578
34792558	34792581	15	-	27260156	PANC0813	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.6434760978106617	[484]	[1009,536,949,1062]	8	hSpCas9	negative selection	8315544
34791157	34791180	15	+	27260156	PANC0813	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	0.06414367170754232	[1127]	[1706,1553,1090,1223]	1	hSpCas9	negative selection	8315545
34793248	34793271	15	+	27260156	PANC0813	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.6543751783494048	[364]	[938,530,539,709]	9	hSpCas9	negative selection	8315546
34791224	34791247	15	-	27260156	PANC0813	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.12964429292143798	[421]	[444,526,410,428]	-2	hSpCas9	negative selection	8379827
34792079	34792102	15	+	27260156	PANC0813	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.003993895184108975	[306]	[424,284,519,229]	0	hSpCas9	negative selection	8379828
34793256	34793279	15	-	27260156	PANC0813	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.11787223035531857	[1024]	[1046,896,1206,1270]	-2	hSpCas9	negative selection	8379829
34792558	34792581	15	-	27260156	RDES	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.42219198224426135	[484]	[690,759,672,866]	6	hSpCas9	negative selection	8436795
34791157	34791180	15	+	27260156	RDES	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.36913066320282717	[1127]	[836,954,1182,1068]	-6	hSpCas9	negative selection	8436796
34793248	34793271	15	+	27260156	RDES	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.181707818932066	[364]	[403,383,490,664]	3	hSpCas9	negative selection	8436797
34791224	34791247	15	-	27260156	RDES	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.13901724728488157	[421]	[456,343,392,578]	-2	hSpCas9	negative selection	8501078
34792079	34792102	15	+	27260156	RDES	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.2675372275418999	[306]	[238,356,240,336]	-4	hSpCas9	negative selection	8501079
34793256	34793279	15	-	27260156	RDES	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.02458430984553961	[1024]	[1059,986,1285,1334]	0	hSpCas9	negative selection	8501080
34792558	34792581	15	-	27260156	PC3	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.48506300256263	[484]	[385,474,1320,863]	8	hSpCas9	negative selection	8558046
34791157	34791180	15	+	27260156	PC3	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.2958624591361968	[1127]	[595,670,1680,1084]	-6	hSpCas9	negative selection	8558047
34793248	34793271	15	+	27260156	PC3	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.36958648704135216	[364]	[317,311,1036,461]	7	hSpCas9	negative selection	8558048
34791224	34791247	15	-	27260156	PC3	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.2445830965244455	[421]	[228,261,619,441]	-5	hSpCas9	negative selection	8622329
34792079	34792102	15	+	27260156	PC3	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.05418668519879011	[306]	[168,309,400,370]	-1	hSpCas9	negative selection	8622330
34793256	34793279	15	-	27260156	PC3	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.3532522051622713	[1024]	[529,821,1127,884]	-7	hSpCas9	negative selection	8622331
34792558	34792581	15	-	27260156	PATU8988T	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.5670825788829472	[484]	[504,596,813,863]	8	hSpCas9	negative selection	8679297
34791157	34791180	15	+	27260156	PATU8988T	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.11318954463708097	[1127]	[1213,1070,779,971]	-2	hSpCas9	negative selection	8679298
34793248	34793271	15	+	27260156	PATU8988T	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	-0.03578759732020176	[364]	[384,388,238,370]	0	hSpCas9	negative selection	8679299
34791224	34791247	15	-	27260156	PATU8988T	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.4944641045495616	[421]	[243,379,191,356]	-7	hSpCas9	negative selection	8743580
34792079	34792102	15	+	27260156	PATU8988T	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.2333681386924844	[306]	[303,359,226,117]	-4	hSpCas9	negative selection	8743581
34793256	34793279	15	-	27260156	PATU8988T	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	0.15541118193843295	[1024]	[805,1100,1318,1189]	2	hSpCas9	negative selection	8743582
34792558	34792581	15	-	27260156	T47D	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.29425089250199654	[484]	[811,721,614,618]	6	hSpCas9	negative selection	8800548
34791157	34791180	15	+	27260156	T47D	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.33363499058263557	[1127]	[961,1133,1039,1025]	-6	hSpCas9	negative selection	8800549
34793248	34793271	15	+	27260156	T47D	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.17746309709633198	[364]	[539,459,464,459]	4	hSpCas9	negative selection	8800550
34791224	34791247	15	-	27260156	T47D	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.017751551986345038	[421]	[493,433,533,483]	0	hSpCas9	negative selection	8864831
34792079	34792102	15	+	27260156	T47D	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.2210788090733492	[306]	[339,310,281,293]	-5	hSpCas9	negative selection	8864832
34793256	34793279	15	-	27260156	T47D	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.08780372364530642	[1024]	[1194,1153,1046,1095]	-2	hSpCas9	negative selection	8864833
34792558	34792581	15	-	27260156	SU8686	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.5762636804142405	[484]	[611,688,615,1004]	8	hSpCas9	negative selection	8921799
34791157	34791180	15	+	27260156	SU8686	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.0188133012208882	[1127]	[986,1060,1203,1190]	0	hSpCas9	negative selection	8921800
34793248	34793271	15	+	27260156	SU8686	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.6271001299443275	[364]	[612,428,540,677]	9	hSpCas9	negative selection	8921801
34791224	34791247	15	-	27260156	SU8686	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.13033594444789065	[421]	[275,423,419,419]	-2	hSpCas9	negative selection	8986082
34792079	34792102	15	+	27260156	SU8686	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.10118218896690356	[306]	[227,318,249,346]	-2	hSpCas9	negative selection	8986083
34793256	34793279	15	-	27260156	SU8686	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.31151750420208346	[1024]	[763,596,1010,960]	-5	hSpCas9	negative selection	8986084
34792558	34792581	15	-	27260156	SKES1	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.2813035571801067	[484]	[598,728,616,436]	6	hSpCas9	negative selection	9043050
34791157	34791180	15	+	27260156	SKES1	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.39699675806827084	[1127]	[1043,783,742,856]	-7	hSpCas9	negative selection	9043051
34793248	34793271	15	+	27260156	SKES1	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.19107476944306162	[364]	[552,288,381,435]	4	hSpCas9	negative selection	9043052
34791224	34791247	15	-	27260156	SKES1	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.013484782561231673	[421]	[464,554,383,324]	0	hSpCas9	negative selection	9107333
34792079	34792102	15	+	27260156	SKES1	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.23006653873194827	[306]	[302,340,272,152]	-5	hSpCas9	negative selection	9107334
34793256	34793279	15	-	27260156	SKES1	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	0.02409983275403982	[1024]	[1123,1362,944,796]	0	hSpCas9	negative selection	9107335
34792558	34792581	15	-	27260156	TOV112D	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	1.2356287720500314	[484]	[503,753,544,2579]	9	hSpCas9	negative selection	9164301
34791157	34791180	15	+	27260156	TOV112D	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.2522164819201058	[1127]	[1019,1104,722,987]	-5	hSpCas9	negative selection	9164302
34793248	34793271	15	+	27260156	TOV112D	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	-0.2508701717475641	[364]	[226,495,162,379]	-5	hSpCas9	negative selection	9164303
34791224	34791247	15	-	27260156	TOV112D	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.1931380582632869	[421]	[345,701,468,457]	4	hSpCas9	negative selection	9228584
34792079	34792102	15	+	27260156	TOV112D	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.24499528191468478	[306]	[289,188,297,245]	-5	hSpCas9	negative selection	9228585
34793256	34793279	15	-	27260156	TOV112D	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.15567397028510954	[1024]	[644,1079,890,1079]	-3	hSpCas9	negative selection	9228586
34792558	34792581	15	-	27260156	TC71	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.3144961208922722	[484]	[588,699,523,786]	7	hSpCas9	negative selection	9285552
34791157	34791180	15	+	27260156	TC71	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.49925219129419285	[1127]	[715,827,844,1047]	-8	hSpCas9	negative selection	9285553
34793248	34793271	15	+	27260156	TC71	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.3444140579063533	[364]	[501,488,476,520]	7	hSpCas9	negative selection	9285554
34791224	34791247	15	-	27260156	TC71	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.02583328525000006	[421]	[548,431,381,411]	0	hSpCas9	negative selection	9349835
34792079	34792102	15	+	27260156	TC71	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.03489617723112348	[306]	[397,287,302,292]	-1	hSpCas9	negative selection	9349836
34793256	34793279	15	-	27260156	TC71	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.1161727600566762	[1024]	[1051,1018,904,1085]	-3	hSpCas9	negative selection	9349837
34792558	34792581	15	-	27260156	TC32	viability	TCCCCGGGCAGGCATTGTTCTGG	ACTC1	ENSG00000159251	0.43416951496432676	[484]	[606,457,805,650]	7	hSpCas9	negative selection	9406803
34791157	34791180	15	+	27260156	TC32	viability	TGCATACGATCAGCAATACCAGG	ACTC1	ENSG00000159251	-0.11410156032221686	[1127]	[886,925,1152,948]	-2	hSpCas9	negative selection	9406804
34793248	34793271	15	+	27260156	TC32	viability	TGGTACGGCCAGAAGCATACAGG	ACTC1	ENSG00000159251	0.3444947267362418	[364]	[374,423,560,384]	6	hSpCas9	negative selection	9406805
34791224	34791247	15	-	27260156	TC32	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.025685803363368426	[421]	[421,324,518,368]	0	hSpCas9	negative selection	9471086
34792079	34792102	15	+	27260156	TC32	viability	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.06388646449524171	[306]	[175,238,424,416]	1	hSpCas9	negative selection	9471087
34793256	34793279	15	-	27260156	TC32	viability	GTGCTATCCCTGTATGCTTCTGG	ACTC1	ENSG00000159251	-0.09796491740695412	[1024]	[1021,558,1125,997]	-2	hSpCas9	negative selection	9471088
34792079	34792102	15	+	27869803	HPAFII	viability after 27 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.35993211268719394	[481]	[149,236,NaN]	-3	hSpCas9	negative selection	9553290
34792400	34792423	15	+	27869803	HPAFII	viability after 27 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	0.8088612242636155	[350]	[409,250,NaN]	6	hSpCas9	negative selection	9553291
34794669	34794692	15	+	27869803	HPAFII	viability after 27 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.9508612782116117	[94]	[209,1,NaN]	7	hSpCas9	negative selection	9553292
34794673	34794696	15	+	27869803	HPAFII	viability after 27 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	-1.0242931672260442	[133]	[68,5,NaN]	-6	hSpCas9	negative selection	9553293
34794793	34794816	15	-	27869803	HPAFII	viability after 27 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	-0.2747043935121696	[664]	[294,283,NaN]	-2	hSpCas9	negative selection	9553294
34792079	34792102	15	+	27869803	HPAFII	viability after 15 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.14315476302139574	[481]	[658,517,NaN]	1	hSpCas9	negative selection	9635739
34792400	34792423	15	+	27869803	HPAFII	viability after 15 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	0.2006043187173278	[350]	[488,398,NaN]	2	hSpCas9	negative selection	9635740
34794669	34794692	15	+	27869803	HPAFII	viability after 15 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.2895257670840341	[94]	[191,82,NaN]	3	hSpCas9	negative selection	9635741
34794673	34794696	15	+	27869803	HPAFII	viability after 15 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	-0.006027176924822242	[133]	[283,55,NaN]	0	hSpCas9	negative selection	9635742
34794793	34794816	15	-	27869803	HPAFII	viability after 15 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	-0.11957034721187365	[664]	[655,658,NaN]	-1	hSpCas9	negative selection	9635743
34792079	34792102	15	+	27869803	ASPC1	viability after 36 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.15081313163260923	[1236]	[564,577,335]	1	hSpCas9	negative selection	9718188
34792400	34792423	15	+	27869803	ASPC1	viability after 36 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	0.49350694789444105	[825]	[737,363,201]	5	hSpCas9	negative selection	9718189
34794669	34794692	15	+	27869803	ASPC1	viability after 36 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-0.18376951786898932	[279]	[157,67,48]	-2	hSpCas9	negative selection	9718190
34794673	34794696	15	+	27869803	ASPC1	viability after 36 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	0.3967124248884632	[339]	[276,140,81]	4	hSpCas9	negative selection	9718191
34794793	34794816	15	-	27869803	ASPC1	viability after 36 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	-0.2035518920940862	[1472]	[967,249,231]	-2	hSpCas9	negative selection	9718192
34792079	34792102	15	+	27869803	PATU8988S	viability after 35 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.35515504284190336	[1060]	[367,725,NaN]	4	hSpCas9	negative selection	9800637
34792400	34792423	15	+	27869803	PATU8988S	viability after 35 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	0.12005845745245358	[823]	[432,287,NaN]	1	hSpCas9	negative selection	9800638
34794669	34794692	15	+	27869803	PATU8988S	viability after 35 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-0.20103865986065306	[334]	[60,173,NaN]	-2	hSpCas9	negative selection	9800639
34794673	34794696	15	+	27869803	PATU8988S	viability after 35 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	-1.2668719300021913	[307]	[72,29,NaN]	-8	hSpCas9	negative selection	9800640
34794793	34794816	15	-	27869803	PATU8988S	viability after 35 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	0.5483656433877562	[1337]	[819,755,NaN]	6	hSpCas9	negative selection	9800641
34792079	34792102	15	+	27869803	PATU8988S	viability after 31 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.002669385149961734	[1060]	[279,606,NaN]	0	hSpCas9	negative selection	9883086
34792400	34792423	15	+	27869803	PATU8988S	viability after 31 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	0.1341895907017212	[823]	[320,410,NaN]	1	hSpCas9	negative selection	9883087
34794669	34794692	15	+	27869803	PATU8988S	viability after 31 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.2431620863247131	[334]	[70,268,NaN]	3	hSpCas9	negative selection	9883088
34794673	34794696	15	+	27869803	PATU8988S	viability after 31 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	-0.8109428662611639	[307]	[91,41,NaN]	-7	hSpCas9	negative selection	9883089
34794793	34794816	15	-	27869803	PATU8988S	viability after 31 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	0.4315625132200118	[1337]	[686,760,NaN]	5	hSpCas9	negative selection	9883090
34792079	34792102	15	+	27869803	HPAFII	viability after 35 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	0.042491038097741685	[481]	[271,227,NaN]	0	hSpCas9	negative selection	9965535
34792400	34792423	15	+	27869803	HPAFII	viability after 35 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	0.9175505306457015	[350]	[329,341,NaN]	6	hSpCas9	negative selection	9965536
34794669	34794692	15	+	27869803	HPAFII	viability after 35 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	2.1841529623040814	[94]	[409,2,NaN]	9	hSpCas9	negative selection	9965537
34794673	34794696	15	+	27869803	HPAFII	viability after 35 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	-1.0995878078436365	[133]	[49,10,NaN]	-6	hSpCas9	negative selection	9965538
34794793	34794816	15	-	27869803	HPAFII	viability after 35 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	-0.15762385695922831	[664]	[274,331,NaN]	-1	hSpCas9	negative selection	9965539
34792079	34792102	15	+	27869803	HPAFII	viability after 31 days	CTACAACTCACCAATGAAGGAGG	ACTC1	ENSG00000159251	-0.08840125751068928	[481]	[263,243,NaN]	0	hSpCas9	negative selection	10047984
34792400	34792423	15	+	27869803	HPAFII	viability after 31 days	ACACTCACCAGTGGTGACAAAGG	ACTC1	ENSG00000159251	0.6918016192699423	[350]	[288,349,NaN]	5	hSpCas9	negative selection	10047985
34794669	34794692	15	+	27869803	HPAFII	viability after 31 days	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	1.5355787835952257	[94]	[289,6,NaN]	9	hSpCas9	negative selection	10047986
34794673	34794696	15	+	27869803	HPAFII	viability after 31 days	AGTTTACCTGGTGCCGCGGGCGG	ACTC1	ENSG00000159251	-0.07905739461239336	[133]	[108,29,NaN]	0	hSpCas9	negative selection	10047987
34794793	34794816	15	-	27869803	HPAFII	viability after 31 days	TGCCAAGATGTGTGACGACGAGG	ACTC1	ENSG00000159251	-0.23810326932851766	[664]	[325,305,NaN]	-2	hSpCas9	negative selection	10047988
34794767	34794790	15	+	28162770	P31FUJ	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	1.0063854594650474	[182]	[431]	9	hSpCas9	negative selection	10106348
34792545	34792568	15	-	28162770	P31FUJ	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	0.32938898864811944	[148]	[219]	3	hSpCas9	negative selection	10106349
34794701	34794724	15	+	28162770	P31FUJ	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	-0.4283530135321856	[141]	[123]	-4	hSpCas9	negative selection	10106350
34791158	34791181	15	+	28162770	P31FUJ	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	0.0675030787731884	[120]	[148]	0	hSpCas9	negative selection	10106351
34794669	34794692	15	+	28162770	P31FUJ	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.7606051182751926	[328]	[654]	8	hSpCas9	negative selection	10106352
34793284	34793307	15	+	28162770	P31FUJ	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-0.2633365725624907	[190]	[186]	-3	hSpCas9	negative selection	10106353
34792105	34792128	15	+	28162770	P31FUJ	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	-0.09815267771959682	[183]	[201]	-1	hSpCas9	negative selection	10106354
34791224	34791247	15	-	28162770	P31FUJ	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.014617883603650572	[897]	[1065]	0	hSpCas9	negative selection	10106355
34794754	34794777	15	-	28162770	P31FUJ	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	0.6028704837599762	[208]	[372]	7	hSpCas9	negative selection	10106356
34793249	34793272	15	+	28162770	P31FUJ	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.7316588143818059	[636]	[1242]	8	hSpCas9	negative selection	10106357
34794767	34794790	15	+	28162770	TF1	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	NaN	[NaN]	[216]	1	hSpCas9	negative selection	10275714
34792545	34792568	15	-	28162770	TF1	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	NaN	[NaN]	[157]	1	hSpCas9	negative selection	10275715
34794701	34794724	15	+	28162770	TF1	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	NaN	[NaN]	[197]	1	hSpCas9	negative selection	10275716
34791158	34791181	15	+	28162770	TF1	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	NaN	[NaN]	[47]	1	hSpCas9	negative selection	10275717
34794669	34794692	15	+	28162770	TF1	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	NaN	[NaN]	[534]	1	hSpCas9	negative selection	10275718
34793284	34793307	15	+	28162770	TF1	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	NaN	[NaN]	[151]	1	hSpCas9	negative selection	10275719
34792105	34792128	15	+	28162770	TF1	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	NaN	[NaN]	[27]	1	hSpCas9	negative selection	10275720
34791224	34791247	15	-	28162770	TF1	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	NaN	[NaN]	[823]	1	hSpCas9	negative selection	10275721
34794754	34794777	15	-	28162770	TF1	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	NaN	[NaN]	[168]	1	hSpCas9	negative selection	10275722
34793249	34793272	15	+	28162770	TF1	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	NaN	[NaN]	[816]	1	hSpCas9	negative selection	10275723
34794767	34794790	15	+	28162770	SKM1	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	1.0524674198941355	[53]	[197]	8	hSpCas9	negative selection	10445080
34792545	34792568	15	-	28162770	SKM1	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	1.4523607136133014	[36]	[178]	9	hSpCas9	negative selection	10445081
34794701	34794724	15	+	28162770	SKM1	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	-1.2914869813232257	[35]	[25]	-7	hSpCas9	negative selection	10445082
34791158	34791181	15	+	28162770	SKM1	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	-0.6335566086088953	[42]	[48]	-5	hSpCas9	negative selection	10445083
34794669	34794692	15	+	28162770	SKM1	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-0.48096478018693856	[89]	[113]	-4	hSpCas9	negative selection	10445084
34793284	34793307	15	+	28162770	SKM1	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-0.5048115221413063	[60]	[75]	-4	hSpCas9	negative selection	10445085
34792105	34792128	15	+	28162770	SKM1	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	0.17799830197799438	[32]	[65]	1	hSpCas9	negative selection	10445086
34791224	34791247	15	-	28162770	SKM1	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.8578487506167511	[151]	[486]	7	hSpCas9	negative selection	10445087
34794754	34794777	15	-	28162770	SKM1	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	0.9328858041414629	[31]	[107]	8	hSpCas9	negative selection	10445088
34793249	34793272	15	+	28162770	SKM1	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.4916587808817563	[139]	[347]	5	hSpCas9	negative selection	10445089
34794767	34794790	15	+	28162770	SKM1	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	1.0524674198941355	[53]	[197]	8	hSpCas9	negative selection	10614446
34792545	34792568	15	-	28162770	SKM1	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	1.4523607136133014	[36]	[178]	9	hSpCas9	negative selection	10614447
34794701	34794724	15	+	28162770	SKM1	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	-1.2914869813232257	[35]	[25]	-7	hSpCas9	negative selection	10614448
34791158	34791181	15	+	28162770	SKM1	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	-0.6335566086088953	[42]	[48]	-5	hSpCas9	negative selection	10614449
34794669	34794692	15	+	28162770	SKM1	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-0.48096478018693856	[89]	[113]	-4	hSpCas9	negative selection	10614450
34793284	34793307	15	+	28162770	SKM1	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-0.5048115221413063	[60]	[75]	-4	hSpCas9	negative selection	10614451
34792105	34792128	15	+	28162770	SKM1	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	0.17799830197799438	[32]	[65]	1	hSpCas9	negative selection	10614452
34791224	34791247	15	-	28162770	SKM1	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.8578487506167511	[151]	[486]	7	hSpCas9	negative selection	10614453
34794754	34794777	15	-	28162770	SKM1	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	0.9328858041414629	[31]	[107]	8	hSpCas9	negative selection	10614454
34793249	34793272	15	+	28162770	SKM1	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.4916587808817563	[139]	[347]	5	hSpCas9	negative selection	10614455
34794767	34794790	15	+	28162770	PL21	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	0.06889508121106763	[183]	[83]	0	hSpCas9	negative selection	10783812
34792545	34792568	15	-	28162770	PL21	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	-0.7339724498542227	[106]	[27]	-5	hSpCas9	negative selection	10783813
34794701	34794724	15	+	28162770	PL21	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	-0.3473481808131732	[151]	[51]	-2	hSpCas9	negative selection	10783814
34791158	34791181	15	+	28162770	PL21	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	-0.2512397318532441	[133]	[48]	-2	hSpCas9	negative selection	10783815
34794669	34794692	15	+	28162770	PL21	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	-0.1486641863894369	[297]	[116]	-1	hSpCas9	negative selection	10783816
34793284	34793307	15	+	28162770	PL21	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-1.1456352223524102	[243]	[47]	-6	hSpCas9	negative selection	10783817
34792105	34792128	15	+	28162770	PL21	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	-1.414570229625888	[97]	[15]	-7	hSpCas9	negative selection	10783818
34791224	34791247	15	-	28162770	PL21	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.7128530448238573	[620]	[442]	6	hSpCas9	negative selection	10783819
34794754	34794777	15	-	28162770	PL21	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	1.8204351883227572	[120]	[185]	9	hSpCas9	negative selection	10783820
34793249	34793272	15	+	28162770	PL21	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	-0.11582692215932533	[482]	[193]	-1	hSpCas9	negative selection	10783821
34794767	34794790	15	+	28162770	P31FUJ	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	1.0063854594650474	[182]	[431]	9	hSpCas9	negative selection	10953178
34792545	34792568	15	-	28162770	P31FUJ	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	0.32938898864811944	[148]	[219]	3	hSpCas9	negative selection	10953179
34794701	34794724	15	+	28162770	P31FUJ	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	-0.4283530135321856	[141]	[123]	-4	hSpCas9	negative selection	10953180
34791158	34791181	15	+	28162770	P31FUJ	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	0.0675030787731884	[120]	[148]	0	hSpCas9	negative selection	10953181
34794669	34794692	15	+	28162770	P31FUJ	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.7606051182751926	[328]	[654]	8	hSpCas9	negative selection	10953182
34793284	34793307	15	+	28162770	P31FUJ	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-0.2633365725624907	[190]	[186]	-3	hSpCas9	negative selection	10953183
34792105	34792128	15	+	28162770	P31FUJ	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	-0.09815267771959682	[183]	[201]	-1	hSpCas9	negative selection	10953184
34791224	34791247	15	-	28162770	P31FUJ	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.014617883603650572	[897]	[1065]	0	hSpCas9	negative selection	10953185
34794754	34794777	15	-	28162770	P31FUJ	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	0.6028704837599762	[208]	[372]	7	hSpCas9	negative selection	10953186
34793249	34793272	15	+	28162770	P31FUJ	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.7316588143818059	[636]	[1242]	8	hSpCas9	negative selection	10953187
34794767	34794790	15	+	28162770	OCIAML5	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	-0.05559996494912904	[113]	[197]	0	hSpCas9	negative selection	11122544
34792545	34792568	15	-	28162770	OCIAML5	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	0.28381685721777605	[80]	[177]	2	hSpCas9	negative selection	11122545
34794701	34794724	15	+	28162770	OCIAML5	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	0.1841536170487562	[58]	[120]	1	hSpCas9	negative selection	11122546
34791158	34791181	15	+	28162770	OCIAML5	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	-0.5546806602394262	[82]	[101]	-4	hSpCas9	negative selection	11122547
34794669	34794692	15	+	28162770	OCIAML5	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.6028971128276059	[146]	[402]	5	hSpCas9	negative selection	11122548
34793284	34793307	15	+	28162770	OCIAML5	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-1.3881194711042069	[144]	[99]	-7	hSpCas9	negative selection	11122549
34792105	34792128	15	+	28162770	OCIAML5	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	-1.828607598040008	[121]	[61]	-7	hSpCas9	negative selection	11122550
34791224	34791247	15	-	28162770	OCIAML5	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.3181822315090632	[494]	[1113]	2	hSpCas9	negative selection	11122551
34794754	34794777	15	-	28162770	OCIAML5	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	1.8894004155371502	[63]	[427]	9	hSpCas9	negative selection	11122552
34793249	34793272	15	+	28162770	OCIAML5	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.43292908323837076	[363]	[886]	4	hSpCas9	negative selection	11122553
34794767	34794790	15	+	28162770	EOL1	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	-0.19912659881602088	[352]	[161]	-1	hSpCas9	negative selection	11291910
34792545	34792568	15	-	28162770	EOL1	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	0.9615419790527361	[153]	[157]	8	hSpCas9	negative selection	11291911
34794701	34794724	15	+	28162770	EOL1	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	0.6918870147802594	[234]	[199]	6	hSpCas9	negative selection	11291912
34791158	34791181	15	+	28162770	EOL1	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	0.6740043099199374	[206]	[173]	6	hSpCas9	negative selection	11291913
34794669	34794692	15	+	28162770	EOL1	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.03442538934290795	[555]	[299]	0	hSpCas9	negative selection	11291914
34793284	34793307	15	+	28162770	EOL1	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-0.6188138246838486	[375]	[128]	-4	hSpCas9	negative selection	11291915
34792105	34792128	15	+	28162770	EOL1	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	-1.0754522284294656	[171]	[42]	-6	hSpCas9	negative selection	11291916
34791224	34791247	15	-	28162770	EOL1	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	1.0106257107000125	[796]	[845]	8	hSpCas9	negative selection	11291917
34794754	34794777	15	-	28162770	EOL1	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	-0.10319721891236977	[209]	[102]	-1	hSpCas9	negative selection	11291918
34793249	34793272	15	+	28162770	EOL1	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.18433469141657544	[592]	[354]	1	hSpCas9	negative selection	11291919
34794767	34794790	15	+	28162770	MOLM13	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	0.38988686954330565	[265]	[251]	3	hSpCas9	negative selection	11461276
34792545	34792568	15	-	28162770	MOLM13	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	-0.23597852444539635	[157]	[96]	-1	hSpCas9	negative selection	11461277
34794701	34794724	15	+	28162770	MOLM13	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	-1.3921346090259654	[264]	[72]	-6	hSpCas9	negative selection	11461278
34791158	34791181	15	+	28162770	MOLM13	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	-0.5995099037410079	[240]	[114]	-3	hSpCas9	negative selection	11461279
34794669	34794692	15	+	28162770	MOLM13	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.14512031021784544	[428]	[342]	1	hSpCas9	negative selection	11461280
34793284	34793307	15	+	28162770	MOLM13	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-0.42279392411192146	[342]	[184]	-3	hSpCas9	negative selection	11461281
34792105	34792128	15	+	28162770	MOLM13	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	-0.9029483138237299	[149]	[57]	-5	hSpCas9	negative selection	11461282
34791224	34791247	15	-	28162770	MOLM13	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.07085983141649765	[1034]	[785]	0	hSpCas9	negative selection	11461283
34794754	34794777	15	-	28162770	MOLM13	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	0.46788938154457876	[214]	[214]	3	hSpCas9	negative selection	11461284
34793249	34793272	15	+	28162770	MOLM13	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.9333247335273545	[653]	[902]	7	hSpCas9	negative selection	11461285
34794767	34794790	15	+	28162770	HEL	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	0.5201721897941016	[220]	[202]	4	hSpCas9	negative selection	11630642
34792545	34792568	15	-	28162770	HEL	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	0.7171636731269115	[169]	[178]	6	hSpCas9	negative selection	11630643
34794701	34794724	15	+	28162770	HEL	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	0.20515876407042494	[171]	[126]	1	hSpCas9	negative selection	11630644
34791158	34791181	15	+	28162770	HEL	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	-0.8709649855509772	[236]	[82]	-5	hSpCas9	negative selection	11630645
34794669	34794692	15	+	28162770	HEL	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.9297485106844909	[367]	[448]	7	hSpCas9	negative selection	11630646
34793284	34793307	15	+	28162770	HEL	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-0.4789770763993356	[308]	[141]	-3	hSpCas9	negative selection	11630647
34792105	34792128	15	+	28162770	HEL	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	-0.2641517636081616	[134]	[71]	-2	hSpCas9	negative selection	11630648
34791224	34791247	15	-	28162770	HEL	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.5831610229430313	[790]	[758]	5	hSpCas9	negative selection	11630649
34794754	34794777	15	-	28162770	HEL	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	-0.6131000724292331	[159]	[66]	-4	hSpCas9	negative selection	11630650
34793249	34793272	15	+	28162770	HEL	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.7300503918537256	[560]	[595]	6	hSpCas9	negative selection	11630651
34794767	34794790	15	+	28162770	MV411	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	-0.13107407247095437	[194]	[149]	-1	hSpCas9	negative selection	11800008
34792545	34792568	15	-	28162770	MV411	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	1.2309494279942061	[87]	[173]	9	hSpCas9	negative selection	11800009
34794701	34794724	15	+	28162770	MV411	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	1.0223709951480018	[134]	[230]	8	hSpCas9	negative selection	11800010
34791158	34791181	15	+	28162770	MV411	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	-0.8699193998553835	[127]	[58]	-5	hSpCas9	negative selection	11800011
34794669	34794692	15	+	28162770	MV411	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	1.0792623312904226	[308]	[549]	8	hSpCas9	negative selection	11800012
34793284	34793307	15	+	28162770	MV411	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-0.24495883120230832	[165]	[117]	-2	hSpCas9	negative selection	11800013
34792105	34792128	15	+	28162770	MV411	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	-0.2793103359930853	[84]	[58]	-2	hSpCas9	negative selection	11800014
34791224	34791247	15	-	28162770	MV411	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	1.240169550318736	[596]	[1187]	9	hSpCas9	negative selection	11800015
34794754	34794777	15	-	28162770	MV411	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	0.4729972511979062	[129]	[151]	4	hSpCas9	negative selection	11800016
34793249	34793272	15	+	28162770	MV411	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.04237321358631174	[399]	[346]	0	hSpCas9	negative selection	11800017
34794767	34794790	15	+	28162770	MONOMAC1	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	0.6563382392219631	[118]	[214]	6	hSpCas9	negative selection	11969374
34792545	34792568	15	-	28162770	MONOMAC1	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	0.9888296982517804	[79]	[181]	8	hSpCas9	negative selection	11969375
34794701	34794724	15	+	28162770	MONOMAC1	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	0.3334778696392262	[107]	[155]	3	hSpCas9	negative selection	11969376
34791158	34791181	15	+	28162770	MONOMAC1	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	0.9057739585242217	[87]	[188]	8	hSpCas9	negative selection	11969377
34794669	34794692	15	+	28162770	MONOMAC1	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.29716018973842023	[163]	[230]	3	hSpCas9	negative selection	11969378
34793284	34793307	15	+	28162770	MONOMAC1	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	0.036276860654240295	[187]	[220]	0	hSpCas9	negative selection	11969379
34792105	34792128	15	+	28162770	MONOMAC1	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	-0.10683903808797535	[61]	[65]	-1	hSpCas9	negative selection	11969380
34791224	34791247	15	-	28162770	MONOMAC1	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	-0.1380013767626016	[406]	[423]	-1	hSpCas9	negative selection	11969381
34794754	34794777	15	-	28162770	MONOMAC1	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	-0.17627828689275638	[68]	[69]	-1	hSpCas9	negative selection	11969382
34793249	34793272	15	+	28162770	MONOMAC1	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.21551110019359232	[289]	[385]	2	hSpCas9	negative selection	11969383
34794767	34794790	15	+	28162770	OCIAML2	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	0.41201322411968	[39]	[294]	4	hSpCas9	negative selection	12138740
34792545	34792568	15	-	28162770	OCIAML2	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	1.462255978899302	[21]	[335]	9	hSpCas9	negative selection	12138741
34794701	34794724	15	+	28162770	OCIAML2	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	-0.5246696649550503	[33]	[130]	-4	hSpCas9	negative selection	12138742
34791158	34791181	15	+	28162770	OCIAML2	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	1.3911728808378192	[12]	[188]	9	hSpCas9	negative selection	12138743
34794669	34794692	15	+	28162770	OCIAML2	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	0.11877858051018697	[53]	[324]	1	hSpCas9	negative selection	12138744
34793284	34793307	15	+	28162770	OCIAML2	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-0.2396753904022891	[35]	[168]	-2	hSpCas9	negative selection	12138745
34792105	34792128	15	+	28162770	OCIAML2	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	-1.509103973056797	[18]	[36]	-7	hSpCas9	negative selection	12138746
34791224	34791247	15	-	28162770	OCIAML2	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.2536566348532987	[119]	[792]	2	hSpCas9	negative selection	12138747
34794754	34794777	15	-	28162770	OCIAML2	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	0.3287763436999519	[25]	[180]	3	hSpCas9	negative selection	12138748
34793249	34793272	15	+	28162770	OCIAML2	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.46523983733812313	[68]	[527]	4	hSpCas9	negative selection	12138749
34794767	34794790	15	+	28162770	OCIAML3	viability	GTTGTCGCACACCAGGGCGGTGG	ACTC1	ENSG00000159251	1.2913497937347143	[35]	[265]	9	hSpCas9	negative selection	12308106
34792545	34792568	15	-	28162770	OCIAML3	viability	ATTGTTCTGGACTCTGGGGATGG	ACTC1	ENSG00000159251	-0.0691661320405779	[48]	[140]	0	hSpCas9	negative selection	12308107
34794701	34794724	15	+	28162770	OCIAML3	viability	GATGGACGGGAAGACAGCGCGGG	ACTC1	ENSG00000159251	-1.3045010231291785	[53]	[65]	-7	hSpCas9	negative selection	12308108
34791158	34791181	15	+	28162770	OCIAML3	viability	GCATACGATCAGCAATACCAGGG	ACTC1	ENSG00000159251	0.41758033395104877	[30]	[124]	4	hSpCas9	negative selection	12308109
34794669	34794692	15	+	28162770	OCIAML3	viability	GGGAAGTTTACCTGGTGCCGCGG	ACTC1	ENSG00000159251	1.1278510614518347	[71]	[474]	8	hSpCas9	negative selection	12308110
34793284	34793307	15	+	28162770	OCIAML3	viability	GGATGGCCACGTACATGGCAGGG	ACTC1	ENSG00000159251	-0.5723125692248441	[65]	[133]	-4	hSpCas9	negative selection	12308111
34792105	34792128	15	+	28162770	OCIAML3	viability	GGAAGAGTGTCTCAGGACAGCGG	ACTC1	ENSG00000159251	0.5612705851537478	[43]	[195]	5	hSpCas9	negative selection	12308112
34791224	34791247	15	-	28162770	OCIAML3	viability	GTGTGACATTGATATCCGCAAGG	ACTC1	ENSG00000159251	0.5927448696950315	[160]	[732]	5	hSpCas9	negative selection	12308113
34794754	34794777	15	-	28162770	OCIAML3	viability	GTGCGACAACGGCTCTGGGCTGG	ACTC1	ENSG00000159251	-0.6720101523254363	[37]	[71]	-5	hSpCas9	negative selection	12308114
34793249	34793272	15	+	28162770	OCIAML3	viability	GGTACGGCCAGAAGCATACAGGG	ACTC1	ENSG00000159251	0.7582030214992419	[131]	[673]	6	hSpCas9	negative selection	12308115