Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:64431
• Symbol:ACTR6
• Description:actin related protein 6

DataSource: http://genomecrispr.dkfz.de/#!/results/ACTR6

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
100200848	100200871	12	+	26472758	Jiyoye	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-2.322558643429257	[198]	[29]	-8	hSpCas9	negative selection	2245
100200876	100200899	12	+	26472758	Jiyoye	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-1.5613136457489092	[316]	[80]	-7	hSpCas9	negative selection	2250
100200848	100200871	12	+	26472758	KBM7	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-2.6468306566637514	[709,873]	[90,32]	-9	hSpCas9	negative selection	193363
100200876	100200899	12	+	26472758	KBM7	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.6448455190241228	[688,664]	[256,156]	-5	hSpCas9	negative selection	193368
100200848	100200871	12	+	26472758	Raji	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.089013677429904	[219]	[23]	-7	hSpCas9	negative selection	384481
100200876	100200899	12	+	26472758	Raji	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.5177070780528662	[400]	[64]	-4	hSpCas9	negative selection	384486
100200848	100200871	12	+	26472758	K562	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.6906425406332324	[542]	[141]	-7	hSpCas9	negative selection	575599
100200876	100200899	12	+	26472758	K562	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.8404701699200663	[559]	[263]	-5	hSpCas9	negative selection	575604
100199179	100199202	12	+	26627737	DLD1	viability	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.2264491383635563	[482]	[77,97,198]	-2	hSpCas9	negative selection	781683
100199188	100199211	12	+	26627737	DLD1	viability	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	0.3420742305924762	[240]	[140,39,101]	3	hSpCas9	negative selection	781684
100199179	100199202	12	+	26627737	GBM cells	viability after 5 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.6204602842078938	[257]	[73,105]	-7	hSpCas9	negative selection	863998
100199188	100199211	12	+	26627737	GBM cells	viability after 5 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	-0.5552620183001165	[136]	[65,33]	-7	hSpCas9	negative selection	863999
100199179	100199202	12	+	26627737	GBM cells	viability after 13 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.6129606281089541	[257]	[117,69]	-6	hSpCas9	negative selection	946313
100199188	100199211	12	+	26627737	GBM cells	viability after 13 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	-0.7271436707891672	[136]	[61,30]	-7	hSpCas9	negative selection	946314
100199179	100199202	12	+	26627737	GBM cells	viability after 21 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.776573140787364	[257]	[85,77]	-6	hSpCas9	negative selection	1028628
100199188	100199211	12	+	26627737	GBM cells	viability after 21 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	-0.8665159685631936	[136]	[44,36]	-6	hSpCas9	negative selection	1028629
100199179	100199202	12	+	26627737	RPE1	viability after 9 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.7550175666517163	[824]	[142,165]	-5	hSpCas9	negative selection	1110943
100199188	100199211	12	+	26627737	RPE1	viability after 9 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	-0.5186730336053553	[259]	[58,53]	-4	hSpCas9	negative selection	1110944
100199179	100199202	12	+	26627737	RPE1	viability after 12 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.31640546649364254	[824]	[194,159]	-2	hSpCas9	negative selection	1193258
100199188	100199211	12	+	26627737	RPE1	viability after 12 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	-0.2948134234612252	[259]	[54,58]	-2	hSpCas9	negative selection	1193259
100199179	100199202	12	+	26627737	RPE1	viability after 15 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.18568450488497076	[824]	[306,106]	-1	hSpCas9	negative selection	1275573
100199188	100199211	12	+	26627737	RPE1	viability after 15 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	0.2582933107443188	[259]	[145,31]	1	hSpCas9	negative selection	1275574
100199179	100199202	12	+	26627737	RPE1	viability after 18 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.05118446711147248	[824]	[225,202]	0	hSpCas9	negative selection	1357888
100199188	100199211	12	+	26627737	RPE1	viability after 18 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	0.0293218157711832	[259]	[132,5]	0	hSpCas9	negative selection	1357889
100199179	100199202	12	+	26627737	HeLa	viability after 8 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.7838619315118119	[634]	[202,144,143]	-7	hSpCas9	negative selection	1440203
100199188	100199211	12	+	26627737	HeLa	viability after 8 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	0.7431415697568616	[148]	[120,108,98]	6	hSpCas9	negative selection	1440204
100199179	100199202	12	+	26627737	HeLa	viability after 12 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.6635706893280626	[634]	[79,113,305]	-5	hSpCas9	negative selection	1522518
100199188	100199211	12	+	26627737	HeLa	viability after 12 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	0.9353909455357872	[148]	[129,85,140]	7	hSpCas9	negative selection	1522519
100199179	100199202	12	+	26627737	HeLa	viability after 15 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.23335531376547974	[634]	[243,151,266]	-2	hSpCas9	negative selection	1604833
100199188	100199211	12	+	26627737	HeLa	viability after 15 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	0.49732163942504537	[148]	[99,18,141]	4	hSpCas9	negative selection	1604834
100199179	100199202	12	+	26627737	HeLa	viability after 18 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.28207600498402696	[634]	[150,123,266]	-2	hSpCas9	negative selection	1687148
100199188	100199211	12	+	26627737	HeLa	viability after 18 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	0.4561781427503717	[148]	[62,14,141]	4	hSpCas9	negative selection	1687149
100199179	100199202	12	+	26627737	HCT116	viability after 6 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	0.7732796235182617	[835]	[203,235]	4	hSpCas9	negative selection	1769463
100199188	100199211	12	+	26627737	HCT116	viability after 6 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	3.1317065562511432	[275]	[893,96]	9	hSpCas9	negative selection	1769464
100199179	100199202	12	+	26627737	HCT116	viability after 8 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	0.04246758509736033	[272]	[243,119,102]	0	hSpCas9	negative selection	1851778
100199188	100199211	12	+	26627737	HCT116	viability after 8 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	1.5209148047352157	[69]	[189,74,68]	9	hSpCas9	negative selection	1851779
100199179	100199202	12	+	26627737	HCT116	viability after 9 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.6229084814667114	[835]	[173,121]	-4	hSpCas9	negative selection	1934093
100199188	100199211	12	+	26627737	HCT116	viability after 9 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	0.5346489268981773	[275]	[27,168]	4	hSpCas9	negative selection	1934094
100199179	100199202	12	+	26627737	HCT116	viability after 12 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.40738054963765447	[272]	[105,119,98]	-4	hSpCas9	negative selection	2016408
100199188	100199211	12	+	26627737	HCT116	viability after 12 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	1.8624930164626103	[69]	[171,176,49]	9	hSpCas9	negative selection	2016409
100199179	100199202	12	+	26627737	HCT116	viability after 15 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	0.07590695382914256	[272]	[250,73,180]	0	hSpCas9	negative selection	2098723
100199188	100199211	12	+	26627737	HCT116	viability after 15 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	1.477790581533358	[69]	[220,84,43]	9	hSpCas9	negative selection	2098724
100199179	100199202	12	+	26627737	HCT116	viability after 18 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.43141180344366137	[272]	[142,75,74]	-4	hSpCas9	negative selection	2181038
100199188	100199211	12	+	26627737	HCT116	viability after 18 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	2.3503866607548263	[69]	[328,88,101]	9	hSpCas9	negative selection	2181039
100202705	100202728	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	AAATTAGCCGGGCGTAGTGGCAG	ACTR6	ENSG00000075089	-0.8514681672512537	[13,97]	[5,6]	-5	dCas9-VP64	positive selection	2404247
100199968	100199991	12	-	25494202	A375	resistance to PLX-4720 (puromycin)	CGGGCTAGGACAACTGCCAACGG	ACTR6	ENSG00000075089	0.5450750798689608	[50,54]	[13,19]	2	dCas9-VP64	positive selection	2454833
100199919	100199942	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	CTCAGGCGCTCAAAGTGGCCTGG	ACTR6	ENSG00000075089	-0.5506557994189473	[80,84]	[7,15]	-3	dCas9-VP64	positive selection	2454834
100199937	100199960	12	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGGGGCGTTCTACAAATTCCAGG	ACTR6	ENSG00000075089	-0.6408067824469943	[46,389]	[5,57]	-3	dCas9-VP64	positive selection	2454835
100202705	100202728	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	AAATTAGCCGGGCGTAGTGGCAG	ACTR6	ENSG00000075089	0.40157018881037165	[169,39]	[83,8]	3	dCas9-VP64	positive selection	2499502
100199968	100199991	12	-	25494202	A375	resistance to PLX-4720 (zeocin)	CGGGCTAGGACAACTGCCAACGG	ACTR6	ENSG00000075089	2.5361582939269147	[108,108]	[397,29]	9	dCas9-VP64	positive selection	2550088
100199919	100199942	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	CTCAGGCGCTCAAAGTGGCCTGG	ACTR6	ENSG00000075089	-0.6556571983581735	[9,111]	[6,16]	-6	dCas9-VP64	positive selection	2550089
100199937	100199960	12	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGGGGCGTTCTACAAATTCCAGG	ACTR6	ENSG00000075089	-0.8001055825316303	[140,203]	[47,16]	-7	dCas9-VP64	positive selection	2550090
100200969	100200992	12	+	27260157	DLD1	viability	CATGTGCTACGTTTCATCTCCGG	ACTR6	ENSG00000075089	0.05377080079925	[]	[]	3	hSpCas9	negative selection	2576227
100200937	100200960	12	-	27260157	DLD1	viability	GGCGTATATATCTTGTCCCTCGG	ACTR6	ENSG00000075089	0.174933181554451	[]	[]	3	hSpCas9	negative selection	2577950
100200988	100201011	12	-	27260157	DLD1	viability	GTCTGCAGTTCATTGATGTCCGG	ACTR6	ENSG00000075089	-0.491380514536214	[]	[]	-4	hSpCas9	negative selection	2578538
100201034	100201057	12	-	27260157	DLD1	viability	CTCCAACCAGGGAATCCCTCTGG	ACTR6	ENSG00000075089	0.669585212169196	[]	[]	8	hSpCas9	negative selection	2580591
100199147	100199170	12	+	27260157	DLD1	viability	AGTTCTAAAGGAGGCCCCTGGGG	ACTR6	ENSG00000075089	-0.484835462415315	[]	[]	-4	hSpCas9	negative selection	2580950
100201023	100201046	12	-	27260157	DLD1	viability	GAATCCCTCTGGCTAAGTCAGGG	ACTR6	ENSG00000075089	-0.94218447697598	[]	[]	-6	hSpCas9	negative selection	2585686
100201012	100201035	12	-	27260157	DLD1	viability	GCTAAGTCAGGGCCGCGCGGGGG	ACTR6	ENSG00000075089	-0.964063842370994	[]	[]	-7	hSpCas9	negative selection	2606581
100201018	100201041	12	+	27260157	DLD1	viability	CGCGGCCCTGACTTAGCCAGAGG	ACTR6	ENSG00000075089	-0.612853604869275	[]	[]	-5	hSpCas9	negative selection	2607574
100199146	100199169	12	+	27260157	DLD1	viability	GAGTTCTAAAGGAGGCCCCTGGG	ACTR6	ENSG00000075089	-0.383385267758478	[]	[]	-3	hSpCas9	negative selection	2609353
100200848	100200871	12	+	27260157	DLD1	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-3.28035546998126	[]	[]	-9	hSpCas9	negative selection	2620204
100200958	100200981	12	-	27260157	DLD1	viability	ACGTAGCACATGAAACCACTAGG	ACTR6	ENSG00000075089	-0.0933247319337192	[]	[]	0	hSpCas9	negative selection	2621356
100201028	100201051	12	+	27260157	DLD1	viability	ACTTAGCCAGAGGGATTCCCTGG	ACTR6	ENSG00000075089	-0.323291309687637	[]	[]	-3	hSpCas9	negative selection	2641144
100200859	100200882	12	-	27260157	DLD1	viability	AGCTCCATTATCCAGCACTAAGG	ACTR6	ENSG00000075089	-2.32530227992968	[]	[]	-9	hSpCas9	negative selection	2647580
100200969	100200992	12	+	27260157	HT1080	viability	CATGTGCTACGTTTCATCTCCGG	ACTR6	ENSG00000075089	0.212450095719125	[]	[]	2	hSpCas9	negative selection	2652357
100200937	100200960	12	-	27260157	HT1080	viability	GGCGTATATATCTTGTCCCTCGG	ACTR6	ENSG00000075089	-0.578900542380541	[]	[]	-7	hSpCas9	negative selection	2654080
100200988	100201011	12	-	27260157	HT1080	viability	GTCTGCAGTTCATTGATGTCCGG	ACTR6	ENSG00000075089	0.975681239865308	[]	[]	7	hSpCas9	negative selection	2654668
100201034	100201057	12	-	27260157	HT1080	viability	CTCCAACCAGGGAATCCCTCTGG	ACTR6	ENSG00000075089	-0.219811603748484	[]	[]	0	hSpCas9	negative selection	2656721
100199147	100199170	12	+	27260157	HT1080	viability	AGTTCTAAAGGAGGCCCCTGGGG	ACTR6	ENSG00000075089	-0.971915931830308	[]	[]	-8	hSpCas9	negative selection	2657080
100201023	100201046	12	-	27260157	HT1080	viability	GAATCCCTCTGGCTAAGTCAGGG	ACTR6	ENSG00000075089	-0.295325702868925	[]	[]	-7	hSpCas9	negative selection	2661816
100201012	100201035	12	-	27260157	HT1080	viability	GCTAAGTCAGGGCCGCGCGGGGG	ACTR6	ENSG00000075089	-2.47240132678421	[]	[]	-9	hSpCas9	negative selection	2682711
100201018	100201041	12	+	27260157	HT1080	viability	CGCGGCCCTGACTTAGCCAGAGG	ACTR6	ENSG00000075089	-0.859882592586673	[]	[]	-8	hSpCas9	negative selection	2683704
100199146	100199169	12	+	27260157	HT1080	viability	GAGTTCTAAAGGAGGCCCCTGGG	ACTR6	ENSG00000075089	-0.0904383135848066	[]	[]	0	hSpCas9	negative selection	2685483
100200848	100200871	12	+	27260157	HT1080	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-2.09305294918369	[]	[]	-9	hSpCas9	negative selection	2696334
100200958	100200981	12	-	27260157	HT1080	viability	ACGTAGCACATGAAACCACTAGG	ACTR6	ENSG00000075089	-0.211196011234832	[]	[]	0	hSpCas9	negative selection	2697486
100201028	100201051	12	+	27260157	HT1080	viability	ACTTAGCCAGAGGGATTCCCTGG	ACTR6	ENSG00000075089	-1.15364593432321	[]	[]	-8	hSpCas9	negative selection	2717274
100200859	100200882	12	-	27260157	HT1080	viability	AGCTCCATTATCCAGCACTAAGG	ACTR6	ENSG00000075089	-2.50884147871159	[]	[]	-9	hSpCas9	negative selection	2723710
100200969	100200992	12	+	27260157	MKN45	viability	CATGTGCTACGTTTCATCTCCGG	ACTR6	ENSG00000075089	0.000636096733821711	[]	[]	0	hSpCas9	negative selection	2728487
100200937	100200960	12	-	27260157	MKN45	viability	GGCGTATATATCTTGTCCCTCGG	ACTR6	ENSG00000075089	-2.06088230963872	[]	[]	-9	hSpCas9	negative selection	2730210
100200988	100201011	12	-	27260157	MKN45	viability	GTCTGCAGTTCATTGATGTCCGG	ACTR6	ENSG00000075089	1.33251950933219	[]	[]	9	hSpCas9	negative selection	2730798
100201034	100201057	12	-	27260157	MKN45	viability	CTCCAACCAGGGAATCCCTCTGG	ACTR6	ENSG00000075089	-0.146250314486247	[]	[]	0	hSpCas9	negative selection	2732851
100199147	100199170	12	+	27260157	MKN45	viability	AGTTCTAAAGGAGGCCCCTGGGG	ACTR6	ENSG00000075089	-0.698141677590718	[]	[]	-7	hSpCas9	negative selection	2733210
100201023	100201046	12	-	27260157	MKN45	viability	GAATCCCTCTGGCTAAGTCAGGG	ACTR6	ENSG00000075089	-0.735678403845945	[]	[]	-7	hSpCas9	negative selection	2737946
100201012	100201035	12	-	27260157	MKN45	viability	GCTAAGTCAGGGCCGCGCGGGGG	ACTR6	ENSG00000075089	-1.06455330910777	[]	[]	-8	hSpCas9	negative selection	2758841
100201018	100201041	12	+	27260157	MKN45	viability	CGCGGCCCTGACTTAGCCAGAGG	ACTR6	ENSG00000075089	-1.55149543097319	[]	[]	-9	hSpCas9	negative selection	2759834
100199146	100199169	12	+	27260157	MKN45	viability	GAGTTCTAAAGGAGGCCCCTGGG	ACTR6	ENSG00000075089	0.921136187567688	[]	[]	8	hSpCas9	negative selection	2761613
100200848	100200871	12	+	27260157	MKN45	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.71859111506409	[]	[]	-9	hSpCas9	negative selection	2772464
100200958	100200981	12	-	27260157	MKN45	viability	ACGTAGCACATGAAACCACTAGG	ACTR6	ENSG00000075089	0.138514438022279	[]	[]	5	hSpCas9	negative selection	2773616
100201028	100201051	12	+	27260157	MKN45	viability	ACTTAGCCAGAGGGATTCCCTGG	ACTR6	ENSG00000075089	-0.0942624062265332	[]	[]	0	hSpCas9	negative selection	2793404
100200859	100200882	12	-	27260157	MKN45	viability	AGCTCCATTATCCAGCACTAAGG	ACTR6	ENSG00000075089	-2.87453110946455	[]	[]	-9	hSpCas9	negative selection	2799840
100200969	100200992	12	+	27260157	RKO	viability	CATGTGCTACGTTTCATCTCCGG	ACTR6	ENSG00000075089	-0.50215328280985	[]	[]	-6	hSpCas9	negative selection	2804617
100200937	100200960	12	-	27260157	RKO	viability	GGCGTATATATCTTGTCCCTCGG	ACTR6	ENSG00000075089	-1.85897515696344	[]	[]	-9	hSpCas9	negative selection	2806340
100200988	100201011	12	-	27260157	RKO	viability	GTCTGCAGTTCATTGATGTCCGG	ACTR6	ENSG00000075089	0.734026527305691	[]	[]	8	hSpCas9	negative selection	2806928
100201034	100201057	12	-	27260157	RKO	viability	CTCCAACCAGGGAATCCCTCTGG	ACTR6	ENSG00000075089	0.0994970182502255	[]	[]	0	hSpCas9	negative selection	2808981
100199147	100199170	12	+	27260157	RKO	viability	AGTTCTAAAGGAGGCCCCTGGGG	ACTR6	ENSG00000075089	-0.612281596215784	[]	[]	-7	hSpCas9	negative selection	2809340
100201023	100201046	12	-	27260157	RKO	viability	GAATCCCTCTGGCTAAGTCAGGG	ACTR6	ENSG00000075089	-0.611678011152878	[]	[]	-7	hSpCas9	negative selection	2814076
100201012	100201035	12	-	27260157	RKO	viability	GCTAAGTCAGGGCCGCGCGGGGG	ACTR6	ENSG00000075089	-0.299333249288747	[]	[]	-6	hSpCas9	negative selection	2834971
100201018	100201041	12	+	27260157	RKO	viability	CGCGGCCCTGACTTAGCCAGAGG	ACTR6	ENSG00000075089	-0.74953206054393	[]	[]	-7	hSpCas9	negative selection	2835964
100199146	100199169	12	+	27260157	RKO	viability	GAGTTCTAAAGGAGGCCCCTGGG	ACTR6	ENSG00000075089	0.661255207517511	[]	[]	3	hSpCas9	negative selection	2837743
100200848	100200871	12	+	27260157	RKO	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-2.88228947587275	[]	[]	-9	hSpCas9	negative selection	2848594
100200958	100200981	12	-	27260157	RKO	viability	ACGTAGCACATGAAACCACTAGG	ACTR6	ENSG00000075089	-0.225905675117732	[]	[]	-1	hSpCas9	negative selection	2849746
100201028	100201051	12	+	27260157	RKO	viability	ACTTAGCCAGAGGGATTCCCTGG	ACTR6	ENSG00000075089	-0.0896951892726435	[]	[]	0	hSpCas9	negative selection	2869534
100200859	100200882	12	-	27260157	RKO	viability	AGCTCCATTATCCAGCACTAAGG	ACTR6	ENSG00000075089	-1.96971256116153	[]	[]	-9	hSpCas9	negative selection	2875970
100200969	100200992	12	+	27260157	SF268	viability	CATGTGCTACGTTTCATCTCCGG	ACTR6	ENSG00000075089	-0.816090776464173	[]	[]	-6	hSpCas9	negative selection	2880747
100200937	100200960	12	-	27260157	SF268	viability	GGCGTATATATCTTGTCCCTCGG	ACTR6	ENSG00000075089	0.077727773598309	[]	[]	0	hSpCas9	negative selection	2882470
100200988	100201011	12	-	27260157	SF268	viability	GTCTGCAGTTCATTGATGTCCGG	ACTR6	ENSG00000075089	-0.290601750490341	[]	[]	-2	hSpCas9	negative selection	2883058
100201034	100201057	12	-	27260157	SF268	viability	CTCCAACCAGGGAATCCCTCTGG	ACTR6	ENSG00000075089	-0.120853669820032	[]	[]	-1	hSpCas9	negative selection	2885111
100199147	100199170	12	+	27260157	SF268	viability	AGTTCTAAAGGAGGCCCCTGGGG	ACTR6	ENSG00000075089	-0.280641964417052	[]	[]	-2	hSpCas9	negative selection	2885470
100201023	100201046	12	-	27260157	SF268	viability	GAATCCCTCTGGCTAAGTCAGGG	ACTR6	ENSG00000075089	0.0306560887227549	[]	[]	0	hSpCas9	negative selection	2890206
100201012	100201035	12	-	27260157	SF268	viability	GCTAAGTCAGGGCCGCGCGGGGG	ACTR6	ENSG00000075089	-0.628781175500012	[]	[]	-5	hSpCas9	negative selection	2911101
100201018	100201041	12	+	27260157	SF268	viability	CGCGGCCCTGACTTAGCCAGAGG	ACTR6	ENSG00000075089	-0.734377275797639	[]	[]	-5	hSpCas9	negative selection	2912094
100199146	100199169	12	+	27260157	SF268	viability	GAGTTCTAAAGGAGGCCCCTGGG	ACTR6	ENSG00000075089	-0.463265026007811	[]	[]	-4	hSpCas9	negative selection	2913873
100200848	100200871	12	+	27260157	SF268	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.69912035299912	[]	[]	-8	hSpCas9	negative selection	2924724
100200958	100200981	12	-	27260157	SF268	viability	ACGTAGCACATGAAACCACTAGG	ACTR6	ENSG00000075089	-0.0405594449099713	[]	[]	0	hSpCas9	negative selection	2925876
100201028	100201051	12	+	27260157	SF268	viability	ACTTAGCCAGAGGGATTCCCTGG	ACTR6	ENSG00000075089	0.255248023769731	[]	[]	4	hSpCas9	negative selection	2945664
100200859	100200882	12	-	27260157	SF268	viability	AGCTCCATTATCCAGCACTAAGG	ACTR6	ENSG00000075089	-2.59588719924701	[]	[]	-9	hSpCas9	negative selection	2952100
100200849	100200872	12	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.7894012998276879	[3,3]	[2,0]	-8	hSpCas9	positive selection	2968768
100200849	100200872	12	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.07319281066384017	[3,3]	[3,0]	-1	hSpCas9	positive selection	3036626
100200876	100200899		+	24336571	A375	resistance to PLX after 7 days	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	0.30992354466036676	[3,4]	[5,4]	8	hSpCas9	positive selection	3160159
100200848	100200871		+	24336571	A375	resistance to PLX after 7 days	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.10645002601298958	[9,6]	[7,6]	-3	hSpCas9	positive selection	3160170
100200876	100200899		+	24336571	A375	resistance to PLX after 14 days	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	0.24714714918496106	[3,3]	[1,1]	2	hSpCas9	positive selection	3217952
100200848	100200871		+	24336571	A375	resistance to PLX after 14 days	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	0.4714472715678131	[5,3]	[2,2]	4	hSpCas9	positive selection	3217963
100200876	100200899		+	24336571	A375	viability after 7 days	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.7019249543655508	[7]	[3,4]	-7	hSpCas9	negative selection	3275745
100200848	100200871		+	24336571	A375	viability after 7 days	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.7729810484450172	[15]	[9,6]	-8	hSpCas9	negative selection	3275756
100200876	100200899		+	24336571	A375	viability after 14 days	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.941101228163344	[7]	[3,3]	-8	hSpCas9	negative selection	3333538
100200848	100200871		+	24336571	A375	viability after 14 days	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.461369403949783	[15]	[5,3]	-9	hSpCas9	negative selection	3333549
100200876	100200899	12	+	27383988	293T	resistance to West Nile virus (flavivirus)	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	0.679551845445072	[98,91]	[0,0]	3	hSpCas9	positive selection	3335454
100200848	100200871	12	+	27383988	293T	resistance to West Nile virus (flavivirus)	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.8508223877791445	[264,286]	[0,0]	-6	hSpCas9	positive selection	3335455
100200848	100200871	12	+	26780180	HT29	viability (Avana library 4 designs)	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	6.82794678443148	[]	[]	9	hSpCas9	negative selection	3404718
100200848	100200871	12	+	26780180	A375	viability (Avana lentiCRISPRv2)	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-12.8193919736146	[]	[]	-8	hSpCas9	negative selection	3476391
100200876	100200899	12	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.495104137077801	[]	[]	0	hSpCas9	negative selection	3476392
100200848	100200871	12	+	26780180	A375	viability (Avana lentiGuide)	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	28.1881914938003	[]	[]	9	hSpCas9	negative selection	3585050
100200876	100200899	12	+	26780180	A375	viability (Avana lentiGuide)	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	12.7433489340035	[]	[]	7	hSpCas9	negative selection	3585051
100200848	100200871	12	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.46931072997046236	[5]	[3,3]	-6	hSpCas9	positive selection	3693709
100200876	100200899	12	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.13162529653307006	[4]	[4,2]	-2	hSpCas9	positive selection	3693710
100200848	100200871	12	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.0138789687201903	[6]	[2,1]	-8	hSpCas9	positive selection	3802316
100200876	100200899	12	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.21395643398440395	[4]	[3,2]	-3	hSpCas9	positive selection	3802317
100200876	100200899	12	+	26780180	A375	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	1.27249929941638	[]	[]	7	hSpCas9	negative selection	3910918
100200848	100200871	12	+	26780180	A375	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	2.88882058717139	[]	[]	9	hSpCas9	negative selection	3910919
100200876	100200899	12	+	26780180	HT29	viability (GeCKOv2 library)	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	1.3532582160181	[]	[]	7	hSpCas9	negative selection	4018884
100200848	100200871	12	+	26780180	HT29	viability (GeCKOv2 library)	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	3.52711152241304	[]	[]	9	hSpCas9	negative selection	4018885
100200876	100200899	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.6450474561748875	[3]	[1,0]	-9	hSpCas9	positive selection	4188227
100200848	100200871	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.7867559849668109	[3]	[0,1]	-9	hSpCas9	positive selection	4188238
100200876	100200899	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.6502529614603892	[3]	[0,0,0,0]	-8	hSpCas9	positive selection	4252249
100200848	100200871	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.23419034252401696	[3]	[0,2,0,0]	-3	hSpCas9	positive selection	4252260
100200876	100200899	12	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	0.3009594410271262	[2]	[2,1]	6	hSpCas9	positive selection	4254374
100200848	100200871	12	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.2330553669352622	[4]	[3,2]	-5	hSpCas9	positive selection	4254375
100200075	100200098	12	-	27661255	K562	viability	GACAGAGCGAGACTCCGGCAGGG	ACTR6	ENSG00000075089	-1.2812092441805292	[304,518]	[165,106]	-9	dCas9-KRAB	negative selection	5460789
100201012	100201035	12	-	27661255	K562	viability	GCTAAGTCAGGGCCGCGCGGGGG	ACTR6	ENSG00000075089	-0.008735708109548546	[635,673]	[586,461]	0	dCas9-KRAB	negative selection	5460790
100200876	100200899	12	+	27260156	BXPC3	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.646319031615442	[283]	[195,187,164,209]	-8	hSpCas9	negative selection	5526834
100200848	100200871	12	+	27260156	BXPC3	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.1001181290395108	[1763]	[819,956,743,917]	-9	hSpCas9	negative selection	5526835
100200876	100200899	12	+	27260156	A673	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.3741363130718459	[283]	[333,173,278,275]	-7	hSpCas9	negative selection	5648085
100200848	100200871	12	+	27260156	A673	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.6480737102610588	[1763]	[1440,1410,1221,1338]	-9	hSpCas9	negative selection	5648086
100200876	100200899	12	+	27260156	A375	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.8539559059059146	[283]	[92,320,81,247]	-8	hSpCas9	negative selection	5769336
100200848	100200871	12	+	27260156	A375	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.44297057325605	[1763]	[696,772,737,814]	-9	hSpCas9	negative selection	5769337
100200876	100200899	12	+	27260156	COLO741	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	0.23101593907629353	[283]	[438,401,435]	5	hSpCas9	negative selection	5890587
100200848	100200871	12	+	27260156	COLO741	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.9049131272245718	[1763]	[1204,1233,1171]	-9	hSpCas9	negative selection	5890588
100200876	100200899	12	+	27260156	CAL120	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.03758659308186807	[283]	[444,260,341]	0	hSpCas9	negative selection	6011838
100200848	100200871	12	+	27260156	CAL120	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.4077027177306634	[1763]	[667,1087,703]	-9	hSpCas9	negative selection	6011839
100200876	100200899	12	+	27260156	CADOES1	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.43664296571805117	[283]	[139,153,231,256]	-6	hSpCas9	negative selection	6133089
100200848	100200871	12	+	27260156	CADOES1	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.9347754326280028	[1763]	[764,983,838,844]	-9	hSpCas9	negative selection	6133090
100200876	100200899	12	+	27260156	EWS502	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.6378666195622092	[283]	[169,156,284,163]	-7	hSpCas9	negative selection	6254340
100200848	100200871	12	+	27260156	EWS502	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.8709467953660224	[1763]	[429,496,551,577]	-9	hSpCas9	negative selection	6254341
100200876	100200899	12	+	27260156	EW8	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.47235537377615466	[283]	[220,191,126,135]	-7	hSpCas9	negative selection	6375591
100200848	100200871	12	+	27260156	EW8	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.9102403000534091	[1763]	[677,837,716,805]	-9	hSpCas9	negative selection	6375592
100200876	100200899	12	+	27260156	CORL105	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.891258177300137	[283]	[205,246,135,120]	-9	hSpCas9	negative selection	6496842
100200848	100200871	12	+	27260156	CORL105	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.913595769647151	[1763]	[1028,980,1521,919]	-9	hSpCas9	negative selection	6496843
100200876	100200899	12	+	27260156	HS294T	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.8547387115628858	[283]	[36,27,50,143]	-8	hSpCas9	negative selection	6618093
100200848	100200871	12	+	27260156	HS294T	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.1782942799815959	[1763]	[167,246,249,604]	-9	hSpCas9	negative selection	6618094
100200876	100200899	12	+	27260156	HCC44	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.4199818915654071	[283]	[291,237,340,113]	-6	hSpCas9	negative selection	6739344
100200848	100200871	12	+	27260156	HCC44	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.7031527349785478	[1763]	[593,512,751,622]	-9	hSpCas9	negative selection	6739345
100200876	100200899	12	+	27260156	G402	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-1.7104307307281532	[283]	[103,111,53,150]	-9	hSpCas9	negative selection	6860595
100200848	100200871	12	+	27260156	G402	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.172523364174569	[1763]	[1074,780,859,1099]	-8	hSpCas9	negative selection	6860596
100200876	100200899	12	+	27260156	L33	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	0.5532821931986598	[283]	[471,155,293,345]	9	hSpCas9	negative selection	6981846
100200848	100200871	12	+	27260156	L33	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.2278624481841374	[1763]	[873,260,472,745]	-9	hSpCas9	negative selection	6981847
100200876	100200899	12	+	27260156	K562	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.8403522753673441	[283]	[40,117,195,191]	-7	hSpCas9	negative selection	7103097
100200848	100200871	12	+	27260156	K562	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.5186504334100475	[1763]	[423,448,1116,216]	-9	hSpCas9	negative selection	7103098
100200876	100200899	12	+	27260156	HT29	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.6841596406187874	[283]	[346,273,134,127]	-8	hSpCas9	negative selection	7224348
100200848	100200871	12	+	27260156	HT29	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.6330645532405255	[1763]	[724,778,678,598]	-9	hSpCas9	negative selection	7224349
100200876	100200899	12	+	27260156	MHHES1	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.7073981971112137	[283]	[170,254,226,141]	-8	hSpCas9	negative selection	7345599
100200848	100200871	12	+	27260156	MHHES1	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.0548764338626224	[1763]	[986,922,1042,870]	-9	hSpCas9	negative selection	7345600
100200876	100200899	12	+	27260156	MEWO	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.3617604853484805	[283]	[205,230,182]	-7	hSpCas9	negative selection	7466850
100200848	100200871	12	+	27260156	MEWO	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.9504705386456433	[1763]	[991,752,843]	-9	hSpCas9	negative selection	7466851
100200876	100200899	12	+	27260156	LNCAPCLONEFGC	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.5315755358564968	[283]	[249,107,150,201]	-7	hSpCas9	negative selection	7588101
100200848	100200871	12	+	27260156	LNCAPCLONEFGC	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.0270151953614945	[1763]	[672,685,1102,729]	-9	hSpCas9	negative selection	7588102
100200876	100200899	12	+	27260156	PANC0327	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.45711769242086964	[283]	[269,322,64,65]	-6	hSpCas9	negative selection	7709352
100200848	100200871	12	+	27260156	PANC0327	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.4248268310390804	[1763]	[774,619,357,591]	-9	hSpCas9	negative selection	7709353
100200876	100200899	12	+	27260156	NCIH2009	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-1.4989580221923826	[283]	[102,169,139]	-9	hSpCas9	negative selection	7830603
100200848	100200871	12	+	27260156	NCIH2009	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-2.3759038458721213	[1763]	[497,376,554]	-9	hSpCas9	negative selection	7830604
100200876	100200899	12	+	27260156	NCIH1373	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-1.3299296813181698	[283]	[146,157,138,14]	-8	hSpCas9	negative selection	7951854
100200848	100200871	12	+	27260156	NCIH1373	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-2.1494321720913674	[1763]	[519,351,357,152]	-9	hSpCas9	negative selection	7951855
100200876	100200899	12	+	27260156	PATU8902	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-2.153345861587896	[283]	[70,89,112,72]	-9	hSpCas9	negative selection	8073105
100200848	100200871	12	+	27260156	PATU8902	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.2970869152182323	[1763]	[1280,651,1336,577]	-8	hSpCas9	negative selection	8073106
100200876	100200899	12	+	27260156	PANC1	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-1.2463659889118852	[283]	[123,119,89,81]	-9	hSpCas9	negative selection	8194356
100200848	100200871	12	+	27260156	PANC1	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.4019870182580214	[1763]	[512,925,537,407]	-9	hSpCas9	negative selection	8194357
100200876	100200899	12	+	27260156	PANC0813	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-1.7111158942685587	[283]	[105,76,124,99]	-9	hSpCas9	negative selection	8315607
100200848	100200871	12	+	27260156	PANC0813	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.7942088280912258	[1763]	[755,530,482,630]	-9	hSpCas9	negative selection	8315608
100200876	100200899	12	+	27260156	RDES	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.8666237718168827	[283]	[200,167,173,159]	-9	hSpCas9	negative selection	8436858
100200848	100200871	12	+	27260156	RDES	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.1889964269545557	[1763]	[818,615,1102,1070]	-9	hSpCas9	negative selection	8436859
100200876	100200899	12	+	27260156	PC3	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	0.4004097025001479	[283]	[281,328,518,422]	8	hSpCas9	negative selection	8558109
100200848	100200871	12	+	27260156	PC3	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.2511796648433089	[1763]	[873,1491,2759,1406]	-5	hSpCas9	negative selection	8558110
100200876	100200899	12	+	27260156	PATU8988T	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.48807385513627854	[283]	[204,232,110,241]	-7	hSpCas9	negative selection	8679360
100200848	100200871	12	+	27260156	PATU8988T	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.025711128810749	[1763]	[802,704,1010,812]	-9	hSpCas9	negative selection	8679361
100200876	100200899	12	+	27260156	T47D	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.0720902364141176	[283]	[315,242,407,295]	-2	hSpCas9	negative selection	8800611
100200848	100200871	12	+	27260156	T47D	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.699472484990411	[1763]	[1258,1257,1378,1160]	-8	hSpCas9	negative selection	8800612
100200876	100200899	12	+	27260156	SU8686	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.9639815805758721	[283]	[124,160,110,184]	-8	hSpCas9	negative selection	8921862
100200848	100200871	12	+	27260156	SU8686	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-2.269210849513468	[1763]	[203,486,343,424]	-9	hSpCas9	negative selection	8921863
100200876	100200899	12	+	27260156	SKES1	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	0.12041733887431993	[283]	[479,294,286,201]	2	hSpCas9	negative selection	9043113
100200848	100200871	12	+	27260156	SKES1	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.635746627445869	[1763]	[1038,1168,1189,1112]	-8	hSpCas9	negative selection	9043114
100200876	100200899	12	+	27260156	TOV112D	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.18637416027146858	[283]	[224,328,255,207]	-4	hSpCas9	negative selection	9164364
100200848	100200871	12	+	27260156	TOV112D	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.7345838398888782	[1763]	[1309,1267,1218,534]	-9	hSpCas9	negative selection	9164365
100200876	100200899	12	+	27260156	TC71	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.23284674254328708	[283]	[176,280,269,312]	-6	hSpCas9	negative selection	9285615
100200848	100200871	12	+	27260156	TC71	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.5344165959934848	[1763]	[1427,1291,1255,1240]	-9	hSpCas9	negative selection	9285616
100200876	100200899	12	+	27260156	TC32	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.9590009792791011	[283]	[163,51,141,217]	-9	hSpCas9	negative selection	9406866
100200848	100200871	12	+	27260156	TC32	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.6263266723062062	[1763]	[914,694,1439,1432]	-8	hSpCas9	negative selection	9406867
100199179	100199202	12	+	27869803	HPAFII	viability after 27 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.042096969951555485	[320]	[224,112,NaN]	0	hSpCas9	negative selection	9544683
100199188	100199211	12	+	27869803	HPAFII	viability after 27 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	0.11853441145761101	[96]	[68,43,NaN]	0	hSpCas9	negative selection	9544684
100199179	100199202	12	+	27869803	HPAFII	viability after 15 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.30314310901061325	[320]	[360,228,NaN]	-3	hSpCas9	negative selection	9627132
100199188	100199211	12	+	27869803	HPAFII	viability after 15 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	0.7100547135304118	[96]	[209,145,NaN]	7	hSpCas9	negative selection	9627133
100199179	100199202	12	+	27869803	ASPC1	viability after 36 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.5338214110674196	[791]	[181,58,299]	-5	hSpCas9	negative selection	9709581
100199188	100199211	12	+	27869803	ASPC1	viability after 36 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	0.42934943152236554	[414]	[134,57,343]	4	hSpCas9	negative selection	9709582
100199179	100199202	12	+	27869803	PATU8988S	viability after 35 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	0.37359606330900386	[501]	[235,287,NaN]	4	hSpCas9	negative selection	9792030
100199188	100199211	12	+	27869803	PATU8988S	viability after 35 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	0.7499707165823859	[238]	[109,213,NaN]	7	hSpCas9	negative selection	9792031
100199179	100199202	12	+	27869803	PATU8988S	viability after 31 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	0.37262844437058273	[501]	[263,252,NaN]	4	hSpCas9	negative selection	9874479
100199188	100199211	12	+	27869803	PATU8988S	viability after 31 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	0.45847388204127515	[238]	[82,191,NaN]	5	hSpCas9	negative selection	9874480
100199179	100199202	12	+	27869803	HPAFII	viability after 35 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.7146387583459499	[320]	[146,44,NaN]	-4	hSpCas9	negative selection	9956928
100199188	100199211	12	+	27869803	HPAFII	viability after 35 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	0.10513844557677898	[96]	[41,64,NaN]	0	hSpCas9	negative selection	9956929
100199179	100199202	12	+	27869803	HPAFII	viability after 31 days	ACGGTTATGAATGCTTGGGAGGG	ACTR6	ENSG00000075089	-0.8843546322887414	[320]	[121,70,NaN]	-5	hSpCas9	negative selection	10039377
100199188	100199211	12	+	27869803	HPAFII	viability after 31 days	AATGCTTGGGAGGGCTGCACCGG	ACTR6	ENSG00000075089	0.05327249627237163	[96]	[44,68,NaN]	0	hSpCas9	negative selection	10039378
100200848	100200871	12	+	28162770	P31FUJ	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.8177647051355348	[140]	[46]	-8	hSpCas9	negative selection	10106562
100200876	100200899	12	+	28162770	P31FUJ	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.30800854860355237	[314]	[298]	-3	hSpCas9	negative selection	10106563
100200848	100200871	12	+	28162770	TF1	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	NaN	[NaN]	[3]	1	hSpCas9	negative selection	10275928
100200876	100200899	12	+	28162770	TF1	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	NaN	[NaN]	[276]	1	hSpCas9	negative selection	10275929
100200848	100200871	12	+	28162770	SKM1	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-2.1887840286936284	[48]	[18]	-8	hSpCas9	negative selection	10445294
100200876	100200899	12	+	28162770	SKM1	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.9127671619451878	[81]	[76]	-6	hSpCas9	negative selection	10445295
100200848	100200871	12	+	28162770	SKM1	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-2.1887840286936284	[48]	[18]	-8	hSpCas9	negative selection	10614660
100200876	100200899	12	+	28162770	SKM1	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.9127671619451878	[81]	[76]	-6	hSpCas9	negative selection	10614661
100200848	100200871	12	+	28162770	PL21	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.6350495157650096	[156]	[21]	-8	hSpCas9	negative selection	10784026
100200876	100200899	12	+	28162770	PL21	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	1.8154757642539952	[281]	[431]	9	hSpCas9	negative selection	10784027
100200848	100200871	12	+	28162770	P31FUJ	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.8177647051355348	[140]	[46]	-8	hSpCas9	negative selection	10953392
100200876	100200899	12	+	28162770	P31FUJ	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.30800854860355237	[314]	[298]	-3	hSpCas9	negative selection	10953393
100200848	100200871	12	+	28162770	OCIAML5	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-0.3524955613734855	[57]	[81]	-3	hSpCas9	negative selection	11122758
100200876	100200899	12	+	28162770	OCIAML5	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	0.2706159489108316	[168]	[367]	2	hSpCas9	negative selection	11122759
100200848	100200871	12	+	28162770	EOL1	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-3.0581742369976297	[331]	[20]	-9	hSpCas9	negative selection	11292124
100200876	100200899	12	+	28162770	EOL1	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.5440906111833897	[392]	[141]	-4	hSpCas9	negative selection	11292125
100200848	100200871	12	+	28162770	MOLM13	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-2.5093905419553377	[251]	[31]	-8	hSpCas9	negative selection	11461490
100200876	100200899	12	+	28162770	MOLM13	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.38837514099397163	[524]	[289]	-2	hSpCas9	negative selection	11461491
100200848	100200871	12	+	28162770	HEL	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-3.0515223112116105	[232]	[17]	-8	hSpCas9	negative selection	11630856
100200876	100200899	12	+	28162770	HEL	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.5508651659114661	[429]	[187]	-4	hSpCas9	negative selection	11630857
100200848	100200871	12	+	28162770	MV411	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.8018059682370737	[148]	[35]	-8	hSpCas9	negative selection	11800222
100200876	100200899	12	+	28162770	MV411	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-1.7008474126730695	[273]	[70]	-8	hSpCas9	negative selection	11800223
100200848	100200871	12	+	28162770	MONOMAC1	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-2.2844996883098934	[135]	[31]	-9	hSpCas9	negative selection	11969588
100200876	100200899	12	+	28162770	MONOMAC1	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-1.8352975739407589	[192]	[61]	-8	hSpCas9	negative selection	11969589
100200848	100200871	12	+	28162770	OCIAML2	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-3.470629825242161	[35]	[17]	-9	hSpCas9	negative selection	12138954
100200876	100200899	12	+	28162770	OCIAML2	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.3775204208506798	[44]	[191]	-3	hSpCas9	negative selection	12138955
100200848	100200871	12	+	28162770	OCIAML3	viability	TGAGATGACGACCTTAGTGCTGG	ACTR6	ENSG00000075089	-1.805511745517875	[43]	[37]	-8	hSpCas9	negative selection	12308320
100200876	100200899	12	+	28162770	OCIAML3	viability	GGAGCTTACAACGCCAAAATCGG	ACTR6	ENSG00000075089	-0.17079620959961916	[87]	[235]	-1	hSpCas9	negative selection	12308321