Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:577
• Symbol:ADGRB3
• Description:adhesion G protein-coupled receptor B3

DataSource: http://genomecrispr.dkfz.de/#!/results/ADGRB3

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
69192469	69192492	6	-	25494202	A375	resistance to PLX-4720 (puromycin)	GTCTGTGAGGGTGTTACCAAAGG	ADGRB3	ENSG00000135298	-0.9223729288377451	[989,139]	[112,12]	-5	dCas9-VP64	positive selection	2384780
69255986	69256009	6	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGTTTGTCAAAGATCAGAGAG	ADGRB3	ENSG00000135298	1.4991791668463312	[489,99]	[158,205]	5	dCas9-VP64	positive selection	2399007
69052031	69052054	6	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCGCCCACCACCACGCCGGG	ADGRB3	ENSG00000135298	1.906510521561382	[74,11]	[56,10]	6	dCas9-VP64	positive selection	2400630
69002256	69002279	6	+	25494202	A375	resistance to PLX-4720 (puromycin)	GTCGCCAGGCTGGAGTACAGTGG	ADGRB3	ENSG00000135298	0.42704561705979716	[5,14]	[1,3]	2	dCas9-VP64	positive selection	2412489
68670639	68670662	6	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCATGCTGTTTTGGTGACTATAG	ADGRB3	ENSG00000135298	1.0480995924872216	[118,451]	[10,260]	4	dCas9-VP64	positive selection	2417716
69348545	69348568	6	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCCAGCTACTCATGAGGCTGTGG	ADGRB3	ENSG00000135298	-2.630283297450045	[595,43]	[15,4]	-9	dCas9-VP64	positive selection	2425440
68911139	68911162	6	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCATCATTCTCAGCAAACTATAG	ADGRB3	ENSG00000135298	-1.416334702545214	[45,532]	[4,43]	-7	dCas9-VP64	positive selection	2427626
68635570	68635593	6	-	25494202	A375	resistance to PLX-4720 (puromycin)	GCGCTGAGACGAGAAGTGACCGG	ADGRB3	ENSG00000135298	3.4547330423514904	[150,81]	[33,547]	9	dCas9-VP64	positive selection	2428318
68635549	68635572	6	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGCGGCGGCGGCGGCTGCTATGG	ADGRB3	ENSG00000135298	-0.9074391176586036	[36,5]	[1,2]	-5	dCas9-VP64	positive selection	2428319
68635597	68635620	6	+	25494202	A375	resistance to PLX-4720 (puromycin)	TTTGCTTCTTGGTTTGTTGGGGG	ADGRB3	ENSG00000135298	-1.8186343243228067	[390,56]	[20,4]	-8	dCas9-VP64	positive selection	2428320
69088513	69088536	6	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCAGGTGCCACCACGCCTGG	ADGRB3	ENSG00000135298	-0.4083852587886121	[270,115]	[25,36]	-2	dCas9-VP64	positive selection	2458729
68646370	68646393	6	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGGAGGCTGAGGCAGGAGAACAG	ADGRB3	ENSG00000135298	1.7244712313844854	[32,17]	[27,7]	6	dCas9-VP64	positive selection	2468542
68682983	68683006	6	-	25494202	A375	resistance to PLX-4720 (puromycin)	CAAGACCAGCCTCGCCAACACAG	ADGRB3	ENSG00000135298	0.26554877243276964	[151,147]	[20,58]	1	dCas9-VP64	positive selection	2476665
69192469	69192492	6	-	25494202	A375	resistance to PLX-4720 (zeocin)	GTCTGTGAGGGTGTTACCAAAGG	ADGRB3	ENSG00000135298	-0.4431641880095602	[225,193]	[45,53]	-4	dCas9-VP64	positive selection	2480035
69255986	69256009	6	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGTTTGTCAAAGATCAGAGAG	ADGRB3	ENSG00000135298	0.7436378765259763	[241,330]	[65,240]	5	dCas9-VP64	positive selection	2494262
69052031	69052054	6	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCGCCCACCACCACGCCGGG	ADGRB3	ENSG00000135298	1.1664475786686166	[321,97]	[88,216]	7	dCas9-VP64	positive selection	2495885
69002256	69002279	6	+	25494202	A375	resistance to PLX-4720 (zeocin)	GTCGCCAGGCTGGAGTACAGTGG	ADGRB3	ENSG00000135298	0.7866946329190116	[53,86]	[29,47]	5	dCas9-VP64	positive selection	2507744
68670639	68670662	6	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCATGCTGTTTTGGTGACTATAG	ADGRB3	ENSG00000135298	0.32664799356599117	[40,68]	[18,24]	2	dCas9-VP64	positive selection	2512971
69348545	69348568	6	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCCAGCTACTCATGAGGCTGTGG	ADGRB3	ENSG00000135298	-0.13308533926697091	[158,117]	[51,29]	-1	dCas9-VP64	positive selection	2520695
68911139	68911162	6	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCATCATTCTCAGCAAACTATAG	ADGRB3	ENSG00000135298	0.2393242830696749	[123,274]	[75,75]	2	dCas9-VP64	positive selection	2522881
68635570	68635593	6	-	25494202	A375	resistance to PLX-4720 (zeocin)	GCGCTGAGACGAGAAGTGACCGG	ADGRB3	ENSG00000135298	0.00354303530172706	[102,81]	[37,22]	0	dCas9-VP64	positive selection	2523573
68635549	68635572	6	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGCGGCGGCGGCGGCTGCTATGG	ADGRB3	ENSG00000135298	1.1007906621261678	[70,10]	[16,40]	7	dCas9-VP64	positive selection	2523574
68635597	68635620	6	+	25494202	A375	resistance to PLX-4720 (zeocin)	TTTGCTTCTTGGTTTGTTGGGGG	ADGRB3	ENSG00000135298	-0.49158833111094624	[106,8]	[13,12]	-5	dCas9-VP64	positive selection	2523575
69088513	69088536	6	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCAGGTGCCACCACGCCTGG	ADGRB3	ENSG00000135298	-0.7887530655441356	[186,58]	[27,18]	-7	dCas9-VP64	positive selection	2553984
68646370	68646393	6	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGGAGGCTGAGGCAGGAGAACAG	ADGRB3	ENSG00000135298	-0.1093774260535414	[64,117]	[17,35]	-1	dCas9-VP64	positive selection	2563797
68682983	68683006	6	-	25494202	A375	resistance to PLX-4720 (zeocin)	CAAGACCAGCCTCGCCAACACAG	ADGRB3	ENSG00000135298	3.0708898277967998	[136,69]	[553,38]	9	dCas9-VP64	positive selection	2571920
68639336	68639359	6	+	26780180	HT29	viability (Avana library 4 designs)	CCCCTGAATGAGCAGACAGAGGG	ADGRB3	ENSG00000135298	1.36514196764124	[]	[]	5	hSpCas9	negative selection	3405082
69048212	69048235	6	-	26780180	HT29	viability (Avana library 4 designs)	GTTGATGTCTGTTAGAACAGAGG	ADGRB3	ENSG00000135298	-0.138541061032389	[]	[]	-2	hSpCas9	negative selection	3405083
68974779	68974802	6	-	26780180	HT29	viability (Avana library 4 designs)	TCGACATCAGATAATCCTCAGGG	ADGRB3	ENSG00000135298	-0.263174574513777	[]	[]	-4	hSpCas9	negative selection	3405084
68993769	68993792	6	+	26780180	HT29	viability (Avana library 4 designs)	TTAAAGAGCACCTTGCTAAGGGG	ADGRB3	ENSG00000135298	0.535112714046669	[]	[]	2	hSpCas9	negative selection	3405085
69048212	69048235	6	-	26780180	A375	viability (Avana lentiCRISPRv2)	GTTGATGTCTGTTAGAACAGAGG	ADGRB3	ENSG00000135298	3.25708370108418	[]	[]	5	hSpCas9	negative selection	3476924
68993769	68993792	6	+	26780180	A375	viability (Avana lentiCRISPRv2)	TTAAAGAGCACCTTGCTAAGGGG	ADGRB3	ENSG00000135298	0.831598463365168	[]	[]	1	hSpCas9	negative selection	3476925
68639336	68639359	6	+	26780180	A375	viability (Avana lentiCRISPRv2)	CCCCTGAATGAGCAGACAGAGGG	ADGRB3	ENSG00000135298	2.53579778949676	[]	[]	4	hSpCas9	negative selection	3476926
68974779	68974802	6	-	26780180	A375	viability (Avana lentiCRISPRv2)	TCGACATCAGATAATCCTCAGGG	ADGRB3	ENSG00000135298	-8.57409544182098	[]	[]	-7	hSpCas9	negative selection	3476927
68639386	68639409	6	+	26780180	A375	viability (Avana lentiCRISPRv2)	CCAAGTCTGCAATCTTACCAGGG	ADGRB3	ENSG00000135298	-5.36853224733714	[]	[]	-5	hSpCas9	negative selection	3476928
68936669	68936692	6	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCTAACACTACCTGGACAGAGGG	ADGRB3	ENSG00000135298	0.880430902009832	[]	[]	1	hSpCas9	negative selection	3476929
69048212	69048235	6	-	26780180	A375	viability (Avana lentiGuide)	GTTGATGTCTGTTAGAACAGAGG	ADGRB3	ENSG00000135298	-2.86032881659072	[]	[]	-5	hSpCas9	negative selection	3585583
68993769	68993792	6	+	26780180	A375	viability (Avana lentiGuide)	TTAAAGAGCACCTTGCTAAGGGG	ADGRB3	ENSG00000135298	-3.78481534463603	[]	[]	-6	hSpCas9	negative selection	3585584
68639336	68639359	6	+	26780180	A375	viability (Avana lentiGuide)	CCCCTGAATGAGCAGACAGAGGG	ADGRB3	ENSG00000135298	2.48956189059438	[]	[]	2	hSpCas9	negative selection	3585585
68974779	68974802	6	-	26780180	A375	viability (Avana lentiGuide)	TCGACATCAGATAATCCTCAGGG	ADGRB3	ENSG00000135298	-0.0659946985059948	[]	[]	0	hSpCas9	negative selection	3585586
68639386	68639409	6	+	26780180	A375	viability (Avana lentiGuide)	CCAAGTCTGCAATCTTACCAGGG	ADGRB3	ENSG00000135298	3.44712177898819	[]	[]	3	hSpCas9	negative selection	3585587
68936669	68936692	6	-	26780180	A375	viability (Avana lentiGuide)	GCTAACACTACCTGGACAGAGGG	ADGRB3	ENSG00000135298	-2.17342411125839	[]	[]	-4	hSpCas9	negative selection	3585588
69048212	69048235	6	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTTGATGTCTGTTAGAACAGAGG	ADGRB3	ENSG00000135298	0.052851148577696294	[6]	[7,6]	1	hSpCas9	positive selection	3694242
68993769	68993792	6	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTAAAGAGCACCTTGCTAAGGGG	ADGRB3	ENSG00000135298	-0.07215794634557357	[5]	[5,4]	-1	hSpCas9	positive selection	3694243
68639336	68639359	6	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCCCTGAATGAGCAGACAGAGGG	ADGRB3	ENSG00000135298	-0.06397907145478265	[3]	[3,3]	-1	hSpCas9	positive selection	3694244
68974779	68974802	6	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TCGACATCAGATAATCCTCAGGG	ADGRB3	ENSG00000135298	-0.5621016711851561	[5]	[4,2]	-7	hSpCas9	positive selection	3694245
68639386	68639409	6	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCAAGTCTGCAATCTTACCAGGG	ADGRB3	ENSG00000135298	-0.41428303097121266	[4]	[3,2]	-6	hSpCas9	positive selection	3694246
68936669	68936692	6	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTAACACTACCTGGACAGAGGG	ADGRB3	ENSG00000135298	-0.08403339540832594	[4]	[4,4]	-1	hSpCas9	positive selection	3694247
69048212	69048235	6	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTTGATGTCTGTTAGAACAGAGG	ADGRB3	ENSG00000135298	0.27543571625593277	[6]	[6,6]	7	hSpCas9	positive selection	3802849
68993769	68993792	6	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTAAAGAGCACCTTGCTAAGGGG	ADGRB3	ENSG00000135298	-0.05637208899445374	[5]	[5,3]	-1	hSpCas9	positive selection	3802850
68639336	68639359	6	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCCCTGAATGAGCAGACAGAGGG	ADGRB3	ENSG00000135298	-0.7004268491740309	[4]	[1,1]	-7	hSpCas9	positive selection	3802851
68974779	68974802	6	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TCGACATCAGATAATCCTCAGGG	ADGRB3	ENSG00000135298	0.2173641741685034	[5]	[6,5]	5	hSpCas9	positive selection	3802852
68639386	68639409	6	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCAAGTCTGCAATCTTACCAGGG	ADGRB3	ENSG00000135298	0.035647893475299765	[5]	[5,3]	0	hSpCas9	positive selection	3802853
68936669	68936692	6	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTAACACTACCTGGACAGAGGG	ADGRB3	ENSG00000135298	0.36505691719259414	[5]	[5,6]	9	hSpCas9	positive selection	3802854
68639385	68639408	6	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.5391758199720296	[4]	[4,4]	9	hSpCas9	positive selection	4168499
68930601	68930624	6	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	-0.38235981263722046	[2]	[0,0]	-7	hSpCas9	positive selection	4168510
68930600	68930623	6	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTTTTTTCATGAACAGATCGAGG	ADGRB3	ENSG00000135298	-0.23124219310326571	[3]	[2,1]	-5	hSpCas9	positive selection	4168522
68639411	68639434	6	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCCAAGCGACCACCCAAAGAAGG	ADGRB3	ENSG00000135298	-0.11853349950685066	[2]	[1,0]	-3	hSpCas9	positive selection	4168533
68639385	68639408	6	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.18984010809004365	[3]	[3,3,2,0]	1	hSpCas9	positive selection	4232521
68930601	68930624	6	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.6226362112780329	[2]	[2,3,1,0]	4	hSpCas9	positive selection	4232532
68930600	68930623	6	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTTTTTTCATGAACAGATCGAGG	ADGRB3	ENSG00000135298	0.4521084005875162	[1]	[0,2,0,0]	3	hSpCas9	positive selection	4232544
68639411	68639434	6	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCCAAGCGACCACCCAAAGAAGG	ADGRB3	ENSG00000135298	-0.1768614253826486	[2]	[1,0,0,0]	-3	hSpCas9	positive selection	4232555
68943821	68943844	6	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.20232834961190152	[3]	[3,2]	4	hSpCas9	positive selection	4257820
68639385	68639408	6	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	-0.08862697958818123	[3]	[2,1]	-2	hSpCas9	positive selection	4257821
68639153	68639176	6	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.33731847239874935	[3]	[4,3]	6	hSpCas9	positive selection	4257822
68930601	68930624	6	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.5380513384495078	[2]	[2,3]	9	hSpCas9	positive selection	4322104
68943910	68943933	6	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.45938104482765774	[5]	[5,5]	8	hSpCas9	positive selection	4322105
68930638	68930661	6	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.23736695735820426	[2]	[2,2]	5	hSpCas9	positive selection	4322106
68943821	68943844	6	+	27260156	BXPC3	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.11836769650391399	[701]	[754,691,859,898]	2	hSpCas9	negative selection	5530280
68639385	68639408	6	+	27260156	BXPC3	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.3039256109225368	[552]	[737,597,739,787]	6	hSpCas9	negative selection	5530281
68639153	68639176	6	+	27260156	BXPC3	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.217569343412506	[916]	[985,1069,1074,1367]	5	hSpCas9	negative selection	5530282
68930601	68930624	6	+	27260156	BXPC3	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.15365277880941353	[326]	[317,367,350,503]	3	hSpCas9	negative selection	5594564
68943910	68943933	6	+	27260156	BXPC3	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.26119543801394274	[2679]	[2910,3246,3428,3952]	6	hSpCas9	negative selection	5594565
68930638	68930661	6	+	27260156	BXPC3	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.017427380165081163	[392]	[300,389,471,480]	0	hSpCas9	negative selection	5594566
68943821	68943844	6	+	27260156	A673	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.1762800654957163	[701]	[1056,876,995,887]	4	hSpCas9	negative selection	5651531
68639385	68639408	6	+	27260156	A673	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.42473059721376505	[552]	[1022,774,872,911]	8	hSpCas9	negative selection	5651532
68639153	68639176	6	+	27260156	A673	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.1830629695447613	[916]	[1209,1176,1399,1203]	4	hSpCas9	negative selection	5651533
68930601	68930624	6	+	27260156	A673	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.18711946105547161	[326]	[419,400,510,452]	4	hSpCas9	negative selection	5715815
68943910	68943933	6	+	27260156	A673	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.1298591379822822	[2679]	[3735,3472,3308,3590]	3	hSpCas9	negative selection	5715816
68930638	68930661	6	+	27260156	A673	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.042885292256421126	[392]	[514,343,483,499]	-1	hSpCas9	negative selection	5715817
68943821	68943844	6	+	27260156	A375	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.553486261577899	[701]	[1294,1348,1068,1125]	7	hSpCas9	negative selection	5772782
68639385	68639408	6	+	27260156	A375	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.38964957944483614	[552]	[974,968,780,692]	5	hSpCas9	negative selection	5772783
68639153	68639176	6	+	27260156	A375	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.12467253132550427	[916]	[1451,1535,927,842]	1	hSpCas9	negative selection	5772784
68930601	68930624	6	+	27260156	A375	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.40378642742592546	[326]	[609,487,279,624]	6	hSpCas9	negative selection	5837066
68943910	68943933	6	+	27260156	A375	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.36115276491872406	[2679]	[3313,4407,4405,3990]	5	hSpCas9	negative selection	5837067
68930638	68930661	6	+	27260156	A375	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.1678149590258312	[392]	[676,484,550,362]	2	hSpCas9	negative selection	5837068
68943821	68943844	6	+	27260156	COLO741	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	-0.019786553347559188	[701]	[797,919,923]	0	hSpCas9	negative selection	5894033
68639385	68639408	6	+	27260156	COLO741	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.3733015825259457	[552]	[1107,978,689]	7	hSpCas9	negative selection	5894034
68639153	68639176	6	+	27260156	COLO741	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.1628959036368559	[916]	[1615,1205,1147]	3	hSpCas9	negative selection	5894035
68930601	68930624	6	+	27260156	COLO741	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.20238132663049674	[326]	[427,628,386]	4	hSpCas9	negative selection	5958317
68943910	68943933	6	+	27260156	COLO741	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.2474320033197399	[2679]	[4704,3948,3618]	5	hSpCas9	negative selection	5958318
68930638	68930661	6	+	27260156	COLO741	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.12312335973473892	[392]	[470,506,408]	-3	hSpCas9	negative selection	5958319
68943821	68943844	6	+	27260156	CAL120	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.724199504697081	[701]	[1448,1179,1695]	9	hSpCas9	negative selection	6015284
68639385	68639408	6	+	27260156	CAL120	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.5618092352550347	[552]	[1327,866,900]	8	hSpCas9	negative selection	6015285
68639153	68639176	6	+	27260156	CAL120	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.22371699760122	[916]	[1542,1172,1312]	3	hSpCas9	negative selection	6015286
68930601	68930624	6	+	27260156	CAL120	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.3411721142306854	[326]	[641,505,418]	5	hSpCas9	negative selection	6079568
68943910	68943933	6	+	27260156	CAL120	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.4749767825703972	[2679]	[5051,4194,4717]	7	hSpCas9	negative selection	6079569
68930638	68930661	6	+	27260156	CAL120	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.22218445666820574	[392]	[538,348,813]	3	hSpCas9	negative selection	6079570
68943821	68943844	6	+	27260156	CADOES1	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.325926009570527	[701]	[782,764,843,883]	5	hSpCas9	negative selection	6136535
68639385	68639408	6	+	27260156	CADOES1	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.7993477063639707	[552]	[706,814,1381,667]	9	hSpCas9	negative selection	6136536
68639153	68639176	6	+	27260156	CADOES1	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.3273863333378412	[916]	[786,941,1171,1391]	5	hSpCas9	negative selection	6136537
68930601	68930624	6	+	27260156	CADOES1	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.26478665619360814	[326]	[458,222,312,469]	4	hSpCas9	negative selection	6200819
68943910	68943933	6	+	27260156	CADOES1	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.34669455867182597	[2679]	[3015,3303,3271,3083]	6	hSpCas9	negative selection	6200820
68930638	68930661	6	+	27260156	CADOES1	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.305782942566948	[392]	[433,488,466,415]	5	hSpCas9	negative selection	6200821
68943821	68943844	6	+	27260156	EWS502	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.21877815488351138	[701]	[714,777,967,1031]	4	hSpCas9	negative selection	6257786
68639385	68639408	6	+	27260156	EWS502	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.17614491470927549	[552]	[526,580,664,908]	3	hSpCas9	negative selection	6257787
68639153	68639176	6	+	27260156	EWS502	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.15458111061255575	[916]	[989,990,1109,1256]	2	hSpCas9	negative selection	6257788
68930601	68930624	6	+	27260156	EWS502	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.1107135273989483	[326]	[248,405,316,547]	2	hSpCas9	negative selection	6322070
68943910	68943933	6	+	27260156	EWS502	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.16283629038819525	[2679]	[3112,2872,3340,3410]	3	hSpCas9	negative selection	6322071
68930638	68930661	6	+	27260156	EWS502	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.10977635919094275	[392]	[285,326,566,377]	-2	hSpCas9	negative selection	6322072
68943821	68943844	6	+	27260156	EW8	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.10546665220373219	[701]	[659,628,539,634]	2	hSpCas9	negative selection	6379037
68639385	68639408	6	+	27260156	EW8	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.21343789207577932	[552]	[505,538,564,457]	4	hSpCas9	negative selection	6379038
68639153	68639176	6	+	27260156	EW8	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.12526852704750036	[916]	[713,671,791,1052]	2	hSpCas9	negative selection	6379039
68930601	68930624	6	+	27260156	EW8	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.10858927718729616	[326]	[330,334,180,317]	2	hSpCas9	negative selection	6443321
68943910	68943933	6	+	27260156	EW8	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.20545514807408605	[2679]	[2761,2574,2267,2473]	4	hSpCas9	negative selection	6443322
68930638	68930661	6	+	27260156	EW8	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.020356327021892162	[392]	[332,396,369,184]	0	hSpCas9	negative selection	6443323
68943821	68943844	6	+	27260156	CORL105	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.3727612656932624	[701]	[939,934,1155,1236]	7	hSpCas9	negative selection	6500288
68639385	68639408	6	+	27260156	CORL105	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.43204171703687355	[552]	[778,1000,924,790]	7	hSpCas9	negative selection	6500289
68639153	68639176	6	+	27260156	CORL105	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.45772622599850254	[916]	[1570,1443,1442,1437]	8	hSpCas9	negative selection	6500290
68930601	68930624	6	+	27260156	CORL105	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.20887383448977542	[326]	[400,357,583,448]	4	hSpCas9	negative selection	6564572
68943910	68943933	6	+	27260156	CORL105	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.37141707454200956	[2679]	[3678,4284,4520,3803]	7	hSpCas9	negative selection	6564573
68930638	68930661	6	+	27260156	CORL105	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.13418453182730966	[392]	[562,439,568,460]	2	hSpCas9	negative selection	6564574
68943821	68943844	6	+	27260156	HS294T	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.247992188857034	[701]	[230,286,324,481]	3	hSpCas9	negative selection	6621539
68639385	68639408	6	+	27260156	HS294T	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.7358302171496014	[552]	[371,357,332,358]	8	hSpCas9	negative selection	6621540
68639153	68639176	6	+	27260156	HS294T	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.5884080606445744	[916]	[466,544,594,528]	7	hSpCas9	negative selection	6621541
68930601	68930624	6	+	27260156	HS294T	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	-0.1943456850051153	[326]	[135,87,89,128]	-3	hSpCas9	negative selection	6685823
68943910	68943933	6	+	27260156	HS294T	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.24439969597785938	[2679]	[1159,1195,1107,1493]	3	hSpCas9	negative selection	6685824
68930638	68930661	6	+	27260156	HS294T	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.1289010340419121	[392]	[92,154,153,160]	-2	hSpCas9	negative selection	6685825
68943821	68943844	6	+	27260156	HCC44	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.5418839181722854	[701]	[1188,1011,1428,1057]	8	hSpCas9	negative selection	6742790
68639385	68639408	6	+	27260156	HCC44	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.5112082831850625	[552]	[832,743,1387,700]	8	hSpCas9	negative selection	6742791
68639153	68639176	6	+	27260156	HCC44	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	-0.03293804999510852	[916]	[1056,874,1130,1026]	0	hSpCas9	negative selection	6742792
68930601	68930624	6	+	27260156	HCC44	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.2957580891350341	[326]	[506,292,650,423]	5	hSpCas9	negative selection	6807074
68943910	68943933	6	+	27260156	HCC44	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.4021578280713327	[2679]	[4987,3001,4658,3695]	6	hSpCas9	negative selection	6807075
68930638	68930661	6	+	27260156	HCC44	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.47953304884342446	[392]	[296,252,559,214]	-6	hSpCas9	negative selection	6807076
68943821	68943844	6	+	27260156	G402	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.2954237454940949	[701]	[881,946,1218,1118]	3	hSpCas9	negative selection	6864041
68639385	68639408	6	+	27260156	G402	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.39253279642326566	[552]	[1078,584,1210,684]	5	hSpCas9	negative selection	6864042
68639153	68639176	6	+	27260156	G402	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.6021984157125227	[916]	[1536,1244,1410,2504]	7	hSpCas9	negative selection	6864043
68930601	68930624	6	+	27260156	G402	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.7212324853449115	[326]	[259,828,555,922]	8	hSpCas9	negative selection	6928325
68943910	68943933	6	+	27260156	G402	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.7588012245466249	[2679]	[6945,4929,5277,5145]	8	hSpCas9	negative selection	6928326
68930638	68930661	6	+	27260156	G402	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.8091312883391035	[392]	[1120,631,896,740]	8	hSpCas9	negative selection	6928327
68943821	68943844	6	+	27260156	L33	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	-0.3186293000568012	[701]	[652,196,336,578]	-6	hSpCas9	negative selection	6985292
68639385	68639408	6	+	27260156	L33	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.38390977176039687	[552]	[713,295,456,722]	7	hSpCas9	negative selection	6985293
68639153	68639176	6	+	27260156	L33	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.2909674520820157	[916]	[1263,387,713,1136]	6	hSpCas9	negative selection	6985294
68930601	68930624	6	+	27260156	L33	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	-0.297107220328536	[326]	[168,142,189,246]	-6	hSpCas9	negative selection	7049576
68943910	68943933	6	+	27260156	L33	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.06270153677124535	[2679]	[2793,1087,1928,2679]	1	hSpCas9	negative selection	7049577
68930638	68930661	6	+	27260156	L33	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.514472270997125	[392]	[253,119,184,259]	-8	hSpCas9	negative selection	7049578
68943821	68943844	6	+	27260156	K562	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.7496683171401766	[701]	[1166,1301,1148,638]	8	hSpCas9	negative selection	7106543
68639385	68639408	6	+	27260156	K562	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.473944143206504	[552]	[758,859,483,640]	6	hSpCas9	negative selection	7106544
68639153	68639176	6	+	27260156	K562	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.1846603691075771	[916]	[1118,651,961,959]	2	hSpCas9	negative selection	7106545
68930601	68930624	6	+	27260156	K562	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	-0.05100824020912864	[326]	[418,291,203,222]	0	hSpCas9	negative selection	7170827
68943910	68943933	6	+	27260156	K562	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.11480050209873038	[2679]	[3065,2395,2029,2801]	1	hSpCas9	negative selection	7170828
68930638	68930661	6	+	27260156	K562	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.3375971036670376	[392]	[551,520,389,324]	4	hSpCas9	negative selection	7170829
68943821	68943844	6	+	27260156	HT29	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.3764103091149058	[701]	[989,1246,1010,1169]	7	hSpCas9	negative selection	7227794
68639385	68639408	6	+	27260156	HT29	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.13226575886586703	[552]	[708,620,847,749]	2	hSpCas9	negative selection	7227795
68639153	68639176	6	+	27260156	HT29	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	-0.011966482706459836	[916]	[1149,1276,1149,882]	0	hSpCas9	negative selection	7227796
68930601	68930624	6	+	27260156	HT29	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.1160181066787026	[326]	[425,613,350,353]	2	hSpCas9	negative selection	7292078
68943910	68943933	6	+	27260156	HT29	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.19076231024261592	[2679]	[4454,3933,3410,3187]	4	hSpCas9	negative selection	7292079
68930638	68930661	6	+	27260156	HT29	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.01614282840786896	[392]	[551,558,452,350]	0	hSpCas9	negative selection	7292080
68943821	68943844	6	+	27260156	MHHES1	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.1279530260872347	[701]	[1197,889,658,755]	2	hSpCas9	negative selection	7349045
68639385	68639408	6	+	27260156	MHHES1	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.38887463100334296	[552]	[957,762,741,795]	7	hSpCas9	negative selection	7349046
68639153	68639176	6	+	27260156	MHHES1	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.018064535675069604	[916]	[1178,1202,958,886]	0	hSpCas9	negative selection	7349047
68930601	68930624	6	+	27260156	MHHES1	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.27359054049866294	[326]	[509,487,288,484]	5	hSpCas9	negative selection	7413329
68943910	68943933	6	+	27260156	MHHES1	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.2523394285384257	[2679]	[4279,4436,3166,2773]	4	hSpCas9	negative selection	7413330
68930638	68930661	6	+	27260156	MHHES1	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.3337094682267027	[392]	[559,421,526,668]	6	hSpCas9	negative selection	7413331
68943821	68943844	6	+	27260156	MEWO	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.08547406734221641	[701]	[778,760,565]	2	hSpCas9	negative selection	7470296
68639385	68639408	6	+	27260156	MEWO	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	-0.05182070226254823	[552]	[610,478,428]	-1	hSpCas9	negative selection	7470297
68639153	68639176	6	+	27260156	MEWO	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.13504881957346415	[916]	[1314,803,779]	3	hSpCas9	negative selection	7470298
68930601	68930624	6	+	27260156	MEWO	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.28676989957233	[326]	[392,242,487]	6	hSpCas9	negative selection	7534580
68943910	68943933	6	+	27260156	MEWO	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.20706082147004956	[2679]	[3399,2717,2662]	4	hSpCas9	negative selection	7534581
68930638	68930661	6	+	27260156	MEWO	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.35631875323414836	[392]	[360,259,254]	-6	hSpCas9	negative selection	7534582
68943821	68943844	6	+	27260156	LNCAPCLONEFGC	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.4424272754365235	[701]	[872,833,885,867]	7	hSpCas9	negative selection	7591547
68639385	68639408	6	+	27260156	LNCAPCLONEFGC	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.3597957247181274	[552]	[637,549,749,654]	5	hSpCas9	negative selection	7591548
68639153	68639176	6	+	27260156	LNCAPCLONEFGC	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.3804521673487725	[916]	[1206,880,1334,949]	6	hSpCas9	negative selection	7591549
68930601	68930624	6	+	27260156	LNCAPCLONEFGC	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.40209707240840115	[326]	[340,311,642,312]	6	hSpCas9	negative selection	7655831
68943910	68943933	6	+	27260156	LNCAPCLONEFGC	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.26896140695371695	[2679]	[2724,2925,3081,2992]	4	hSpCas9	negative selection	7655832
68930638	68930661	6	+	27260156	LNCAPCLONEFGC	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.0465611769421273	[392]	[338,402,416,316]	0	hSpCas9	negative selection	7655833
68943821	68943844	6	+	27260156	PANC0327	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.42633486673002197	[701]	[967,980,793,600]	6	hSpCas9	negative selection	7712798
68639385	68639408	6	+	27260156	PANC0327	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.3129011646702392	[552]	[845,539,543,538]	4	hSpCas9	negative selection	7712799
68639153	68639176	6	+	27260156	PANC0327	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.5122142345103698	[916]	[1676,819,1074,1160]	7	hSpCas9	negative selection	7712800
68930601	68930624	6	+	27260156	PANC0327	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.2909123239015169	[326]	[388,212,593,246]	4	hSpCas9	negative selection	7777082
68943910	68943933	6	+	27260156	PANC0327	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.03295604922813711	[2679]	[2627,2301,2433,2410]	0	hSpCas9	negative selection	7777083
68930638	68930661	6	+	27260156	PANC0327	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.32862379065348923	[392]	[429,468,483,365]	5	hSpCas9	negative selection	7777084
68943821	68943844	6	+	27260156	NCIH2009	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.4089814351533968	[701]	[1560,1010,1388]	5	hSpCas9	negative selection	7834049
68639385	68639408	6	+	27260156	NCIH2009	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.6409519465332201	[552]	[1742,804,1177]	8	hSpCas9	negative selection	7834050
68639153	68639176	6	+	27260156	NCIH2009	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.39681938070964995	[916]	[2132,1509,1505]	5	hSpCas9	negative selection	7834051
68930601	68930624	6	+	27260156	NCIH2009	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.5337531766044054	[326]	[910,574,547]	7	hSpCas9	negative selection	7898333
68943910	68943933	6	+	27260156	NCIH2009	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.29949725651769343	[2679]	[6199,3979,3962]	4	hSpCas9	negative selection	7898334
68930638	68930661	6	+	27260156	NCIH2009	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.18809883658894466	[392]	[490,363,593]	-3	hSpCas9	negative selection	7898335
68943821	68943844	6	+	27260156	NCIH1373	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.22230238650574086	[701]	[780,921,619,355]	2	hSpCas9	negative selection	7955300
68639385	68639408	6	+	27260156	NCIH1373	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.7349996329630567	[552]	[892,1155,942,288]	7	hSpCas9	negative selection	7955301
68639153	68639176	6	+	27260156	NCIH1373	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.7675552620317362	[916]	[1863,1669,1703,467]	7	hSpCas9	negative selection	7955302
68930601	68930624	6	+	27260156	NCIH1373	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.34727336105191464	[326]	[516,384,714,63]	3	hSpCas9	negative selection	8019584
68943910	68943933	6	+	27260156	NCIH1373	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.2607117141241533	[2679]	[3189,3296,3820,1066]	2	hSpCas9	negative selection	8019585
68930638	68930661	6	+	27260156	NCIH1373	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.29805083813531397	[392]	[500,273,1108,71]	3	hSpCas9	negative selection	8019586
68943821	68943844	6	+	27260156	PATU8902	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.790518006411655	[701]	[1750,2243,1390,1409]	8	hSpCas9	negative selection	8076551
68639385	68639408	6	+	27260156	PATU8902	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.6548724498256159	[552]	[1494,1316,984,1083]	7	hSpCas9	negative selection	8076552
68639153	68639176	6	+	27260156	PATU8902	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.5367470207399342	[916]	[2110,2158,1632,1505]	5	hSpCas9	negative selection	8076553
68930601	68930624	6	+	27260156	PATU8902	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.4148069155575192	[326]	[815,342,484,834]	4	hSpCas9	negative selection	8140835
68943910	68943933	6	+	27260156	PATU8902	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.346120389049549	[2679]	[4423,4463,4460,5792]	3	hSpCas9	negative selection	8140836
68930638	68930661	6	+	27260156	PATU8902	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.685255623830792	[392]	[1035,813,565,1216]	7	hSpCas9	negative selection	8140837
68943821	68943844	6	+	27260156	PANC1	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.385849771008104	[701]	[871,906,743,658]	6	hSpCas9	negative selection	8197802
68639385	68639408	6	+	27260156	PANC1	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.6996332892519037	[552]	[701,1044,755,647]	9	hSpCas9	negative selection	8197803
68639153	68639176	6	+	27260156	PANC1	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.2597402539051309	[916]	[1105,1198,812,722]	4	hSpCas9	negative selection	8197804
68930601	68930624	6	+	27260156	PANC1	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.13609253342514693	[326]	[389,446,231,203]	2	hSpCas9	negative selection	8262086
68943910	68943933	6	+	27260156	PANC1	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.33951367146580047	[2679]	[2826,3646,2689,2634]	5	hSpCas9	negative selection	8262087
68930638	68930661	6	+	27260156	PANC1	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.23698839739878777	[392]	[458,462,390,299]	4	hSpCas9	negative selection	8262088
68943821	68943844	6	+	27260156	PANC0813	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.3186309091215296	[701]	[1252,900,1132,855]	5	hSpCas9	negative selection	8319053
68639385	68639408	6	+	27260156	PANC0813	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.6054313205362836	[552]	[929,1203,836,974]	8	hSpCas9	negative selection	8319054
68639153	68639176	6	+	27260156	PANC0813	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.3525767188714263	[916]	[1631,1342,1362,1194]	5	hSpCas9	negative selection	8319055
68930601	68930624	6	+	27260156	PANC0813	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.6585085390783825	[326]	[541,686,718,477]	9	hSpCas9	negative selection	8383337
68943910	68943933	6	+	27260156	PANC0813	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.035462997120081496	[2679]	[3440,3496,2829,3153]	0	hSpCas9	negative selection	8383338
68930638	68930661	6	+	27260156	PANC0813	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.1960312817497165	[392]	[620,345,281,382]	-3	hSpCas9	negative selection	8383339
68943821	68943844	6	+	27260156	RDES	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.3816872203131665	[701]	[756,1026,1291,1198]	6	hSpCas9	negative selection	8440304
68639385	68639408	6	+	27260156	RDES	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.40506884735791493	[552]	[686,748,868,1124]	6	hSpCas9	negative selection	8440305
68639153	68639176	6	+	27260156	RDES	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.060203579249418326	[916]	[884,1116,1022,1431]	1	hSpCas9	negative selection	8440306
68930601	68930624	6	+	27260156	RDES	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.43624445860159017	[326]	[439,503,505,597]	7	hSpCas9	negative selection	8504588
68943910	68943933	6	+	27260156	RDES	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.13174421003205916	[2679]	[2786,3308,3558,3980]	2	hSpCas9	negative selection	8504589
68930638	68930661	6	+	27260156	RDES	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.006869960524211238	[392]	[268,460,434,697]	0	hSpCas9	negative selection	8504590
68943821	68943844	6	+	27260156	PC3	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.2667686344371939	[701]	[494,751,1217,1141]	6	hSpCas9	negative selection	8561555
68639385	68639408	6	+	27260156	PC3	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.0846330793618855	[552]	[325,543,1058,661]	2	hSpCas9	negative selection	8561556
68639153	68639176	6	+	27260156	PC3	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.17773829575231004	[916]	[722,930,1682,1084]	4	hSpCas9	negative selection	8561557
68930601	68930624	6	+	27260156	PC3	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.20465065518498698	[326]	[232,435,273,548]	4	hSpCas9	negative selection	8625839
68943910	68943933	6	+	27260156	PC3	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.25235295490079546	[2679]	[2143,2951,4971,3508]	5	hSpCas9	negative selection	8625840
68930638	68930661	6	+	27260156	PC3	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.12182283100810004	[392]	[197,253,789,414]	-3	hSpCas9	negative selection	8625841
68943821	68943844	6	+	27260156	PATU8988T	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.5888180557706406	[701]	[900,925,1144,1104]	8	hSpCas9	negative selection	8682806
68639385	68639408	6	+	27260156	PATU8988T	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.2486855639532828	[552]	[566,610,761,591]	4	hSpCas9	negative selection	8682807
68639153	68639176	6	+	27260156	PATU8988T	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.06481604023451204	[916]	[768,779,1001,1159]	1	hSpCas9	negative selection	8682808
68930601	68930624	6	+	27260156	PATU8988T	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.1193358486337931	[326]	[306,302,317,449]	2	hSpCas9	negative selection	8747090
68943910	68943933	6	+	27260156	PATU8988T	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.27299136060031337	[2679]	[3210,3139,2952,3222]	5	hSpCas9	negative selection	8747091
68930638	68930661	6	+	27260156	PATU8988T	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.13931081762710187	[392]	[379,469,310,526]	2	hSpCas9	negative selection	8747092
68943821	68943844	6	+	27260156	T47D	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.24822204924485392	[701]	[961,1005,952,960]	5	hSpCas9	negative selection	8804057
68639385	68639408	6	+	27260156	T47D	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.24489949557539656	[552]	[784,744,683,844]	5	hSpCas9	negative selection	8804058
68639153	68639176	6	+	27260156	T47D	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.2451940748668796	[916]	[1180,1240,1161,1490]	5	hSpCas9	negative selection	8804059
68930601	68930624	6	+	27260156	T47D	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.18284935130433377	[326]	[453,438,373,463]	4	hSpCas9	negative selection	8868341
68943910	68943933	6	+	27260156	T47D	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.29605125725690185	[2679]	[4076,3370,3890,4039]	6	hSpCas9	negative selection	8868342
68930638	68930661	6	+	27260156	T47D	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.05412383259493242	[392]	[543,412,425,381]	-1	hSpCas9	negative selection	8868343
68943821	68943844	6	+	27260156	SU8686	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.2559412022333414	[701]	[812,771,852,901]	4	hSpCas9	negative selection	8925308
68639385	68639408	6	+	27260156	SU8686	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.6010527669475632	[552]	[677,756,967,970]	8	hSpCas9	negative selection	8925309
68639153	68639176	6	+	27260156	SU8686	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.3790724296106368	[916]	[1188,1042,1233,1290]	6	hSpCas9	negative selection	8925310
68930601	68930624	6	+	27260156	SU8686	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.20983078385081655	[326]	[274,351,396,509]	3	hSpCas9	negative selection	8989592
68943910	68943933	6	+	27260156	SU8686	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.2894805608260831	[2679]	[2794,2846,3510,4054]	5	hSpCas9	negative selection	8989593
68930638	68930661	6	+	27260156	SU8686	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.26965061394412454	[392]	[403,318,233,321]	-4	hSpCas9	negative selection	8989594
68943821	68943844	6	+	27260156	SKES1	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.19925571883731952	[701]	[664,740,871,890]	4	hSpCas9	negative selection	9046559
68639385	68639408	6	+	27260156	SKES1	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.10279864213630094	[552]	[650,665,536,533]	2	hSpCas9	negative selection	9046560
68639153	68639176	6	+	27260156	SKES1	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.20903996561344595	[916]	[1377,1063,961,881]	4	hSpCas9	negative selection	9046561
68930601	68930624	6	+	27260156	SKES1	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.20128380011629043	[326]	[392,365,366,371]	4	hSpCas9	negative selection	9110843
68943910	68943933	6	+	27260156	SKES1	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.1340415471697569	[2679]	[3186,3295,2812,2535]	3	hSpCas9	negative selection	9110844
68930638	68930661	6	+	27260156	SKES1	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.03820568203474445	[392]	[511,395,398,322]	0	hSpCas9	negative selection	9110845
68943821	68943844	6	+	27260156	TOV112D	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.07374210296288641	[701]	[833,713,666,744]	1	hSpCas9	negative selection	9167810
68639385	68639408	6	+	27260156	TOV112D	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.41363723903321725	[552]	[989,798,780,424]	7	hSpCas9	negative selection	9167811
68639153	68639176	6	+	27260156	TOV112D	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.32683973982941417	[916]	[1234,1590,818,1077]	6	hSpCas9	negative selection	9167812
68930601	68930624	6	+	27260156	TOV112D	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.06768230596053032	[326]	[546,448,236,186]	1	hSpCas9	negative selection	9232094
68943910	68943933	6	+	27260156	TOV112D	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.25982577827569786	[2679]	[3167,4326,3060,2581]	5	hSpCas9	negative selection	9232095
68930638	68930661	6	+	27260156	TOV112D	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.23300251433146668	[392]	[412,472,316,180]	-4	hSpCas9	negative selection	9232096
68943821	68943844	6	+	27260156	TC71	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.04411382878655268	[701]	[705,827,787,782]	1	hSpCas9	negative selection	9289061
68639385	68639408	6	+	27260156	TC71	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	-0.014312903701890922	[552]	[426,689,588,648]	0	hSpCas9	negative selection	9289062
68639153	68639176	6	+	27260156	TC71	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.1815699449669409	[916]	[967,1170,990,1350]	4	hSpCas9	negative selection	9289063
68930601	68930624	6	+	27260156	TC71	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.3396571855638992	[326]	[372,406,472,526]	7	hSpCas9	negative selection	9353345
68943910	68943933	6	+	27260156	TC71	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.22811521672914603	[2679]	[3405,3281,3554,3198]	5	hSpCas9	negative selection	9353346
68930638	68930661	6	+	27260156	TC71	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	-0.3091672382825416	[392]	[325,339,292,406]	-7	hSpCas9	negative selection	9353347
68943821	68943844	6	+	27260156	TC32	viability	TTATTACAGTACACGGAGTATGG	ADGRB3	ENSG00000135298	0.5155169043072516	[701]	[817,710,1251,1101]	8	hSpCas9	negative selection	9410312
68639385	68639408	6	+	27260156	TC32	viability	CCCAAGTCTGCAATCTTACCAGG	ADGRB3	ENSG00000135298	0.3818558798360794	[552]	[580,508,960,746]	6	hSpCas9	negative selection	9410313
68639153	68639176	6	+	27260156	TC32	viability	AAGGTCAGCCCAAGCCAGTTTGG	ADGRB3	ENSG00000135298	0.14984758175721768	[916]	[795,933,1088,997]	2	hSpCas9	negative selection	9410314
68930601	68930624	6	+	27260156	TC32	viability	CTCGATCTGTTCATGAAAAAAGG	ADGRB3	ENSG00000135298	0.14054943445921675	[326]	[385,216,487,307]	2	hSpCas9	negative selection	9474596
68943910	68943933	6	+	27260156	TC32	viability	TCATGCACACCTCCTCAGTATGG	ADGRB3	ENSG00000135298	0.19231451627297957	[2679]	[2701,2211,3148,3637]	3	hSpCas9	negative selection	9474597
68930638	68930661	6	+	27260156	TC32	viability	AGCTGATGCTGCTAAATTTATGG	ADGRB3	ENSG00000135298	0.1294217236237899	[392]	[281,338,560,481]	2	hSpCas9	negative selection	9474598