Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:2015
• Symbol:ADGRE1
• Description:adhesion G protein-coupled receptor E1

DataSource: http://genomecrispr.dkfz.de/#!/results/ADGRE1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
6905390	6905413	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCGCCCAGACTGGAGTGCAGGGG	ADGRE1	ENSG00000174837	0.35999765204224765	[28,7]	[7,0]	1	dCas9-VP64	positive selection	2386745
6921345	6921368	19	-	25494202	A375	resistance to PLX-4720 (puromycin)	TCGCTGCAACCTCTGCCTCCGGG	ADGRE1	ENSG00000174837	-0.9365880081613079	[154,441]	[7,61]	-5	dCas9-VP64	positive selection	2389218
6928894	6928917	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	GCGCCATTGCACTCCAGCCTAGG	ADGRE1	ENSG00000174837	-0.7836007518198642	[44,14]	[5,0]	-4	dCas9-VP64	positive selection	2394697
6913291	6913314	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	GCCTCAGCCTCCCAAGTAGCTAG	ADGRE1	ENSG00000174837	0.6911400425855385	[25,30]	[5,13]	3	dCas9-VP64	positive selection	2396482
6919462	6919485	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	GTGTGTGTGTGTGTGTGTGTTGG	ADGRE1	ENSG00000174837	4.847110262494055	[32,12]	[264,23]	9	dCas9-VP64	positive selection	2428820
6921327	6921350	19	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGAAGAATCGCTTGAACCCCGG	ADGRE1	ENSG00000174837	0.6947743245442068	[118,16]	[8,38]	3	dCas9-VP64	positive selection	2469063
6905390	6905413	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCGCCCAGACTGGAGTGCAGGGG	ADGRE1	ENSG00000174837	0.05401708914906567	[74,30]	[24,10]	0	dCas9-VP64	positive selection	2482000
6921345	6921368	19	-	25494202	A375	resistance to PLX-4720 (zeocin)	TCGCTGCAACCTCTGCCTCCGGG	ADGRE1	ENSG00000174837	-0.39148980799888866	[423,502]	[155,76]	-4	dCas9-VP64	positive selection	2484473
6928894	6928917	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	GCGCCATTGCACTCCAGCCTAGG	ADGRE1	ENSG00000174837	-1.3426926137865989	[87,148]	[18,10]	-9	dCas9-VP64	positive selection	2489952
6913291	6913314	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	GCCTCAGCCTCCCAAGTAGCTAG	ADGRE1	ENSG00000174837	0.4030393266100577	[90,274]	[19,131]	3	dCas9-VP64	positive selection	2491737
6919462	6919485	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	GTGTGTGTGTGTGTGTGTGTTGG	ADGRE1	ENSG00000174837	0.8889753160498469	[90,141]	[86,53]	6	dCas9-VP64	positive selection	2524075
6921327	6921350	19	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGAAGAATCGCTTGAACCCCGG	ADGRE1	ENSG00000174837	-1.217410828372933	[137,230]	[25,24]	-9	dCas9-VP64	positive selection	2564318
6919685	6919708	19	+	26780180	HT29	viability (Avana library 4 designs)	ATGACTGGAGAGAAGAAAGACGG	ADGRE1	ENSG00000174837	2.64455826974562	[]	[]	8	hSpCas9	negative selection	3405089
6913788	6913811	19	-	26780180	HT29	viability (Avana library 4 designs)	GCCGGAGTGATATTTGCTGAGGG	ADGRE1	ENSG00000174837	0.868538359489914	[]	[]	3	hSpCas9	negative selection	3405090
6897253	6897276	19	-	26780180	HT29	viability (Avana library 4 designs)	GGGACCCAGTCATTTCCAGTGGG	ADGRE1	ENSG00000174837	0.485761776517771	[]	[]	1	hSpCas9	negative selection	3405091
6906502	6906525	19	-	26780180	HT29	viability (Avana library 4 designs)	TGCATATGCAGGTTTCACTGCGG	ADGRE1	ENSG00000174837	-0.303969052657278	[]	[]	-5	hSpCas9	negative selection	3405092
6906502	6906525	19	-	26780180	A375	viability (Avana lentiCRISPRv2)	TGCATATGCAGGTTTCACTGCGG	ADGRE1	ENSG00000174837	2.3422721261675	[]	[]	3	hSpCas9	negative selection	3476935
6897253	6897276	19	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGGACCCAGTCATTTCCAGTGGG	ADGRE1	ENSG00000174837	3.11309454663115	[]	[]	5	hSpCas9	negative selection	3476936
6913788	6913811	19	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCCGGAGTGATATTTGCTGAGGG	ADGRE1	ENSG00000174837	4.23254732625379	[]	[]	7	hSpCas9	negative selection	3476937
6919685	6919708	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	ATGACTGGAGAGAAGAAAGACGG	ADGRE1	ENSG00000174837	-7.91211522198861	[]	[]	-7	hSpCas9	negative selection	3476938
6906476	6906499	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCAGATCCAGCAATGCCAAGAGG	ADGRE1	ENSG00000174837	1.67076221879739	[]	[]	2	hSpCas9	negative selection	3476939
6890522	6890545	19	+	26780180	A375	viability (Avana lentiCRISPRv2)	ACACGGAAACCAAACACAAAGGG	ADGRE1	ENSG00000174837	-1.57102938470643	[]	[]	-2	hSpCas9	negative selection	3476940
6906502	6906525	19	-	26780180	A375	viability (Avana lentiGuide)	TGCATATGCAGGTTTCACTGCGG	ADGRE1	ENSG00000174837	-3.18305814583085	[]	[]	-5	hSpCas9	negative selection	3585594
6897253	6897276	19	-	26780180	A375	viability (Avana lentiGuide)	GGGACCCAGTCATTTCCAGTGGG	ADGRE1	ENSG00000174837	1.35810213971034	[]	[]	1	hSpCas9	negative selection	3585595
6913788	6913811	19	-	26780180	A375	viability (Avana lentiGuide)	GCCGGAGTGATATTTGCTGAGGG	ADGRE1	ENSG00000174837	-5.95506957502238	[]	[]	-8	hSpCas9	negative selection	3585596
6919685	6919708	19	+	26780180	A375	viability (Avana lentiGuide)	ATGACTGGAGAGAAGAAAGACGG	ADGRE1	ENSG00000174837	9.75979707972604	[]	[]	6	hSpCas9	negative selection	3585597
6906476	6906499	19	+	26780180	A375	viability (Avana lentiGuide)	GCAGATCCAGCAATGCCAAGAGG	ADGRE1	ENSG00000174837	-5.28971485012176	[]	[]	-8	hSpCas9	negative selection	3585598
6890522	6890545	19	+	26780180	A375	viability (Avana lentiGuide)	ACACGGAAACCAAACACAAAGGG	ADGRE1	ENSG00000174837	2.37692596648104	[]	[]	2	hSpCas9	negative selection	3585599
6906502	6906525	19	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGCATATGCAGGTTTCACTGCGG	ADGRE1	ENSG00000174837	0.09784490470583433	[5]	[5,5]	2	hSpCas9	positive selection	3694253
6897253	6897276	19	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGGACCCAGTCATTTCCAGTGGG	ADGRE1	ENSG00000174837	-0.36317753501894934	[4]	[4,1]	-5	hSpCas9	positive selection	3694254
6913788	6913811	19	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCCGGAGTGATATTTGCTGAGGG	ADGRE1	ENSG00000174837	0.2937420967108386	[4]	[5,5]	8	hSpCas9	positive selection	3694255
6919685	6919708	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATGACTGGAGAGAAGAAAGACGG	ADGRE1	ENSG00000174837	-0.8241167164508287	[5]	[4,1]	-8	hSpCas9	positive selection	3694256
6906476	6906499	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAGATCCAGCAATGCCAAGAGG	ADGRE1	ENSG00000174837	0.18356213021728884	[5]	[6,5]	5	hSpCas9	positive selection	3694257
6890522	6890545	19	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ACACGGAAACCAAACACAAAGGG	ADGRE1	ENSG00000174837	-0.45895600098737743	[4]	[2,3]	-6	hSpCas9	positive selection	3694258
6906502	6906525	19	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGCATATGCAGGTTTCACTGCGG	ADGRE1	ENSG00000174837	0.21084005525139718	[5]	[5,5]	5	hSpCas9	positive selection	3802860
6897253	6897276	19	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGGACCCAGTCATTTCCAGTGGG	ADGRE1	ENSG00000174837	-0.4479490346323002	[5]	[2,4]	-5	hSpCas9	positive selection	3802861
6913788	6913811	19	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCCGGAGTGATATTTGCTGAGGG	ADGRE1	ENSG00000174837	0.1049004850034582	[5]	[4,5]	2	hSpCas9	positive selection	3802862
6919685	6919708	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATGACTGGAGAGAAGAAAGACGG	ADGRE1	ENSG00000174837	-0.16893414486160307	[5]	[4,2]	-2	hSpCas9	positive selection	3802863
6906476	6906499	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAGATCCAGCAATGCCAAGAGG	ADGRE1	ENSG00000174837	0.2234341023174698	[5]	[6,3]	6	hSpCas9	positive selection	3802864
6890522	6890545	19	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ACACGGAAACCAAACACAAAGGG	ADGRE1	ENSG00000174837	-0.24788584699352845	[4]	[3,2]	-3	hSpCas9	positive selection	3802865
6887629	6887652	19	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CCTCACACTCACCCCAGAAGAGG	ADGRE1	ENSG00000174837	0.006089123314565681	[4]	[2,3]	0	hSpCas9	positive selection	4134666
6890481	6890504	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.2208645460964293	[5]	[4,4]	5	hSpCas9	positive selection	4134667
6887616	6887639	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.2989909700442588	[7]	[5,6]	7	hSpCas9	positive selection	4134668
6887629	6887652	19	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CCTCACACTCACCCCAGAAGAGG	ADGRE1	ENSG00000174837	0.7269762263800609	[5]	[5,4,2,3]	5	hSpCas9	positive selection	4198688
6890481	6890504	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.6921532876273992	[5]	[5,4,2,3]	4	hSpCas9	positive selection	4198689
6887616	6887639	19	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	1.123089661161473	[6]	[6,6,4,7]	8	hSpCas9	positive selection	4198690
6890531	6890554	19	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.4836984471680467	[3]	[4,3]	8	hSpCas9	positive selection	4268773
6890481	6890504	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	-0.22539191195765082	[2]	[2,0]	-4	hSpCas9	positive selection	4268774
6887616	6887639	19	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.4240748865549106	[3]	[4,3]	8	hSpCas9	positive selection	4333038
6887623	6887646	19	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-0.13242135383935927	[0]	[0,0]	-3	hSpCas9	positive selection	4333039
6890531	6890554	19	-	27260156	BXPC3	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.4827459272612479	[792]	[960,1117,1417,1157]	8	hSpCas9	negative selection	5541233
6890481	6890504	19	+	27260156	BXPC3	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.5294231720012195	[285]	[362,479,390,501]	9	hSpCas9	negative selection	5541234
6887616	6887639	19	+	27260156	BXPC3	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.3119753330420326	[891]	[1078,1019,1097,1481]	6	hSpCas9	negative selection	5605498
6887623	6887646	19	-	27260156	BXPC3	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-0.012946047262980542	[29]	[58,18,15,26]	0	hSpCas9	negative selection	5605499
6890531	6890554	19	-	27260156	A673	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.3815184305922098	[792]	[1448,1148,1227,1154]	8	hSpCas9	negative selection	5662484
6890481	6890504	19	+	27260156	A673	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.28893292316460567	[285]	[343,415,431,479]	6	hSpCas9	negative selection	5662485
6887616	6887639	19	+	27260156	A673	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.3159366610133415	[891]	[1472,1210,1342,1321]	7	hSpCas9	negative selection	5726749
6887623	6887646	19	-	27260156	A673	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-0.06398010459111658	[29]	[21,28,40,44]	-1	hSpCas9	negative selection	5726750
6890531	6890554	19	-	27260156	A375	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.6027541847784398	[792]	[1357,1632,1587,1108]	8	hSpCas9	negative selection	5783735
6890481	6890504	19	+	27260156	A375	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.13766578654248707	[285]	[177,321,400,538]	2	hSpCas9	negative selection	5783736
6887616	6887639	19	+	27260156	A375	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.7827150812996165	[891]	[2122,2175,1540,1422]	9	hSpCas9	negative selection	5848000
6887623	6887646	19	-	27260156	A375	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	0.055153895952051	[29]	[79,45,1,20]	0	hSpCas9	negative selection	5848001
6890531	6890554	19	-	27260156	COLO741	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.3152158180291652	[792]	[1243,1234,1295]	6	hSpCas9	negative selection	5904986
6890481	6890504	19	+	27260156	COLO741	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	-0.11780746143848408	[285]	[504,216,303]	-3	hSpCas9	negative selection	5904987
6887616	6887639	19	+	27260156	COLO741	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.370817974874902	[891]	[1564,1588,1285]	7	hSpCas9	negative selection	5969251
6887623	6887646	19	-	27260156	COLO741	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-0.36271647114668815	[29]	[58,19,13]	-7	hSpCas9	negative selection	5969252
6890531	6890554	19	-	27260156	CAL120	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.6541427949850503	[792]	[1723,1528,1432]	8	hSpCas9	negative selection	6026237
6890481	6890504	19	+	27260156	CAL120	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	-0.2860233683999793	[285]	[436,202,257]	-4	hSpCas9	negative selection	6026238
6887616	6887639	19	+	27260156	CAL120	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.5314083585911932	[891]	[1761,1580,1494]	7	hSpCas9	negative selection	6090502
6887623	6887646	19	-	27260156	CAL120	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	0.1691881655513212	[29]	[0,34,82]	2	hSpCas9	negative selection	6090503
6890531	6890554	19	-	27260156	CADOES1	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.7851053897070625	[792]	[1302,1282,1218,1278]	9	hSpCas9	negative selection	6147488
6890481	6890504	19	+	27260156	CADOES1	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.5693803509690594	[285]	[438,376,461,296]	8	hSpCas9	negative selection	6147489
6887616	6887639	19	+	27260156	CADOES1	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.6390648225113463	[891]	[1417,993,1434,1320]	9	hSpCas9	negative selection	6211753
6887623	6887646	19	-	27260156	CADOES1	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-1.1174299366454679	[29]	[20,23,4,0]	-9	hSpCas9	negative selection	6211754
6890531	6890554	19	-	27260156	EWS502	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.481865830604432	[792]	[1140,888,1062,1641]	8	hSpCas9	negative selection	6268739
6890481	6890504	19	+	27260156	EWS502	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.32531749613290467	[285]	[318,300,422,492]	6	hSpCas9	negative selection	6268740
6887616	6887639	19	+	27260156	EWS502	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.579986464890979	[891]	[1074,1388,1560,1681]	8	hSpCas9	negative selection	6333004
6887623	6887646	19	-	27260156	EWS502	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-0.22238053013042736	[29]	[54,17,13,17]	-4	hSpCas9	negative selection	6333005
6890531	6890554	19	-	27260156	EW8	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.5813700518766843	[792]	[1135,873,844,1026]	8	hSpCas9	negative selection	6389990
6890481	6890504	19	+	27260156	EW8	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.0970170341552089	[285]	[216,220,284,257]	1	hSpCas9	negative selection	6389991
6887616	6887639	19	+	27260156	EW8	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.33689649693295987	[891]	[1163,957,769,809]	6	hSpCas9	negative selection	6454255
6887623	6887646	19	-	27260156	EW8	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	0.08204786739601966	[29]	[17,53,14,16]	1	hSpCas9	negative selection	6454256
6890531	6890554	19	-	27260156	CORL105	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.6073172843501716	[792]	[1448,1366,1603,1268]	9	hSpCas9	negative selection	6511241
6890481	6890504	19	+	27260156	CORL105	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.22386238458960334	[285]	[437,362,339,416]	4	hSpCas9	negative selection	6511242
6887616	6887639	19	+	27260156	CORL105	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.19891700700678083	[891]	[1130,1051,1443,1205]	4	hSpCas9	negative selection	6575506
6887623	6887646	19	-	27260156	CORL105	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-0.6933409050809156	[29]	[18,42,18,4]	-8	hSpCas9	negative selection	6575507
6890531	6890554	19	-	27260156	HS294T	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.5091767831425157	[792]	[356,375,563,460]	6	hSpCas9	negative selection	6632492
6890481	6890504	19	+	27260156	HS294T	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.2709167897812894	[285]	[153,123,147,99]	3	hSpCas9	negative selection	6632493
6887616	6887639	19	+	27260156	HS294T	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.3889437331420246	[891]	[399,326,606,485]	5	hSpCas9	negative selection	6696757
6887623	6887646	19	-	27260156	HS294T	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-2.0979103387251326	[29]	[0,3,2,2]	-9	hSpCas9	negative selection	6696758
6890531	6890554	19	-	27260156	HCC44	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.4961166604585078	[792]	[1362,1405,1381,918]	7	hSpCas9	negative selection	6753743
6890481	6890504	19	+	27260156	HCC44	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	-0.13540580292042537	[285]	[220,205,549,249]	-2	hSpCas9	negative selection	6753744
6887616	6887639	19	+	27260156	HCC44	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.605383714968292	[891]	[1492,1310,1706,1668]	8	hSpCas9	negative selection	6818008
6887623	6887646	19	-	27260156	HCC44	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	0.38680956920674925	[29]	[51,37,75,18]	6	hSpCas9	negative selection	6818009
6890531	6890554	19	-	27260156	G402	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.7008119497714361	[792]	[1467,1289,1382,2086]	8	hSpCas9	negative selection	6874994
6890481	6890504	19	+	27260156	G402	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.22753819477234366	[285]	[498,239,550,348]	3	hSpCas9	negative selection	6874995
6887616	6887639	19	+	27260156	G402	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.8165293591145272	[891]	[2585,1986,1783,1427]	8	hSpCas9	negative selection	6939259
6887623	6887646	19	-	27260156	G402	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-0.8848963634054399	[29]	[60,0,21,0]	-8	hSpCas9	negative selection	6939260
6890531	6890554	19	-	27260156	L33	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.5478265290476577	[792]	[1054,443,697,1387]	9	hSpCas9	negative selection	6996245
6890481	6890504	19	+	27260156	L33	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.3418478378348385	[285]	[335,118,291,359]	7	hSpCas9	negative selection	6996246
6887616	6887639	19	+	27260156	L33	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.25767721499618645	[891]	[997,453,655,1116]	5	hSpCas9	negative selection	7060510
6887623	6887646	19	-	27260156	L33	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-1.0908822742876123	[29]	[4,10,7,11]	-9	hSpCas9	negative selection	7060511
6890531	6890554	19	-	27260156	K562	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.40400025873455825	[792]	[1010,802,1055,858]	5	hSpCas9	negative selection	7117496
6890481	6890504	19	+	27260156	K562	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.151718129967357	[285]	[261,143,290,405]	1	hSpCas9	negative selection	7117497
6887616	6887639	19	+	27260156	K562	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.9478451018156636	[891]	[1935,1426,1375,1404]	9	hSpCas9	negative selection	7181761
6887623	6887646	19	-	27260156	K562	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-2.73228250003755	[29]	[0,3,8,1]	-9	hSpCas9	negative selection	7181762
6890531	6890554	19	-	27260156	HT29	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.5820668014163085	[792]	[1450,1444,1382,1478]	9	hSpCas9	negative selection	7238747
6890481	6890504	19	+	27260156	HT29	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.23586688532130107	[285]	[376,352,448,443]	4	hSpCas9	negative selection	7238748
6887616	6887639	19	+	27260156	HT29	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.5311438901899356	[891]	[1681,1621,1516,1461]	8	hSpCas9	negative selection	7303012
6887623	6887646	19	-	27260156	HT29	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-1.3991785326244908	[29]	[25,7,19,2]	-9	hSpCas9	negative selection	7303013
6890531	6890554	19	-	27260156	MHHES1	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.6337761447258693	[792]	[1872,1204,1351,1171]	9	hSpCas9	negative selection	7359998
6890481	6890504	19	+	27260156	MHHES1	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	-0.011007857971476187	[285]	[408,274,201,376]	0	hSpCas9	negative selection	7359999
6887616	6887639	19	+	27260156	MHHES1	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.20844627026101692	[891]	[1144,1310,1282,942]	4	hSpCas9	negative selection	7424263
6887623	6887646	19	-	27260156	MHHES1	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-1.716847785280248	[29]	[35,0,0,5]	-9	hSpCas9	negative selection	7424264
6890531	6890554	19	-	27260156	MEWO	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.2828183667137373	[792]	[1018,712,998]	6	hSpCas9	negative selection	7481249
6890481	6890504	19	+	27260156	MEWO	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.1487338176805335	[285]	[236,350,289]	3	hSpCas9	negative selection	7481250
6887616	6887639	19	+	27260156	MEWO	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.562705340791909	[891]	[1340,1145,1231]	9	hSpCas9	negative selection	7545514
6887623	6887646	19	-	27260156	MEWO	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	0.7088493086392873	[29]	[31,30,71]	9	hSpCas9	negative selection	7545515
6890531	6890554	19	-	27260156	LNCAPCLONEFGC	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.542034626264886	[792]	[958,882,1271,1114]	8	hSpCas9	negative selection	7602500
6890481	6890504	19	+	27260156	LNCAPCLONEFGC	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.4427881094749506	[285]	[392,273,461,299]	7	hSpCas9	negative selection	7602501
6887616	6887639	19	+	27260156	LNCAPCLONEFGC	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.8062710804712049	[891]	[1430,1495,1600,1144]	9	hSpCas9	negative selection	7666765
6887623	6887646	19	-	27260156	LNCAPCLONEFGC	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	0.1909050729083055	[29]	[48,6,28,39]	3	hSpCas9	negative selection	7666766
6890531	6890554	19	-	27260156	PANC0327	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.7284689418473252	[792]	[1291,1185,1101,1095]	9	hSpCas9	negative selection	7723751
6890481	6890504	19	+	27260156	PANC0327	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.543061620866585	[285]	[298,281,358,545]	7	hSpCas9	negative selection	7723752
6887616	6887639	19	+	27260156	PANC0327	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.2856899689939755	[891]	[915,830,1186,942]	4	hSpCas9	negative selection	7788016
6887623	6887646	19	-	27260156	PANC0327	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-0.5894460553114249	[29]	[9,3,33,23]	-7	hSpCas9	negative selection	7788017
6890531	6890554	19	-	27260156	NCIH2009	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.7728431033457764	[792]	[2177,2020,1530]	9	hSpCas9	negative selection	7845002
6890481	6890504	19	+	27260156	NCIH2009	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.5917910997933742	[285]	[707,687,428]	7	hSpCas9	negative selection	7845003
6887616	6887639	19	+	27260156	NCIH2009	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.5905367511215508	[891]	[2110,1492,2075]	7	hSpCas9	negative selection	7909267
6887623	6887646	19	-	27260156	NCIH2009	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-1.8772233590775689	[29]	[29,4,2]	-9	hSpCas9	negative selection	7909268
6890531	6890554	19	-	27260156	NCIH1373	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	1.2152120817935006	[792]	[1498,2491,1949,571]	9	hSpCas9	negative selection	7966253
6890481	6890504	19	+	27260156	NCIH1373	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.23354952093028825	[285]	[456,518,206,83]	2	hSpCas9	negative selection	7966254
6887616	6887639	19	+	27260156	NCIH1373	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.42230546674114533	[891]	[1597,1280,1319,312]	4	hSpCas9	negative selection	8030518
6887623	6887646	19	-	27260156	NCIH1373	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-2.86596719452158	[29]	[2,1,5,1]	-9	hSpCas9	negative selection	8030519
6890531	6890554	19	-	27260156	PATU8902	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.8406135206716158	[792]	[1797,2389,1373,2563]	8	hSpCas9	negative selection	8087504
6890481	6890504	19	+	27260156	PATU8902	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.38057637590319326	[285]	[562,438,379,750]	4	hSpCas9	negative selection	8087505
6887616	6887639	19	+	27260156	PATU8902	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.9349271834916214	[891]	[2628,1835,1920,3320]	8	hSpCas9	negative selection	8151769
6887623	6887646	19	-	27260156	PATU8902	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-1.4324120891034	[29]	[1,57,1,1]	-8	hSpCas9	negative selection	8151770
6890531	6890554	19	-	27260156	PANC1	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.7904858071413171	[792]	[1025,1402,1367,979]	9	hSpCas9	negative selection	8208755
6890481	6890504	19	+	27260156	PANC1	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.5468136238930844	[285]	[402,457,381,227]	8	hSpCas9	negative selection	8208756
6887616	6887639	19	+	27260156	PANC1	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.4117566417074846	[891]	[1135,907,1024,972]	6	hSpCas9	negative selection	8273020
6887623	6887646	19	-	27260156	PANC1	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	0.3246111273186516	[29]	[35,4,62,20]	5	hSpCas9	negative selection	8273021
6890531	6890554	19	-	27260156	PANC0813	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.7306890854437084	[792]	[1548,1538,1671,1427]	9	hSpCas9	negative selection	8330006
6890481	6890504	19	+	27260156	PANC0813	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.42824848464964993	[285]	[511,588,430,289]	7	hSpCas9	negative selection	8330007
6887616	6887639	19	+	27260156	PANC0813	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.3477258227563268	[891]	[1484,1288,1223,1345]	5	hSpCas9	negative selection	8394271
6887623	6887646	19	-	27260156	PANC0813	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	0.6046177953241236	[29]	[13,66,29,96]	8	hSpCas9	negative selection	8394272
6890531	6890554	19	-	27260156	RDES	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.6318793063806015	[792]	[1205,1239,1439,1852]	8	hSpCas9	negative selection	8451257
6890481	6890504	19	+	27260156	RDES	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.33881219725711725	[285]	[324,438,377,544]	5	hSpCas9	negative selection	8451258
6887616	6887639	19	+	27260156	RDES	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.49078576884184744	[891]	[1167,1514,1628,1472]	7	hSpCas9	negative selection	8515522
6887623	6887646	19	-	27260156	RDES	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-0.3053293795816834	[29]	[21,27,36,24]	-5	hSpCas9	negative selection	8515523
6890531	6890554	19	-	27260156	PC3	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.3382179972978653	[792]	[587,959,1493,1248]	7	hSpCas9	negative selection	8572508
6890481	6890504	19	+	27260156	PC3	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	-0.13263194880845652	[285]	[207,190,323,340]	-3	hSpCas9	negative selection	8572509
6887616	6887639	19	+	27260156	PC3	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.16808399076266223	[891]	[582,930,1701,1155]	4	hSpCas9	negative selection	8636773
6887623	6887646	19	-	27260156	PC3	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-1.2161468239692321	[29]	[3,19,19,12]	-9	hSpCas9	negative selection	8636774
6890531	6890554	19	-	27260156	PATU8988T	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.3215614688755116	[792]	[990,924,1082,814]	5	hSpCas9	negative selection	8693759
6890481	6890504	19	+	27260156	PATU8988T	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.3123129824001483	[285]	[287,346,317,426]	5	hSpCas9	negative selection	8693760
6887616	6887639	19	+	27260156	PATU8988T	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.5403391725186623	[891]	[1374,1334,1394,884]	8	hSpCas9	negative selection	8758024
6887623	6887646	19	-	27260156	PATU8988T	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	0.08465324335817481	[29]	[73,35,3,7]	1	hSpCas9	negative selection	8758025
6890531	6890554	19	-	27260156	T47D	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.5921875690112236	[792]	[1376,1466,1425,1289]	9	hSpCas9	negative selection	8815010
6890481	6890504	19	+	27260156	T47D	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.23743313672932564	[285]	[401,275,435,468]	5	hSpCas9	negative selection	8815011
6887616	6887639	19	+	27260156	T47D	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.39556314758202327	[891]	[1340,1289,1379,1465]	8	hSpCas9	negative selection	8879275
6887623	6887646	19	-	27260156	T47D	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	0.46579646543696285	[29]	[48,31,48,64]	8	hSpCas9	negative selection	8879276
6890531	6890554	19	-	27260156	SU8686	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.6934893109224279	[792]	[1252,1135,1257,1482]	9	hSpCas9	negative selection	8936261
6890481	6890504	19	+	27260156	SU8686	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.4096937452775939	[285]	[338,289,370,546]	7	hSpCas9	negative selection	8936262
6887616	6887639	19	+	27260156	SU8686	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.3628619424676024	[891]	[969,873,1188,1644]	6	hSpCas9	negative selection	9000526
6887623	6887646	19	-	27260156	SU8686	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-2.2942731335826365	[29]	[13,0,1,6]	-9	hSpCas9	negative selection	9000527
6890531	6890554	19	-	27260156	SKES1	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.45847558739305294	[792]	[1224,1046,1035,1047]	8	hSpCas9	negative selection	9057512
6890481	6890504	19	+	27260156	SKES1	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	-0.1805835230357452	[285]	[299,249,268,197]	-4	hSpCas9	negative selection	9057513
6887616	6887639	19	+	27260156	SKES1	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.4438709155538566	[891]	[1438,1399,1035,1031]	8	hSpCas9	negative selection	9121777
6887623	6887646	19	-	27260156	SKES1	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-0.20825983426295958	[29]	[32,48,25,1]	-4	hSpCas9	negative selection	9121778
6890531	6890554	19	-	27260156	TOV112D	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.8830429715329812	[792]	[1401,1508,1622,1331]	9	hSpCas9	negative selection	9178763
6890481	6890504	19	+	27260156	TOV112D	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	-0.17183220878819327	[285]	[319,210,168,309]	-3	hSpCas9	negative selection	9178764
6887616	6887639	19	+	27260156	TOV112D	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.3390057152100422	[891]	[1336,1032,1055,1086]	6	hSpCas9	negative selection	9243028
6887623	6887646	19	-	27260156	TOV112D	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	-1.1259690488708345	[29]	[0,33,11,11]	-9	hSpCas9	negative selection	9243029
6890531	6890554	19	-	27260156	TC71	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.4520399336201052	[792]	[1123,1127,1172,1230]	9	hSpCas9	negative selection	9300014
6890481	6890504	19	+	27260156	TC71	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	-0.059536498990213405	[285]	[265,367,277,263]	-1	hSpCas9	negative selection	9300015
6887616	6887639	19	+	27260156	TC71	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.25758592303394245	[891]	[1107,1049,1077,1351]	6	hSpCas9	negative selection	9364279
6887623	6887646	19	-	27260156	TC71	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	0.7418888427968575	[29]	[42,92,28,50]	9	hSpCas9	negative selection	9364280
6890531	6890554	19	-	27260156	TC32	viability	GCCAACTTACCCTTTGTGTTTGG	ADGRE1	ENSG00000174837	0.5035601256469738	[792]	[1031,741,1453,1130]	8	hSpCas9	negative selection	9421265
6890481	6890504	19	+	27260156	TC32	viability	GATGTTGTGTTATGCACAGCTGG	ADGRE1	ENSG00000174837	0.24555487063804393	[285]	[299,132,411,512]	4	hSpCas9	negative selection	9421266
6887616	6887639	19	+	27260156	TC32	viability	GCTTCAACCTGCTCCTCTTCTGG	ADGRE1	ENSG00000174837	0.35703279105731334	[891]	[1000,736,1541,1175]	6	hSpCas9	negative selection	9485530
6887623	6887646	19	-	27260156	TC32	viability	ACTCACCCCAGAAGAGGAGCAGG	ADGRE1	ENSG00000174837	0.5435822793551943	[29]	[58,0,86,35]	8	hSpCas9	negative selection	9485531