Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:55054
• Symbol:ATG16L1
• Description:autophagy related 16 like 1

DataSource: http://genomecrispr.dkfz.de/#!/results/ATG16L1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
233273019	233273042	2	-	26472758	Jiyoye	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.7596917962266587	[111]	[142]	5	hSpCas9	negative selection	11755
233273019	233273042	CHR_HG2232_PATCH	-	26472758	Jiyoye	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000281089	0.7596917962266587	[111]	[142]	5	hSpCas9	negative selection	11756
233293271	233293294	2	+	26472758	Jiyoye	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-0.9367790197114881	[65]	[25]	-6	hSpCas9	negative selection	11757
233293271	233293294	CHR_HG2232_PATCH	+	26472758	Jiyoye	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000281089	-0.9367790197114881	[65]	[25]	-6	hSpCas9	negative selection	11758
233251858	233251881	CHR_HG2232_PATCH	-	26472758	Jiyoye	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000281089	0.31575235374227867	[113]	[106]	2	hSpCas9	negative selection	11759
233251858	233251881	2	-	26472758	Jiyoye	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.31575235374227867	[113]	[106]	2	hSpCas9	negative selection	11760
233251871	233251894	CHR_HG2232_PATCH	+	26472758	Jiyoye	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000281089	0.9007148544634349	[151]	[213]	6	hSpCas9	negative selection	11761
233251871	233251894	2	+	26472758	Jiyoye	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	0.9007148544634349	[151]	[213]	6	hSpCas9	negative selection	11762
233277626	233277649	2	-	26472758	Jiyoye	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	1.4578014545758413	[27]	[57]	8	hSpCas9	negative selection	11763
233277626	233277649	CHR_HG2232_PATCH	-	26472758	Jiyoye	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000281089	1.4578014545758413	[27]	[57]	8	hSpCas9	negative selection	11764
233292131	233292154	CHR_HG2232_PATCH	+	26472758	Jiyoye	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000281089	0.3112063229751513	[201]	[188]	2	hSpCas9	negative selection	11765
233292131	233292154	2	+	26472758	Jiyoye	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	0.3112063229751513	[201]	[188]	2	hSpCas9	negative selection	11766
233292391	233292414	2	-	26472758	Jiyoye	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	0.5853789470597834	[250]	[283]	4	hSpCas9	negative selection	11767
233292391	233292414	CHR_HG2232_PATCH	-	26472758	Jiyoye	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000281089	0.5853789470597834	[250]	[283]	4	hSpCas9	negative selection	11768
233293336	233293359	2	+	26472758	Jiyoye	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	-0.7837674012055218	[120]	[52]	-5	hSpCas9	negative selection	11769
233293336	233293359	CHR_HG2232_PATCH	+	26472758	Jiyoye	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000281089	-0.7837674012055218	[120]	[52]	-5	hSpCas9	negative selection	11770
233277618	233277641	CHR_HG2232_PATCH	+	26472758	Jiyoye	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000281089	0.6524821947903233	[231]	[274]	5	hSpCas9	negative selection	11771
233277618	233277641	2	+	26472758	Jiyoye	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	0.6524821947903233	[231]	[274]	5	hSpCas9	negative selection	11772
233293260	233293283	CHR_HG2232_PATCH	+	26472758	Jiyoye	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000281089	0.5237509583552521	[201]	[218]	4	hSpCas9	negative selection	11773
233293260	233293283	2	+	26472758	Jiyoye	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	0.5237509583552521	[201]	[218]	4	hSpCas9	negative selection	11774
233273019	233273042	2	-	26472758	KBM7	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-0.4171159759989471	[725,648]	[262,222]	-4	hSpCas9	negative selection	202873
233273019	233273042	CHR_HG2232_PATCH	-	26472758	KBM7	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000281089	-0.4171159759989471	[725,648]	[262,222]	-4	hSpCas9	negative selection	202874
233293271	233293294	2	+	26472758	KBM7	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-1.7438322873804981	[476,459]	[75,56]	-8	hSpCas9	negative selection	202875
233293271	233293294	CHR_HG2232_PATCH	+	26472758	KBM7	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000281089	-1.7438322873804981	[476,459]	[75,56]	-8	hSpCas9	negative selection	202876
233251858	233251881	CHR_HG2232_PATCH	-	26472758	KBM7	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000281089	0.41781669639689445	[640,437]	[333,333]	4	hSpCas9	negative selection	202877
233251858	233251881	2	-	26472758	KBM7	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.41781669639689445	[640,437]	[333,333]	4	hSpCas9	negative selection	202878
233251871	233251894	CHR_HG2232_PATCH	+	26472758	KBM7	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000281089	-0.5402215600250726	[734,692]	[206,252]	-5	hSpCas9	negative selection	202879
233251871	233251894	2	+	26472758	KBM7	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	-0.5402215600250726	[734,692]	[206,252]	-5	hSpCas9	negative selection	202880
233277626	233277649	2	-	26472758	KBM7	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	1.105174551891965	[255,160]	[187,223]	9	hSpCas9	negative selection	202881
233277626	233277649	CHR_HG2232_PATCH	-	26472758	KBM7	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000281089	1.105174551891965	[255,160]	[187,223]	9	hSpCas9	negative selection	202882
233292131	233292154	CHR_HG2232_PATCH	+	26472758	KBM7	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000281089	0.2212248609316983	[650,543]	[314,335]	2	hSpCas9	negative selection	202883
233292131	233292154	2	+	26472758	KBM7	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	0.2212248609316983	[650,543]	[314,335]	2	hSpCas9	negative selection	202884
233292391	233292414	2	-	26472758	KBM7	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	-0.10771749350696092	[1330,1055]	[371,646]	-1	hSpCas9	negative selection	202885
233292391	233292414	CHR_HG2232_PATCH	-	26472758	KBM7	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000281089	-0.10771749350696092	[1330,1055]	[371,646]	-1	hSpCas9	negative selection	202886
233293336	233293359	2	+	26472758	KBM7	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	-0.04313316196482575	[312,337]	[199,104]	0	hSpCas9	negative selection	202887
233293336	233293359	CHR_HG2232_PATCH	+	26472758	KBM7	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000281089	-0.04313316196482575	[312,337]	[199,104]	0	hSpCas9	negative selection	202888
233277618	233277641	CHR_HG2232_PATCH	+	26472758	KBM7	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000281089	0.5588651070866812	[1155,779]	[746,582]	6	hSpCas9	negative selection	202889
233277618	233277641	2	+	26472758	KBM7	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	0.5588651070866812	[1155,779]	[746,582]	6	hSpCas9	negative selection	202890
233293260	233293283	CHR_HG2232_PATCH	+	26472758	KBM7	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000281089	1.1213124716185048	[759,675]	[778,692]	9	hSpCas9	negative selection	202891
233293260	233293283	2	+	26472758	KBM7	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	1.1213124716185048	[759,675]	[778,692]	9	hSpCas9	negative selection	202892
233273019	233273042	2	-	26472758	Raji	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	1.201130031866796	[282]	[150]	9	hSpCas9	negative selection	393991
233273019	233273042	CHR_HG2232_PATCH	-	26472758	Raji	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000281089	1.201130031866796	[282]	[150]	9	hSpCas9	negative selection	393992
233293271	233293294	2	+	26472758	Raji	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-1.198424894150486	[177]	[17]	-7	hSpCas9	negative selection	393993
233293271	233293294	CHR_HG2232_PATCH	+	26472758	Raji	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000281089	-1.198424894150486	[177]	[17]	-7	hSpCas9	negative selection	393994
233251858	233251881	CHR_HG2232_PATCH	-	26472758	Raji	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000281089	0.43600628283497	[257]	[80]	4	hSpCas9	negative selection	393995
233251858	233251881	2	-	26472758	Raji	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.43600628283497	[257]	[80]	4	hSpCas9	negative selection	393996
233251871	233251894	CHR_HG2232_PATCH	+	26472758	Raji	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000281089	1.3028546573947588	[254]	[145]	9	hSpCas9	negative selection	393997
233251871	233251894	2	+	26472758	Raji	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	1.3028546573947588	[254]	[145]	9	hSpCas9	negative selection	393998
233277626	233277649	2	-	26472758	Raji	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	0.6615837823240687	[78]	[28]	6	hSpCas9	negative selection	393999
233277626	233277649	CHR_HG2232_PATCH	-	26472758	Raji	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000281089	0.6615837823240687	[78]	[28]	6	hSpCas9	negative selection	394000
233292131	233292154	CHR_HG2232_PATCH	+	26472758	Raji	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000281089	0.6464097519278966	[233]	[84]	6	hSpCas9	negative selection	394001
233292131	233292154	2	+	26472758	Raji	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	0.6464097519278966	[233]	[84]	6	hSpCas9	negative selection	394002
233292391	233292414	2	-	26472758	Raji	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	0.1451855680859837	[677]	[173]	1	hSpCas9	negative selection	394003
233292391	233292414	CHR_HG2232_PATCH	-	26472758	Raji	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000281089	0.1451855680859837	[677]	[173]	1	hSpCas9	negative selection	394004
233293336	233293359	2	+	26472758	Raji	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	0.2092631493928131	[163]	[43]	2	hSpCas9	negative selection	394005
233293336	233293359	CHR_HG2232_PATCH	+	26472758	Raji	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000281089	0.2092631493928131	[163]	[43]	2	hSpCas9	negative selection	394006
233277618	233277641	CHR_HG2232_PATCH	+	26472758	Raji	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000281089	0.3878000194356295	[549]	[166]	3	hSpCas9	negative selection	394007
233277618	233277641	2	+	26472758	Raji	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	0.3878000194356295	[549]	[166]	3	hSpCas9	negative selection	394008
233293260	233293283	CHR_HG2232_PATCH	+	26472758	Raji	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000281089	-0.05747047652129089	[425]	[94]	0	hSpCas9	negative selection	394009
233293260	233293283	2	+	26472758	Raji	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	-0.05747047652129089	[425]	[94]	0	hSpCas9	negative selection	394010
233273019	233273042	2	-	26472758	K562	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	1.2561719090921244	[488]	[985]	9	hSpCas9	negative selection	585109
233273019	233273042	CHR_HG2232_PATCH	-	26472758	K562	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000281089	1.2561719090921244	[488]	[985]	9	hSpCas9	negative selection	585110
233293271	233293294	2	+	26472758	K562	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-2.6565712665023873	[365]	[48]	-8	hSpCas9	negative selection	585111
233293271	233293294	CHR_HG2232_PATCH	+	26472758	K562	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000281089	-2.6565712665023873	[365]	[48]	-8	hSpCas9	negative selection	585112
233251858	233251881	CHR_HG2232_PATCH	-	26472758	K562	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000281089	0.4635360169700339	[377]	[439]	3	hSpCas9	negative selection	585113
233251858	233251881	2	-	26472758	K562	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.4635360169700339	[377]	[439]	3	hSpCas9	negative selection	585114
233251871	233251894	CHR_HG2232_PATCH	+	26472758	K562	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000281089	1.0232759339879363	[576]	[989]	8	hSpCas9	negative selection	585115
233251871	233251894	2	+	26472758	K562	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	1.0232759339879363	[576]	[989]	8	hSpCas9	negative selection	585116
233277626	233277649	2	-	26472758	K562	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	-0.3081222953623317	[197]	[134]	-2	hSpCas9	negative selection	585117
233277626	233277649	CHR_HG2232_PATCH	-	26472758	K562	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000281089	-0.3081222953623317	[197]	[134]	-2	hSpCas9	negative selection	585118
233292131	233292154	CHR_HG2232_PATCH	+	26472758	K562	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000281089	0.6572315618307769	[648]	[863]	5	hSpCas9	negative selection	585119
233292131	233292154	2	+	26472758	K562	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	0.6572315618307769	[648]	[863]	5	hSpCas9	negative selection	585120
233292391	233292414	2	-	26472758	K562	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	-0.028540892041807986	[1020]	[844]	0	hSpCas9	negative selection	585121
233292391	233292414	CHR_HG2232_PATCH	-	26472758	K562	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000281089	-0.028540892041807986	[1020]	[844]	0	hSpCas9	negative selection	585122
233293336	233293359	2	+	26472758	K562	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	0.8143418289234621	[224]	[333]	6	hSpCas9	negative selection	585123
233293336	233293359	CHR_HG2232_PATCH	+	26472758	K562	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000281089	0.8143418289234621	[224]	[333]	6	hSpCas9	negative selection	585124
233277618	233277641	CHR_HG2232_PATCH	+	26472758	K562	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000281089	0.6809359543557422	[749]	[1014]	5	hSpCas9	negative selection	585125
233277618	233277641	2	+	26472758	K562	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	0.6809359543557422	[749]	[1014]	5	hSpCas9	negative selection	585126
233293260	233293283	CHR_HG2232_PATCH	+	26472758	K562	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000281089	0.7531850489373686	[472]	[672]	6	hSpCas9	negative selection	585127
233293260	233293283	2	+	26472758	K562	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	0.7531850489373686	[472]	[672]	6	hSpCas9	negative selection	585128
233251858	233251881	2	-	26627737	DLD1	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.22119035563891987	[382]	[100,114,93]	-2	hSpCas9	negative selection	810942
233263181	233263204	2	+	26627737	DLD1	viability	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	-0.48919116741626667	[310]	[59,100,50]	-5	hSpCas9	negative selection	810943
233264015	233264038	2	+	26627737	DLD1	viability	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	0.09733127019858301	[255]	[27,171,63]	1	hSpCas9	negative selection	810944
233264910	233264933	2	+	26627737	DLD1	viability	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	0.26012673823674337	[193]	[88,112,24]	2	hSpCas9	negative selection	810945
233269995	233270018	2	+	26627737	DLD1	viability	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.9755240469645973	[304]	[211,229,130]	8	hSpCas9	negative selection	810946
233274728	233274751	2	-	26627737	DLD1	viability	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.720187494486508	[910]	[482,554,385]	7	hSpCas9	negative selection	810947
233251858	233251881	2	-	26627737	GBM cells	viability after 5 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.3333446995739947	[268]	[123,104]	-5	hSpCas9	negative selection	893257
233263181	233263204	2	+	26627737	GBM cells	viability after 5 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	-0.07743485704966922	[241]	[135,109]	-1	hSpCas9	negative selection	893258
233264015	233264038	2	+	26627737	GBM cells	viability after 5 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	0.5143487278311119	[202]	[172,137]	7	hSpCas9	negative selection	893259
233264910	233264933	2	+	26627737	GBM cells	viability after 5 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	0.03909153293394585	[146]	[72,88]	0	hSpCas9	negative selection	893260
233269995	233270018	2	+	26627737	GBM cells	viability after 5 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.5015783773403008	[269]	[152,256]	7	hSpCas9	negative selection	893261
233274728	233274751	2	-	26627737	GBM cells	viability after 5 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.10550577136899952	[681]	[372,413]	1	hSpCas9	negative selection	893262
233251858	233251881	2	-	26627737	GBM cells	viability after 13 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.014506970468348382	[268]	[165,126]	0	hSpCas9	negative selection	975572
233263181	233263204	2	+	26627737	GBM cells	viability after 13 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	-0.19496454630951338	[241]	[149,85]	-2	hSpCas9	negative selection	975573
233264015	233264038	2	+	26627737	GBM cells	viability after 13 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	0.24206964702824815	[202]	[180,88]	3	hSpCas9	negative selection	975574
233264910	233264933	2	+	26627737	GBM cells	viability after 13 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	0.10077949141133802	[146]	[111,63]	1	hSpCas9	negative selection	975575
233269995	233270018	2	+	26627737	GBM cells	viability after 13 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.6957753489635696	[269]	[185,278]	8	hSpCas9	negative selection	975576
233274728	233274751	2	-	26627737	GBM cells	viability after 13 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.22892609429556776	[681]	[388,469]	3	hSpCas9	negative selection	975577
233251858	233251881	2	-	26627737	GBM cells	viability after 21 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.1532641231155782	[268]	[161,162]	1	hSpCas9	negative selection	1057887
233263181	233263204	2	+	26627737	GBM cells	viability after 21 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	0.12717036781510493	[241]	[164,123]	1	hSpCas9	negative selection	1057888
233264015	233264038	2	+	26627737	GBM cells	viability after 21 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	-0.2773079773708216	[202]	[90,90]	-3	hSpCas9	negative selection	1057889
233264910	233264933	2	+	26627737	GBM cells	viability after 21 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	-0.746549376800125	[146]	[56,38]	-6	hSpCas9	negative selection	1057890
233269995	233270018	2	+	26627737	GBM cells	viability after 21 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.456621064598805	[269]	[205,196]	5	hSpCas9	negative selection	1057891
233274728	233274751	2	-	26627737	GBM cells	viability after 21 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.08845375000791567	[681]	[406,381]	0	hSpCas9	negative selection	1057892
233251858	233251881	2	-	26627737	RPE1	viability after 9 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.39522575713760943	[2211]	[371,725]	-3	hSpCas9	negative selection	1140202
233263181	233263204	2	+	26627737	RPE1	viability after 9 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	-0.08866489988721242	[741]	[162,289]	0	hSpCas9	negative selection	1140203
233264015	233264038	2	+	26627737	RPE1	viability after 9 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	2.019432129038969	[374]	[523,413]	8	hSpCas9	negative selection	1140204
233264910	233264933	2	+	26627737	RPE1	viability after 9 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	0.21075927286072194	[213]	[63,94]	1	hSpCas9	negative selection	1140205
233269995	233270018	2	+	26627737	RPE1	viability after 9 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.5601378114662718	[823]	[399,354]	4	hSpCas9	negative selection	1140206
233274728	233274751	2	-	26627737	RPE1	viability after 9 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.06877995119713565	[2460]	[725,913]	0	hSpCas9	negative selection	1140207
233251858	233251881	2	-	26627737	RPE1	viability after 12 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.799222140350285	[2211]	[307,376]	-5	hSpCas9	negative selection	1222517
233263181	233263204	2	+	26627737	RPE1	viability after 12 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	-0.032045050574341566	[741]	[210,177]	0	hSpCas9	negative selection	1222518
233264015	233264038	2	+	26627737	RPE1	viability after 12 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	1.682030573499183	[374]	[298,348]	8	hSpCas9	negative selection	1222519
233264910	233264933	2	+	26627737	RPE1	viability after 12 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	-0.4530381519492488	[213]	[24,59]	-3	hSpCas9	negative selection	1222520
233269995	233270018	2	+	26627737	RPE1	viability after 12 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.6956126509101442	[823]	[308,410]	4	hSpCas9	negative selection	1222521
233274728	233274751	2	-	26627737	RPE1	viability after 12 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	-0.00929345494053857	[2460]	[586,730]	0	hSpCas9	negative selection	1222522
233251858	233251881	2	-	26627737	RPE1	viability after 15 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.6965239281890656	[2211]	[379,391]	-4	hSpCas9	negative selection	1304832
233263181	233263204	2	+	26627737	RPE1	viability after 15 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	0.006628751766144914	[741]	[302,121]	0	hSpCas9	negative selection	1304833
233264015	233264038	2	+	26627737	RPE1	viability after 15 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	1.1523029478313604	[374]	[219,250]	6	hSpCas9	negative selection	1304834
233264910	233264933	2	+	26627737	RPE1	viability after 15 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	0.06706345199917219	[213]	[39,85]	0	hSpCas9	negative selection	1304835
233269995	233270018	2	+	26627737	RPE1	viability after 15 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.5086253184684423	[823]	[324,337]	3	hSpCas9	negative selection	1304836
233274728	233274751	2	-	26627737	RPE1	viability after 15 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.2027654298882462	[2460]	[760,839]	1	hSpCas9	negative selection	1304837
233251858	233251881	2	-	26627737	RPE1	viability after 18 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.60024881608834	[2211]	[357,431]	-4	hSpCas9	negative selection	1387147
233263181	233263204	2	+	26627737	RPE1	viability after 18 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	0.5577350871119514	[741]	[403,177]	3	hSpCas9	negative selection	1387148
233264015	233264038	2	+	26627737	RPE1	viability after 18 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	1.7387891040200198	[374]	[461,204]	8	hSpCas9	negative selection	1387149
233264910	233264933	2	+	26627737	RPE1	viability after 18 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	-0.6139827589162399	[213]	[29,45]	-4	hSpCas9	negative selection	1387150
233269995	233270018	2	+	26627737	RPE1	viability after 18 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.7677777943979757	[823]	[250,514]	5	hSpCas9	negative selection	1387151
233274728	233274751	2	-	26627737	RPE1	viability after 18 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.32002430862300146	[2460]	[889,763]	2	hSpCas9	negative selection	1387152
233251858	233251881	2	-	26627737	HeLa	viability after 8 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.010232411295496568	[594]	[231,239,300]	0	hSpCas9	negative selection	1469462
233263181	233263204	2	+	26627737	HeLa	viability after 8 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	-0.8094930264704095	[377]	[76,138,63]	-7	hSpCas9	negative selection	1469463
233264015	233264038	2	+	26627737	HeLa	viability after 8 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	1.4411135136204634	[138]	[264,131,120]	8	hSpCas9	negative selection	1469464
233264910	233264933	2	+	26627737	HeLa	viability after 8 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	-1.1389579072627	[237]	[8,80,42]	-8	hSpCas9	negative selection	1469465
233269995	233270018	2	+	26627737	HeLa	viability after 8 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	1.098757308320233	[190]	[164,200,165]	8	hSpCas9	negative selection	1469466
233274728	233274751	2	-	26627737	HeLa	viability after 8 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.33406460920893766	[850]	[625,484,333]	3	hSpCas9	negative selection	1469467
233251858	233251881	2	-	26627737	HeLa	viability after 12 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.7823422745252044	[594]	[65,186,168]	-6	hSpCas9	negative selection	1551777
233263181	233263204	2	+	26627737	HeLa	viability after 12 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	-0.2706616780215132	[377]	[198,86,108]	-2	hSpCas9	negative selection	1551778
233264015	233264038	2	+	26627737	HeLa	viability after 12 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	1.4557482076876163	[138]	[282,141,52]	8	hSpCas9	negative selection	1551779
233264910	233264933	2	+	26627737	HeLa	viability after 12 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	0.16650537535362941	[237]	[183,84,66]	1	hSpCas9	negative selection	1551780
233269995	233270018	2	+	26627737	HeLa	viability after 12 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	1.312025845031961	[190]	[85,221,273]	8	hSpCas9	negative selection	1551781
233274728	233274751	2	-	26627737	HeLa	viability after 12 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.5671820147000837	[850]	[778,423,377]	5	hSpCas9	negative selection	1551782
233251858	233251881	2	-	26627737	HeLa	viability after 15 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.2816068801653233	[594]	[211,145,242]	-2	hSpCas9	negative selection	1634092
233263181	233263204	2	+	26627737	HeLa	viability after 15 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	-0.27432282601353336	[377]	[182,118,74]	-2	hSpCas9	negative selection	1634093
233264015	233264038	2	+	26627737	HeLa	viability after 15 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	1.6743550383068269	[138]	[253,104,181]	9	hSpCas9	negative selection	1634094
233264910	233264933	2	+	26627737	HeLa	viability after 15 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	-0.5834188895084206	[237]	[47,83,61]	-5	hSpCas9	negative selection	1634095
233269995	233270018	2	+	26627737	HeLa	viability after 15 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	1.2638878669065026	[190]	[261,112,183]	8	hSpCas9	negative selection	1634096
233274728	233274751	2	-	26627737	HeLa	viability after 15 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.4822400240944287	[850]	[516,660,255]	4	hSpCas9	negative selection	1634097
233251858	233251881	2	-	26627737	HeLa	viability after 18 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.3032007076792719	[594]	[137,118,242]	-3	hSpCas9	negative selection	1716407
233263181	233263204	2	+	26627737	HeLa	viability after 18 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	-0.2512794672905942	[377]	[127,96,74]	-2	hSpCas9	negative selection	1716408
233264015	233264038	2	+	26627737	HeLa	viability after 18 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	1.6932035559543985	[138]	[170,91,181]	9	hSpCas9	negative selection	1716409
233264910	233264933	2	+	26627737	HeLa	viability after 18 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	-0.5794072400217566	[237]	[36,63,61]	-5	hSpCas9	negative selection	1716410
233269995	233270018	2	+	26627737	HeLa	viability after 18 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	1.2621110622860574	[190]	[170,98,183]	8	hSpCas9	negative selection	1716411
233274728	233274751	2	-	26627737	HeLa	viability after 18 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.4954358482083068	[850]	[358,542,255]	4	hSpCas9	negative selection	1716412
233251858	233251881	2	-	26627737	HCT116	viability after 6 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.7272300621828909	[572]	[210,114]	4	hSpCas9	negative selection	1798722
233263181	233263204	2	+	26627737	HCT116	viability after 6 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	1.1445347345756387	[556]	[25,285]	6	hSpCas9	negative selection	1798723
233264015	233264038	2	+	26627737	HCT116	viability after 6 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	0.8341644657143212	[297]	[20,117]	4	hSpCas9	negative selection	1798724
233264910	233264933	2	+	26627737	HCT116	viability after 6 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	0.9577278545362371	[154]	[85,25]	5	hSpCas9	negative selection	1798725
233269995	233270018	2	+	26627737	HCT116	viability after 6 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	-0.8402994332759661	[578]	[84,31]	-5	hSpCas9	negative selection	1798726
233274728	233274751	2	-	26627737	HCT116	viability after 6 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.7128643473525251	[1339]	[401,313]	4	hSpCas9	negative selection	1798727
233251858	233251881	2	-	26627737	HCT116	viability after 8 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.16050445182443046	[384]	[163,217,186]	-2	hSpCas9	negative selection	1881037
233263181	233263204	2	+	26627737	HCT116	viability after 8 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	0.3435607174957276	[232]	[168,169,149]	4	hSpCas9	negative selection	1881038
233264015	233264038	2	+	26627737	HCT116	viability after 8 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	-0.42900385371692784	[426]	[228,181,114]	-5	hSpCas9	negative selection	1881039
233264910	233264933	2	+	26627737	HCT116	viability after 8 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	0.6620561855844502	[84]	[93,79,48]	6	hSpCas9	negative selection	1881040
233269995	233270018	2	+	26627737	HCT116	viability after 8 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	1.0273592782759988	[194]	[174,240,239]	8	hSpCas9	negative selection	1881041
233274728	233274751	2	-	26627737	HCT116	viability after 8 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.14392195298089905	[696]	[485,349,437]	1	hSpCas9	negative selection	1881042
233251858	233251881	2	-	26627737	HCT116	viability after 9 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	1.0118726108855705	[572]	[188,402]	7	hSpCas9	negative selection	1963352
233263181	233263204	2	+	26627737	HCT116	viability after 9 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	1.0222913417620503	[556]	[305,298]	7	hSpCas9	negative selection	1963353
233264015	233264038	2	+	26627737	HCT116	viability after 9 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	1.209100670306365	[297]	[169,194]	7	hSpCas9	negative selection	1963354
233264910	233264933	2	+	26627737	HCT116	viability after 9 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	1.8365613162089771	[154]	[77,202]	9	hSpCas9	negative selection	1963355
233269995	233270018	2	+	26627737	HCT116	viability after 9 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	-0.7385914195735777	[578]	[114,74]	-5	hSpCas9	negative selection	1963356
233274728	233274751	2	-	26627737	HCT116	viability after 9 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.03629000992204778	[1339]	[257,452]	0	hSpCas9	negative selection	1963357
233251858	233251881	2	-	26627737	HCT116	viability after 12 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.6393656579682244	[384]	[115,133,140]	-6	hSpCas9	negative selection	2045667
233263181	233263204	2	+	26627737	HCT116	viability after 12 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	0.08251067613633728	[232]	[55,152,186]	0	hSpCas9	negative selection	2045668
233264015	233264038	2	+	26627737	HCT116	viability after 12 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	-0.7873720116989843	[426]	[124,150,114]	-7	hSpCas9	negative selection	2045669
233264910	233264933	2	+	26627737	HCT116	viability after 12 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	0.5434269494076487	[84]	[52,90,52]	5	hSpCas9	negative selection	2045670
233269995	233270018	2	+	26627737	HCT116	viability after 12 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.8460874997392666	[194]	[173,202,176]	7	hSpCas9	negative selection	2045671
233274728	233274751	2	-	26627737	HCT116	viability after 12 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.0989536042784187	[696]	[428,405,338]	1	hSpCas9	negative selection	2045672
233251858	233251881	2	-	26627737	HCT116	viability after 15 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.4061148147057114	[384]	[164,139,194]	-4	hSpCas9	negative selection	2127982
233263181	233263204	2	+	26627737	HCT116	viability after 15 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	0.31031442506890444	[232]	[145,154,193]	3	hSpCas9	negative selection	2127983
233264015	233264038	2	+	26627737	HCT116	viability after 15 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	-0.6302375757181968	[426]	[173,211,91]	-6	hSpCas9	negative selection	2127984
233264910	233264933	2	+	26627737	HCT116	viability after 15 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	-0.028909696651862715	[84]	[30,104,5]	0	hSpCas9	negative selection	2127985
233269995	233270018	2	+	26627737	HCT116	viability after 15 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.8717537958640469	[194]	[254,254,111]	7	hSpCas9	negative selection	2127986
233274728	233274751	2	-	26627737	HCT116	viability after 15 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.2522673302163332	[696]	[483,371,573]	2	hSpCas9	negative selection	2127987
233251858	233251881	2	-	26627737	HCT116	viability after 18 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.9602337163111643	[384]	[88,46,156]	-7	hSpCas9	negative selection	2210297
233263181	233263204	2	+	26627737	HCT116	viability after 18 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	0.20729774892586722	[232]	[71,197,114]	1	hSpCas9	negative selection	2210298
233264015	233264038	2	+	26627737	HCT116	viability after 18 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	-0.39349793629107604	[426]	[77,244,141]	-4	hSpCas9	negative selection	2210299
233264910	233264933	2	+	26627737	HCT116	viability after 18 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	0.1299819859711724	[84]	[30,66,34]	1	hSpCas9	negative selection	2210300
233269995	233270018	2	+	26627737	HCT116	viability after 18 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	1.2751882509092134	[194]	[209,239,233]	8	hSpCas9	negative selection	2210301
233274728	233274751	2	-	26627737	HCT116	viability after 18 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.03408712173738815	[696]	[323,319,394]	0	hSpCas9	negative selection	2210302
233263209	233263233	2	+	24717434	HeLa	essential genes for diphteria toxin toxicity	ACTGAATTACACAAGAAACGTGGG	ATG16L1	ENSG00000085978	8.160764000831161	[1587,1309,1587]	[0,506,0]	8	hSpCas9	positive selection	2380548
233263209	233263233	2	+	24717434	HeLa	essential genes for diphteria toxin toxicity	ACTGAATTACACAAGAAACGTGGG	ATG16L1	ENSG00000085978	8.160764000831161	[1587,1309,1587]	[0,506,0]	8	hSpCas9	positive selection	2380549
233264016	233264038	2	+	24717434	HeLa	essential genes for diphteria toxin toxicity	AATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	0.21835113081376367	[2246,2197,2054]	[0,0,0]	0	hSpCas9	positive selection	2380550
233264016	233264038	2	+	24717434	HeLa	essential genes for diphteria toxin toxicity	AATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	0.21835113081376367	[2246,2197,2054]	[0,0,0]	0	hSpCas9	positive selection	2380551
233264011	233264034	2	+	24717434	HeLa	essential genes for diphteria toxin toxicity	ACCTGAATAACCAAATGCAGCGG	ATG16L1	ENSG00000085978	0.6999548333868605	[4304,3237,3359]	[0,0,4]	2	hSpCas9	positive selection	2380552
233264011	233264034	2	+	24717434	HeLa	essential genes for diphteria toxin toxicity	ACCTGAATAACCAAATGCAGCGG	ATG16L1	ENSG00000085978	0.6999548333868605	[4304,3237,3359]	[0,0,4]	2	hSpCas9	positive selection	2380553
233263209	233263233	2	+	24717434	HeLa	essential genes for PA/LFnDTA toxicity	ACTGAATTACACAAGAAACGTGGG	ATG16L1	ENSG00000085978	0.754453382929426	[1587,1309,1587]	[0,0,0]	2	hSpCas9	positive selection	2381658
233263209	233263233	2	+	24717434	HeLa	essential genes for PA/LFnDTA toxicity	ACTGAATTACACAAGAAACGTGGG	ATG16L1	ENSG00000085978	0.754453382929426	[1587,1309,1587]	[0,0,0]	2	hSpCas9	positive selection	2381659
233264016	233264038	2	+	24717434	HeLa	essential genes for PA/LFnDTA toxicity	AATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	0.2179960404616596	[2246,2197,2054]	[0,0,0]	0	hSpCas9	positive selection	2381660
233264016	233264038	2	+	24717434	HeLa	essential genes for PA/LFnDTA toxicity	AATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	0.2179960404616596	[2246,2197,2054]	[0,0,0]	0	hSpCas9	positive selection	2381661
233264011	233264034	2	+	24717434	HeLa	essential genes for PA/LFnDTA toxicity	ACCTGAATAACCAAATGCAGCGG	ATG16L1	ENSG00000085978	2.936854515557411	[4304,3237,3359]	[0,30,0]	5	hSpCas9	positive selection	2381662
233264011	233264034	2	+	24717434	HeLa	essential genes for PA/LFnDTA toxicity	ACCTGAATAACCAAATGCAGCGG	ATG16L1	ENSG00000085978	2.936854515557411	[4304,3237,3359]	[0,30,0]	5	hSpCas9	positive selection	2381663
233267099	233267122	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGCACTTTGGGAGGCCAAGGAAG	ATG16L1	ENSG00000085978	0.21234444010885142	[57,122]	[21,23]	1	dCas9-VP64	positive selection	2422432
233267099	233267122	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGCACTTTGGGAGGCCAAGGAAG	ATG16L1	ENSG00000281089	0.21234444010885142	[57,122]	[21,23]	1	dCas9-VP64	positive selection	2422433
233288330	233288353	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGAGTGCAGTGGCATGATCTGGG	ATG16L1	ENSG00000085978	2.493462356292235	[8,24]	[27,14]	8	dCas9-VP64	positive selection	2433653
233288330	233288353	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGAGTGCAGTGGCATGATCTGGG	ATG16L1	ENSG00000281089	2.493462356292235	[8,24]	[27,14]	8	dCas9-VP64	positive selection	2433654
233251374	233251397	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	AAATAAAAGTGGGGGGAGACAGG	ATG16L1	ENSG00000281089	2.0913409380942185	[1,1]	[2,0]	7	dCas9-VP64	positive selection	2449298
233251374	233251397	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	AAATAAAAGTGGGGGGAGACAGG	ATG16L1	ENSG00000085978	2.0913409380942185	[1,1]	[2,0]	7	dCas9-VP64	positive selection	2449299
233251441	233251464	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGTAAGCAGTCAGGCGGAAACGG	ATG16L1	ENSG00000281089	2.651121342639623	[110,29]	[6,192]	8	dCas9-VP64	positive selection	2449300
233251441	233251464	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGTAAGCAGTCAGGCGGAAACGG	ATG16L1	ENSG00000085978	2.651121342639623	[110,29]	[6,192]	8	dCas9-VP64	positive selection	2449301
233251475	233251498	2	-	25494202	A375	resistance to PLX-4720 (puromycin)	CCCAGCGCCGGGCGGGAAGGAGG	ATG16L1	ENSG00000085978	-0.3472883657409658	[7,32]	[1,3]	-2	dCas9-VP64	positive selection	2449302
233251475	233251498	CHR_HG2232_PATCH	-	25494202	A375	resistance to PLX-4720 (puromycin)	CCCAGCGCCGGGCGGGAAGGAGG	ATG16L1	ENSG00000281089	-0.3472883657409658	[7,32]	[1,3]	-2	dCas9-VP64	positive selection	2449303
233283624	233283647	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	CACTGCAACCTCCGCCTTCTGGG	ATG16L1	ENSG00000085978	-1.1299099924366551	[152,73]	[14,5]	-6	dCas9-VP64	positive selection	2465396
233283624	233283647	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	CACTGCAACCTCCGCCTTCTGGG	ATG16L1	ENSG00000281089	-1.1299099924366551	[152,73]	[14,5]	-6	dCas9-VP64	positive selection	2465397
233244094	233244117	2	-	25494202	A375	resistance to PLX-4720 (puromycin)	GCCTCGGCCTTCTGAGTAGCTGG	ATG16L1	ENSG00000085978	-0.2916235343893049	[91,202]	[20,31]	-1	dCas9-VP64	positive selection	2471111
233244094	233244117	CHR_HG2232_PATCH	-	25494202	A375	resistance to PLX-4720 (puromycin)	GCCTCGGCCTTCTGAGTAGCTGG	ATG16L1	ENSG00000281089	-0.2916235343893049	[91,202]	[20,31]	-1	dCas9-VP64	positive selection	2471112
233266202	233266225	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGCGGAGGCGGAGGCGGAGGCGG	ATG16L1	ENSG00000085978	4.624516986046515	[0,2]	[2,23]	9	dCas9-VP64	positive selection	2475027
233266202	233266225	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGCGGAGGCGGAGGCGGAGGCGG	ATG16L1	ENSG00000281089	4.624516986046515	[0,2]	[2,23]	9	dCas9-VP64	positive selection	2475028
233266208	233266231	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGCGGAGGCGGAGGCGGAGGCGG	ATG16L1	ENSG00000085978	4.624516986046515	[0,2]	[2,23]	9	dCas9-VP64	positive selection	2475040
233266208	233266231	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGCGGAGGCGGAGGCGGAGGCGG	ATG16L1	ENSG00000281089	4.624516986046515	[0,2]	[2,23]	9	dCas9-VP64	positive selection	2475041
233255011	233255034	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCGCCCAGGCTGGAGTGCAGTGG	ATG16L1	ENSG00000085978	0.5070772209909733	[97,61]	[39,7]	2	dCas9-VP64	positive selection	2477718
233255011	233255034	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCGCCCAGGCTGGAGTGCAGTGG	ATG16L1	ENSG00000281089	0.5070772209909733	[97,61]	[39,7]	2	dCas9-VP64	positive selection	2477719
233267099	233267122	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGCACTTTGGGAGGCCAAGGAAG	ATG16L1	ENSG00000085978	-0.9329704115466368	[100,219]	[26,25]	-8	dCas9-VP64	positive selection	2517687
233267099	233267122	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGCACTTTGGGAGGCCAAGGAAG	ATG16L1	ENSG00000281089	-0.9329704115466368	[100,219]	[26,25]	-8	dCas9-VP64	positive selection	2517688
233288330	233288353	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGAGTGCAGTGGCATGATCTGGG	ATG16L1	ENSG00000085978	-0.3977265325465724	[58,186]	[26,32]	-4	dCas9-VP64	positive selection	2528908
233288330	233288353	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGAGTGCAGTGGCATGATCTGGG	ATG16L1	ENSG00000281089	-0.3977265325465724	[58,186]	[26,32]	-4	dCas9-VP64	positive selection	2528909
233251374	233251397	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	AAATAAAAGTGGGGGGAGACAGG	ATG16L1	ENSG00000281089	-0.26377657083823536	[25,30]	[6,7]	-2	dCas9-VP64	positive selection	2544553
233251374	233251397	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	AAATAAAAGTGGGGGGAGACAGG	ATG16L1	ENSG00000085978	-0.26377657083823536	[25,30]	[6,7]	-2	dCas9-VP64	positive selection	2544554
233251441	233251464	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGTAAGCAGTCAGGCGGAAACGG	ATG16L1	ENSG00000281089	-0.5365622396262557	[139,120]	[40,17]	-5	dCas9-VP64	positive selection	2544555
233251441	233251464	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGTAAGCAGTCAGGCGGAAACGG	ATG16L1	ENSG00000085978	-0.5365622396262557	[139,120]	[40,17]	-5	dCas9-VP64	positive selection	2544556
233251475	233251498	2	-	25494202	A375	resistance to PLX-4720 (zeocin)	CCCAGCGCCGGGCGGGAAGGAGG	ATG16L1	ENSG00000085978	0.6251807133431164	[14,83]	[4,41]	4	dCas9-VP64	positive selection	2544557
233251475	233251498	CHR_HG2232_PATCH	-	25494202	A375	resistance to PLX-4720 (zeocin)	CCCAGCGCCGGGCGGGAAGGAGG	ATG16L1	ENSG00000281089	0.6251807133431164	[14,83]	[4,41]	4	dCas9-VP64	positive selection	2544558
233283624	233283647	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	CACTGCAACCTCCGCCTTCTGGG	ATG16L1	ENSG00000085978	1.9293870201515944	[173,114]	[70,283]	8	dCas9-VP64	positive selection	2560651
233283624	233283647	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	CACTGCAACCTCCGCCTTCTGGG	ATG16L1	ENSG00000281089	1.9293870201515944	[173,114]	[70,283]	8	dCas9-VP64	positive selection	2560652
233244094	233244117	2	-	25494202	A375	resistance to PLX-4720 (zeocin)	GCCTCGGCCTTCTGAGTAGCTGG	ATG16L1	ENSG00000085978	0.3546757930758111	[148,126]	[57,56]	3	dCas9-VP64	positive selection	2566366
233244094	233244117	CHR_HG2232_PATCH	-	25494202	A375	resistance to PLX-4720 (zeocin)	GCCTCGGCCTTCTGAGTAGCTGG	ATG16L1	ENSG00000281089	0.3546757930758111	[148,126]	[57,56]	3	dCas9-VP64	positive selection	2566367
233266202	233266225	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGCGGAGGCGGAGGCGGAGGCGG	ATG16L1	ENSG00000085978	0.19922026917770452	[38,4]	[7,7]	1	dCas9-VP64	positive selection	2570282
233266202	233266225	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGCGGAGGCGGAGGCGGAGGCGG	ATG16L1	ENSG00000281089	0.19922026917770452	[38,4]	[7,7]	1	dCas9-VP64	positive selection	2570283
233266208	233266231	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGCGGAGGCGGAGGCGGAGGCGG	ATG16L1	ENSG00000085978	0.19922026917770452	[38,4]	[7,7]	1	dCas9-VP64	positive selection	2570295
233266208	233266231	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGCGGAGGCGGAGGCGGAGGCGG	ATG16L1	ENSG00000281089	0.19922026917770452	[38,4]	[7,7]	1	dCas9-VP64	positive selection	2570296
233255011	233255034	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCGCCCAGGCTGGAGTGCAGTGG	ATG16L1	ENSG00000085978	-0.06949214303462026	[365,454]	[80,170]	0	dCas9-VP64	positive selection	2572973
233255011	233255034	CHR_HG2232_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCGCCCAGGCTGGAGTGCAGTGG	ATG16L1	ENSG00000281089	-0.06949214303462026	[365,454]	[80,170]	0	dCas9-VP64	positive selection	2572974
233264012	233264035	2	-	27260157	DLD1	viability	TCCGCTGCATTTGGTTATTCAGG	ATG16L1	ENSG00000085978	0.738812839812692	[]	[]	8	hSpCas9	negative selection	2574102
233251883	233251906	2	+	27260157	DLD1	viability	AGCAACTGAGGCGCCGGGACCGG	ATG16L1	ENSG00000085978	0.289358938281804	[]	[]	4	hSpCas9	negative selection	2577849
233264922	233264945	2	-	27260157	DLD1	viability	GGTCTAGGCACTCCGTCTCCAGG	ATG16L1	ENSG00000085978	-1.04814383776637	[]	[]	-7	hSpCas9	negative selection	2580601
233277603	233277626	2	+	27260157	DLD1	viability	CAGTCCAGGTTCCCGGTTACTGG	ATG16L1	ENSG00000085978	-0.0183765870634708	[]	[]	0	hSpCas9	negative selection	2580895
233289898	233289921	2	-	27260157	DLD1	viability	CAATCCGCGCATTGTCCAGCAGG	ATG16L1	ENSG00000085978	0.606799425842952	[]	[]	8	hSpCas9	negative selection	2583110
233256136	233256159	2	+	27260157	DLD1	viability	AGTGTTGGCCCAGAAACTACAGG	ATG16L1	ENSG00000085978	0.238818375101754	[]	[]	4	hSpCas9	negative selection	2586912
233289905	233289928	2	+	27260157	DLD1	viability	GACAATGCGCGGATTGTCTCAGG	ATG16L1	ENSG00000085978	-0.079135892151353	[]	[]	0	hSpCas9	negative selection	2587535
233270051	233270074	2	-	27260157	DLD1	viability	ACTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.388358900844529	[]	[]	4	hSpCas9	negative selection	2604511
233277626	233277649	2	+	27260157	DLD1	viability	CCACTGGAGGCATGGACCGCAGG	ATG16L1	ENSG00000085978	0.693754012976788	[]	[]	8	hSpCas9	negative selection	2607352
233263129	233263152	2	+	27260157	DLD1	viability	GTCCCGGACATGATGGCACATGG	ATG16L1	ENSG00000085978	0.19083906875172	[]	[]	3	hSpCas9	negative selection	2609186
233251872	233251895	2	-	27260157	DLD1	viability	GCCTCAGTTGCTCCGAGATGTGG	ATG16L1	ENSG00000085978	-0.0257998227140679	[]	[]	0	hSpCas9	negative selection	2614809
233293253	233293276	2	+	27260157	DLD1	viability	TAGCCCTGATGGCAGTTACGTGG	ATG16L1	ENSG00000085978	-0.271865389222576	[]	[]	-2	hSpCas9	negative selection	2614881
233289933	233289956	2	+	27260157	DLD1	viability	ACGACCGGACTCTCAAACTCTGG	ATG16L1	ENSG00000085978	0.883858570846138	[]	[]	9	hSpCas9	negative selection	2615836
233273722	233273745	2	+	27260157	DLD1	viability	AAGCGACTCTCGCAGCCTGCTGG	ATG16L1	ENSG00000085978	-0.254142505931354	[]	[]	-2	hSpCas9	negative selection	2617666
233274703	233274726	2	-	27260157	DLD1	viability	GAGTATCCACATTGTCCTGGGGG	ATG16L1	ENSG00000085978	0.696447719140281	[]	[]	8	hSpCas9	negative selection	2617694
233264904	233264927	2	+	27260157	DLD1	viability	TTTGCAGACTATCTCTGACCTGG	ATG16L1	ENSG00000085978	-0.94218447697598	[]	[]	-6	hSpCas9	negative selection	2620876
233277589	233277612	2	+	27260157	DLD1	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.091317419009548	[]	[]	3	hSpCas9	negative selection	2621930
233277642	233277665	2	-	27260157	DLD1	viability	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	-0.573322689951047	[]	[]	-5	hSpCas9	negative selection	2642549
233292395	233292418	2	+	27260157	DLD1	viability	GGTTCAAGTGCGGCTCTGACTGG	ATG16L1	ENSG00000085978	0.512362367182498	[]	[]	8	hSpCas9	negative selection	2644839
233292141	233292164	2	+	27260157	DLD1	viability	GTTCGAGAGATGGAGCTGTTGGG	ATG16L1	ENSG00000085978	0.904760649924973	[]	[]	9	hSpCas9	negative selection	2646746
233264012	233264035	2	-	27260157	HT1080	viability	TCCGCTGCATTTGGTTATTCAGG	ATG16L1	ENSG00000085978	-0.580124526171753	[]	[]	-7	hSpCas9	negative selection	2650232
233251883	233251906	2	+	27260157	HT1080	viability	AGCAACTGAGGCGCCGGGACCGG	ATG16L1	ENSG00000085978	0.833196942360235	[]	[]	7	hSpCas9	negative selection	2653979
233264922	233264945	2	-	27260157	HT1080	viability	GGTCTAGGCACTCCGTCTCCAGG	ATG16L1	ENSG00000085978	-0.67649067424957	[]	[]	-8	hSpCas9	negative selection	2656731
233277603	233277626	2	+	27260157	HT1080	viability	CAGTCCAGGTTCCCGGTTACTGG	ATG16L1	ENSG00000085978	0.306206319438202	[]	[]	3	hSpCas9	negative selection	2657025
233289898	233289921	2	-	27260157	HT1080	viability	CAATCCGCGCATTGTCCAGCAGG	ATG16L1	ENSG00000085978	0.807474504180244	[]	[]	7	hSpCas9	negative selection	2659240
233256136	233256159	2	+	27260157	HT1080	viability	AGTGTTGGCCCAGAAACTACAGG	ATG16L1	ENSG00000085978	-0.310512450699005	[]	[]	-7	hSpCas9	negative selection	2663042
233289905	233289928	2	+	27260157	HT1080	viability	GACAATGCGCGGATTGTCTCAGG	ATG16L1	ENSG00000085978	0.262508336144123	[]	[]	2	hSpCas9	negative selection	2663665
233270051	233270074	2	-	27260157	HT1080	viability	ACTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	-0.000742020514861959	[]	[]	0	hSpCas9	negative selection	2680641
233277626	233277649	2	+	27260157	HT1080	viability	CCACTGGAGGCATGGACCGCAGG	ATG16L1	ENSG00000085978	0.724545007741288	[]	[]	6	hSpCas9	negative selection	2683482
233263129	233263152	2	+	27260157	HT1080	viability	GTCCCGGACATGATGGCACATGG	ATG16L1	ENSG00000085978	0.264297030561375	[]	[]	2	hSpCas9	negative selection	2685316
233251872	233251895	2	-	27260157	HT1080	viability	GCCTCAGTTGCTCCGAGATGTGG	ATG16L1	ENSG00000085978	-0.906294070034734	[]	[]	-8	hSpCas9	negative selection	2690939
233293253	233293276	2	+	27260157	HT1080	viability	TAGCCCTGATGGCAGTTACGTGG	ATG16L1	ENSG00000085978	0.668340156279814	[]	[]	6	hSpCas9	negative selection	2691011
233289933	233289956	2	+	27260157	HT1080	viability	ACGACCGGACTCTCAAACTCTGG	ATG16L1	ENSG00000085978	1.19899624317273	[]	[]	8	hSpCas9	negative selection	2691966
233273722	233273745	2	+	27260157	HT1080	viability	AAGCGACTCTCGCAGCCTGCTGG	ATG16L1	ENSG00000085978	0.51036766110093	[]	[]	4	hSpCas9	negative selection	2693796
233274703	233274726	2	-	27260157	HT1080	viability	GAGTATCCACATTGTCCTGGGGG	ATG16L1	ENSG00000085978	0.212493794378508	[]	[]	2	hSpCas9	negative selection	2693824
233264904	233264927	2	+	27260157	HT1080	viability	TTTGCAGACTATCTCTGACCTGG	ATG16L1	ENSG00000085978	-1.42154669546161	[]	[]	-9	hSpCas9	negative selection	2697006
233277589	233277612	2	+	27260157	HT1080	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.292546628298702	[]	[]	2	hSpCas9	negative selection	2698060
233277642	233277665	2	-	27260157	HT1080	viability	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	-1.03146302730315	[]	[]	-8	hSpCas9	negative selection	2718679
233292395	233292418	2	+	27260157	HT1080	viability	GGTTCAAGTGCGGCTCTGACTGG	ATG16L1	ENSG00000085978	0.405810372102429	[]	[]	3	hSpCas9	negative selection	2720969
233292141	233292164	2	+	27260157	HT1080	viability	GTTCGAGAGATGGAGCTGTTGGG	ATG16L1	ENSG00000085978	0.715270590576231	[]	[]	6	hSpCas9	negative selection	2722876
233264012	233264035	2	-	27260157	MKN45	viability	TCCGCTGCATTTGGTTATTCAGG	ATG16L1	ENSG00000085978	-0.487616707678475	[]	[]	-6	hSpCas9	negative selection	2726362
233251883	233251906	2	+	27260157	MKN45	viability	AGCAACTGAGGCGCCGGGACCGG	ATG16L1	ENSG00000085978	1.3811178707079	[]	[]	9	hSpCas9	negative selection	2730109
233264922	233264945	2	-	27260157	MKN45	viability	GGTCTAGGCACTCCGTCTCCAGG	ATG16L1	ENSG00000085978	-0.159433429783836	[]	[]	0	hSpCas9	negative selection	2732861
233277603	233277626	2	+	27260157	MKN45	viability	CAGTCCAGGTTCCCGGTTACTGG	ATG16L1	ENSG00000085978	0.23489171268772	[]	[]	5	hSpCas9	negative selection	2733155
233289898	233289921	2	-	27260157	MKN45	viability	CAATCCGCGCATTGTCCAGCAGG	ATG16L1	ENSG00000085978	1.28274491969583	[]	[]	9	hSpCas9	negative selection	2735370
233256136	233256159	2	+	27260157	MKN45	viability	AGTGTTGGCCCAGAAACTACAGG	ATG16L1	ENSG00000085978	0.0634088447615565	[]	[]	0	hSpCas9	negative selection	2739172
233289905	233289928	2	+	27260157	MKN45	viability	GACAATGCGCGGATTGTCTCAGG	ATG16L1	ENSG00000085978	-0.224089453078584	[]	[]	-1	hSpCas9	negative selection	2739795
233270051	233270074	2	-	27260157	MKN45	viability	ACTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.495483536371687	[]	[]	6	hSpCas9	negative selection	2756771
233277626	233277649	2	+	27260157	MKN45	viability	CCACTGGAGGCATGGACCGCAGG	ATG16L1	ENSG00000085978	1.15450004665629	[]	[]	8	hSpCas9	negative selection	2759612
233263129	233263152	2	+	27260157	MKN45	viability	GTCCCGGACATGATGGCACATGG	ATG16L1	ENSG00000085978	0.971715421426669	[]	[]	8	hSpCas9	negative selection	2761446
233251872	233251895	2	-	27260157	MKN45	viability	GCCTCAGTTGCTCCGAGATGTGG	ATG16L1	ENSG00000085978	-0.134908688324587	[]	[]	0	hSpCas9	negative selection	2767069
233293253	233293276	2	+	27260157	MKN45	viability	TAGCCCTGATGGCAGTTACGTGG	ATG16L1	ENSG00000085978	0.462576606361653	[]	[]	6	hSpCas9	negative selection	2767141
233289933	233289956	2	+	27260157	MKN45	viability	ACGACCGGACTCTCAAACTCTGG	ATG16L1	ENSG00000085978	1.08621649760071	[]	[]	8	hSpCas9	negative selection	2768096
233273722	233273745	2	+	27260157	MKN45	viability	AAGCGACTCTCGCAGCCTGCTGG	ATG16L1	ENSG00000085978	0.666124120672201	[]	[]	7	hSpCas9	negative selection	2769926
233274703	233274726	2	-	27260157	MKN45	viability	GAGTATCCACATTGTCCTGGGGG	ATG16L1	ENSG00000085978	-0.236438544852522	[]	[]	-1	hSpCas9	negative selection	2769954
233264904	233264927	2	+	27260157	MKN45	viability	TTTGCAGACTATCTCTGACCTGG	ATG16L1	ENSG00000085978	-0.695382060118464	[]	[]	-7	hSpCas9	negative selection	2773136
233277589	233277612	2	+	27260157	MKN45	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.714579351884199	[]	[]	7	hSpCas9	negative selection	2774190
233277642	233277665	2	-	27260157	MKN45	viability	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	-0.755080570025182	[]	[]	-7	hSpCas9	negative selection	2794809
233292395	233292418	2	+	27260157	MKN45	viability	GGTTCAAGTGCGGCTCTGACTGG	ATG16L1	ENSG00000085978	0.929874298089008	[]	[]	8	hSpCas9	negative selection	2797099
233292141	233292164	2	+	27260157	MKN45	viability	GTTCGAGAGATGGAGCTGTTGGG	ATG16L1	ENSG00000085978	0.987951088498584	[]	[]	8	hSpCas9	negative selection	2799006
233264012	233264035	2	-	27260157	RKO	viability	TCCGCTGCATTTGGTTATTCAGG	ATG16L1	ENSG00000085978	-0.307324796384867	[]	[]	-6	hSpCas9	negative selection	2802492
233251883	233251906	2	+	27260157	RKO	viability	AGCAACTGAGGCGCCGGGACCGG	ATG16L1	ENSG00000085978	0.813049874917293	[]	[]	8	hSpCas9	negative selection	2806239
233264922	233264945	2	-	27260157	RKO	viability	GGTCTAGGCACTCCGTCTCCAGG	ATG16L1	ENSG00000085978	-1.37700994319478	[]	[]	-8	hSpCas9	negative selection	2808991
233277603	233277626	2	+	27260157	RKO	viability	CAGTCCAGGTTCCCGGTTACTGG	ATG16L1	ENSG00000085978	0.474392479891986	[]	[]	2	hSpCas9	negative selection	2809285
233289898	233289921	2	-	27260157	RKO	viability	CAATCCGCGCATTGTCCAGCAGG	ATG16L1	ENSG00000085978	0.957705568101024	[]	[]	8	hSpCas9	negative selection	2811500
233256136	233256159	2	+	27260157	RKO	viability	AGTGTTGGCCCAGAAACTACAGG	ATG16L1	ENSG00000085978	-0.243285057579201	[]	[]	-1	hSpCas9	negative selection	2815302
233289905	233289928	2	+	27260157	RKO	viability	GACAATGCGCGGATTGTCTCAGG	ATG16L1	ENSG00000085978	-0.652471096805991	[]	[]	-7	hSpCas9	negative selection	2815925
233270051	233270074	2	-	27260157	RKO	viability	ACTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.866399937561176	[]	[]	8	hSpCas9	negative selection	2832901
233277626	233277649	2	+	27260157	RKO	viability	CCACTGGAGGCATGGACCGCAGG	ATG16L1	ENSG00000085978	1.07909388017969	[]	[]	9	hSpCas9	negative selection	2835742
233263129	233263152	2	+	27260157	RKO	viability	GTCCCGGACATGATGGCACATGG	ATG16L1	ENSG00000085978	0.637224743554285	[]	[]	3	hSpCas9	negative selection	2837576
233251872	233251895	2	-	27260157	RKO	viability	GCCTCAGTTGCTCCGAGATGTGG	ATG16L1	ENSG00000085978	-0.668340081797066	[]	[]	-7	hSpCas9	negative selection	2843199
233293253	233293276	2	+	27260157	RKO	viability	TAGCCCTGATGGCAGTTACGTGG	ATG16L1	ENSG00000085978	0.209930523594101	[]	[]	1	hSpCas9	negative selection	2843271
233289933	233289956	2	+	27260157	RKO	viability	ACGACCGGACTCTCAAACTCTGG	ATG16L1	ENSG00000085978	0.986848346936748	[]	[]	9	hSpCas9	negative selection	2844226
233273722	233273745	2	+	27260157	RKO	viability	AAGCGACTCTCGCAGCCTGCTGG	ATG16L1	ENSG00000085978	0.637637987438712	[]	[]	3	hSpCas9	negative selection	2846056
233274703	233274726	2	-	27260157	RKO	viability	GAGTATCCACATTGTCCTGGGGG	ATG16L1	ENSG00000085978	0.784945162351276	[]	[]	8	hSpCas9	negative selection	2846084
233264904	233264927	2	+	27260157	RKO	viability	TTTGCAGACTATCTCTGACCTGG	ATG16L1	ENSG00000085978	-0.909618566461201	[]	[]	-8	hSpCas9	negative selection	2849266
233277589	233277612	2	+	27260157	RKO	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.82783888400878	[]	[]	8	hSpCas9	negative selection	2850320
233277642	233277665	2	-	27260157	RKO	viability	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	-0.0175248491364007	[]	[]	0	hSpCas9	negative selection	2870939
233292395	233292418	2	+	27260157	RKO	viability	GGTTCAAGTGCGGCTCTGACTGG	ATG16L1	ENSG00000085978	0.742158814860725	[]	[]	8	hSpCas9	negative selection	2873229
233292141	233292164	2	+	27260157	RKO	viability	GTTCGAGAGATGGAGCTGTTGGG	ATG16L1	ENSG00000085978	1.22156325056804	[]	[]	9	hSpCas9	negative selection	2875136
233264012	233264035	2	-	27260157	SF268	viability	TCCGCTGCATTTGGTTATTCAGG	ATG16L1	ENSG00000085978	-0.882319413454883	[]	[]	-6	hSpCas9	negative selection	2878622
233251883	233251906	2	+	27260157	SF268	viability	AGCAACTGAGGCGCCGGGACCGG	ATG16L1	ENSG00000085978	1.38524479993505	[]	[]	9	hSpCas9	negative selection	2882369
233264922	233264945	2	-	27260157	SF268	viability	GGTCTAGGCACTCCGTCTCCAGG	ATG16L1	ENSG00000085978	-0.508479975763596	[]	[]	-4	hSpCas9	negative selection	2885121
233277603	233277626	2	+	27260157	SF268	viability	CAGTCCAGGTTCCCGGTTACTGG	ATG16L1	ENSG00000085978	0.0813421420769756	[]	[]	0	hSpCas9	negative selection	2885415
233289898	233289921	2	-	27260157	SF268	viability	CAATCCGCGCATTGTCCAGCAGG	ATG16L1	ENSG00000085978	0.201995974390852	[]	[]	3	hSpCas9	negative selection	2887630
233256136	233256159	2	+	27260157	SF268	viability	AGTGTTGGCCCAGAAACTACAGG	ATG16L1	ENSG00000085978	0.156335317288335	[]	[]	0	hSpCas9	negative selection	2891432
233289905	233289928	2	+	27260157	SF268	viability	GACAATGCGCGGATTGTCTCAGG	ATG16L1	ENSG00000085978	-0.403325021459174	[]	[]	-3	hSpCas9	negative selection	2892055
233270051	233270074	2	-	27260157	SF268	viability	ACTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.716182691126678	[]	[]	8	hSpCas9	negative selection	2909031
233277626	233277649	2	+	27260157	SF268	viability	CCACTGGAGGCATGGACCGCAGG	ATG16L1	ENSG00000085978	0.583685710178067	[]	[]	8	hSpCas9	negative selection	2911872
233263129	233263152	2	+	27260157	SF268	viability	GTCCCGGACATGATGGCACATGG	ATG16L1	ENSG00000085978	1.16335112336271	[]	[]	9	hSpCas9	negative selection	2913706
233251872	233251895	2	-	27260157	SF268	viability	GCCTCAGTTGCTCCGAGATGTGG	ATG16L1	ENSG00000085978	-0.245890122761436	[]	[]	-2	hSpCas9	negative selection	2919329
233293253	233293276	2	+	27260157	SF268	viability	TAGCCCTGATGGCAGTTACGTGG	ATG16L1	ENSG00000085978	0.661530839919996	[]	[]	8	hSpCas9	negative selection	2919401
233289933	233289956	2	+	27260157	SF268	viability	ACGACCGGACTCTCAAACTCTGG	ATG16L1	ENSG00000085978	1.61024012230852	[]	[]	9	hSpCas9	negative selection	2920356
233273722	233273745	2	+	27260157	SF268	viability	AAGCGACTCTCGCAGCCTGCTGG	ATG16L1	ENSG00000085978	0.501571239801409	[]	[]	7	hSpCas9	negative selection	2922186
233274703	233274726	2	-	27260157	SF268	viability	GAGTATCCACATTGTCCTGGGGG	ATG16L1	ENSG00000085978	-0.0403378404192223	[]	[]	0	hSpCas9	negative selection	2922214
233264904	233264927	2	+	27260157	SF268	viability	TTTGCAGACTATCTCTGACCTGG	ATG16L1	ENSG00000085978	-0.0549884281071332	[]	[]	0	hSpCas9	negative selection	2925396
233277589	233277612	2	+	27260157	SF268	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.175161973952495	[]	[]	-1	hSpCas9	negative selection	2926450
233277642	233277665	2	-	27260157	SF268	viability	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	-0.00444917463554744	[]	[]	0	hSpCas9	negative selection	2947069
233292395	233292418	2	+	27260157	SF268	viability	GGTTCAAGTGCGGCTCTGACTGG	ATG16L1	ENSG00000085978	0.62800166125941	[]	[]	8	hSpCas9	negative selection	2949359
233292141	233292164	2	+	27260157	SF268	viability	GTTCGAGAGATGGAGCTGTTGGG	ATG16L1	ENSG00000085978	1.47389603277229	[]	[]	9	hSpCas9	negative selection	2951266
233282690	233282713	2	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AATCATTTGAAGCTGCTAAGAGG	ATG16L1	ENSG00000085978	-0.17792131268468575	[2,3]	[3,0]	-3	hSpCas9	positive selection	2972177
233270051	233270074	2	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ACTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.017194811823625256	[5,4]	[4,3]	0	hSpCas9	positive selection	2972178
233277642	233277665	2	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	0.23038951235489757	[3,4]	[4,3]	5	hSpCas9	positive selection	2972179
233273019	233273042	2	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-0.9862135073264868	[2,2]	[1,0]	-9	hSpCas9	positive selection	2972180
233282690	233282713	2	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AATCATTTGAAGCTGCTAAGAGG	ATG16L1	ENSG00000085978	-0.03906181718860441	[2,2]	[3,0]	0	hSpCas9	positive selection	3040035
233270051	233270074	2	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ACTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.29266947008051036	[5,5]	[5,3]	5	hSpCas9	positive selection	3040036
233277642	233277665	2	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	0.12313430350425116	[3,3]	[3,2]	2	hSpCas9	positive selection	3040037
233273019	233273042	2	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-0.037191101113680486	[2,2]	[2,1]	0	hSpCas9	positive selection	3040038
233277589	233277612		+	24336571	A375	resistance to PLX after 7 days	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.09217090983941395	[18,15]	[19,17]	3	hSpCas9	positive selection	3135201
233263209	233263232		+	24336571	A375	resistance to PLX after 7 days	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	0.1469640361026905	[2,6]	[3,6]	5	hSpCas9	positive selection	3135212
233263122	233263145		+	24336571	A375	resistance to PLX after 7 days	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	0.02807164200850895	[9,11]	[11,10]	1	hSpCas9	positive selection	3135223
233277642	233277665		-	24336571	A375	resistance to PLX after 7 days	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	0.13155778506166627	[11,13]	[13,13]	4	hSpCas9	positive selection	3135234
233273034	233273057		-	24336571	A375	resistance to PLX after 7 days	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.016049165541685895	[57,68]	[61,65]	0	hSpCas9	positive selection	3135245
233277589	233277612		+	24336571	A375	resistance to PLX after 14 days	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.3831844613998741	[23,18]	[5,8]	-4	hSpCas9	positive selection	3192994
233263209	233263232		+	24336571	A375	resistance to PLX after 14 days	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.03839416460162626	[4,9]	[2,2]	0	hSpCas9	positive selection	3193005
233263122	233263145		+	24336571	A375	resistance to PLX after 14 days	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	0.09398869857098036	[9,9]	[4,3]	1	hSpCas9	positive selection	3193016
233277642	233277665		-	24336571	A375	resistance to PLX after 14 days	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	-0.20156744816519329	[10,10]	[3,3]	-2	hSpCas9	positive selection	3193027
233273034	233273057		-	24336571	A375	resistance to PLX after 14 days	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.4687707193502568	[50,54]	[28,38]	4	hSpCas9	positive selection	3193038
233277589	233277612		+	24336571	A375	viability after 7 days	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.4438251609373006	[13]	[18,15]	6	hSpCas9	negative selection	3250787
233263209	233263232		+	24336571	A375	viability after 7 days	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.38130452518168534	[6]	[2,6]	-5	hSpCas9	negative selection	3250798
233263122	233263145		+	24336571	A375	viability after 7 days	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.7910866303775448	[20]	[9,11]	-8	hSpCas9	negative selection	3250809
233277642	233277665		-	24336571	A375	viability after 7 days	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	-0.01733356719242024	[13]	[11,13]	0	hSpCas9	negative selection	3250820
233273034	233273057		-	24336571	A375	viability after 7 days	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.25719676106792555	[55]	[57,68]	4	hSpCas9	negative selection	3250831
233277589	233277612		+	24336571	A375	viability after 14 days	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.7337755419182287	[13]	[23,18]	8	hSpCas9	negative selection	3308580
233263209	233263232		+	24336571	A375	viability after 14 days	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	0.12184087585287207	[6]	[4,9]	1	hSpCas9	negative selection	3308591
233263122	233263145		+	24336571	A375	viability after 14 days	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.9641982447168111	[20]	[9,9]	-8	hSpCas9	negative selection	3308602
233277642	233277665		-	24336571	A375	viability after 14 days	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	-0.2261178138568467	[13]	[10,10]	-3	hSpCas9	negative selection	3308613
233273034	233273057		-	24336571	A375	viability after 14 days	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.011852011064752865	[55]	[50,54]	0	hSpCas9	negative selection	3308624
233277638	233277661	2	+	27383988	293T	resistance to West Nile virus (flavivirus)	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	1.136961259116267	[79,58]	[0,0]	5	hSpCas9	positive selection	3337930
233263122	233263145	2	+	27383988	293T	resistance to West Nile virus (flavivirus)	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	3.561245091909639	[6,18]	[0,0]	9	hSpCas9	positive selection	3337931
233277589	233277612	2	+	27383988	293T	resistance to West Nile virus (flavivirus)	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-1.0827565968355979	[331,315]	[0,0]	-7	hSpCas9	positive selection	3337932
233263209	233263232	2	+	27383988	293T	resistance to West Nile virus (flavivirus)	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	2.0478728458168853	[36,36]	[0,0]	7	hSpCas9	positive selection	3357183
233272960	233272983	2	+	27383988	293T	resistance to West Nile virus (flavivirus)	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	-0.6851882938934047	[245,245]	[0,0]	-5	hSpCas9	positive selection	3357184
233273034	233273057	2	-	27383988	293T	resistance to West Nile virus (flavivirus)	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	-0.8248228299080366	[270,270]	[0,0]	-5	hSpCas9	positive selection	3357185
233282690	233282713	2	-	26780180	HT29	viability (Avana library 4 designs)	AATCATTTGAAGCTGCTAAGAGG	ATG16L1	ENSG00000085978	0.970304938351737	[]	[]	4	hSpCas9	negative selection	3408316
233270051	233270074	2	-	26780180	HT29	viability (Avana library 4 designs)	ACTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.766480400872057	[]	[]	3	hSpCas9	negative selection	3408317
233277642	233277665	2	-	26780180	HT29	viability (Avana library 4 designs)	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	0.645003169074113	[]	[]	2	hSpCas9	negative selection	3408318
233273019	233273042	2	-	26780180	HT29	viability (Avana library 4 designs)	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	1.5702708924313	[]	[]	6	hSpCas9	negative selection	3408319
233270051	233270074	2	-	26780180	A375	viability (Avana lentiCRISPRv2)	ACTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	4.89303269444574	[]	[]	8	hSpCas9	negative selection	3481795
233273019	233273042	2	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	3.7592963740072	[]	[]	6	hSpCas9	negative selection	3481796
233277642	233277665	2	-	26780180	A375	viability (Avana lentiCRISPRv2)	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	1.05139552976901	[]	[]	1	hSpCas9	negative selection	3481797
233282690	233282713	2	-	26780180	A375	viability (Avana lentiCRISPRv2)	AATCATTTGAAGCTGCTAAGAGG	ATG16L1	ENSG00000085978	-8.50322185143206	[]	[]	-7	hSpCas9	negative selection	3481798
233251816	233251839	2	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCAGCAAGTGACATGTCGTCGGG	ATG16L1	ENSG00000085978	3.18104513949502	[]	[]	5	hSpCas9	negative selection	3481799
233251847	233251870	2	-	26780180	A375	viability (Avana lentiCRISPRv2)	CTTCCAGCGGGGGAAGTCAGCGG	ATG16L1	ENSG00000085978	6.34533278906674	[]	[]	9	hSpCas9	negative selection	3481800
233270051	233270074	2	-	26780180	A375	viability (Avana lentiGuide)	ACTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	-4.70744828078519	[]	[]	-7	hSpCas9	negative selection	3590454
233273019	233273042	2	-	26780180	A375	viability (Avana lentiGuide)	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.887683528652718	[]	[]	1	hSpCas9	negative selection	3590455
233277642	233277665	2	-	26780180	A375	viability (Avana lentiGuide)	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	0.565766291908453	[]	[]	0	hSpCas9	negative selection	3590456
233282690	233282713	2	-	26780180	A375	viability (Avana lentiGuide)	AATCATTTGAAGCTGCTAAGAGG	ATG16L1	ENSG00000085978	-13.0559789809087	[]	[]	-9	hSpCas9	negative selection	3590457
233251816	233251839	2	+	26780180	A375	viability (Avana lentiGuide)	GCAGCAAGTGACATGTCGTCGGG	ATG16L1	ENSG00000085978	-2.90049943825994	[]	[]	-5	hSpCas9	negative selection	3590458
233251847	233251870	2	-	26780180	A375	viability (Avana lentiGuide)	CTTCCAGCGGGGGAAGTCAGCGG	ATG16L1	ENSG00000085978	-1.67760996851296	[]	[]	-3	hSpCas9	negative selection	3590459
233270051	233270074	2	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ACTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.18374062175458566	[6]	[7,6]	5	hSpCas9	positive selection	3699113
233273019	233273042	2	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.12618502431746398	[4]	[5,4]	3	hSpCas9	positive selection	3699114
233277642	233277665	2	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	0.14178340600923559	[5]	[6,5]	4	hSpCas9	positive selection	3699115
233282690	233282713	2	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AATCATTTGAAGCTGCTAAGAGG	ATG16L1	ENSG00000085978	-0.15754846304103043	[5]	[4,4]	-3	hSpCas9	positive selection	3699116
233251816	233251839	2	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAGCAAGTGACATGTCGTCGGG	ATG16L1	ENSG00000085978	0.3534598107835927	[4]	[6,5]	9	hSpCas9	positive selection	3699117
233251847	233251870	2	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTTCCAGCGGGGGAAGTCAGCGG	ATG16L1	ENSG00000085978	0.5139419323515089	[4]	[6,6]	9	hSpCas9	positive selection	3699118
233270051	233270074	2	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ACTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.29313383066086546	[6]	[7,6]	7	hSpCas9	positive selection	3807720
233273019	233273042	2	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-0.4694577315019941	[4]	[2,2]	-6	hSpCas9	positive selection	3807721
233277642	233277665	2	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	-0.23637646113621846	[6]	[3,5]	-3	hSpCas9	positive selection	3807722
233282690	233282713	2	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AATCATTTGAAGCTGCTAAGAGG	ATG16L1	ENSG00000085978	0.582285637056708	[4]	[5,6]	9	hSpCas9	positive selection	3807723
233251816	233251839	2	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAGCAAGTGACATGTCGTCGGG	ATG16L1	ENSG00000085978	0.24892864566436645	[5]	[6,4]	6	hSpCas9	positive selection	3807724
233251847	233251870	2	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTTCCAGCGGGGGAAGTCAGCGG	ATG16L1	ENSG00000085978	-0.04140864072584669	[5]	[4,3]	0	hSpCas9	positive selection	3807725
233277589	233277612	2	+	26780180	A375	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	1.31822221148858	[]	[]	7	hSpCas9	negative selection	3915969
233263209	233263232	2	+	26780180	A375	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	0.829975747300155	[]	[]	3	hSpCas9	negative selection	3915970
233263122	233263145	2	+	26780180	A375	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	0.272501757896949	[]	[]	0	hSpCas9	negative selection	3915971
233277638	233277661	2	+	26780180	A375	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.74604910514266	[]	[]	2	hSpCas9	negative selection	3915972
233273034	233273057	2	-	26780180	A375	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	1.20429496604465	[]	[]	6	hSpCas9	negative selection	3915973
233272960	233272983	2	+	26780180	A375	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	1.012647219475	[]	[]	5	hSpCas9	negative selection	3915974
233277589	233277612	2	+	26780180	HT29	viability (GeCKOv2 library)	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	1.4818284041691	[]	[]	7	hSpCas9	negative selection	4023935
233263209	233263232	2	+	26780180	HT29	viability (GeCKOv2 library)	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	0.706468750984426	[]	[]	2	hSpCas9	negative selection	4023936
233263122	233263145	2	+	26780180	HT29	viability (GeCKOv2 library)	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	0.476723285893687	[]	[]	1	hSpCas9	negative selection	4023937
233277638	233277661	2	+	26780180	HT29	viability (GeCKOv2 library)	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	1.091326921758	[]	[]	5	hSpCas9	negative selection	4023938
233273034	233273057	2	-	26780180	HT29	viability (GeCKOv2 library)	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.97547824399982	[]	[]	4	hSpCas9	negative selection	4023939
233272960	233272983	2	+	26780180	HT29	viability (GeCKOv2 library)	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.974220055520044	[]	[]	4	hSpCas9	negative selection	4023940
233277589	233277612	2	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.11254000707415457	[3]	[1,2]	-3	hSpCas9	positive selection	4160122
233263209	233263232	2	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	0.00015174301978249094	[2]	[1,1]	0	hSpCas9	positive selection	4160133
233263122	233263145	2	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.05892503027381587	[3]	[2,2]	-1	hSpCas9	positive selection	4160144
233277642	233277665	2	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	-0.11745608711329698	[3]	[2,1]	-3	hSpCas9	positive selection	4160155
233273034	233273057	2	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.12726317628654726	[6]	[4,5]	3	hSpCas9	positive selection	4160166
233277589	233277612	2	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.21460625869266053	[4]	[1,2,0,0]	-3	hSpCas9	positive selection	4224144
233263209	233263232	2	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	0.9477594836235683	[3]	[3,0,4,3]	6	hSpCas9	positive selection	4224155
233263122	233263145	2	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	1.0581181224920029	[4]	[3,3,4,4]	7	hSpCas9	positive selection	4224166
233277642	233277665	2	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTTCCCAAAGCTTAACCCTGCGG	ATG16L1	ENSG00000085978	0.21243027131654013	[3]	[4,1,1,0]	1	hSpCas9	positive selection	4224177
233273034	233273057	2	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.3794194026347695	[5]	[5,3,4,0]	3	hSpCas9	positive selection	4224188
233277638	233277661	2	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.008002279863650541	[1]	[2,0]	0	hSpCas9	positive selection	4257174
233263122	233263145	2	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	0.03685483621704089	[0]	[0,0]	0	hSpCas9	positive selection	4257175
233277589	233277612	2	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.06766913374751377	[4]	[4,2]	1	hSpCas9	positive selection	4257176
233263209	233263232	2	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.08281419358679165	[1]	[2,0]	-2	hSpCas9	positive selection	4321458
233272960	233272983	2	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	-0.11036078682976078	[3]	[3,0]	-2	hSpCas9	positive selection	4321459
233273034	233273057	2	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	-0.058666237746445464	[3]	[3,1]	-1	hSpCas9	positive selection	4321460
233270051	233270073	2	-	27760321	OCIAML3	viability	CTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.041751848814338466	[609,555]	[505,420]	0	hSpCas9	negative selection	4380259
233273019	233273041	2	-	27760321	OCIAML3	viability	CTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-0.0015337111619485727	[516,414]	[272,477]	0	hSpCas9	negative selection	4380260
233274728	233274750	2	-	27760321	OCIAML3	viability	TCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.03488984122513361	[313,279]	[277,184]	0	hSpCas9	negative selection	4380261
233277628	233277650	2	+	27760321	OCIAML3	viability	ACTGGAGGCATGGACCGCAGGG	ATG16L1	ENSG00000085978	0.13730224500373855	[866,656]	[578,742]	1	hSpCas9	negative selection	4380262
233281126	233281148	2	-	27760321	OCIAML3	viability	CCTGCATTACTGCCAGATAGGG	ATG16L1	ENSG00000085978	0.2957690023353058	[370,320]	[352,302]	3	hSpCas9	negative selection	4380263
233270051	233270073	2	-	27760321	OCIAML2	viability	CTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.1654338646610185	[609,555]	[453,626]	2	hSpCas9	negative selection	4463722
233273019	233273041	2	-	27760321	OCIAML2	viability	CTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.4230675190314612	[516,414]	[420,609]	6	hSpCas9	negative selection	4463723
233274728	233274750	2	-	27760321	OCIAML2	viability	TCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.9076116629889319	[313,279]	[396,519]	9	hSpCas9	negative selection	4463724
233277628	233277650	2	+	27760321	OCIAML2	viability	ACTGGAGGCATGGACCGCAGGG	ATG16L1	ENSG00000085978	0.3599261563411126	[866,656]	[612,1010]	5	hSpCas9	negative selection	4463725
233281126	233281148	2	-	27760321	OCIAML2	viability	CCTGCATTACTGCCAGATAGGG	ATG16L1	ENSG00000085978	0.4382111184579769	[370,320]	[259,533]	6	hSpCas9	negative selection	4463726
233270051	233270073	2	-	27760321	MV411	viability	CTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	-0.3438394368152752	[609,555]	[280,335]	-2	hSpCas9	negative selection	4547185
233273019	233273041	2	-	27760321	MV411	viability	CTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-0.5978482409692047	[516,414]	[235,150]	-4	hSpCas9	negative selection	4547186
233274728	233274750	2	-	27760321	MV411	viability	TCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.7546298645115431	[313,279]	[338,316]	5	hSpCas9	negative selection	4547187
233277628	233277650	2	+	27760321	MV411	viability	ACTGGAGGCATGGACCGCAGGG	ATG16L1	ENSG00000085978	-0.17536448425371376	[866,656]	[340,592]	-1	hSpCas9	negative selection	4547188
233281126	233281148	2	-	27760321	MV411	viability	CCTGCATTACTGCCAGATAGGG	ATG16L1	ENSG00000085978	-0.4171398984455191	[370,320]	[100,274]	-3	hSpCas9	negative selection	4547189
233270051	233270073	2	-	27760321	HL60	viability	CTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.10192198312464529	[609,555]	[521,498]	1	hSpCas9	negative selection	4630648
233273019	233273041	2	-	27760321	HL60	viability	CTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.4770926021778008	[516,414]	[504,549]	6	hSpCas9	negative selection	4630649
233274728	233274750	2	-	27760321	HL60	viability	TCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.1837190093204858	[313,279]	[313,233]	2	hSpCas9	negative selection	4630650
233277628	233277650	2	+	27760321	HL60	viability	ACTGGAGGCATGGACCGCAGGG	ATG16L1	ENSG00000085978	-0.3607072997191767	[866,656]	[459,502]	-4	hSpCas9	negative selection	4630651
233281126	233281148	2	-	27760321	HL60	viability	CCTGCATTACTGCCAGATAGGG	ATG16L1	ENSG00000085978	0.2585222378440851	[370,320]	[277,399]	3	hSpCas9	negative selection	4630652
233270051	233270073	2	-	27760321	HT1080	viability	CTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	-0.2778395547443282	[555,433]	[207,112]	-1	hSpCas9	negative selection	4714111
233273019	233273041	2	-	27760321	HT1080	viability	CTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.6599733469025194	[414,323]	[265,195]	3	hSpCas9	negative selection	4714112
233274728	233274750	2	-	27760321	HT1080	viability	TCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.8068345556209635	[279,218]	[97,256]	4	hSpCas9	negative selection	4714113
233277628	233277650	2	+	27760321	HT1080	viability	ACTGGAGGCATGGACCGCAGGG	ATG16L1	ENSG00000085978	0.9750052895330186	[656,512]	[259,674]	5	hSpCas9	negative selection	4714114
233281126	233281148	2	-	27760321	HT1080	viability	CCTGCATTACTGCCAGATAGGG	ATG16L1	ENSG00000085978	-2.678868668668126	[320,250]	[23,10]	-7	hSpCas9	negative selection	4714115
233270051	233270073	2	-	27760321	HT29	viability after 7 days	CTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	-0.131714786697199	[555,433]	[758,450,557]	-2	hSpCas9	negative selection	4797574
233273019	233273041	2	-	27760321	HT29	viability after 7 days	CTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.35679747120135247	[414,323]	[512,445,843]	5	hSpCas9	negative selection	4797575
233274728	233274750	2	-	27760321	HT29	viability after 7 days	TCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	-0.2527608536484732	[279,218]	[214,293,289]	-4	hSpCas9	negative selection	4797576
233277628	233277650	2	+	27760321	HT29	viability after 7 days	ACTGGAGGCATGGACCGCAGGG	ATG16L1	ENSG00000085978	0.6667212660302941	[656,512]	[1343,1071,1185]	8	hSpCas9	negative selection	4797577
233281126	233281148	2	-	27760321	HT29	viability after 7 days	CCTGCATTACTGCCAGATAGGG	ATG16L1	ENSG00000085978	0.49580266356807473	[320,250]	[786,406,402]	7	hSpCas9	negative selection	4797578
233270051	233270073	2	-	27760321	HT29	viability after 25 days	CTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	-0.1954680424412582	[555,433]	[563,555,340]	-2	hSpCas9	negative selection	4881037
233273019	233273041	2	-	27760321	HT29	viability after 25 days	CTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.3692644901091884	[414,323]	[388,679,579]	4	hSpCas9	negative selection	4881038
233274728	233274750	2	-	27760321	HT29	viability after 25 days	TCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.14369110462646317	[279,218]	[245,473,218]	1	hSpCas9	negative selection	4881039
233277628	233277650	2	+	27760321	HT29	viability after 25 days	ACTGGAGGCATGGACCGCAGGG	ATG16L1	ENSG00000085978	0.40872817869318845	[656,512]	[883,988,776]	4	hSpCas9	negative selection	4881040
233281126	233281148	2	-	27760321	HT29	viability after 25 days	CCTGCATTACTGCCAGATAGGG	ATG16L1	ENSG00000085978	-0.18091513632951922	[320,250]	[260,233,380]	-2	hSpCas9	negative selection	4881041
233270051	233270073	2	-	27760321	HT29	viability after 22 days	CTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.017233760386448416	[555,433]	[704,653,372]	0	hSpCas9	negative selection	4964500
233273019	233273041	2	-	27760321	HT29	viability after 22 days	CTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.6567311185918627	[414,323]	[675,796,545]	7	hSpCas9	negative selection	4964501
233274728	233274750	2	-	27760321	HT29	viability after 22 days	TCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	-0.1958937407515623	[279,218]	[225,301,227]	-2	hSpCas9	negative selection	4964502
233277628	233277650	2	+	27760321	HT29	viability after 22 days	ACTGGAGGCATGGACCGCAGGG	ATG16L1	ENSG00000085978	0.5833167930640557	[656,512]	[1086,1029,919]	6	hSpCas9	negative selection	4964503
233281126	233281148	2	-	27760321	HT29	viability after 22 days	CCTGCATTACTGCCAGATAGGG	ATG16L1	ENSG00000085978	-0.7096506098660851	[320,250]	[119,264,223]	-5	hSpCas9	negative selection	4964504
233270051	233270073	2	-	27760321	HT29	viability after 19 days	CTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	-0.2506020241474912	[555,433]	[382,383,643]	-2	hSpCas9	negative selection	5047963
233273019	233273041	2	-	27760321	HT29	viability after 19 days	CTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.46375797060230106	[414,323]	[526,465,742]	4	hSpCas9	negative selection	5047964
233274728	233274750	2	-	27760321	HT29	viability after 19 days	TCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	-0.1140753700351611	[279,218]	[424,151,231]	-1	hSpCas9	negative selection	5047965
233277628	233277650	2	+	27760321	HT29	viability after 19 days	ACTGGAGGCATGGACCGCAGGG	ATG16L1	ENSG00000085978	0.476750239706339	[656,512]	[1131,786,895]	5	hSpCas9	negative selection	5047966
233281126	233281148	2	-	27760321	HT29	viability after 19 days	CCTGCATTACTGCCAGATAGGG	ATG16L1	ENSG00000085978	-0.23306784352615367	[320,250]	[199,358,267]	-2	hSpCas9	negative selection	5047967
233270051	233270073	2	-	27760321	HT29	viability after 16 days	CTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.2385919161041839	[555,433]	[1038,329,635]	2	hSpCas9	negative selection	5131426
233273019	233273041	2	-	27760321	HT29	viability after 16 days	CTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.11242219616751589	[414,323]	[410,571,350]	1	hSpCas9	negative selection	5131427
233274728	233274750	2	-	27760321	HT29	viability after 16 days	TCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.06404543166816773	[279,218]	[244,294,330]	0	hSpCas9	negative selection	5131428
233277628	233277650	2	+	27760321	HT29	viability after 16 days	ACTGGAGGCATGGACCGCAGGG	ATG16L1	ENSG00000085978	0.430938296244326	[656,512]	[1119,935,611]	5	hSpCas9	negative selection	5131429
233281126	233281148	2	-	27760321	HT29	viability after 16 days	CCTGCATTACTGCCAGATAGGG	ATG16L1	ENSG00000085978	-0.2469383954150252	[320,250]	[299,339,169]	-3	hSpCas9	negative selection	5131430
233270051	233270073	2	-	27760321	HT29	viability after 13 days	CTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.08230065548194959	[555,433]	[770,658,405]	1	hSpCas9	negative selection	5214889
233273019	233273041	2	-	27760321	HT29	viability after 13 days	CTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.4573512955400542	[414,323]	[633,704,435]	6	hSpCas9	negative selection	5214890
233274728	233274750	2	-	27760321	HT29	viability after 13 days	TCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.1700153877351429	[279,218]	[426,244,305]	2	hSpCas9	negative selection	5214891
233277628	233277650	2	+	27760321	HT29	viability after 13 days	ACTGGAGGCATGGACCGCAGGG	ATG16L1	ENSG00000085978	0.6002044745902961	[656,512]	[1195,1049,850]	7	hSpCas9	negative selection	5214892
233281126	233281148	2	-	27760321	HT29	viability after 13 days	CCTGCATTACTGCCAGATAGGG	ATG16L1	ENSG00000085978	0.12742475361910754	[320,250]	[331,436,320]	1	hSpCas9	negative selection	5214893
233270051	233270073	2	-	27760321	HT29	viability after 10 days	CTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.053546389071416456	[555,433]	[572,889,471]	0	hSpCas9	negative selection	5298352
233273019	233273041	2	-	27760321	HT29	viability after 10 days	CTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.45450039251992397	[414,323]	[422,1036,451]	6	hSpCas9	negative selection	5298353
233274728	233274750	2	-	27760321	HT29	viability after 10 days	TCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	-0.10790328285646444	[279,218]	[408,149,303]	-1	hSpCas9	negative selection	5298354
233277628	233277650	2	+	27760321	HT29	viability after 10 days	ACTGGAGGCATGGACCGCAGGG	ATG16L1	ENSG00000085978	0.8191838361838331	[656,512]	[1288,1366,1213]	9	hSpCas9	negative selection	5298355
233281126	233281148	2	-	27760321	HT29	viability after 10 days	CCTGCATTACTGCCAGATAGGG	ATG16L1	ENSG00000085978	0.08711068821264992	[320,250]	[344,574,226]	1	hSpCas9	negative selection	5298356
233270051	233270073	2	-	27760321	MOLM13	viability	CTTACTGTTCGACTGGTAGAGG	ATG16L1	ENSG00000085978	0.04451097435991641	[609,555]	[149,499]	0	hSpCas9	negative selection	5381815
233273019	233273041	2	-	27760321	MOLM13	viability	CTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.7813929004901752	[516,414]	[787,160]	5	hSpCas9	negative selection	5381816
233274728	233274750	2	-	27760321	MOLM13	viability	TCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.9176700500838137	[313,279]	[334,299]	6	hSpCas9	negative selection	5381817
233277628	233277650	2	+	27760321	MOLM13	viability	ACTGGAGGCATGGACCGCAGGG	ATG16L1	ENSG00000085978	-1.8887803835779549	[866,656]	[112,116]	-8	hSpCas9	negative selection	5381818
233281126	233281148	2	-	27760321	MOLM13	viability	CCTGCATTACTGCCAGATAGGG	ATG16L1	ENSG00000085978	-0.6442991957298969	[370,320]	[237,27]	-4	hSpCas9	negative selection	5381819
233251674	233251697	2	+	27661255	K562	viability	GACCGTCCCGGATGGCCTCGGGG	ATG16L1	ENSG00000085978	0.03344997735655951	[722,894]	[741,587]	1	dCas9-KRAB	negative selection	5463998
233251711	233251734	2	+	27661255	K562	viability	GAGGTGAGCTCCGGGATTGCCGG	ATG16L1	ENSG00000085978	0.08523820242516147	[604,704]	[613,501]	3	dCas9-KRAB	negative selection	5463999
233251871	233251894	2	+	27661255	K562	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	-0.12675919958668722	[677,666]	[577,418]	-4	dCas9-KRAB	negative selection	5464000
233277638	233277661	2	+	27260156	BXPC3	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.15378023777400274	[157]	[117,114,172,198]	-4	hSpCas9	negative selection	5529634
233263122	233263145	2	+	27260156	BXPC3	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.23529031528012379	[28]	[2,20,57,23]	-5	hSpCas9	negative selection	5529635
233277589	233277612	2	+	27260156	BXPC3	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.017068305877028234	[1081]	[980,1047,1225,1368]	0	hSpCas9	negative selection	5529636
233263209	233263232	2	+	27260156	BXPC3	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.25567959453557854	[196]	[168,179,172,165]	-5	hSpCas9	negative selection	5593918
233272960	233272983	2	+	27260156	BXPC3	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.277033939850477	[529]	[746,691,628,592]	6	hSpCas9	negative selection	5593919
233273034	233273057	2	-	27260156	BXPC3	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.014146653272008258	[590]	[486,567,684,791]	0	hSpCas9	negative selection	5593920
233277638	233277661	2	+	27260156	A673	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.026459356446564053	[157]	[232,228,191,117]	0	hSpCas9	negative selection	5650885
233263122	233263145	2	+	27260156	A673	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.4915927216842091	[28]	[12,39,23,19]	-8	hSpCas9	negative selection	5650886
233277589	233277612	2	+	27260156	A673	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.014601634747777092	[1081]	[1563,1356,1164,1182]	0	hSpCas9	negative selection	5650887
233263209	233263232	2	+	27260156	A673	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.13155451190805545	[196]	[227,214,158,265]	-3	hSpCas9	negative selection	5715169
233272960	233272983	2	+	27260156	A673	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.21293936789327966	[529]	[912,632,547,887]	5	hSpCas9	negative selection	5715170
233273034	233273057	2	-	27260156	A673	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.12443704799272581	[590]	[807,632,976,674]	3	hSpCas9	negative selection	5715171
233277638	233277661	2	+	27260156	A375	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.6492899943903984	[157]	[384,256,213,295]	8	hSpCas9	negative selection	5772136
233263122	233263145	2	+	27260156	A375	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.629538304176446	[28]	[65,4,15,0]	-7	hSpCas9	negative selection	5772137
233277589	233277612	2	+	27260156	A375	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.20357633398488595	[1081]	[1371,1940,1202,1375]	3	hSpCas9	negative selection	5772138
233263209	233263232	2	+	27260156	A375	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	0.39729424122985146	[196]	[315,359,239,302]	6	hSpCas9	negative selection	5836420
233272960	233272983	2	+	27260156	A375	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.9282765454305817	[529]	[976,1319,1409,1035]	9	hSpCas9	negative selection	5836421
233273034	233273057	2	-	27260156	A375	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.3539696417382798	[590]	[987,805,814,903]	5	hSpCas9	negative selection	5836422
233277638	233277661	2	+	27260156	COLO741	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.07102492251395343	[157]	[200,171,202]	-1	hSpCas9	negative selection	5893387
233263122	233263145	2	+	27260156	COLO741	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-1.720070609101671	[28]	[19,10,3]	-9	hSpCas9	negative selection	5893388
233277589	233277612	2	+	27260156	COLO741	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.08285175651247423	[1081]	[1533,1176,1226]	-2	hSpCas9	negative selection	5893389
233263209	233263232	2	+	27260156	COLO741	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	0.008018768967559486	[196]	[292,228,240]	0	hSpCas9	negative selection	5957671
233272960	233272983	2	+	27260156	COLO741	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.007078272738086616	[529]	[753,665,629]	0	hSpCas9	negative selection	5957672
233273034	233273057	2	-	27260156	COLO741	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.11871689099251292	[590]	[857,852,754]	2	hSpCas9	negative selection	5957673
233277638	233277661	2	+	27260156	CAL120	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.036840196126258995	[157]	[233,196,150]	0	hSpCas9	negative selection	6014638
233263122	233263145	2	+	27260156	CAL120	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-1.5170292368568514	[28]	[1,8,24]	-9	hSpCas9	negative selection	6014639
233277589	233277612	2	+	27260156	CAL120	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.013816002290037321	[1081]	[1468,1407,1146]	0	hSpCas9	negative selection	6014640
233263209	233263232	2	+	27260156	CAL120	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.04042813521820121	[196]	[310,179,234]	0	hSpCas9	negative selection	6078922
233272960	233272983	2	+	27260156	CAL120	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.07981588375245974	[529]	[860,752,504]	1	hSpCas9	negative selection	6078923
233273034	233273057	2	-	27260156	CAL120	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	-0.01598647069940029	[590]	[914,627,667]	0	hSpCas9	negative selection	6078924
233277638	233277661	2	+	27260156	CADOES1	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.10203182825186974	[157]	[182,181,87,92]	-2	hSpCas9	negative selection	6135889
233263122	233263145	2	+	27260156	CADOES1	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-1.02024326089857	[28]	[3,23,17,6]	-9	hSpCas9	negative selection	6135890
233277589	233277612	2	+	27260156	CADOES1	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.17067832830001595	[1081]	[1098,1312,1019,1097]	3	hSpCas9	negative selection	6135891
233263209	233263232	2	+	27260156	CADOES1	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	0.2011172462886872	[196]	[175,147,191,330]	3	hSpCas9	negative selection	6200173
233272960	233272983	2	+	27260156	CADOES1	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.3293484695696393	[529]	[682,620,533,639]	5	hSpCas9	negative selection	6200174
233273034	233273057	2	-	27260156	CADOES1	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	-0.05494342472653252	[590]	[502,552,648,406]	-1	hSpCas9	negative selection	6200175
233277638	233277661	2	+	27260156	EWS502	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.392967454246852	[157]	[128,164,260,345]	7	hSpCas9	negative selection	6257140
233263122	233263145	2	+	27260156	EWS502	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-1.8035252985563561	[28]	[6,8,16,1]	-9	hSpCas9	negative selection	6257141
233277589	233277612	2	+	27260156	EWS502	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.07645494991354562	[1081]	[1192,845,1234,1599]	1	hSpCas9	negative selection	6257142
233263209	233263232	2	+	27260156	EWS502	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.09397601265597455	[196]	[186,134,215,250]	-2	hSpCas9	negative selection	6321424
233272960	233272983	2	+	27260156	EWS502	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.142625077851521	[529]	[747,565,635,504]	2	hSpCas9	negative selection	6321425
233273034	233273057	2	-	27260156	EWS502	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	-0.2435808320086518	[590]	[340,695,471,625]	-4	hSpCas9	negative selection	6321426
233277638	233277661	2	+	27260156	EW8	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.2281274386699772	[157]	[174,97,86,87]	-4	hSpCas9	negative selection	6378391
233263122	233263145	2	+	27260156	EW8	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	0.1462979829756601	[28]	[1,35,9,55]	2	hSpCas9	negative selection	6378392
233277589	233277612	2	+	27260156	EW8	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.011881628864736538	[1081]	[1340,689,679,906]	0	hSpCas9	negative selection	6378393
233263209	233263232	2	+	27260156	EW8	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.2078408866813375	[196]	[93,107,133,211]	-4	hSpCas9	negative selection	6442675
233272960	233272983	2	+	27260156	EW8	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.088266537798319	[529]	[620,330,358,547]	1	hSpCas9	negative selection	6442676
233273034	233273057	2	-	27260156	EW8	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.30570310178038596	[590]	[618,723,569,460]	5	hSpCas9	negative selection	6442677
233277638	233277661	2	+	27260156	CORL105	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.24197147836735233	[157]	[231,239,236,168]	4	hSpCas9	negative selection	6499642
233263122	233263145	2	+	27260156	CORL105	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.679284392949044	[28]	[4,6,24,47]	-8	hSpCas9	negative selection	6499643
233277589	233277612	2	+	27260156	CORL105	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.021098539579145204	[1081]	[1150,1493,1250,1230]	0	hSpCas9	negative selection	6499644
233263209	233263232	2	+	27260156	CORL105	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.0022165113852306018	[196]	[159,274,313,181]	0	hSpCas9	negative selection	6563926
233272960	233272983	2	+	27260156	CORL105	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.2321045296637474	[529]	[784,737,854,558]	4	hSpCas9	negative selection	6563927
233273034	233273057	2	-	27260156	CORL105	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.11334356780136717	[590]	[942,628,774,659]	2	hSpCas9	negative selection	6563928
233277638	233277661	2	+	27260156	HS294T	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.9707987914206397	[157]	[29,30,35,26]	-8	hSpCas9	negative selection	6620893
233263122	233263145	2	+	27260156	HS294T	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-1.083804750487217	[28]	[3,1,6,8]	-9	hSpCas9	negative selection	6620894
233277589	233277612	2	+	27260156	HS294T	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.24482592875072462	[1081]	[367,715,391,512]	3	hSpCas9	negative selection	6620895
233263209	233263232	2	+	27260156	HS294T	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.318721123809411	[196]	[70,34,76,60]	-4	hSpCas9	negative selection	6685177
233272960	233272983	2	+	27260156	HS294T	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.2290744921174669	[529]	[291,269,130,264]	3	hSpCas9	negative selection	6685178
233273034	233273057	2	-	27260156	HS294T	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.07606488530652195	[590]	[262,247,224,220]	1	hSpCas9	negative selection	6685179
233277638	233277661	2	+	27260156	HCC44	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.20022609108741118	[157]	[155,102,182,189]	-3	hSpCas9	negative selection	6742144
233263122	233263145	2	+	27260156	HCC44	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.3271752683073137	[28]	[0,62,28,4]	-5	hSpCas9	negative selection	6742145
233277589	233277612	2	+	27260156	HCC44	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.10960352682433405	[1081]	[1289,752,1194,1360]	-2	hSpCas9	negative selection	6742146
233263209	233263232	2	+	27260156	HCC44	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.3968780310103548	[196]	[167,204,95,187]	-6	hSpCas9	negative selection	6806428
233272960	233272983	2	+	27260156	HCC44	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.11550922954507015	[529]	[544,678,876,520]	1	hSpCas9	negative selection	6806429
233273034	233273057	2	-	27260156	HCC44	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	-0.010153664773099091	[590]	[701,615,857,521]	0	hSpCas9	negative selection	6806430
233277638	233277661	2	+	27260156	G402	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.14988964639360303	[157]	[120,288,354,86]	2	hSpCas9	negative selection	6863395
233263122	233263145	2	+	27260156	G402	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.7431941994735602	[28]	[0,31,44,4]	-7	hSpCas9	negative selection	6863396
233277589	233277612	2	+	27260156	G402	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.048300083422055495	[1081]	[581,1330,2132,973]	0	hSpCas9	negative selection	6863397
233263209	233263232	2	+	27260156	G402	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.35711690357119275	[196]	[186,307,140,123]	-4	hSpCas9	negative selection	6927679
233272960	233272983	2	+	27260156	G402	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	-0.008929074842984858	[529]	[937,639,689,356]	0	hSpCas9	negative selection	6927680
233273034	233273057	2	-	27260156	G402	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	-0.4583711571046	[590]	[922,402,555,277]	-5	hSpCas9	negative selection	6927681
233277638	233277661	2	+	27260156	L33	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.021494794274697915	[157]	[144,84,74,150]	0	hSpCas9	negative selection	6984646
233263122	233263145	2	+	27260156	L33	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	0.0035654105579405737	[28]	[34,16,5,29]	0	hSpCas9	negative selection	6984647
233277589	233277612	2	+	27260156	L33	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.18202846561413333	[1081]	[1032,340,558,1056]	-4	hSpCas9	negative selection	6984648
233263209	233263232	2	+	27260156	L33	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.16989018399085554	[196]	[138,89,98,184]	-4	hSpCas9	negative selection	7048930
233272960	233272983	2	+	27260156	L33	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	-0.04829544850941933	[529]	[469,224,375,434]	-1	hSpCas9	negative selection	7048931
233273034	233273057	2	-	27260156	L33	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.27179684217014854	[590]	[768,230,479,755]	6	hSpCas9	negative selection	7048932
233277638	233277661	2	+	27260156	K562	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.20366243519043725	[157]	[115,203,230,99]	2	hSpCas9	negative selection	7105897
233263122	233263145	2	+	27260156	K562	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-1.5428902615715723	[28]	[6,1,18,6]	-9	hSpCas9	negative selection	7105898
233277589	233277612	2	+	27260156	K562	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.3953693079583085	[1081]	[510,1083,708,625]	-5	hSpCas9	negative selection	7105899
233263209	233263232	2	+	27260156	K562	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.999794918664904	[196]	[55,85,25,168]	-8	hSpCas9	negative selection	7170181
233272960	233272983	2	+	27260156	K562	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.17808276975434179	[529]	[526,658,522,434]	2	hSpCas9	negative selection	7170182
233273034	233273057	2	-	27260156	K562	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.26396193080964914	[590]	[578,738,513,679]	3	hSpCas9	negative selection	7170183
233277638	233277661	2	+	27260156	HT29	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.09850992125547986	[157]	[170,190,319,142]	2	hSpCas9	negative selection	7227148
233263122	233263145	2	+	27260156	HT29	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.21318620496599738	[28]	[6,0,23,78]	-4	hSpCas9	negative selection	7227149
233277589	233277612	2	+	27260156	HT29	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.0033445920027690423	[1081]	[1403,1093,1410,1317]	0	hSpCas9	negative selection	7227150
233263209	233263232	2	+	27260156	HT29	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.06257299447394615	[196]	[272,278,202,174]	-1	hSpCas9	negative selection	7291432
233272960	233272983	2	+	27260156	HT29	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.19069859632159636	[529]	[742,811,678,711]	4	hSpCas9	negative selection	7291433
233273034	233273057	2	-	27260156	HT29	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.020758157827423296	[590]	[750,921,756,523]	0	hSpCas9	negative selection	7291434
233277638	233277661	2	+	27260156	MHHES1	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.02317832325957192	[157]	[324,138,214,77]	0	hSpCas9	negative selection	7348399
233263122	233263145	2	+	27260156	MHHES1	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.14483423018836739	[28]	[13,54,18,29]	-3	hSpCas9	negative selection	7348400
233277589	233277612	2	+	27260156	MHHES1	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.012281693445110209	[1081]	[1195,1857,1157,762]	0	hSpCas9	negative selection	7348401
233263209	233263232	2	+	27260156	MHHES1	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.3955914487713139	[196]	[263,228,48,149]	-6	hSpCas9	negative selection	7412683
233272960	233272983	2	+	27260156	MHHES1	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.08696996807679264	[529]	[679,542,646,644]	1	hSpCas9	negative selection	7412684
233273034	233273057	2	-	27260156	MHHES1	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.08210669643202517	[590]	[771,959,599,541]	1	hSpCas9	negative selection	7412685
233277638	233277661	2	+	27260156	MEWO	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.2843698506719421	[157]	[120,125,116]	-6	hSpCas9	negative selection	7469650
233263122	233263145	2	+	27260156	MEWO	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.9805860666250279	[28]	[27,14,0]	-9	hSpCas9	negative selection	7469651
233277589	233277612	2	+	27260156	MEWO	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.08334130984108934	[1081]	[1131,619,1149]	-2	hSpCas9	negative selection	7469652
233263209	233263232	2	+	27260156	MEWO	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	0.4347703417885196	[196]	[219,182,338]	8	hSpCas9	negative selection	7533934
233272960	233272983	2	+	27260156	MEWO	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.21663953185946178	[529]	[520,727,467]	5	hSpCas9	negative selection	7533935
233273034	233273057	2	-	27260156	MEWO	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.1822234860362213	[590]	[665,507,715]	4	hSpCas9	negative selection	7533936
233277638	233277661	2	+	27260156	LNCAPCLONEFGC	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.024716330121482555	[157]	[121,148,168,145]	0	hSpCas9	negative selection	7590901
233263122	233263145	2	+	27260156	LNCAPCLONEFGC	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.23055425584924105	[28]	[43,14,24,5]	-4	hSpCas9	negative selection	7590902
233277589	233277612	2	+	27260156	LNCAPCLONEFGC	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.004934618332574914	[1081]	[914,726,1093,1231]	0	hSpCas9	negative selection	7590903
233263209	233263232	2	+	27260156	LNCAPCLONEFGC	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.13274778343143678	[196]	[164,111,133,238]	-2	hSpCas9	negative selection	7655185
233272960	233272983	2	+	27260156	LNCAPCLONEFGC	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.08948087215858469	[529]	[522,364,622,557]	1	hSpCas9	negative selection	7655186
233273034	233273057	2	-	27260156	LNCAPCLONEFGC	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.091327768531826	[590]	[462,623,559,630]	1	hSpCas9	negative selection	7655187
233277638	233277661	2	+	27260156	PANC0327	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.4464711752458219	[157]	[80,157,70,92]	-6	hSpCas9	negative selection	7712152
233263122	233263145	2	+	27260156	PANC0327	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	1.1095120120213018	[28]	[131,20,23,55]	9	hSpCas9	negative selection	7712153
233277589	233277612	2	+	27260156	PANC0327	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.19076074250434472	[1081]	[1490,688,1235,1056]	3	hSpCas9	negative selection	7712154
233263209	233263232	2	+	27260156	PANC0327	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.7363112051728748	[196]	[85,155,88,80]	-7	hSpCas9	negative selection	7776436
233272960	233272983	2	+	27260156	PANC0327	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.019119590723468638	[529]	[494,445,619,352]	0	hSpCas9	negative selection	7776437
233273034	233273057	2	-	27260156	PANC0327	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.10789423073735416	[590]	[601,656,504,489]	1	hSpCas9	negative selection	7776438
233277638	233277661	2	+	27260156	NCIH2009	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.057690665533590035	[157]	[268,221,155]	-1	hSpCas9	negative selection	7833403
233263122	233263145	2	+	27260156	NCIH2009	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-1.5910914074576974	[28]	[7,26,3]	-9	hSpCas9	negative selection	7833404
233277589	233277612	2	+	27260156	NCIH2009	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.08927199540234976	[1081]	[1732,1530,1583]	1	hSpCas9	negative selection	7833405
233263209	233263232	2	+	27260156	NCIH2009	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.5093318709345267	[196]	[224,139,221]	-6	hSpCas9	negative selection	7897687
233272960	233272983	2	+	27260156	NCIH2009	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.36821341750868936	[529]	[1030,879,970]	5	hSpCas9	negative selection	7897688
233273034	233273057	2	-	27260156	NCIH2009	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	-0.11455304334668001	[590]	[846,731,724]	-1	hSpCas9	negative selection	7897689
233277638	233277661	2	+	27260156	NCIH1373	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.9454270051947928	[157]	[170,18,126,17]	-7	hSpCas9	negative selection	7954654
233263122	233263145	2	+	27260156	NCIH1373	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-1.313117510096479	[28]	[30,10,1,2]	-8	hSpCas9	negative selection	7954655
233277589	233277612	2	+	27260156	NCIH1373	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.6272521030485395	[1081]	[794,606,613,306]	-6	hSpCas9	negative selection	7954656
233263209	233263232	2	+	27260156	NCIH1373	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.8445496571075533	[196]	[100,12,190,51]	-7	hSpCas9	negative selection	8018938
233272960	233272983	2	+	27260156	NCIH1373	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.10093139636799886	[529]	[1258,479,473,114]	1	hSpCas9	negative selection	8018939
233273034	233273057	2	-	27260156	NCIH1373	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	-0.2963390196435873	[590]	[450,523,649,134]	-3	hSpCas9	negative selection	8018940
233277638	233277661	2	+	27260156	PATU8902	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	1.0586629534006813	[157]	[115,573,475,691]	9	hSpCas9	negative selection	8075905
233263122	233263145	2	+	27260156	PATU8902	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	1.6932485368567733	[28]	[99,363,2,82]	9	hSpCas9	negative selection	8075906
233277589	233277612	2	+	27260156	PATU8902	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.025301097134087014	[1081]	[1856,1574,985,1883]	0	hSpCas9	negative selection	8075907
233263209	233263232	2	+	27260156	PATU8902	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	0.26718049911797703	[196]	[286,342,233,499]	2	hSpCas9	negative selection	8140189
233272960	233272983	2	+	27260156	PATU8902	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.6324977071868669	[529]	[767,1170,1215,1433]	6	hSpCas9	negative selection	8140190
233273034	233273057	2	-	27260156	PATU8902	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.7305954620868975	[590]	[2407,852,1620,368]	7	hSpCas9	negative selection	8140191
233277638	233277661	2	+	27260156	PANC1	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.03296740085972805	[157]	[91,161,165,117]	0	hSpCas9	negative selection	8197156
233263122	233263145	2	+	27260156	PANC1	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-1.7917707894877637	[28]	[4,13,9,1]	-9	hSpCas9	negative selection	8197157
233277589	233277612	2	+	27260156	PANC1	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.1755734932075379	[1081]	[649,1533,799,497]	-3	hSpCas9	negative selection	8197158
233263209	233263232	2	+	27260156	PANC1	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	0.29380983278920125	[196]	[127,430,178,145]	5	hSpCas9	negative selection	8261440
233272960	233272983	2	+	27260156	PANC1	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.26742457564699246	[529]	[626,679,448,464]	4	hSpCas9	negative selection	8261441
233273034	233273057	2	-	27260156	PANC1	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	-0.015450271700539642	[590]	[455,721,507,380]	0	hSpCas9	negative selection	8261442
233277638	233277661	2	+	27260156	PANC0813	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.07120049156427832	[157]	[232,358,79,114]	1	hSpCas9	negative selection	8318407
233263122	233263145	2	+	27260156	PANC0813	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	0.48618781671906275	[28]	[36,29,41,78]	7	hSpCas9	negative selection	8318408
233277589	233277612	2	+	27260156	PANC0813	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.025269237536546862	[1081]	[1360,1449,1181,1189]	0	hSpCas9	negative selection	8318409
233263209	233263232	2	+	27260156	PANC0813	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	0.277833343119423	[196]	[329,343,192,259]	4	hSpCas9	negative selection	8382691
233272960	233272983	2	+	27260156	PANC0813	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.1324106621427742	[529]	[844,660,641,599]	2	hSpCas9	negative selection	8382692
233273034	233273057	2	-	27260156	PANC0813	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.16123589801656424	[590]	[1040,634,452,985]	2	hSpCas9	negative selection	8382693
233277638	233277661	2	+	27260156	RDES	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.36443529672365127	[157]	[242,200,224,263]	6	hSpCas9	negative selection	8439658
233263122	233263145	2	+	27260156	RDES	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-1.3518497464303314	[28]	[10,1,27,12]	-9	hSpCas9	negative selection	8439659
233277589	233277612	2	+	27260156	RDES	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.03420245299033531	[1081]	[1018,1280,1376,1468]	0	hSpCas9	negative selection	8439660
233263209	233263232	2	+	27260156	RDES	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.2332970894335431	[196]	[169,147,170,300]	-4	hSpCas9	negative selection	8503942
233272960	233272983	2	+	27260156	RDES	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.2893167980200951	[529]	[582,618,830,1016]	4	hSpCas9	negative selection	8503943
233273034	233273057	2	-	27260156	RDES	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	-0.05452541101872521	[590]	[495,625,776,756]	-1	hSpCas9	negative selection	8503944
233277638	233277661	2	+	27260156	PC3	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.2797264301183906	[157]	[94,297,251,161]	6	hSpCas9	negative selection	8560909
233263122	233263145	2	+	27260156	PC3	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.3415132096877471	[28]	[33,12,15,15]	-7	hSpCas9	negative selection	8560910
233277589	233277612	2	+	27260156	PC3	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.057424424434029175	[1081]	[705,1149,1655,896]	-1	hSpCas9	negative selection	8560911
233263209	233263232	2	+	27260156	PC3	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.22598973942596823	[196]	[143,129,192,206]	-5	hSpCas9	negative selection	8625193
233272960	233272983	2	+	27260156	PC3	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	-0.03439047054845046	[529]	[331,475,823,585]	-1	hSpCas9	negative selection	8625194
233273034	233273057	2	-	27260156	PC3	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.05346550268038158	[590]	[373,558,1108,647]	1	hSpCas9	negative selection	8625195
233277638	233277661	2	+	27260156	PATU8988T	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.5116460822178774	[157]	[143,176,309,235]	8	hSpCas9	negative selection	8682160
233263122	233263145	2	+	27260156	PATU8988T	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-1.2488739573143546	[28]	[20,7,4,12]	-9	hSpCas9	negative selection	8682161
233277589	233277612	2	+	27260156	PATU8988T	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.14971482174167838	[1081]	[640,917,850,1394]	-3	hSpCas9	negative selection	8682162
233263209	233263232	2	+	27260156	PATU8988T	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	0.02448073262531736	[196]	[299,66,186,209]	0	hSpCas9	negative selection	8746444
233272960	233272983	2	+	27260156	PATU8988T	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.7035091658955421	[529]	[1293,729,542,756]	9	hSpCas9	negative selection	8746445
233273034	233273057	2	-	27260156	PATU8988T	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.006761790307268312	[590]	[548,641,564,542]	0	hSpCas9	negative selection	8746446
233277638	233277661	2	+	27260156	T47D	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.06569430698532708	[157]	[172,200,233,159]	1	hSpCas9	negative selection	8803411
233263122	233263145	2	+	27260156	T47D	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.2663320555888298	[28]	[49,5,36,20]	-5	hSpCas9	negative selection	8803412
233277589	233277612	2	+	27260156	T47D	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.024690167018615483	[1081]	[1310,1198,1176,1274]	0	hSpCas9	negative selection	8803413
233263209	233263232	2	+	27260156	T47D	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.046186988375083615	[196]	[194,219,182,293]	-1	hSpCas9	negative selection	8867695
233272960	233272983	2	+	27260156	T47D	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.265221686269984	[529]	[820,734,651,762]	5	hSpCas9	negative selection	8867696
233273034	233273057	2	-	27260156	T47D	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.06057330623401608	[590]	[704,639,734,800]	1	hSpCas9	negative selection	8867697
233277638	233277661	2	+	27260156	SU8686	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.22147378167548748	[157]	[114,117,123,192]	-4	hSpCas9	negative selection	8924662
233263122	233263145	2	+	27260156	SU8686	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.23705423307321016	[28]	[9,17,7,70]	-4	hSpCas9	negative selection	8924663
233277589	233277612	2	+	27260156	SU8686	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.10095757332576416	[1081]	[942,849,1033,1230]	-2	hSpCas9	negative selection	8924664
233263209	233263232	2	+	27260156	SU8686	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.736202310298584	[196]	[90,115,98,173]	-8	hSpCas9	negative selection	8988946
233272960	233272983	2	+	27260156	SU8686	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.029135788527065998	[529]	[441,468,632,634]	0	hSpCas9	negative selection	8988947
233273034	233273057	2	-	27260156	SU8686	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.13674075047118117	[590]	[557,496,836,727]	2	hSpCas9	negative selection	8988948
233277638	233277661	2	+	27260156	SKES1	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	0.3356352838650749	[157]	[264,230,209,110]	7	hSpCas9	negative selection	9045913
233263122	233263145	2	+	27260156	SKES1	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.7557877501176016	[28]	[9,12,18,23]	-9	hSpCas9	negative selection	9045914
233277589	233277612	2	+	27260156	SKES1	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.04057050232589754	[1081]	[1081,1096,992,1027]	-1	hSpCas9	negative selection	9045915
233263209	233263232	2	+	27260156	SKES1	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.15499478745466622	[196]	[182,179,180,162]	-3	hSpCas9	negative selection	9110197
233272960	233272983	2	+	27260156	SKES1	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.18125398371407464	[529]	[591,889,546,418]	4	hSpCas9	negative selection	9110198
233273034	233273057	2	-	27260156	SKES1	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.1105892309406129	[590]	[709,733,552,572]	2	hSpCas9	negative selection	9110199
233277638	233277661	2	+	27260156	TOV112D	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.032184646763187885	[157]	[150,197,230,51]	0	hSpCas9	negative selection	9167164
233263122	233263145	2	+	27260156	TOV112D	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-2.1805230393733375	[28]	[21,1,0,0]	-9	hSpCas9	negative selection	9167165
233277589	233277612	2	+	27260156	TOV112D	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.020651783700658566	[1081]	[1014,1341,973,1004]	0	hSpCas9	negative selection	9167166
233263209	233263232	2	+	27260156	TOV112D	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	0.04888406643027099	[196]	[149,173,307,172]	1	hSpCas9	negative selection	9231448
233272960	233272983	2	+	27260156	TOV112D	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	-0.028739895976820307	[529]	[391,695,650,377]	0	hSpCas9	negative selection	9231449
233273034	233273057	2	-	27260156	TOV112D	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.12414459838758629	[590]	[700,829,577,523]	2	hSpCas9	negative selection	9231450
233277638	233277661	2	+	27260156	TC71	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.06618773938551259	[157]	[177,144,158,164]	-2	hSpCas9	negative selection	9288415
233263122	233263145	2	+	27260156	TC71	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	-0.0857414801304941	[28]	[0,18,32,66]	-2	hSpCas9	negative selection	9288416
233277589	233277612	2	+	27260156	TC71	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	-0.20954713491863897	[1081]	[851,938,1119,1106]	-5	hSpCas9	negative selection	9288417
233263209	233263232	2	+	27260156	TC71	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.19966163656637814	[196]	[170,179,172,213]	-5	hSpCas9	negative selection	9352699
233272960	233272983	2	+	27260156	TC71	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.15419924790600353	[529]	[501,704,618,710]	4	hSpCas9	negative selection	9352700
233273034	233273057	2	-	27260156	TC71	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.23544721072377872	[590]	[780,606,836,754]	6	hSpCas9	negative selection	9352701
233277638	233277661	2	+	27260156	TC32	viability	TGGACCGCAGGGTTAAGCTTTGG	ATG16L1	ENSG00000085978	-0.030343852651436798	[157]	[146,71,139,246]	0	hSpCas9	negative selection	9409666
233263122	233263145	2	+	27260156	TC32	viability	CAATTTAGTCCCGGACATGATGG	ATG16L1	ENSG00000085978	0.055050456113452384	[28]	[28,31,17,28]	1	hSpCas9	negative selection	9409667
233277589	233277612	2	+	27260156	TC32	viability	AACGCTGTGCAGTTCAGTCCAGG	ATG16L1	ENSG00000085978	0.04398058549087125	[1081]	[1061,744,1363,1131]	0	hSpCas9	negative selection	9409668
233263209	233263232	2	+	27260156	TC32	viability	ACTGAATTACACAAGAAACGTGG	ATG16L1	ENSG00000085978	-0.48602581065687733	[196]	[109,99,166,166]	-7	hSpCas9	negative selection	9473950
233272960	233272983	2	+	27260156	TC32	viability	TTCCAGGGATGATGACATTGAGG	ATG16L1	ENSG00000085978	0.19829736023946504	[529]	[612,347,783,626]	3	hSpCas9	negative selection	9473951
233273034	233273057	2	-	27260156	TC32	viability	TTACGTGGCTGCTCTGCTGATGG	ATG16L1	ENSG00000085978	0.08097623553376737	[590]	[523,418,759,721]	1	hSpCas9	negative selection	9473952
233251858	233251881	2	-	27869803	HPAFII	viability after 27 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.0037067955402823004	[245]	[110,143,NaN]	0	hSpCas9	negative selection	9573996
233263181	233263204	2	+	27869803	HPAFII	viability after 27 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	-0.11339360401904319	[236]	[94,131,NaN]	-1	hSpCas9	negative selection	9573997
233264015	233264038	2	+	27869803	HPAFII	viability after 27 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	-0.30039466049690916	[203]	[85,87,NaN]	-2	hSpCas9	negative selection	9573998
233264910	233264933	2	+	27869803	HPAFII	viability after 27 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	0.3892183665166864	[107]	[39,102,NaN]	3	hSpCas9	negative selection	9573999
233269995	233270018	2	+	27869803	HPAFII	viability after 27 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.8744419448505811	[180]	[126,213,NaN]	7	hSpCas9	negative selection	9574000
233274728	233274751	2	-	27869803	HPAFII	viability after 27 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.578769397975998	[617]	[517,457,NaN]	5	hSpCas9	negative selection	9574001
233251858	233251881	2	-	27869803	HPAFII	viability after 15 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.8622698128322102	[245]	[360,554,NaN]	8	hSpCas9	negative selection	9656445
233263181	233263204	2	+	27869803	HPAFII	viability after 15 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	0.11348701014447349	[236]	[343,232,NaN]	1	hSpCas9	negative selection	9656446
233264015	233264038	2	+	27869803	HPAFII	viability after 15 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	0.31558235721692657	[203]	[307,250,NaN]	3	hSpCas9	negative selection	9656447
233264910	233264933	2	+	27869803	HPAFII	viability after 15 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	0.2289758494638442	[107]	[156,122,NaN]	2	hSpCas9	negative selection	9656448
233269995	233270018	2	+	27869803	HPAFII	viability after 15 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.6441744181828976	[180]	[451,211,NaN]	7	hSpCas9	negative selection	9656449
233274728	233274751	2	-	27869803	HPAFII	viability after 15 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.42888187338005346	[617]	[1067,785,NaN]	5	hSpCas9	negative selection	9656450
233251858	233251881	2	-	27869803	ASPC1	viability after 36 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.7796524001148561	[788]	[635,534,303]	7	hSpCas9	negative selection	9738894
233263181	233263204	2	+	27869803	ASPC1	viability after 36 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	0.711188491689589	[510]	[357,307,229]	7	hSpCas9	negative selection	9738895
233264015	233264038	2	+	27869803	ASPC1	viability after 36 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	0.38274371777523103	[497]	[205,277,197]	4	hSpCas9	negative selection	9738896
233264910	233264933	2	+	27869803	ASPC1	viability after 36 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	-1.7444086021713512	[248]	[12,41,21]	-9	hSpCas9	negative selection	9738897
233269995	233270018	2	+	27869803	ASPC1	viability after 36 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.8260530907507788	[607]	[488,470,217]	7	hSpCas9	negative selection	9738898
233274728	233274751	2	-	27869803	ASPC1	viability after 36 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.7413322354817298	[1595]	[498,2045,339]	7	hSpCas9	negative selection	9738899
233251858	233251881	2	-	27869803	PATU8988S	viability after 35 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.5434322866227502	[606]	[486,224,NaN]	6	hSpCas9	negative selection	9821343
233263181	233263204	2	+	27869803	PATU8988S	viability after 35 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	0.5535824756858747	[425]	[172,330,NaN]	6	hSpCas9	negative selection	9821344
233264015	233264038	2	+	27869803	PATU8988S	viability after 35 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	0.9942079834491722	[373]	[321,277,NaN]	8	hSpCas9	negative selection	9821345
233264910	233264933	2	+	27869803	PATU8988S	viability after 35 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	0.931057283290695	[210]	[174,148,NaN]	8	hSpCas9	negative selection	9821346
233269995	233270018	2	+	27869803	PATU8988S	viability after 35 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.15975664742221649	[488]	[222,216,NaN]	1	hSpCas9	negative selection	9821347
233274728	233274751	2	-	27869803	PATU8988S	viability after 35 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.1446369083596859	[1262]	[480,643,NaN]	1	hSpCas9	negative selection	9821348
233251858	233251881	2	-	27869803	PATU8988S	viability after 31 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.5953892565690709	[606]	[410,307,NaN]	7	hSpCas9	negative selection	9903792
233263181	233263204	2	+	27869803	PATU8988S	viability after 31 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	0.6268527709219882	[425]	[183,361,NaN]	7	hSpCas9	negative selection	9903793
233264015	233264038	2	+	27869803	PATU8988S	viability after 31 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	0.8603691141207387	[373]	[202,356,NaN]	8	hSpCas9	negative selection	9903794
233264910	233264933	2	+	27869803	PATU8988S	viability after 31 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	0.841431020940933	[210]	[126,180,NaN]	8	hSpCas9	negative selection	9903795
233269995	233270018	2	+	27869803	PATU8988S	viability after 31 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	-0.04839496539184793	[488]	[155,229,NaN]	0	hSpCas9	negative selection	9903796
233274728	233274751	2	-	27869803	PATU8988S	viability after 31 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.08429751030327792	[1262]	[514,557,NaN]	1	hSpCas9	negative selection	9903797
233251858	233251881	2	-	27869803	HPAFII	viability after 35 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.18743253331752732	[245]	[122,162,NaN]	1	hSpCas9	negative selection	9986241
233263181	233263204	2	+	27869803	HPAFII	viability after 35 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	-0.47575594222325146	[236]	[50,125,NaN]	-3	hSpCas9	negative selection	9986242
233264015	233264038	2	+	27869803	HPAFII	viability after 35 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	-0.423624306699426	[203]	[68,85,NaN]	-3	hSpCas9	negative selection	9986243
233264910	233264933	2	+	27869803	HPAFII	viability after 35 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	-0.6294106933184618	[107]	[16,55,NaN]	-4	hSpCas9	negative selection	9986244
233269995	233270018	2	+	27869803	HPAFII	viability after 35 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.5269823409719916	[180]	[76,193,NaN]	3	hSpCas9	negative selection	9986245
233274728	233274751	2	-	27869803	HPAFII	viability after 35 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.7349001721060258	[617]	[602,427,NaN]	5	hSpCas9	negative selection	9986246
233251858	233251881	2	-	27869803	HPAFII	viability after 31 days	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.07502361835410913	[245]	[154,134,NaN]	0	hSpCas9	negative selection	10068690
233263181	233263204	2	+	27869803	HPAFII	viability after 31 days	ACTGAGGATTAAGCACCAAGAGG	ATG16L1	ENSG00000085978	-0.20077077400331364	[236]	[64,170,NaN]	-1	hSpCas9	negative selection	10068691
233264015	233264038	2	+	27869803	HPAFII	viability after 31 days	GAATAACCAAATGCAGCGGAAGG	ATG16L1	ENSG00000085978	-0.20160121971124062	[203]	[111,85,NaN]	-1	hSpCas9	negative selection	10068692
233264910	233264933	2	+	27869803	HPAFII	viability after 31 days	GACTATCTCTGACCTGGAGACGG	ATG16L1	ENSG00000085978	0.06359373543412983	[107]	[70,54,NaN]	0	hSpCas9	negative selection	10068693
233269995	233270018	2	+	27869803	HPAFII	viability after 31 days	CCAACAGGAGGCGGCAAGCCCGG	ATG16L1	ENSG00000085978	0.9481825793993266	[180]	[139,256,NaN]	7	hSpCas9	negative selection	10068694
233274728	233274751	2	-	27869803	HPAFII	viability after 31 days	CTCACTTCTTTACCAGAACCAGG	ATG16L1	ENSG00000085978	0.6831641499056813	[617]	[520,595,NaN]	5	hSpCas9	negative selection	10068695
233273019	233273042	2	-	28162770	P31FUJ	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-0.383219046967477	[201]	[181]	-3	hSpCas9	negative selection	10115209
233293271	233293294	2	+	28162770	P31FUJ	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-1.7887648334129824	[196]	[66]	-8	hSpCas9	negative selection	10115210
233251858	233251881	2	-	28162770	P31FUJ	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.12999139883060323	[175]	[188]	-1	hSpCas9	negative selection	10115211
233251871	233251894	2	+	28162770	P31FUJ	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	0.14847131364873767	[280]	[365]	1	hSpCas9	negative selection	10115212
233277626	233277649	2	-	28162770	P31FUJ	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	-0.8917652865793113	[89]	[56]	-6	hSpCas9	negative selection	10115213
233292131	233292154	2	+	28162770	P31FUJ	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	-0.30347895038440204	[250]	[238]	-3	hSpCas9	negative selection	10115214
233292391	233292414	2	-	28162770	P31FUJ	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	0.2688449752141937	[795]	[1126]	3	hSpCas9	negative selection	10115215
233293336	233293359	2	+	28162770	P31FUJ	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	0.03317948546975219	[162]	[195]	0	hSpCas9	negative selection	10115216
233277618	233277641	2	+	28162770	P31FUJ	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	0.7026933960988462	[525]	[1005]	7	hSpCas9	negative selection	10115217
233293260	233293283	2	+	28162770	P31FUJ	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	0.6447568590840913	[423]	[778]	7	hSpCas9	negative selection	10115218
233273019	233273042	2	-	28162770	TF1	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	NaN	[NaN]	[162]	1	hSpCas9	negative selection	10284575
233293271	233293294	2	+	28162770	TF1	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	NaN	[NaN]	[75]	1	hSpCas9	negative selection	10284576
233251858	233251881	2	-	28162770	TF1	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	NaN	[NaN]	[98]	1	hSpCas9	negative selection	10284577
233251871	233251894	2	+	28162770	TF1	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	NaN	[NaN]	[29]	1	hSpCas9	negative selection	10284578
233277626	233277649	2	-	28162770	TF1	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	NaN	[NaN]	[16]	1	hSpCas9	negative selection	10284579
233292131	233292154	2	+	28162770	TF1	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	NaN	[NaN]	[241]	1	hSpCas9	negative selection	10284580
233292391	233292414	2	-	28162770	TF1	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	NaN	[NaN]	[538]	1	hSpCas9	negative selection	10284581
233293336	233293359	2	+	28162770	TF1	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	NaN	[NaN]	[160]	1	hSpCas9	negative selection	10284582
233277618	233277641	2	+	28162770	TF1	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	NaN	[NaN]	[267]	1	hSpCas9	negative selection	10284583
233293260	233293283	2	+	28162770	TF1	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	NaN	[NaN]	[342]	1	hSpCas9	negative selection	10284584
233273019	233273042	2	-	28162770	SKM1	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.43175489422377755	[51]	[123]	4	hSpCas9	negative selection	10453941
233293271	233293294	2	+	28162770	SKM1	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-1.3215727075125172	[40]	[28]	-7	hSpCas9	negative selection	10453942
233251858	233251881	2	-	28162770	SKM1	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.45810622117072974	[48]	[118]	4	hSpCas9	negative selection	10453943
233251871	233251894	2	+	28162770	SKM1	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	0.36961837451962576	[87]	[200]	3	hSpCas9	negative selection	10453944
233277626	233277649	2	-	28162770	SKM1	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	0.6519294903104067	[26]	[74]	6	hSpCas9	negative selection	10453945
233292131	233292154	2	+	28162770	SKM1	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	-0.35361477415022813	[72]	[100]	-3	hSpCas9	negative selection	10453946
233292391	233292414	2	-	28162770	SKM1	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	0.5126936929392345	[179]	[453]	5	hSpCas9	negative selection	10453947
233293336	233293359	2	+	28162770	SKM1	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	0.347923303420307	[31]	[71]	3	hSpCas9	negative selection	10453948
233277618	233277641	2	+	28162770	SKM1	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	0.4174642366733836	[143]	[339]	4	hSpCas9	negative selection	10453949
233293260	233293283	2	+	28162770	SKM1	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	0.1779983019779945	[85]	[171]	1	hSpCas9	negative selection	10453950
233273019	233273042	2	-	28162770	SKM1	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.43175489422377755	[51]	[123]	4	hSpCas9	negative selection	10623307
233293271	233293294	2	+	28162770	SKM1	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-1.3215727075125172	[40]	[28]	-7	hSpCas9	negative selection	10623308
233251858	233251881	2	-	28162770	SKM1	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.45810622117072974	[48]	[118]	4	hSpCas9	negative selection	10623309
233251871	233251894	2	+	28162770	SKM1	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	0.36961837451962576	[87]	[200]	3	hSpCas9	negative selection	10623310
233277626	233277649	2	-	28162770	SKM1	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	0.6519294903104067	[26]	[74]	6	hSpCas9	negative selection	10623311
233292131	233292154	2	+	28162770	SKM1	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	-0.35361477415022813	[72]	[100]	-3	hSpCas9	negative selection	10623312
233292391	233292414	2	-	28162770	SKM1	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	0.5126936929392345	[179]	[453]	5	hSpCas9	negative selection	10623313
233293336	233293359	2	+	28162770	SKM1	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	0.347923303420307	[31]	[71]	3	hSpCas9	negative selection	10623314
233277618	233277641	2	+	28162770	SKM1	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	0.4174642366733836	[143]	[339]	4	hSpCas9	negative selection	10623315
233293260	233293283	2	+	28162770	SKM1	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	0.1779983019779945	[85]	[171]	1	hSpCas9	negative selection	10623316
233273019	233273042	2	-	28162770	PL21	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-1.446750635375038	[237]	[37]	-7	hSpCas9	negative selection	10792673
233293271	233293294	2	+	28162770	PL21	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-2.865949575968452	[133]	[7]	-9	hSpCas9	negative selection	10792674
233251858	233251881	2	-	28162770	PL21	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.10401377867006609	[241]	[97]	0	hSpCas9	negative selection	10792675
233251871	233251894	2	+	28162770	PL21	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	-1.4722857274821757	[254]	[39]	-7	hSpCas9	negative selection	10792676
233277626	233277649	2	-	28162770	PL21	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	-4.458071868262475	[100]	[1]	-9	hSpCas9	negative selection	10792677
233292131	233292154	2	+	28162770	PL21	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	1.2698485863007245	[201]	[211]	9	hSpCas9	negative selection	10792678
233292391	233292414	2	-	28162770	PL21	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	0.20013961448932016	[587]	[293]	1	hSpCas9	negative selection	10792679
233293336	233293359	2	+	28162770	PL21	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	0.8539639733552804	[149]	[117]	7	hSpCas9	negative selection	10792680
233277618	233277641	2	+	28162770	PL21	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	-0.6101565828804064	[490]	[139]	-4	hSpCas9	negative selection	10792681
233293260	233293283	2	+	28162770	PL21	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	0.09242579718906696	[277]	[128]	0	hSpCas9	negative selection	10792682
233273019	233273042	2	-	28162770	P31FUJ	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-0.383219046967477	[201]	[181]	-3	hSpCas9	negative selection	10962039
233293271	233293294	2	+	28162770	P31FUJ	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-1.7887648334129824	[196]	[66]	-8	hSpCas9	negative selection	10962040
233251858	233251881	2	-	28162770	P31FUJ	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.12999139883060323	[175]	[188]	-1	hSpCas9	negative selection	10962041
233251871	233251894	2	+	28162770	P31FUJ	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	0.14847131364873767	[280]	[365]	1	hSpCas9	negative selection	10962042
233277626	233277649	2	-	28162770	P31FUJ	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	-0.8917652865793113	[89]	[56]	-6	hSpCas9	negative selection	10962043
233292131	233292154	2	+	28162770	P31FUJ	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	-0.30347895038440204	[250]	[238]	-3	hSpCas9	negative selection	10962044
233292391	233292414	2	-	28162770	P31FUJ	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	0.2688449752141937	[795]	[1126]	3	hSpCas9	negative selection	10962045
233293336	233293359	2	+	28162770	P31FUJ	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	0.03317948546975219	[162]	[195]	0	hSpCas9	negative selection	10962046
233277618	233277641	2	+	28162770	P31FUJ	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	0.7026933960988462	[525]	[1005]	7	hSpCas9	negative selection	10962047
233293260	233293283	2	+	28162770	P31FUJ	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	0.6447568590840913	[423]	[778]	7	hSpCas9	negative selection	10962048
233273019	233273042	2	-	28162770	OCIAML5	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-1.4172658167637233	[144]	[97]	-7	hSpCas9	negative selection	11131405
233293271	233293294	2	+	28162770	OCIAML5	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-1.4285674928369572	[84]	[56]	-7	hSpCas9	negative selection	11131406
233251858	233251881	2	-	28162770	OCIAML5	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.5590898496727637	[150]	[184]	-4	hSpCas9	negative selection	11131407
233251871	233251894	2	+	28162770	OCIAML5	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	-1.7963571382777095	[126]	[65]	-7	hSpCas9	negative selection	11131408
233277626	233277649	2	-	28162770	OCIAML5	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	-0.34016753233256414	[53]	[76]	-2	hSpCas9	negative selection	11131409
233292131	233292154	2	+	28162770	OCIAML5	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	-0.19916524148626516	[158]	[249]	-1	hSpCas9	negative selection	11131410
233292391	233292414	2	-	28162770	OCIAML5	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	0.416729810371296	[353]	[852]	3	hSpCas9	negative selection	11131411
233293336	233293359	2	+	28162770	OCIAML5	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	0.8483731472770952	[79]	[259]	7	hSpCas9	negative selection	11131412
233277618	233277641	2	+	28162770	OCIAML5	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	-0.0305232059274263	[317]	[561]	0	hSpCas9	negative selection	11131413
233293260	233293283	2	+	28162770	OCIAML5	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	0.46126550033498015	[201]	[501]	4	hSpCas9	negative selection	11131414
233273019	233273042	2	-	28162770	EOL1	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-0.6491874737273673	[383]	[128]	-5	hSpCas9	negative selection	11300771
233293271	233293294	2	+	28162770	EOL1	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-1.8173840754890211	[193]	[28]	-8	hSpCas9	negative selection	11300772
233251858	233251881	2	-	28162770	EOL1	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.03284605705160554	[366]	[188]	0	hSpCas9	negative selection	11300773
233251871	233251894	2	+	28162770	EOL1	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	-0.07287368432768893	[558]	[279]	0	hSpCas9	negative selection	11300774
233277626	233277649	2	-	28162770	EOL1	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	-0.22467823720394164	[172]	[77]	-2	hSpCas9	negative selection	11300775
233292131	233292154	2	+	28162770	EOL1	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	0.4125167933032295	[404]	[283]	4	hSpCas9	negative selection	11300776
233292391	233292414	2	-	28162770	EOL1	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	0.17281882473258814	[883]	[524]	1	hSpCas9	negative selection	11300777
233293336	233293359	2	+	28162770	EOL1	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	0.7568203258324682	[163]	[145]	6	hSpCas9	negative selection	11300778
233277618	233277641	2	+	28162770	EOL1	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	0.7848690569963426	[530]	[481]	7	hSpCas9	negative selection	11300779
233293260	233293283	2	+	28162770	EOL1	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	0.0100171137598839	[425]	[225]	0	hSpCas9	negative selection	11300780
233273019	233273042	2	-	28162770	MOLM13	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-0.2900721451135975	[322]	[190]	-2	hSpCas9	negative selection	11470137
233293271	233293294	2	+	28162770	MOLM13	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-2.978366848344985	[217]	[19]	-8	hSpCas9	negative selection	11470138
233251858	233251881	2	-	28162770	MOLM13	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.6273675955517755	[307]	[343]	5	hSpCas9	negative selection	11470139
233251871	233251894	2	+	28162770	MOLM13	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	0.07448189823727774	[330]	[251]	0	hSpCas9	negative selection	11470140
233277626	233277649	2	-	28162770	MOLM13	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	-0.35213195234918593	[142]	[80]	-2	hSpCas9	negative selection	11470141
233292131	233292154	2	+	28162770	MOLM13	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	1.1290140541019695	[288]	[456]	8	hSpCas9	negative selection	11470142
233292391	233292414	2	-	28162770	MOLM13	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	-0.23096408570456162	[908]	[559]	-1	hSpCas9	negative selection	11470143
233293336	233293359	2	+	28162770	MOLM13	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	-0.2579356550164268	[214]	[129]	-1	hSpCas9	negative selection	11470144
233277618	233277641	2	+	28162770	MOLM13	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	-0.4753415225229237	[597]	[310]	-3	hSpCas9	negative selection	11470145
233293260	233293283	2	+	28162770	MOLM13	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	1.041852883316478	[394]	[587]	7	hSpCas9	negative selection	11470146
233273019	233273042	2	-	28162770	HEL	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-1.1180735041202168	[304]	[89]	-6	hSpCas9	negative selection	11639503
233293271	233293294	2	+	28162770	HEL	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-1.4228495096272198	[179]	[42]	-7	hSpCas9	negative selection	11639504
233251858	233251881	2	-	28162770	HEL	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.6486394334400413	[243]	[244]	5	hSpCas9	negative selection	11639505
233251871	233251894	2	+	28162770	HEL	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	-0.28864455592525284	[348]	[182]	-2	hSpCas9	negative selection	11639506
233277626	233277649	2	-	28162770	HEL	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	0.7663135171188896	[122]	[133]	6	hSpCas9	negative selection	11639507
233292131	233292154	2	+	28162770	HEL	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	0.5252452689819164	[357]	[329]	4	hSpCas9	negative selection	11639508
233292391	233292414	2	-	28162770	HEL	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	-0.038517329579561554	[634]	[395]	0	hSpCas9	negative selection	11639509
233293336	233293359	2	+	28162770	HEL	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	1.0991171266601003	[128]	[176]	8	hSpCas9	negative selection	11639510
233277618	233277641	2	+	28162770	HEL	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	0.5538789006102331	[451]	[424]	5	hSpCas9	negative selection	11639511
233293260	233293283	2	+	28162770	HEL	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	0.38760962425190926	[363]	[304]	3	hSpCas9	negative selection	11639512
233273019	233273042	2	-	28162770	MV411	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-0.767829205870535	[189]	[93]	-5	hSpCas9	negative selection	11808869
233293271	233293294	2	+	28162770	MV411	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-2.8842681284290466	[148]	[16]	-9	hSpCas9	negative selection	11808870
233251858	233251881	2	-	28162770	MV411	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.2336974941564728	[210]	[208]	2	hSpCas9	negative selection	11808871
233251871	233251894	2	+	28162770	MV411	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	-1.4754528581717081	[339]	[102]	-7	hSpCas9	negative selection	11808872
233277626	233277649	2	-	28162770	MV411	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	-0.25006210868804146	[95]	[67]	-2	hSpCas9	negative selection	11808873
233292131	233292154	2	+	28162770	MV411	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	-0.16036837926499264	[198]	[149]	-1	hSpCas9	negative selection	11808874
233292391	233292414	2	-	28162770	MV411	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	-0.35992749699052484	[648]	[425]	-3	hSpCas9	negative selection	11808875
233293336	233293359	2	+	28162770	MV411	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	1.6755312028870657	[109]	[295]	9	hSpCas9	negative selection	11808876
233277618	233277641	2	+	28162770	MV411	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	0.5538645521299499	[392]	[485]	5	hSpCas9	negative selection	11808877
233293260	233293283	2	+	28162770	MV411	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	-0.6843277134647726	[350]	[183]	-5	hSpCas9	negative selection	11808878
233273019	233273042	2	-	28162770	MONOMAC1	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	0.42856763815894844	[139]	[215]	4	hSpCas9	negative selection	11978235
233293271	233293294	2	+	28162770	MONOMAC1	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-0.9764377075461562	[114]	[66]	-6	hSpCas9	negative selection	11978236
233251858	233251881	2	-	28162770	MONOMAC1	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	0.16677532886411683	[128]	[165]	1	hSpCas9	negative selection	11978237
233251871	233251894	2	+	28162770	MONOMAC1	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	-0.1212693394415888	[203]	[214]	-1	hSpCas9	negative selection	11978238
233277626	233277649	2	-	28162770	MONOMAC1	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	-1.4283623931660092	[53]	[22]	-8	hSpCas9	negative selection	11978239
233292131	233292154	2	+	28162770	MONOMAC1	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	0.38792565366160237	[145]	[218]	4	hSpCas9	negative selection	11978240
233292391	233292414	2	-	28162770	MONOMAC1	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	-0.36383284176446984	[402]	[358]	-3	hSpCas9	negative selection	11978241
233293336	233293359	2	+	28162770	MONOMAC1	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	0.9507167733841384	[50]	[112]	8	hSpCas9	negative selection	11978242
233277618	233277641	2	+	28162770	MONOMAC1	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	-0.007559048195840745	[284]	[324]	0	hSpCas9	negative selection	11978243
233293260	233293283	2	+	28162770	MONOMAC1	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	0.13101735062465003	[187]	[235]	1	hSpCas9	negative selection	11978244
233273019	233273042	2	-	28162770	OCIAML2	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-0.33938529196390865	[41]	[183]	-3	hSpCas9	negative selection	12147601
233293271	233293294	2	+	28162770	OCIAML2	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-2.4092292805780176	[22]	[23]	-8	hSpCas9	negative selection	12147602
233251858	233251881	2	-	28162770	OCIAML2	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.06587529922517826	[43]	[232]	0	hSpCas9	negative selection	12147603
233251871	233251894	2	+	28162770	OCIAML2	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	0.31017167777412646	[46]	[322]	3	hSpCas9	negative selection	12147604
233277626	233277649	2	-	28162770	OCIAML2	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	0.03716481495653512	[15]	[90]	0	hSpCas9	negative selection	12147605
233292131	233292154	2	+	28162770	OCIAML2	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	-0.06254508660508429	[51]	[275]	0	hSpCas9	negative selection	12147606
233292391	233292414	2	-	28162770	OCIAML2	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	0.3025093814775299	[127]	[874]	3	hSpCas9	negative selection	12147607
233293336	233293359	2	+	28162770	OCIAML2	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	-1.037670417966055	[19]	[53]	-6	hSpCas9	negative selection	12147608
233277618	233277641	2	+	28162770	OCIAML2	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	0.7859849103954488	[60]	[582]	7	hSpCas9	negative selection	12147609
233293260	233293283	2	+	28162770	OCIAML2	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	0.4561603278040621	[47]	[364]	4	hSpCas9	negative selection	12147610
233273019	233273042	2	-	28162770	OCIAML3	viability	GCTGATGGCTCGCACAGGAGAGG	ATG16L1	ENSG00000085978	-1.4013625623817672	[76]	[87]	-7	hSpCas9	negative selection	12316967
233293271	233293294	2	+	28162770	OCIAML3	viability	CGTGGCGGCAGGCTCTGCTGAGG	ATG16L1	ENSG00000085978	-2.093578649814675	[40]	[28]	-8	hSpCas9	negative selection	12316968
233251858	233251881	2	-	28162770	OCIAML3	viability	GAGATGTGGCGCTTCCAGCGGGG	ATG16L1	ENSG00000085978	-0.34736767274103797	[58]	[139]	-3	hSpCas9	negative selection	12316969
233251871	233251894	2	+	28162770	OCIAML3	viability	GCCACATCTCGGAGCAACTGAGG	ATG16L1	ENSG00000085978	0.5952179170770856	[65]	[300]	5	hSpCas9	negative selection	12316970
233277626	233277649	2	-	28162770	OCIAML3	viability	CCTGCGGTCCATGCCTCCAGTGG	ATG16L1	ENSG00000085978	-1.7956415014938139	[22]	[19]	-8	hSpCas9	negative selection	12316971
233292131	233292154	2	+	28162770	OCIAML3	viability	AGAGAGCATAGTTCGAGAGATGG	ATG16L1	ENSG00000085978	-0.009045139603006846	[56]	[170]	0	hSpCas9	negative selection	12316972
233292391	233292414	2	-	28162770	OCIAML3	viability	TCAGAGCCGCACTTGAACCCAGG	ATG16L1	ENSG00000085978	-0.6675887727052707	[180]	[343]	-5	hSpCas9	negative selection	12316973
233293336	233293359	2	+	28162770	OCIAML3	viability	AGGTTCTTTCAAAGCAGCACAGG	ATG16L1	ENSG00000085978	-0.4593581136293814	[45]	[100]	-4	hSpCas9	negative selection	12316974
233277618	233277641	2	+	28162770	OCIAML3	viability	GTTACTGGCCACTGGAGGCATGG	ATG16L1	ENSG00000085978	0.711494906650088	[105]	[523]	6	hSpCas9	negative selection	12316975
233293260	233293283	2	+	28162770	OCIAML3	viability	GATGGCAGTTACGTGGCGGCAGG	ATG16L1	ENSG00000085978	0.11124909411470474	[91]	[299]	1	hSpCas9	negative selection	12316976