| 63671304 | 63671327 | 11 | + | 26472758 | Jiyoye | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | -0.017322447022036724 | [152] | [113] | 0 | hSpCas9 | negative selection | 11925 | 63659201 | 63659224 | 11 | + | 26472758 | Jiyoye | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | 0.3149168736538848 | [112] | [105] | 2 | hSpCas9 | negative selection | 11926 | 63631312 | 63631335 | 11 | - | 26472758 | Jiyoye | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | 0.40717538150587274 | [0] | [0] | 3 | hSpCas9 | negative selection | 11927 | 63631229 | 63631252 | 11 | + | 26472758 | Jiyoye | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | 1.2781889407857951 | [75] | [138] | 7 | hSpCas9 | negative selection | 11928 | 63671289 | 63671312 | 11 | - | 26472758 | Jiyoye | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | 0.8303868122304172 | [87] | [117] | 6 | hSpCas9 | negative selection | 11929 | 63659160 | 63659183 | 11 | - | 26472758 | Jiyoye | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | 0.7415944205764329 | [22] | [28] | 5 | hSpCas9 | negative selection | 11930 | 63631362 | 63631385 | 11 | - | 26472758 | Jiyoye | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | 0.25779775746764666 | [182] | [164] | 2 | hSpCas9 | negative selection | 11931 | 63659241 | 63659264 | 11 | - | 26472758 | Jiyoye | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | 0.3133932351852563 | [142] | [133] | 2 | hSpCas9 | negative selection | 11932 | 63671304 | 63671327 | 11 | + | 26472758 | KBM7 | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | -0.5014357674869643 | [557,303] | [119,156] | -4 | hSpCas9 | negative selection | 203043 | 63659201 | 63659224 | 11 | + | 26472758 | KBM7 | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | 0.1425777769873362 | [571,619] | [290,330] | 1 | hSpCas9 | negative selection | 203044 | 63631312 | 63631335 | 11 | - | 26472758 | KBM7 | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | -2.3448170512913524 | [96,62] | [1,11] | -9 | hSpCas9 | negative selection | 203045 | 63631229 | 63631252 | 11 | + | 26472758 | KBM7 | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | -1.2187560742523995 | [414,362] | [41,110] | -7 | hSpCas9 | negative selection | 203046 | 63671289 | 63671312 | 11 | - | 26472758 | KBM7 | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | 0.041076206007189336 | [657,470] | [320,223] | 0 | hSpCas9 | negative selection | 203047 | 63659160 | 63659183 | 11 | - | 26472758 | KBM7 | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | 0.6341034433924437 | [20,71] | [35,35] | 7 | hSpCas9 | negative selection | 203048 | 63631362 | 63631385 | 11 | - | 26472758 | KBM7 | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | -0.02656603726939087 | [549,477] | [241,231] | 0 | hSpCas9 | negative selection | 203049 | 63659241 | 63659264 | 11 | - | 26472758 | KBM7 | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | 0.503340653769776 | [661,567] | [612,225] | 5 | hSpCas9 | negative selection | 203050 | 63671304 | 63671327 | 11 | + | 26472758 | Raji | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | 0.12466152680543507 | [165] | [41] | 1 | hSpCas9 | negative selection | 394161 | 63659201 | 63659224 | 11 | + | 26472758 | Raji | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | 0.009081461761795528 | [333] | [77] | 0 | hSpCas9 | negative selection | 394162 | 63631312 | 63631335 | 11 | - | 26472758 | Raji | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | -1.2145445595137634 | [9] | [0] | -7 | hSpCas9 | negative selection | 394163 | 63631229 | 63631252 | 11 | + | 26472758 | Raji | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | -0.008093682046336426 | [116] | [26] | 0 | hSpCas9 | negative selection | 394164 | 63671289 | 63671312 | 11 | - | 26472758 | Raji | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | -0.023640115252320848 | [310] | [70] | 0 | hSpCas9 | negative selection | 394165 | 63659160 | 63659183 | 11 | - | 26472758 | Raji | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | 2.1073835353735992 | [2] | [2] | 9 | hSpCas9 | negative selection | 394166 | 63631362 | 63631385 | 11 | - | 26472758 | Raji | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | -0.305812617081077 | [260] | [48] | -3 | hSpCas9 | negative selection | 394167 | 63659241 | 63659264 | 11 | - | 26472758 | Raji | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | 0.43916553100309125 | [320] | [100] | 4 | hSpCas9 | negative selection | 394168 | 63671304 | 63671327 | 11 | + | 26472758 | K562 | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | -0.6464336578503003 | [368] | [198] | -4 | hSpCas9 | negative selection | 585279 | 63659201 | 63659224 | 11 | + | 26472758 | K562 | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | 0.27160355699267713 | [367] | [374] | 2 | hSpCas9 | negative selection | 585280 | 63631312 | 63631335 | 11 | - | 26472758 | K562 | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | -3.3994374621082777 | [24] | [1] | -8 | hSpCas9 | negative selection | 585281 | 63631229 | 63631252 | 11 | + | 26472758 | K562 | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | -0.5365061553809503 | [310] | [180] | -3 | hSpCas9 | negative selection | 585282 | 63671289 | 63671312 | 11 | - | 26472758 | K562 | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | -0.44891993409950126 | [455] | [281] | -3 | hSpCas9 | negative selection | 585283 | 63659160 | 63659183 | 11 | - | 26472758 | K562 | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | 0.1448830541155326 | [59] | [55] | 1 | hSpCas9 | negative selection | 585284 | 63631362 | 63631385 | 11 | - | 26472758 | K562 | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | -0.13630440708706212 | [456] | [350] | -1 | hSpCas9 | negative selection | 585285 | 63659241 | 63659264 | 11 | - | 26472758 | K562 | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | -0.6584250348793698 | [444] | [237] | -4 | hSpCas9 | negative selection | 585286 | 63659074 | 63659097 | 11 | + | 26627737 | DLD1 | viability | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -0.08438738107301536 | [96] | [0,56,28] | -1 | hSpCas9 | negative selection | 779776 | 63671340 | 63671363 | 11 | - | 26627737 | DLD1 | viability | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | 0.09614969535515161 | [242] | [52,151,46] | 1 | hSpCas9 | negative selection | 779777 | 63671660 | 63671683 | 11 | - | 26627737 | DLD1 | viability | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 1.1187093726926431 | [256] | [123,164,225] | 8 | hSpCas9 | negative selection | 779778 | 63659074 | 63659097 | 11 | + | 26627737 | GBM cells | viability after 5 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -0.33374688190458945 | [46] | [35,3] | -5 | hSpCas9 | negative selection | 862091 | 63671340 | 63671363 | 11 | - | 26627737 | GBM cells | viability after 5 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | -0.11165536682450172 | [136] | [63,71] | -2 | hSpCas9 | negative selection | 862092 | 63671660 | 63671683 | 11 | - | 26627737 | GBM cells | viability after 5 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.3825156606476009 | [225] | [152,162] | 6 | hSpCas9 | negative selection | 862093 | 63659074 | 63659097 | 11 | + | 26627737 | GBM cells | viability after 13 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -2.1637588132051193 | [46] | [8,2] | -9 | hSpCas9 | negative selection | 944406 | 63671340 | 63671363 | 11 | - | 26627737 | GBM cells | viability after 13 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | 0.5862072238960083 | [136] | [131,94] | 7 | hSpCas9 | negative selection | 944407 | 63671660 | 63671683 | 11 | - | 26627737 | GBM cells | viability after 13 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.6477703954746153 | [225] | [222,166] | 7 | hSpCas9 | negative selection | 944408 | 63659074 | 63659097 | 11 | + | 26627737 | GBM cells | viability after 21 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -1.0382143274152598 | [46] | [13,10] | -7 | hSpCas9 | negative selection | 1026721 | 63671340 | 63671363 | 11 | - | 26627737 | GBM cells | viability after 21 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | 0.3480014602893935 | [136] | [100,88] | 3 | hSpCas9 | negative selection | 1026722 | 63671660 | 63671683 | 11 | - | 26627737 | GBM cells | viability after 21 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.6605454635472136 | [225] | [203,184] | 6 | hSpCas9 | negative selection | 1026723 | 63659074 | 63659097 | 11 | + | 26627737 | RPE1 | viability after 9 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 6.754518101306019 | [0] | [28,39] | 9 | hSpCas9 | negative selection | 1109036 | 63671340 | 63671363 | 11 | - | 26627737 | RPE1 | viability after 9 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | 0.41191229713318317 | [430] | [96,285] | 3 | hSpCas9 | negative selection | 1109037 | 63671660 | 63671683 | 11 | - | 26627737 | RPE1 | viability after 9 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.305721496659615 | [823] | [217,448] | 2 | hSpCas9 | negative selection | 1109038 | 63659074 | 63659097 | 11 | + | 26627737 | RPE1 | viability after 12 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 6.026571658418954 | [0] | [0,34] | 9 | hSpCas9 | negative selection | 1191351 | 63671340 | 63671363 | 11 | - | 26627737 | RPE1 | viability after 12 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | 0.04215354090246848 | [430] | [160,74] | 0 | hSpCas9 | negative selection | 1191352 | 63671660 | 63671683 | 11 | - | 26627737 | RPE1 | viability after 12 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.6558671143794834 | [823] | [188,517] | 4 | hSpCas9 | negative selection | 1191353 | 63659074 | 63659097 | 11 | + | 26627737 | RPE1 | viability after 15 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 6.272698840796118 | [0] | [0,41] | 9 | hSpCas9 | negative selection | 1273666 | 63671340 | 63671363 | 11 | - | 26627737 | RPE1 | viability after 15 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | -0.5259445003248125 | [430] | [102,66] | -3 | hSpCas9 | negative selection | 1273667 | 63671660 | 63671683 | 11 | - | 26627737 | RPE1 | viability after 15 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.27112590113432133 | [823] | [180,377] | 1 | hSpCas9 | negative selection | 1273668 | 63659074 | 63659097 | 11 | + | 26627737 | RPE1 | viability after 18 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 5.238018838821341 | [0] | [0,19] | 9 | hSpCas9 | negative selection | 1355981 | 63671340 | 63671363 | 11 | - | 26627737 | RPE1 | viability after 18 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | -0.1401610500203888 | [430] | [135,72] | -1 | hSpCas9 | negative selection | 1355982 | 63671660 | 63671683 | 11 | - | 26627737 | RPE1 | viability after 18 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.07901533020245141 | [823] | [85,393] | 0 | hSpCas9 | negative selection | 1355983 | 63659074 | 63659097 | 11 | + | 26627737 | HeLa | viability after 8 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -0.46878875695926814 | [67] | [16,36,9] | -4 | hSpCas9 | negative selection | 1438296 | 63671340 | 63671363 | 11 | - | 26627737 | HeLa | viability after 8 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | -1.166750309843119 | [334] | [70,87,38] | -8 | hSpCas9 | negative selection | 1438297 | 63671660 | 63671683 | 11 | - | 26627737 | HeLa | viability after 8 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | -0.31572103019024794 | [340] | [121,127,108] | -3 | hSpCas9 | negative selection | 1438298 | 63659074 | 63659097 | 11 | + | 26627737 | HeLa | viability after 12 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -0.11303251044691587 | [67] | [0,46,26] | -1 | hSpCas9 | negative selection | 1520611 | 63671340 | 63671363 | 11 | - | 26627737 | HeLa | viability after 12 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | -0.4508539551263143 | [334] | [171,24,116] | -4 | hSpCas9 | negative selection | 1520612 | 63671660 | 63671683 | 11 | - | 26627737 | HeLa | viability after 12 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.19701079835396704 | [340] | [84,221,168] | 1 | hSpCas9 | negative selection | 1520613 | 63659074 | 63659097 | 11 | + | 26627737 | HeLa | viability after 15 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -0.44858086322187196 | [67] | [0,28,31] | -4 | hSpCas9 | negative selection | 1602926 | 63671340 | 63671363 | 11 | - | 26627737 | HeLa | viability after 15 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | -1.5374667006683673 | [334] | [29,41,70] | -8 | hSpCas9 | negative selection | 1602927 | 63671660 | 63671683 | 11 | - | 26627737 | HeLa | viability after 15 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | -1.5249522752816578 | [340] | [24,71,47] | -8 | hSpCas9 | negative selection | 1602928 | 63659074 | 63659097 | 11 | + | 26627737 | HeLa | viability after 18 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -0.43696987590053604 | [67] | [0,23,31] | -4 | hSpCas9 | negative selection | 1685241 | 63671340 | 63671363 | 11 | - | 26627737 | HeLa | viability after 18 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | -1.6211611378675346 | [334] | [13,35,70] | -8 | hSpCas9 | negative selection | 1685242 | 63671660 | 63671683 | 11 | - | 26627737 | HeLa | viability after 18 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | -1.5260052556899122 | [340] | [17,57,47] | -8 | hSpCas9 | negative selection | 1685243 | 63659074 | 63659097 | 11 | + | 26627737 | HCT116 | viability after 6 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 1.5428149921801166 | [33] | [41,0] | 7 | hSpCas9 | negative selection | 1767556 | 63671340 | 63671363 | 11 | - | 26627737 | HCT116 | viability after 6 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | -1.2931032141086798 | [415] | [36,20] | -6 | hSpCas9 | negative selection | 1767557 | 63671660 | 63671683 | 11 | - | 26627737 | HCT116 | viability after 6 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | -0.5161114552928183 | [343] | [80,13] | -3 | hSpCas9 | negative selection | 1767558 | 63659074 | 63659097 | 11 | + | 26627737 | HCT116 | viability after 8 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -0.12618216484499944 | [60] | [55,18,17] | -1 | hSpCas9 | negative selection | 1849871 | 63671340 | 63671363 | 11 | - | 26627737 | HCT116 | viability after 8 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | 0.6358956646724336 | [121] | [94,95,121] | 6 | hSpCas9 | negative selection | 1849872 | 63671660 | 63671683 | 11 | - | 26627737 | HCT116 | viability after 8 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.6424988793624311 | [202] | [171,193,157] | 6 | hSpCas9 | negative selection | 1849873 | 63659074 | 63659097 | 11 | + | 26627737 | HCT116 | viability after 9 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -1.4890488624239255 | [33] | [0,4] | -8 | hSpCas9 | negative selection | 1932186 | 63671340 | 63671363 | 11 | - | 26627737 | HCT116 | viability after 9 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | 0.37492631757798334 | [415] | [52,215] | 3 | hSpCas9 | negative selection | 1932187 | 63671660 | 63671683 | 11 | - | 26627737 | HCT116 | viability after 9 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 1.3510325011279631 | [343] | [402,100] | 8 | hSpCas9 | negative selection | 1932188 | 63659074 | 63659097 | 11 | + | 26627737 | HCT116 | viability after 12 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -4.277635889327241 | [60] | [0,0,2] | -9 | hSpCas9 | negative selection | 2014501 | 63671340 | 63671363 | 11 | - | 26627737 | HCT116 | viability after 12 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | 0.7858556019657771 | [121] | [22,138,177] | 7 | hSpCas9 | negative selection | 2014502 | 63671660 | 63671683 | 11 | - | 26627737 | HCT116 | viability after 12 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.5132656175018689 | [202] | [116,197,145] | 5 | hSpCas9 | negative selection | 2014503 | 63659074 | 63659097 | 11 | + | 26627737 | HCT116 | viability after 15 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -2.3074233127262653 | [60] | [20,0,0] | -9 | hSpCas9 | negative selection | 2096816 | 63671340 | 63671363 | 11 | - | 26627737 | HCT116 | viability after 15 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | 0.6163633778401484 | [121] | [50,126,136] | 5 | hSpCas9 | negative selection | 2096817 | 63671660 | 63671683 | 11 | - | 26627737 | HCT116 | viability after 15 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.7106219581709287 | [202] | [170,128,268] | 6 | hSpCas9 | negative selection | 2096818 | 63659074 | 63659097 | 11 | + | 26627737 | HCT116 | viability after 18 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -1.4840761482913658 | [60] | [25,0,4] | -8 | hSpCas9 | negative selection | 2179131 | 63671340 | 63671363 | 11 | - | 26627737 | HCT116 | viability after 18 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | 0.4004349465856021 | [121] | [82,88,59] | 3 | hSpCas9 | negative selection | 2179132 | 63671660 | 63671683 | 11 | - | 26627737 | HCT116 | viability after 18 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.19969955238533188 | [202] | [85,81,174] | 1 | hSpCas9 | negative selection | 2179133 | 63671831 | 63671854 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CGGCGCCTAACGTGCAGACCAGG | ATL3 | ENSG00000184743 | 2.005214436356146 | [35,21] | [3,48] | 7 | dCas9-VP64 | positive selection | 2445901 | 63671899 | 63671922 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CTTTGGTGTTTAACTAGGCCTGG | ATL3 | ENSG00000184743 | -0.9775350543772088 | [64,111] | [2,15] | -6 | dCas9-VP64 | positive selection | 2445902 | 63671873 | 63671896 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TCTCTCACACTGGTGGTTCCAGG | ATL3 | ENSG00000184743 | -1.953351075520262 | [469,254] | [21,17] | -9 | dCas9-VP64 | positive selection | 2445903 | 63632018 | 63632041 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | ACAGGTGGGCCTTTCTCACCTGG | ATL3 | ENSG00000184743 | 4.40327251672642 | [40,26] | [304,4] | 9 | dCas9-VP64 | positive selection | 2450982 | 63671831 | 63671854 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CGGCGCCTAACGTGCAGACCAGG | ATL3 | ENSG00000184743 | 6.063044858868556 | [119,52] | [9,3700] | 9 | dCas9-VP64 | positive selection | 2541156 | 63671899 | 63671922 | 11 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CTTTGGTGTTTAACTAGGCCTGG | ATL3 | ENSG00000184743 | 0.05707552866342014 | [228,165] | [121,15] | 0 | dCas9-VP64 | positive selection | 2541157 | 63671873 | 63671896 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TCTCTCACACTGGTGGTTCCAGG | ATL3 | ENSG00000184743 | -0.7837057934732592 | [262,289] | [66,37] | -7 | dCas9-VP64 | positive selection | 2541158 | 63632018 | 63632041 | 11 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | ACAGGTGGGCCTTTCTCACCTGG | ATL3 | ENSG00000184743 | -0.9693414221315924 | [82,87] | [9,16] | -8 | dCas9-VP64 | positive selection | 2546237 | 63671314 | 63671337 | 11 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CATGTTGTCCCCTCAGCGAGTGG | ATL3 | ENSG00000184743 | 2.56608429728259 | [] | [] | 4 | hSpCas9 | negative selection | 3481891 | 63671314 | 63671337 | 11 | - | 26780180 | A375 | viability (Avana lentiGuide) | CATGTTGTCCCCTCAGCGAGTGG | ATL3 | ENSG00000184743 | 1.40139711928189 | [] | [] | 1 | hSpCas9 | negative selection | 3590550 | 63671314 | 63671337 | 11 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CATGTTGTCCCCTCAGCGAGTGG | ATL3 | ENSG00000184743 | 0.3186235792265001 | [4] | [5,5] | 8 | hSpCas9 | positive selection | 3699209 | 63671314 | 63671337 | 11 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CATGTTGTCCCCTCAGCGAGTGG | ATL3 | ENSG00000184743 | 0.09797096337368787 | [5] | [3,5] | 2 | hSpCas9 | positive selection | 3807816 | 63659075 | 63659097 | 11 | + | 27760321 | OCIAML3 | viability | AAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 0.5106132382756752 | [425,364] | [424,457] | 6 | hSpCas9 | negative selection | 4380340 | 63659131 | 63659153 | 11 | + | 27760321 | OCIAML3 | viability | TCGGATGTGGTCCTGCAAGAGG | ATL3 | ENSG00000184743 | 0.7584892113684805 | [327,329] | [382,506] | 8 | hSpCas9 | negative selection | 4380341 | 63659075 | 63659097 | 11 | + | 27760321 | OCIAML2 | viability | AAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -0.02054225176896049 | [425,364] | [288,347] | 0 | hSpCas9 | negative selection | 4463803 | 63659131 | 63659153 | 11 | + | 27760321 | OCIAML2 | viability | TCGGATGTGGTCCTGCAAGAGG | ATL3 | ENSG00000184743 | -0.17947372639561177 | [327,329] | [174,315] | -2 | hSpCas9 | negative selection | 4463804 | 63659075 | 63659097 | 11 | + | 27760321 | MV411 | viability | AAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 0.40215714672996317 | [425,364] | [396,263] | 3 | hSpCas9 | negative selection | 4547266 | 63659131 | 63659153 | 11 | + | 27760321 | MV411 | viability | TCGGATGTGGTCCTGCAAGAGG | ATL3 | ENSG00000184743 | -0.29400162894124815 | [327,329] | [64,346] | -2 | hSpCas9 | negative selection | 4547267 | 63659075 | 63659097 | 11 | + | 27760321 | HL60 | viability | AAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 0.15380651818629135 | [425,364] | [335,381] | 2 | hSpCas9 | negative selection | 4630729 | 63659131 | 63659153 | 11 | + | 27760321 | HL60 | viability | TCGGATGTGGTCCTGCAAGAGG | ATL3 | ENSG00000184743 | -0.010892907262564921 | [327,329] | [173,366] | 0 | hSpCas9 | negative selection | 4630730 | 63659075 | 63659097 | 11 | + | 27760321 | HT1080 | viability | AAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -2.852191033433651 | [364,284] | [26,7] | -7 | hSpCas9 | negative selection | 4714192 | 63659131 | 63659153 | 11 | + | 27760321 | HT1080 | viability | TCGGATGTGGTCCTGCAAGAGG | ATL3 | ENSG00000184743 | 0.041817492731435174 | [329,257] | [58,187] | 0 | hSpCas9 | negative selection | 4714193 | 63659075 | 63659097 | 11 | + | 27760321 | HT29 | viability after 7 days | AAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -0.044454382638039386 | [364,284] | [588,399,256] | 0 | hSpCas9 | negative selection | 4797655 | 63659131 | 63659153 | 11 | + | 27760321 | HT29 | viability after 7 days | TCGGATGTGGTCCTGCAAGAGG | ATL3 | ENSG00000184743 | 0.4398871799253755 | [329,257] | [805,403,373] | 6 | hSpCas9 | negative selection | 4797656 | 63659075 | 63659097 | 11 | + | 27760321 | HT29 | viability after 25 days | AAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 0.4520052374714462 | [364,284] | [444,612,464] | 5 | hSpCas9 | negative selection | 4881118 | 63659131 | 63659153 | 11 | + | 27760321 | HT29 | viability after 25 days | TCGGATGTGGTCCTGCAAGAGG | ATL3 | ENSG00000184743 | -0.15993370550828795 | [329,257] | [226,313,372] | -2 | hSpCas9 | negative selection | 4881119 | 63659075 | 63659097 | 11 | + | 27760321 | HT29 | viability after 22 days | AAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 0.12937981468165805 | [364,284] | [353,412,467] | 1 | hSpCas9 | negative selection | 4964581 | 63659131 | 63659153 | 11 | + | 27760321 | HT29 | viability after 22 days | TCGGATGTGGTCCTGCAAGAGG | ATL3 | ENSG00000184743 | 0.15336227176431766 | [329,257] | [354,372,406] | 1 | hSpCas9 | negative selection | 4964582 | 63659075 | 63659097 | 11 | + | 27760321 | HT29 | viability after 19 days | AAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 0.05850320647660198 | [364,284] | [564,451,170] | 0 | hSpCas9 | negative selection | 5048044 | 63659131 | 63659153 | 11 | + | 27760321 | HT29 | viability after 19 days | TCGGATGTGGTCCTGCAAGAGG | ATL3 | ENSG00000184743 | 0.17321383325685824 | [329,257] | [559,452,151] | 1 | hSpCas9 | negative selection | 5048045 | 63659075 | 63659097 | 11 | + | 27760321 | HT29 | viability after 16 days | AAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 0.1602662526912771 | [364,284] | [474,576,168] | 1 | hSpCas9 | negative selection | 5131507 | 63659131 | 63659153 | 11 | + | 27760321 | HT29 | viability after 16 days | TCGGATGTGGTCCTGCAAGAGG | ATL3 | ENSG00000184743 | 0.5220514606899072 | [329,257] | [434,493,483] | 6 | hSpCas9 | negative selection | 5131508 | 63659075 | 63659097 | 11 | + | 27760321 | HT29 | viability after 13 days | AAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 0.2211694549779764 | [364,284] | [453,536,333] | 2 | hSpCas9 | negative selection | 5214970 | 63659131 | 63659153 | 11 | + | 27760321 | HT29 | viability after 13 days | TCGGATGTGGTCCTGCAAGAGG | ATL3 | ENSG00000184743 | 0.28016008651870034 | [329,257] | [443,494,309] | 3 | hSpCas9 | negative selection | 5214971 | 63659075 | 63659097 | 11 | + | 27760321 | HT29 | viability after 10 days | AAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -0.12621899417867544 | [364,284] | [289,541,289] | -2 | hSpCas9 | negative selection | 5298433 | 63659131 | 63659153 | 11 | + | 27760321 | HT29 | viability after 10 days | TCGGATGTGGTCCTGCAAGAGG | ATL3 | ENSG00000184743 | 0.30349461278172896 | [329,257] | [565,399,392] | 4 | hSpCas9 | negative selection | 5298434 | 63659075 | 63659097 | 11 | + | 27760321 | MOLM13 | viability | AAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -1.163132527506195 | [425,364] | [40,148] | -6 | hSpCas9 | negative selection | 5381896 | 63659131 | 63659153 | 11 | + | 27760321 | MOLM13 | viability | TCGGATGTGGTCCTGCAAGAGG | ATL3 | ENSG00000184743 | -3.2384701981854143 | [327,329] | [29,10] | -9 | hSpCas9 | negative selection | 5381897 | 63671371 | 63671394 | 11 | + | 27661255 | K562 | viability | GCAGAGGAGAGGGACGGGTGCGG | ATL3 | ENSG00000184743 | 0.1401822240618731 | [542,696] | [612,483] | 5 | dCas9-KRAB | negative selection | 5464060 | 63671387 | 63671410 | 11 | + | 27661255 | K562 | viability | GGTGCGGGCGGGAACGAACCGGG | ATL3 | ENSG00000184743 | -0.0673397983366371 | [734,762] | [622,525] | -3 | dCas9-KRAB | negative selection | 5464061 | 63671509 | 63671532 | 11 | + | 27661255 | K562 | viability | GTGGCCCAACGGACAGCCCGAGG | ATL3 | ENSG00000184743 | 0.016178659622351977 | [795,720] | [683,553] | 0 | dCas9-KRAB | negative selection | 5464062 | 63659074 | 63659097 | 11 | + | 27869803 | HPAFII | viability after 27 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -1.5974395058891706 | [44] | [15,0,NaN] | -7 | hSpCas9 | negative selection | 9542776 | 63671340 | 63671363 | 11 | - | 27869803 | HPAFII | viability after 27 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | -0.5037106838970925 | [164] | [28,87,NaN] | -4 | hSpCas9 | negative selection | 9542777 | 63671660 | 63671683 | 11 | - | 27869803 | HPAFII | viability after 27 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 1.39915389266758 | [264] | [559,206,NaN] | 9 | hSpCas9 | negative selection | 9542778 | 63659074 | 63659097 | 11 | + | 27869803 | HPAFII | viability after 15 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 0.30484744541234354 | [44] | [150,2,NaN] | 3 | hSpCas9 | negative selection | 9625225 | 63671340 | 63671363 | 11 | - | 27869803 | HPAFII | viability after 15 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | -0.47466416466809747 | [164] | [89,150,NaN] | -5 | hSpCas9 | negative selection | 9625226 | 63671660 | 63671683 | 11 | - | 27869803 | HPAFII | viability after 15 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.6543454692463535 | [264] | [824,213,NaN] | 7 | hSpCas9 | negative selection | 9625227 | 63659074 | 63659097 | 11 | + | 27869803 | ASPC1 | viability after 36 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -1.2674678796699799 | [78] | [0,5,22] | -8 | hSpCas9 | negative selection | 9707674 | 63671340 | 63671363 | 11 | - | 27869803 | ASPC1 | viability after 36 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | 0.30455696844164193 | [305] | [265,129,37] | 3 | hSpCas9 | negative selection | 9707675 | 63671660 | 63671683 | 11 | - | 27869803 | ASPC1 | viability after 36 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.7041168894151273 | [562] | [202,197,495] | 7 | hSpCas9 | negative selection | 9707676 | 63659074 | 63659097 | 11 | + | 27869803 | PATU8988S | viability after 35 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 0.9148061666569554 | [76] | [43,72,NaN] | 8 | hSpCas9 | negative selection | 9790123 | 63671340 | 63671363 | 11 | - | 27869803 | PATU8988S | viability after 35 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | -0.8107825615754889 | [371] | [45,124,NaN] | -7 | hSpCas9 | negative selection | 9790124 | 63671660 | 63671683 | 11 | - | 27869803 | PATU8988S | viability after 35 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.4805338017739509 | [587] | [295,364,NaN] | 5 | hSpCas9 | negative selection | 9790125 | 63659074 | 63659097 | 11 | + | 27869803 | PATU8988S | viability after 31 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | 0.8483379551498256 | [76] | [49,61,NaN] | 8 | hSpCas9 | negative selection | 9872572 | 63671340 | 63671363 | 11 | - | 27869803 | PATU8988S | viability after 31 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | -0.2150192696238915 | [371] | [96,166,NaN] | -2 | hSpCas9 | negative selection | 9872573 | 63671660 | 63671683 | 11 | - | 27869803 | PATU8988S | viability after 31 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 0.3393284535220309 | [587] | [260,341,NaN] | 4 | hSpCas9 | negative selection | 9872574 | 63659074 | 63659097 | 11 | + | 27869803 | HPAFII | viability after 35 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -4.5097645433330005 | [44] | [0,0,NaN] | -9 | hSpCas9 | negative selection | 9955021 | 63671340 | 63671363 | 11 | - | 27869803 | HPAFII | viability after 35 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | -0.8319518593226475 | [164] | [13,83,NaN] | -5 | hSpCas9 | negative selection | 9955022 | 63671660 | 63671683 | 11 | - | 27869803 | HPAFII | viability after 35 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 1.3499757989048167 | [264] | [523,136,NaN] | 8 | hSpCas9 | negative selection | 9955023 | 63659074 | 63659097 | 11 | + | 27869803 | HPAFII | viability after 31 days | GAAGGACTTGCCCTTTCGGAAGG | ATL3 | ENSG00000184743 | -1.4412511804337478 | [44] | [15,1,NaN] | -7 | hSpCas9 | negative selection | 10037470 | 63671340 | 63671363 | 11 | - | 27869803 | HPAFII | viability after 31 days | TGCTTCTGCTTTGAAGGCGGAGG | ATL3 | ENSG00000184743 | -1.248606102491352 | [164] | [15,63,NaN] | -6 | hSpCas9 | negative selection | 10037471 | 63671660 | 63671683 | 11 | - | 27869803 | HPAFII | viability after 31 days | GGACTACAATTCCCAAAGGACGG | ATL3 | ENSG00000184743 | 1.4529392423238534 | [264] | [577,220,NaN] | 9 | hSpCas9 | negative selection | 10037472 | 63671304 | 63671327 | 11 | + | 28162770 | P31FUJ | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | 0.10280082737006024 | [125] | [158] | 1 | hSpCas9 | negative selection | 10115379 | 63659201 | 63659224 | 11 | + | 28162770 | P31FUJ | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | 0.45880285635195195 | [251] | [406] | 5 | hSpCas9 | negative selection | 10115380 | 63631312 | 63631335 | 11 | - | 28162770 | P31FUJ | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | -3.2328022044143783 | [7] | [0] | -9 | hSpCas9 | negative selection | 10115381 | 63631229 | 63631252 | 11 | + | 28162770 | P31FUJ | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | 0.4661164856038634 | [145] | [236] | 5 | hSpCas9 | negative selection | 10115382 | 63671289 | 63671312 | 11 | - | 28162770 | P31FUJ | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | 0.41136929407996836 | [182] | [285] | 4 | hSpCas9 | negative selection | 10115383 | 63659160 | 63659183 | 11 | - | 28162770 | P31FUJ | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | -0.09529868066444358 | [39] | [43] | -1 | hSpCas9 | negative selection | 10115384 | 63631362 | 63631385 | 11 | - | 28162770 | P31FUJ | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | 0.06713688669992574 | [237] | [292] | 0 | hSpCas9 | negative selection | 10115385 | 63659241 | 63659264 | 11 | - | 28162770 | P31FUJ | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | 0.4692175106439035 | [350] | [570] | 5 | hSpCas9 | negative selection | 10115386 | 63671304 | 63671327 | 11 | + | 28162770 | TF1 | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | NaN | [NaN] | [112] | 1 | hSpCas9 | negative selection | 10284745 | 63659201 | 63659224 | 11 | + | 28162770 | TF1 | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | NaN | [NaN] | [308] | 1 | hSpCas9 | negative selection | 10284746 | 63631312 | 63631335 | 11 | - | 28162770 | TF1 | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | NaN | [NaN] | [0] | 1 | hSpCas9 | negative selection | 10284747 | 63631229 | 63631252 | 11 | + | 28162770 | TF1 | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | NaN | [NaN] | [72] | 1 | hSpCas9 | negative selection | 10284748 | 63671289 | 63671312 | 11 | - | 28162770 | TF1 | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | NaN | [NaN] | [220] | 1 | hSpCas9 | negative selection | 10284749 | 63659160 | 63659183 | 11 | - | 28162770 | TF1 | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | NaN | [NaN] | [22] | 1 | hSpCas9 | negative selection | 10284750 | 63631362 | 63631385 | 11 | - | 28162770 | TF1 | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | NaN | [NaN] | [205] | 1 | hSpCas9 | negative selection | 10284751 | 63659241 | 63659264 | 11 | - | 28162770 | TF1 | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | NaN | [NaN] | [284] | 1 | hSpCas9 | negative selection | 10284752 | 63671304 | 63671327 | 11 | + | 28162770 | SKM1 | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | 1.3051102198813336 | [37] | [165] | 9 | hSpCas9 | negative selection | 10454111 | 63659201 | 63659224 | 11 | + | 28162770 | SKM1 | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | -0.2480103151218524 | [87] | [130] | -2 | hSpCas9 | negative selection | 10454112 | 63631312 | 63631335 | 11 | - | 28162770 | SKM1 | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | -2.8220016980220053 | [3] | [0] | -9 | hSpCas9 | negative selection | 10454113 | 63631229 | 63631252 | 11 | + | 28162770 | SKM1 | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | -0.5489832036155895 | [47] | [57] | -4 | hSpCas9 | negative selection | 10454114 | 63671289 | 63671312 | 11 | - | 28162770 | SKM1 | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | 0.6202206305830686 | [45] | [124] | 6 | hSpCas9 | negative selection | 10454115 | 63659160 | 63659183 | 11 | - | 28162770 | SKM1 | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | 2.1165977573138512 | [5] | [45] | 9 | hSpCas9 | negative selection | 10454116 | 63631362 | 63631385 | 11 | - | 28162770 | SKM1 | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | 1.3366960479970527 | [42] | [191] | 9 | hSpCas9 | negative selection | 10454117 | 63659241 | 63659264 | 11 | - | 28162770 | SKM1 | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | 0.21626831890571174 | [92] | [190] | 2 | hSpCas9 | negative selection | 10454118 | 63671304 | 63671327 | 11 | + | 28162770 | SKM1 | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | 1.3051102198813336 | [37] | [165] | 9 | hSpCas9 | negative selection | 10623477 | 63659201 | 63659224 | 11 | + | 28162770 | SKM1 | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | -0.2480103151218524 | [87] | [130] | -2 | hSpCas9 | negative selection | 10623478 | 63631312 | 63631335 | 11 | - | 28162770 | SKM1 | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | -2.8220016980220053 | [3] | [0] | -9 | hSpCas9 | negative selection | 10623479 | 63631229 | 63631252 | 11 | + | 28162770 | SKM1 | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | -0.5489832036155895 | [47] | [57] | -4 | hSpCas9 | negative selection | 10623480 | 63671289 | 63671312 | 11 | - | 28162770 | SKM1 | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | 0.6202206305830686 | [45] | [124] | 6 | hSpCas9 | negative selection | 10623481 | 63659160 | 63659183 | 11 | - | 28162770 | SKM1 | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | 2.1165977573138512 | [5] | [45] | 9 | hSpCas9 | negative selection | 10623482 | 63631362 | 63631385 | 11 | - | 28162770 | SKM1 | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | 1.3366960479970527 | [42] | [191] | 9 | hSpCas9 | negative selection | 10623483 | 63659241 | 63659264 | 11 | - | 28162770 | SKM1 | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | 0.21626831890571174 | [92] | [190] | 2 | hSpCas9 | negative selection | 10623484 | 63671304 | 63671327 | 11 | + | 28162770 | PL21 | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | -0.4200123146941359 | [165] | [53] | -3 | hSpCas9 | negative selection | 10792843 | 63659201 | 63659224 | 11 | + | 28162770 | PL21 | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | -1.0502352193730082 | [294] | [61] | -6 | hSpCas9 | negative selection | 10792844 | 63631312 | 63631335 | 11 | - | 28162770 | PL21 | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | -1.1217884803980427 | [4] | [0] | -6 | hSpCas9 | negative selection | 10792845 | 63631229 | 63631252 | 11 | + | 28162770 | PL21 | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | -1.0093137511396297 | [147] | [31] | -6 | hSpCas9 | negative selection | 10792846 | 63671289 | 63671312 | 11 | - | 28162770 | PL21 | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | 0.7386916502535182 | [178] | [129] | 6 | hSpCas9 | negative selection | 10792847 | 63659160 | 63659183 | 11 | - | 28162770 | PL21 | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | 0.06263609073938525 | [21] | [9] | 0 | hSpCas9 | negative selection | 10792848 | 63631362 | 63631385 | 11 | - | 28162770 | PL21 | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | -0.83349116339196 | [216] | [52] | -5 | hSpCas9 | negative selection | 10792849 | 63659241 | 63659264 | 11 | - | 28162770 | PL21 | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | 0.004743925530889537 | [299] | [130] | 0 | hSpCas9 | negative selection | 10792850 | 63671304 | 63671327 | 11 | + | 28162770 | P31FUJ | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | 0.10280082737006024 | [125] | [158] | 1 | hSpCas9 | negative selection | 10962209 | 63659201 | 63659224 | 11 | + | 28162770 | P31FUJ | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | 0.45880285635195195 | [251] | [406] | 5 | hSpCas9 | negative selection | 10962210 | 63631312 | 63631335 | 11 | - | 28162770 | P31FUJ | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | -3.2328022044143783 | [7] | [0] | -9 | hSpCas9 | negative selection | 10962211 | 63631229 | 63631252 | 11 | + | 28162770 | P31FUJ | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | 0.4661164856038634 | [145] | [236] | 5 | hSpCas9 | negative selection | 10962212 | 63671289 | 63671312 | 11 | - | 28162770 | P31FUJ | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | 0.41136929407996836 | [182] | [285] | 4 | hSpCas9 | negative selection | 10962213 | 63659160 | 63659183 | 11 | - | 28162770 | P31FUJ | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | -0.09529868066444358 | [39] | [43] | -1 | hSpCas9 | negative selection | 10962214 | 63631362 | 63631385 | 11 | - | 28162770 | P31FUJ | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | 0.06713688669992574 | [237] | [292] | 0 | hSpCas9 | negative selection | 10962215 | 63659241 | 63659264 | 11 | - | 28162770 | P31FUJ | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | 0.4692175106439035 | [350] | [570] | 5 | hSpCas9 | negative selection | 10962216 | 63671304 | 63671327 | 11 | + | 28162770 | OCIAML5 | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | 0.34691446386239877 | [70] | [162] | 3 | hSpCas9 | negative selection | 11131575 | 63659201 | 63659224 | 11 | + | 28162770 | OCIAML5 | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | 0.21094322666180354 | [223] | [467] | 1 | hSpCas9 | negative selection | 11131576 | 63631312 | 63631335 | 11 | - | 28162770 | OCIAML5 | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | -5.244383993642757 | [20] | [0] | -9 | hSpCas9 | negative selection | 11131577 | 63631229 | 63631252 | 11 | + | 28162770 | OCIAML5 | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | -1.2799281105004245 | [112] | [83] | -6 | hSpCas9 | negative selection | 11131578 | 63671289 | 63671312 | 11 | - | 28162770 | OCIAML5 | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | 0.6643316433740878 | [78] | [225] | 6 | hSpCas9 | negative selection | 11131579 | 63659160 | 63659183 | 11 | - | 28162770 | OCIAML5 | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | -2.8520665708639967 | [3] | [0] | -8 | hSpCas9 | negative selection | 11131580 | 63631362 | 63631385 | 11 | - | 28162770 | OCIAML5 | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | 0.030576478497844284 | [127] | [235] | 0 | hSpCas9 | negative selection | 11131581 | 63659241 | 63659264 | 11 | - | 28162770 | OCIAML5 | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | 0.4162510557766048 | [158] | [382] | 3 | hSpCas9 | negative selection | 11131582 | 63671304 | 63671327 | 11 | + | 28162770 | EOL1 | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | 0.6232999295228471 | [328] | [266] | 5 | hSpCas9 | negative selection | 11300941 | 63659201 | 63659224 | 11 | + | 28162770 | EOL1 | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | -0.03093356165082084 | [350] | [180] | 0 | hSpCas9 | negative selection | 11300942 | 63631312 | 63631335 | 11 | - | 28162770 | EOL1 | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | -1.660414729150622 | [17] | [2] | -8 | hSpCas9 | negative selection | 11300943 | 63631229 | 63631252 | 11 | + | 28162770 | EOL1 | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | -0.3099174820664882 | [279] | [118] | -2 | hSpCas9 | negative selection | 11300944 | 63671289 | 63671312 | 11 | - | 28162770 | EOL1 | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | -0.12096688768183422 | [321] | [155] | -1 | hSpCas9 | negative selection | 11300945 | 63659160 | 63659183 | 11 | - | 28162770 | EOL1 | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | 1.4825432246914212 | [35] | [52] | 9 | hSpCas9 | negative selection | 11300946 | 63631362 | 63631385 | 11 | - | 28162770 | EOL1 | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | 0.01597079933412926 | [213] | [113] | 0 | hSpCas9 | negative selection | 11300947 | 63659241 | 63659264 | 11 | - | 28162770 | EOL1 | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | -0.7034834510425076 | [339] | [109] | -5 | hSpCas9 | negative selection | 11300948 | 63671304 | 63671327 | 11 | + | 28162770 | MOLM13 | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | -0.07839265101251747 | [183] | [125] | 0 | hSpCas9 | negative selection | 11470307 | 63659201 | 63659224 | 11 | + | 28162770 | MOLM13 | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | -1.1201723578354639 | [465] | [154] | -5 | hSpCas9 | negative selection | 11470308 | 63631312 | 63631335 | 11 | - | 28162770 | MOLM13 | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | -3.232550336596514 | [12] | [0] | -8 | hSpCas9 | negative selection | 11470309 | 63631229 | 63631252 | 11 | + | 28162770 | MOLM13 | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | 0.17570863005126852 | [179] | [146] | 1 | hSpCas9 | negative selection | 11470310 | 63671289 | 63671312 | 11 | - | 28162770 | MOLM13 | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | 0.9269247098234198 | [330] | [454] | 7 | hSpCas9 | negative selection | 11470311 | 63659160 | 63659183 | 11 | - | 28162770 | MOLM13 | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | -0.011278455153980627 | [45] | [32] | 0 | hSpCas9 | negative selection | 11470312 | 63631362 | 63631385 | 11 | - | 28162770 | MOLM13 | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | -0.39141175554567953 | [204] | [112] | -2 | hSpCas9 | negative selection | 11470313 | 63659241 | 63659264 | 11 | - | 28162770 | MOLM13 | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | -0.6800440475914243 | [471] | [212] | -4 | hSpCas9 | negative selection | 11470314 | 63671304 | 63671327 | 11 | + | 28162770 | HEL | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | -0.6235412333370911 | [177] | [73] | -4 | hSpCas9 | negative selection | 11639673 | 63659201 | 63659224 | 11 | + | 28162770 | HEL | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | 0.011845828055403351 | [366] | [236] | 0 | hSpCas9 | negative selection | 11639674 | 63631312 | 63631335 | 11 | - | 28162770 | HEL | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | 0.7422745055512707 | [13] | [14] | 6 | hSpCas9 | negative selection | 11639675 | 63631229 | 63631252 | 11 | + | 28162770 | HEL | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | -0.14153247694420584 | [185] | [107] | -1 | hSpCas9 | negative selection | 11639676 | 63671289 | 63671312 | 11 | - | 28162770 | HEL | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | 0.7039026946787525 | [253] | [264] | 6 | hSpCas9 | negative selection | 11639677 | 63659160 | 63659183 | 11 | - | 28162770 | HEL | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | -0.3572611679996429 | [31] | [15] | -2 | hSpCas9 | negative selection | 11639678 | 63631362 | 63631385 | 11 | - | 28162770 | HEL | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | -0.1057224010036788 | [167] | [99] | -1 | hSpCas9 | negative selection | 11639679 | 63659241 | 63659264 | 11 | - | 28162770 | HEL | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | -0.5698725685435057 | [342] | [147] | -4 | hSpCas9 | negative selection | 11639680 | 63671304 | 63671327 | 11 | + | 28162770 | MV411 | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | 0.31416366458358835 | [168] | [176] | 2 | hSpCas9 | negative selection | 11809039 | 63659201 | 63659224 | 11 | + | 28162770 | MV411 | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | -0.13513555324955695 | [248] | [190] | -1 | hSpCas9 | negative selection | 11809040 | 63631312 | 63631335 | 11 | - | 28162770 | MV411 | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | -3.840025290467564 | [16] | [0] | -9 | hSpCas9 | negative selection | 11809041 | 63631229 | 63631252 | 11 | + | 28162770 | MV411 | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | -1.3660941021351518 | [152] | [49] | -7 | hSpCas9 | negative selection | 11809042 | 63671289 | 63671312 | 11 | - | 28162770 | MV411 | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | 0.6349539872977144 | [171] | [224] | 6 | hSpCas9 | negative selection | 11809043 | 63659160 | 63659183 | 11 | - | 28162770 | MV411 | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | -4.453002167358317 | [25] | [0] | -9 | hSpCas9 | negative selection | 11809044 | 63631362 | 63631385 | 11 | - | 28162770 | MV411 | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | -0.1556273068299925 | [159] | [120] | -1 | hSpCas9 | negative selection | 11809045 | 63659241 | 63659264 | 11 | - | 28162770 | MV411 | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | -0.22554729770534795 | [253] | [182] | -2 | hSpCas9 | negative selection | 11809046 | 63671304 | 63671327 | 11 | + | 28162770 | MONOMAC1 | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | -0.5401814278566118 | [136] | [107] | -4 | hSpCas9 | negative selection | 11978405 | 63659201 | 63659224 | 11 | + | 28162770 | MONOMAC1 | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | 0.1655332323251546 | [202] | [260] | 1 | hSpCas9 | negative selection | 11978406 | 63631312 | 63631335 | 11 | - | 28162770 | MONOMAC1 | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | 0.7358489570819091 | [10] | [20] | 7 | hSpCas9 | negative selection | 11978407 | 63631229 | 63631252 | 11 | + | 28162770 | MONOMAC1 | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | 0.5134565357454614 | [87] | [143] | 5 | hSpCas9 | negative selection | 11978408 | 63671289 | 63671312 | 11 | - | 28162770 | MONOMAC1 | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | -0.10776950896246627 | [140] | [149] | -1 | hSpCas9 | negative selection | 11978409 | 63659160 | 63659183 | 11 | - | 28162770 | MONOMAC1 | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | 0.35045094824293965 | [12] | [18] | 3 | hSpCas9 | negative selection | 11978410 | 63631362 | 63631385 | 11 | - | 28162770 | MONOMAC1 | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | -0.9919224171549413 | [143] | [82] | -7 | hSpCas9 | negative selection | 11978411 | 63659241 | 63659264 | 11 | - | 28162770 | MONOMAC1 | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | 0.1991908024445317 | [192] | [253] | 2 | hSpCas9 | negative selection | 11978412 | 63671304 | 63671327 | 11 | + | 28162770 | OCIAML2 | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | 0.2901825108784126 | [26] | [182] | 2 | hSpCas9 | negative selection | 12147771 | 63659201 | 63659224 | 11 | + | 28162770 | OCIAML2 | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | 0.04218288972315942 | [40] | [233] | 0 | hSpCas9 | negative selection | 12147772 | 63631312 | 63631335 | 11 | - | 28162770 | OCIAML2 | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | -1.4706298252421615 | [1] | [3] | -7 | hSpCas9 | negative selection | 12147773 | 63631229 | 63631252 | 11 | + | 28162770 | OCIAML2 | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | -1.3007048237998489 | [27] | [62] | -7 | hSpCas9 | negative selection | 12147774 | 63671289 | 63671312 | 11 | - | 28162770 | OCIAML2 | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | -0.308742142865267 | [39] | [178] | -3 | hSpCas9 | negative selection | 12147775 | 63659160 | 63659183 | 11 | - | 28162770 | OCIAML2 | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | -0.5637392296336428 | [7] | [29] | -4 | hSpCas9 | negative selection | 12147776 | 63631362 | 63631385 | 11 | - | 28162770 | OCIAML2 | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | -0.7024455004652348 | [31] | [108] | -5 | hSpCas9 | negative selection | 12147777 | 63659241 | 63659264 | 11 | - | 28162770 | OCIAML2 | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | 0.4436403007319547 | [38] | [293] | 4 | hSpCas9 | negative selection | 12147778 | 63671304 | 63671327 | 11 | + | 28162770 | OCIAML3 | viability | GCAGCTGCTGCCACTCGCTGAGG | ATL3 | ENSG00000184743 | 0.46900215720163724 | [27] | [116] | 4 | hSpCas9 | negative selection | 12317137 | 63659201 | 63659224 | 11 | + | 28162770 | OCIAML3 | viability | TGAACCAAAACAACCTGCACTGG | ATL3 | ENSG00000184743 | 0.047262301298947096 | [66] | [208] | 0 | hSpCas9 | negative selection | 12317138 | 63631312 | 63631335 | 11 | - | 28162770 | OCIAML3 | viability | GGAGCTGGAGGAGGAAATCAAGG | ATL3 | ENSG00000184743 | -1.594007640324163 | [0] | [0] | -8 | hSpCas9 | negative selection | 12317139 | 63631229 | 63631252 | 11 | + | 28162770 | OCIAML3 | viability | GCCCGTGAACAGCACTGCAGGGG | ATL3 | ENSG00000184743 | -1.2595886012536042 | [45] | [57] | -7 | hSpCas9 | negative selection | 12317140 | 63671289 | 63671312 | 11 | - | 28162770 | OCIAML3 | viability | GCAGCTGCCTCAAGAGGAGCAGG | ATL3 | ENSG00000184743 | 0.43065441391010606 | [57] | [235] | 4 | hSpCas9 | negative selection | 12317141 | 63659160 | 63659183 | 11 | - | 28162770 | OCIAML3 | viability | TGAGCTAGATGAGAAAGCCTTGG | ATL3 | ENSG00000184743 | -1.17897014104532 | [2] | [3] | -7 | hSpCas9 | negative selection | 12317142 | 63631362 | 63631385 | 11 | - | 28162770 | OCIAML3 | viability | AAGAAGACCAAGAAGATGGGTGG | ATL3 | ENSG00000184743 | 0.5394753651500889 | [48] | [214] | 5 | hSpCas9 | negative selection | 12317143 | 63659241 | 63659264 | 11 | - | 28162770 | OCIAML3 | viability | CATGAACATAGATGATGCCATGG | ATL3 | ENSG00000184743 | 1.7185825899838632 | [61] | [615] | 9 | hSpCas9 | negative selection | 12317144 |