Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:834
• Symbol:CASP1
• Description:caspase 1

DataSource: http://genomecrispr.dkfz.de/#!/results/CASP1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
105034299	105034322	11	+	26472758	Jiyoye	viability	AACGGAGTCAATCAAAGCTCGGG	CASP1	ENSG00000137752	-0.7874720493476702	[102]	[44]	-5	hSpCas9	negative selection	23467
105034207	105034230	11	-	26472758	Jiyoye	viability	GGGACGCTGGGACTCTCAGCAGG	CASP1	ENSG00000137752	-0.28189552255602135	[78]	[48]	-2	hSpCas9	negative selection	23478
105034430	105034453	11	-	26472758	Jiyoye	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	1.75509868492618	[32]	[83]	8	hSpCas9	negative selection	23699
105031235	105031258	11	-	26472758	Jiyoye	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	-0.13067452337716345	[240]	[165]	-1	hSpCas9	negative selection	23700
105026291	105026314	11	+	26472758	Jiyoye	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	0.5988346753027138	[548]	[626]	4	hSpCas9	negative selection	23701
105026265	105026288	11	-	26472758	Jiyoye	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.658907138274166	[298]	[355]	5	hSpCas9	negative selection	23702
105029692	105029715	11	-	26472758	Jiyoye	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	-0.8104160535667533	[199]	[85]	-5	hSpCas9	negative selection	23703
105031164	105031187	11	-	26472758	Jiyoye	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.20587699180404972	[214]	[186]	1	hSpCas9	negative selection	23704
105029802	105029825	11	-	26472758	Jiyoye	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	5.799492804284633	[0]	[41]	9	hSpCas9	negative selection	23705
105029654	105029677	11	+	26472758	Jiyoye	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	-0.7500079510448567	[309]	[138]	-5	hSpCas9	negative selection	23706
105029667	105029690	11	-	26472758	Jiyoye	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	-0.10453813718464419	[143]	[100]	0	hSpCas9	negative selection	23707
105031256	105031279	11	+	26472758	Jiyoye	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	0.2885308850072544	[75]	[69]	2	hSpCas9	negative selection	23709
105034299	105034322	11	+	26472758	KBM7	viability	AACGGAGTCAATCAAAGCTCGGG	CASP1	ENSG00000137752	0.6160781605245731	[246,160]	[133,153]	6	hSpCas9	negative selection	214585
105034207	105034230	11	-	26472758	KBM7	viability	GGGACGCTGGGACTCTCAGCAGG	CASP1	ENSG00000137752	-0.5855882348787951	[330,295]	[85,108]	-5	hSpCas9	negative selection	214596
105034430	105034453	11	-	26472758	KBM7	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.6252929648036168	[396,299]	[327,180]	6	hSpCas9	negative selection	214817
105031235	105031258	11	-	26472758	KBM7	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	0.7775885312651858	[849,881]	[839,579]	8	hSpCas9	negative selection	214818
105026291	105026314	11	+	26472758	KBM7	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	0.6978972160798946	[2256,1427]	[1666,1122]	7	hSpCas9	negative selection	214819
105026265	105026288	11	-	26472758	KBM7	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.5202457516489047	[1635,1140]	[1002,852]	5	hSpCas9	negative selection	214820
105029692	105029715	11	-	26472758	KBM7	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	0.5717102161977137	[468,356]	[313,260]	6	hSpCas9	negative selection	214821
105031164	105031187	11	-	26472758	KBM7	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.10573782218033334	[799,600]	[388,316]	1	hSpCas9	negative selection	214822
105029802	105029825	11	-	26472758	KBM7	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	0.2724020277606821	[384,247]	[107,237]	3	hSpCas9	negative selection	214823
105029654	105029677	11	+	26472758	KBM7	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	0.0720032322731835	[841,695]	[420,339]	0	hSpCas9	negative selection	214824
105029667	105029690	11	-	26472758	KBM7	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	-0.041196414130850456	[756,626]	[272,351]	0	hSpCas9	negative selection	214825
105031256	105031279	11	+	26472758	KBM7	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	0.8995327647990601	[385,384]	[325,351]	8	hSpCas9	negative selection	214827
105034299	105034322	11	+	26472758	Raji	viability	AACGGAGTCAATCAAAGCTCGGG	CASP1	ENSG00000137752	-0.17272438381913569	[101]	[20]	-1	hSpCas9	negative selection	405703
105034207	105034230	11	-	26472758	Raji	viability	GGGACGCTGGGACTCTCAGCAGG	CASP1	ENSG00000137752	-1.3166427471324993	[160]	[14]	-7	hSpCas9	negative selection	405714
105034430	105034453	11	-	26472758	Raji	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.42201913769460586	[118]	[36]	4	hSpCas9	negative selection	405935
105031235	105031258	11	-	26472758	Raji	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	0.7979002068528824	[403]	[162]	7	hSpCas9	negative selection	405936
105026291	105026314	11	+	26472758	Raji	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	0.21429873929011123	[1143]	[307]	2	hSpCas9	negative selection	405937
105026265	105026288	11	-	26472758	Raji	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.594313953134229	[547]	[191]	5	hSpCas9	negative selection	405938
105029692	105029715	11	-	26472758	Raji	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	0.45159969746274636	[166]	[52]	4	hSpCas9	negative selection	405939
105031164	105031187	11	-	26472758	Raji	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.4184700706135348	[373]	[115]	4	hSpCas9	negative selection	405940
105029802	105029825	11	-	26472758	Raji	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	-0.4029896489268731	[244]	[42]	-3	hSpCas9	negative selection	405941
105029654	105029677	11	+	26472758	Raji	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	-1.324169050688261	[409]	[37]	-7	hSpCas9	negative selection	405942
105029667	105029690	11	-	26472758	Raji	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	0.7781996244834379	[298]	[118]	7	hSpCas9	negative selection	405943
105031256	105031279	11	+	26472758	Raji	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	-0.20797190559027667	[218]	[43]	-2	hSpCas9	negative selection	405945
105034299	105034322	11	+	26472758	K562	viability	AACGGAGTCAATCAAAGCTCGGG	CASP1	ENSG00000137752	0.14573445280704012	[241]	[225]	1	hSpCas9	negative selection	596821
105034207	105034230	11	-	26472758	K562	viability	GGGACGCTGGGACTCTCAGCAGG	CASP1	ENSG00000137752	-3.8144749613871216	[249]	[14]	-9	hSpCas9	negative selection	596832
105034430	105034453	11	-	26472758	K562	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	1.3242194388795665	[210]	[445]	9	hSpCas9	negative selection	597053
105031235	105031258	11	-	26472758	K562	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	0.7463714519275674	[619]	[877]	6	hSpCas9	negative selection	597054
105026291	105026314	11	+	26472758	K562	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	1.0177532848842286	[1746]	[2985]	8	hSpCas9	negative selection	597055
105026265	105026288	11	-	26472758	K562	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.3077358385917166	[1002]	[1047]	2	hSpCas9	negative selection	597056
105029692	105029715	11	-	26472758	K562	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	0.06384648202462602	[356]	[314]	0	hSpCas9	negative selection	597057
105031164	105031187	11	-	26472758	K562	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.14647367725448746	[776]	[725]	1	hSpCas9	negative selection	597058
105029802	105029825	11	-	26472758	K562	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	1.1106673387776196	[287]	[524]	8	hSpCas9	negative selection	597059
105029654	105029677	11	+	26472758	K562	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	-1.4756041208763153	[648]	[196]	-6	hSpCas9	negative selection	597060
105029667	105029690	11	-	26472758	K562	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	0.15036049388141637	[506]	[474]	1	hSpCas9	negative selection	597061
105031256	105031279	11	+	26472758	K562	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	0.829381228387603	[297]	[446]	7	hSpCas9	negative selection	597063
105029240	105029263	11	+	26627737	DLD1	viability	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.27086882950771285	[324]	[147,150,76]	3	hSpCas9	negative selection	776510
105029258	105029281	11	-	26627737	DLD1	viability	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	-0.1653038005232964	[433]	[184,94,86]	-2	hSpCas9	negative selection	776511
105029240	105029263	11	+	26627737	GBM cells	viability after 5 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	-0.8046931223340896	[227]	[67,71]	-8	hSpCas9	negative selection	858825
105029258	105029281	11	-	26627737	GBM cells	viability after 5 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	-0.32216521450672986	[182]	[111,44]	-5	hSpCas9	negative selection	858826
105029240	105029263	11	+	26627737	GBM cells	viability after 13 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	-0.2490217749786345	[227]	[161,56]	-3	hSpCas9	negative selection	941140
105029258	105029281	11	-	26627737	GBM cells	viability after 13 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	-0.16455350128400636	[182]	[92,84]	-2	hSpCas9	negative selection	941141
105029240	105029263	11	+	26627737	GBM cells	viability after 21 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	-0.17027727408882828	[227]	[119,100]	-1	hSpCas9	negative selection	1023455
105029258	105029281	11	-	26627737	GBM cells	viability after 21 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	-0.07645067170732245	[182]	[110,78]	0	hSpCas9	negative selection	1023456
105029240	105029263	11	+	26627737	RPE1	viability after 9 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.47667435316127815	[780]	[272,426]	3	hSpCas9	negative selection	1105770
105029258	105029281	11	-	26627737	RPE1	viability after 9 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	0.8285329315193412	[404]	[184,276]	5	hSpCas9	negative selection	1105771
105029240	105029263	11	+	26627737	RPE1	viability after 12 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.38601743442302205	[780]	[331,212]	2	hSpCas9	negative selection	1188085
105029258	105029281	11	-	26627737	RPE1	viability after 12 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	0.23368910980878177	[404]	[176,75]	1	hSpCas9	negative selection	1188086
105029240	105029263	11	+	26627737	RPE1	viability after 15 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.11495207154971948	[780]	[196,279]	0	hSpCas9	negative selection	1270400
105029258	105029281	11	-	26627737	RPE1	viability after 15 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	0.8361672035498837	[404]	[286,124]	5	hSpCas9	negative selection	1270401
105029240	105029263	11	+	26627737	RPE1	viability after 18 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.19059581504374778	[780]	[124,363]	1	hSpCas9	negative selection	1352715
105029258	105029281	11	-	26627737	RPE1	viability after 18 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	0.6944136814193743	[404]	[172,180]	4	hSpCas9	negative selection	1352716
105029240	105029263	11	+	26627737	HeLa	viability after 8 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.2332288297023269	[332]	[263,132,136]	2	hSpCas9	negative selection	1435030
105029258	105029281	11	-	26627737	HeLa	viability after 8 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	0.975020245369741	[95]	[65,82,92]	7	hSpCas9	negative selection	1435031
105029240	105029263	11	+	26627737	HeLa	viability after 12 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.21433099842051023	[332]	[219,175,82]	2	hSpCas9	negative selection	1517345
105029258	105029281	11	-	26627737	HeLa	viability after 12 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	1.4170423058037775	[95]	[47,78,191]	8	hSpCas9	negative selection	1517346
105029240	105029263	11	+	26627737	HeLa	viability after 15 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.4033747242411996	[332]	[204,147,184]	3	hSpCas9	negative selection	1599660
105029258	105029281	11	-	26627737	HeLa	viability after 15 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	1.5918850463418406	[95]	[117,158,72]	9	hSpCas9	negative selection	1599661
105029240	105029263	11	+	26627737	HeLa	viability after 18 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.39762746026099777	[332]	[138,118,184]	3	hSpCas9	negative selection	1681975
105029258	105029281	11	-	26627737	HeLa	viability after 18 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	1.6697084610056705	[95]	[89,133,72]	9	hSpCas9	negative selection	1681976
105029240	105029263	11	+	26627737	HCT116	viability after 6 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	-1.6767995001726934	[375]	[22,15]	-7	hSpCas9	negative selection	1764290
105029258	105029281	11	-	26627737	HCT116	viability after 6 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	-0.1248827128569937	[475]	[47,79]	0	hSpCas9	negative selection	1764291
105029240	105029263	11	+	26627737	HCT116	viability after 8 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.851195543848904	[179]	[203,134,197]	7	hSpCas9	negative selection	1846605
105029258	105029281	11	-	26627737	HCT116	viability after 8 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	-0.43354651071567124	[379]	[107,177,177]	-5	hSpCas9	negative selection	1846606
105029240	105029263	11	+	26627737	HCT116	viability after 9 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.2634520783607861	[375]	[24,195]	2	hSpCas9	negative selection	1928920
105029258	105029281	11	-	26627737	HCT116	viability after 9 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	-0.333161524280355	[475]	[120,84]	-2	hSpCas9	negative selection	1928921
105029240	105029263	11	+	26627737	HCT116	viability after 12 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.5585561495066356	[179]	[130,110,175]	5	hSpCas9	negative selection	2011235
105029258	105029281	11	-	26627737	HCT116	viability after 12 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	-0.7958486973287292	[379]	[88,140,117]	-7	hSpCas9	negative selection	2011236
105029240	105029263	11	+	26627737	HCT116	viability after 15 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.39969010172069636	[179]	[146,92,169]	4	hSpCas9	negative selection	2093550
105029258	105029281	11	-	26627737	HCT116	viability after 15 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	-1.1151686603111681	[379]	[68,180,48]	-8	hSpCas9	negative selection	2093551
105029240	105029263	11	+	26627737	HCT116	viability after 18 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.48981874044098583	[179]	[127,124,112]	4	hSpCas9	negative selection	2175865
105029258	105029281	11	-	26627737	HCT116	viability after 18 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	-1.7399219714281144	[379]	[30,81,49]	-8	hSpCas9	negative selection	2175866
105029830	105029852	11	-	24717434	HeLa	essential genes for diphteria toxin toxicity	ACCTCTGACAGCACGTTCCTGG	CASP1	ENSG00000137752	-0.5122709390791133	[3386,3594,3777]	[0,0,0]	-4	hSpCas9	positive selection	2380624
105034430	105034453	11	-	24717434	HeLa	essential genes for diphteria toxin toxicity	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.6589546205990112	[3645,4178,4078]	[0,0,0]	-6	hSpCas9	positive selection	2380625
105034382	105034404	11	-	24717434	HeLa	essential genes for diphteria toxin toxicity	GATGAATTATTACAGACAAGGG	CASP1	ENSG00000137752	-0.2317874984250454	[2893,3110,2861]	[0,0,0]	-2	hSpCas9	positive selection	2380626
105029830	105029852	11	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	ACCTCTGACAGCACGTTCCTGG	CASP1	ENSG00000137752	3.2602610442061684	[3386,3594,3777]	[0,38,0]	6	hSpCas9	positive selection	2381750
105029830	105029852	11	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	ACCTCTGACAGCACGTTCCTGG	CASP1	ENSG00000137752	3.2602610442061684	[3386,3594,3777]	[0,38,0]	6	hSpCas9	positive selection	2381751
105034430	105034453	11	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.6591912786037674	[3645,4178,4078]	[0,0,0]	-6	hSpCas9	positive selection	2381752
105034430	105034453	11	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.6591912786037674	[3645,4178,4078]	[0,0,0]	-6	hSpCas9	positive selection	2381753
105034382	105034404	11	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	GATGAATTATTACAGACAAGGG	CASP1	ENSG00000137752	-0.23217655927369482	[2893,3110,2861]	[0,0,0]	-2	hSpCas9	positive selection	2381754
105034382	105034404	11	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	GATGAATTATTACAGACAAGGG	CASP1	ENSG00000137752	-0.23217655927369482	[2893,3110,2861]	[0,0,0]	-2	hSpCas9	positive selection	2381755
105026265	105026288	11	-	27013184	SW480	treatment with recombinant TRAIL	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	-0.31909665575066004	[58,40]	[24,6]	-1	hSpCas9	positive selection	2960410
105034201	105034224	11	-	27013184	SW480	treatment with recombinant TRAIL	CTGGGACTCTCAGCAGGTAAGGG	CASP1	ENSG00000137752	-2.19142203134687	[681,1199]	[75,101]	-7	hSpCas9	positive selection	2960412
105034207	105034230	11	-	27013184	SW480	treatment with recombinant TRAIL	GGGACGCTGGGACTCTCAGCAGG	CASP1	ENSG00000137752	1.4168914105003518	[227,289]	[364,195]	6	hSpCas9	positive selection	2960417
105034219	105034242	11	-	27013184	SW480	treatment with recombinant TRAIL	AGTTACCTGGCAGGGACGCTGGG	CASP1	ENSG00000137752	2.080318006152445	[368,522]	[864,710]	8	hSpCas9	positive selection	2960418
105034220	105034243	11	-	27013184	SW480	treatment with recombinant TRAIL	CAGTTACCTGGCAGGGACGCTGG	CASP1	ENSG00000137752	-0.4614231245988004	[280,332]	[137,34]	-2	hSpCas9	positive selection	2960419
105034280	105034303	11	-	27013184	SW480	treatment with recombinant TRAIL	CGTTATTCCGAAAGGGGCACAGG	CASP1	ENSG00000137752	-0.5957109725751712	[73,82]	[18,26]	-3	hSpCas9	positive selection	2960420
105034286	105034309	11	-	27013184	SW480	treatment with recombinant TRAIL	TGACTCCGTTATTCCGAAAGGGG	CASP1	ENSG00000137752	-1.2982032496272673	[516,725]	[47,191]	-5	hSpCas9	positive selection	2960423
105034287	105034310	11	-	27013184	SW480	treatment with recombinant TRAIL	TTGACTCCGTTATTCCGAAAGGG	CASP1	ENSG00000137752	-1.2860118484593257	[563,540]	[66,141]	-5	hSpCas9	positive selection	2960424
105034288	105034311	11	-	27013184	SW480	treatment with recombinant TRAIL	ATTGACTCCGTTATTCCGAAAGG	CASP1	ENSG00000137752	0.016512409543518736	[232,377]	[125,136]	0	hSpCas9	positive selection	2960427
105034328	105034351	11	-	27013184	SW480	treatment with recombinant TRAIL	ACGTGAAAATGCTACAGTTATGG	CASP1	ENSG00000137752	1.1426643749971248	[318,316]	[300,305]	5	hSpCas9	positive selection	2960428
105034403	105034426	11	-	27013184	SW480	treatment with recombinant TRAIL	AGGTACAATAAATGGCTTACTGG	CASP1	ENSG00000137752	1.226634024632515	[69,179]	[169,51]	6	hSpCas9	positive selection	2960430
105034423	105034446	11	-	27013184	SW480	treatment with recombinant TRAIL	TTTATCCGTTCCATGGGTGAAGG	CASP1	ENSG00000137752	-0.40774105364263713	[399,428]	[159,97]	-2	hSpCas9	positive selection	2960434
105034429	105034452	11	-	27013184	SW480	treatment with recombinant TRAIL	AAGCTGTTTATCCGTTCCATGGG	CASP1	ENSG00000137752	0.05474927018584658	[208,384]	[115,148]	0	hSpCas9	positive selection	2960435
105034430	105034453	11	-	27013184	SW480	treatment with recombinant TRAIL	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	1.3798342683734652	[128,322]	[161,360]	6	hSpCas9	positive selection	2960436
105034460	105034483	11	-	27013184	SW480	treatment with recombinant TRAIL	CTAAACAGACAAGGTCCTGAAGG	CASP1	ENSG00000137752	-1.1522786033138055	[38,17]	[1,10]	-5	hSpCas9	positive selection	2960437
105034469	105034492	11	-	27013184	SW480	treatment with recombinant TRAIL	CCTTGTGCTCTAAACAGACAAGG	CASP1	ENSG00000137752	1.3744197854077074	[63,72]	[69,84]	6	hSpCas9	positive selection	2960438
105030455	105030478	11	+	27013184	SW480	treatment with recombinant TRAIL	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.4537560014774795	[72,75]	[38,50]	2	hSpCas9	positive selection	2960439
105030475	105030498	11	+	27013184	SW480	treatment with recombinant TRAIL	CGGCTTGACTTGTCCATTATTGG	CASP1	ENSG00000137752	2.0245738650667002	[451,708]	[836,1229]	8	hSpCas9	positive selection	2960440
105030488	105030511	11	+	27013184	SW480	treatment with recombinant TRAIL	CCATTATTGGATAAATCTGTAGG	CASP1	ENSG00000137752	-0.3384707986009381	[31,90]	[3,42]	-1	hSpCas9	positive selection	2960441
105026247	105026270	11	+	27013184	SW480	treatment with recombinant TRAIL	GTTTCCTTATTTTAATGTCCTGG	CASP1	ENSG00000137752	3.089366650195587	[64,35]	[124,282]	9	hSpCas9	positive selection	2960443
105026248	105026271	11	+	27013184	SW480	treatment with recombinant TRAIL	TTTCCTTATTTTAATGTCCTGGG	CASP1	ENSG00000137752	-0.9308144795397659	[80,130]	[13,36]	-4	hSpCas9	positive selection	2960444
105026288	105026311	11	+	27013184	SW480	treatment with recombinant TRAIL	TGTCAAAGTCACTCTTTCAGTGG	CASP1	ENSG00000137752	-0.9480512822602807	[242,151]	[35,57]	-4	hSpCas9	positive selection	2960445
105026291	105026314	11	+	27013184	SW480	treatment with recombinant TRAIL	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	0.12213981215585268	[324,434]	[228,100]	0	hSpCas9	positive selection	2960446
105034281	105034304	11	+	27013184	SW480	treatment with recombinant TRAIL	CTGTGCCCCTTTCGGAATAACGG	CASP1	ENSG00000137752	-1.1433371193023492	[253,373]	[56,64]	-5	hSpCas9	positive selection	2960448
105034298	105034321	11	+	27013184	SW480	treatment with recombinant TRAIL	TAACGGAGTCAATCAAAGCTCGG	CASP1	ENSG00000137752	0.24183774056347218	[44,43]	[11,37]	1	hSpCas9	positive selection	2960449
105034299	105034322	11	+	27013184	SW480	treatment with recombinant TRAIL	AACGGAGTCAATCAAAGCTCGGG	CASP1	ENSG00000137752	1.1526905166958028	[113,140]	[121,119]	5	hSpCas9	positive selection	2960451
105034413	105034436	11	+	27013184	SW480	treatment with recombinant TRAIL	ATTTATTGTACCTTCACCCATGG	CASP1	ENSG00000137752	-0.04477191799304717	[184,213]	[39,143]	0	hSpCas9	positive selection	2960453
105034418	105034441	11	+	27013184	SW480	treatment with recombinant TRAIL	TTGTACCTTCACCCATGGAACGG	CASP1	ENSG00000137752	1.5412782341574744	[9,83]	[44,68]	7	hSpCas9	positive selection	2960455
105035093	105035116	11	+	27013184	SW480	treatment with recombinant TRAIL	AGTAAAAGACTCACCGGCCATGG	CASP1	ENSG00000137752	-0.7683775065986378	[30,75]	[17,5]	-3	hSpCas9	positive selection	2960459
105035093	105035116	11	+	27013184	SW480	treatment with recombinant TRAIL	AGTAAAAGACTCACCGGCCATGG	CASP1	ENSG00000137752	-0.7766506409059908	[40,72]	[13,13]	-4	hSpCas9	positive selection	2960462
105026910	105026933	11	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ATAAAAACAGAGCCCATTGTGGG	CASP1	ENSG00000137752	0.0354922149937166	[4,3]	[3,3]	0	hSpCas9	positive selection	2976392
105034460	105034483	11	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CTAAACAGACAAGGTCCTGAAGG	CASP1	ENSG00000137752	-0.21202788554975194	[2,2]	[0,1]	-3	hSpCas9	positive selection	2976393
105034419	105034442	11	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTGTACCTTCACCCATGGAACGG	CASP1	ENSG00000137752	-0.0633705980386953	[2,3]	[2,1]	-1	hSpCas9	positive selection	2976394
105034423	105034446	11	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTTATCCGTTCCATGGGTGAAGG	CASP1	ENSG00000137752	-0.13766995195873322	[3,4]	[3,1]	-2	hSpCas9	positive selection	2976395
105026910	105026933	11	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ATAAAAACAGAGCCCATTGTGGG	CASP1	ENSG00000137752	-0.22796941764876405	[4,4]	[3,1]	-3	hSpCas9	positive selection	3044250
105034460	105034483	11	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CTAAACAGACAAGGTCCTGAAGG	CASP1	ENSG00000137752	0.5979070287949413	[2,2]	[2,2]	8	hSpCas9	positive selection	3044251
105034419	105034442	11	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTGTACCTTCACCCATGGAACGG	CASP1	ENSG00000137752	0.28508710242353413	[2,2]	[5,0]	5	hSpCas9	positive selection	3044252
105034423	105034446	11	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTTATCCGTTCCATGGGTGAAGG	CASP1	ENSG00000137752	0.27563770757421124	[3,3]	[3,2]	5	hSpCas9	positive selection	3044253
105034430	105034453		-	24336571	A375	resistance to PLX after 7 days	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.06363624500265899	[10,11]	[10,12]	2	hSpCas9	positive selection	3160700
105026906	105026929		-	24336571	A375	resistance to PLX after 7 days	ACAATGGGCTCTGTTTTTATTGG	CASP1	ENSG00000137752	-0.047660876709447075	[8,10]	[8,9]	-1	hSpCas9	positive selection	3160701
105034460	105034483		-	24336571	A375	resistance to PLX after 7 days	CTAAACAGACAAGGTCCTGAAGG	CASP1	ENSG00000137752	0.012797634247874168	[19,18]	[18,20]	0	hSpCas9	positive selection	3160702
105033085	105033108		+	24336571	A375	resistance to PLX after 7 days	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	-0.39221923938976877	[10,8]	[6,7]	-9	hSpCas9	positive selection	3160704
105031219	105031242		+	24336571	A375	resistance to PLX after 7 days	GACATTCCCTTCTGAGCCTGAGG	CASP1	ENSG00000137752	-0.030701895943699098	[55,44]	[49,47]	-1	hSpCas9	positive selection	3160705
105031189	105031212		-	24336571	A375	resistance to PLX after 7 days	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.13839803705513498	[4,4]	[5,4]	4	hSpCas9	positive selection	3160706
105026938	105026961		-	24336571	A375	resistance to PLX after 7 days	TATCCATAGATAATGTTTCTTGG	CASP1	ENSG00000137752	-0.292699293829575	[10,10]	[7,8]	-8	hSpCas9	positive selection	3160707
105034430	105034453		-	24336571	A375	resistance to PLX after 14 days	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.6160712741392707	[8,10]	[6,7]	5	hSpCas9	positive selection	3218493
105026906	105026929		-	24336571	A375	resistance to PLX after 14 days	ACAATGGGCTCTGTTTTTATTGG	CASP1	ENSG00000137752	-0.285126198886239	[6,17]	[2,5]	-3	hSpCas9	positive selection	3218494
105034460	105034483		-	24336571	A375	resistance to PLX after 14 days	CTAAACAGACAAGGTCCTGAAGG	CASP1	ENSG00000137752	-0.7470165458137719	[19,16]	[4,4]	-8	hSpCas9	positive selection	3218495
105033085	105033108		+	24336571	A375	resistance to PLX after 14 days	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	-0.21785198808205597	[10,4]	[2,2]	-2	hSpCas9	positive selection	3218497
105031219	105031242		+	24336571	A375	resistance to PLX after 14 days	GACATTCCCTTCTGAGCCTGAGG	CASP1	ENSG00000137752	-0.06870148781611318	[44,50]	[18,23]	0	hSpCas9	positive selection	3218498
105031189	105031212		-	24336571	A375	resistance to PLX after 14 days	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.4912501686388868	[3,4]	[2,2]	4	hSpCas9	positive selection	3218499
105026938	105026961		-	24336571	A375	resistance to PLX after 14 days	TATCCATAGATAATGTTTCTTGG	CASP1	ENSG00000137752	0.20658629973669665	[8,9]	[4,4]	2	hSpCas9	positive selection	3218500
105034430	105034453		-	24336571	A375	viability after 7 days	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.8099427272170908	[6]	[10,11]	9	hSpCas9	negative selection	3276286
105026906	105026929		-	24336571	A375	viability after 7 days	ACAATGGGCTCTGTTTTTATTGG	CASP1	ENSG00000137752	0.0856654225311198	[9]	[8,10]	1	hSpCas9	negative selection	3276287
105034460	105034483		-	24336571	A375	viability after 7 days	CTAAACAGACAAGGTCCTGAAGG	CASP1	ENSG00000137752	-0.6314847668150844	[31]	[19,18]	-7	hSpCas9	negative selection	3276288
105033085	105033108		+	24336571	A375	viability after 7 days	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	-0.022469978377927136	[10]	[10,8]	0	hSpCas9	negative selection	3276290
105031219	105031242		+	24336571	A375	viability after 7 days	GACATTCCCTTCTGAGCCTGAGG	CASP1	ENSG00000137752	0.31380286002898994	[42]	[55,44]	5	hSpCas9	negative selection	3276291
105031189	105031212		-	24336571	A375	viability after 7 days	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.27568011667248604	[3]	[4,4]	4	hSpCas9	negative selection	3276292
105026938	105026961		-	24336571	A375	viability after 7 days	TATCCATAGATAATGTTTCTTGG	CASP1	ENSG00000137752	-0.12978823309288395	[11]	[10,10]	-2	hSpCas9	negative selection	3276293
105034430	105034453		-	24336571	A375	viability after 14 days	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.6542404679168174	[6]	[8,10]	8	hSpCas9	negative selection	3334079
105026906	105026929		-	24336571	A375	viability after 14 days	ACAATGGGCTCTGTTTTTATTGG	CASP1	ENSG00000137752	0.37537264931566716	[9]	[6,17]	5	hSpCas9	negative selection	3334080
105034460	105034483		-	24336571	A375	viability after 14 days	CTAAACAGACAAGGTCCTGAAGG	CASP1	ENSG00000137752	-0.6817605211003966	[31]	[19,16]	-7	hSpCas9	negative selection	3334081
105033085	105033108		+	24336571	A375	viability after 14 days	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	-0.23912951371687013	[10]	[10,4]	-3	hSpCas9	negative selection	3334083
105031219	105031242		+	24336571	A375	viability after 14 days	GACATTCCCTTCTGAGCCTGAGG	CASP1	ENSG00000137752	0.2635625774344026	[42]	[44,50]	3	hSpCas9	negative selection	3334084
105031189	105031212		-	24336571	A375	viability after 14 days	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.16050179540221365	[3]	[3,4]	2	hSpCas9	negative selection	3334085
105026938	105026961		-	24336571	A375	viability after 14 days	TATCCATAGATAATGTTTCTTGG	CASP1	ENSG00000137752	-0.25906925950199006	[11]	[8,9]	-3	hSpCas9	negative selection	3334086
105030415	105030438	11	-	27383988	293T	resistance to West Nile virus (flavivirus)	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	2.5576120125762007	[23,27]	[0,0]	8	hSpCas9	positive selection	3341107
105030455	105030478	11	+	27383988	293T	resistance to West Nile virus (flavivirus)	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.984945007782147	[273,331]	[0,0]	-6	hSpCas9	positive selection	3341108
105031189	105031212	11	-	27383988	293T	resistance to West Nile virus (flavivirus)	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	-1.2283584272790598	[352,363]	[0,0]	-7	hSpCas9	positive selection	3341109
105034430	105034453	11	-	27383988	293T	resistance to West Nile virus (flavivirus)	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	1.672363710724679	[47,47]	[0,0]	6	hSpCas9	positive selection	3360355
105031164	105031187	11	-	27383988	293T	resistance to West Nile virus (flavivirus)	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.5849008694743394	[101,101]	[0,0]	3	hSpCas9	positive selection	3360356
105033085	105033108	11	+	27383988	293T	resistance to West Nile virus (flavivirus)	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	-1.0187981938284023	[309,309]	[0,0]	-6	hSpCas9	positive selection	3360357
105026909	105026932	11	+	26780180	HT29	viability (Avana library 4 designs)	ATAAAAACAGAGCCCATTGTGGG	CASP1	ENSG00000137752	1.20468979542124	[]	[]	5	hSpCas9	negative selection	3412673
105034460	105034483	11	-	26780180	HT29	viability (Avana library 4 designs)	CTAAACAGACAAGGTCCTGAAGG	CASP1	ENSG00000137752	0.972011167911851	[]	[]	4	hSpCas9	negative selection	3412674
105034418	105034441	11	+	26780180	HT29	viability (Avana library 4 designs)	TTGTACCTTCACCCATGGAACGG	CASP1	ENSG00000137752	1.6229375464206	[]	[]	6	hSpCas9	negative selection	3412675
105034423	105034446	11	-	26780180	HT29	viability (Avana library 4 designs)	TTTATCCGTTCCATGGGTGAAGG	CASP1	ENSG00000137752	0.249196272436036	[]	[]	0	hSpCas9	negative selection	3412676
105026909	105026932	11	+	26780180	A375	viability (Avana lentiCRISPRv2)	ATAAAAACAGAGCCCATTGTGGG	CASP1	ENSG00000137752	1.78782094579018	[]	[]	2	hSpCas9	negative selection	3488255
105034423	105034446	11	-	26780180	A375	viability (Avana lentiCRISPRv2)	TTTATCCGTTCCATGGGTGAAGG	CASP1	ENSG00000137752	2.20783937685273	[]	[]	3	hSpCas9	negative selection	3488256
105034460	105034483	11	-	26780180	A375	viability (Avana lentiCRISPRv2)	CTAAACAGACAAGGTCCTGAAGG	CASP1	ENSG00000137752	-8.34195732433185	[]	[]	-7	hSpCas9	negative selection	3488257
105034418	105034441	11	+	26780180	A375	viability (Avana lentiCRISPRv2)	TTGTACCTTCACCCATGGAACGG	CASP1	ENSG00000137752	-3.84823028334967	[]	[]	-4	hSpCas9	negative selection	3488258
105035106	105035129	11	-	26780180	A375	viability (Avana lentiCRISPRv2)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	-0.721122252560106	[]	[]	-1	hSpCas9	negative selection	3488259
105035106	105035129	11	-	26780180	A375	viability (Avana lentiCRISPRv2)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	-0.721122252560106	[]	[]	-1	hSpCas9	negative selection	3488260
105035106	105035129	11	-	26780180	A375	viability (Avana lentiCRISPRv2)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	1.61553934022608	[]	[]	2	hSpCas9	negative selection	3488261
105035106	105035129	11	-	26780180	A375	viability (Avana lentiCRISPRv2)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	1.61553934022608	[]	[]	2	hSpCas9	negative selection	3488262
105035093	105035116	11	+	26780180	A375	viability (Avana lentiCRISPRv2)	AGTAAAAGACTCACCGGCCATGG	CASP1	ENSG00000137752	2.82054991811211	[]	[]	4	hSpCas9	negative selection	3488263
105026909	105026932	11	+	26780180	A375	viability (Avana lentiGuide)	ATAAAAACAGAGCCCATTGTGGG	CASP1	ENSG00000137752	-6.13819883051045	[]	[]	-9	hSpCas9	negative selection	3596914
105034423	105034446	11	-	26780180	A375	viability (Avana lentiGuide)	TTTATCCGTTCCATGGGTGAAGG	CASP1	ENSG00000137752	2.72987039392146	[]	[]	3	hSpCas9	negative selection	3596915
105034460	105034483	11	-	26780180	A375	viability (Avana lentiGuide)	CTAAACAGACAAGGTCCTGAAGG	CASP1	ENSG00000137752	9.06154765925432	[]	[]	6	hSpCas9	negative selection	3596916
105034418	105034441	11	+	26780180	A375	viability (Avana lentiGuide)	TTGTACCTTCACCCATGGAACGG	CASP1	ENSG00000137752	7.2680038593512	[]	[]	6	hSpCas9	negative selection	3596917
105035106	105035129	11	-	26780180	A375	viability (Avana lentiGuide)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	-1.46393090544102	[]	[]	-2	hSpCas9	negative selection	3596918
105035106	105035129	11	-	26780180	A375	viability (Avana lentiGuide)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	-1.46393090544102	[]	[]	-2	hSpCas9	negative selection	3596919
105035106	105035129	11	-	26780180	A375	viability (Avana lentiGuide)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	2.07408717954934	[]	[]	2	hSpCas9	negative selection	3596920
105035106	105035129	11	-	26780180	A375	viability (Avana lentiGuide)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	2.07408717954934	[]	[]	2	hSpCas9	negative selection	3596921
105035093	105035116	11	+	26780180	A375	viability (Avana lentiGuide)	AGTAAAAGACTCACCGGCCATGG	CASP1	ENSG00000137752	5.31611943996548	[]	[]	5	hSpCas9	negative selection	3596922
105026909	105026932	11	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATAAAAACAGAGCCCATTGTGGG	CASP1	ENSG00000137752	0.10965845211959696	[5]	[6,6]	3	hSpCas9	positive selection	3705573
105034423	105034446	11	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTTATCCGTTCCATGGGTGAAGG	CASP1	ENSG00000137752	0.10344226787582111	[5]	[6,5]	2	hSpCas9	positive selection	3705574
105034460	105034483	11	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTAAACAGACAAGGTCCTGAAGG	CASP1	ENSG00000137752	-1.1465491960094105	[4]	[1,0]	-9	hSpCas9	positive selection	3705575
105034418	105034441	11	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTGTACCTTCACCCATGGAACGG	CASP1	ENSG00000137752	-0.7939582899204797	[5]	[3,1]	-8	hSpCas9	positive selection	3705576
105035106	105035129	11	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	0.0388953766625475	[5]	[6,5]	1	hSpCas9	positive selection	3705577
105035106	105035129	11	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	0.0388953766625475	[4]	[4,3]	1	hSpCas9	positive selection	3705578
105035106	105035129	11	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	0.08891539859787875	[5]	[6,5]	2	hSpCas9	positive selection	3705579
105035093	105035116	11	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGTAAAAGACTCACCGGCCATGG	CASP1	ENSG00000137752	0.08891539859787875	[6]	[7,7]	2	hSpCas9	positive selection	3705580
105035106	105035129	11	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	0.08891539859787875	[4]	[4,3]	2	hSpCas9	positive selection	3705581
105026909	105026932	11	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATAAAAACAGAGCCCATTGTGGG	CASP1	ENSG00000137752	0.4421343718159351	[5]	[6,5]	9	hSpCas9	positive selection	3814180
105034423	105034446	11	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTTATCCGTTCCATGGGTGAAGG	CASP1	ENSG00000137752	-0.47244489555025015	[5]	[4,2]	-6	hSpCas9	positive selection	3814181
105034460	105034483	11	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTAAACAGACAAGGTCCTGAAGG	CASP1	ENSG00000137752	-0.13760487461359927	[3]	[3,1]	-2	hSpCas9	positive selection	3814182
105034418	105034441	11	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTGTACCTTCACCCATGGAACGG	CASP1	ENSG00000137752	-0.019733649038375378	[4]	[3,4]	0	hSpCas9	positive selection	3814183
105035106	105035129	11	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	0.18289467700058076	[6]	[6,5]	4	hSpCas9	positive selection	3814184
105035106	105035129	11	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	0.18289467700058076	[5]	[4,5]	4	hSpCas9	positive selection	3814185
105035106	105035129	11	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	0.15586160271327584	[6]	[6,5]	3	hSpCas9	positive selection	3814186
105035093	105035116	11	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGTAAAAGACTCACCGGCCATGG	CASP1	ENSG00000137752	0.15586160271327584	[7]	[6,6]	3	hSpCas9	positive selection	3814187
105035106	105035129	11	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GAGGAGAGAAAAGCCATGGCCGG	CASP1	ENSG00000137752	0.15586160271327584	[5]	[4,5]	3	hSpCas9	positive selection	3814188
105034430	105034453	11	-	26780180	A375	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.899576675815879	[]	[]	4	hSpCas9	negative selection	3922483
105031164	105031187	11	-	26780180	A375	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.660801981045053	[]	[]	2	hSpCas9	negative selection	3922484
105033085	105033108	11	+	26780180	A375	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	-0.502109137847408	[]	[]	-9	hSpCas9	negative selection	3922485
105030415	105030438	11	-	26780180	A375	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	1.83577613831542	[]	[]	9	hSpCas9	negative selection	3922486
105031189	105031212	11	-	26780180	A375	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.419915205255211	[]	[]	1	hSpCas9	negative selection	3922487
105030455	105030478	11	+	26780180	A375	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	1.06427315518071	[]	[]	5	hSpCas9	negative selection	3922488
105034430	105034453	11	-	26780180	HT29	viability (GeCKOv2 library)	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	1.14077993176008	[]	[]	5	hSpCas9	negative selection	4030449
105031164	105031187	11	-	26780180	HT29	viability (GeCKOv2 library)	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.660562419497656	[]	[]	2	hSpCas9	negative selection	4030450
105033085	105033108	11	+	26780180	HT29	viability (GeCKOv2 library)	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.0595453178942852	[]	[]	0	hSpCas9	negative selection	4030451
105030415	105030438	11	-	26780180	HT29	viability (GeCKOv2 library)	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	2.2201707460615	[]	[]	9	hSpCas9	negative selection	4030452
105031189	105031212	11	-	26780180	HT29	viability (GeCKOv2 library)	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.439526831338917	[]	[]	1	hSpCas9	negative selection	4030453
105030455	105030478	11	+	26780180	HT29	viability (GeCKOv2 library)	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.281811945692512	[]	[]	0	hSpCas9	negative selection	4030454
105034430	105034453	11	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.07707832675345799	[5]	[3,2]	-2	hSpCas9	positive selection	4188792
105026906	105026929	11	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ACAATGGGCTCTGTTTTTATTGG	CASP1	ENSG00000137752	-0.25101617712332064	[3]	[1,1]	-6	hSpCas9	positive selection	4188793
105034460	105034483	11	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTAAACAGACAAGGTCCTGAAGG	CASP1	ENSG00000137752	-0.22578113550615753	[4]	[2,2]	-5	hSpCas9	positive selection	4188794
105033085	105033108	11	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	-0.20043347948132012	[3]	[1,1]	-5	hSpCas9	positive selection	4188796
105031219	105031242	11	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GACATTCCCTTCTGAGCCTGAGG	CASP1	ENSG00000137752	0.18996284619449755	[5]	[4,4]	5	hSpCas9	positive selection	4188797
105031189	105031212	11	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	-0.32194399024051196	[2]	[1,1]	-7	hSpCas9	positive selection	4188798
105026938	105026961	11	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TATCCATAGATAATGTTTCTTGG	CASP1	ENSG00000137752	-0.07515133960133169	[2]	[1,2]	-2	hSpCas9	positive selection	4188799
105034430	105034453	11	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.8588643049751108	[4]	[2,2,3,3]	5	hSpCas9	positive selection	4252814
105026906	105026929	11	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ACAATGGGCTCTGTTTTTATTGG	CASP1	ENSG00000137752	-0.17388148129677994	[2]	[1,0,1,0]	-3	hSpCas9	positive selection	4252815
105034460	105034483	11	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTAAACAGACAAGGTCCTGAAGG	CASP1	ENSG00000137752	1.2164356725820586	[5]	[3,3,4,6]	8	hSpCas9	positive selection	4252816
105033085	105033108	11	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.8445322324780495	[3]	[0,0,0,4]	5	hSpCas9	positive selection	4252818
105031219	105031242	11	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GACATTCCCTTCTGAGCCTGAGG	CASP1	ENSG00000137752	1.0291430819910206	[5]	[4,3,5,5]	7	hSpCas9	positive selection	4252819
105031189	105031212	11	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	-0.9776491313896793	[4]	[0,0,1,0]	-9	hSpCas9	positive selection	4252820
105026938	105026961	11	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TATCCATAGATAATGTTTCTTGG	CASP1	ENSG00000137752	0.7888606684539959	[4]	[1,1,2,3]	5	hSpCas9	positive selection	4252821
105030415	105030438	11	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.4957095833721481	[2]	[1,0]	-8	hSpCas9	positive selection	4260995
105030455	105030478	11	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.25331357201062815	[4]	[4,3]	5	hSpCas9	positive selection	4260996
105031189	105031212	11	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.5789275502113771	[4]	[4,5]	9	hSpCas9	positive selection	4260997
105034430	105034453	11	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.18107355398346003	[1]	[1,0]	-4	hSpCas9	positive selection	4325273
105031164	105031187	11	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.09942169594709838	[2]	[2,1]	-2	hSpCas9	positive selection	4325274
105033085	105033108	11	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.8473377647065767	[3]	[4,5]	9	hSpCas9	positive selection	4325275
105026841	105026863	11	-	27760321	OCIAML3	viability	GTGGAGGAAATTTTCCGCAAGG	CASP1	ENSG00000137752	0.16496632938721278	[189,161]	[122,193]	2	hSpCas9	negative selection	4385766
105026909	105026931	11	+	27760321	OCIAML3	viability	ATAAAAACAGAGCCCATTGTGG	CASP1	ENSG00000137752	-0.23674368256837885	[150,126]	[87,96]	-3	hSpCas9	negative selection	4385767
105026921	105026943	11	-	27760321	OCIAML3	viability	CTTGGAGACATCCCACAATGGG	CASP1	ENSG00000137752	0.03300786321066329	[292,238]	[206,217]	0	hSpCas9	negative selection	4385768
105029250	105029272	11	+	27760321	OCIAML3	viability	ACACCACACCAGGGCTGTCTGG	CASP1	ENSG00000137752	1.2938609692797562	[873,653]	[1053,1971]	9	hSpCas9	negative selection	4385769
105029695	105029717	11	+	27760321	OCIAML3	viability	TCGGTTTGTCCTTCAAACTTGG	CASP1	ENSG00000137752	0.25264656436636157	[285,252]	[264,231]	3	hSpCas9	negative selection	4385770
105029802	105029824	11	-	27760321	OCIAML3	viability	TGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	0.625500447860528	[410,399]	[363,654]	7	hSpCas9	negative selection	4385771
105029846	105029868	11	+	27760321	OCIAML3	viability	AGAGGTCTTGTGCTCTGGGCGG	CASP1	ENSG00000137752	-0.02724492234341014	[795,712]	[540,626]	0	hSpCas9	negative selection	4385772
105029881	105029903	11	-	27760321	OCIAML3	viability	CAGGACATGACTACAGAGCTGG	CASP1	ENSG00000137752	-1.106137392860838	[457,352]	[104,199]	-7	hSpCas9	negative selection	4385773
105030368	105030390	11	-	27760321	OCIAML3	viability	ACAATGCTGCTACAAAATCTGG	CASP1	ENSG00000137752	0.3563671647919802	[327,283]	[282,334]	4	hSpCas9	negative selection	4385774
105030415	105030437	11	-	27760321	OCIAML3	viability	ACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.751608450194345	[46,43]	[31,6]	-6	hSpCas9	negative selection	4385775
105030476	105030498	11	+	27760321	OCIAML3	viability	GGCTTGACTTGTCCATTATTGG	CASP1	ENSG00000137752	0.659332863126678	[259,254]	[307,332]	7	hSpCas9	negative selection	4385776
105034286	105034308	11	-	27760321	OCIAML3	viability	GACTCCGTTATTCCGAAAGGGG	CASP1	ENSG00000137752	-0.22956762921746265	[176,164]	[127,95]	-2	hSpCas9	negative selection	4385777
105033114	105033136	11	-	27760321	OCIAML3	viability	TTTTCATAGATCAAACATCTGG	CASP1	ENSG00000137752	1.0235417764176007	[39,23]	[49,49]	9	hSpCas9	negative selection	4385778
105026841	105026863	11	-	27760321	OCIAML2	viability	GTGGAGGAAATTTTCCGCAAGG	CASP1	ENSG00000137752	0.7810160185201499	[189,161]	[201,298]	9	hSpCas9	negative selection	4469229
105026909	105026931	11	+	27760321	OCIAML2	viability	ATAAAAACAGAGCCCATTGTGG	CASP1	ENSG00000137752	-0.9029959301950039	[150,126]	[52,68]	-7	hSpCas9	negative selection	4469230
105026921	105026943	11	-	27760321	OCIAML2	viability	CTTGGAGACATCCCACAATGGG	CASP1	ENSG00000137752	0.49693225239772965	[292,238]	[302,300]	6	hSpCas9	negative selection	4469231
105029250	105029272	11	+	27760321	OCIAML2	viability	ACACCACACCAGGGCTGTCTGG	CASP1	ENSG00000137752	0.5465222276429391	[873,653]	[812,1002]	7	hSpCas9	negative selection	4469232
105029695	105029717	11	+	27760321	OCIAML2	viability	TCGGTTTGTCCTTCAAACTTGG	CASP1	ENSG00000137752	0.4376015136976094	[285,252]	[267,329]	6	hSpCas9	negative selection	4469233
105029802	105029824	11	-	27760321	OCIAML2	viability	TGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	-0.0640201158889953	[410,399]	[348,268]	-1	hSpCas9	negative selection	4469234
105029846	105029868	11	+	27760321	OCIAML2	viability	AGAGGTCTTGTGCTCTGGGCGG	CASP1	ENSG00000137752	-0.2812038350856577	[795,712]	[489,516]	-3	hSpCas9	negative selection	4469235
105029881	105029903	11	-	27760321	OCIAML2	viability	CAGGACATGACTACAGAGCTGG	CASP1	ENSG00000137752	-0.17121207167426158	[457,352]	[261,324]	-2	hSpCas9	negative selection	4469236
105030368	105030390	11	-	27760321	OCIAML2	viability	ACAATGCTGCTACAAAATCTGG	CASP1	ENSG00000137752	0.5291078479614792	[327,283]	[398,299]	7	hSpCas9	negative selection	4469237
105030415	105030437	11	-	27760321	OCIAML2	viability	ACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	0.9959619803542803	[46,43]	[69,77]	9	hSpCas9	negative selection	4469238
105030476	105030498	11	+	27760321	OCIAML2	viability	GGCTTGACTTGTCCATTATTGG	CASP1	ENSG00000137752	0.3699927076632975	[259,254]	[287,245]	5	hSpCas9	negative selection	4469239
105034286	105034308	11	-	27760321	OCIAML2	viability	GACTCCGTTATTCCGAAAGGGG	CASP1	ENSG00000137752	-0.5999914318385295	[176,164]	[67,121]	-6	hSpCas9	negative selection	4469240
105033114	105033136	11	-	27760321	OCIAML2	viability	TTTTCATAGATCAAACATCTGG	CASP1	ENSG00000137752	-0.7135123589939663	[39,23]	[2,31]	-6	hSpCas9	negative selection	4469241
105026841	105026863	11	-	27760321	MV411	viability	GTGGAGGAAATTTTCCGCAAGG	CASP1	ENSG00000137752	1.2334374145296596	[189,161]	[266,279]	8	hSpCas9	negative selection	4552692
105026909	105026931	11	+	27760321	MV411	viability	ATAAAAACAGAGCCCATTGTGG	CASP1	ENSG00000137752	0.42467739085782563	[150,126]	[186,25]	3	hSpCas9	negative selection	4552693
105026921	105026943	11	-	27760321	MV411	viability	CTTGGAGACATCCCACAATGGG	CASP1	ENSG00000137752	1.4049630487890732	[292,238]	[565,306]	8	hSpCas9	negative selection	4552694
105029250	105029272	11	+	27760321	MV411	viability	ACACCACACCAGGGCTGTCTGG	CASP1	ENSG00000137752	1.5697652851727344	[873,653]	[1568,1355]	9	hSpCas9	negative selection	4552695
105029695	105029717	11	+	27760321	MV411	viability	TCGGTTTGTCCTTCAAACTTGG	CASP1	ENSG00000137752	1.5263594726615688	[285,252]	[510,511]	9	hSpCas9	negative selection	4552696
105029802	105029824	11	-	27760321	MV411	viability	TGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	1.5204386524093658	[410,399]	[917,545]	9	hSpCas9	negative selection	4552697
105029846	105029868	11	+	27760321	MV411	viability	AGAGGTCTTGTGCTCTGGGCGG	CASP1	ENSG00000137752	-0.000516129554516076	[795,712]	[381,669]	0	hSpCas9	negative selection	4552698
105029881	105029903	11	-	27760321	MV411	viability	CAGGACATGACTACAGAGCTGG	CASP1	ENSG00000137752	-0.7656672480376892	[457,352]	[198,91]	-5	hSpCas9	negative selection	4552699
105030368	105030390	11	-	27760321	MV411	viability	ACAATGCTGCTACAAAATCTGG	CASP1	ENSG00000137752	0.3286684995547132	[327,283]	[168,378]	2	hSpCas9	negative selection	4552700
105030415	105030437	11	-	27760321	MV411	viability	ACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-1.8743763477258515	[46,43]	[0,18]	-8	hSpCas9	negative selection	4552701
105030476	105030498	11	+	27760321	MV411	viability	GGCTTGACTTGTCCATTATTGG	CASP1	ENSG00000137752	1.2399673198580035	[259,254]	[339,495]	8	hSpCas9	negative selection	4552702
105034286	105034308	11	-	27760321	MV411	viability	GACTCCGTTATTCCGAAAGGGG	CASP1	ENSG00000137752	-2.3986809153047832	[176,164]	[30,6]	-8	hSpCas9	negative selection	4552703
105033114	105033136	11	-	27760321	MV411	viability	TTTTCATAGATCAAACATCTGG	CASP1	ENSG00000137752	1.6772916544512935	[39,23]	[33,114]	9	hSpCas9	negative selection	4552704
105026841	105026863	11	-	27760321	HL60	viability	GTGGAGGAAATTTTCCGCAAGG	CASP1	ENSG00000137752	0.8446864867228061	[189,161]	[235,279]	8	hSpCas9	negative selection	4636155
105026909	105026931	11	+	27760321	HL60	viability	ATAAAAACAGAGCCCATTGTGG	CASP1	ENSG00000137752	0.38883648107668933	[150,126]	[134,161]	5	hSpCas9	negative selection	4636156
105026921	105026943	11	-	27760321	HL60	viability	CTTGGAGACATCCCACAATGGG	CASP1	ENSG00000137752	-0.29153723672139464	[292,238]	[263,83]	-3	hSpCas9	negative selection	4636157
105029250	105029272	11	+	27760321	HL60	viability	ACACCACACCAGGGCTGTCTGG	CASP1	ENSG00000137752	0.4635153752179373	[873,653]	[760,950]	5	hSpCas9	negative selection	4636158
105029695	105029717	11	+	27760321	HL60	viability	TCGGTTTGTCCTTCAAACTTGG	CASP1	ENSG00000137752	0.21720780153466157	[285,252]	[237,273]	2	hSpCas9	negative selection	4636159
105029802	105029824	11	-	27760321	HL60	viability	TGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	0.4388630901668362	[410,399]	[316,590]	5	hSpCas9	negative selection	4636160
105029846	105029868	11	+	27760321	HL60	viability	AGAGGTCTTGTGCTCTGGGCGG	CASP1	ENSG00000137752	0.12561830433698828	[795,712]	[524,826]	1	hSpCas9	negative selection	4636161
105029881	105029903	11	-	27760321	HL60	viability	CAGGACATGACTACAGAGCTGG	CASP1	ENSG00000137752	-0.31051574757847	[457,352]	[335,189]	-4	hSpCas9	negative selection	4636162
105030368	105030390	11	-	27760321	HL60	viability	ACAATGCTGCTACAAAATCTGG	CASP1	ENSG00000137752	0.2565803044181952	[327,283]	[308,285]	3	hSpCas9	negative selection	4636163
105030415	105030437	11	-	27760321	HL60	viability	ACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.24212907724443689	[46,43]	[12,50]	-3	hSpCas9	negative selection	4636164
105030476	105030498	11	+	27760321	HL60	viability	GGCTTGACTTGTCCATTATTGG	CASP1	ENSG00000137752	-0.060857227792770474	[259,254]	[223,178]	0	hSpCas9	negative selection	4636165
105034286	105034308	11	-	27760321	HL60	viability	GACTCCGTTATTCCGAAAGGGG	CASP1	ENSG00000137752	-0.7003617561662039	[176,164]	[85,85]	-6	hSpCas9	negative selection	4636166
105033114	105033136	11	-	27760321	HL60	viability	TTTTCATAGATCAAACATCTGG	CASP1	ENSG00000137752	0.34121070521688024	[39,23]	[33,30]	4	hSpCas9	negative selection	4636167
105026841	105026863	11	-	27760321	HT1080	viability	GTGGAGGAAATTTTCCGCAAGG	CASP1	ENSG00000137752	1.1278569113407768	[161,126]	[37,221]	6	hSpCas9	negative selection	4719618
105026909	105026931	11	+	27760321	HT1080	viability	ATAAAAACAGAGCCCATTGTGG	CASP1	ENSG00000137752	-1.6476829395540205	[126,98]	[0,28]	-5	hSpCas9	negative selection	4719619
105026921	105026943	11	-	27760321	HT1080	viability	CTTGGAGACATCCCACAATGGG	CASP1	ENSG00000137752	-1.5175891111881334	[238,186]	[0,60]	-5	hSpCas9	negative selection	4719620
105029250	105029272	11	+	27760321	HT1080	viability	ACACCACACCAGGGCTGTCTGG	CASP1	ENSG00000137752	1.1889729073349309	[653,510]	[393,676]	6	hSpCas9	negative selection	4719621
105029695	105029717	11	+	27760321	HT1080	viability	TCGGTTTGTCCTTCAAACTTGG	CASP1	ENSG00000137752	0.39195279104653763	[252,197]	[62,177]	2	hSpCas9	negative selection	4719622
105029802	105029824	11	-	27760321	HT1080	viability	TGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	1.110197885927902	[399,311]	[403,198]	6	hSpCas9	negative selection	4719623
105029846	105029868	11	+	27760321	HT1080	viability	AGAGGTCTTGTGCTCTGGGCGG	CASP1	ENSG00000137752	-0.6947420668561974	[712,556]	[151,160]	-3	hSpCas9	negative selection	4719624
105029881	105029903	11	-	27760321	HT1080	viability	CAGGACATGACTACAGAGCTGG	CASP1	ENSG00000137752	0.7405264141391623	[352,275]	[279,131]	4	hSpCas9	negative selection	4719625
105030368	105030390	11	-	27760321	HT1080	viability	ACAATGCTGCTACAAAATCTGG	CASP1	ENSG00000137752	0.40136343705292793	[283,221]	[177,83]	2	hSpCas9	negative selection	4719626
105030415	105030437	11	-	27760321	HT1080	viability	ACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-1.3336063041177635	[43,34]	[0,11]	-5	hSpCas9	negative selection	4719627
105030476	105030498	11	+	27760321	HT1080	viability	GGCTTGACTTGTCCATTATTGG	CASP1	ENSG00000137752	1.2836186266858711	[254,198]	[138,308]	7	hSpCas9	negative selection	4719628
105034286	105034308	11	-	27760321	HT1080	viability	GACTCCGTTATTCCGAAAGGGG	CASP1	ENSG00000137752	-0.28956325184348786	[164,128]	[3,95]	-1	hSpCas9	negative selection	4719629
105033114	105033136	11	-	27760321	HT1080	viability	TTTTCATAGATCAAACATCTGG	CASP1	ENSG00000137752	3.570879819038235	[23,18]	[193,0]	9	hSpCas9	negative selection	4719630
105026841	105026863	11	-	27760321	HT29	viability after 7 days	GTGGAGGAAATTTTCCGCAAGG	CASP1	ENSG00000137752	0.8507457710240807	[161,126]	[467,414,146]	9	hSpCas9	negative selection	4803081
105026909	105026931	11	+	27760321	HT29	viability after 7 days	ATAAAAACAGAGCCCATTGTGG	CASP1	ENSG00000137752	0.10789783511699325	[126,98]	[122,195,145]	1	hSpCas9	negative selection	4803082
105026921	105026943	11	-	27760321	HT29	viability after 7 days	CTTGGAGACATCCCACAATGGG	CASP1	ENSG00000137752	-0.22168407212409091	[238,186]	[229,218,253]	-3	hSpCas9	negative selection	4803083
105029250	105029272	11	+	27760321	HT29	viability after 7 days	ACACCACACCAGGGCTGTCTGG	CASP1	ENSG00000137752	0.7386175131212559	[653,510]	[1318,1402,1041]	9	hSpCas9	negative selection	4803084
105029695	105029717	11	+	27760321	HT29	viability after 7 days	TCGGTTTGTCCTTCAAACTTGG	CASP1	ENSG00000137752	-0.08902640742069667	[252,197]	[293,268,257]	-1	hSpCas9	negative selection	4803085
105029802	105029824	11	-	27760321	HT29	viability after 7 days	TGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	-0.30444448612511027	[399,311]	[509,275,345]	-4	hSpCas9	negative selection	4803086
105029846	105029868	11	+	27760321	HT29	viability after 7 days	AGAGGTCTTGTGCTCTGGGCGG	CASP1	ENSG00000137752	0.25584359074016083	[712,556]	[1368,842,773]	4	hSpCas9	negative selection	4803087
105029881	105029903	11	-	27760321	HT29	viability after 7 days	CAGGACATGACTACAGAGCTGG	CASP1	ENSG00000137752	-0.24670351616626374	[352,275]	[334,402,284]	-4	hSpCas9	negative selection	4803088
105030368	105030390	11	-	27760321	HT29	viability after 7 days	ACAATGCTGCTACAAAATCTGG	CASP1	ENSG00000137752	0.6028555839197276	[283,221]	[610,578,313]	8	hSpCas9	negative selection	4803089
105030415	105030437	11	-	27760321	HT29	viability after 7 days	ACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.6009045862733857	[43,34]	[7,58,29]	-7	hSpCas9	negative selection	4803090
105030476	105030498	11	+	27760321	HT29	viability after 7 days	GGCTTGACTTGTCCATTATTGG	CASP1	ENSG00000137752	-0.4755647254051817	[254,198]	[367,107,176]	-6	hSpCas9	negative selection	4803091
105034286	105034308	11	-	27760321	HT29	viability after 7 days	GACTCCGTTATTCCGAAAGGGG	CASP1	ENSG00000137752	0.010865633370849004	[164,128]	[244,179,154]	0	hSpCas9	negative selection	4803092
105033114	105033136	11	-	27760321	HT29	viability after 7 days	TTTTCATAGATCAAACATCTGG	CASP1	ENSG00000137752	-0.9918959253850765	[23,18]	[26,15,0]	-8	hSpCas9	negative selection	4803093
105026841	105026863	11	-	27760321	HT29	viability after 25 days	GTGGAGGAAATTTTCCGCAAGG	CASP1	ENSG00000137752	1.0096810704529267	[161,126]	[229,412,363]	9	hSpCas9	negative selection	4886544
105026909	105026931	11	+	27760321	HT29	viability after 25 days	ATAAAAACAGAGCCCATTGTGG	CASP1	ENSG00000137752	0.2803301387712629	[126,98]	[130,156,186]	3	hSpCas9	negative selection	4886545
105026921	105026943	11	-	27760321	HT29	viability after 25 days	CTTGGAGACATCCCACAATGGG	CASP1	ENSG00000137752	0.2590677713655738	[238,186]	[268,219,396]	2	hSpCas9	negative selection	4886546
105029250	105029272	11	+	27760321	HT29	viability after 25 days	ACACCACACCAGGGCTGTCTGG	CASP1	ENSG00000137752	1.0837429409979213	[653,510]	[1374,1492,1359]	9	hSpCas9	negative selection	4886547
105029695	105029717	11	+	27760321	HT29	viability after 25 days	TCGGTTTGTCCTTCAAACTTGG	CASP1	ENSG00000137752	0.35766758996644465	[252,197]	[241,387,369]	4	hSpCas9	negative selection	4886548
105029802	105029824	11	-	27760321	HT29	viability after 25 days	TGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	-0.025098607038433245	[399,311]	[356,388,461]	0	hSpCas9	negative selection	4886549
105029846	105029868	11	+	27760321	HT29	viability after 25 days	AGAGGTCTTGTGCTCTGGGCGG	CASP1	ENSG00000137752	0.25678838679309957	[712,556]	[755,699,1183]	2	hSpCas9	negative selection	4886550
105029881	105029903	11	-	27760321	HT29	viability after 25 days	CAGGACATGACTACAGAGCTGG	CASP1	ENSG00000137752	0.3421311115375403	[352,275]	[583,371,395]	3	hSpCas9	negative selection	4886551
105030368	105030390	11	-	27760321	HT29	viability after 25 days	ACAATGCTGCTACAAAATCTGG	CASP1	ENSG00000137752	0.33788972871657175	[283,221]	[361,377,354]	3	hSpCas9	negative selection	4886552
105030415	105030437	11	-	27760321	HT29	viability after 25 days	ACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	0.3276962170110673	[43,34]	[59,51,57]	3	hSpCas9	negative selection	4886553
105030476	105030498	11	+	27760321	HT29	viability after 25 days	GGCTTGACTTGTCCATTATTGG	CASP1	ENSG00000137752	0.45392200356767565	[254,198]	[273,368,435]	5	hSpCas9	negative selection	4886554
105034286	105034308	11	-	27760321	HT29	viability after 25 days	GACTCCGTTATTCCGAAAGGGG	CASP1	ENSG00000137752	-0.19214141527315864	[164,128]	[238,41,154]	-2	hSpCas9	negative selection	4886555
105033114	105033136	11	-	27760321	HT29	viability after 25 days	TTTTCATAGATCAAACATCTGG	CASP1	ENSG00000137752	0.3884156097912177	[23,18]	[28,58,5]	4	hSpCas9	negative selection	4886556
105026841	105026863	11	-	27760321	HT29	viability after 22 days	GTGGAGGAAATTTTCCGCAAGG	CASP1	ENSG00000137752	0.740168656416865	[161,126]	[186,353,298]	8	hSpCas9	negative selection	4970007
105026909	105026931	11	+	27760321	HT29	viability after 22 days	ATAAAAACAGAGCCCATTGTGG	CASP1	ENSG00000137752	0.015868985028337113	[126,98]	[119,94,181]	0	hSpCas9	negative selection	4970008
105026921	105026943	11	-	27760321	HT29	viability after 22 days	CTTGGAGACATCCCACAATGGG	CASP1	ENSG00000137752	-0.47143965116416786	[238,186]	[156,138,237]	-4	hSpCas9	negative selection	4970009
105029250	105029272	11	+	27760321	HT29	viability after 22 days	ACACCACACCAGGGCTGTCTGG	CASP1	ENSG00000137752	1.0329439401135185	[653,510]	[1372,1391,1368]	9	hSpCas9	negative selection	4970010
105029695	105029717	11	+	27760321	HT29	viability after 22 days	TCGGTTTGTCCTTCAAACTTGG	CASP1	ENSG00000137752	0.8159329546754841	[252,197]	[468,419,487]	8	hSpCas9	negative selection	4970011
105029802	105029824	11	-	27760321	HT29	viability after 22 days	TGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	-0.2338137446256931	[399,311]	[308,390,350]	-2	hSpCas9	negative selection	4970012
105029846	105029868	11	+	27760321	HT29	viability after 22 days	AGAGGTCTTGTGCTCTGGGCGG	CASP1	ENSG00000137752	0.2077162707335396	[712,556]	[725,943,876]	2	hSpCas9	negative selection	4970013
105029881	105029903	11	-	27760321	HT29	viability after 22 days	CAGGACATGACTACAGAGCTGG	CASP1	ENSG00000137752	-0.0980539019245974	[352,275]	[267,423,328]	-1	hSpCas9	negative selection	4970014
105030368	105030390	11	-	27760321	HT29	viability after 22 days	ACAATGCTGCTACAAAATCTGG	CASP1	ENSG00000137752	0.7775040492827148	[283,221]	[485,372,646]	8	hSpCas9	negative selection	4970015
105030415	105030437	11	-	27760321	HT29	viability after 22 days	ACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	0.09833215407759655	[43,34]	[1,106,38]	1	hSpCas9	negative selection	4970016
105030476	105030498	11	+	27760321	HT29	viability after 22 days	GGCTTGACTTGTCCATTATTGG	CASP1	ENSG00000137752	0.25224079834601554	[254,198]	[196,408,334]	2	hSpCas9	negative selection	4970017
105034286	105034308	11	-	27760321	HT29	viability after 22 days	GACTCCGTTATTCCGAAAGGGG	CASP1	ENSG00000137752	-0.3110281401383641	[164,128]	[72,172,166]	-3	hSpCas9	negative selection	4970018
105033114	105033136	11	-	27760321	HT29	viability after 22 days	TTTTCATAGATCAAACATCTGG	CASP1	ENSG00000137752	0.4567606037020875	[23,18]	[1,97,2]	5	hSpCas9	negative selection	4970019
105026841	105026863	11	-	27760321	HT29	viability after 19 days	GTGGAGGAAATTTTCCGCAAGG	CASP1	ENSG00000137752	0.7885592691024801	[161,126]	[357,219,285]	7	hSpCas9	negative selection	5053470
105026909	105026931	11	+	27760321	HT29	viability after 19 days	ATAAAAACAGAGCCCATTGTGG	CASP1	ENSG00000137752	0.8875140377619477	[126,98]	[256,117,339]	8	hSpCas9	negative selection	5053471
105026921	105026943	11	-	27760321	HT29	viability after 19 days	CTTGGAGACATCCCACAATGGG	CASP1	ENSG00000137752	0.24034936676723828	[238,186]	[293,204,361]	2	hSpCas9	negative selection	5053472
105029250	105029272	11	+	27760321	HT29	viability after 19 days	ACACCACACCAGGGCTGTCTGG	CASP1	ENSG00000137752	1.1456522642457263	[653,510]	[1842,1391,1233]	9	hSpCas9	negative selection	5053473
105029695	105029717	11	+	27760321	HT29	viability after 19 days	TCGGTTTGTCCTTCAAACTTGG	CASP1	ENSG00000137752	0.9731163498370683	[252,197]	[258,543,682]	8	hSpCas9	negative selection	5053474
105029802	105029824	11	-	27760321	HT29	viability after 19 days	TGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	-0.6709066490687656	[399,311]	[210,152,392]	-5	hSpCas9	negative selection	5053475
105029846	105029868	11	+	27760321	HT29	viability after 19 days	AGAGGTCTTGTGCTCTGGGCGG	CASP1	ENSG00000137752	0.32848634575222735	[712,556]	[954,1064,726]	3	hSpCas9	negative selection	5053476
105029881	105029903	11	-	27760321	HT29	viability after 19 days	CAGGACATGACTACAGAGCTGG	CASP1	ENSG00000137752	0.18792869079608213	[352,275]	[281,505,426]	1	hSpCas9	negative selection	5053477
105030368	105030390	11	-	27760321	HT29	viability after 19 days	ACAATGCTGCTACAAAATCTGG	CASP1	ENSG00000137752	1.2152733849336275	[283,221]	[325,551,1084]	9	hSpCas9	negative selection	5053478
105030415	105030437	11	-	27760321	HT29	viability after 19 days	ACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-3.6184742419276663	[43,34]	[2,4,2]	-9	hSpCas9	negative selection	5053479
105030476	105030498	11	+	27760321	HT29	viability after 19 days	GGCTTGACTTGTCCATTATTGG	CASP1	ENSG00000137752	-0.17526955989253856	[254,198]	[173,420,93]	-2	hSpCas9	negative selection	5053480
105034286	105034308	11	-	27760321	HT29	viability after 19 days	GACTCCGTTATTCCGAAAGGGG	CASP1	ENSG00000137752	-0.18493795379413336	[164,128]	[106,67,259]	-2	hSpCas9	negative selection	5053481
105033114	105033136	11	-	27760321	HT29	viability after 19 days	TTTTCATAGATCAAACATCTGG	CASP1	ENSG00000137752	1.3422743900363625	[23,18]	[3,32,140]	9	hSpCas9	negative selection	5053482
105026841	105026863	11	-	27760321	HT29	viability after 16 days	GTGGAGGAAATTTTCCGCAAGG	CASP1	ENSG00000137752	0.4679082889739584	[161,126]	[189,329,144]	5	hSpCas9	negative selection	5136933
105026909	105026931	11	+	27760321	HT29	viability after 16 days	ATAAAAACAGAGCCCATTGTGG	CASP1	ENSG00000137752	0.8221412369069525	[126,98]	[405,97,186]	8	hSpCas9	negative selection	5136934
105026921	105026943	11	-	27760321	HT29	viability after 16 days	CTTGGAGACATCCCACAATGGG	CASP1	ENSG00000137752	0.508157970642286	[238,186]	[277,266,467]	6	hSpCas9	negative selection	5136935
105029250	105029272	11	+	27760321	HT29	viability after 16 days	ACACCACACCAGGGCTGTCTGG	CASP1	ENSG00000137752	0.7759337169832482	[653,510]	[1543,932,915]	8	hSpCas9	negative selection	5136936
105029695	105029717	11	+	27760321	HT29	viability after 16 days	TCGGTTTGTCCTTCAAACTTGG	CASP1	ENSG00000137752	0.2656240116622466	[252,197]	[337,159,418]	3	hSpCas9	negative selection	5136937
105029802	105029824	11	-	27760321	HT29	viability after 16 days	TGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	-0.4938032251394701	[399,311]	[307,276,265]	-5	hSpCas9	negative selection	5136938
105029846	105029868	11	+	27760321	HT29	viability after 16 days	AGAGGTCTTGTGCTCTGGGCGG	CASP1	ENSG00000137752	-0.009564630758204018	[712,556]	[602,534,973]	0	hSpCas9	negative selection	5136939
105029881	105029903	11	-	27760321	HT29	viability after 16 days	CAGGACATGACTACAGAGCTGG	CASP1	ENSG00000137752	0.23467323082647612	[352,275]	[276,573,373]	2	hSpCas9	negative selection	5136940
105030368	105030390	11	-	27760321	HT29	viability after 16 days	ACAATGCTGCTACAAAATCTGG	CASP1	ENSG00000137752	0.31759893710358345	[283,221]	[399,114,553]	3	hSpCas9	negative selection	5136941
105030415	105030437	11	-	27760321	HT29	viability after 16 days	ACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	0.7122228539922641	[43,34]	[71,87,56]	8	hSpCas9	negative selection	5136942
105030476	105030498	11	+	27760321	HT29	viability after 16 days	GGCTTGACTTGTCCATTATTGG	CASP1	ENSG00000137752	0.13416272704965837	[254,198]	[201,349,274]	1	hSpCas9	negative selection	5136943
105034286	105034308	11	-	27760321	HT29	viability after 16 days	GACTCCGTTATTCCGAAAGGGG	CASP1	ENSG00000137752	0.008402144951955792	[164,128]	[291,136,79]	0	hSpCas9	negative selection	5136944
105033114	105033136	11	-	27760321	HT29	viability after 16 days	TTTTCATAGATCAAACATCTGG	CASP1	ENSG00000137752	0.9096728447109208	[23,18]	[16,83,30]	9	hSpCas9	negative selection	5136945
105026841	105026863	11	-	27760321	HT29	viability after 13 days	GTGGAGGAAATTTTCCGCAAGG	CASP1	ENSG00000137752	0.6282394442858822	[161,126]	[286,257,233]	7	hSpCas9	negative selection	5220396
105026909	105026931	11	+	27760321	HT29	viability after 13 days	ATAAAAACAGAGCCCATTGTGG	CASP1	ENSG00000137752	0.2216516427980164	[126,98]	[189,39,223]	2	hSpCas9	negative selection	5220397
105026921	105026943	11	-	27760321	HT29	viability after 13 days	CTTGGAGACATCCCACAATGGG	CASP1	ENSG00000137752	0.2232350260935655	[238,186]	[253,279,328]	2	hSpCas9	negative selection	5220398
105029250	105029272	11	+	27760321	HT29	viability after 13 days	ACACCACACCAGGGCTGTCTGG	CASP1	ENSG00000137752	0.7689176467738551	[653,510]	[1305,1300,864]	8	hSpCas9	negative selection	5220399
105029695	105029717	11	+	27760321	HT29	viability after 13 days	TCGGTTTGTCCTTCAAACTTGG	CASP1	ENSG00000137752	0.7836951623337964	[252,197]	[499,466,387]	8	hSpCas9	negative selection	5220400
105029802	105029824	11	-	27760321	HT29	viability after 13 days	TGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	-0.17611122793840214	[399,311]	[487,238,368]	-2	hSpCas9	negative selection	5220401
105029846	105029868	11	+	27760321	HT29	viability after 13 days	AGAGGTCTTGTGCTCTGGGCGG	CASP1	ENSG00000137752	-0.03526115276520159	[712,556]	[662,829,666]	0	hSpCas9	negative selection	5220402
105029881	105029903	11	-	27760321	HT29	viability after 13 days	CAGGACATGACTACAGAGCTGG	CASP1	ENSG00000137752	-0.0924370742662306	[352,275]	[287,450,290]	-1	hSpCas9	negative selection	5220403
105030368	105030390	11	-	27760321	HT29	viability after 13 days	ACAATGCTGCTACAAAATCTGG	CASP1	ENSG00000137752	0.5018743616119006	[283,221]	[362,518,367]	6	hSpCas9	negative selection	5220404
105030415	105030437	11	-	27760321	HT29	viability after 13 days	ACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.358934595366212	[43,34]	[28,53,24]	-4	hSpCas9	negative selection	5220405
105030476	105030498	11	+	27760321	HT29	viability after 13 days	GGCTTGACTTGTCCATTATTGG	CASP1	ENSG00000137752	-0.3530530924960079	[254,198]	[161,137,311]	-4	hSpCas9	negative selection	5220406
105034286	105034308	11	-	27760321	HT29	viability after 13 days	GACTCCGTTATTCCGAAAGGGG	CASP1	ENSG00000137752	-0.4943781509152714	[164,128]	[145,161,58]	-5	hSpCas9	negative selection	5220407
105033114	105033136	11	-	27760321	HT29	viability after 13 days	TTTTCATAGATCAAACATCTGG	CASP1	ENSG00000137752	0.2555578875731981	[23,18]	[33,52,3]	3	hSpCas9	negative selection	5220408
105026841	105026863	11	-	27760321	HT29	viability after 10 days	GTGGAGGAAATTTTCCGCAAGG	CASP1	ENSG00000137752	0.7334250015405602	[161,126]	[346,437,122]	8	hSpCas9	negative selection	5303859
105026909	105026931	11	+	27760321	HT29	viability after 10 days	ATAAAAACAGAGCCCATTGTGG	CASP1	ENSG00000137752	0.13709171632936235	[126,98]	[121,121,218]	1	hSpCas9	negative selection	5303860
105026921	105026943	11	-	27760321	HT29	viability after 10 days	CTTGGAGACATCCCACAATGGG	CASP1	ENSG00000137752	0.6391090479339272	[238,186]	[322,281,628]	8	hSpCas9	negative selection	5303861
105029250	105029272	11	+	27760321	HT29	viability after 10 days	ACACCACACCAGGGCTGTCTGG	CASP1	ENSG00000137752	0.7693070526456015	[653,510]	[960,1285,1467]	9	hSpCas9	negative selection	5303862
105029695	105029717	11	+	27760321	HT29	viability after 10 days	TCGGTTTGTCCTTCAAACTTGG	CASP1	ENSG00000137752	0.46663247760461624	[252,197]	[418,348,397]	6	hSpCas9	negative selection	5303863
105029802	105029824	11	-	27760321	HT29	viability after 10 days	TGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	-0.7399101663089085	[399,311]	[421,188,186]	-7	hSpCas9	negative selection	5303864
105029846	105029868	11	+	27760321	HT29	viability after 10 days	AGAGGTCTTGTGCTCTGGGCGG	CASP1	ENSG00000137752	-0.15050073111889717	[712,556]	[598,667,870]	-2	hSpCas9	negative selection	5303865
105029881	105029903	11	-	27760321	HT29	viability after 10 days	CAGGACATGACTACAGAGCTGG	CASP1	ENSG00000137752	-0.16971470486791196	[352,275]	[354,419,275]	-2	hSpCas9	negative selection	5303866
105030368	105030390	11	-	27760321	HT29	viability after 10 days	ACAATGCTGCTACAAAATCTGG	CASP1	ENSG00000137752	0.2726564238796729	[283,221]	[411,270,456]	3	hSpCas9	negative selection	5303867
105030415	105030437	11	-	27760321	HT29	viability after 10 days	ACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.05850135399171075	[43,34]	[1,42,95]	-1	hSpCas9	negative selection	5303868
105030476	105030498	11	+	27760321	HT29	viability after 10 days	GGCTTGACTTGTCCATTATTGG	CASP1	ENSG00000137752	0.5046965941934585	[254,198]	[354,376,471]	7	hSpCas9	negative selection	5303869
105034286	105034308	11	-	27760321	HT29	viability after 10 days	GACTCCGTTATTCCGAAAGGGG	CASP1	ENSG00000137752	0.10367790452207815	[164,128]	[138,269,184]	1	hSpCas9	negative selection	5303870
105033114	105033136	11	-	27760321	HT29	viability after 10 days	TTTTCATAGATCAAACATCTGG	CASP1	ENSG00000137752	-0.4179597558112427	[23,18]	[16,34,8]	-5	hSpCas9	negative selection	5303871
105026841	105026863	11	-	27760321	MOLM13	viability	GTGGAGGAAATTTTCCGCAAGG	CASP1	ENSG00000137752	2.110937061849147	[189,161]	[399,450]	9	hSpCas9	negative selection	5387322
105026909	105026931	11	+	27760321	MOLM13	viability	ATAAAAACAGAGCCCATTGTGG	CASP1	ENSG00000137752	-0.8883733672509146	[150,126]	[25,55]	-5	hSpCas9	negative selection	5387323
105026921	105026943	11	-	27760321	MOLM13	viability	CTTGGAGACATCCCACAATGGG	CASP1	ENSG00000137752	-2.987644679222144	[292,238]	[0,33]	-9	hSpCas9	negative selection	5387324
105029250	105029272	11	+	27760321	MOLM13	viability	ACACCACACCAGGGCTGTCTGG	CASP1	ENSG00000137752	1.788231917775679	[873,653]	[2671,457]	9	hSpCas9	negative selection	5387325
105029695	105029717	11	+	27760321	MOLM13	viability	TCGGTTTGTCCTTCAAACTTGG	CASP1	ENSG00000137752	0.3650447555703953	[285,252]	[235,160]	2	hSpCas9	negative selection	5387326
105029802	105029824	11	-	27760321	MOLM13	viability	TGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	0.1991902670742418	[410,399]	[118,385]	1	hSpCas9	negative selection	5387327
105029846	105029868	11	+	27760321	MOLM13	viability	AGAGGTCTTGTGCTCTGGGCGG	CASP1	ENSG00000137752	0.1324272197782358	[795,712]	[821,162]	0	hSpCas9	negative selection	5387328
105029881	105029903	11	-	27760321	MOLM13	viability	CAGGACATGACTACAGAGCTGG	CASP1	ENSG00000137752	-2.4171845434759853	[457,352]	[48,36]	-8	hSpCas9	negative selection	5387329
105030368	105030390	11	-	27760321	MOLM13	viability	ACAATGCTGCTACAAAATCTGG	CASP1	ENSG00000137752	0.9237068547958505	[327,283]	[512,167]	6	hSpCas9	negative selection	5387330
105030415	105030437	11	-	27760321	MOLM13	viability	ACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-4.682892683445683	[46,43]	[0,0]	-9	hSpCas9	negative selection	5387331
105030476	105030498	11	+	27760321	MOLM13	viability	GGCTTGACTTGTCCATTATTGG	CASP1	ENSG00000137752	1.5128321556763542	[259,254]	[292,519]	9	hSpCas9	negative selection	5387332
105034286	105034308	11	-	27760321	MOLM13	viability	GACTCCGTTATTCCGAAAGGGG	CASP1	ENSG00000137752	-0.6201175990253596	[176,164]	[78,48]	-4	hSpCas9	negative selection	5387333
105033114	105033136	11	-	27760321	MOLM13	viability	TTTTCATAGATCAAACATCTGG	CASP1	ENSG00000137752	0.9589255121758451	[39,23]	[0,62]	6	hSpCas9	negative selection	5387334
105034729	105034752	11	+	27661255	K562	viability	GTCGCATGTTTATTTAACTCTGG	CASP1	ENSG00000137752	0.0058395296779283346	[951,889]	[785,699]	0	dCas9-KRAB	negative selection	5468187
105034933	105034956	11	-	27661255	K562	viability	GATTCTTGCAGACTTTAGAAAGG	CASP1	ENSG00000137752	0.014801743973380632	[1003,1205]	[1005,788]	0	dCas9-KRAB	negative selection	5468188
105035046	105035069	11	-	27661255	K562	viability	GAAAGAGTTTTGGAAGGGGCTGG	CASP1	ENSG00000137752	0.054882857088842614	[668,753]	[661,526]	1	dCas9-KRAB	negative selection	5468189
105035050	105035073	11	-	27661255	K562	viability	GGAAGAAAGAGTTTTGGAAGGGG	CASP1	ENSG00000137752	-0.12931674782086036	[713,800]	[557,546]	-4	dCas9-KRAB	negative selection	5468190
105030415	105030438	11	-	27260156	BXPC3	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.7184844973168396	[296]	[162,132,179,296]	-8	hSpCas9	negative selection	5533455
105030455	105030478	11	+	27260156	BXPC3	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.019812560129813583	[1348]	[1049,1327,1596,1835]	0	hSpCas9	negative selection	5533456
105031189	105031212	11	-	27260156	BXPC3	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.17359369791376533	[1100]	[1127,1204,1446,1449]	4	hSpCas9	negative selection	5533457
105034430	105034453	11	-	27260156	BXPC3	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.18809437648620264	[133]	[109,161,224,144]	4	hSpCas9	negative selection	5597733
105031164	105031187	11	-	27260156	BXPC3	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.09659874653333628	[371]	[353,235,392,494]	-2	hSpCas9	negative selection	5597734
105033085	105033108	11	+	27260156	BXPC3	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.2613859100520462	[627]	[601,767,796,1026]	6	hSpCas9	negative selection	5597735
105030415	105030438	11	-	27260156	A673	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.7305372864409609	[296]	[192,192,152,324]	-9	hSpCas9	negative selection	5654706
105030455	105030478	11	+	27260156	A673	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.07022279360634931	[1348]	[1701,1734,1507,1863]	1	hSpCas9	negative selection	5654707
105031189	105031212	11	-	27260156	A673	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.17284039564360087	[1100]	[1609,1381,1414,1572]	4	hSpCas9	negative selection	5654708
105034430	105034453	11	-	27260156	A673	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.13207172900369168	[133]	[130,122,161,170]	-3	hSpCas9	negative selection	5718984
105031164	105031187	11	-	27260156	A673	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.006189277652013436	[371]	[549,495,390,346]	0	hSpCas9	negative selection	5718985
105033085	105033108	11	+	27260156	A673	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.15373741699391014	[627]	[886,715,784,982]	3	hSpCas9	negative selection	5718986
105030415	105030438	11	-	27260156	A375	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.9392518185266963	[296]	[259,152,156,152]	-8	hSpCas9	negative selection	5775957
105030455	105030478	11	+	27260156	A375	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.06422787273936859	[1348]	[1506,2227,1495,1454]	0	hSpCas9	negative selection	5775958
105031189	105031212	11	-	27260156	A375	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.18597316568682642	[1100]	[1492,1871,1352,1214]	2	hSpCas9	negative selection	5775959
105034430	105034453	11	-	27260156	A375	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.4294204229472527	[133]	[154,118,110,83]	-5	hSpCas9	negative selection	5840235
105031164	105031187	11	-	27260156	A375	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.14854618696715172	[371]	[273,394,449,440]	-2	hSpCas9	negative selection	5840236
105033085	105033108	11	+	27260156	A375	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.8509874491913085	[627]	[1071,1975,1328,1033]	9	hSpCas9	negative selection	5840237
105030415	105030438	11	-	27260156	COLO741	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.8136792046406245	[296]	[219,217,209]	-9	hSpCas9	negative selection	5897208
105030455	105030478	11	+	27260156	COLO741	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.02560648644691277	[1348]	[1776,1681,1628]	0	hSpCas9	negative selection	5897209
105031189	105031212	11	-	27260156	COLO741	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.13802291508554543	[1100]	[1813,1446,1411]	3	hSpCas9	negative selection	5897210
105034430	105034453	11	-	27260156	COLO741	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.002560259628525463	[133]	[180,190,144]	0	hSpCas9	negative selection	5961486
105031164	105031187	11	-	27260156	COLO741	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.009468999483060514	[371]	[558,506,364]	0	hSpCas9	negative selection	5961487
105033085	105033108	11	+	27260156	COLO741	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.25033482846118876	[627]	[950,942,965]	5	hSpCas9	negative selection	5961488
105030415	105030438	11	-	27260156	CAL120	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.3804061699474188	[296]	[202,437,199]	-5	hSpCas9	negative selection	6018459
105030455	105030478	11	+	27260156	CAL120	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.15392369383982318	[1348]	[1757,1560,1248]	-2	hSpCas9	negative selection	6018460
105031189	105031212	11	-	27260156	CAL120	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.22426265757218755	[1100]	[1702,1611,1502]	3	hSpCas9	negative selection	6018461
105034430	105034453	11	-	27260156	CAL120	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.7124141839644351	[133]	[84,74,141]	-7	hSpCas9	negative selection	6082737
105031164	105031187	11	-	27260156	CAL120	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.6020909704176564	[371]	[265,398,244]	-7	hSpCas9	negative selection	6082738
105033085	105033108	11	+	27260156	CAL120	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.598714710649654	[627]	[1061,1254,1213]	8	hSpCas9	negative selection	6082739
105030415	105030438	11	-	27260156	CADOES1	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.4660145466118297	[296]	[214,170,208,204]	-7	hSpCas9	negative selection	6139710
105030455	105030478	11	+	27260156	CADOES1	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.04012537992178178	[1348]	[1488,1205,1313,1144]	0	hSpCas9	negative selection	6139711
105031189	105031212	11	-	27260156	CADOES1	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.259084115745998	[1100]	[1100,1182,1364,1253]	4	hSpCas9	negative selection	6139712
105034430	105034453	11	-	27260156	CADOES1	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.49544947602546685	[133]	[88,74,115,72]	-7	hSpCas9	negative selection	6203988
105031164	105031187	11	-	27260156	CADOES1	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.01641405256743944	[371]	[228,338,318,486]	0	hSpCas9	negative selection	6203989
105033085	105033108	11	+	27260156	CADOES1	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.520776277312683	[627]	[715,819,855,964]	8	hSpCas9	negative selection	6203990
105030415	105030438	11	-	27260156	EWS502	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.6350097435831996	[296]	[153,114,300,253]	-7	hSpCas9	negative selection	6260961
105030455	105030478	11	+	27260156	EWS502	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.09764454500305675	[1348]	[1203,1151,1338,1689]	-2	hSpCas9	negative selection	6260962
105031189	105031212	11	-	27260156	EWS502	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.239506601350562	[1100]	[1264,1315,1357,1593]	4	hSpCas9	negative selection	6260963
105034430	105034453	11	-	27260156	EWS502	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.26204691422151605	[133]	[220,176,84,190]	4	hSpCas9	negative selection	6325239
105031164	105031187	11	-	27260156	EWS502	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.013948172955745852	[371]	[410,366,376,436]	0	hSpCas9	negative selection	6325240
105033085	105033108	11	+	27260156	EWS502	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.2497234861751056	[627]	[601,790,925,871]	4	hSpCas9	negative selection	6325241
105030415	105030438	11	-	27260156	EW8	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.9464294070943713	[296]	[157,130,136,74]	-9	hSpCas9	negative selection	6382212
105030455	105030478	11	+	27260156	EW8	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.09563032667032512	[1348]	[1286,1343,739,797]	-2	hSpCas9	negative selection	6382213
105031189	105031212	11	-	27260156	EW8	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.12301019480088571	[1100]	[970,980,970,960]	2	hSpCas9	negative selection	6382214
105034430	105034453	11	-	27260156	EW8	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.39909516235586695	[133]	[129,172,131,137]	7	hSpCas9	negative selection	6446490
105031164	105031187	11	-	27260156	EW8	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.24589396719026987	[371]	[415,426,225,388]	4	hSpCas9	negative selection	6446491
105033085	105033108	11	+	27260156	EW8	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.4334587659527082	[627]	[768,579,546,882]	7	hSpCas9	negative selection	6446492
105030415	105030438	11	-	27260156	CORL105	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.342554867312606	[296]	[228,177,464,254]	-6	hSpCas9	negative selection	6503463
105030455	105030478	11	+	27260156	CORL105	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.14673108073484298	[1348]	[1715,1781,1873,1638]	2	hSpCas9	negative selection	6503464
105031189	105031212	11	-	27260156	CORL105	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.33288411897783887	[1100]	[1678,1370,1965,1537]	6	hSpCas9	negative selection	6503465
105034430	105034453	11	-	27260156	CORL105	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.5617879726601509	[133]	[94,86,187,67]	-7	hSpCas9	negative selection	6567741
105031164	105031187	11	-	27260156	CORL105	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.12789211336699996	[371]	[375,404,547,287]	-2	hSpCas9	negative selection	6567742
105033085	105033108	11	+	27260156	CORL105	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.31222357723205446	[627]	[808,881,1234,772]	6	hSpCas9	negative selection	6567743
105030415	105030438	11	-	27260156	HS294T	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.8126666285779549	[296]	[96,30,52,80]	-8	hSpCas9	negative selection	6624714
105030455	105030478	11	+	27260156	HS294T	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.07845481809567012	[1348]	[729,394,398,417]	-1	hSpCas9	negative selection	6624715
105031189	105031212	11	-	27260156	HS294T	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.2106060980315949	[1100]	[377,628,401,580]	3	hSpCas9	negative selection	6624716
105034430	105034453	11	-	27260156	HS294T	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.25457518350256514	[133]	[34,47,43,47]	-4	hSpCas9	negative selection	6688992
105031164	105031187	11	-	27260156	HS294T	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.5201331332710395	[371]	[165,247,195,218]	7	hSpCas9	negative selection	6688993
105033085	105033108	11	+	27260156	HS294T	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.7725000321410058	[627]	[515,358,413,349]	8	hSpCas9	negative selection	6688994
105030415	105030438	11	-	27260156	HCC44	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-1.2104138807176235	[296]	[173,50,275,117]	-9	hSpCas9	negative selection	6745965
105030455	105030478	11	+	27260156	HCC44	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.07640079524031251	[1348]	[1518,1342,2179,1510]	1	hSpCas9	negative selection	6745966
105031189	105031212	11	-	27260156	HCC44	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.27786206504698896	[1100]	[1388,1499,1859,1333]	4	hSpCas9	negative selection	6745967
105034430	105034453	11	-	27260156	HCC44	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.29259751356186436	[133]	[237,145,217,155]	5	hSpCas9	negative selection	6810243
105031164	105031187	11	-	27260156	HCC44	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.18669036506503262	[371]	[604,545,399,352]	3	hSpCas9	negative selection	6810244
105033085	105033108	11	+	27260156	HCC44	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.6317554913735899	[627]	[1290,932,1536,759]	9	hSpCas9	negative selection	6810245
105030415	105030438	11	-	27260156	G402	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	0.003229720428223559	[296]	[166,343,314,584]	0	hSpCas9	negative selection	6867216
105030455	105030478	11	+	27260156	G402	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.1520931584354428	[1348]	[1834,2091,1944,1470]	2	hSpCas9	negative selection	6867217
105031189	105031212	11	-	27260156	G402	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.5387884546089463	[1100]	[2021,1838,2206,1744]	6	hSpCas9	negative selection	6867218
105034430	105034453	11	-	27260156	G402	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.35083610785457875	[133]	[153,334,14,28]	-4	hSpCas9	negative selection	6931494
105031164	105031187	11	-	27260156	G402	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.43236237966300883	[371]	[274,209,379,456]	-5	hSpCas9	negative selection	6931495
105033085	105033108	11	+	27260156	G402	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.8575348761798367	[627]	[1315,2101,1186,993]	9	hSpCas9	negative selection	6931496
105030415	105030438	11	-	27260156	L33	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.728251243826646	[296]	[243,50,88,204]	-9	hSpCas9	negative selection	6988467
105030455	105030478	11	+	27260156	L33	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.1652360212265067	[1348]	[1199,506,713,1237]	-4	hSpCas9	negative selection	6988468
105031189	105031212	11	-	27260156	L33	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.11045617462901136	[1100]	[1146,431,751,1355]	2	hSpCas9	negative selection	6988469
105034430	105034453	11	-	27260156	L33	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.00639116567568454	[133]	[189,41,62,143]	0	hSpCas9	negative selection	7052745
105031164	105031187	11	-	27260156	L33	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.29375040900346805	[371]	[251,119,267,244]	-6	hSpCas9	negative selection	7052746
105033085	105033108	11	+	27260156	L33	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.1881652879467191	[627]	[729,317,386,738]	4	hSpCas9	negative selection	7052747
105030415	105030438	11	-	27260156	K562	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.06864564182259447	[296]	[416,106,251,235]	-1	hSpCas9	negative selection	7109718
105030455	105030478	11	+	27260156	K562	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.28644054297739063	[1348]	[1193,1625,1116,1838]	3	hSpCas9	negative selection	7109719
105031189	105031212	11	-	27260156	K562	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.2988281289722594	[1100]	[1284,873,948,1632]	4	hSpCas9	negative selection	7109720
105034430	105034453	11	-	27260156	K562	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.12198181187779533	[133]	[141,151,111,114]	1	hSpCas9	negative selection	7173996
105031164	105031187	11	-	27260156	K562	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.335745784314198	[371]	[210,933,310,239]	4	hSpCas9	negative selection	7173997
105033085	105033108	11	+	27260156	K562	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.5191338168506283	[627]	[1123,1116,424,592]	6	hSpCas9	negative selection	7173998
105030415	105030438	11	-	27260156	HT29	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-1.3323636030861545	[296]	[98,194,104,170]	-9	hSpCas9	negative selection	7230969
105030455	105030478	11	+	27260156	HT29	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.04463660654025725	[1348]	[1685,1926,1665,1515]	0	hSpCas9	negative selection	7230970
105031189	105031212	11	-	27260156	HT29	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.2583637094859832	[1100]	[1773,1745,1524,1397]	5	hSpCas9	negative selection	7230971
105034430	105034453	11	-	27260156	HT29	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.1784118328588642	[133]	[155,108,229,226]	3	hSpCas9	negative selection	7295247
105031164	105031187	11	-	27260156	HT29	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.11006012826686229	[371]	[408,412,561,544]	2	hSpCas9	negative selection	7295248
105033085	105033108	11	+	27260156	HT29	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.3899404683051442	[627]	[1222,958,972,868]	7	hSpCas9	negative selection	7295249
105030415	105030438	11	-	27260156	MHHES1	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.9257738890556702	[296]	[209,195,209,106]	-9	hSpCas9	negative selection	7352220
105030455	105030478	11	+	27260156	MHHES1	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.2399486998672251	[1348]	[1774,1161,1461,864]	-4	hSpCas9	negative selection	7352221
105031189	105031212	11	-	27260156	MHHES1	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.06112154051992702	[1100]	[1247,1784,955,1215]	1	hSpCas9	negative selection	7352222
105034430	105034453	11	-	27260156	MHHES1	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.5135758383490483	[133]	[188,79,115,54]	-7	hSpCas9	negative selection	7416498
105031164	105031187	11	-	27260156	MHHES1	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.5061048925553243	[371]	[277,348,348,218]	-7	hSpCas9	negative selection	7416499
105033085	105033108	11	+	27260156	MHHES1	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.6092255159163096	[627]	[1108,1285,1195,792]	9	hSpCas9	negative selection	7416500
105030415	105030438	11	-	27260156	MEWO	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.9196507659774835	[296]	[184,149,112]	-9	hSpCas9	negative selection	7473471
105030455	105030478	11	+	27260156	MEWO	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.19299352477956377	[1348]	[1229,959,1146]	-4	hSpCas9	negative selection	7473472
105031189	105031212	11	-	27260156	MEWO	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.16158332899465377	[1100]	[1246,1051,1175]	3	hSpCas9	negative selection	7473473
105034430	105034453	11	-	27260156	MEWO	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.08393769708006027	[133]	[242,118,57]	1	hSpCas9	negative selection	7537749
105031164	105031187	11	-	27260156	MEWO	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.01588540305688635	[371]	[369,367,320]	0	hSpCas9	negative selection	7537750
105033085	105033108	11	+	27260156	MEWO	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.2838841514957398	[627]	[787,680,690]	6	hSpCas9	negative selection	7537751
105030415	105030438	11	-	27260156	LNCAPCLONEFGC	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.8472780739242574	[296]	[113,99,209,186]	-8	hSpCas9	negative selection	7594722
105030455	105030478	11	+	27260156	LNCAPCLONEFGC	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.0014236956584465776	[1348]	[1113,1121,1456,1232]	0	hSpCas9	negative selection	7594723
105031189	105031212	11	-	27260156	LNCAPCLONEFGC	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.2610187548483853	[1100]	[1178,1059,1376,1199]	4	hSpCas9	negative selection	7594724
105034430	105034453	11	-	27260156	LNCAPCLONEFGC	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.1031704465925487	[133]	[265,61,80,106]	1	hSpCas9	negative selection	7659000
105031164	105031187	11	-	27260156	LNCAPCLONEFGC	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.4209850341229622	[371]	[264,256,244,237]	-6	hSpCas9	negative selection	7659001
105033085	105033108	11	+	27260156	LNCAPCLONEFGC	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.31322056801606996	[627]	[457,846,818,714]	5	hSpCas9	negative selection	7659002
105030415	105030438	11	-	27260156	PANC0327	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.800007829038847	[296]	[136,188,126,146]	-8	hSpCas9	negative selection	7715973
105030455	105030478	11	+	27260156	PANC0327	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.34419683536869394	[1348]	[2008,1402,1162,1563]	5	hSpCas9	negative selection	7715974
105031189	105031212	11	-	27260156	PANC0327	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.23974080916605334	[1100]	[1457,956,973,1279]	3	hSpCas9	negative selection	7715975
105034430	105034453	11	-	27260156	PANC0327	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.23256696111885655	[133]	[121,53,172,219]	3	hSpCas9	negative selection	7780251
105031164	105031187	11	-	27260156	PANC0327	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.1623073221948338	[371]	[386,318,358,421]	2	hSpCas9	negative selection	7780252
105033085	105033108	11	+	27260156	PANC0327	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.5850789946652903	[627]	[822,752,929,850]	8	hSpCas9	negative selection	7780253
105030415	105030438	11	-	27260156	NCIH2009	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.21437827407333943	[296]	[515,283,304]	-3	hSpCas9	negative selection	7837224
105030455	105030478	11	+	27260156	NCIH2009	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.18883219417312813	[1348]	[2081,1995,2352]	2	hSpCas9	negative selection	7837225
105031189	105031212	11	-	27260156	NCIH2009	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.11011076728165148	[1100]	[2060,1395,1604]	1	hSpCas9	negative selection	7837226
105034430	105034453	11	-	27260156	NCIH2009	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.015571083537244457	[133]	[271,210,88]	0	hSpCas9	negative selection	7901502
105031164	105031187	11	-	27260156	NCIH2009	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.2252280806545055	[371]	[470,461,404]	-3	hSpCas9	negative selection	7901503
105033085	105033108	11	+	27260156	NCIH2009	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.5135317844717737	[627]	[1385,1080,1317]	7	hSpCas9	negative selection	7901504
105030415	105030438	11	-	27260156	NCIH1373	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	0.1858969935920668	[296]	[482,255,400,105]	1	hSpCas9	negative selection	7958475
105030455	105030478	11	+	27260156	NCIH1373	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.2547218498178865	[1348]	[1351,930,1359,388]	-3	hSpCas9	negative selection	7958476
105031189	105031212	11	-	27260156	NCIH1373	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.18944619546794383	[1100]	[2023,1507,1262,231]	1	hSpCas9	negative selection	7958477
105034430	105034453	11	-	27260156	NCIH1373	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.08521767175261585	[133]	[205,180,104,19]	-1	hSpCas9	negative selection	8022753
105031164	105031187	11	-	27260156	NCIH1373	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.157807465793266	[371]	[201,201,665,107]	-1	hSpCas9	negative selection	8022754
105033085	105033108	11	+	27260156	NCIH1373	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.9600080537770197	[627]	[2203,1352,692,358]	8	hSpCas9	negative selection	8022755
105030415	105030438	11	-	27260156	PATU8902	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.06320818219260671	[296]	[272,477,575,182]	0	hSpCas9	negative selection	8079726
105030455	105030478	11	+	27260156	PATU8902	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.20522443054759054	[1348]	[1994,1668,1446,1410]	-2	hSpCas9	negative selection	8079727
105031189	105031212	11	-	27260156	PATU8902	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	-0.018744267235653034	[1100]	[1621,1651,1120,1779]	0	hSpCas9	negative selection	8079728
105034430	105034453	11	-	27260156	PATU8902	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.6412919223779492	[133]	[244,342,148,485]	6	hSpCas9	negative selection	8144004
105031164	105031187	11	-	27260156	PATU8902	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.5155316960218391	[371]	[240,175,186,960]	-5	hSpCas9	negative selection	8144005
105033085	105033108	11	+	27260156	PATU8902	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.9420127713135984	[627]	[1821,1767,1737,1319]	8	hSpCas9	negative selection	8144006
105030415	105030438	11	-	27260156	PANC1	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.6255327337958931	[296]	[173,243,123,136]	-7	hSpCas9	negative selection	8200977
105030455	105030478	11	+	27260156	PANC1	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.24787570311869778	[1348]	[1244,1638,1445,1231]	4	hSpCas9	negative selection	8200978
105031189	105031212	11	-	27260156	PANC1	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.5380488930044185	[1100]	[1151,1568,1395,1393]	8	hSpCas9	negative selection	8200979
105034430	105034453	11	-	27260156	PANC1	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.32098008871733885	[133]	[73,198,196,119]	5	hSpCas9	negative selection	8265255
105031164	105031187	11	-	27260156	PANC1	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.19417395029532086	[371]	[412,500,317,266]	3	hSpCas9	negative selection	8265256
105033085	105033108	11	+	27260156	PANC1	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.47895026583989536	[627]	[714,919,880,548]	7	hSpCas9	negative selection	8265257
105030415	105030438	11	-	27260156	PANC0813	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.2036021018084685	[296]	[166,208,454,364]	-3	hSpCas9	negative selection	8322228
105030455	105030478	11	+	27260156	PANC0813	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.11743519640211719	[1348]	[1346,1695,1597,1203]	-2	hSpCas9	negative selection	8322229
105031189	105031212	11	-	27260156	PANC0813	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.303401888810497	[1100]	[1918,1411,1557,1525]	5	hSpCas9	negative selection	8322230
105034430	105034453	11	-	27260156	PANC0813	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.1761006304572994	[133]	[123,138,175,117]	-3	hSpCas9	negative selection	8386506
105031164	105031187	11	-	27260156	PANC0813	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.11573792908640351	[371]	[391,341,357,512]	-2	hSpCas9	negative selection	8386507
105033085	105033108	11	+	27260156	PANC0813	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.5124155190550204	[627]	[1084,971,988,1157]	7	hSpCas9	negative selection	8386508
105030415	105030438	11	-	27260156	RDES	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.9245584150495691	[296]	[105,185,221,224]	-9	hSpCas9	negative selection	8443479
105030455	105030478	11	+	27260156	RDES	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.08865636348575112	[1348]	[1062,1400,1496,2009]	-1	hSpCas9	negative selection	8443480
105031189	105031212	11	-	27260156	RDES	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	-0.04804326184512675	[1100]	[778,1180,1376,1709]	-1	hSpCas9	negative selection	8443481
105034430	105034453	11	-	27260156	RDES	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.2483320553221442	[133]	[149,109,108,143]	-4	hSpCas9	negative selection	8507757
105031164	105031187	11	-	27260156	RDES	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.5037734307697664	[371]	[306,204,332,371]	-7	hSpCas9	negative selection	8507758
105033085	105033108	11	+	27260156	RDES	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.5037848576177097	[627]	[753,917,1082,1447]	7	hSpCas9	negative selection	8507759
105030415	105030438	11	-	27260156	PC3	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-1.2203617061852652	[296]	[82,112,191,153]	-9	hSpCas9	negative selection	8564730
105030455	105030478	11	+	27260156	PC3	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.07703252832819718	[1348]	[871,1482,1982,1054]	-2	hSpCas9	negative selection	8564731
105031189	105031212	11	-	27260156	PC3	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.13428213778445497	[1100]	[743,1286,1716,1355]	3	hSpCas9	negative selection	8564732
105034430	105034453	11	-	27260156	PC3	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.04456238052239825	[133]	[81,91,264,142]	-1	hSpCas9	negative selection	8629008
105031164	105031187	11	-	27260156	PC3	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.05848217967897351	[371]	[185,228,738,605]	1	hSpCas9	negative selection	8629009
105033085	105033108	11	+	27260156	PC3	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.28873416525390644	[627]	[630,665,1281,644]	6	hSpCas9	negative selection	8629010
105030415	105030438	11	-	27260156	PATU8988T	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.3841028729915468	[296]	[310,209,175,178]	-6	hSpCas9	negative selection	8685981
105030455	105030478	11	+	27260156	PATU8988T	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.3119042930963769	[1348]	[1370,1581,1864,1649]	5	hSpCas9	negative selection	8685982
105031189	105031212	11	-	27260156	PATU8988T	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.251097901403611	[1100]	[1108,1223,1426,1300]	4	hSpCas9	negative selection	8685983
105034430	105034453	11	-	27260156	PATU8988T	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.12987583970749994	[133]	[57,96,120,201]	-2	hSpCas9	negative selection	8750259
105031164	105031187	11	-	27260156	PATU8988T	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.16505699753043845	[371]	[196,477,265,359]	-3	hSpCas9	negative selection	8750260
105033085	105033108	11	+	27260156	PATU8988T	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.18209490518208699	[627]	[519,699,928,594]	3	hSpCas9	negative selection	8750261
105030415	105030438	11	-	27260156	T47D	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.9138132960945744	[296]	[234,174,165,158]	-9	hSpCas9	negative selection	8807232
105030455	105030478	11	+	27260156	T47D	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	0.028343880357659446	[1348]	[1608,1621,1599,1576]	0	hSpCas9	negative selection	8807233
105031189	105031212	11	-	27260156	T47D	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.11365751207680352	[1100]	[1461,1299,1373,1423]	2	hSpCas9	negative selection	8807234
105034430	105034453	11	-	27260156	T47D	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.14758274869082766	[133]	[139,73,179,175]	-3	hSpCas9	negative selection	8871510
105031164	105031187	11	-	27260156	T47D	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.05137784658882644	[371]	[379,386,491,414]	-1	hSpCas9	negative selection	8871511
105033085	105033108	11	+	27260156	T47D	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.3725755739934639	[627]	[883,891,1048,966]	7	hSpCas9	negative selection	8871512
105030415	105030438	11	-	27260156	SU8686	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.5946730169791272	[296]	[163,146,295,181]	-7	hSpCas9	negative selection	8928483
105030455	105030478	11	+	27260156	SU8686	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.10894101989827276	[1348]	[977,1095,1337,1658]	-2	hSpCas9	negative selection	8928484
105031189	105031212	11	-	27260156	SU8686	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.30633588143766244	[1100]	[1162,1036,1612,1702]	5	hSpCas9	negative selection	8928485
105034430	105034453	11	-	27260156	SU8686	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.04276757921381846	[133]	[95,81,172,183]	0	hSpCas9	negative selection	8992761
105031164	105031187	11	-	27260156	SU8686	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.16710314142997762	[371]	[367,365,362,595]	3	hSpCas9	negative selection	8992762
105033085	105033108	11	+	27260156	SU8686	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.36329562124455833	[627]	[635,786,1079,707]	6	hSpCas9	negative selection	8992763
105030415	105030438	11	-	27260156	SKES1	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.5748366003028855	[296]	[258,224,195,132]	-8	hSpCas9	negative selection	9049734
105030455	105030478	11	+	27260156	SKES1	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.09749525438834006	[1348]	[1593,1456,1029,1036]	-2	hSpCas9	negative selection	9049735
105031189	105031212	11	-	27260156	SKES1	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.05229649515397439	[1100]	[934,1378,1180,1057]	1	hSpCas9	negative selection	9049736
105034430	105034453	11	-	27260156	SKES1	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.21018324164836644	[133]	[227,61,108,75]	-4	hSpCas9	negative selection	9114012
105031164	105031187	11	-	27260156	SKES1	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.3351865494423867	[371]	[276,277,352,263]	-6	hSpCas9	negative selection	9114013
105033085	105033108	11	+	27260156	SKES1	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.32215556567033626	[627]	[861,915,801,593]	6	hSpCas9	negative selection	9114014
105030415	105030438	11	-	27260156	TOV112D	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.36296340558489715	[296]	[276,343,198,138]	-6	hSpCas9	negative selection	9170985
105030455	105030478	11	+	27260156	TOV112D	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.1965801737395798	[1348]	[980,1168,1624,926]	-4	hSpCas9	negative selection	9170986
105031189	105031212	11	-	27260156	TOV112D	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.10287689783532605	[1100]	[1285,1216,1117,1131]	2	hSpCas9	negative selection	9170987
105034430	105034453	11	-	27260156	TOV112D	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.3391831598143451	[133]	[190,109,86,45]	-6	hSpCas9	negative selection	9235263
105031164	105031187	11	-	27260156	TOV112D	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.24386257789029597	[371]	[316,465,180,330]	-5	hSpCas9	negative selection	9235264
105033085	105033108	11	+	27260156	TOV112D	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.36325739651217653	[627]	[745,1571,711,398]	6	hSpCas9	negative selection	9235265
105030415	105030438	11	-	27260156	TC71	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.5813686786109902	[296]	[201,198,241,206]	-9	hSpCas9	negative selection	9292236
105030455	105030478	11	+	27260156	TC71	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.04377930026149679	[1348]	[1364,1380,1342,1532]	-1	hSpCas9	negative selection	9292237
105031189	105031212	11	-	27260156	TC71	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.16468558332274696	[1100]	[1320,1253,1374,1340]	4	hSpCas9	negative selection	9292238
105034430	105034453	11	-	27260156	TC71	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.0911133061682412	[133]	[100,167,166,100]	-2	hSpCas9	negative selection	9356514
105031164	105031187	11	-	27260156	TC71	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.07563095131842962	[371]	[390,376,462,450]	2	hSpCas9	negative selection	9356515
105033085	105033108	11	+	27260156	TC71	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.22708510308563618	[627]	[715,805,786,847]	5	hSpCas9	negative selection	9356516
105030415	105030438	11	-	27260156	TC32	viability	GACAGTATTCCTAGAAGAACTGG	CASP1	ENSG00000137752	-0.6166109621284166	[296]	[164,47,260,319]	-8	hSpCas9	negative selection	9413487
105030455	105030478	11	+	27260156	TC32	viability	TAATGAGAGCAAGACGTGTGCGG	CASP1	ENSG00000137752	-0.2118102184382442	[1348]	[852,929,1531,1170]	-4	hSpCas9	negative selection	9413488
105031189	105031212	11	-	27260156	TC32	viability	GCTCCCTAGAAGAAGCTCAAAGG	CASP1	ENSG00000137752	0.020059323905318838	[1100]	[1004,633,1435,1306]	0	hSpCas9	negative selection	9413489
105034430	105034453	11	-	27260156	TC32	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.24345832945374024	[133]	[127,62,133,112]	-4	hSpCas9	negative selection	9477765
105031164	105031187	11	-	27260156	TC32	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.0049147437324563725	[371]	[180,408,396,403]	0	hSpCas9	negative selection	9477766
105033085	105033108	11	+	27260156	TC32	viability	CTTGAGAGTCTTGCATATTAAGG	CASP1	ENSG00000137752	0.5823943033971715	[627]	[894,711,914,1034]	8	hSpCas9	negative selection	9477767
105029240	105029263	11	+	27869803	HPAFII	viability after 27 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.6668451646314977	[170]	[217,79,NaN]	5	hSpCas9	negative selection	9539510
105029258	105029281	11	-	27869803	HPAFII	viability after 27 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	-0.8684620165836212	[178]	[56,46,NaN]	-6	hSpCas9	negative selection	9539511
105029240	105029263	11	+	27869803	HPAFII	viability after 15 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	0.9957591295789998	[170]	[667,178,NaN]	9	hSpCas9	negative selection	9621959
105029258	105029281	11	-	27869803	HPAFII	viability after 15 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	-0.11215687240064409	[178]	[222,149,NaN]	-1	hSpCas9	negative selection	9621960
105029240	105029263	11	+	27869803	ASPC1	viability after 36 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	1.3442217670852827	[392]	[366,547,172]	9	hSpCas9	negative selection	9704408
105029258	105029281	11	-	27869803	ASPC1	viability after 36 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	0.1981345887357734	[334]	[14,286,94]	2	hSpCas9	negative selection	9704409
105029240	105029263	11	+	27869803	PATU8988S	viability after 35 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	1.1940066037743855	[276]	[140,369,NaN]	9	hSpCas9	negative selection	9786857
105029258	105029281	11	-	27869803	PATU8988S	viability after 35 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	0.5623853319301778	[311]	[211,158,NaN]	6	hSpCas9	negative selection	9786858
105029240	105029263	11	+	27869803	PATU8988S	viability after 31 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	1.1819206334498484	[276]	[210,300,NaN]	9	hSpCas9	negative selection	9869306
105029258	105029281	11	-	27869803	PATU8988S	viability after 31 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	0.6557915075111396	[311]	[206,181,NaN]	7	hSpCas9	negative selection	9869307
105029240	105029263	11	+	27869803	HPAFII	viability after 35 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	1.163266803697034	[170]	[310,61,NaN]	7	hSpCas9	negative selection	9951755
105029258	105029281	11	-	27869803	HPAFII	viability after 35 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	-1.3108875352798341	[178]	[28,44,NaN]	-6	hSpCas9	negative selection	9951756
105029240	105029263	11	+	27869803	HPAFII	viability after 31 days	TCTTTAAACCACACCACACCAGG	CASP1	ENSG00000137752	1.0236942864148522	[170]	[286,94,NaN]	7	hSpCas9	negative selection	10034204
105029258	105029281	11	-	27869803	HPAFII	viability after 31 days	TGTGTCTTTCCAGACAGCCCTGG	CASP1	ENSG00000137752	-0.23367720381547818	[178]	[83,86,NaN]	-1	hSpCas9	negative selection	10034205
105034430	105034453	11	-	28162770	P31FUJ	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.47038637776740305	[120]	[196]	5	hSpCas9	negative selection	10126146
105031235	105031258	11	-	28162770	P31FUJ	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	0.4291222781216617	[437]	[692]	5	hSpCas9	negative selection	10126147
105026291	105026314	11	+	28162770	P31FUJ	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	0.8454066279363186	[735]	[1553]	8	hSpCas9	negative selection	10126148
105026265	105026288	11	-	28162770	P31FUJ	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.23555970328724407	[570]	[789]	2	hSpCas9	negative selection	10126149
105029692	105029715	11	-	28162770	P31FUJ	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	-0.6907918488777692	[249]	[181]	-5	hSpCas9	negative selection	10126150
105031164	105031187	11	-	28162770	P31FUJ	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.3489507398308874	[299]	[448]	4	hSpCas9	negative selection	10126151
105029802	105029825	11	-	28162770	P31FUJ	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	-0.9077068304483333	[181]	[113]	-6	hSpCas9	negative selection	10126152
105029654	105029677	11	+	28162770	P31FUJ	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	-0.37137743432296055	[403]	[366]	-3	hSpCas9	negative selection	10126153
105029667	105029690	11	-	28162770	P31FUJ	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	-0.07327237433444478	[324]	[362]	0	hSpCas9	negative selection	10126154
105031256	105031279	11	+	28162770	P31FUJ	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	0.9371227970279339	[139]	[314]	9	hSpCas9	negative selection	10126155
105034430	105034453	11	-	28162770	TF1	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	NaN	[NaN]	[259]	1	hSpCas9	negative selection	10295512
105031235	105031258	11	-	28162770	TF1	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	NaN	[NaN]	[471]	1	hSpCas9	negative selection	10295513
105026291	105026314	11	+	28162770	TF1	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	NaN	[NaN]	[743]	1	hSpCas9	negative selection	10295514
105026265	105026288	11	-	28162770	TF1	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	NaN	[NaN]	[375]	1	hSpCas9	negative selection	10295515
105029692	105029715	11	-	28162770	TF1	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	NaN	[NaN]	[66]	1	hSpCas9	negative selection	10295516
105031164	105031187	11	-	28162770	TF1	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	NaN	[NaN]	[356]	1	hSpCas9	negative selection	10295517
105029802	105029825	11	-	28162770	TF1	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	NaN	[NaN]	[183]	1	hSpCas9	negative selection	10295518
105029654	105029677	11	+	28162770	TF1	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	NaN	[NaN]	[219]	1	hSpCas9	negative selection	10295519
105029667	105029690	11	-	28162770	TF1	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	NaN	[NaN]	[293]	1	hSpCas9	negative selection	10295520
105031256	105031279	11	+	28162770	TF1	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	NaN	[NaN]	[147]	1	hSpCas9	negative selection	10295521
105034430	105034453	11	-	28162770	SKM1	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.4003907233144425	[38]	[90]	4	hSpCas9	negative selection	10464878
105031235	105031258	11	-	28162770	SKM1	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	0.5425707342738506	[119]	[308]	5	hSpCas9	negative selection	10464879
105026291	105026314	11	+	28162770	SKM1	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	0.7586022040942546	[220]	[660]	7	hSpCas9	negative selection	10464880
105026265	105026288	11	-	28162770	SKM1	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.15415156002362695	[121]	[239]	1	hSpCas9	negative selection	10464881
105029692	105029715	11	-	28162770	SKM1	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	-0.5714582363714086	[57]	[68]	-4	hSpCas9	negative selection	10464882
105031164	105031187	11	-	28162770	SKM1	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.19661398014534143	[76]	[155]	2	hSpCas9	negative selection	10464883
105029802	105029825	11	-	28162770	SKM1	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	0.38311273188260675	[35]	[82]	4	hSpCas9	negative selection	10464884
105029654	105029677	11	+	28162770	SKM1	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	-0.9444857045470005	[85]	[78]	-6	hSpCas9	negative selection	10464885
105029667	105029690	11	-	28162770	SKM1	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	0.07898829614682867	[97]	[182]	0	hSpCas9	negative selection	10464886
105031256	105031279	11	+	28162770	SKM1	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	0.06252108455805849	[51]	[95]	0	hSpCas9	negative selection	10464887
105034430	105034453	11	-	28162770	SKM1	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.4003907233144425	[38]	[90]	4	hSpCas9	negative selection	10634244
105031235	105031258	11	-	28162770	SKM1	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	0.5425707342738506	[119]	[308]	5	hSpCas9	negative selection	10634245
105026291	105026314	11	+	28162770	SKM1	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	0.7586022040942546	[220]	[660]	7	hSpCas9	negative selection	10634246
105026265	105026288	11	-	28162770	SKM1	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.15415156002362695	[121]	[239]	1	hSpCas9	negative selection	10634247
105029692	105029715	11	-	28162770	SKM1	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	-0.5714582363714086	[57]	[68]	-4	hSpCas9	negative selection	10634248
105031164	105031187	11	-	28162770	SKM1	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.19661398014534143	[76]	[155]	2	hSpCas9	negative selection	10634249
105029802	105029825	11	-	28162770	SKM1	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	0.38311273188260675	[35]	[82]	4	hSpCas9	negative selection	10634250
105029654	105029677	11	+	28162770	SKM1	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	-0.9444857045470005	[85]	[78]	-6	hSpCas9	negative selection	10634251
105029667	105029690	11	-	28162770	SKM1	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	0.07898829614682867	[97]	[182]	0	hSpCas9	negative selection	10634252
105031256	105031279	11	+	28162770	SKM1	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	0.06252108455805849	[51]	[95]	0	hSpCas9	negative selection	10634253
105034430	105034453	11	-	28162770	PL21	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.46665458905807594	[137]	[82]	4	hSpCas9	negative selection	10803610
105031235	105031258	11	-	28162770	PL21	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	0.5991597164307956	[316]	[208]	5	hSpCas9	negative selection	10803611
105026291	105026314	11	+	28162770	PL21	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	0.8839707888906427	[624]	[501]	7	hSpCas9	negative selection	10803612
105026265	105026288	11	-	28162770	PL21	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.5972349430578077	[444]	[292]	5	hSpCas9	negative selection	10803613
105029692	105029715	11	-	28162770	PL21	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	0.5029358491984864	[166]	[102]	4	hSpCas9	negative selection	10803614
105031164	105031187	11	-	28162770	PL21	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.22597961942457967	[331]	[168]	2	hSpCas9	negative selection	10803615
105029802	105029825	11	-	28162770	PL21	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	0.16771813679694259	[134]	[65]	1	hSpCas9	negative selection	10803616
105029654	105029677	11	+	28162770	PL21	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	0.22314959253582056	[310]	[157]	2	hSpCas9	negative selection	10803617
105029667	105029690	11	-	28162770	PL21	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	0.8591026966542531	[303]	[239]	7	hSpCas9	negative selection	10803618
105031256	105031279	11	+	28162770	PL21	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	-0.49102229006376125	[154]	[47]	-4	hSpCas9	negative selection	10803619
105034430	105034453	11	-	28162770	P31FUJ	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.47038637776740305	[120]	[196]	5	hSpCas9	negative selection	10972976
105031235	105031258	11	-	28162770	P31FUJ	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	0.4291222781216617	[437]	[692]	5	hSpCas9	negative selection	10972977
105026291	105026314	11	+	28162770	P31FUJ	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	0.8454066279363186	[735]	[1553]	8	hSpCas9	negative selection	10972978
105026265	105026288	11	-	28162770	P31FUJ	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.23555970328724407	[570]	[789]	2	hSpCas9	negative selection	10972979
105029692	105029715	11	-	28162770	P31FUJ	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	-0.6907918488777692	[249]	[181]	-5	hSpCas9	negative selection	10972980
105031164	105031187	11	-	28162770	P31FUJ	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.3489507398308874	[299]	[448]	4	hSpCas9	negative selection	10972981
105029802	105029825	11	-	28162770	P31FUJ	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	-0.9077068304483333	[181]	[113]	-6	hSpCas9	negative selection	10972982
105029654	105029677	11	+	28162770	P31FUJ	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	-0.37137743432296055	[403]	[366]	-3	hSpCas9	negative selection	10972983
105029667	105029690	11	-	28162770	P31FUJ	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	-0.07327237433444478	[324]	[362]	0	hSpCas9	negative selection	10972984
105031256	105031279	11	+	28162770	P31FUJ	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	0.9371227970279339	[139]	[314]	9	hSpCas9	negative selection	10972985
105034430	105034453	11	-	28162770	OCIAML5	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.3948481696065199	[74]	[177]	3	hSpCas9	negative selection	11142342
105031235	105031258	11	-	28162770	OCIAML5	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	0.9877503591507928	[225]	[808]	8	hSpCas9	negative selection	11142343
105026291	105026314	11	+	28162770	OCIAML5	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	0.3553433859413193	[400]	[925]	3	hSpCas9	negative selection	11142344
105026265	105026288	11	-	28162770	OCIAML5	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.019200115013799923	[286]	[524]	0	hSpCas9	negative selection	11142345
105029692	105029715	11	-	28162770	OCIAML5	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	0.45244447094595613	[99]	[246]	4	hSpCas9	negative selection	11142346
105031164	105031187	11	-	28162770	OCIAML5	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.30797384164647135	[178]	[399]	2	hSpCas9	negative selection	11142347
105029802	105029825	11	-	28162770	OCIAML5	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	-0.20275365873278323	[94]	[148]	-1	hSpCas9	negative selection	11142348
105029654	105029677	11	+	28162770	OCIAML5	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	-0.6428034214711839	[204]	[236]	-4	hSpCas9	negative selection	11142349
105029667	105029690	11	-	28162770	OCIAML5	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	-0.17399466575135925	[189]	[303]	-1	hSpCas9	negative selection	11142350
105031256	105031279	11	+	28162770	OCIAML5	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	1.5660768392826685	[86]	[464]	9	hSpCas9	negative selection	11142351
105034430	105034453	11	-	28162770	EOL1	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.86889974202062	[184]	[177]	7	hSpCas9	negative selection	11311708
105031235	105031258	11	-	28162770	EOL1	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	0.6165738481979348	[462]	[373]	5	hSpCas9	negative selection	11311709
105026291	105026314	11	+	28162770	EOL1	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	0.8894500709211399	[1164]	[1136]	7	hSpCas9	negative selection	11311710
105026265	105026288	11	-	28162770	EOL1	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.43460546327780003	[895]	[637]	4	hSpCas9	negative selection	11311711
105029692	105029715	11	-	28162770	EOL1	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	0.06052544108950908	[343]	[188]	0	hSpCas9	negative selection	11311712
105031164	105031187	11	-	28162770	EOL1	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.16135063583114906	[554]	[326]	1	hSpCas9	negative selection	11311713
105029802	105029825	11	-	28162770	EOL1	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	-0.6769028519391908	[175]	[57]	-5	hSpCas9	negative selection	11311714
105029654	105029677	11	+	28162770	EOL1	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	-0.6044765575567641	[429]	[148]	-4	hSpCas9	negative selection	11311715
105029667	105029690	11	-	28162770	EOL1	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	0.8290674627163062	[405]	[379]	7	hSpCas9	negative selection	11311716
105031256	105031279	11	+	28162770	EOL1	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	1.415388094927141	[189]	[266]	9	hSpCas9	negative selection	11311717
105034430	105034453	11	-	28162770	MOLM13	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	1.6317754665055508	[132]	[297]	9	hSpCas9	negative selection	11481074
105031235	105031258	11	-	28162770	MOLM13	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	0.04300409630938784	[587]	[437]	0	hSpCas9	negative selection	11481075
105026291	105026314	11	+	28162770	MOLM13	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	1.2862725213956223	[874]	[1542]	8	hSpCas9	negative selection	11481076
105026265	105026288	11	-	28162770	MOLM13	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.18409641554398748	[755]	[620]	1	hSpCas9	negative selection	11481077
105029692	105029715	11	-	28162770	MOLM13	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	0.4010344067883274	[264]	[252]	3	hSpCas9	negative selection	11481078
105031164	105031187	11	-	28162770	MOLM13	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.4951394159527793	[471]	[480]	3	hSpCas9	negative selection	11481079
105029802	105029825	11	-	28162770	MOLM13	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	-1.052942781756862	[197]	[68]	-5	hSpCas9	negative selection	11481080
105029654	105029677	11	+	28162770	MOLM13	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	-1.612204209668668	[536]	[126]	-7	hSpCas9	negative selection	11481081
105029667	105029690	11	-	28162770	MOLM13	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	0.10812446547975546	[366]	[285]	0	hSpCas9	negative selection	11481082
105031256	105031279	11	+	28162770	MOLM13	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	-0.19507563117785054	[189]	[119]	-1	hSpCas9	negative selection	11481083
105034430	105034453	11	-	28162770	HEL	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.5525410230287788	[164]	[154]	5	hSpCas9	negative selection	11650440
105031235	105031258	11	-	28162770	HEL	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	0.6727109117514161	[523]	[534]	6	hSpCas9	negative selection	11650441
105026291	105026314	11	+	28162770	HEL	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	1.2235043987336496	[917]	[1372]	9	hSpCas9	negative selection	11650442
105026265	105026288	11	-	28162770	HEL	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.6603866978197814	[649]	[657]	5	hSpCas9	negative selection	11650443
105029692	105029715	11	-	28162770	HEL	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	0.5736971875707055	[213]	[203]	5	hSpCas9	negative selection	11650444
105031164	105031187	11	-	28162770	HEL	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.8830977998662538	[341]	[403]	7	hSpCas9	negative selection	11650445
105029802	105029825	11	-	28162770	HEL	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	0.1612059209346064	[147]	[105]	1	hSpCas9	negative selection	11650446
105029654	105029677	11	+	28162770	HEL	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	-1.095469929016481	[386]	[115]	-6	hSpCas9	negative selection	11650447
105029667	105029690	11	-	28162770	HEL	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	-0.05822674546527029	[342]	[210]	0	hSpCas9	negative selection	11650448
105031256	105031279	11	+	28162770	HEL	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	0.7012910143554698	[168]	[175]	6	hSpCas9	negative selection	11650449
105034430	105034453	11	-	28162770	MV411	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	0.946168926461506	[129]	[210]	8	hSpCas9	negative selection	11819806
105031235	105031258	11	-	28162770	MV411	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	0.2222212651739386	[403]	[396]	2	hSpCas9	negative selection	11819807
105026291	105026314	11	+	28162770	MV411	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	0.6508911212040411	[718]	[950]	6	hSpCas9	negative selection	11819808
105026265	105026288	11	-	28162770	MV411	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.30581312345767797	[556]	[579]	2	hSpCas9	negative selection	11819809
105029692	105029715	11	-	28162770	MV411	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	0.0961939704065379	[210]	[189]	0	hSpCas9	negative selection	11819810
105031164	105031187	11	-	28162770	MV411	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.10157007816087149	[362]	[284]	-1	hSpCas9	negative selection	11819811
105029802	105029825	11	-	28162770	MV411	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	1.2320075102131691	[93]	[185]	9	hSpCas9	negative selection	11819812
105029654	105029677	11	+	28162770	MV411	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	-0.09269513948217767	[318]	[251]	0	hSpCas9	negative selection	11819813
105029667	105029690	11	-	28162770	MV411	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	0.40634114613383554	[291]	[325]	3	hSpCas9	negative selection	11819814
105031256	105031279	11	+	28162770	MV411	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	0.814206934737962	[132]	[196]	7	hSpCas9	negative selection	11819815
105034430	105034453	11	-	28162770	MONOMAC1	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.111645355828909	[81]	[86]	-1	hSpCas9	negative selection	11989172
105031235	105031258	11	-	28162770	MONOMAC1	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	0.40020398344003916	[233]	[353]	4	hSpCas9	negative selection	11989173
105026291	105026314	11	+	28162770	MONOMAC1	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	0.7215587646566177	[400]	[757]	7	hSpCas9	negative selection	11989174
105026265	105026288	11	-	28162770	MONOMAC1	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	-0.1686550456897311	[301]	[307]	-1	hSpCas9	negative selection	11989175
105029692	105029715	11	-	28162770	MONOMAC1	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	-1.166663198016035	[140]	[71]	-7	hSpCas9	negative selection	11989176
105031164	105031187	11	-	28162770	MONOMAC1	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.1301278961939557	[219]	[275]	1	hSpCas9	negative selection	11989177
105029802	105029825	11	-	28162770	MONOMAC1	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	1.7265500374212783	[62]	[238]	9	hSpCas9	negative selection	11989178
105029654	105029677	11	+	28162770	MONOMAC1	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	-1.204690419602989	[188]	[93]	-7	hSpCas9	negative selection	11989179
105029667	105029690	11	-	28162770	MONOMAC1	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	0.6342086952060717	[153]	[273]	6	hSpCas9	negative selection	11989180
105031256	105031279	11	+	28162770	MONOMAC1	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	0.661787089979752	[117]	[213]	6	hSpCas9	negative selection	11989181
105034430	105034453	11	-	28162770	OCIAML2	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	-0.10563300846291288	[32]	[169]	-1	hSpCas9	negative selection	12158538
105031235	105031258	11	-	28162770	OCIAML2	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	0.1629128559240567	[72]	[452]	1	hSpCas9	negative selection	12158539
105026291	105026314	11	+	28162770	OCIAML2	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	0.41860210386985064	[136]	[1014]	4	hSpCas9	negative selection	12158540
105026265	105026288	11	-	28162770	OCIAML2	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.8674630890762083	[70]	[717]	8	hSpCas9	negative selection	12158541
105029692	105029715	11	-	28162770	OCIAML2	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	0.20866005802714815	[36]	[236]	2	hSpCas9	negative selection	12158542
105031164	105031187	11	-	28162770	OCIAML2	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	0.7561410366048611	[46]	[439]	7	hSpCas9	negative selection	12158543
105029802	105029825	11	-	28162770	OCIAML2	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	-0.4543280129130607	[21]	[88]	-4	hSpCas9	negative selection	12158544
105029654	105029677	11	+	28162770	OCIAML2	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	0.10427901081507207	[47]	[285]	1	hSpCas9	negative selection	12158545
105029667	105029690	11	-	28162770	OCIAML2	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	-0.16946029052159628	[55]	[275]	-1	hSpCas9	negative selection	12158546
105031256	105031279	11	+	28162770	OCIAML2	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	0.36976535857945053	[36]	[264]	3	hSpCas9	negative selection	12158547
105034430	105034453	11	-	28162770	OCIAML3	viability	AAAGCTGTTTATCCGTTCCATGG	CASP1	ENSG00000137752	1.3097770444165338	[30]	[231]	9	hSpCas9	negative selection	12327904
105031235	105031258	11	-	28162770	OCIAML3	viability	CCAGCTATGCCCACATCCTCAGG	CASP1	ENSG00000137752	1.0026366654446284	[122]	[743]	8	hSpCas9	negative selection	12327905
105026291	105026314	11	+	28162770	OCIAML3	viability	CAAAGTCACTCTTTCAGTGGTGG	CASP1	ENSG00000137752	0.8240040509331532	[211]	[1132]	7	hSpCas9	negative selection	12327906
105026265	105026288	11	-	28162770	OCIAML3	viability	AGATGTTTCTACCTCTTCCCAGG	CASP1	ENSG00000137752	0.3319917782320603	[139]	[531]	3	hSpCas9	negative selection	12327907
105029692	105029715	11	-	28162770	OCIAML3	viability	AAGTTTGAAGGACAAACCGAAGG	CASP1	ENSG00000137752	0.6076262208454873	[49]	[229]	5	hSpCas9	negative selection	12327908
105031164	105031187	11	-	28162770	OCIAML3	viability	ATGGAAACAAAAGTCGGCAGAGG	CASP1	ENSG00000137752	-0.8376767212910259	[73]	[124]	-6	hSpCas9	negative selection	12327909
105029802	105029825	11	-	28162770	OCIAML3	viability	ATGTCTCATGGTATTCGGGAAGG	CASP1	ENSG00000137752	0.8002712987878833	[34]	[183]	7	hSpCas9	negative selection	12327910
105029654	105029677	11	+	28162770	OCIAML3	viability	TCAGCACTCACCACCACGGCAGG	CASP1	ENSG00000137752	0.36018867006271216	[87]	[340]	3	hSpCas9	negative selection	12327911
105029667	105029690	11	-	28162770	OCIAML3	viability	ATCATCATCCAGGCCTGCCGTGG	CASP1	ENSG00000137752	-0.2773352708882961	[54]	[136]	-2	hSpCas9	negative selection	12327912
105031256	105031279	11	+	28162770	OCIAML3	viability	GGGTTGTCCTGCACTGCCTGAGG	CASP1	ENSG00000137752	0.36751821186120126	[37]	[147]	3	hSpCas9	negative selection	12327913