| 59439789 | 59439812 | 18 | - | 26472758 | Jiyoye | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | -0.3786998131412791 | [49] | [28] | -3 | hSpCas9 | negative selection | 24398 | 59466762 | 59466785 | 18 | - | 26472758 | Jiyoye | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 1.3556450808657912 | [113] | [219] | 7 | hSpCas9 | negative selection | 24399 | 59439763 | 59439786 | 18 | + | 26472758 | Jiyoye | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 0.9992976737998955 | [66] | [100] | 6 | hSpCas9 | negative selection | 24400 | 59466864 | 59466887 | 18 | - | 26472758 | Jiyoye | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | 0.1255437567947495 | [202] | [166] | 1 | hSpCas9 | negative selection | 24401 | 59439550 | 59439573 | 18 | - | 26472758 | Jiyoye | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | 6.850118877354602 | [0] | [86] | 9 | hSpCas9 | negative selection | 24402 | 59469498 | 59469521 | 18 | - | 26472758 | Jiyoye | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 1.1089515472097797 | [82] | [134] | 7 | hSpCas9 | negative selection | 24403 | 59466806 | 59466829 | 18 | - | 26472758 | Jiyoye | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | -2.746629954573162 | [88] | [9] | -9 | hSpCas9 | negative selection | 24404 | 59439789 | 59439812 | 18 | - | 26472758 | KBM7 | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | 1.122717020037434 | [136,144] | [107,178] | 9 | hSpCas9 | negative selection | 215516 | 59466762 | 59466785 | 18 | - | 26472758 | KBM7 | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 0.056172343027919236 | [725,509] | [256,334] | 0 | hSpCas9 | negative selection | 215517 | 59439763 | 59439786 | 18 | + | 26472758 | KBM7 | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 0.46259127094262265 | [339,145] | [136,164] | 5 | hSpCas9 | negative selection | 215518 | 59466864 | 59466887 | 18 | - | 26472758 | KBM7 | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | 0.8289348227961308 | [647,579] | [664,375] | 8 | hSpCas9 | negative selection | 215519 | 59439550 | 59439573 | 18 | - | 26472758 | KBM7 | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | 0.8895232129181395 | [144,232] | [124,208] | 8 | hSpCas9 | negative selection | 215520 | 59469498 | 59469521 | 18 | - | 26472758 | KBM7 | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 1.2447778478926799 | [545,514] | [672,519] | 9 | hSpCas9 | negative selection | 215521 | 59466806 | 59466829 | 18 | - | 26472758 | KBM7 | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | 0.625154150005724 | [117,178] | [91,126] | 6 | hSpCas9 | negative selection | 215522 | 59439789 | 59439812 | 18 | - | 26472758 | Raji | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | 0.10738353537359946 | [91] | [22] | 1 | hSpCas9 | negative selection | 406634 | 59466762 | 59466785 | 18 | - | 26472758 | Raji | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 0.25835943401492184 | [280] | [77] | 2 | hSpCas9 | negative selection | 406635 | 59439763 | 59439786 | 18 | + | 26472758 | Raji | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 0.3086417436207033 | [166] | [47] | 3 | hSpCas9 | negative selection | 406636 | 59466864 | 59466887 | 18 | - | 26472758 | Raji | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | 0.22076533479134208 | [317] | [85] | 2 | hSpCas9 | negative selection | 406637 | 59439550 | 59439573 | 18 | - | 26472758 | Raji | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | 0.07679521554017665 | [142] | [34] | 0 | hSpCas9 | negative selection | 406638 | 59469498 | 59469521 | 18 | - | 26472758 | Raji | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.3862843466664143 | [210] | [63] | 3 | hSpCas9 | negative selection | 406639 | 59466806 | 59466829 | 18 | - | 26472758 | Raji | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | -1.2000449898186478 | [98] | [9] | -7 | hSpCas9 | negative selection | 406640 | 59439789 | 59439812 | 18 | - | 26472758 | K562 | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | 1.1878351993000797 | [103] | [199] | 8 | hSpCas9 | negative selection | 597752 | 59466762 | 59466785 | 18 | - | 26472758 | K562 | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 0.23571903271606143 | [498] | [495] | 1 | hSpCas9 | negative selection | 597753 | 59439763 | 59439786 | 18 | + | 26472758 | K562 | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 0.19666559621807878 | [214] | [207] | 1 | hSpCas9 | negative selection | 597754 | 59466864 | 59466887 | 18 | - | 26472758 | K562 | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | 1.0355038102475396 | [585] | [1013] | 8 | hSpCas9 | negative selection | 597755 | 59439550 | 59439573 | 18 | - | 26472758 | K562 | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | 0.8791342635847026 | [189] | [294] | 7 | hSpCas9 | negative selection | 597756 | 59469498 | 59469521 | 18 | - | 26472758 | K562 | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.26762611882777215 | [369] | [375] | 2 | hSpCas9 | negative selection | 597757 | 59466806 | 59466829 | 18 | - | 26472758 | K562 | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | 2.137048630149796 | [121] | [452] | 9 | hSpCas9 | negative selection | 597758 | 59454850 | 59454873 | 18 | - | 26627737 | DLD1 | viability | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.3644270081425032 | [2171] | [789,978,859] | 4 | hSpCas9 | negative selection | 801825 | 59466763 | 59466786 | 18 | - | 26627737 | DLD1 | viability | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | 0.2799548961851316 | [801] | [258,233,401] | 3 | hSpCas9 | negative selection | 801826 | 59469498 | 59469521 | 18 | - | 26627737 | DLD1 | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 2.162439224819247 | [63] | [71,11,168] | 9 | hSpCas9 | negative selection | 801827 | 59480185 | 59480208 | 18 | - | 26627737 | DLD1 | viability | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 0.3805724104525898 | [401] | [174,219,106] | 4 | hSpCas9 | negative selection | 801828 | 59454850 | 59454873 | 18 | - | 26627737 | GBM cells | viability after 5 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.15045264188164964 | [1112] | [632,691] | 2 | hSpCas9 | negative selection | 884140 | 59466763 | 59466786 | 18 | - | 26627737 | GBM cells | viability after 5 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.2683808705119547 | [410] | [211,153] | -4 | hSpCas9 | negative selection | 884141 | 59469498 | 59469521 | 18 | - | 26627737 | GBM cells | viability after 5 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.537185239920988 | [91] | [29,37] | -7 | hSpCas9 | negative selection | 884142 | 59480185 | 59480208 | 18 | - | 26627737 | GBM cells | viability after 5 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 0.25566955832613625 | [220] | [122,159] | 4 | hSpCas9 | negative selection | 884143 | 59454850 | 59454873 | 18 | - | 26627737 | GBM cells | viability after 13 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.18681881749752982 | [1112] | [752,633] | 2 | hSpCas9 | negative selection | 966455 | 59466763 | 59466786 | 18 | - | 26627737 | GBM cells | viability after 13 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.11002045081092171 | [410] | [215,198] | -1 | hSpCas9 | negative selection | 966456 | 59469498 | 59469521 | 18 | - | 26627737 | GBM cells | viability after 13 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.06122315322089378 | [91] | [77,30] | 0 | hSpCas9 | negative selection | 966457 | 59480185 | 59480208 | 18 | - | 26627737 | GBM cells | viability after 13 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 0.8628227695968629 | [220] | [286,161] | 8 | hSpCas9 | negative selection | 966458 | 59454850 | 59454873 | 18 | - | 26627737 | GBM cells | viability after 21 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.351808626403848 | [1112] | [814,731] | 3 | hSpCas9 | negative selection | 1048770 | 59466763 | 59466786 | 18 | - | 26627737 | GBM cells | viability after 21 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.034944665431241306 | [410] | [230,205] | 0 | hSpCas9 | negative selection | 1048771 | 59469498 | 59469521 | 18 | - | 26627737 | GBM cells | viability after 21 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.8955832235219057 | [91] | [29,23] | -7 | hSpCas9 | negative selection | 1048772 | 59480185 | 59480208 | 18 | - | 26627737 | GBM cells | viability after 21 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 0.6686681121290304 | [220] | [205,176] | 6 | hSpCas9 | negative selection | 1048773 | 59454850 | 59454873 | 18 | - | 26627737 | RPE1 | viability after 9 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.43502687752175895 | [4258] | [1551,2125] | 3 | hSpCas9 | negative selection | 1131085 | 59466763 | 59466786 | 18 | - | 26627737 | RPE1 | viability after 9 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.14489854016578196 | [1597] | [441,465] | -1 | hSpCas9 | negative selection | 1131086 | 59469498 | 59469521 | 18 | - | 26627737 | RPE1 | viability after 9 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.4600983217677854 | [328] | [173,99] | 3 | hSpCas9 | negative selection | 1131087 | 59480185 | 59480208 | 18 | - | 26627737 | RPE1 | viability after 9 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 1.0378549837749818 | [460] | [208,408] | 6 | hSpCas9 | negative selection | 1131088 | 59454850 | 59454873 | 18 | - | 26627737 | RPE1 | viability after 12 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.46950727183737273 | [4258] | [1579,1588] | 3 | hSpCas9 | negative selection | 1213400 | 59466763 | 59466786 | 18 | - | 26627737 | RPE1 | viability after 12 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.37363487526741346 | [1597] | [377,281] | -3 | hSpCas9 | negative selection | 1213401 | 59469498 | 59469521 | 18 | - | 26627737 | RPE1 | viability after 12 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.21062849314454857 | [328] | [128,73] | 1 | hSpCas9 | negative selection | 1213402 | 59480185 | 59480208 | 18 | - | 26627737 | RPE1 | viability after 12 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 1.2077921193796337 | [460] | [288,282] | 7 | hSpCas9 | negative selection | 1213403 | 59454850 | 59454873 | 18 | - | 26627737 | RPE1 | viability after 15 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.4844921031389906 | [4258] | [1848,1527] | 3 | hSpCas9 | negative selection | 1295715 | 59466763 | 59466786 | 18 | - | 26627737 | RPE1 | viability after 15 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.13507042806042646 | [1597] | [431,391] | -1 | hSpCas9 | negative selection | 1295716 | 59469498 | 59469521 | 18 | - | 26627737 | RPE1 | viability after 15 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.7921538729565722 | [328] | [39,66] | -5 | hSpCas9 | negative selection | 1295717 | 59480185 | 59480208 | 18 | - | 26627737 | RPE1 | viability after 15 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 0.9859463631585319 | [460] | [185,327] | 6 | hSpCas9 | negative selection | 1295718 | 59454850 | 59454873 | 18 | - | 26627737 | RPE1 | viability after 18 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.5901350228775191 | [4258] | [1722,1737] | 3 | hSpCas9 | negative selection | 1378030 | 59466763 | 59466786 | 18 | - | 26627737 | RPE1 | viability after 18 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | 0.015267600307591556 | [1597] | [401,471] | 0 | hSpCas9 | negative selection | 1378031 | 59469498 | 59469521 | 18 | - | 26627737 | RPE1 | viability after 18 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.33209389875297535 | [328] | [85,53] | -2 | hSpCas9 | negative selection | 1378032 | 59480185 | 59480208 | 18 | - | 26627737 | RPE1 | viability after 18 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 1.047361426235883 | [460] | [216,299] | 6 | hSpCas9 | negative selection | 1378033 | 59454850 | 59454873 | 18 | - | 26627737 | HeLa | viability after 8 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.16389679272228586 | [1764] | [1049,979,610] | 1 | hSpCas9 | negative selection | 1460345 | 59466763 | 59466786 | 18 | - | 26627737 | HeLa | viability after 8 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.5161788606120977 | [1017] | [192,422,288] | -5 | hSpCas9 | negative selection | 1460346 | 59469498 | 59469521 | 18 | - | 26627737 | HeLa | viability after 8 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 1.2992994240067635 | [60] | [7,163,14] | 8 | hSpCas9 | negative selection | 1460347 | 59480185 | 59480208 | 18 | - | 26627737 | HeLa | viability after 8 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | -0.42417501101655386 | [585] | [177,251,140] | -4 | hSpCas9 | negative selection | 1460348 | 59454850 | 59454873 | 18 | - | 26627737 | HeLa | viability after 12 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.4157670562021587 | [1764] | [1153,787,1001] | 3 | hSpCas9 | negative selection | 1542660 | 59466763 | 59466786 | 18 | - | 26627737 | HeLa | viability after 12 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -1.1683446191412348 | [1017] | [94,185,277] | -8 | hSpCas9 | negative selection | 1542661 | 59469498 | 59469521 | 18 | - | 26627737 | HeLa | viability after 12 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.5944891365301523 | [60] | [27,55,27] | 5 | hSpCas9 | negative selection | 1542662 | 59480185 | 59480208 | 18 | - | 26627737 | HeLa | viability after 12 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | -0.7204491800245234 | [585] | [304,66,81] | -6 | hSpCas9 | negative selection | 1542663 | 59454850 | 59454873 | 18 | - | 26627737 | HeLa | viability after 15 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.5226561054964192 | [1764] | [1100,1443,510] | 4 | hSpCas9 | negative selection | 1624975 | 59466763 | 59466786 | 18 | - | 26627737 | HeLa | viability after 15 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.8313312416806431 | [1017] | [141,166,403] | -6 | hSpCas9 | negative selection | 1624976 | 59469498 | 59469521 | 18 | - | 26627737 | HeLa | viability after 15 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.9856638517244589 | [60] | [46,45,54] | 7 | hSpCas9 | negative selection | 1624977 | 59480185 | 59480208 | 18 | - | 26627737 | HeLa | viability after 15 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | -0.034212459570665876 | [585] | [247,310,131] | 0 | hSpCas9 | negative selection | 1624978 | 59454850 | 59454873 | 18 | - | 26627737 | HeLa | viability after 18 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.5322018995704094 | [1764] | [746,1201,510] | 4 | hSpCas9 | negative selection | 1707290 | 59466763 | 59466786 | 18 | - | 26627737 | HeLa | viability after 18 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.7926907301461903 | [1017] | [110,133,403] | -6 | hSpCas9 | negative selection | 1707291 | 59469498 | 59469521 | 18 | - | 26627737 | HeLa | viability after 18 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 1.044667581113101 | [60] | [37,34,54] | 7 | hSpCas9 | negative selection | 1707292 | 59480185 | 59480208 | 18 | - | 26627737 | HeLa | viability after 18 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | -0.017162757575352128 | [585] | [176,250,131] | 0 | hSpCas9 | negative selection | 1707293 | 59454850 | 59454873 | 18 | - | 26627737 | HCT116 | viability after 6 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.0346655736594641 | [2125] | [507,250] | 0 | hSpCas9 | negative selection | 1789605 | 59466763 | 59466786 | 18 | - | 26627737 | HCT116 | viability after 6 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | 1.2950117308164595 | [900] | [295,375] | 7 | hSpCas9 | negative selection | 1789606 | 59469498 | 59469521 | 18 | - | 26627737 | HCT116 | viability after 6 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.4443086738931872 | [184] | [41,9] | -3 | hSpCas9 | negative selection | 1789607 | 59480185 | 59480208 | 18 | - | 26627737 | HCT116 | viability after 6 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | -2.003044751258813 | [624] | [19,26] | -8 | hSpCas9 | negative selection | 1789608 | 59454850 | 59454873 | 18 | - | 26627737 | HCT116 | viability after 8 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.11203925650549662 | [1373] | [707,861,881] | 1 | hSpCas9 | negative selection | 1871920 | 59466763 | 59466786 | 18 | - | 26627737 | HCT116 | viability after 8 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.0033512976684881846 | [522] | [318,246,296] | 0 | hSpCas9 | negative selection | 1871921 | 59469498 | 59469521 | 18 | - | 26627737 | HCT116 | viability after 8 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.22846869944433434 | [79] | [32,19,100] | 2 | hSpCas9 | negative selection | 1871922 | 59480185 | 59480208 | 18 | - | 26627737 | HCT116 | viability after 8 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 0.13649777442060476 | [296] | [164,159,213] | 1 | hSpCas9 | negative selection | 1871923 | 59454850 | 59454873 | 18 | - | 26627737 | HCT116 | viability after 9 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.04213426257689323 | [2125] | [655,527] | 0 | hSpCas9 | negative selection | 1954235 | 59466763 | 59466786 | 18 | - | 26627737 | HCT116 | viability after 9 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | 0.31378205555016914 | [900] | [312,287] | 2 | hSpCas9 | negative selection | 1954236 | 59469498 | 59469521 | 18 | - | 26627737 | HCT116 | viability after 9 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.7444096284681863 | [184] | [0,51] | -5 | hSpCas9 | negative selection | 1954237 | 59480185 | 59480208 | 18 | - | 26627737 | HCT116 | viability after 9 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | -2.239764614353938 | [624] | [55,18] | -9 | hSpCas9 | negative selection | 1954238 | 59454850 | 59454873 | 18 | - | 26627737 | HCT116 | viability after 12 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.2103683016752642 | [1373] | [803,874,830] | 2 | hSpCas9 | negative selection | 2036550 | 59466763 | 59466786 | 18 | - | 26627737 | HCT116 | viability after 12 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.13278870926352326 | [522] | [303,276,166] | -1 | hSpCas9 | negative selection | 2036551 | 59469498 | 59469521 | 18 | - | 26627737 | HCT116 | viability after 12 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.07813232524156 | [79] | [49,56,11] | -1 | hSpCas9 | negative selection | 2036552 | 59480185 | 59480208 | 18 | - | 26627737 | HCT116 | viability after 12 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | -0.08201013434718508 | [296] | [121,204,118] | -1 | hSpCas9 | negative selection | 2036553 | 59454850 | 59454873 | 18 | - | 26627737 | HCT116 | viability after 15 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.3133641498924882 | [1373] | [1201,827,938] | 3 | hSpCas9 | negative selection | 2118865 | 59466763 | 59466786 | 18 | - | 26627737 | HCT116 | viability after 15 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.15166553161293217 | [522] | [409,135,281] | -1 | hSpCas9 | negative selection | 2118866 | 59469498 | 59469521 | 18 | - | 26627737 | HCT116 | viability after 15 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.12865361110923357 | [79] | [25,45,51] | -1 | hSpCas9 | negative selection | 2118867 | 59480185 | 59480208 | 18 | - | 26627737 | HCT116 | viability after 15 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | -0.4797174056260951 | [296] | [112,145,106] | -5 | hSpCas9 | negative selection | 2118868 | 59454850 | 59454873 | 18 | - | 26627737 | HCT116 | viability after 18 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.6956081704060506 | [1373] | [1116,1079,1027] | 6 | hSpCas9 | negative selection | 2201180 | 59466763 | 59466786 | 18 | - | 26627737 | HCT116 | viability after 18 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.014684353190024924 | [522] | [238,364,133] | 0 | hSpCas9 | negative selection | 2201181 | 59469498 | 59469521 | 18 | - | 26627737 | HCT116 | viability after 18 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.8005596710824048 | [79] | [5,16,44] | -6 | hSpCas9 | negative selection | 2201182 | 59480185 | 59480208 | 18 | - | 26627737 | HCT116 | viability after 18 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 0.3626701912333443 | [296] | [271,61,229] | 3 | hSpCas9 | negative selection | 2201183 | 59625378 | 59625401 | 18 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GGAGCGCAGTGGCGCGATCTTGG | CCBE1 | ENSG00000183287 | -0.814608194487327 | [84,35] | [10,2] | -4 | dCas9-VP64 | positive selection | 2398692 | 59601059 | 59601082 | 18 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TCTCACTCTGTCTCCCAGGCTGG | CCBE1 | ENSG00000183287 | -0.22926698104333687 | [120,197] | [15,43] | -1 | dCas9-VP64 | positive selection | 2418693 | 59442651 | 59442674 | 18 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TCACTGCAATCTCTGCCTCCCAG | CCBE1 | ENSG00000183287 | 0.009160240507729789 | [175,457] | [15,128] | 0 | dCas9-VP64 | positive selection | 2425902 | 59691443 | 59691466 | 18 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TTGCCCAGGCTGGAGTGCAGTGG | CCBE1 | ENSG00000183287 | 0.9977856233970179 | [9,4] | [4,0] | 4 | dCas9-VP64 | positive selection | 2435978 | 59614275 | 59614298 | 18 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAGGCATGAGCCATCGTGCCTGG | CCBE1 | ENSG00000183287 | -2.3680687732448105 | [443,16] | [15,1] | -9 | dCas9-VP64 | positive selection | 2440326 | 59625386 | 59625409 | 18 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GCGCCACTGCGCTCCAGCCTGGG | CCBE1 | ENSG00000183287 | -0.692868363357688 | [238,335] | [46,29] | -4 | dCas9-VP64 | positive selection | 2440987 | 59450606 | 59450629 | 18 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TCACTACAACCTCTGCCTCCCAG | CCBE1 | ENSG00000183287 | 0.3736894149735144 | [619,564] | [67,277] | 1 | dCas9-VP64 | positive selection | 2443997 | 59589763 | 59589786 | 18 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GGAGTCTCGCTCTGTCGCCCTGG | CCBE1 | ENSG00000183287 | -0.5315818005101806 | [14,129] | [5,15] | -3 | dCas9-VP64 | positive selection | 2444290 | 59569758 | 59569781 | 18 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CACCTGTAATCTCAGCTACTTAG | CCBE1 | ENSG00000183287 | -0.32009396436001514 | [73,465] | [65,28] | -1 | dCas9-VP64 | positive selection | 2454564 | 59625378 | 59625401 | 18 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GGAGCGCAGTGGCGCGATCTTGG | CCBE1 | ENSG00000183287 | -1.763356426520778 | [237,164] | [17,19] | -9 | dCas9-VP64 | positive selection | 2493947 | 59601059 | 59601082 | 18 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TCTCACTCTGTCTCCCAGGCTGG | CCBE1 | ENSG00000183287 | -0.22012594312438807 | [153,72] | [52,11] | -2 | dCas9-VP64 | positive selection | 2513948 | 59442651 | 59442674 | 18 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TCACTGCAATCTCTGCCTCCCAG | CCBE1 | ENSG00000183287 | 0.1118552473866502 | [131,312] | [53,99] | 0 | dCas9-VP64 | positive selection | 2521157 | 59691443 | 59691466 | 18 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TTGCCCAGGCTGGAGTGCAGTGG | CCBE1 | ENSG00000183287 | -0.1814090993543942 | [50,40] | [18,6] | -2 | dCas9-VP64 | positive selection | 2531233 | 59614275 | 59614298 | 18 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAGGCATGAGCCATCGTGCCTGG | CCBE1 | ENSG00000183287 | 0.42142368151358683 | [69,54] | [32,21] | 3 | dCas9-VP64 | positive selection | 2535581 | 59625386 | 59625409 | 18 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GCGCCACTGCGCTCCAGCCTGGG | CCBE1 | ENSG00000183287 | 0.15562510186866851 | [37,63] | [19,15] | 1 | dCas9-VP64 | positive selection | 2536242 | 59450606 | 59450629 | 18 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TCACTACAACCTCTGCCTCCCAG | CCBE1 | ENSG00000183287 | 2.2699980135687987 | [309,268] | [879,61] | 8 | dCas9-VP64 | positive selection | 2539252 | 59589763 | 59589786 | 18 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GGAGTCTCGCTCTGTCGCCCTGG | CCBE1 | ENSG00000183287 | 0.35722745049512583 | [51,32] | [17,15] | 3 | dCas9-VP64 | positive selection | 2539545 | 59569758 | 59569781 | 18 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CACCTGTAATCTCAGCTACTTAG | CCBE1 | ENSG00000183287 | -0.35714226545986627 | [161,80] | [51,10] | -4 | dCas9-VP64 | positive selection | 2549819 | 59469587 | 59469610 | 18 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.3906913372111662 | [3,3] | [4,3] | 7 | hSpCas9 | positive selection | 2976673 | 59466800 | 59466823 | 18 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | AGCCTTCCCGGCACTCGCAGCGG | CCBE1 | ENSG00000183287 | 0.37473539952172513 | [3,3] | [4,3] | 7 | hSpCas9 | positive selection | 2976674 | 59466763 | 59466786 | 18 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | 0.2883650068717941 | [3,2] | [2,3] | 6 | hSpCas9 | positive selection | 2976675 | 59469587 | 59469610 | 18 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.4359123318024128 | [3,3] | [2,0] | -6 | hSpCas9 | positive selection | 3044531 | 59466800 | 59466823 | 18 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | AGCCTTCCCGGCACTCGCAGCGG | CCBE1 | ENSG00000183287 | 0.4303654946737812 | [3,3] | [2,3] | 7 | hSpCas9 | positive selection | 3044532 | 59466763 | 59466786 | 18 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.46687774771019436 | [3,3] | [3,0] | -6 | hSpCas9 | positive selection | 3044533 | 59469587 | 59469610 | 18 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.9006944397027659 | [73,89] | [0,0] | 4 | hSpCas9 | positive selection | 3341282 | 59469473 | 59469496 | 18 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.4499712893882311 | [111,111] | [0,0] | 2 | hSpCas9 | positive selection | 3360526 | 59469587 | 59469610 | 18 | - | 26780180 | HT29 | viability (Avana library 4 designs) | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.224372160666488 | [] | [] | 0 | hSpCas9 | negative selection | 3412943 | 59466799 | 59466822 | 18 | + | 26780180 | HT29 | viability (Avana library 4 designs) | AGCCTTCCCGGCACTCGCAGCGG | CCBE1 | ENSG00000183287 | 0.670764739696685 | [] | [] | 2 | hSpCas9 | negative selection | 3412944 | 59466763 | 59466786 | 18 | - | 26780180 | HT29 | viability (Avana library 4 designs) | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | 1.21672631782053 | [] | [] | 5 | hSpCas9 | negative selection | 3412945 | 59466763 | 59466786 | 18 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.100379149519023 | [] | [] | 0 | hSpCas9 | negative selection | 3488737 | 59469587 | 59469610 | 18 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 4.18011034515854 | [] | [] | 7 | hSpCas9 | negative selection | 3488738 | 59466799 | 59466822 | 18 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | AGCCTTCCCGGCACTCGCAGCGG | CCBE1 | ENSG00000183287 | 3.79452781717147 | [] | [] | 6 | hSpCas9 | negative selection | 3488739 | 59466779 | 59466802 | 18 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTACATCCGGGAAGATGATGGG | CCBE1 | ENSG00000183287 | 1.97375999841129 | [] | [] | 3 | hSpCas9 | negative selection | 3488740 | 59469498 | 59469521 | 18 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 4.01800339726059 | [] | [] | 6 | hSpCas9 | negative selection | 3488741 | 59466763 | 59466786 | 18 | - | 26780180 | A375 | viability (Avana lentiGuide) | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.409639190430282 | [] | [] | 0 | hSpCas9 | negative selection | 3597396 | 59469587 | 59469610 | 18 | - | 26780180 | A375 | viability (Avana lentiGuide) | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -1.08979342882029 | [] | [] | -2 | hSpCas9 | negative selection | 3597397 | 59466799 | 59466822 | 18 | + | 26780180 | A375 | viability (Avana lentiGuide) | AGCCTTCCCGGCACTCGCAGCGG | CCBE1 | ENSG00000183287 | 1.73425892484311 | [] | [] | 2 | hSpCas9 | negative selection | 3597398 | 59466779 | 59466802 | 18 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCTACATCCGGGAAGATGATGGG | CCBE1 | ENSG00000183287 | -2.79523845481105 | [] | [] | -5 | hSpCas9 | negative selection | 3597399 | 59469498 | 59469521 | 18 | - | 26780180 | A375 | viability (Avana lentiGuide) | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -3.82193807529315 | [] | [] | -6 | hSpCas9 | negative selection | 3597400 | 59466763 | 59466786 | 18 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | 0.14673611622985444 | [5] | [6,5] | 4 | hSpCas9 | positive selection | 3706055 | 59469587 | 59469610 | 18 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.03714589645579024 | [5] | [6,3] | 0 | hSpCas9 | positive selection | 3706056 | 59466799 | 59466822 | 18 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | AGCCTTCCCGGCACTCGCAGCGG | CCBE1 | ENSG00000183287 | 0.013275652062233068 | [4] | [5,3] | 0 | hSpCas9 | positive selection | 3706057 | 59466779 | 59466802 | 18 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTACATCCGGGAAGATGATGGG | CCBE1 | ENSG00000183287 | 0.24551416200192788 | [5] | [6,5] | 7 | hSpCas9 | positive selection | 3706058 | 59469498 | 59469521 | 18 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.34430746667429324 | [4] | [5,5] | 8 | hSpCas9 | positive selection | 3706059 | 59466763 | 59466786 | 18 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | 0.3865788788289676 | [4] | [5,4] | 9 | hSpCas9 | positive selection | 3814662 | 59469587 | 59469610 | 18 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.21891273643670725 | [5] | [4,3] | -3 | hSpCas9 | positive selection | 3814663 | 59466799 | 59466822 | 18 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | AGCCTTCCCGGCACTCGCAGCGG | CCBE1 | ENSG00000183287 | 0.03690044769115869 | [5] | [3,5] | 0 | hSpCas9 | positive selection | 3814664 | 59466779 | 59466802 | 18 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTACATCCGGGAAGATGATGGG | CCBE1 | ENSG00000183287 | 0.28133786358947555 | [5] | [6,5] | 7 | hSpCas9 | positive selection | 3814665 | 59469498 | 59469521 | 18 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.40990325231162605 | [5] | [4,1] | -5 | hSpCas9 | positive selection | 3814666 | 59469587 | 59469610 | 18 | - | 26780180 | A375 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 1.35796193852562 | [] | [] | 7 | hSpCas9 | negative selection | 3922846 | 59469473 | 59469496 | 18 | - | 26780180 | A375 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.877480533285375 | [] | [] | 3 | hSpCas9 | negative selection | 3922847 | 59469587 | 59469610 | 18 | - | 26780180 | HT29 | viability (GeCKOv2 library) | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 1.23751871704838 | [] | [] | 6 | hSpCas9 | negative selection | 4030812 | 59469473 | 59469496 | 18 | - | 26780180 | HT29 | viability (GeCKOv2 library) | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 1.35545757271637 | [] | [] | 7 | hSpCas9 | negative selection | 4030813 | 59469587 | 59469610 | 18 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.57402386307892 | [2] | [1,0] | -8 | hSpCas9 | positive selection | 4261192 | 59469473 | 59469496 | 18 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | -0.18262269058006003 | [2] | [2,0] | -4 | hSpCas9 | positive selection | 4325471 | 59466762 | 59466784 | 18 | - | 27760321 | OCIAML3 | viability | ATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | -0.8994374905149671 | [3,0] | [0,0] | -7 | hSpCas9 | negative selection | 4386077 | 59466791 | 59466813 | 18 | - | 27760321 | OCIAML3 | viability | GTGCCGGGAAGGCTACATCCGG | CCBE1 | ENSG00000183287 | -0.01908370005593052 | [323,277] | [238,221] | 0 | hSpCas9 | negative selection | 4386078 | 59469510 | 59469532 | 18 | - | 27760321 | OCIAML3 | viability | TCCGGGATACCGATATGACCGG | CCBE1 | ENSG00000183287 | -0.8087989391504334 | [331,258] | [173,74] | -6 | hSpCas9 | negative selection | 4386079 | 59466762 | 59466784 | 18 | - | 27760321 | OCIAML2 | viability | ATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | -0.9481828557800158 | [3,0] | [0,0] | -7 | hSpCas9 | negative selection | 4469540 | 59466791 | 59466813 | 18 | - | 27760321 | OCIAML2 | viability | GTGCCGGGAAGGCTACATCCGG | CCBE1 | ENSG00000183287 | 0.19678526903272753 | [323,277] | [241,325] | 2 | hSpCas9 | negative selection | 4469541 | 59469510 | 59469532 | 18 | - | 27760321 | OCIAML2 | viability | TCCGGGATACCGATATGACCGG | CCBE1 | ENSG00000183287 | 0.307886974588547 | [331,258] | [226,381] | 4 | hSpCas9 | negative selection | 4469542 | 59466762 | 59466784 | 18 | - | 27760321 | MV411 | viability | ATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | -0.6543589216002852 | [3,0] | [0,0] | -4 | hSpCas9 | negative selection | 4553003 | 59466791 | 59466813 | 18 | - | 27760321 | MV411 | viability | GTGCCGGGAAGGCTACATCCGG | CCBE1 | ENSG00000183287 | 1.583216854958688 | [323,277] | [823,246] | 9 | hSpCas9 | negative selection | 4553004 | 59469510 | 59469532 | 18 | - | 27760321 | MV411 | viability | TCCGGGATACCGATATGACCGG | CCBE1 | ENSG00000183287 | -0.19896919125681756 | [331,258] | [65,322] | -1 | hSpCas9 | negative selection | 4553005 | 59466762 | 59466784 | 18 | - | 27760321 | HL60 | viability | ATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | -0.9622290833944218 | [3,0] | [0,0] | -7 | hSpCas9 | negative selection | 4636466 | 59466791 | 59466813 | 18 | - | 27760321 | HL60 | viability | GTGCCGGGAAGGCTACATCCGG | CCBE1 | ENSG00000183287 | -0.5502151422265859 | [323,277] | [147,187] | -5 | hSpCas9 | negative selection | 4636467 | 59469510 | 59469532 | 18 | - | 27760321 | HL60 | viability | TCCGGGATACCGATATGACCGG | CCBE1 | ENSG00000183287 | -0.8494093950068923 | [331,258] | [167,95] | -7 | hSpCas9 | negative selection | 4636468 | 59466762 | 59466784 | 18 | - | 27760321 | HT1080 | viability | ATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 1.3056276939190559 | [0,0] | [0,0] | 7 | hSpCas9 | negative selection | 4719929 | 59466791 | 59466813 | 18 | - | 27760321 | HT1080 | viability | GTGCCGGGAAGGCTACATCCGG | CCBE1 | ENSG00000183287 | -0.3292760183993316 | [277,216] | [77,78] | -1 | hSpCas9 | negative selection | 4719930 | 59469510 | 59469532 | 18 | - | 27760321 | HT1080 | viability | TCCGGGATACCGATATGACCGG | CCBE1 | ENSG00000183287 | 0.41077599363646317 | [258,201] | [133,108] | 2 | hSpCas9 | negative selection | 4719931 | 59466762 | 59466784 | 18 | - | 27760321 | HT29 | viability after 7 days | ATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 1.6039964213764337 | [0,0] | [10,0,0] | 9 | hSpCas9 | negative selection | 4803392 | 59466791 | 59466813 | 18 | - | 27760321 | HT29 | viability after 7 days | GTGCCGGGAAGGCTACATCCGG | CCBE1 | ENSG00000183287 | 0.576702522696175 | [277,216] | [501,576,351] | 8 | hSpCas9 | negative selection | 4803393 | 59469510 | 59469532 | 18 | - | 27760321 | HT29 | viability after 7 days | TCCGGGATACCGATATGACCGG | CCBE1 | ENSG00000183287 | 0.2879901298719598 | [258,201] | [384,333,368] | 4 | hSpCas9 | negative selection | 4803394 | 59466762 | 59466784 | 18 | - | 27760321 | HT29 | viability after 25 days | ATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 2.8852826245147725 | [0,0] | [0,0,25] | 9 | hSpCas9 | negative selection | 4886855 | 59466791 | 59466813 | 18 | - | 27760321 | HT29 | viability after 25 days | GTGCCGGGAAGGCTACATCCGG | CCBE1 | ENSG00000183287 | 0.5924975988396696 | [277,216] | [458,380,437] | 6 | hSpCas9 | negative selection | 4886856 | 59469510 | 59469532 | 18 | - | 27760321 | HT29 | viability after 25 days | TCCGGGATACCGATATGACCGG | CCBE1 | ENSG00000183287 | -0.026654554234815886 | [258,201] | [198,313,266] | 0 | hSpCas9 | negative selection | 4886857 | 59466762 | 59466784 | 18 | - | 27760321 | HT29 | viability after 22 days | ATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 3.8352478561427503 | [0,0] | [0,0,48] | 9 | hSpCas9 | negative selection | 4970318 | 59466791 | 59466813 | 18 | - | 27760321 | HT29 | viability after 22 days | GTGCCGGGAAGGCTACATCCGG | CCBE1 | ENSG00000183287 | 0.7352264153389831 | [277,216] | [633,378,410] | 8 | hSpCas9 | negative selection | 4970319 | 59469510 | 59469532 | 18 | - | 27760321 | HT29 | viability after 22 days | TCCGGGATACCGATATGACCGG | CCBE1 | ENSG00000183287 | 0.053992643818619235 | [258,201] | [279,351,196] | 0 | hSpCas9 | negative selection | 4970320 | 59466762 | 59466784 | 18 | - | 27760321 | HT29 | viability after 19 days | ATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | -0.21553315036351428 | [0,0] | [0,0,0] | -2 | hSpCas9 | negative selection | 5053781 | 59466791 | 59466813 | 18 | - | 27760321 | HT29 | viability after 19 days | GTGCCGGGAAGGCTACATCCGG | CCBE1 | ENSG00000183287 | 0.5783506823039515 | [277,216] | [362,517,381] | 6 | hSpCas9 | negative selection | 5053782 | 59469510 | 59469532 | 18 | - | 27760321 | HT29 | viability after 19 days | TCCGGGATACCGATATGACCGG | CCBE1 | ENSG00000183287 | -0.41152593521814307 | [258,201] | [310,197,100] | -4 | hSpCas9 | negative selection | 5053783 | 59466762 | 59466784 | 18 | - | 27760321 | HT29 | viability after 16 days | ATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 0.5099320058880714 | [0,0] | [2,0,0] | 6 | hSpCas9 | negative selection | 5137244 | 59466791 | 59466813 | 18 | - | 27760321 | HT29 | viability after 16 days | GTGCCGGGAAGGCTACATCCGG | CCBE1 | ENSG00000183287 | 0.39138357497176723 | [277,216] | [452,402,240] | 4 | hSpCas9 | negative selection | 5137245 | 59469510 | 59469532 | 18 | - | 27760321 | HT29 | viability after 16 days | TCCGGGATACCGATATGACCGG | CCBE1 | ENSG00000183287 | 0.10776894038273044 | [258,201] | [317,291,226] | 1 | hSpCas9 | negative selection | 5137246 | 59466762 | 59466784 | 18 | - | 27760321 | HT29 | viability after 13 days | ATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 2.8131741604529674 | [0,0] | [0,0,21] | 9 | hSpCas9 | negative selection | 5220707 | 59466791 | 59466813 | 18 | - | 27760321 | HT29 | viability after 13 days | GTGCCGGGAAGGCTACATCCGG | CCBE1 | ENSG00000183287 | 0.8749224120473358 | [277,216] | [632,515,435] | 9 | hSpCas9 | negative selection | 5220708 | 59469510 | 59469532 | 18 | - | 27760321 | HT29 | viability after 13 days | TCCGGGATACCGATATGACCGG | CCBE1 | ENSG00000183287 | 0.04573145651676058 | [258,201] | [334,287,208] | 0 | hSpCas9 | negative selection | 5220709 | 59466762 | 59466784 | 18 | - | 27760321 | HT29 | viability after 10 days | ATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 3.8872862439957068 | [0,0] | [0,0,52] | 9 | hSpCas9 | negative selection | 5304170 | 59466791 | 59466813 | 18 | - | 27760321 | HT29 | viability after 10 days | GTGCCGGGAAGGCTACATCCGG | CCBE1 | ENSG00000183287 | 0.5154986292851755 | [277,216] | [516,364,440] | 7 | hSpCas9 | negative selection | 5304171 | 59469510 | 59469532 | 18 | - | 27760321 | HT29 | viability after 10 days | TCCGGGATACCGATATGACCGG | CCBE1 | ENSG00000183287 | 0.05324385982388624 | [258,201] | [237,430,231] | 0 | hSpCas9 | negative selection | 5304172 | 59466762 | 59466784 | 18 | - | 27760321 | MOLM13 | viability | ATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | -0.4283021087726899 | [3,0] | [0,0] | -3 | hSpCas9 | negative selection | 5387633 | 59466791 | 59466813 | 18 | - | 27760321 | MOLM13 | viability | GTGCCGGGAAGGCTACATCCGG | CCBE1 | ENSG00000183287 | 1.5389539107163528 | [323,277] | [955,96] | 9 | hSpCas9 | negative selection | 5387634 | 59469510 | 59469532 | 18 | - | 27760321 | MOLM13 | viability | TCCGGGATACCGATATGACCGG | CCBE1 | ENSG00000183287 | -0.7987268145754073 | [331,258] | [85,102] | -5 | hSpCas9 | negative selection | 5387635 | 59469587 | 59469610 | 18 | - | 27260156 | BXPC3 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.11764991720378348 | [256] | [276,183,207,329] | -3 | hSpCas9 | negative selection | 5533652 | 59469473 | 59469496 | 18 | - | 27260156 | BXPC3 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.09927862724786185 | [213] | [205,215,237,310] | 2 | hSpCas9 | negative selection | 5597931 | 59469587 | 59469610 | 18 | - | 27260156 | A673 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.04644532706145432 | [256] | [420,165,358,344] | 1 | hSpCas9 | negative selection | 5654903 | 59469473 | 59469496 | 18 | - | 27260156 | A673 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.17102796493494932 | [213] | [337,292,264,264] | 4 | hSpCas9 | negative selection | 5719182 | 59469587 | 59469610 | 18 | - | 27260156 | A375 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.3919635434983112 | [256] | [161,378,168,224] | -5 | hSpCas9 | negative selection | 5776154 | 59469473 | 59469496 | 18 | - | 27260156 | A375 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.43414039303088714 | [213] | [314,471,353,238] | 6 | hSpCas9 | negative selection | 5840433 | 59469587 | 59469610 | 18 | - | 27260156 | COLO741 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.0745724846078516 | [256] | [348,278,309] | -2 | hSpCas9 | negative selection | 5897405 | 59469473 | 59469496 | 18 | - | 27260156 | COLO741 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | -0.46267392451860756 | [213] | [141,247,199] | -7 | hSpCas9 | negative selection | 5961684 | 59469587 | 59469610 | 18 | - | 27260156 | CAL120 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.634256067803222 | [256] | [288,161,179] | -7 | hSpCas9 | negative selection | 6018656 | 59469473 | 59469496 | 18 | - | 27260156 | CAL120 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.21383353014248385 | [213] | [369,166,396] | 3 | hSpCas9 | negative selection | 6082935 | 59469587 | 59469610 | 18 | - | 27260156 | CADOES1 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.05358963157975427 | [256] | [188,180,300,250] | -1 | hSpCas9 | negative selection | 6139907 | 59469473 | 59469496 | 18 | - | 27260156 | CADOES1 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | -0.02029261649206271 | [213] | [228,147,257,147] | 0 | hSpCas9 | negative selection | 6204186 | 59469587 | 59469610 | 18 | - | 27260156 | EWS502 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.10313677717659564 | [256] | [166,192,364,305] | -2 | hSpCas9 | negative selection | 6261158 | 59469473 | 59469496 | 18 | - | 27260156 | EWS502 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.15814856012176515 | [213] | [250,230,247,283] | 2 | hSpCas9 | negative selection | 6325437 | 59469587 | 59469610 | 18 | - | 27260156 | EW8 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.0812735086315931 | [256] | [258,155,181,293] | 1 | hSpCas9 | negative selection | 6382409 | 59469473 | 59469496 | 18 | - | 27260156 | EW8 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | -0.025298699885163645 | [213] | [256,169,139,128] | 0 | hSpCas9 | negative selection | 6446688 | 59469587 | 59469610 | 18 | - | 27260156 | CORL105 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.4004794802437376 | [256] | [211,182,216,297] | -6 | hSpCas9 | negative selection | 6503660 | 59469473 | 59469496 | 18 | - | 27260156 | CORL105 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.06033314260888578 | [213] | [238,278,281,246] | 1 | hSpCas9 | negative selection | 6567939 | 59469587 | 59469610 | 18 | - | 27260156 | HS294T | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.03133601876973746 | [256] | [65,122,100,121] | 0 | hSpCas9 | negative selection | 6624911 | 59469473 | 59469496 | 18 | - | 27260156 | HS294T | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.24212950515005105 | [213] | [75,134,47,139] | 3 | hSpCas9 | negative selection | 6689190 | 59469587 | 59469610 | 18 | - | 27260156 | HCC44 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.07225235513939188 | [256] | [471,194,276,191] | -1 | hSpCas9 | negative selection | 6746162 | 59469473 | 59469496 | 18 | - | 27260156 | HCC44 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.5890852387306316 | [213] | [350,426,337,323] | 8 | hSpCas9 | negative selection | 6810441 | 59469587 | 59469610 | 18 | - | 27260156 | G402 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.49926325020057594 | [256] | [392,237,75,205] | -6 | hSpCas9 | negative selection | 6867413 | 59469473 | 59469496 | 18 | - | 27260156 | G402 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | -0.03028512845902087 | [213] | [206,377,204,232] | 0 | hSpCas9 | negative selection | 6931692 | 59469587 | 59469610 | 18 | - | 27260156 | L33 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.2338004675526194 | [256] | [289,101,193,360] | 5 | hSpCas9 | negative selection | 6988664 | 59469473 | 59469496 | 18 | - | 27260156 | L33 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.008836609198189072 | [213] | [228,92,154,158] | 0 | hSpCas9 | negative selection | 7052943 | 59469587 | 59469610 | 18 | - | 27260156 | K562 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.4817964367227169 | [256] | [269,184,105,107] | -5 | hSpCas9 | negative selection | 7109915 | 59469473 | 59469496 | 18 | - | 27260156 | K562 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.7460213832006584 | [213] | [375,436,136,331] | 8 | hSpCas9 | negative selection | 7174194 | 59469587 | 59469610 | 18 | - | 27260156 | HT29 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.08375692556275993 | [256] | [304,376,320,321] | 1 | hSpCas9 | negative selection | 7231166 | 59469473 | 59469496 | 18 | - | 27260156 | HT29 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.19641498090094844 | [213] | [352,330,329,195] | 4 | hSpCas9 | negative selection | 7295445 | 59469587 | 59469610 | 18 | - | 27260156 | MHHES1 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.12663469242646774 | [256] | [370,237,403,256] | 2 | hSpCas9 | negative selection | 7352417 | 59469473 | 59469496 | 18 | - | 27260156 | MHHES1 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.5511914362344522 | [213] | [536,295,435,190] | 8 | hSpCas9 | negative selection | 7416696 | 59469587 | 59469610 | 18 | - | 27260156 | MEWO | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.1651424264159853 | [256] | [222,209,366] | 3 | hSpCas9 | negative selection | 7473668 | 59469473 | 59469496 | 18 | - | 27260156 | MEWO | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.4404933899577299 | [213] | [356,181,292] | 8 | hSpCas9 | negative selection | 7537947 | 59469587 | 59469610 | 18 | - | 27260156 | LNCAPCLONEFGC | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.40564938520756055 | [256] | [148,156,238,168] | -6 | hSpCas9 | negative selection | 7594919 | 59469473 | 59469496 | 18 | - | 27260156 | LNCAPCLONEFGC | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.1559090409288867 | [213] | [230,145,275,223] | 2 | hSpCas9 | negative selection | 7659198 | 59469587 | 59469610 | 18 | - | 27260156 | PANC0327 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.2758586634170147 | [256] | [141,226,379,351] | 4 | hSpCas9 | negative selection | 7716170 | 59469473 | 59469496 | 18 | - | 27260156 | PANC0327 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | -0.27214150302526985 | [213] | [207,132,183,111] | -4 | hSpCas9 | negative selection | 7780449 | 59469587 | 59469610 | 18 | - | 27260156 | NCIH2009 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.4497883007665455 | [256] | [449,350,663] | 6 | hSpCas9 | negative selection | 7837421 | 59469473 | 59469496 | 18 | - | 27260156 | NCIH2009 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | -0.2380560508493923 | [213] | [287,193,285] | -3 | hSpCas9 | negative selection | 7901700 | 59469587 | 59469610 | 18 | - | 27260156 | NCIH1373 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.5219024188233797 | [256] | [379,502,452,76] | 5 | hSpCas9 | negative selection | 7958672 | 59469473 | 59469496 | 18 | - | 27260156 | NCIH1373 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | -0.22467217341544932 | [213] | [344,173,223,24] | -2 | hSpCas9 | negative selection | 8022951 | 59469587 | 59469610 | 18 | - | 27260156 | PATU8902 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.2270185432710865 | [256] | [191,722,348,431] | 2 | hSpCas9 | negative selection | 8079923 | 59469473 | 59469496 | 18 | - | 27260156 | PATU8902 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.46853860811868775 | [213] | [425,355,289,631] | 5 | hSpCas9 | negative selection | 8144202 | 59469587 | 59469610 | 18 | - | 27260156 | PANC1 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.17156897374820357 | [256] | [226,248,259,253] | 2 | hSpCas9 | negative selection | 8201174 | 59469473 | 59469496 | 18 | - | 27260156 | PANC1 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | -0.009490628417131886 | [213] | [157,249,246,100] | 0 | hSpCas9 | negative selection | 8265453 | 59469587 | 59469610 | 18 | - | 27260156 | PANC0813 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.5521593085575963 | [256] | [454,273,516,520] | 8 | hSpCas9 | negative selection | 8322425 | 59469473 | 59469496 | 18 | - | 27260156 | PANC0813 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.49827206041305105 | [213] | [371,235,495,319] | 7 | hSpCas9 | negative selection | 8386704 | 59469587 | 59469610 | 18 | - | 27260156 | RDES | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.05138233745501075 | [256] | [160,358,388,240] | -1 | hSpCas9 | negative selection | 8443676 | 59469473 | 59469496 | 18 | - | 27260156 | RDES | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.13637791454448622 | [213] | [280,251,259,279] | 2 | hSpCas9 | negative selection | 8507955 | 59469587 | 59469610 | 18 | - | 27260156 | PC3 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.39032493806382595 | [256] | [108,210,254,251] | -7 | hSpCas9 | negative selection | 8564927 | 59469473 | 59469496 | 18 | - | 27260156 | PC3 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.3928574827787523 | [213] | [131,491,353,196] | 8 | hSpCas9 | negative selection | 8629206 | 59469587 | 59469610 | 18 | - | 27260156 | PATU8988T | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.2108564717044047 | [256] | [240,287,155,177] | -4 | hSpCas9 | negative selection | 8686178 | 59469473 | 59469496 | 18 | - | 27260156 | PATU8988T | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.24983881678774156 | [213] | [178,166,188,458] | 4 | hSpCas9 | negative selection | 8750457 | 59469587 | 59469610 | 18 | - | 27260156 | T47D | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | -0.125450385918629 | [256] | [279,273,287,254] | -3 | hSpCas9 | negative selection | 8807429 | 59469473 | 59469496 | 18 | - | 27260156 | T47D | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.12926565338992257 | [213] | [236,355,259,228] | 2 | hSpCas9 | negative selection | 8871708 | 59469587 | 59469610 | 18 | - | 27260156 | SU8686 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.5323130775075673 | [256] | [307,328,433,422] | 8 | hSpCas9 | negative selection | 8928680 | 59469473 | 59469496 | 18 | - | 27260156 | SU8686 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.5912870386463875 | [213] | [206,308,348,446] | 8 | hSpCas9 | negative selection | 8992959 | 59469587 | 59469610 | 18 | - | 27260156 | SKES1 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.023515023848716177 | [256] | [272,372,177,234] | 0 | hSpCas9 | negative selection | 9049931 | 59469473 | 59469496 | 18 | - | 27260156 | SKES1 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | -0.17030171962808138 | [213] | [200,139,200,207] | -4 | hSpCas9 | negative selection | 9114210 | 59469587 | 59469610 | 18 | - | 27260156 | TOV112D | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.1578571875176985 | [256] | [281,254,285,315] | 3 | hSpCas9 | negative selection | 9171182 | 59469473 | 59469496 | 18 | - | 27260156 | TOV112D | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.3239672148773797 | [213] | [162,509,241,209] | 6 | hSpCas9 | negative selection | 9235461 | 59469587 | 59469610 | 18 | - | 27260156 | TC71 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.16999883277427486 | [256] | [361,259,223,400] | 4 | hSpCas9 | negative selection | 9292433 | 59469473 | 59469496 | 18 | - | 27260156 | TC71 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.026436136419233813 | [213] | [309,162,226,232] | 0 | hSpCas9 | negative selection | 9356712 | 59469587 | 59469610 | 18 | - | 27260156 | TC32 | viability | AGATTACGACGTTTGTGCCGAGG | CCBE1 | ENSG00000183287 | 0.3675913798161655 | [256] | [319,203,367,389] | 6 | hSpCas9 | negative selection | 9413684 | 59469473 | 59469496 | 18 | - | 27260156 | TC32 | viability | GCGGGAGAAGCCATACTGTCTGG | CCBE1 | ENSG00000183287 | 0.20547602336250048 | [213] | [261,174,211,280] | 4 | hSpCas9 | negative selection | 9477963 | 59454850 | 59454873 | 18 | - | 27869803 | HPAFII | viability after 27 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.9058308709852483 | [1202] | [1070,1279,NaN] | 7 | hSpCas9 | negative selection | 9564861 | 59466763 | 59466786 | 18 | - | 27869803 | HPAFII | viability after 27 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | 0.6973083759341775 | [394] | [405,278,NaN] | 5 | hSpCas9 | negative selection | 9564862 | 59469498 | 59469521 | 18 | - | 27869803 | HPAFII | viability after 27 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.23368358210138318 | [84] | [87,22,NaN] | 1 | hSpCas9 | negative selection | 9564863 | 59480185 | 59480208 | 18 | - | 27869803 | HPAFII | viability after 27 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 0.5077737109489877 | [201] | [222,90,NaN] | 4 | hSpCas9 | negative selection | 9564864 | 59454850 | 59454873 | 18 | - | 27869803 | HPAFII | viability after 15 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.6106479297307525 | [1202] | [2887,1405,NaN] | 7 | hSpCas9 | negative selection | 9647310 | 59466763 | 59466786 | 18 | - | 27869803 | HPAFII | viability after 15 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | 0.12300904181890837 | [394] | [658,339,NaN] | 1 | hSpCas9 | negative selection | 9647311 | 59469498 | 59469521 | 18 | - | 27869803 | HPAFII | viability after 15 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.8780989607558449 | [84] | [82,28,NaN] | -7 | hSpCas9 | negative selection | 9647312 | 59480185 | 59480208 | 18 | - | 27869803 | HPAFII | viability after 15 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 0.02126949954687235 | [201] | [252,199,NaN] | 0 | hSpCas9 | negative selection | 9647313 | 59454850 | 59454873 | 18 | - | 27869803 | ASPC1 | viability after 36 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.12023977591789592 | [2711] | [1279,1416,533] | 1 | hSpCas9 | negative selection | 9729759 | 59466763 | 59466786 | 18 | - | 27869803 | ASPC1 | viability after 36 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | -0.4231589477643627 | [1086] | [324,425,136] | -4 | hSpCas9 | negative selection | 9729760 | 59469498 | 59469521 | 18 | - | 27869803 | ASPC1 | viability after 36 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.12771116186817633 | [173] | [135,10,33] | -1 | hSpCas9 | negative selection | 9729761 | 59480185 | 59480208 | 18 | - | 27869803 | ASPC1 | viability after 36 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 0.8859387037853896 | [491] | [378,233,336] | 8 | hSpCas9 | negative selection | 9729762 | 59454850 | 59454873 | 18 | - | 27869803 | PATU8988S | viability after 35 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.8157749268783092 | [2120] | [1572,1433,NaN] | 8 | hSpCas9 | negative selection | 9812208 | 59466763 | 59466786 | 18 | - | 27869803 | PATU8988S | viability after 35 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | 0.5436721239027635 | [801] | [399,541,NaN] | 6 | hSpCas9 | negative selection | 9812209 | 59469498 | 59469521 | 18 | - | 27869803 | PATU8988S | viability after 35 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 1.8498627332286341 | [208] | [268,337,NaN] | 9 | hSpCas9 | negative selection | 9812210 | 59480185 | 59480208 | 18 | - | 27869803 | PATU8988S | viability after 35 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 1.257772705025034 | [361] | [188,508,NaN] | 9 | hSpCas9 | negative selection | 9812211 | 59454850 | 59454873 | 18 | - | 27869803 | PATU8988S | viability after 31 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.698661000568255 | [2120] | [1303,1459,NaN] | 7 | hSpCas9 | negative selection | 9894657 | 59466763 | 59466786 | 18 | - | 27869803 | PATU8988S | viability after 31 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | 0.3252347848750695 | [801] | [291,538,NaN] | 4 | hSpCas9 | negative selection | 9894658 | 59469498 | 59469521 | 18 | - | 27869803 | PATU8988S | viability after 31 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 1.6372041295352537 | [208] | [216,312,NaN] | 9 | hSpCas9 | negative selection | 9894659 | 59480185 | 59480208 | 18 | - | 27869803 | PATU8988S | viability after 31 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 0.983756240894851 | [361] | [178,420,NaN] | 9 | hSpCas9 | negative selection | 9894660 | 59454850 | 59454873 | 18 | - | 27869803 | HPAFII | viability after 35 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.9791039388879974 | [1202] | [573,1905,NaN] | 6 | hSpCas9 | negative selection | 9977106 | 59466763 | 59466786 | 18 | - | 27869803 | HPAFII | viability after 35 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | 1.0441115302760196 | [394] | [528,280,NaN] | 7 | hSpCas9 | negative selection | 9977107 | 59469498 | 59469521 | 18 | - | 27869803 | HPAFII | viability after 35 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 1.1196225702849874 | [84] | [156,21,NaN] | 7 | hSpCas9 | negative selection | 9977108 | 59480185 | 59480208 | 18 | - | 27869803 | HPAFII | viability after 35 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 0.4532008177001724 | [201] | [147,130,NaN] | 3 | hSpCas9 | negative selection | 9977109 | 59454850 | 59454873 | 18 | - | 27869803 | HPAFII | viability after 31 days | CGTGCTGCAGCTGAAGCAAAAGG | CCBE1 | ENSG00000183287 | 0.7579452440756369 | [1202] | [833,1476,NaN] | 5 | hSpCas9 | negative selection | 10059555 | 59466763 | 59466786 | 18 | - | 27869803 | HPAFII | viability after 31 days | TGATGGGAAGACATGTACCAGGG | CCBE1 | ENSG00000183287 | 0.6236153385812088 | [394] | [431,242,NaN] | 4 | hSpCas9 | negative selection | 10059556 | 59469498 | 59469521 | 18 | - | 27869803 | HPAFII | viability after 31 days | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.8096578099227718 | [84] | [141,19,NaN] | 6 | hSpCas9 | negative selection | 10059557 | 59480185 | 59480208 | 18 | - | 27869803 | HPAFII | viability after 31 days | CTTGGACAATGCATCCCAGAAGG | CCBE1 | ENSG00000183287 | 0.21086216845352806 | [201] | [146,113,NaN] | 1 | hSpCas9 | negative selection | 10059558 | 59439789 | 59439812 | 18 | - | 28162770 | P31FUJ | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | 1.0806143906174663 | [67] | [168] | 9 | hSpCas9 | negative selection | 10126752 | 59466762 | 59466785 | 18 | - | 28162770 | P31FUJ | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 0.46347731917093554 | [186] | [302] | 5 | hSpCas9 | negative selection | 10126753 | 59439763 | 59439786 | 18 | + | 28162770 | P31FUJ | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 0.8623550286259613 | [109] | [234] | 8 | hSpCas9 | negative selection | 10126754 | 59466864 | 59466887 | 18 | - | 28162770 | P31FUJ | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | -0.4146405274001916 | [227] | [200] | -4 | hSpCas9 | negative selection | 10126755 | 59439550 | 59439573 | 18 | - | 28162770 | P31FUJ | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | 0.7531682356815631 | [154] | [306] | 8 | hSpCas9 | negative selection | 10126756 | 59469498 | 59469521 | 18 | - | 28162770 | P31FUJ | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.3408576472412765 | [298] | [444] | 4 | hSpCas9 | negative selection | 10126757 | 59466806 | 59466829 | 18 | - | 28162770 | P31FUJ | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | 1.1698302739736846 | [72] | [192] | 9 | hSpCas9 | negative selection | 10126758 | 59439789 | 59439812 | 18 | - | 28162770 | TF1 | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | NaN | [NaN] | [138] | 1 | hSpCas9 | negative selection | 10296118 | 59466762 | 59466785 | 18 | - | 28162770 | TF1 | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | NaN | [NaN] | [218] | 1 | hSpCas9 | negative selection | 10296119 | 59439763 | 59439786 | 18 | + | 28162770 | TF1 | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | NaN | [NaN] | [89] | 1 | hSpCas9 | negative selection | 10296120 | 59466864 | 59466887 | 18 | - | 28162770 | TF1 | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | NaN | [NaN] | [273] | 1 | hSpCas9 | negative selection | 10296121 | 59439550 | 59439573 | 18 | - | 28162770 | TF1 | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | NaN | [NaN] | [69] | 1 | hSpCas9 | negative selection | 10296122 | 59469498 | 59469521 | 18 | - | 28162770 | TF1 | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | NaN | [NaN] | [434] | 1 | hSpCas9 | negative selection | 10296123 | 59466806 | 59466829 | 18 | - | 28162770 | TF1 | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | NaN | [NaN] | [163] | 1 | hSpCas9 | negative selection | 10296124 | 59439789 | 59439812 | 18 | - | 28162770 | SKM1 | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | -0.915111102413487 | [15] | [14] | -6 | hSpCas9 | negative selection | 10465484 | 59466762 | 59466785 | 18 | - | 28162770 | SKM1 | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 0.2168175508685227 | [54] | [112] | 2 | hSpCas9 | negative selection | 10465485 | 59439763 | 59439786 | 18 | + | 28162770 | SKM1 | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 0.04234320262042818 | [38] | [70] | 0 | hSpCas9 | negative selection | 10465486 | 59466864 | 59466887 | 18 | - | 28162770 | SKM1 | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | 0.2493829352147599 | [68] | [144] | 2 | hSpCas9 | negative selection | 10465487 | 59439550 | 59439573 | 18 | - | 28162770 | SKM1 | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | 1.4548385073368189 | [12] | [62] | 9 | hSpCas9 | negative selection | 10465488 | 59469498 | 59469521 | 18 | - | 28162770 | SKM1 | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.16109034406755068 | [73] | [116] | -1 | hSpCas9 | negative selection | 10465489 | 59466806 | 59466829 | 18 | - | 28162770 | SKM1 | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | -2.2005133212757353 | [25] | [9] | -8 | hSpCas9 | negative selection | 10465490 | 59439789 | 59439812 | 18 | - | 28162770 | SKM1 | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | -0.915111102413487 | [15] | [14] | -6 | hSpCas9 | negative selection | 10634850 | 59466762 | 59466785 | 18 | - | 28162770 | SKM1 | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 0.2168175508685227 | [54] | [112] | 2 | hSpCas9 | negative selection | 10634851 | 59439763 | 59439786 | 18 | + | 28162770 | SKM1 | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 0.04234320262042818 | [38] | [70] | 0 | hSpCas9 | negative selection | 10634852 | 59466864 | 59466887 | 18 | - | 28162770 | SKM1 | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | 0.2493829352147599 | [68] | [144] | 2 | hSpCas9 | negative selection | 10634853 | 59439550 | 59439573 | 18 | - | 28162770 | SKM1 | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | 1.4548385073368189 | [12] | [62] | 9 | hSpCas9 | negative selection | 10634854 | 59469498 | 59469521 | 18 | - | 28162770 | SKM1 | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.16109034406755068 | [73] | [116] | -1 | hSpCas9 | negative selection | 10634855 | 59466806 | 59466829 | 18 | - | 28162770 | SKM1 | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | -2.2005133212757353 | [25] | [9] | -8 | hSpCas9 | negative selection | 10634856 | 59439789 | 59439812 | 18 | - | 28162770 | PL21 | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | 0.6949043062388981 | [87] | [61] | 6 | hSpCas9 | negative selection | 10804216 | 59466762 | 59466785 | 18 | - | 28162770 | PL21 | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 0.11200870421065501 | [269] | [126] | 1 | hSpCas9 | negative selection | 10804217 | 59439763 | 59439786 | 18 | + | 28162770 | PL21 | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 1.509243669019099 | [112] | [139] | 9 | hSpCas9 | negative selection | 10804218 | 59466864 | 59466887 | 18 | - | 28162770 | PL21 | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | 0.47382126452262263 | [224] | [135] | 4 | hSpCas9 | negative selection | 10804219 | 59439550 | 59439573 | 18 | - | 28162770 | PL21 | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | -0.17331878103812415 | [113] | [43] | -1 | hSpCas9 | negative selection | 10804220 | 59469498 | 59469521 | 18 | - | 28162770 | PL21 | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.5676869433816466 | [251] | [73] | -4 | hSpCas9 | negative selection | 10804221 | 59466806 | 59466829 | 18 | - | 28162770 | PL21 | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | -0.20425064059001485 | [44] | [16] | -1 | hSpCas9 | negative selection | 10804222 | 59439789 | 59439812 | 18 | - | 28162770 | P31FUJ | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | 1.0806143906174663 | [67] | [168] | 9 | hSpCas9 | negative selection | 10973582 | 59466762 | 59466785 | 18 | - | 28162770 | P31FUJ | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 0.46347731917093554 | [186] | [302] | 5 | hSpCas9 | negative selection | 10973583 | 59439763 | 59439786 | 18 | + | 28162770 | P31FUJ | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 0.8623550286259613 | [109] | [234] | 8 | hSpCas9 | negative selection | 10973584 | 59466864 | 59466887 | 18 | - | 28162770 | P31FUJ | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | -0.4146405274001916 | [227] | [200] | -4 | hSpCas9 | negative selection | 10973585 | 59439550 | 59439573 | 18 | - | 28162770 | P31FUJ | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | 0.7531682356815631 | [154] | [306] | 8 | hSpCas9 | negative selection | 10973586 | 59469498 | 59469521 | 18 | - | 28162770 | P31FUJ | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.3408576472412765 | [298] | [444] | 4 | hSpCas9 | negative selection | 10973587 | 59466806 | 59466829 | 18 | - | 28162770 | P31FUJ | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | 1.1698302739736846 | [72] | [192] | 9 | hSpCas9 | negative selection | 10973588 | 59439789 | 59439812 | 18 | - | 28162770 | OCIAML5 | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | 0.7328959298571593 | [44] | [134] | 6 | hSpCas9 | negative selection | 11142948 | 59466762 | 59466785 | 18 | - | 28162770 | OCIAML5 | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 0.8189849065708683 | [102] | [327] | 7 | hSpCas9 | negative selection | 11142949 | 59439763 | 59439786 | 18 | + | 28162770 | OCIAML5 | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | -0.09764377962124438 | [114] | [193] | 0 | hSpCas9 | negative selection | 11142950 | 59466864 | 59466887 | 18 | - | 28162770 | OCIAML5 | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | 0.5837524905513498 | [111] | [302] | 5 | hSpCas9 | negative selection | 11142951 | 59439550 | 59439573 | 18 | - | 28162770 | OCIAML5 | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | 0.6033851968607552 | [65] | [180] | 5 | hSpCas9 | negative selection | 11142952 | 59469498 | 59469521 | 18 | - | 28162770 | OCIAML5 | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.1931626831290007 | [156] | [323] | 1 | hSpCas9 | negative selection | 11142953 | 59466806 | 59466829 | 18 | - | 28162770 | OCIAML5 | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | 1.8108984418584324 | [32] | [208] | 9 | hSpCas9 | negative selection | 11142954 | 59439789 | 59439812 | 18 | - | 28162770 | EOL1 | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | -0.49048972770830934 | [103] | [38] | -4 | hSpCas9 | negative selection | 11312314 | 59466762 | 59466785 | 18 | - | 28162770 | EOL1 | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 0.19574949827572702 | [410] | [247] | 1 | hSpCas9 | negative selection | 11312315 | 59439763 | 59439786 | 18 | + | 28162770 | EOL1 | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 0.45380083970540314 | [175] | [126] | 4 | hSpCas9 | negative selection | 11312316 | 59466864 | 59466887 | 18 | - | 28162770 | EOL1 | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | 0.8398665456470964 | [420] | [396] | 7 | hSpCas9 | negative selection | 11312317 | 59439550 | 59439573 | 18 | - | 28162770 | EOL1 | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | 0.48094112009491985 | [101] | [74] | 4 | hSpCas9 | negative selection | 11312318 | 59469498 | 59469521 | 18 | - | 28162770 | EOL1 | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.466342413135317 | [293] | [213] | 4 | hSpCas9 | negative selection | 11312319 | 59466806 | 59466829 | 18 | - | 28162770 | EOL1 | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | 1.0970149675753005 | [62] | [70] | 8 | hSpCas9 | negative selection | 11312320 | 59439789 | 59439812 | 18 | - | 28162770 | MOLM13 | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | 0.371213362132905 | [107] | [100] | 2 | hSpCas9 | negative selection | 11481680 | 59466762 | 59466785 | 18 | - | 28162770 | MOLM13 | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 0.6610726781244012 | [334] | [382] | 5 | hSpCas9 | negative selection | 11481681 | 59439763 | 59439786 | 18 | + | 28162770 | MOLM13 | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 1.355648116974901 | [166] | [308] | 9 | hSpCas9 | negative selection | 11481682 | 59466864 | 59466887 | 18 | - | 28162770 | MOLM13 | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | 2.1712380858550815 | [342] | [1116] | 9 | hSpCas9 | negative selection | 11481683 | 59439550 | 59439573 | 18 | - | 28162770 | MOLM13 | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | -0.11707311917657748 | [113] | [75] | 0 | hSpCas9 | negative selection | 11481684 | 59469498 | 59469521 | 18 | - | 28162770 | MOLM13 | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.13244648018273508 | [428] | [339] | 0 | hSpCas9 | negative selection | 11481685 | 59466806 | 59466829 | 18 | - | 28162770 | MOLM13 | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | -0.054063321650776874 | [55] | [38] | 0 | hSpCas9 | negative selection | 11481686 | 59439789 | 59439812 | 18 | - | 28162770 | HEL | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | -0.712741822598032 | [86] | [33] | -4 | hSpCas9 | negative selection | 11651046 | 59466762 | 59466785 | 18 | - | 28162770 | HEL | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 0.7599223713706961 | [259] | [281] | 6 | hSpCas9 | negative selection | 11651047 | 59439763 | 59439786 | 18 | + | 28162770 | HEL | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 0.979334976676555 | [136] | [172] | 8 | hSpCas9 | negative selection | 11651048 | 59466864 | 59466887 | 18 | - | 28162770 | HEL | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | 0.9420181879425192 | [320] | [394] | 7 | hSpCas9 | negative selection | 11651049 | 59439550 | 59439573 | 18 | - | 28162770 | HEL | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | -0.34594585477180895 | [126] | [63] | -2 | hSpCas9 | negative selection | 11651050 | 59469498 | 59469521 | 18 | - | 28162770 | HEL | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.5155036437042493 | [307] | [281] | 4 | hSpCas9 | negative selection | 11651051 | 59466806 | 59466829 | 18 | - | 28162770 | HEL | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | 0.42772594102950645 | [64] | [55] | 3 | hSpCas9 | negative selection | 11651052 | 59439789 | 59439812 | 18 | - | 28162770 | MV411 | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | 1.5567656088905042 | [68] | [170] | 9 | hSpCas9 | negative selection | 11820412 | 59466762 | 59466785 | 18 | - | 28162770 | MV411 | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 0.717277435300206 | [225] | [312] | 6 | hSpCas9 | negative selection | 11820413 | 59439763 | 59439786 | 18 | + | 28162770 | MV411 | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 1.1959072501426933 | [113] | [219] | 9 | hSpCas9 | negative selection | 11820414 | 59466864 | 59466887 | 18 | - | 28162770 | MV411 | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | 0.39944064422782527 | [224] | [249] | 3 | hSpCas9 | negative selection | 11820415 | 59439550 | 59439573 | 18 | - | 28162770 | MV411 | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | 0.6669764422965601 | [79] | [106] | 6 | hSpCas9 | negative selection | 11820416 | 59469498 | 59469521 | 18 | - | 28162770 | MV411 | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.34625528700069064 | [267] | [286] | 3 | hSpCas9 | negative selection | 11820417 | 59466806 | 59466829 | 18 | - | 28162770 | MV411 | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | -0.14487987199598473 | [41] | [31] | -1 | hSpCas9 | negative selection | 11820418 | 59439789 | 59439812 | 18 | - | 28162770 | MONOMAC1 | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | 0.4482982716410844 | [38] | [60] | 4 | hSpCas9 | negative selection | 11989778 | 59466762 | 59466785 | 18 | - | 28162770 | MONOMAC1 | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | -0.04196745056672019 | [140] | [156] | 0 | hSpCas9 | negative selection | 11989779 | 59439763 | 59439786 | 18 | + | 28162770 | MONOMAC1 | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 0.2673667295402697 | [78] | [108] | 2 | hSpCas9 | negative selection | 11989780 | 59466864 | 59466887 | 18 | - | 28162770 | MONOMAC1 | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | -0.7501152867609238 | [178] | [121] | -6 | hSpCas9 | negative selection | 11989781 | 59439550 | 59439573 | 18 | - | 28162770 | MONOMAC1 | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | -0.1970368470595537 | [71] | [71] | -2 | hSpCas9 | negative selection | 11989782 | 59469498 | 59469521 | 18 | - | 28162770 | MONOMAC1 | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.9088543215311844 | [150] | [324] | 8 | hSpCas9 | negative selection | 11989783 | 59466806 | 59466829 | 18 | - | 28162770 | MONOMAC1 | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | 2.329031964608034 | [24] | [143] | 9 | hSpCas9 | negative selection | 11989784 | 59439789 | 59439812 | 18 | - | 28162770 | OCIAML2 | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | 0.43626077036635735 | [21] | [164] | 4 | hSpCas9 | negative selection | 12159144 | 59466762 | 59466785 | 18 | - | 28162770 | OCIAML2 | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | -0.3511227307860722 | [54] | [238] | -3 | hSpCas9 | negative selection | 12159145 | 59439763 | 59439786 | 18 | + | 28162770 | OCIAML2 | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 0.861566605099028 | [13] | [140] | 8 | hSpCas9 | negative selection | 12159146 | 59466864 | 59466887 | 18 | - | 28162770 | OCIAML2 | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | 0.6438000636084478 | [52] | [458] | 6 | hSpCas9 | negative selection | 12159147 | 59439550 | 59439573 | 18 | - | 28162770 | OCIAML2 | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | 0.2819326239750636 | [22] | [154] | 2 | hSpCas9 | negative selection | 12159148 | 59469498 | 59469521 | 18 | - | 28162770 | OCIAML2 | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | 0.45183357428681836 | [42] | [325] | 4 | hSpCas9 | negative selection | 12159149 | 59466806 | 59466829 | 18 | - | 28162770 | OCIAML2 | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | -0.2576361019079627 | [10] | [50] | -2 | hSpCas9 | negative selection | 12159150 | 59439789 | 59439812 | 18 | - | 28162770 | OCIAML3 | viability | CCAGGACCAAAGGGAAGCCCAGG | CCBE1 | ENSG00000183287 | -0.41343539468234236 | [14] | [33] | -3 | hSpCas9 | negative selection | 12328510 | 59466762 | 59466785 | 18 | - | 28162770 | OCIAML3 | viability | GATGGGAAGACATGTACCAGGGG | CCBE1 | ENSG00000183287 | 0.21017303393829734 | [64] | [226] | 2 | hSpCas9 | negative selection | 12328511 | 59439763 | 59439786 | 18 | + | 28162770 | OCIAML3 | viability | CAGGAGGGCCTGGCATACCGGGG | CCBE1 | ENSG00000183287 | 0.45661843274580494 | [34] | [144] | 4 | hSpCas9 | negative selection | 12328512 | 59466864 | 59466887 | 18 | - | 28162770 | OCIAML3 | viability | GATGAGTGTGCCAGCAGCAATGG | CCBE1 | ENSG00000183287 | 0.7906562099111618 | [53] | [281] | 7 | hSpCas9 | negative selection | 12328513 | 59439550 | 59439573 | 18 | - | 28162770 | OCIAML3 | viability | CCAGGGGCACCAGGAAGAGATGG | CCBE1 | ENSG00000183287 | -1.1579085255174897 | [33] | [45] | -7 | hSpCas9 | negative selection | 12328514 | 59469498 | 59469521 | 18 | - | 28162770 | OCIAML3 | viability | GATATGACCGGGAGAGACACCGG | CCBE1 | ENSG00000183287 | -0.6600968307819355 | [66] | [127] | -5 | hSpCas9 | negative selection | 12328515 | 59466806 | 59466829 | 18 | - | 28162770 | OCIAML3 | viability | GCAGCTACCGCTGCGAGTGCCGG | CCBE1 | ENSG00000183287 | 1.455235878695686 | [17] | [148] | 9 | hSpCas9 | negative selection | 12328516 |