Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:5127
• Symbol:CDK16
• Description:cyclin dependent kinase 16

DataSource: http://genomecrispr.dkfz.de/#!/results/CDK16

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
47228589	47228612	X	+	26472758	Jiyoye	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	0.6245929874270293	[165]	[192]	4	hSpCas9	negative selection	28707
47224719	47224742	X	-	26472758	Jiyoye	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	0.6966819987008583	[17]	[21]	5	hSpCas9	negative selection	28708
47223648	47223671	X	+	26472758	Jiyoye	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	1.2739088506424092	[50]	[92]	7	hSpCas9	negative selection	28709
47224998	47225021	X	-	26472758	Jiyoye	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	1.2232125466632784	[70]	[124]	7	hSpCas9	negative selection	28710
47225053	47225076	X	+	26472758	Jiyoye	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	0.3160274934476781	[244]	[229]	2	hSpCas9	negative selection	28711
47226317	47226340	X	-	26472758	Jiyoye	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	0.5988346753027137	[182]	[208]	4	hSpCas9	negative selection	28712
47226868	47226891	X	-	26472758	Jiyoye	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	0.038175452855644165	[256]	[198]	0	hSpCas9	negative selection	28713
47227173	47227196	X	+	26472758	Jiyoye	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	0.2627854721706986	[41]	[37]	2	hSpCas9	negative selection	28714
47223588	47223611	X	+	26472758	Jiyoye	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	0.8526998023160961	[198]	[270]	6	hSpCas9	negative selection	28715
47224695	47224718	X	-	26472758	Jiyoye	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.4584007048610468	[248]	[257]	3	hSpCas9	negative selection	28716
47228589	47228612	X	+	26472758	KBM7	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	0.41185526232450737	[557,380]	[261,313]	4	hSpCas9	negative selection	219825
47224719	47224742	X	-	26472758	KBM7	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	-0.3895174243080779	[162,186]	[52,72]	-4	hSpCas9	negative selection	219826
47223648	47223671	X	+	26472758	KBM7	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	0.3961141420469208	[384,263]	[236,162]	4	hSpCas9	negative selection	219827
47224998	47225021	X	-	26472758	KBM7	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	0.7287081949348533	[545,519]	[561,285]	7	hSpCas9	negative selection	219828
47225053	47225076	X	+	26472758	KBM7	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	0.22887391720787265	[988,912]	[572,480]	2	hSpCas9	negative selection	219829
47226317	47226340	X	-	26472758	KBM7	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	0.7173984401050777	[744,369]	[450,388]	7	hSpCas9	negative selection	219830
47226868	47226891	X	-	26472758	KBM7	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	0.9141368839204912	[958,736]	[556,912]	8	hSpCas9	negative selection	219831
47227173	47227196	X	+	26472758	KBM7	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	-0.944635598949317	[364,335]	[53,113]	-6	hSpCas9	negative selection	219832
47223588	47223611	X	+	26472758	KBM7	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	0.2520011627468228	[880,906]	[734,296]	2	hSpCas9	negative selection	219833
47224695	47224718	X	-	26472758	KBM7	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.4337806787769545	[1017,1145]	[624,756]	5	hSpCas9	negative selection	219834
47228589	47228612	X	+	26472758	Raji	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	0.0355928523055892	[205]	[48]	0	hSpCas9	negative selection	410943
47224719	47224742	X	-	26472758	Raji	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	-0.6999713866840046	[132]	[18]	-5	hSpCas9	negative selection	410944
47223648	47223671	X	+	26472758	Raji	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	0.029381023372326398	[113]	[26]	0	hSpCas9	negative selection	410945
47224998	47225021	X	-	26472758	Raji	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	0.37997676963223814	[350]	[105]	3	hSpCas9	negative selection	410946
47225053	47225076	X	+	26472758	Raji	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	-0.19824274718466228	[439]	[88]	-2	hSpCas9	negative selection	410947
47226317	47226340	X	-	26472758	Raji	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	0.5308826134006394	[339]	[113]	5	hSpCas9	negative selection	410948
47226868	47226891	X	-	26472758	Raji	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	0.449273361918633	[444]	[140]	4	hSpCas9	negative selection	410949
47227173	47227196	X	+	26472758	Raji	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	-0.1711519640003823	[261]	[53]	-1	hSpCas9	negative selection	410950
47223588	47223611	X	+	26472758	Raji	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	-0.4052029099800766	[621]	[108]	-3	hSpCas9	negative selection	410951
47224695	47224718	X	-	26472758	Raji	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.5567725394432201	[497]	[169]	5	hSpCas9	negative selection	410952
47228589	47228612	X	+	26472758	K562	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	0.7086997459651401	[323]	[446]	6	hSpCas9	negative selection	602061
47224719	47224742	X	-	26472758	K562	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	1.4180668151514766	[85]	[193]	9	hSpCas9	negative selection	602062
47223648	47223671	X	+	26472758	K562	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	-0.9197699042267211	[250]	[111]	-5	hSpCas9	negative selection	602063
47224998	47225021	X	-	26472758	K562	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	1.5521710537894415	[449]	[1113]	9	hSpCas9	negative selection	602064
47225053	47225076	X	+	26472758	K562	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	0.49244654319516246	[756]	[898]	4	hSpCas9	negative selection	602065
47226317	47226340	X	-	26472758	K562	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	0.19368792554551711	[491]	[474]	1	hSpCas9	negative selection	602066
47226868	47226891	X	-	26472758	K562	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	0.3814291066360242	[531]	[584]	3	hSpCas9	negative selection	602067
47227173	47227196	X	+	26472758	K562	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	0.2791841458271233	[245]	[251]	2	hSpCas9	negative selection	602068
47223588	47223611	X	+	26472758	K562	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	0.9222906889022642	[901]	[1442]	7	hSpCas9	negative selection	602069
47224695	47224718	X	-	26472758	K562	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.6627202442671842	[882]	[1179]	5	hSpCas9	negative selection	602070
47223138	47223161	X	+	26627737	DLD1	viability	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	0.19139699346307282	[271]	[106,52,124]	2	hSpCas9	negative selection	845719
47223674	47223697	X	+	26627737	DLD1	viability	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.38958598729249205	[1310]	[449,850,351]	4	hSpCas9	negative selection	845720
47224377	47224400	X	+	26627737	DLD1	viability	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	0.17644575862486633	[670]	[203,325,191]	1	hSpCas9	negative selection	845721
47224642	47224665	X	-	26627737	DLD1	viability	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	-0.2142541407923681	[397]	[90,103,123]	-2	hSpCas9	negative selection	845722
47224854	47224877	X	+	26627737	DLD1	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.06663588508803364	[286]	[81,105,71]	0	hSpCas9	negative selection	845723
47225041	47225064	X	+	26627737	DLD1	viability	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	1.3890124575003464	[192]	[103,193,174]	9	hSpCas9	negative selection	845724
47223138	47223161	X	+	26627737	GBM cells	viability after 5 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	0.030703747441226836	[114]	[43,81]	0	hSpCas9	negative selection	928034
47223674	47223697	X	+	26627737	GBM cells	viability after 5 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.6183824018294917	[729]	[594,606]	8	hSpCas9	negative selection	928035
47224377	47224400	X	+	26627737	GBM cells	viability after 5 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	-0.25618370887898767	[362]	[168,156]	-4	hSpCas9	negative selection	928036
47224642	47224665	X	-	26627737	GBM cells	viability after 5 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.22883476052657847	[143]	[96,83]	3	hSpCas9	negative selection	928037
47224854	47224877	X	+	26627737	GBM cells	viability after 5 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.03641739863562041	[249]	[156,117]	0	hSpCas9	negative selection	928038
47225041	47225064	X	+	26627737	GBM cells	viability after 5 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	0.35834549352298284	[127]	[85,89]	5	hSpCas9	negative selection	928039
47223138	47223161	X	+	26627737	GBM cells	viability after 13 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	0.010015007947234755	[114]	[69,56]	0	hSpCas9	negative selection	1010349
47223674	47223697	X	+	26627737	GBM cells	viability after 13 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.5824176411555462	[729]	[677,523]	7	hSpCas9	negative selection	1010350
47224377	47224400	X	+	26627737	GBM cells	viability after 13 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	0.3959455292841084	[362]	[219,290]	5	hSpCas9	negative selection	1010351
47224642	47224665	X	-	26627737	GBM cells	viability after 13 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.6593423200831435	[143]	[161,91]	7	hSpCas9	negative selection	1010352
47224854	47224877	X	+	26627737	GBM cells	viability after 13 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.3194562106856138	[249]	[219,127]	4	hSpCas9	negative selection	1010353
47225041	47225064	X	+	26627737	GBM cells	viability after 13 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	0.7084646727361708	[127]	[118,108]	8	hSpCas9	negative selection	1010354
47223138	47223161	X	+	26627737	GBM cells	viability after 21 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	0.7465440378712055	[114]	[108,100]	7	hSpCas9	negative selection	1092664
47223674	47223697	X	+	26627737	GBM cells	viability after 21 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.4143616262161187	[729]	[550,507]	4	hSpCas9	negative selection	1092665
47224377	47224400	X	+	26627737	GBM cells	viability after 21 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	-0.3000622388962284	[362]	[155,163]	-3	hSpCas9	negative selection	1092666
47224642	47224665	X	-	26627737	GBM cells	viability after 21 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.31862473297357813	[143]	[95,98]	3	hSpCas9	negative selection	1092667
47224854	47224877	X	+	26627737	GBM cells	viability after 21 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.33125730674023823	[249]	[108,106]	-3	hSpCas9	negative selection	1092668
47225041	47225064	X	+	26627737	GBM cells	viability after 21 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	0.35506589068960315	[127]	[101,76]	3	hSpCas9	negative selection	1092669
47223138	47223161	X	+	26627737	RPE1	viability after 9 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	-0.6716732356692429	[523]	[64,151]	-5	hSpCas9	negative selection	1174979
47223674	47223697	X	+	26627737	RPE1	viability after 9 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.9671416028986866	[1723]	[1038,1075]	6	hSpCas9	negative selection	1174980
47224377	47224400	X	+	26627737	RPE1	viability after 9 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	0.07093832787651644	[1188]	[359,430]	0	hSpCas9	negative selection	1174981
47224642	47224665	X	-	26627737	RPE1	viability after 9 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.6727240101423712	[253]	[100,159]	4	hSpCas9	negative selection	1174982
47224854	47224877	X	+	26627737	RPE1	viability after 9 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.9260577363621163	[425]	[145,391]	6	hSpCas9	negative selection	1174983
47225041	47225064	X	+	26627737	RPE1	viability after 9 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	-0.42977028301478004	[320]	[64,86]	-3	hSpCas9	negative selection	1174984
47223138	47223161	X	+	26627737	RPE1	viability after 12 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	-0.6061529566001059	[523]	[23,164]	-4	hSpCas9	negative selection	1257294
47223674	47223697	X	+	26627737	RPE1	viability after 12 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.6252133202340087	[1723]	[745,680]	4	hSpCas9	negative selection	1257295
47224377	47224400	X	+	26627737	RPE1	viability after 12 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	-0.10122164437778036	[1188]	[392,196]	0	hSpCas9	negative selection	1257296
47224642	47224665	X	-	26627737	RPE1	viability after 12 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	1.2732492179637904	[253]	[128,202]	7	hSpCas9	negative selection	1257297
47224854	47224877	X	+	26627737	RPE1	viability after 12 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.8285640335641835	[425]	[92,319]	5	hSpCas9	negative selection	1257298
47225041	47225064	X	+	26627737	RPE1	viability after 12 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	-0.4847906312336778	[320]	[65,56]	-3	hSpCas9	negative selection	1257299
47223138	47223161	X	+	26627737	RPE1	viability after 15 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	-0.2151718813693455	[523]	[116,137]	-1	hSpCas9	negative selection	1339609
47223674	47223697	X	+	26627737	RPE1	viability after 15 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.5155052923047063	[1723]	[604,785]	3	hSpCas9	negative selection	1339610
47224377	47224400	X	+	26627737	RPE1	viability after 15 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	-0.12494314253112027	[1188]	[339,277]	-1	hSpCas9	negative selection	1339611
47224642	47224665	X	-	26627737	RPE1	viability after 15 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	-0.31617620643204813	[253]	[73,41]	-2	hSpCas9	negative selection	1339612
47224854	47224877	X	+	26627737	RPE1	viability after 15 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.9176225713738615	[425]	[219,234]	5	hSpCas9	negative selection	1339613
47225041	47225064	X	+	26627737	RPE1	viability after 15 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	0.5419372568040224	[320]	[176,88]	3	hSpCas9	negative selection	1339614
47223138	47223161	X	+	26627737	RPE1	viability after 18 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	-0.7317117177432918	[523]	[45,126]	-4	hSpCas9	negative selection	1421924
47223674	47223697	X	+	26627737	RPE1	viability after 18 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.5622606318035033	[1723]	[569,811]	3	hSpCas9	negative selection	1421925
47224377	47224400	X	+	26627737	RPE1	viability after 18 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	-0.549205630159459	[1188]	[212,225]	-3	hSpCas9	negative selection	1421926
47224642	47224665	X	-	26627737	RPE1	viability after 18 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.5188992528714722	[253]	[89,106]	3	hSpCas9	negative selection	1421927
47224854	47224877	X	+	26627737	RPE1	viability after 18 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.807506303233196	[425]	[148,256]	5	hSpCas9	negative selection	1421928
47225041	47225064	X	+	26627737	RPE1	viability after 18 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	-0.7386902507002087	[320]	[63,38]	-4	hSpCas9	negative selection	1421929
47223138	47223161	X	+	26627737	HeLa	viability after 8 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	0.3750233141190499	[186]	[87,152,73]	3	hSpCas9	negative selection	1504239
47223674	47223697	X	+	26627737	HeLa	viability after 8 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.4449749463500474	[1476]	[892,939,800]	4	hSpCas9	negative selection	1504240
47224377	47224400	X	+	26627737	HeLa	viability after 8 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	1.7403793459530743	[326]	[777,374,348]	9	hSpCas9	negative selection	1504241
47224642	47224665	X	-	26627737	HeLa	viability after 8 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.969759804315059	[203]	[242,226,73]	7	hSpCas9	negative selection	1504242
47224854	47224877	X	+	26627737	HeLa	viability after 8 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.1798206237506108	[303]	[170,26,248]	1	hSpCas9	negative selection	1504243
47225041	47225064	X	+	26627737	HeLa	viability after 8 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	0.36000178906303826	[308]	[110,173,215]	3	hSpCas9	negative selection	1504244
47223138	47223161	X	+	26627737	HeLa	viability after 12 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	-0.04939545779553578	[186]	[84,58,81]	0	hSpCas9	negative selection	1586554
47223674	47223697	X	+	26627737	HeLa	viability after 12 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.4069337108477393	[1476]	[741,921,749]	3	hSpCas9	negative selection	1586555
47224377	47224400	X	+	26627737	HeLa	viability after 12 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	1.3286446286332523	[326]	[562,138,343]	8	hSpCas9	negative selection	1586556
47224642	47224665	X	-	26627737	HeLa	viability after 12 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.762607587877437	[203]	[178,115,137]	6	hSpCas9	negative selection	1586557
47224854	47224877	X	+	26627737	HeLa	viability after 12 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.6055918342188185	[303]	[270,94,219]	5	hSpCas9	negative selection	1586558
47225041	47225064	X	+	26627737	HeLa	viability after 12 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	-0.30972144855285827	[308]	[131,73,106]	-3	hSpCas9	negative selection	1586559
47223138	47223161	X	+	26627737	HeLa	viability after 15 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	-0.520869195579468	[186]	[46,25,88]	-4	hSpCas9	negative selection	1668869
47223674	47223697	X	+	26627737	HeLa	viability after 15 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.5421381498994573	[1476]	[717,934,983]	4	hSpCas9	negative selection	1668870
47224377	47224400	X	+	26627737	HeLa	viability after 15 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	1.0869220692486734	[326]	[262,309,274]	7	hSpCas9	negative selection	1668871
47224642	47224665	X	-	26627737	HeLa	viability after 15 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	1.0236367072031909	[203]	[251,77,175]	7	hSpCas9	negative selection	1668872
47224854	47224877	X	+	26627737	HeLa	viability after 15 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.4612093026427214	[303]	[108,279,118]	4	hSpCas9	negative selection	1668873
47225041	47225064	X	+	26627737	HeLa	viability after 15 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	0.4479861493673453	[308]	[150,144,222]	4	hSpCas9	negative selection	1668874
47223138	47223161	X	+	26627737	HeLa	viability after 18 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	-0.5008569052766882	[186]	[30,23,88]	-4	hSpCas9	negative selection	1751184
47223674	47223697	X	+	26627737	HeLa	viability after 18 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.5261944019391609	[1476]	[467,767,983]	4	hSpCas9	negative selection	1751185
47224377	47224400	X	+	26627737	HeLa	viability after 18 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	1.1128767153338515	[326]	[182,260,274]	7	hSpCas9	negative selection	1751186
47224642	47224665	X	-	26627737	HeLa	viability after 18 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	1.0008227027301853	[203]	[169,56,175]	7	hSpCas9	negative selection	1751187
47224854	47224877	X	+	26627737	HeLa	viability after 18 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.43212990944835644	[303]	[71,224,118]	3	hSpCas9	negative selection	1751188
47225041	47225064	X	+	26627737	HeLa	viability after 18 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	0.4806052484690997	[308]	[104,124,222]	4	hSpCas9	negative selection	1751189
47223138	47223161	X	+	26627737	HCT116	viability after 6 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	1.2045929141591316	[295]	[230,38]	6	hSpCas9	negative selection	1833499
47223674	47223697	X	+	26627737	HCT116	viability after 6 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	-0.3451876944044667	[2691]	[657,153]	-2	hSpCas9	negative selection	1833500
47224377	47224400	X	+	26627737	HCT116	viability after 6 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	0.37003338550452114	[917]	[45,263]	2	hSpCas9	negative selection	1833501
47224642	47224665	X	-	26627737	HCT116	viability after 6 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.006090803383047405	[523]	[132,54]	0	hSpCas9	negative selection	1833502
47224854	47224877	X	+	26627737	HCT116	viability after 6 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.9615170900147967	[770]	[78,52]	-5	hSpCas9	negative selection	1833503
47225041	47225064	X	+	26627737	HCT116	viability after 6 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	-2.2240199069022983	[479]	[39,2]	-8	hSpCas9	negative selection	1833504
47223138	47223161	X	+	26627737	HCT116	viability after 8 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	-1.4515896287834424	[383]	[65,97,67]	-9	hSpCas9	negative selection	1915814
47223674	47223697	X	+	26627737	HCT116	viability after 8 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.2955434218275661	[1050]	[524,805,796]	3	hSpCas9	negative selection	1915815
47224377	47224400	X	+	26627737	HCT116	viability after 8 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	-0.22036536164568332	[538]	[185,275,300]	-3	hSpCas9	negative selection	1915816
47224642	47224665	X	-	26627737	HCT116	viability after 8 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.49804134128119903	[89]	[36,58,112]	5	hSpCas9	negative selection	1915817
47224854	47224877	X	+	26627737	HCT116	viability after 8 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	1.069020895674974	[147]	[194,170,147]	8	hSpCas9	negative selection	1915818
47225041	47225064	X	+	26627737	HCT116	viability after 8 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	-0.6016610926765757	[257]	[134,69,76]	-6	hSpCas9	negative selection	1915819
47223138	47223161	X	+	26627737	HCT116	viability after 9 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	-1.845031935638184	[295]	[21,21]	-8	hSpCas9	negative selection	1998129
47223674	47223697	X	+	26627737	HCT116	viability after 9 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	-0.4326521198606019	[2691]	[488,566]	-3	hSpCas9	negative selection	1998130
47224377	47224400	X	+	26627737	HCT116	viability after 9 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	-0.8570831576055343	[917]	[198,84]	-6	hSpCas9	negative selection	1998131
47224642	47224665	X	-	26627737	HCT116	viability after 9 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.43064240837723144	[523]	[182,192]	3	hSpCas9	negative selection	1998132
47224854	47224877	X	+	26627737	HCT116	viability after 9 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-1.0567658556010329	[770]	[146,60]	-6	hSpCas9	negative selection	1998133
47225041	47225064	X	+	26627737	HCT116	viability after 9 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	-0.7381557662064724	[479]	[44,101]	-5	hSpCas9	negative selection	1998134
47223138	47223161	X	+	26627737	HCT116	viability after 12 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	-1.2312748275832444	[383]	[64,97,96]	-8	hSpCas9	negative selection	2080444
47223674	47223697	X	+	26627737	HCT116	viability after 12 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.5808547386789296	[1050]	[667,854,969]	5	hSpCas9	negative selection	2080445
47224377	47224400	X	+	26627737	HCT116	viability after 12 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	0.14377753111112723	[538]	[320,307,308]	1	hSpCas9	negative selection	2080446
47224642	47224665	X	-	26627737	HCT116	viability after 12 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.8722163086201642	[89]	[94,86,76]	7	hSpCas9	negative selection	2080447
47224854	47224877	X	+	26627737	HCT116	viability after 12 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.6242646804151795	[147]	[151,84,118]	6	hSpCas9	negative selection	2080448
47225041	47225064	X	+	26627737	HCT116	viability after 12 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	-0.6872083919531146	[257]	[126,89,31]	-6	hSpCas9	negative selection	2080449
47223138	47223161	X	+	26627737	HCT116	viability after 15 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	-1.1940674974604437	[383]	[123,111,56]	-8	hSpCas9	negative selection	2162759
47223674	47223697	X	+	26627737	HCT116	viability after 15 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.5525064379387632	[1050]	[869,910,872]	5	hSpCas9	negative selection	2162760
47224377	47224400	X	+	26627737	HCT116	viability after 15 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	0.05251083173439364	[538]	[109,474,351]	0	hSpCas9	negative selection	2162761
47224642	47224665	X	-	26627737	HCT116	viability after 15 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.620711895612206	[89]	[105,84,50]	5	hSpCas9	negative selection	2162762
47224854	47224877	X	+	26627737	HCT116	viability after 15 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.4181843135876465	[147]	[125,82,132]	4	hSpCas9	negative selection	2162763
47225041	47225064	X	+	26627737	HCT116	viability after 15 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	-0.7901925599932379	[257]	[147,61,54]	-7	hSpCas9	negative selection	2162764
47223138	47223161	X	+	26627737	HCT116	viability after 18 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	-0.7321489408469128	[383]	[118,153,56]	-6	hSpCas9	negative selection	2245074
47223674	47223697	X	+	26627737	HCT116	viability after 18 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.5551247828727681	[1050]	[678,959,578]	4	hSpCas9	negative selection	2245075
47224377	47224400	X	+	26627737	HCT116	viability after 18 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	0.41098395917086905	[538]	[270,534,214]	3	hSpCas9	negative selection	2245076
47224642	47224665	X	-	26627737	HCT116	viability after 18 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	1.0133043739928436	[89]	[26,56,185]	7	hSpCas9	negative selection	2245077
47224854	47224877	X	+	26627737	HCT116	viability after 18 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.3480782973163218	[147]	[96,81,94]	3	hSpCas9	negative selection	2245078
47225041	47225064	X	+	26627737	HCT116	viability after 18 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	-0.01749314093599899	[257]	[132,47,196]	0	hSpCas9	negative selection	2245079
47223544	47223567	X	+	24336569	HL60	viability	TTGCTCAGATCGCCATGGATCGG	CDK16	ENSG00000102225	1.1615562820942806	[247]	[1173]	8	hSpCas9	negative selection	2256625
47223556	47223579	X	-	24336569	HL60	viability	GATCTTCTTCATCCGATCCATGG	CDK16	ENSG00000102225	-0.6522295271200366	[631]	[850]	-5	hSpCas9	negative selection	2256626
47223562	47223585	X	+	24336569	HL60	viability	ATCGGATGAAGAAGATCAAACGG	CDK16	ENSG00000102225	0.2774348884086302	[939]	[2410]	2	hSpCas9	negative selection	2256627
47223585	47223608	X	+	24336569	HL60	viability	CAGCTGTCAATGACACTCCGAGG	CDK16	ENSG00000102225	1.8077167324192378	[305]	[2266]	9	hSpCas9	negative selection	2256628
47223594	47223617	X	+	24336569	HL60	viability	ATGACACTCCGAGGTGGCCGAGG	CDK16	ENSG00000102225	0.48161528219381	[619]	[1831]	4	hSpCas9	negative selection	2256629
47223602	47223625	X	-	24336569	HL60	viability	TGTCTATGCCTCGGCCACCTCGG	CDK16	ENSG00000102225	1.0228725591858392	[199]	[859]	7	hSpCas9	negative selection	2256630
47223611	47223634	X	-	24336569	HL60	viability	CATTGGTCTTGTCTATGCCTCGG	CDK16	ENSG00000102225	0.7547456841008928	[593]	[2120]	6	hSpCas9	negative selection	2256631
47223638	47223661	X	-	24336569	HL60	viability	CATCCAGGCCTATCTGCTCAGGG	CDK16	ENSG00000102225	0.7414205197223122	[659]	[2334]	6	hSpCas9	negative selection	2256632
47223645	47223668	X	+	24336569	HL60	viability	CAGATAGGCCTGGATGAGAGTGG	CDK16	ENSG00000102225	0.34639743900753106	[167]	[451]	3	hSpCas9	negative selection	2256633
47223651	47223674	X	+	24336569	HL60	viability	GGCCTGGATGAGAGTGGTGGTGG	CDK16	ENSG00000102225	-0.18856184329948067	[1215]	[2257]	-2	hSpCas9	negative selection	2256634
47223544	47223567	X	+	24336569	KBM7	viability	TTGCTCAGATCGCCATGGATCGG	CDK16	ENSG00000102225	-0.14238029639331676	[398]	[985]	-1	hSpCas9	negative selection	2323802
47223556	47223579	X	-	24336569	KBM7	viability	GATCTTCTTCATCCGATCCATGG	CDK16	ENSG00000102225	-0.0516505202177433	[322]	[849]	0	hSpCas9	negative selection	2323803
47223562	47223585	X	+	24336569	KBM7	viability	ATCGGATGAAGAAGATCAAACGG	CDK16	ENSG00000102225	-0.06959612982822705	[1049]	[2728]	0	hSpCas9	negative selection	2323804
47223585	47223608	X	+	24336569	KBM7	viability	CAGCTGTCAATGACACTCCGAGG	CDK16	ENSG00000102225	-0.3301425940105853	[565]	[1227]	-3	hSpCas9	negative selection	2323805
47223594	47223617	X	+	24336569	KBM7	viability	ATGACACTCCGAGGTGGCCGAGG	CDK16	ENSG00000102225	0.5759041503096267	[715]	[2910]	5	hSpCas9	negative selection	2323806
47223602	47223625	X	-	24336569	KBM7	viability	TGTCTATGCCTCGGCCACCTCGG	CDK16	ENSG00000102225	0.19314657569428273	[202]	[632]	1	hSpCas9	negative selection	2323807
47223611	47223634	X	-	24336569	KBM7	viability	CATTGGTCTTGTCTATGCCTCGG	CDK16	ENSG00000102225	0.49953369045121804	[381]	[1472]	4	hSpCas9	negative selection	2323808
47223638	47223661	X	-	24336569	KBM7	viability	CATCCAGGCCTATCTGCTCAGGG	CDK16	ENSG00000102225	0.24993119055353802	[492]	[1598]	2	hSpCas9	negative selection	2323809
47223645	47223668	X	+	24336569	KBM7	viability	CAGATAGGCCTGGATGAGAGTGG	CDK16	ENSG00000102225	0.34233527756628257	[213]	[739]	3	hSpCas9	negative selection	2323810
47223651	47223674	X	+	24336569	KBM7	viability	GGCCTGGATGAGAGTGGTGGTGG	CDK16	ENSG00000102225	-0.535140370964982	[916]	[1725]	-4	hSpCas9	negative selection	2323811
47222861	47222884	X	-	25494202	A375	resistance to PLX-4720 (puromycin)	AGTGTACACCAGCTCTTCTCAGG	CDK16	ENSG00000102225	-0.34056279161502623	[717,198]	[124,28]	-1	dCas9-VP64	positive selection	2405845
47222838	47222861	X	-	25494202	A375	resistance to PLX-4720 (puromycin)	GCTGCCAGAACGGTTTGATCAGG	CDK16	ENSG00000102225	-1.3096306898898402	[132,299]	[9,27]	-7	dCas9-VP64	positive selection	2405846
47222893	47222916	X	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGGTGGGATTGTGTGGAGGGCGG	CDK16	ENSG00000102225	-0.38440471399976195	[6,67]	[2,8]	-2	dCas9-VP64	positive selection	2405847
47218502	47218525	X	-	25494202	A375	resistance to PLX-4720 (puromycin)	GCAGAAGTTTGCTAGCGCCTAGG	CDK16	ENSG00000102225	2.655492724614936	[141,61]	[260,10]	8	dCas9-VP64	positive selection	2439634
47218480	47218503	X	-	25494202	A375	resistance to PLX-4720 (puromycin)	GTGAGCAGTGGCCAGTAACCTGG	CDK16	ENSG00000102225	1.5637034617929442	[55,54]	[21,50]	6	dCas9-VP64	positive selection	2439635
47218524	47218547	X	-	25494202	A375	resistance to PLX-4720 (puromycin)	TTAGTACTCAGTTCCGATCTTGG	CDK16	ENSG00000102225	-0.7801391051053492	[121,257]	[21,25]	-4	dCas9-VP64	positive selection	2439636
47217965	47217988	X	+	25494202	A375	resistance to PLX-4720 (puromycin)	AATTATGACCAATCACCTTGCGG	CDK16	ENSG00000102225	0.18360135294332025	[4,29]	[3,3]	0	dCas9-VP64	positive selection	2460401
47218007	47218030	X	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGGAGGAGCTCAGAACAAAAAGG	CDK16	ENSG00000102225	-1.3959019847763456	[39,65]	[1,5]	-7	dCas9-VP64	positive selection	2460402
47217987	47218010	X	+	25494202	A375	resistance to PLX-4720 (puromycin)	GAATATTCGGCCTATAGCGAAGG	CDK16	ENSG00000102225	1.1007150013715035	[92,39]	[48,10]	4	dCas9-VP64	positive selection	2460403
47222861	47222884	X	-	25494202	A375	resistance to PLX-4720 (zeocin)	AGTGTACACCAGCTCTTCTCAGG	CDK16	ENSG00000102225	-1.2448200061244545	[271,74]	[36,10]	-9	dCas9-VP64	positive selection	2501100
47222838	47222861	X	-	25494202	A375	resistance to PLX-4720 (zeocin)	GCTGCCAGAACGGTTTGATCAGG	CDK16	ENSG00000102225	3.554440890192074	[104,134]	[26,869]	9	dCas9-VP64	positive selection	2501101
47222893	47222916	X	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGGTGGGATTGTGTGGAGGGCGG	CDK16	ENSG00000102225	-0.3701563675177286	[241,3]	[59,4]	-4	dCas9-VP64	positive selection	2501102
47218502	47218525	X	-	25494202	A375	resistance to PLX-4720 (zeocin)	GCAGAAGTTTGCTAGCGCCTAGG	CDK16	ENSG00000102225	1.1375400760489622	[118,191]	[19,196]	7	dCas9-VP64	positive selection	2534889
47218480	47218503	X	-	25494202	A375	resistance to PLX-4720 (zeocin)	GTGAGCAGTGGCCAGTAACCTGG	CDK16	ENSG00000102225	2.122781310959525	[20,25]	[16,48]	8	dCas9-VP64	positive selection	2534890
47218524	47218547	X	-	25494202	A375	resistance to PLX-4720 (zeocin)	TTAGTACTCAGTTCCGATCTTGG	CDK16	ENSG00000102225	1.1440898989878765	[150,113]	[33,153]	7	dCas9-VP64	positive selection	2534891
47217965	47217988	X	+	25494202	A375	resistance to PLX-4720 (zeocin)	AATTATGACCAATCACCTTGCGG	CDK16	ENSG00000102225	0.9150305568760907	[107,18]	[34,42]	6	dCas9-VP64	positive selection	2555656
47218007	47218030	X	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGGAGGAGCTCAGAACAAAAAGG	CDK16	ENSG00000102225	-1.0015065974402155	[11,146]	[7,15]	-8	dCas9-VP64	positive selection	2555657
47217987	47218010	X	+	25494202	A375	resistance to PLX-4720 (zeocin)	GAATATTCGGCCTATAGCGAAGG	CDK16	ENSG00000102225	-1.5501498974081103	[12,162]	[4,12]	-9	dCas9-VP64	positive selection	2555658
47223539	47223562	X	+	27013184	SW480	treatment with recombinant TRAIL	GTCCCTTGCTCAGATCGCCATGG	CDK16	ENSG00000102225	-2.0572541112259346	[213,375]	[21,40]	-7	hSpCas9	positive selection	2956585
47223544	47223567	X	+	27013184	SW480	treatment with recombinant TRAIL	TTGCTCAGATCGCCATGGATCGG	CDK16	ENSG00000102225	-0.5085320848798363	[496,468]	[169,113]	-2	hSpCas9	positive selection	2956586
47223562	47223585	X	+	27013184	SW480	treatment with recombinant TRAIL	ATCGGATGAAGAAGATCAAACGG	CDK16	ENSG00000102225	0.9551301106213135	[1,43]	[1,39]	4	hSpCas9	positive selection	2956587
47223585	47223608	X	+	27013184	SW480	treatment with recombinant TRAIL	CAGCTGTCAATGACACTCCGAGG	CDK16	ENSG00000102225	-0.759536346407159	[175,193]	[41,53]	-3	hSpCas9	positive selection	2956588
47223588	47223611	X	+	27013184	SW480	treatment with recombinant TRAIL	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	-1.5849635784969431	[197,319]	[59,2]	-6	hSpCas9	positive selection	2956589
47223594	47223617	X	+	27013184	SW480	treatment with recombinant TRAIL	ATGACACTCCGAGGTGGCCGAGG	CDK16	ENSG00000102225	1.6080822396708983	[406,525]	[465,806]	7	hSpCas9	positive selection	2956590
47227173	47227196	X	+	27013184	SW480	treatment with recombinant TRAIL	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	-1.5488599351823766	[152,145]	[5,44]	-6	hSpCas9	positive selection	2956591
47223630	47223653	X	+	27013184	SW480	treatment with recombinant TRAIL	AATGGTGCCCCTGAGCAGATAGG	CDK16	ENSG00000102225	1.5603876966344838	[255,354]	[336,448]	7	hSpCas9	positive selection	2956592
47227174	47227197	X	+	27013184	SW480	treatment with recombinant TRAIL	GTGGCAGACTTGATAGCGACGGG	CDK16	ENSG00000102225	2.52275728968427	[86,233]	[347,429]	9	hSpCas9	positive selection	2956593
47223635	47223658	X	+	27013184	SW480	treatment with recombinant TRAIL	TGCCCCTGAGCAGATAGGCCTGG	CDK16	ENSG00000102225	-2.28652951276584	[178,231]	[5,34]	-8	hSpCas9	positive selection	2956594
47227175	47227198	X	+	27013184	SW480	treatment with recombinant TRAIL	TGGCAGACTTGATAGCGACGGGG	CDK16	ENSG00000102225	-1.1634670392527635	[173,128]	[36,18]	-5	hSpCas9	positive selection	2956595
47223645	47223668	X	+	27013184	SW480	treatment with recombinant TRAIL	CAGATAGGCCTGGATGAGAGTGG	CDK16	ENSG00000102225	-4.151190187539141	[49,120]	[1,1]	-9	hSpCas9	positive selection	2956596
47223715	47223738	X	+	27013184	SW480	treatment with recombinant TRAIL	CTGGGGAACTTCGTTCTGCACGG	CDK16	ENSG00000102225	-0.5810089364645844	[430,216]	[56,151]	-3	hSpCas9	positive selection	2956597
47223716	47223739	X	+	27013184	SW480	treatment with recombinant TRAIL	TGGGGAACTTCGTTCTGCACGGG	CDK16	ENSG00000102225	-0.13449517091200047	[235,239]	[57,143]	0	hSpCas9	positive selection	2956598
47223717	47223740	X	+	27013184	SW480	treatment with recombinant TRAIL	GGGGAACTTCGTTCTGCACGGGG	CDK16	ENSG00000102225	-0.16056160059259938	[524,493]	[143,272]	0	hSpCas9	positive selection	2956599
47227217	47227240	X	+	27013184	SW480	treatment with recombinant TRAIL	GTTGCAGGTGAGACCACCTTGGG	CDK16	ENSG00000102225	2.012162189382791	[35,34]	[65,55]	8	hSpCas9	positive selection	2956600
47223750	47223773	X	+	27013184	SW480	treatment with recombinant TRAIL	TCTGCACCAGGTGGGTCCACTGG	CDK16	ENSG00000102225	-0.7241875446940098	[1122,1391]	[215,480]	-3	hSpCas9	positive selection	2956601
47223541	47223564	X	-	27013184	SW480	treatment with recombinant TRAIL	ATCCATGGCGATCTGAGCAAGGG	CDK16	ENSG00000102225	-5.708055482880294	[286,344]	[2,1]	-9	hSpCas9	positive selection	2956602
47223542	47223565	X	-	27013184	SW480	treatment with recombinant TRAIL	GATCCATGGCGATCTGAGCAAGG	CDK16	ENSG00000102225	-0.21012241630040518	[438,842]	[224,242]	-1	hSpCas9	positive selection	2956603
47223556	47223579	X	-	27013184	SW480	treatment with recombinant TRAIL	GATCTTCTTCATCCGATCCATGG	CDK16	ENSG00000102225	1.2080375718403693	[566,650]	[680,492]	5	hSpCas9	positive selection	2956604
47223628	47223651	X	-	27013184	SW480	treatment with recombinant TRAIL	TATCTGCTCAGGGGCACCATTGG	CDK16	ENSG00000102225	1.0931611468332527	[220,385]	[289,247]	5	hSpCas9	positive selection	2956605
47223637	47223660	X	-	27013184	SW480	treatment with recombinant TRAIL	ATCCAGGCCTATCTGCTCAGGGG	CDK16	ENSG00000102225	-0.23698721301997083	[307,364]	[99,153]	-1	hSpCas9	positive selection	2956606
47223638	47223661	X	-	27013184	SW480	treatment with recombinant TRAIL	CATCCAGGCCTATCTGCTCAGGG	CDK16	ENSG00000102225	-0.245802791271498	[123,197]	[37,84]	-1	hSpCas9	positive selection	2956607
47223639	47223662	X	-	27013184	SW480	treatment with recombinant TRAIL	TCATCCAGGCCTATCTGCTCAGG	CDK16	ENSG00000102225	0.41575439853509977	[314,318]	[169,199]	2	hSpCas9	positive selection	2956608
47223699	47223722	X	-	27013184	SW480	treatment with recombinant TRAIL	TCCCCAGGAGCAGCACGTGTGGG	CDK16	ENSG00000102225	-0.9949878210719583	[395,1892]	[102,418]	-4	hSpCas9	positive selection	2956609
47223700	47223723	X	-	27013184	SW480	treatment with recombinant TRAIL	TTCCCCAGGAGCAGCACGTGTGG	CDK16	ENSG00000102225	-1.5546385654293102	[244,270]	[26,52]	-6	hSpCas9	positive selection	2956610
47223714	47223737	X	-	27013184	SW480	treatment with recombinant TRAIL	CGTGCAGAACGAAGTTCCCCAGG	CDK16	ENSG00000102225	-1.5244499998658816	[85,63]	[17,1]	-6	hSpCas9	positive selection	2956611
47223740	47223763	X	-	27013184	SW480	treatment with recombinant TRAIL	CACCTGGTGCAGAGCTGAGTGGG	CDK16	ENSG00000102225	-0.2296399087880595	[392,337]	[82,209]	-1	hSpCas9	positive selection	2956612
47223756	47223779	X	-	27013184	SW480	treatment with recombinant TRAIL	GGATAGCCAGTGGACCCACCTGG	CDK16	ENSG00000102225	-0.5265272919600379	[239,243]	[31,129]	-2	hSpCas9	positive selection	2956613
47227170	47227193	X	-	27013184	SW480	treatment with recombinant TRAIL	TCGCTATCAAGTCTGCCACAAGG	CDK16	ENSG00000102225	-1.9688389888713174	[79,118]	[4,18]	-7	hSpCas9	positive selection	2956614
47223613	47223636	X	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CGAGGCATAGACAAGACCAATGG	CDK16	ENSG00000102225	-0.987325840323416	[2,2]	[1,0]	-9	hSpCas9	positive selection	2978164
47225813	47225836	X	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCTACATGACATTATCCACACGG	CDK16	ENSG00000102225	0.33154934645172196	[3,3]	[3,3]	7	hSpCas9	positive selection	2978165
47224646	47224669	X	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCTGACATCCGGCTGCCTGAGGG	CDK16	ENSG00000102225	-0.537326601553049	[3,3]	[3,0]	-7	hSpCas9	positive selection	2978166
47225847	47225870	X	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TACCAGGTACTCAAAGACAAGGG	CDK16	ENSG00000102225	0.012942480725675526	[4,4]	[4,3]	0	hSpCas9	positive selection	2978167
47223613	47223636	X	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CGAGGCATAGACAAGACCAATGG	CDK16	ENSG00000102225	-0.8082664737436775	[2,2]	[1,0]	-9	hSpCas9	positive selection	3046022
47225813	47225836	X	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCTACATGACATTATCCACACGG	CDK16	ENSG00000102225	-0.2066416044013974	[3,3]	[2,1]	-3	hSpCas9	positive selection	3046023
47224646	47224669	X	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCTGACATCCGGCTGCCTGAGGG	CDK16	ENSG00000102225	0.10918752682713592	[3,3]	[2,2]	2	hSpCas9	positive selection	3046024
47225847	47225870	X	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TACCAGGTACTCAAAGACAAGGG	CDK16	ENSG00000102225	-0.5910806245632216	[4,4]	[3,0]	-7	hSpCas9	positive selection	3046025
47224862	47224885		-	24336571	A375	resistance to PLX after 7 days	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.25500015434679435	[33,32]	[28,26]	-7	hSpCas9	positive selection	3104581
47224828	47224851		+	24336571	A375	resistance to PLX after 7 days	CCACAGTCTGAGATTGGCTTTGG	CDK16	ENSG00000102225	0.026549236346774308	[47,44]	[45,47]	1	hSpCas9	positive selection	3104582
47225076	47225099		+	24336571	A375	resistance to PLX after 7 days	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	-0.31931161726685575	[33,31]	[25,25]	-8	hSpCas9	positive selection	3104583
47225091	47225114		-	24336571	A375	resistance to PLX after 7 days	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.39545144187233183	[8,8]	[11,11]	8	hSpCas9	positive selection	3104584
47224862	47224885		-	24336571	A375	resistance to PLX after 14 days	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.6072431903564303	[26,34]	[8,8]	-7	hSpCas9	positive selection	3162374
47224828	47224851		+	24336571	A375	resistance to PLX after 14 days	CCACAGTCTGAGATTGGCTTTGG	CDK16	ENSG00000102225	-0.37211954798905067	[57,49]	[18,18]	-4	hSpCas9	positive selection	3162375
47225076	47225099		+	24336571	A375	resistance to PLX after 14 days	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	-1.4263574108224404	[34,31]	[5,4]	-9	hSpCas9	positive selection	3162376
47225091	47225114		-	24336571	A375	resistance to PLX after 14 days	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	-0.1030148354495383	[7,13]	[4,3]	-1	hSpCas9	positive selection	3162377
47224862	47224885		-	24336571	A375	viability after 7 days	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.14627759047649191	[38]	[33,32]	-2	hSpCas9	negative selection	3220167
47224828	47224851		+	24336571	A375	viability after 7 days	CCACAGTCTGAGATTGGCTTTGG	CDK16	ENSG00000102225	0.4403843308863091	[35]	[47,44]	6	hSpCas9	negative selection	3220168
47225076	47225099		+	24336571	A375	viability after 7 days	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.27334572523532974	[28]	[33,31]	4	hSpCas9	negative selection	3220169
47225091	47225114		-	24336571	A375	viability after 7 days	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.029995803132602528	[8]	[8,8]	0	hSpCas9	negative selection	3220170
47224862	47224885		-	24336571	A375	viability after 14 days	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.22378982347884602	[38]	[26,34]	-3	hSpCas9	negative selection	3277960
47224828	47224851		+	24336571	A375	viability after 14 days	CCACAGTCTGAGATTGGCTTTGG	CDK16	ENSG00000102225	0.6696883333858867	[35]	[57,49]	8	hSpCas9	negative selection	3277961
47225076	47225099		+	24336571	A375	viability after 14 days	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.3335296350418404	[28]	[34,31]	4	hSpCas9	negative selection	3277962
47225091	47225114		-	24336571	A375	viability after 14 days	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.32534842578321144	[8]	[7,13]	4	hSpCas9	negative selection	3277963
47225799	47225822	X	-	27383988	293T	resistance to West Nile virus (flavivirus)	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.31208267291780634	[180,198]	[0,0]	-2	hSpCas9	positive selection	3342387
47225076	47225099	X	+	27383988	293T	resistance to West Nile virus (flavivirus)	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	1.1472993028916592	[79,57]	[0,0]	5	hSpCas9	positive selection	3342388
47225091	47225114	X	-	27383988	293T	resistance to West Nile virus (flavivirus)	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	1.4614669282260604	[63,46]	[0,0]	6	hSpCas9	positive selection	3342389
47224854	47224877	X	+	27383988	293T	resistance to West Nile virus (flavivirus)	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.19123702098806272	[133,133]	[0,0]	1	hSpCas9	positive selection	3361619
47224862	47224885	X	-	27383988	293T	resistance to West Nile virus (flavivirus)	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.8719568054991315	[279,279]	[0,0]	-6	hSpCas9	positive selection	3361620
47225776	47225799	X	-	27383988	293T	resistance to West Nile virus (flavivirus)	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	1.8650087886670745	[41,41]	[0,0]	7	hSpCas9	positive selection	3361621
47223612	47223635	X	+	26780180	HT29	viability (Avana library 4 designs)	CGAGGCATAGACAAGACCAATGG	CDK16	ENSG00000102225	1.78183119268006	[]	[]	6	hSpCas9	negative selection	3414475
47225812	47225835	X	+	26780180	HT29	viability (Avana library 4 designs)	GCTACATGACATTATCCACACGG	CDK16	ENSG00000102225	1.39588097719106	[]	[]	5	hSpCas9	negative selection	3414476
47224645	47224668	X	+	26780180	HT29	viability (Avana library 4 designs)	GCTGACATCCGGCTGCCTGAGGG	CDK16	ENSG00000102225	0.396060089813037	[]	[]	1	hSpCas9	negative selection	3414477
47225847	47225870	X	-	26780180	HT29	viability (Avana library 4 designs)	TACCAGGTACTCAAAGACAAGGG	CDK16	ENSG00000102225	0.336906426679545	[]	[]	1	hSpCas9	negative selection	3414478
47224645	47224668	X	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCTGACATCCGGCTGCCTGAGGG	CDK16	ENSG00000102225	4.24190463178895	[]	[]	7	hSpCas9	negative selection	3491010
47223612	47223635	X	+	26780180	A375	viability (Avana lentiCRISPRv2)	CGAGGCATAGACAAGACCAATGG	CDK16	ENSG00000102225	1.87116590801268	[]	[]	2	hSpCas9	negative selection	3491011
47225812	47225835	X	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCTACATGACATTATCCACACGG	CDK16	ENSG00000102225	-6.30888579655151	[]	[]	-6	hSpCas9	negative selection	3491012
47225847	47225870	X	-	26780180	A375	viability (Avana lentiCRISPRv2)	TACCAGGTACTCAAAGACAAGGG	CDK16	ENSG00000102225	-5.96103046830838	[]	[]	-6	hSpCas9	negative selection	3491013
47224725	47224748	X	-	26780180	A375	viability (Avana lentiCRISPRv2)	TTACTAGGCTGACACGACGGAGG	CDK16	ENSG00000102225	1.9713627116322	[]	[]	3	hSpCas9	negative selection	3491014
47223594	47223617	X	+	26780180	A375	viability (Avana lentiCRISPRv2)	ATGACACTCCGAGGTGGCCGAGG	CDK16	ENSG00000102225	5.22119764349318	[]	[]	8	hSpCas9	negative selection	3491015
47224645	47224668	X	+	26780180	A375	viability (Avana lentiGuide)	GCTGACATCCGGCTGCCTGAGGG	CDK16	ENSG00000102225	-0.329181789234697	[]	[]	0	hSpCas9	negative selection	3599669
47223612	47223635	X	+	26780180	A375	viability (Avana lentiGuide)	CGAGGCATAGACAAGACCAATGG	CDK16	ENSG00000102225	-1.9542310231804	[]	[]	-3	hSpCas9	negative selection	3599670
47225812	47225835	X	+	26780180	A375	viability (Avana lentiGuide)	GCTACATGACATTATCCACACGG	CDK16	ENSG00000102225	2.09851733976008	[]	[]	2	hSpCas9	negative selection	3599671
47225847	47225870	X	-	26780180	A375	viability (Avana lentiGuide)	TACCAGGTACTCAAAGACAAGGG	CDK16	ENSG00000102225	2.13793556959688	[]	[]	2	hSpCas9	negative selection	3599672
47224725	47224748	X	-	26780180	A375	viability (Avana lentiGuide)	TTACTAGGCTGACACGACGGAGG	CDK16	ENSG00000102225	2.68640767798811	[]	[]	3	hSpCas9	negative selection	3599673
47223594	47223617	X	+	26780180	A375	viability (Avana lentiGuide)	ATGACACTCCGAGGTGGCCGAGG	CDK16	ENSG00000102225	-1.19371989787437	[]	[]	-2	hSpCas9	negative selection	3599674
47224645	47224668	X	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTGACATCCGGCTGCCTGAGGG	CDK16	ENSG00000102225	0.20603880001824992	[4]	[6,4]	6	hSpCas9	positive selection	3708328
47223612	47223635	X	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CGAGGCATAGACAAGACCAATGG	CDK16	ENSG00000102225	-0.05278522256861984	[4]	[6,1]	-1	hSpCas9	positive selection	3708329
47225812	47225835	X	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTACATGACATTATCCACACGG	CDK16	ENSG00000102225	-0.901646452606564	[4]	[2,1]	-8	hSpCas9	positive selection	3708330
47225847	47225870	X	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TACCAGGTACTCAAAGACAAGGG	CDK16	ENSG00000102225	-0.36493008071132166	[6]	[5,3]	-5	hSpCas9	positive selection	3708331
47224725	47224748	X	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTACTAGGCTGACACGACGGAGG	CDK16	ENSG00000102225	0.14439378287342403	[4]	[5,5]	4	hSpCas9	positive selection	3708332
47223594	47223617	X	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATGACACTCCGAGGTGGCCGAGG	CDK16	ENSG00000102225	0.3351260405118938	[5]	[6,6]	8	hSpCas9	positive selection	3708333
47224645	47224668	X	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTGACATCCGGCTGCCTGAGGG	CDK16	ENSG00000102225	-0.21713722740576102	[5]	[2,4]	-3	hSpCas9	positive selection	3816935
47223612	47223635	X	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CGAGGCATAGACAAGACCAATGG	CDK16	ENSG00000102225	-0.11749500751496761	[4]	[3,3]	-2	hSpCas9	positive selection	3816936
47225812	47225835	X	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTACATGACATTATCCACACGG	CDK16	ENSG00000102225	-0.6314821759928041	[5]	[1,3]	-7	hSpCas9	positive selection	3816937
47225847	47225870	X	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TACCAGGTACTCAAAGACAAGGG	CDK16	ENSG00000102225	0.24458176045500668	[6]	[6,5]	6	hSpCas9	positive selection	3816938
47224725	47224748	X	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTACTAGGCTGACACGACGGAGG	CDK16	ENSG00000102225	0.20635717083160748	[5]	[5,5]	5	hSpCas9	positive selection	3816939
47223594	47223617	X	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATGACACTCCGAGGTGGCCGAGG	CDK16	ENSG00000102225	0.2409501176382535	[5]	[6,4]	6	hSpCas9	positive selection	3816940
47224854	47224877	X	+	26780180	A375	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	1.65570140654501	[]	[]	8	hSpCas9	negative selection	3925106
47224862	47224885	X	-	26780180	A375	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.667104611224405	[]	[]	2	hSpCas9	negative selection	3925107
47225776	47225799	X	-	26780180	A375	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	0.97496151004767	[]	[]	4	hSpCas9	negative selection	3925108
47225076	47225099	X	+	26780180	A375	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.513380803370819	[]	[]	1	hSpCas9	negative selection	3925109
47225091	47225114	X	-	26780180	A375	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.760367903459029	[]	[]	3	hSpCas9	negative selection	3925110
47225799	47225822	X	-	26780180	A375	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	1.31626659248517	[]	[]	7	hSpCas9	negative selection	3925111
47224854	47224877	X	+	26780180	HT29	viability (GeCKOv2 library)	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	1.61266778514504	[]	[]	8	hSpCas9	negative selection	4033072
47224862	47224885	X	-	26780180	HT29	viability (GeCKOv2 library)	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.224452739966013	[]	[]	0	hSpCas9	negative selection	4033073
47225776	47225799	X	-	26780180	HT29	viability (GeCKOv2 library)	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	1.27387149221628	[]	[]	6	hSpCas9	negative selection	4033074
47225076	47225099	X	+	26780180	HT29	viability (GeCKOv2 library)	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.600530403530595	[]	[]	2	hSpCas9	negative selection	4033075
47225091	47225114	X	-	26780180	HT29	viability (GeCKOv2 library)	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.689046581183505	[]	[]	2	hSpCas9	negative selection	4033076
47225799	47225822	X	-	26780180	HT29	viability (GeCKOv2 library)	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	1.07389068617608	[]	[]	5	hSpCas9	negative selection	4033077
47224862	47224885	X	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.04641804478624734	[5]	[3,3]	1	hSpCas9	positive selection	4126610
47224828	47224851	X	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CCACAGTCTGAGATTGGCTTTGG	CDK16	ENSG00000102225	0.25222565026270893	[5]	[4,4]	6	hSpCas9	positive selection	4126611
47225076	47225099	X	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	-0.05332116202982423	[4]	[3,2]	-1	hSpCas9	positive selection	4126612
47225091	47225114	X	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	-0.16786172168681607	[3]	[1,1]	-4	hSpCas9	positive selection	4126613
47224862	47224885	X	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.9140348097731461	[4]	[4,2,3,4]	6	hSpCas9	positive selection	4190632
47224828	47224851	X	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CCACAGTCTGAGATTGGCTTTGG	CDK16	ENSG00000102225	0.3786751949596923	[4]	[5,3,3,0]	3	hSpCas9	positive selection	4190633
47225076	47225099	X	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.9743285052176578	[4]	[4,3,3,4]	6	hSpCas9	positive selection	4190634
47225091	47225114	X	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.2047588606368256	[2]	[0,0,2,0]	1	hSpCas9	positive selection	4190635
47225799	47225822	X	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.2640886355060397	[3]	[3,1]	-5	hSpCas9	positive selection	4262440
47225076	47225099	X	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.2834941935989723	[2]	[2,1]	6	hSpCas9	positive selection	4262441
47225091	47225114	X	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	-0.16396211380882364	[1]	[1,0]	-3	hSpCas9	positive selection	4262442
47224854	47224877	X	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.022227204275679147	[2]	[2,1]	0	hSpCas9	positive selection	4326718
47224862	47224885	X	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.4189383434981745	[3]	[3,3]	8	hSpCas9	positive selection	4326719
47225776	47225799	X	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.0999318092232454	[1]	[0,0]	-2	hSpCas9	positive selection	4326720
47224468	47224490	X	-	27760321	OCIAML3	viability	TGCGCATACGCACTCTCACTGG	CDK16	ENSG00000102225	-0.20963896973822405	[298,275]	[114,297]	-2	hSpCas9	negative selection	4388016
47224511	47224533	X	-	27760321	OCIAML3	viability	ACGGGGTCAAGCACCTCAGTGG	CDK16	ENSG00000102225	0.7239847563836646	[640,495]	[607,886]	8	hSpCas9	negative selection	4388017
47224635	47224657	X	+	27760321	OCIAML3	viability	ATCACTACCAGCTGACATCCGG	CDK16	ENSG00000102225	0.08703756578684524	[629,523]	[465,491]	1	hSpCas9	negative selection	4388018
47224823	47224845	X	+	27760321	OCIAML3	viability	TTGTCCCACAGTCTGAGATTGG	CDK16	ENSG00000102225	0.6602858841763775	[386,392]	[466,505]	7	hSpCas9	negative selection	4388019
47225091	47225113	X	-	27760321	OCIAML3	viability	GGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.3836380013356722	[386,315]	[289,443]	4	hSpCas9	negative selection	4388020
47224468	47224490	X	-	27760321	OCIAML2	viability	TGCGCATACGCACTCTCACTGG	CDK16	ENSG00000102225	0.5024341017396468	[298,275]	[281,391]	7	hSpCas9	negative selection	4471479
47224511	47224533	X	-	27760321	OCIAML2	viability	ACGGGGTCAAGCACCTCAGTGG	CDK16	ENSG00000102225	0.676066131011759	[640,495]	[672,803]	8	hSpCas9	negative selection	4471480
47224635	47224657	X	+	27760321	OCIAML2	viability	ATCACTACCAGCTGACATCCGG	CDK16	ENSG00000102225	0.09074415547770392	[629,523]	[396,623]	1	hSpCas9	negative selection	4471481
47224823	47224845	X	+	27760321	OCIAML2	viability	TTGTCCCACAGTCTGAGATTGG	CDK16	ENSG00000102225	0.0825111945888812	[386,392]	[280,406]	1	hSpCas9	negative selection	4471482
47225091	47225113	X	-	27760321	OCIAML2	viability	GGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.1670908040649258	[386,315]	[261,390]	2	hSpCas9	negative selection	4471483
47224468	47224490	X	-	27760321	MV411	viability	TGCGCATACGCACTCTCACTGG	CDK16	ENSG00000102225	-1.7401066782849801	[298,275]	[47,69]	-8	hSpCas9	negative selection	4554942
47224511	47224533	X	-	27760321	MV411	viability	ACGGGGTCAAGCACCTCAGTGG	CDK16	ENSG00000102225	0.8419159660028503	[640,495]	[191,1381]	6	hSpCas9	negative selection	4554943
47224635	47224657	X	+	27760321	MV411	viability	ATCACTACCAGCTGACATCCGG	CDK16	ENSG00000102225	0.09258669550308013	[629,523]	[490,273]	0	hSpCas9	negative selection	4554944
47224823	47224845	X	+	27760321	MV411	viability	TTGTCCCACAGTCTGAGATTGG	CDK16	ENSG00000102225	1.4298189715176797	[386,392]	[791,551]	9	hSpCas9	negative selection	4554945
47225091	47225113	X	-	27760321	MV411	viability	GGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.7725494947186794	[386,315]	[227,643]	5	hSpCas9	negative selection	4554946
47224468	47224490	X	-	27760321	HL60	viability	TGCGCATACGCACTCTCACTGG	CDK16	ENSG00000102225	0.7087230579444124	[298,275]	[427,336]	7	hSpCas9	negative selection	4638405
47224511	47224533	X	-	27760321	HL60	viability	ACGGGGTCAAGCACCTCAGTGG	CDK16	ENSG00000102225	0.021855540527702888	[640,495]	[520,411]	0	hSpCas9	negative selection	4638406
47224635	47224657	X	+	27760321	HL60	viability	ATCACTACCAGCTGACATCCGG	CDK16	ENSG00000102225	-0.15505554438951236	[629,523]	[371,473]	-2	hSpCas9	negative selection	4638407
47224823	47224845	X	+	27760321	HL60	viability	TTGTCCCACAGTCTGAGATTGG	CDK16	ENSG00000102225	0.34956322830337067	[386,392]	[374,441]	4	hSpCas9	negative selection	4638408
47225091	47225113	X	-	27760321	HL60	viability	GGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	-0.08180668103426725	[386,315]	[350,183]	-1	hSpCas9	negative selection	4638409
47224468	47224490	X	-	27760321	HT1080	viability	TGCGCATACGCACTCTCACTGG	CDK16	ENSG00000102225	0.5398579000467237	[275,215]	[152,130]	3	hSpCas9	negative selection	4721868
47224511	47224533	X	-	27760321	HT1080	viability	ACGGGGTCAAGCACCTCAGTGG	CDK16	ENSG00000102225	-2.150516400169261	[495,386]	[41,36]	-6	hSpCas9	negative selection	4721869
47224635	47224657	X	+	27760321	HT1080	viability	ATCACTACCAGCTGACATCCGG	CDK16	ENSG00000102225	-1.0841589758932326	[523,408]	[111,60]	-4	hSpCas9	negative selection	4721870
47224823	47224845	X	+	27760321	HT1080	viability	TTGTCCCACAGTCTGAGATTGG	CDK16	ENSG00000102225	-0.6162327701668271	[392,306]	[26,160]	-3	hSpCas9	negative selection	4721871
47225091	47225113	X	-	27760321	HT1080	viability	GGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	-5.5271329031941026	[315,246]	[0,3]	-8	hSpCas9	negative selection	4721872
47224468	47224490	X	-	27760321	HT29	viability after 7 days	TGCGCATACGCACTCTCACTGG	CDK16	ENSG00000102225	0.05731683383320951	[275,215]	[310,203,464]	0	hSpCas9	negative selection	4805331
47224511	47224533	X	-	27760321	HT29	viability after 7 days	ACGGGGTCAAGCACCTCAGTGG	CDK16	ENSG00000102225	0.42270280177582703	[495,386]	[769,852,662]	6	hSpCas9	negative selection	4805332
47224635	47224657	X	+	27760321	HT29	viability after 7 days	ATCACTACCAGCTGACATCCGG	CDK16	ENSG00000102225	-0.08267675255668744	[523,408]	[702,549,467]	-1	hSpCas9	negative selection	4805333
47224823	47224845	X	+	27760321	HT29	viability after 7 days	TTGTCCCACAGTCTGAGATTGG	CDK16	ENSG00000102225	-0.26594903891845517	[392,306]	[271,471,363]	-4	hSpCas9	negative selection	4805334
47225091	47225113	X	-	27760321	HT29	viability after 7 days	GGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	-0.05288969957880674	[315,246]	[258,505,270]	-1	hSpCas9	negative selection	4805335
47224468	47224490	X	-	27760321	HT29	viability after 25 days	TGCGCATACGCACTCTCACTGG	CDK16	ENSG00000102225	-0.04418899863136316	[275,215]	[164,364,296]	0	hSpCas9	negative selection	4888794
47224511	47224533	X	-	27760321	HT29	viability after 25 days	ACGGGGTCAAGCACCTCAGTGG	CDK16	ENSG00000102225	0.45909520015213107	[495,386]	[751,604,721]	5	hSpCas9	negative selection	4888795
47224635	47224657	X	+	27760321	HT29	viability after 25 days	ATCACTACCAGCTGACATCCGG	CDK16	ENSG00000102225	0.08506392573376076	[523,408]	[412,530,783]	0	hSpCas9	negative selection	4888796
47224823	47224845	X	+	27760321	HT29	viability after 25 days	TTGTCCCACAGTCTGAGATTGG	CDK16	ENSG00000102225	0.2317230547958789	[392,306]	[605,313,480]	2	hSpCas9	negative selection	4888797
47225091	47225113	X	-	27760321	HT29	viability after 25 days	GGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	-0.7706722516546431	[315,246]	[187,175,202]	-6	hSpCas9	negative selection	4888798
47224468	47224490	X	-	27760321	HT29	viability after 22 days	TGCGCATACGCACTCTCACTGG	CDK16	ENSG00000102225	-0.2663328071643848	[275,215]	[126,287,297]	-3	hSpCas9	negative selection	4972257
47224511	47224533	X	-	27760321	HT29	viability after 22 days	ACGGGGTCAAGCACCTCAGTGG	CDK16	ENSG00000102225	0.439316307622797	[495,386]	[908,500,659]	5	hSpCas9	negative selection	4972258
47224635	47224657	X	+	27760321	HT29	viability after 22 days	ATCACTACCAGCTGACATCCGG	CDK16	ENSG00000102225	0.06120338261809333	[523,408]	[361,602,729]	0	hSpCas9	negative selection	4972259
47224823	47224845	X	+	27760321	HT29	viability after 22 days	TTGTCCCACAGTCTGAGATTGG	CDK16	ENSG00000102225	0.017782410620903612	[392,306]	[372,441,414]	0	hSpCas9	negative selection	4972260
47225091	47225113	X	-	27760321	HT29	viability after 22 days	GGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	-0.35058049686340814	[315,246]	[197,342,225]	-3	hSpCas9	negative selection	4972261
47224468	47224490	X	-	27760321	HT29	viability after 19 days	TGCGCATACGCACTCTCACTGG	CDK16	ENSG00000102225	0.42071111458469523	[275,215]	[159,648,300]	4	hSpCas9	negative selection	5055720
47224511	47224533	X	-	27760321	HT29	viability after 19 days	ACGGGGTCAAGCACCTCAGTGG	CDK16	ENSG00000102225	0.702528007552587	[495,386]	[641,855,942]	7	hSpCas9	negative selection	5055721
47224635	47224657	X	+	27760321	HT29	viability after 19 days	ATCACTACCAGCTGACATCCGG	CDK16	ENSG00000102225	0.08640460103977132	[523,408]	[562,471,659]	0	hSpCas9	negative selection	5055722
47224823	47224845	X	+	27760321	HT29	viability after 19 days	TTGTCCCACAGTCTGAGATTGG	CDK16	ENSG00000102225	0.4920247716798034	[392,306]	[659,588,453]	5	hSpCas9	negative selection	5055723
47225091	47225113	X	-	27760321	HT29	viability after 19 days	GGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	-0.08557773252519724	[315,246]	[249,176,470]	-1	hSpCas9	negative selection	5055724
47224468	47224490	X	-	27760321	HT29	viability after 16 days	TGCGCATACGCACTCTCACTGG	CDK16	ENSG00000102225	0.200507507736792	[275,215]	[128,438,359]	2	hSpCas9	negative selection	5139183
47224511	47224533	X	-	27760321	HT29	viability after 16 days	ACGGGGTCAAGCACCTCAGTGG	CDK16	ENSG00000102225	0.16102811797193317	[495,386]	[581,495,582]	1	hSpCas9	negative selection	5139184
47224635	47224657	X	+	27760321	HT29	viability after 16 days	ATCACTACCAGCTGACATCCGG	CDK16	ENSG00000102225	0.12589699778478053	[523,408]	[501,610,587]	1	hSpCas9	negative selection	5139185
47224823	47224845	X	+	27760321	HT29	viability after 16 days	TTGTCCCACAGTCTGAGATTGG	CDK16	ENSG00000102225	0.42081351911828163	[392,306]	[610,516,452]	5	hSpCas9	negative selection	5139186
47225091	47225113	X	-	27760321	HT29	viability after 16 days	GGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	-0.17511424936613335	[315,246]	[382,228,235]	-2	hSpCas9	negative selection	5139187
47224468	47224490	X	-	27760321	HT29	viability after 13 days	TGCGCATACGCACTCTCACTGG	CDK16	ENSG00000102225	-0.17424560411404544	[275,215]	[153,367,237]	-2	hSpCas9	negative selection	5222646
47224511	47224533	X	-	27760321	HT29	viability after 13 days	ACGGGGTCAAGCACCTCAGTGG	CDK16	ENSG00000102225	0.42807341094296375	[495,386]	[831,769,477]	5	hSpCas9	negative selection	5222647
47224635	47224657	X	+	27760321	HT29	viability after 13 days	ATCACTACCAGCTGACATCCGG	CDK16	ENSG00000102225	0.2254899516246473	[523,408]	[486,872,543]	3	hSpCas9	negative selection	5222648
47224823	47224845	X	+	27760321	HT29	viability after 13 days	TTGTCCCACAGTCTGAGATTGG	CDK16	ENSG00000102225	0.2515154358952762	[392,306]	[560,423,465]	3	hSpCas9	negative selection	5222649
47225091	47225113	X	-	27760321	HT29	viability after 13 days	GGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	-0.3846379098210155	[315,246]	[187,199,355]	-4	hSpCas9	negative selection	5222650
47224468	47224490	X	-	27760321	HT29	viability after 10 days	TGCGCATACGCACTCTCACTGG	CDK16	ENSG00000102225	0.12852683264880604	[275,215]	[118,564,329]	1	hSpCas9	negative selection	5306109
47224511	47224533	X	-	27760321	HT29	viability after 10 days	ACGGGGTCAAGCACCTCAGTGG	CDK16	ENSG00000102225	0.30449216843097965	[495,386]	[735,712,595]	4	hSpCas9	negative selection	5306110
47224635	47224657	X	+	27760321	HT29	viability after 10 days	ATCACTACCAGCTGACATCCGG	CDK16	ENSG00000102225	0.2741591430923211	[523,408]	[661,583,859]	3	hSpCas9	negative selection	5306111
47224823	47224845	X	+	27760321	HT29	viability after 10 days	TTGTCCCACAGTCTGAGATTGG	CDK16	ENSG00000102225	-0.9144217551904518	[392,306]	[253,250,191]	-7	hSpCas9	negative selection	5306112
47225091	47225113	X	-	27760321	HT29	viability after 10 days	GGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	-0.13561061229377075	[315,246]	[261,348,348]	-2	hSpCas9	negative selection	5306113
47224468	47224490	X	-	27760321	MOLM13	viability	TGCGCATACGCACTCTCACTGG	CDK16	ENSG00000102225	0.4912700015766052	[298,275]	[126,313]	3	hSpCas9	negative selection	5389572
47224511	47224533	X	-	27760321	MOLM13	viability	ACGGGGTCAAGCACCTCAGTGG	CDK16	ENSG00000102225	0.10544500651213051	[640,495]	[253,417]	0	hSpCas9	negative selection	5389573
47224635	47224657	X	+	27760321	MOLM13	viability	ATCACTACCAGCTGACATCCGG	CDK16	ENSG00000102225	-0.19399831045895521	[629,523]	[385,195]	-1	hSpCas9	negative selection	5389574
47224823	47224845	X	+	27760321	MOLM13	viability	TTGTCCCACAGTCTGAGATTGG	CDK16	ENSG00000102225	0.5489198118926963	[386,392]	[219,410]	4	hSpCas9	negative selection	5389575
47225091	47225113	X	-	27760321	MOLM13	viability	GGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.8260447858152411	[386,315]	[432,278]	6	hSpCas9	negative selection	5389576
47218554	47218577	X	-	27661255	K562	viability	GACGGCACCAGGGAGAACTGTGG	CDK16	ENSG00000102225	0.1707670128940593	[732,783]	[806,573]	6	dCas9-KRAB	negative selection	5469883
47218779	47218802	X	-	27661255	K562	viability	GGCACAGAGCGGTCTGATCGCGG	CDK16	ENSG00000102225	0.36465716497377304	[648,767]	[854,616]	9	dCas9-KRAB	negative selection	5469884
47219168	47219191	X	-	27661255	K562	viability	GCCCCGCAGCCCAGACCCCTGGG	CDK16	ENSG00000102225	0.1800270318446191	[1005,1230]	[1014,1002]	6	dCas9-KRAB	negative selection	5469885
47225799	47225822	X	-	27260156	BXPC3	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.07043465312433173	[893]	[795,851,887,1050]	-2	hSpCas9	negative selection	5534900
47225076	47225099	X	+	27260156	BXPC3	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.5233763873225393	[201]	[269,248,387,314]	9	hSpCas9	negative selection	5534901
47225091	47225114	X	-	27260156	BXPC3	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.10520262938894609	[167]	[126,165,226,250]	2	hSpCas9	negative selection	5534902
47224854	47224877	X	+	27260156	BXPC3	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.050301555249928354	[392]	[451,326,417,515]	1	hSpCas9	negative selection	5599178
47224862	47224885	X	-	27260156	BXPC3	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.15417275536815955	[782]	[857,800,967,1039]	3	hSpCas9	negative selection	5599179
47225776	47225799	X	-	27260156	BXPC3	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.6214020107420901	[112]	[54,71,71,114]	-8	hSpCas9	negative selection	5599180
47225799	47225822	X	-	27260156	A673	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.544107517259378	[893]	[804,635,724,790]	-8	hSpCas9	negative selection	5656151
47225076	47225099	X	+	27260156	A673	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.5766838882878924	[201]	[431,255,314,459]	9	hSpCas9	negative selection	5656152
47225091	47225114	X	-	27260156	A673	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.26693957613737007	[167]	[331,261,174,209]	6	hSpCas9	negative selection	5656153
47224854	47224877	X	+	27260156	A673	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.13295344088541944	[392]	[436,312,430,549]	-3	hSpCas9	negative selection	5720429
47224862	47224885	X	-	27260156	A673	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.013340916099548683	[782]	[997,905,865,964]	0	hSpCas9	negative selection	5720430
47225776	47225799	X	-	27260156	A673	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.40835507525711456	[112]	[144,76,81,110]	-7	hSpCas9	negative selection	5720431
47225799	47225822	X	-	27260156	A375	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.4596658896519319	[893]	[527,1010,847,688]	-6	hSpCas9	negative selection	5777402
47225076	47225099	X	+	27260156	A375	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.7838529768277525	[201]	[523,379,388,335]	9	hSpCas9	negative selection	5777403
47225091	47225114	X	-	27260156	A375	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.5485373297077831	[167]	[216,247,287,376]	7	hSpCas9	negative selection	5777404
47224854	47224877	X	+	27260156	A375	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.25674840480748135	[392]	[438,635,579,547]	4	hSpCas9	negative selection	5841680
47224862	47224885	X	-	27260156	A375	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.20317698132914352	[782]	[617,1367,1052,1191]	3	hSpCas9	negative selection	5841681
47225776	47225799	X	-	27260156	A375	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.3585271503571339	[112]	[137,157,63,63]	-5	hSpCas9	negative selection	5841682
47225799	47225822	X	-	27260156	COLO741	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.12135517275410501	[893]	[1220,958,986]	-3	hSpCas9	negative selection	5898653
47225076	47225099	X	+	27260156	COLO741	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.2188367478282267	[201]	[279,279,335]	4	hSpCas9	negative selection	5898654
47225091	47225114	X	-	27260156	COLO741	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.20134415324394062	[167]	[305,278,165]	4	hSpCas9	negative selection	5898655
47224854	47224877	X	+	27260156	COLO741	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.21271343330174197	[392]	[508,432,780]	4	hSpCas9	negative selection	5962931
47224862	47224885	X	-	27260156	COLO741	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.23719932335557015	[782]	[1320,1244,994]	5	hSpCas9	negative selection	5962932
47225776	47225799	X	-	27260156	COLO741	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.11853371872950591	[112]	[155,200,49]	-3	hSpCas9	negative selection	5962933
47225799	47225822	X	-	27260156	CAL120	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.408124343040673	[893]	[1255,449,870]	-5	hSpCas9	negative selection	6019904
47225076	47225099	X	+	27260156	CAL120	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.4302102662623507	[201]	[415,351,260]	6	hSpCas9	negative selection	6019905
47225091	47225114	X	-	27260156	CAL120	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.18534441359368814	[167]	[430,121,189]	2	hSpCas9	negative selection	6019906
47224854	47224877	X	+	27260156	CAL120	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.42912476126339455	[392]	[357,438,292]	-6	hSpCas9	negative selection	6084182
47224862	47224885	X	-	27260156	CAL120	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.09637606707367341	[782]	[1343,836,989]	1	hSpCas9	negative selection	6084183
47225776	47225799	X	-	27260156	CAL120	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-1.2523738227310184	[112]	[38,73,60]	-9	hSpCas9	negative selection	6084184
47225799	47225822	X	-	27260156	CADOES1	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.9212828362388782	[893]	[401,429,440,484]	-9	hSpCas9	negative selection	6141155
47225076	47225099	X	+	27260156	CADOES1	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.6198315223687376	[201]	[184,196,428,345]	8	hSpCas9	negative selection	6141156
47225091	47225114	X	-	27260156	CADOES1	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.06495140168543467	[167]	[160,148,173,169]	1	hSpCas9	negative selection	6141157
47224854	47224877	X	+	27260156	CADOES1	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.0010208156370112298	[392]	[383,322,359,394]	0	hSpCas9	negative selection	6205433
47224862	47224885	X	-	27260156	CADOES1	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.40525687152292467	[782]	[478,679,440,601]	-6	hSpCas9	negative selection	6205434
47225776	47225799	X	-	27260156	CADOES1	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.5496724150961305	[112]	[72,65,80,66]	-7	hSpCas9	negative selection	6205435
47225799	47225822	X	-	27260156	EWS502	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.5226302112698131	[893]	[487,706,716,747]	-7	hSpCas9	negative selection	6262406
47225076	47225099	X	+	27260156	EWS502	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	1.059145777667364	[201]	[330,365,476,638]	9	hSpCas9	negative selection	6262407
47225091	47225114	X	-	27260156	EWS502	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.4185741875655118	[167]	[212,212,149,387]	7	hSpCas9	negative selection	6262408
47224854	47224877	X	+	27260156	EWS502	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.14572012236455217	[392]	[393,428,503,527]	2	hSpCas9	negative selection	6326684
47224862	47224885	X	-	27260156	EWS502	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.0639823964462155	[782]	[901,610,995,647]	-1	hSpCas9	negative selection	6326685
47225776	47225799	X	-	27260156	EWS502	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.8297896537772127	[112]	[75,97,27,63]	-8	hSpCas9	negative selection	6326686
47225799	47225822	X	-	27260156	EW8	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.8294896409347245	[893]	[454,483,404,291]	-9	hSpCas9	negative selection	6383657
47225076	47225099	X	+	27260156	EW8	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.7232081219685569	[201]	[254,373,283,163]	9	hSpCas9	negative selection	6383658
47225091	47225114	X	-	27260156	EW8	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.2651629810968301	[167]	[273,175,106,118]	5	hSpCas9	negative selection	6383659
47224854	47224877	X	+	27260156	EW8	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.1938875431879857	[392]	[317,646,172,346]	3	hSpCas9	negative selection	6447935
47224862	47224885	X	-	27260156	EW8	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.4582898079001894	[782]	[557,428,369,514]	-7	hSpCas9	negative selection	6447936
47225776	47225799	X	-	27260156	EW8	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.12429523554306288	[112]	[116,98,57,69]	-2	hSpCas9	negative selection	6447937
47225799	47225822	X	-	27260156	CORL105	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.21029971242732037	[893]	[911,824,943,944]	-4	hSpCas9	negative selection	6504908
47225076	47225099	X	+	27260156	CORL105	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.9581190181187611	[201]	[521,442,576,316]	9	hSpCas9	negative selection	6504909
47225091	47225114	X	-	27260156	CORL105	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.2752120802554232	[167]	[194,308,242,202]	5	hSpCas9	negative selection	6504910
47224854	47224877	X	+	27260156	CORL105	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.04281717259369236	[392]	[448,436,628,404]	0	hSpCas9	negative selection	6569186
47224862	47224885	X	-	27260156	CORL105	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.13412376889889033	[782]	[927,894,1179,1046]	2	hSpCas9	negative selection	6569187
47225776	47225799	X	-	27260156	CORL105	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-1.2381219705389515	[112]	[60,47,70,46]	-9	hSpCas9	negative selection	6569188
47225799	47225822	X	-	27260156	HS294T	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	0.007660616027201916	[893]	[275,315,436,371]	0	hSpCas9	negative selection	6626159
47225076	47225099	X	+	27260156	HS294T	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.5552556719720246	[201]	[99,133,107,117]	7	hSpCas9	negative selection	6626160
47225091	47225114	X	-	27260156	HS294T	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.6039012649045254	[167]	[40,66,165,132]	7	hSpCas9	negative selection	6626161
47224854	47224877	X	+	27260156	HS294T	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.002005099212993855	[392]	[118,118,214,160]	0	hSpCas9	negative selection	6690437
47224862	47224885	X	-	27260156	HS294T	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.2388445257523627	[782]	[286,394,390,360]	3	hSpCas9	negative selection	6690438
47225776	47225799	X	-	27260156	HS294T	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-1.3031787956883991	[112]	[7,29,16,15]	-9	hSpCas9	negative selection	6690439
47225799	47225822	X	-	27260156	HCC44	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.37641579872721265	[893]	[704,490,1265,765]	-5	hSpCas9	negative selection	6747410
47225076	47225099	X	+	27260156	HCC44	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.8018951099494562	[201]	[530,151,412,538]	9	hSpCas9	negative selection	6747411
47225091	47225114	X	-	27260156	HCC44	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.06680619832833568	[167]	[212,209,168,196]	1	hSpCas9	negative selection	6747412
47224854	47224877	X	+	27260156	HCC44	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.0462864412150682	[392]	[648,298,603,348]	0	hSpCas9	negative selection	6811688
47224862	47224885	X	-	27260156	HCC44	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.1724139464809319	[782]	[786,794,739,804]	-3	hSpCas9	negative selection	6811689
47225776	47225799	X	-	27260156	HCC44	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.24914226624929592	[112]	[102,76,172,91]	-4	hSpCas9	negative selection	6811690
47225799	47225822	X	-	27260156	G402	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.8243827580819838	[893]	[391,1215,594,277]	-7	hSpCas9	negative selection	6868661
47225076	47225099	X	+	27260156	G402	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.600062312216542	[201]	[383,368,595,155]	7	hSpCas9	negative selection	6868662
47225091	47225114	X	-	27260156	G402	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	-0.2718471879725608	[167]	[377,137,132,62]	-3	hSpCas9	negative selection	6868663
47224854	47224877	X	+	27260156	G402	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.15001650366860841	[392]	[419,486,403,783]	2	hSpCas9	negative selection	6932939
47224862	47224885	X	-	27260156	G402	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.020565304689702746	[782]	[1457,827,612,1032]	0	hSpCas9	negative selection	6932940
47225776	47225799	X	-	27260156	G402	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.8581391371319698	[112]	[60,72,120,47]	-7	hSpCas9	negative selection	6932941
47225799	47225822	X	-	27260156	L33	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.3348494286506609	[893]	[669,329,434,668]	-7	hSpCas9	negative selection	6989912
47225076	47225099	X	+	27260156	L33	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.5216590281724321	[201]	[240,118,191,323]	9	hSpCas9	negative selection	6989913
47225091	47225114	X	-	27260156	L33	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.15678525768202656	[167]	[231,68,119,156]	3	hSpCas9	negative selection	6989914
47224854	47224877	X	+	27260156	L33	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.1527697724723988	[392]	[353,234,260,406]	3	hSpCas9	negative selection	7054190
47224862	47224885	X	-	27260156	L33	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.07222753970646623	[782]	[684,292,495,790]	-2	hSpCas9	negative selection	7054191
47225776	47225799	X	-	27260156	L33	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-1.0136216373500533	[112]	[53,12,45,64]	-9	hSpCas9	negative selection	7054192
47225799	47225822	X	-	27260156	K562	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.09713166124480743	[893]	[512,765,1149,540]	-1	hSpCas9	negative selection	7111163
47225076	47225099	X	+	27260156	K562	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.9396916629890593	[201]	[389,434,312,254]	9	hSpCas9	negative selection	7111164
47225091	47225114	X	-	27260156	K562	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.32559070731250483	[167]	[235,254,74,187]	4	hSpCas9	negative selection	7111165
47224854	47224877	X	+	27260156	K562	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.1030995322586217	[392]	[468,593,313,163]	1	hSpCas9	negative selection	7175441
47224862	47224885	X	-	27260156	K562	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.0379221754873883	[782]	[711,902,453,652]	0	hSpCas9	negative selection	7175442
47225776	47225799	X	-	27260156	K562	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-1.2287372789862432	[112]	[85,11,51,24]	-8	hSpCas9	negative selection	7175443
47225799	47225822	X	-	27260156	HT29	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.4606581694402519	[893]	[869,817,803,682]	-7	hSpCas9	negative selection	7232414
47225076	47225099	X	+	27260156	HT29	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.449768592768398	[201]	[282,410,396,259]	8	hSpCas9	negative selection	7232415
47225091	47225114	X	-	27260156	HT29	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.3955420453631435	[167]	[383,290,225,191]	7	hSpCas9	negative selection	7232416
47224854	47224877	X	+	27260156	HT29	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.3061531218730878	[392]	[310,480,401,354]	-5	hSpCas9	negative selection	7296692
47224862	47224885	X	-	27260156	HT29	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.00830501324109656	[782]	[978,1188,1051,660]	0	hSpCas9	negative selection	7296693
47225776	47225799	X	-	27260156	HT29	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.21854507433071024	[112]	[76,122,126,138]	-4	hSpCas9	negative selection	7296694
47225799	47225822	X	-	27260156	MHHES1	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.47149596855252274	[893]	[823,927,580,612]	-7	hSpCas9	negative selection	7353665
47225076	47225099	X	+	27260156	MHHES1	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.455848044421144	[201]	[363,342,322,237]	7	hSpCas9	negative selection	7353666
47225091	47225114	X	-	27260156	MHHES1	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.7527546014536396	[167]	[320,457,277,242]	9	hSpCas9	negative selection	7353667
47224854	47224877	X	+	27260156	MHHES1	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.17937525604950255	[392]	[429,638,457,476]	3	hSpCas9	negative selection	7417943
47224862	47224885	X	-	27260156	MHHES1	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.1465380060110446	[782]	[1233,981,1099,670]	2	hSpCas9	negative selection	7417944
47225776	47225799	X	-	27260156	MHHES1	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-1.1636301144307604	[112]	[21,47,98,52]	-9	hSpCas9	negative selection	7417945
47225799	47225822	X	-	27260156	MEWO	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.523871155307382	[893]	[649,425,682]	-8	hSpCas9	negative selection	7474916
47225076	47225099	X	+	27260156	MEWO	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.1714253225079836	[201]	[307,186,161]	4	hSpCas9	negative selection	7474917
47225091	47225114	X	-	27260156	MEWO	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.5358510200404328	[167]	[249,196,240]	9	hSpCas9	negative selection	7474918
47224854	47224877	X	+	27260156	MEWO	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.16875705315453604	[392]	[402,305,286]	-4	hSpCas9	negative selection	7539194
47224862	47224885	X	-	27260156	MEWO	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.14178521080859363	[782]	[797,895,727]	3	hSpCas9	negative selection	7539195
47225776	47225799	X	-	27260156	MEWO	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.46898486206944234	[112]	[120,27,88]	-7	hSpCas9	negative selection	7539196
47225799	47225822	X	-	27260156	LNCAPCLONEFGC	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.28684013947325515	[893]	[647,626,686,698]	-4	hSpCas9	negative selection	7596167
47225076	47225099	X	+	27260156	LNCAPCLONEFGC	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.7161647095072942	[201]	[343,204,396,275]	9	hSpCas9	negative selection	7596168
47225091	47225114	X	-	27260156	LNCAPCLONEFGC	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.17085551358259288	[167]	[147,137,239,171]	2	hSpCas9	negative selection	7596169
47224854	47224877	X	+	27260156	LNCAPCLONEFGC	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.3562470255925839	[392]	[412,514,391,489]	5	hSpCas9	negative selection	7660445
47224862	47224885	X	-	27260156	LNCAPCLONEFGC	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.40205071411611326	[782]	[829,911,956,1055]	6	hSpCas9	negative selection	7660446
47225776	47225799	X	-	27260156	LNCAPCLONEFGC	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.5550045267283887	[112]	[78,116,26,45]	-7	hSpCas9	negative selection	7660447
47225799	47225822	X	-	27260156	PANC0327	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.024286763308931092	[893]	[745,689,734,960]	0	hSpCas9	negative selection	7717418
47225076	47225099	X	+	27260156	PANC0327	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.5153220570179124	[201]	[158,395,316,127]	7	hSpCas9	negative selection	7717419
47225091	47225114	X	-	27260156	PANC0327	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.3837167806164148	[167]	[158,271,235,98]	5	hSpCas9	negative selection	7717420
47224854	47224877	X	+	27260156	PANC0327	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.07623845975923788	[392]	[583,358,330,216]	1	hSpCas9	negative selection	7781696
47224862	47224885	X	-	27260156	PANC0327	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.020969445861057312	[782]	[667,647,602,825]	0	hSpCas9	negative selection	7781697
47225776	47225799	X	-	27260156	PANC0327	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	0.010853686136760743	[112]	[91,19,26,274]	0	hSpCas9	negative selection	7781698
47225799	47225822	X	-	27260156	NCIH2009	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.03878001716469093	[893]	[1434,941,1316]	0	hSpCas9	negative selection	7838669
47225076	47225099	X	+	27260156	NCIH2009	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	1.250529620918731	[201]	[596,815,582]	9	hSpCas9	negative selection	7838670
47225091	47225114	X	-	27260156	NCIH2009	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.382419388228725	[167]	[338,300,283]	5	hSpCas9	negative selection	7838671
47224854	47224877	X	+	27260156	NCIH2009	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.017867092330657003	[392]	[783,495,432]	0	hSpCas9	negative selection	7902947
47224862	47224885	X	-	27260156	NCIH2009	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.13535962089877773	[782]	[1553,1221,895]	1	hSpCas9	negative selection	7902948
47225776	47225799	X	-	27260156	NCIH2009	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.2186715957356471	[112]	[109,64,227]	-3	hSpCas9	negative selection	7902949
47225799	47225822	X	-	27260156	NCIH1373	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.2711251159619543	[893]	[1412,373,665,267]	-3	hSpCas9	negative selection	7959920
47225076	47225099	X	+	27260156	NCIH1373	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	1.78091305864527	[201]	[797,784,929,152]	9	hSpCas9	negative selection	7959921
47225091	47225114	X	-	27260156	NCIH1373	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.014917215680764873	[167]	[381,109,138,43]	0	hSpCas9	negative selection	7959922
47224854	47224877	X	+	27260156	NCIH1373	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.6029760334280811	[392]	[1140,505,626,125]	6	hSpCas9	negative selection	8024198
47224862	47224885	X	-	27260156	NCIH1373	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.25831938742752847	[782]	[1349,1063,758,281]	2	hSpCas9	negative selection	8024199
47225776	47225799	X	-	27260156	NCIH1373	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-1.5731557191510537	[112]	[52,35,51,7]	-9	hSpCas9	negative selection	8024200
47225799	47225822	X	-	27260156	PATU8902	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	0.1682758710657143	[893]	[887,2207,1038,1573]	1	hSpCas9	negative selection	8081171
47225076	47225099	X	+	27260156	PATU8902	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	1.429874790066748	[201]	[580,855,821,751]	9	hSpCas9	negative selection	8081172
47225091	47225114	X	-	27260156	PATU8902	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.501155419582941	[167]	[351,235,96,746]	5	hSpCas9	negative selection	8081173
47224854	47224877	X	+	27260156	PATU8902	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.02443832148727698	[392]	[458,610,519,654]	0	hSpCas9	negative selection	8145449
47224862	47224885	X	-	27260156	PATU8902	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.8222836373145689	[782]	[2002,1685,1644,2503]	8	hSpCas9	negative selection	8145450
47225776	47225799	X	-	27260156	PATU8902	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	0.7841542257694332	[112]	[333,97,256,411]	8	hSpCas9	negative selection	8145451
47225799	47225822	X	-	27260156	PANC1	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.3098165860370594	[893]	[650,615,739,482]	-5	hSpCas9	negative selection	8202422
47225076	47225099	X	+	27260156	PANC1	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.6983397167209006	[201]	[300,334,237,260]	9	hSpCas9	negative selection	8202423
47225091	47225114	X	-	27260156	PANC1	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.26904269631672406	[167]	[185,228,152,140]	4	hSpCas9	negative selection	8202424
47224854	47224877	X	+	27260156	PANC1	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.19938766801569885	[392]	[376,273,163,340]	-3	hSpCas9	negative selection	8266700
47224862	47224885	X	-	27260156	PANC1	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.07970925294679776	[782]	[422,1088,646,748]	1	hSpCas9	negative selection	8266701
47225776	47225799	X	-	27260156	PANC1	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	0.06782216041701061	[112]	[100,174,69,77]	1	hSpCas9	negative selection	8266702
47225799	47225822	X	-	27260156	PANC0813	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	0.15326843430549408	[893]	[1219,1074,1271,1110]	2	hSpCas9	negative selection	8323673
47225076	47225099	X	+	27260156	PANC0813	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.544278222911521	[201]	[369,220,203,576]	8	hSpCas9	negative selection	8323674
47225091	47225114	X	-	27260156	PANC0813	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.34169791763311474	[167]	[352,265,244,150]	5	hSpCas9	negative selection	8323675
47224854	47224877	X	+	27260156	PANC0813	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.005879360731084138	[392]	[696,460,408,315]	0	hSpCas9	negative selection	8387951
47224862	47224885	X	-	27260156	PANC0813	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.22297724866503232	[782]	[1178,1120,1062,945]	3	hSpCas9	negative selection	8387952
47225776	47225799	X	-	27260156	PANC0813	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.26184355179255725	[112]	[142,51,74,171]	-4	hSpCas9	negative selection	8387953
47225799	47225822	X	-	27260156	RDES	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.32315840601783463	[893]	[667,754,789,1135]	-5	hSpCas9	negative selection	8444924
47225076	47225099	X	+	27260156	RDES	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.5936103602562944	[201]	[261,308,447,408]	8	hSpCas9	negative selection	8444925
47225091	47225114	X	-	27260156	RDES	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.30776089424946607	[167]	[269,173,210,300]	5	hSpCas9	negative selection	8444926
47224854	47224877	X	+	27260156	RDES	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.008790474315636232	[392]	[385,474,446,491]	0	hSpCas9	negative selection	8509202
47224862	47224885	X	-	27260156	RDES	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.026658552791164802	[782]	[725,749,1089,1018]	0	hSpCas9	negative selection	8509203
47225776	47225799	X	-	27260156	RDES	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.5178367597210567	[112]	[58,116,90,98]	-7	hSpCas9	negative selection	8509204
47225799	47225822	X	-	27260156	PC3	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.357621006362834	[893]	[394,713,1329,656]	-7	hSpCas9	negative selection	8566175
47225076	47225099	X	+	27260156	PC3	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.5614435966247572	[201]	[191,211,209,573]	9	hSpCas9	negative selection	8566176
47225091	47225114	X	-	27260156	PC3	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.302031771028205	[167]	[129,231,299,211]	6	hSpCas9	negative selection	8566177
47224854	47224877	X	+	27260156	PC3	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.2392160621869926	[392]	[236,526,294,241]	-5	hSpCas9	negative selection	8630453
47224862	47224885	X	-	27260156	PC3	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.02528019498061418	[782]	[396,886,1491,660]	0	hSpCas9	negative selection	8630454
47225776	47225799	X	-	27260156	PC3	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.05917904069332591	[112]	[73,66,178,147]	-1	hSpCas9	negative selection	8630455
47225799	47225822	X	-	27260156	PATU8988T	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.2266338335174799	[893]	[870,713,572,799]	-4	hSpCas9	negative selection	8687426
47225076	47225099	X	+	27260156	PATU8988T	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	-0.20795910221667468	[201]	[121,116,239,192]	-4	hSpCas9	negative selection	8687427
47225091	47225114	X	-	27260156	PATU8988T	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.5557991824590208	[167]	[195,194,253,310]	8	hSpCas9	negative selection	8687428
47224854	47224877	X	+	27260156	PATU8988T	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.20605418262063163	[392]	[346,422,426,563]	3	hSpCas9	negative selection	8751704
47224862	47224885	X	-	27260156	PATU8988T	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.4458966098075555	[782]	[1217,1136,810,963]	7	hSpCas9	negative selection	8751705
47225776	47225799	X	-	27260156	PATU8988T	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.4933050522659328	[112]	[126,92,49,38]	-7	hSpCas9	negative selection	8751706
47225799	47225822	X	-	27260156	T47D	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.4715351849496482	[893]	[737,610,747,924]	-7	hSpCas9	negative selection	8808677
47225076	47225099	X	+	27260156	T47D	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.42372492540039663	[201]	[308,284,325,345]	8	hSpCas9	negative selection	8808678
47225091	47225114	X	-	27260156	T47D	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.5953663764573657	[167]	[288,327,293,267]	9	hSpCas9	negative selection	8808679
47224854	47224877	X	+	27260156	T47D	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.018122046959491156	[392]	[456,444,412,495]	0	hSpCas9	negative selection	8872955
47224862	47224885	X	-	27260156	T47D	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.1136659275840941	[782]	[1046,812,1030,1073]	2	hSpCas9	negative selection	8872956
47225776	47225799	X	-	27260156	T47D	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.03204685990609901	[112]	[171,93,148,101]	0	hSpCas9	negative selection	8872957
47225799	47225822	X	-	27260156	SU8686	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.04713885778827398	[893]	[817,747,809,1106]	-1	hSpCas9	negative selection	8929928
47225076	47225099	X	+	27260156	SU8686	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.5568688001555026	[201]	[273,271,272,374]	8	hSpCas9	negative selection	8929929
47225091	47225114	X	-	27260156	SU8686	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.17771713259233968	[167]	[168,173,146,279]	3	hSpCas9	negative selection	8929930
47224854	47224877	X	+	27260156	SU8686	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.08311002272126197	[392]	[383,406,348,528]	1	hSpCas9	negative selection	8994206
47224862	47224885	X	-	27260156	SU8686	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.18747039802412513	[782]	[826,723,858,1196]	3	hSpCas9	negative selection	8994207
47225776	47225799	X	-	27260156	SU8686	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-1.331993255480508	[112]	[38,33,69,35]	-9	hSpCas9	negative selection	8994208
47225799	47225822	X	-	27260156	SKES1	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.4342009588051421	[893]	[738,739,645,542]	-7	hSpCas9	negative selection	9051179
47225076	47225099	X	+	27260156	SKES1	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.3582488719122817	[201]	[288,192,218,318]	7	hSpCas9	negative selection	9051180
47225091	47225114	X	-	27260156	SKES1	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.3152121774480925	[167]	[254,323,148,133]	6	hSpCas9	negative selection	9051181
47224854	47224877	X	+	27260156	SKES1	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.16062602646794039	[392]	[347,347,367,335]	-4	hSpCas9	negative selection	9115457
47224862	47224885	X	-	27260156	SKES1	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.1137428070329417	[782]	[944,782,966,698]	2	hSpCas9	negative selection	9115458
47225776	47225799	X	-	27260156	SKES1	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.4886657800456913	[112]	[73,74,111,59]	-8	hSpCas9	negative selection	9115459
47225799	47225822	X	-	27260156	TOV112D	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.13649378523442868	[893]	[750,1129,627,819]	-3	hSpCas9	negative selection	9172430
47225076	47225099	X	+	27260156	TOV112D	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.5675870045027666	[201]	[328,279,235,349]	8	hSpCas9	negative selection	9172431
47225091	47225114	X	-	27260156	TOV112D	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.14325767531687106	[167]	[115,194,228,198]	2	hSpCas9	negative selection	9172432
47224854	47224877	X	+	27260156	TOV112D	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.3656713630582426	[392]	[254,203,492,241]	-6	hSpCas9	negative selection	9236708
47224862	47224885	X	-	27260156	TOV112D	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	0.35535315544726387	[782]	[1029,948,973,1045]	6	hSpCas9	negative selection	9236709
47225776	47225799	X	-	27260156	TOV112D	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.9604530832986229	[112]	[58,73,62,40]	-9	hSpCas9	negative selection	9236710
47225799	47225822	X	-	27260156	TC71	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.399211810532606	[893]	[862,682,599,763]	-8	hSpCas9	negative selection	9293681
47225076	47225099	X	+	27260156	TC71	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.09142549865861249	[201]	[230,207,232,251]	2	hSpCas9	negative selection	9293682
47225091	47225114	X	-	27260156	TC71	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.35655661542719597	[167]	[277,182,261,194]	8	hSpCas9	negative selection	9293683
47224854	47224877	X	+	27260156	TC71	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.012064825320519224	[392]	[381,426,393,472]	0	hSpCas9	negative selection	9357959
47224862	47224885	X	-	27260156	TC71	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.07488753657711877	[782]	[743,940,753,747]	-2	hSpCas9	negative selection	9357960
47225776	47225799	X	-	27260156	TC71	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.7421909673403859	[112]	[68,53,83,82]	-9	hSpCas9	negative selection	9357961
47225799	47225822	X	-	27260156	TC32	viability	GTCATGTAGCGTAACGATGTTGG	CDK16	ENSG00000102225	-0.7659109894786296	[893]	[401,402,663,556]	-9	hSpCas9	negative selection	9414932
47225076	47225099	X	+	27260156	TC32	viability	GGGCACCCTGCACCGCCATCCGG	CDK16	ENSG00000102225	0.5921946653032292	[201]	[194,311,391,244]	8	hSpCas9	negative selection	9414933
47225091	47225114	X	-	27260156	TC32	viability	GGGGTGTGTACCTTCCCGGATGG	CDK16	ENSG00000102225	0.2866883506711957	[167]	[244,130,242,162]	5	hSpCas9	negative selection	9414934
47224854	47224877	X	+	27260156	TC32	viability	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.29378103701150904	[392]	[308,389,721,451]	5	hSpCas9	negative selection	9479210
47224862	47224885	X	-	27260156	TC32	viability	CAGTTTGTCCAGCTTAATGTAGG	CDK16	ENSG00000102225	-0.038557818415423495	[782]	[478,575,981,928]	0	hSpCas9	negative selection	9479211
47225776	47225799	X	-	27260156	TC32	viability	CGTGTTTGAGGTCCTTGAGCAGG	CDK16	ENSG00000102225	-0.197377172541489	[112]	[47,36,137,182]	-4	hSpCas9	negative selection	9479212
47223138	47223161	X	+	27869803	HPAFII	viability after 27 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	0.8578010165973364	[128]	[69,166,NaN]	7	hSpCas9	negative selection	9608830
47223674	47223697	X	+	27869803	HPAFII	viability after 27 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.9514458924447977	[1149]	[1532,865,NaN]	7	hSpCas9	negative selection	9608831
47224377	47224400	X	+	27869803	HPAFII	viability after 27 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	0.054945659708442215	[261]	[177,113,NaN]	0	hSpCas9	negative selection	9608832
47224642	47224665	X	-	27869803	HPAFII	viability after 27 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.44063727216983495	[224]	[177,145,NaN]	3	hSpCas9	negative selection	9608833
47224854	47224877	X	+	27869803	HPAFII	viability after 27 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.5079253250161132	[298]	[211,25,NaN]	-4	hSpCas9	negative selection	9608834
47225041	47225064	X	+	27869803	HPAFII	viability after 27 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	0.8759699962180149	[118]	[44,172,NaN]	7	hSpCas9	negative selection	9608835
47223138	47223161	X	+	27869803	HPAFII	viability after 15 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	0.5577734675375658	[128]	[319,131,NaN]	6	hSpCas9	negative selection	9691279
47223674	47223697	X	+	27869803	HPAFII	viability after 15 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.3975097770854328	[1149]	[2354,1175,NaN]	4	hSpCas9	negative selection	9691280
47224377	47224400	X	+	27869803	HPAFII	viability after 15 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	0.21088512807362908	[261]	[492,221,NaN]	2	hSpCas9	negative selection	9691281
47224642	47224665	X	-	27869803	HPAFII	viability after 15 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.49985852371569284	[224]	[447,275,NaN]	6	hSpCas9	negative selection	9691282
47224854	47224877	X	+	27869803	HPAFII	viability after 15 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.09976997287312034	[298]	[553,213,NaN]	1	hSpCas9	negative selection	9691283
47225041	47225064	X	+	27869803	HPAFII	viability after 15 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	0.3826515420646732	[118]	[220,132,NaN]	4	hSpCas9	negative selection	9691284
47223138	47223161	X	+	27869803	ASPC1	viability after 36 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	0.18216754436525484	[270]	[129,210,7]	1	hSpCas9	negative selection	9773728
47223674	47223697	X	+	27869803	ASPC1	viability after 36 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.1296574231053329	[2658]	[838,1606,658]	1	hSpCas9	negative selection	9773729
47224377	47224400	X	+	27869803	ASPC1	viability after 36 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	0.28846750548855743	[615]	[287,268,236]	3	hSpCas9	negative selection	9773730
47224642	47224665	X	-	27869803	ASPC1	viability after 36 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	-0.6005813177603149	[531]	[168,102,103]	-5	hSpCas9	negative selection	9773731
47224854	47224877	X	+	27869803	ASPC1	viability after 36 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.8345047529561265	[571]	[310,554,225]	7	hSpCas9	negative selection	9773732
47225041	47225064	X	+	27869803	ASPC1	viability after 36 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	-1.473852511114423	[355]	[51,49,34]	-8	hSpCas9	negative selection	9773733
47223138	47223161	X	+	27869803	PATU8988S	viability after 35 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	0.04579682643002203	[301]	[148,101,NaN]	0	hSpCas9	negative selection	9856177
47223674	47223697	X	+	27869803	PATU8988S	viability after 35 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.640523634450711	[2377]	[1280,1705,NaN]	7	hSpCas9	negative selection	9856178
47224377	47224400	X	+	27869803	PATU8988S	viability after 35 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	0.5889075054137083	[652]	[427,362,NaN]	6	hSpCas9	negative selection	9856179
47224642	47224665	X	-	27869803	PATU8988S	viability after 35 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	-0.47045152152114267	[551]	[140,179,NaN]	-5	hSpCas9	negative selection	9856180
47224854	47224877	X	+	27869803	PATU8988S	viability after 35 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.08108460462898079	[519]	[190,204,NaN]	-1	hSpCas9	negative selection	9856181
47225041	47225064	X	+	27869803	PATU8988S	viability after 35 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	-0.888582705735644	[330]	[74,68,NaN]	-7	hSpCas9	negative selection	9856182
47223138	47223161	X	+	27869803	PATU8988S	viability after 31 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	-0.09126650925967517	[301]	[105,121,NaN]	-1	hSpCas9	negative selection	9938626
47223674	47223697	X	+	27869803	PATU8988S	viability after 31 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.4266280315566484	[2377]	[1083,1516,NaN]	5	hSpCas9	negative selection	9938627
47224377	47224400	X	+	27869803	PATU8988S	viability after 31 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	0.5334887423756034	[652]	[375,377,NaN]	6	hSpCas9	negative selection	9938628
47224642	47224665	X	-	27869803	PATU8988S	viability after 31 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	-0.36324851264220753	[551]	[138,211,NaN]	-4	hSpCas9	negative selection	9938629
47224854	47224877	X	+	27869803	PATU8988S	viability after 31 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	-0.5096656394972618	[519]	[131,162,NaN]	-5	hSpCas9	negative selection	9938630
47225041	47225064	X	+	27869803	PATU8988S	viability after 31 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	0.013691714528907828	[330]	[145,116,NaN]	0	hSpCas9	negative selection	9938631
47223138	47223161	X	+	27869803	HPAFII	viability after 35 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	0.29897741035634073	[128]	[61,100,NaN]	2	hSpCas9	negative selection	10021075
47223674	47223697	X	+	27869803	HPAFII	viability after 35 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	1.1424937211599597	[1149]	[1296,1271,NaN]	7	hSpCas9	negative selection	10021076
47224377	47224400	X	+	27869803	HPAFII	viability after 35 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	0.4368708707737553	[261]	[211,142,NaN]	3	hSpCas9	negative selection	10021077
47224642	47224665	X	-	27869803	HPAFII	viability after 35 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.43030933197897026	[224]	[192,108,NaN]	2	hSpCas9	negative selection	10021078
47224854	47224877	X	+	27869803	HPAFII	viability after 35 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.8990530146965505	[298]	[484,53,NaN]	6	hSpCas9	negative selection	10021079
47225041	47225064	X	+	27869803	HPAFII	viability after 35 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	1.0545597103720166	[118]	[31,229,NaN]	7	hSpCas9	negative selection	10021080
47223138	47223161	X	+	27869803	HPAFII	viability after 31 days	TCAATTCTGGGCACACGCCCTGG	CDK16	ENSG00000102225	0.9176916716347827	[128]	[97,178,NaN]	7	hSpCas9	negative selection	10103524
47223674	47223697	X	+	27869803	HPAFII	viability after 31 days	TGGCGGCAGTGACCCTGGAGAGG	CDK16	ENSG00000102225	0.8417431672528366	[1149]	[1160,1151,NaN]	6	hSpCas9	negative selection	10103525
47224377	47224400	X	+	27869803	HPAFII	viability after 31 days	GCCACCAGAGATTGTGCACGAGG	CDK16	ENSG00000102225	-0.047622081563835	[261]	[203,74,NaN]	0	hSpCas9	negative selection	10103526
47224642	47224665	X	-	27869803	HPAFII	viability after 31 days	TCAGGCAGCCGGATGTCAGCTGG	CDK16	ENSG00000102225	0.5409661049803306	[224]	[210,153,NaN]	4	hSpCas9	negative selection	10103527
47224854	47224877	X	+	27869803	HPAFII	viability after 31 days	ACTGGAGACCTACATTAAGCTGG	CDK16	ENSG00000102225	0.372487021834434	[298]	[322,101,NaN]	2	hSpCas9	negative selection	10103528
47225041	47225064	X	+	27869803	HPAFII	viability after 31 days	GGCACTCAAGGAGATCAGACTGG	CDK16	ENSG00000102225	0.31123196922631113	[118]	[23,146,NaN]	2	hSpCas9	negative selection	10103529
47228589	47228612	X	+	28162770	P31FUJ	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	0.48708987639288615	[169]	[279]	5	hSpCas9	negative selection	10130619
47224719	47224742	X	-	28162770	P31FUJ	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	0.43599188711024794	[38]	[61]	5	hSpCas9	negative selection	10130620
47223648	47223671	X	+	28162770	P31FUJ	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	-0.18261644724616177	[112]	[116]	-2	hSpCas9	negative selection	10130621
47224998	47225021	X	-	28162770	P31FUJ	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	1.0955953858025413	[177]	[446]	9	hSpCas9	negative selection	10130622
47225053	47225076	X	+	28162770	P31FUJ	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	-0.10727132233051972	[329]	[359]	-1	hSpCas9	negative selection	10130623
47226317	47226340	X	-	28162770	P31FUJ	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	0.8775040575023988	[257]	[556]	8	hSpCas9	negative selection	10130624
47226868	47226891	X	-	28162770	P31FUJ	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	0.9488046020755689	[573]	[1301]	9	hSpCas9	negative selection	10130625
47227173	47227196	X	+	28162770	P31FUJ	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	0.5653341876138469	[156]	[272]	6	hSpCas9	negative selection	10130626
47223588	47223611	X	+	28162770	P31FUJ	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	0.49302283214662723	[623]	[1031]	5	hSpCas9	negative selection	10130627
47224695	47224718	X	-	28162770	P31FUJ	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.7999019606583273	[566]	[1159]	8	hSpCas9	negative selection	10130628
47228589	47228612	X	+	28162770	TF1	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	NaN	[NaN]	[263]	1	hSpCas9	negative selection	10299985
47224719	47224742	X	-	28162770	TF1	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	NaN	[NaN]	[154]	1	hSpCas9	negative selection	10299986
47223648	47223671	X	+	28162770	TF1	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	NaN	[NaN]	[66]	1	hSpCas9	negative selection	10299987
47224998	47225021	X	-	28162770	TF1	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	NaN	[NaN]	[171]	1	hSpCas9	negative selection	10299988
47225053	47225076	X	+	28162770	TF1	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	NaN	[NaN]	[315]	1	hSpCas9	negative selection	10299989
47226317	47226340	X	-	28162770	TF1	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	NaN	[NaN]	[321]	1	hSpCas9	negative selection	10299990
47226868	47226891	X	-	28162770	TF1	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	NaN	[NaN]	[547]	1	hSpCas9	negative selection	10299991
47227173	47227196	X	+	28162770	TF1	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	NaN	[NaN]	[139]	1	hSpCas9	negative selection	10299992
47223588	47223611	X	+	28162770	TF1	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	NaN	[NaN]	[329]	1	hSpCas9	negative selection	10299993
47224695	47224718	X	-	28162770	TF1	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	NaN	[NaN]	[538]	1	hSpCas9	negative selection	10299994
47228589	47228612	X	+	28162770	SKM1	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	-0.2801079191927352	[67]	[98]	-2	hSpCas9	negative selection	10469351
47224719	47224742	X	-	28162770	SKM1	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	-1.0146467759644016	[15]	[13]	-6	hSpCas9	negative selection	10469352
47223648	47223671	X	+	28162770	SKM1	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	-0.3195013574928224	[35]	[50]	-3	hSpCas9	negative selection	10469353
47224998	47225021	X	-	28162770	SKM1	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	1.2953552526161534	[58]	[255]	9	hSpCas9	negative selection	10469354
47225053	47225076	X	+	28162770	SKM1	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	-0.4575902718131298	[86]	[111]	-4	hSpCas9	negative selection	10469355
47226317	47226340	X	-	28162770	SKM1	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	0.16685774437279394	[64]	[128]	1	hSpCas9	negative selection	10469356
47226868	47226891	X	-	28162770	SKM1	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	-0.3872009439217319	[144]	[195]	-3	hSpCas9	negative selection	10469357
47227173	47227196	X	+	28162770	SKM1	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	0.8672974625138862	[39]	[128]	7	hSpCas9	negative selection	10469358
47223588	47223611	X	+	28162770	SKM1	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	0.2943224199452261	[130]	[283]	3	hSpCas9	negative selection	10469359
47224695	47224718	X	-	28162770	SKM1	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.39708936022419117	[124]	[290]	4	hSpCas9	negative selection	10469360
47228589	47228612	X	+	28162770	SKM1	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	-0.2801079191927352	[67]	[98]	-2	hSpCas9	negative selection	10638717
47224719	47224742	X	-	28162770	SKM1	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	-1.0146467759644016	[15]	[13]	-6	hSpCas9	negative selection	10638718
47223648	47223671	X	+	28162770	SKM1	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	-0.3195013574928224	[35]	[50]	-3	hSpCas9	negative selection	10638719
47224998	47225021	X	-	28162770	SKM1	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	1.2953552526161534	[58]	[255]	9	hSpCas9	negative selection	10638720
47225053	47225076	X	+	28162770	SKM1	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	-0.4575902718131298	[86]	[111]	-4	hSpCas9	negative selection	10638721
47226317	47226340	X	-	28162770	SKM1	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	0.16685774437279394	[64]	[128]	1	hSpCas9	negative selection	10638722
47226868	47226891	X	-	28162770	SKM1	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	-0.3872009439217319	[144]	[195]	-3	hSpCas9	negative selection	10638723
47227173	47227196	X	+	28162770	SKM1	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	0.8672974625138862	[39]	[128]	7	hSpCas9	negative selection	10638724
47223588	47223611	X	+	28162770	SKM1	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	0.2943224199452261	[130]	[283]	3	hSpCas9	negative selection	10638725
47224695	47224718	X	-	28162770	SKM1	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.39708936022419117	[124]	[290]	4	hSpCas9	negative selection	10638726
47228589	47228612	X	+	28162770	PL21	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	-0.9356371645411465	[166]	[37]	-6	hSpCas9	negative selection	10808083
47224719	47224742	X	-	28162770	PL21	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	-0.9373639092606147	[43]	[9]	-6	hSpCas9	negative selection	10808084
47223648	47223671	X	+	28162770	PL21	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	0.3334061453527841	[92]	[50]	3	hSpCas9	negative selection	10808085
47224998	47225021	X	-	28162770	PL21	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	-0.7571559345564416	[232]	[59]	-5	hSpCas9	negative selection	10808086
47225053	47225076	X	+	28162770	PL21	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	0.6055910649389659	[301]	[199]	5	hSpCas9	negative selection	10808087
47226317	47226340	X	-	28162770	PL21	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	-0.16790040525235428	[301]	[116]	-1	hSpCas9	negative selection	10808088
47226868	47226891	X	-	28162770	PL21	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	-0.225390258607166	[367]	[136]	-2	hSpCas9	negative selection	10808089
47227173	47227196	X	+	28162770	PL21	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	-0.3417541643399502	[98]	[33]	-2	hSpCas9	negative selection	10808090
47223588	47223611	X	+	28162770	PL21	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	0.09448782692545743	[438]	[203]	0	hSpCas9	negative selection	10808091
47224695	47224718	X	-	28162770	PL21	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.4464506627319875	[375]	[222]	4	hSpCas9	negative selection	10808092
47228589	47228612	X	+	28162770	P31FUJ	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	0.48708987639288615	[169]	[279]	5	hSpCas9	negative selection	10977449
47224719	47224742	X	-	28162770	P31FUJ	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	0.43599188711024794	[38]	[61]	5	hSpCas9	negative selection	10977450
47223648	47223671	X	+	28162770	P31FUJ	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	-0.18261644724616177	[112]	[116]	-2	hSpCas9	negative selection	10977451
47224998	47225021	X	-	28162770	P31FUJ	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	1.0955953858025413	[177]	[446]	9	hSpCas9	negative selection	10977452
47225053	47225076	X	+	28162770	P31FUJ	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	-0.10727132233051972	[329]	[359]	-1	hSpCas9	negative selection	10977453
47226317	47226340	X	-	28162770	P31FUJ	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	0.8775040575023988	[257]	[556]	8	hSpCas9	negative selection	10977454
47226868	47226891	X	-	28162770	P31FUJ	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	0.9488046020755689	[573]	[1301]	9	hSpCas9	negative selection	10977455
47227173	47227196	X	+	28162770	P31FUJ	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	0.5653341876138469	[156]	[272]	6	hSpCas9	negative selection	10977456
47223588	47223611	X	+	28162770	P31FUJ	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	0.49302283214662723	[623]	[1031]	5	hSpCas9	negative selection	10977457
47224695	47224718	X	-	28162770	P31FUJ	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.7999019606583273	[566]	[1159]	8	hSpCas9	negative selection	10977458
47228589	47228612	X	+	28162770	OCIAML5	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	0.8026049016685635	[100]	[317]	7	hSpCas9	negative selection	11146815
47224719	47224742	X	-	28162770	OCIAML5	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	0.6438909237984143	[38]	[109]	5	hSpCas9	negative selection	11146816
47223648	47223671	X	+	28162770	OCIAML5	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	0.479139337611376	[61]	[155]	4	hSpCas9	negative selection	11146817
47224998	47225021	X	-	28162770	OCIAML5	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	0.4138274891090375	[125]	[302]	3	hSpCas9	negative selection	11146818
47225053	47225076	X	+	28162770	OCIAML5	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	0.34836051897565956	[207]	[477]	3	hSpCas9	negative selection	11146819
47226317	47226340	X	-	28162770	OCIAML5	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	1.147933429136003	[80]	[323]	8	hSpCas9	negative selection	11146820
47226868	47226891	X	-	28162770	OCIAML5	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	0.8384141209397209	[245]	[793]	7	hSpCas9	negative selection	11146821
47227173	47227196	X	+	28162770	OCIAML5	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	1.0121195737902833	[63]	[232]	8	hSpCas9	negative selection	11146822
47223588	47223611	X	+	28162770	OCIAML5	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	0.3775393407050256	[341]	[801]	3	hSpCas9	negative selection	11146823
47224695	47224718	X	-	28162770	OCIAML5	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.5206104266912015	[323]	[838]	4	hSpCas9	negative selection	11146824
47228589	47228612	X	+	28162770	EOL1	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	0.7444883929945093	[374]	[330]	6	hSpCas9	negative selection	11316181
47224719	47224742	X	-	28162770	EOL1	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	0.13928662036354722	[80]	[46]	1	hSpCas9	negative selection	11316182
47223648	47223671	X	+	28162770	EOL1	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	0.40814955733244973	[225]	[157]	4	hSpCas9	negative selection	11316183
47224998	47225021	X	-	28162770	EOL1	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	0.8480062166975414	[328]	[311]	7	hSpCas9	negative selection	11316184
47225053	47225076	X	+	28162770	EOL1	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	1.0765508650155842	[575]	[639]	8	hSpCas9	negative selection	11316185
47226317	47226340	X	-	28162770	EOL1	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	0.09799928427961979	[453]	[255]	0	hSpCas9	negative selection	11316186
47226868	47226891	X	-	28162770	EOL1	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	-0.05246058580323609	[497]	[252]	0	hSpCas9	negative selection	11316187
47227173	47227196	X	+	28162770	EOL1	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	0.6026196766831723	[119]	[95]	5	hSpCas9	negative selection	11316188
47223588	47223611	X	+	28162770	EOL1	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	0.7246462373565024	[540]	[470]	6	hSpCas9	negative selection	11316189
47224695	47224718	X	-	28162770	EOL1	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.32911193961986995	[552]	[365]	3	hSpCas9	negative selection	11316190
47228589	47228612	X	+	28162770	MOLM13	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	1.0374766563788187	[282]	[419]	7	hSpCas9	negative selection	11485547
47224719	47224742	X	-	28162770	MOLM13	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	1.1488209407964571	[62]	[100]	8	hSpCas9	negative selection	11485548
47223648	47223671	X	+	28162770	MOLM13	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	0.11558763761369772	[119]	[93]	0	hSpCas9	negative selection	11485549
47224998	47225021	X	-	28162770	MOLM13	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	0.02465499043508293	[309]	[227]	0	hSpCas9	negative selection	11485550
47225053	47225076	X	+	28162770	MOLM13	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	0.6270028641528187	[505]	[564]	5	hSpCas9	negative selection	11485551
47226317	47226340	X	-	28162770	MOLM13	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	0.6923209481546252	[302]	[353]	5	hSpCas9	negative selection	11485552
47226868	47226891	X	-	28162770	MOLM13	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	0.22631948489938225	[466]	[394]	1	hSpCas9	negative selection	11485553
47227173	47227196	X	+	28162770	MOLM13	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	0.2095773859531881	[182]	[152]	1	hSpCas9	negative selection	11485554
47223588	47223611	X	+	28162770	MOLM13	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	0.4678893815445786	[585]	[585]	3	hSpCas9	negative selection	11485555
47224695	47224718	X	-	28162770	MOLM13	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.13199863361916897	[596]	[472]	0	hSpCas9	negative selection	11485556
47228589	47228612	X	+	28162770	HEL	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	1.19819733841143	[246]	[362]	9	hSpCas9	negative selection	11654913
47224719	47224742	X	-	28162770	HEL	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	1.1227317731199706	[37]	[52]	8	hSpCas9	negative selection	11654914
47223648	47223671	X	+	28162770	HEL	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	1.0737178751482221	[134]	[181]	8	hSpCas9	negative selection	11654915
47224998	47225021	X	-	28162770	HEL	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	0.392898352476418	[282]	[237]	3	hSpCas9	negative selection	11654916
47225053	47225076	X	+	28162770	HEL	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	-0.1041422310309319	[437]	[260]	-1	hSpCas9	negative selection	11654917
47226317	47226340	X	-	28162770	HEL	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	1.1577993194913572	[295]	[422]	8	hSpCas9	negative selection	11654918
47226868	47226891	X	-	28162770	HEL	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	0.7901908332142201	[380]	[421]	6	hSpCas9	negative selection	11654919
47227173	47227196	X	+	28162770	HEL	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	1.0016332532416672	[130]	[167]	8	hSpCas9	negative selection	11654920
47223588	47223611	X	+	28162770	HEL	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	0.030664485661959784	[563]	[368]	0	hSpCas9	negative selection	11654921
47224695	47224718	X	-	28162770	HEL	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.36340261383746286	[533]	[439]	3	hSpCas9	negative selection	11654922
47228589	47228612	X	+	28162770	MV411	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	0.7949253460852687	[194]	[284]	7	hSpCas9	negative selection	11824279
47224719	47224742	X	-	28162770	MV411	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	0.3425947838231156	[43]	[46]	3	hSpCas9	negative selection	11824280
47223648	47223671	X	+	28162770	MV411	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	0.6130870230994557	[103]	[133]	5	hSpCas9	negative selection	11824281
47224998	47225021	X	-	28162770	MV411	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	-0.15748992085122748	[236]	[178]	-1	hSpCas9	negative selection	11824282
47225053	47225076	X	+	28162770	MV411	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	0.9104025635052045	[275]	[436]	7	hSpCas9	negative selection	11824283
47226317	47226340	X	-	28162770	MV411	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	1.119357736868221	[205]	[376]	8	hSpCas9	negative selection	11824284
47226868	47226891	X	-	28162770	MV411	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	0.9221302121599437	[373]	[596]	8	hSpCas9	negative selection	11824285
47227173	47227196	X	+	28162770	MV411	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	0.5693656456701377	[131]	[164]	5	hSpCas9	negative selection	11824286
47223588	47223611	X	+	28162770	MV411	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	0.6467481769825016	[391]	[516]	6	hSpCas9	negative selection	11824287
47224695	47224718	X	-	28162770	MV411	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.9323724421887662	[366]	[589]	8	hSpCas9	negative selection	11824288
47228589	47228612	X	+	28162770	MONOMAC1	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	0.7977642462661272	[138]	[276]	7	hSpCas9	negative selection	11993645
47224719	47224742	X	-	28162770	MONOMAC1	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	0.888354644171091	[40]	[86]	7	hSpCas9	negative selection	11993646
47223648	47223671	X	+	28162770	MONOMAC1	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	0.0830710721331816	[83]	[101]	0	hSpCas9	negative selection	11993647
47224998	47225021	X	-	28162770	MONOMAC1	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	0.4387300243330938	[185]	[288]	4	hSpCas9	negative selection	11993648
47225053	47225076	X	+	28162770	MONOMAC1	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	0.2635975186594006	[217]	[299]	2	hSpCas9	negative selection	11993649
47226317	47226340	X	-	28162770	MONOMAC1	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	0.04593990643298673	[168]	[199]	0	hSpCas9	negative selection	11993650
47226868	47226891	X	-	28162770	MONOMAC1	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	0.7998903188908231	[234]	[468]	7	hSpCas9	negative selection	11993651
47227173	47227196	X	+	28162770	MONOMAC1	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	0.37486950083615606	[73]	[109]	4	hSpCas9	negative selection	11993652
47223588	47223611	X	+	28162770	MONOMAC1	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	-0.026537409997114292	[278]	[313]	0	hSpCas9	negative selection	11993653
47224695	47224718	X	-	28162770	MONOMAC1	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.3390160531806561	[239]	[347]	3	hSpCas9	negative selection	11993654
47228589	47228612	X	+	28162770	OCIAML2	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	0.2663357689240449	[44]	[299]	2	hSpCas9	negative selection	12163011
47224719	47224742	X	-	28162770	OCIAML2	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	-0.6930222465786091	[13]	[47]	-5	hSpCas9	negative selection	12163012
47223648	47223671	X	+	28162770	OCIAML2	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	0.6549010568416977	[10]	[95]	6	hSpCas9	negative selection	12163013
47224998	47225021	X	-	28162770	OCIAML2	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	1.5688985389444763	[35]	[591]	9	hSpCas9	negative selection	12163014
47225053	47225076	X	+	28162770	OCIAML2	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	-0.34023318798648616	[73]	[323]	-3	hSpCas9	negative selection	12163015
47226317	47226340	X	-	28162770	OCIAML2	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	0.30643117450184343	[54]	[376]	3	hSpCas9	negative selection	12163016
47226868	47226891	X	-	28162770	OCIAML2	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	0.8817211902189543	[60]	[622]	8	hSpCas9	negative selection	12163017
47227173	47227196	X	+	28162770	OCIAML2	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	0.1825041781205743	[30]	[194]	1	hSpCas9	negative selection	12163018
47223588	47223611	X	+	28162770	OCIAML2	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	0.6402919888321672	[60]	[526]	6	hSpCas9	negative selection	12163019
47224695	47224718	X	-	28162770	OCIAML2	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.7688361094532281	[80]	[764]	7	hSpCas9	negative selection	12163020
47228589	47228612	X	+	28162770	OCIAML3	viability	GGAGATTCAGCTACAAAAGGAGG	CDK16	ENSG00000102225	0.09592441999853563	[52]	[170]	0	hSpCas9	negative selection	12332377
47224719	47224742	X	-	28162770	OCIAML3	viability	GGCTGACACGACGGAGGCGGCGG	CDK16	ENSG00000102225	-0.04381055776368381	[13]	[40]	0	hSpCas9	negative selection	12332378
47223648	47223671	X	+	28162770	OCIAML3	viability	ATAGGCCTGGATGAGAGTGGTGG	CDK16	ENSG00000102225	1.6283847810122847	[26]	[251]	9	hSpCas9	negative selection	12332379
47224998	47225021	X	-	28162770	OCIAML3	viability	GCTTTTGCCTTTGTAGACGGTGG	CDK16	ENSG00000102225	1	[52]	[319]	8	hSpCas9	negative selection	12332380
47225053	47225076	X	+	28162770	OCIAML3	viability	GATCAGACTGGAACATGAAGAGG	CDK16	ENSG00000102225	0.9492277347872697	[75]	[442]	7	hSpCas9	negative selection	12332381
47226317	47226340	X	-	28162770	OCIAML3	viability	GGTGTAGCACCTTCTGCCGGTGG	CDK16	ENSG00000102225	0.5434958834257717	[49]	[219]	5	hSpCas9	negative selection	12332382
47226868	47226891	X	-	28162770	OCIAML3	viability	GTGTAGCTGTTCCTCCACCGTGG	CDK16	ENSG00000102225	0.24110797493405434	[124]	[445]	2	hSpCas9	negative selection	12332383
47227173	47227196	X	+	28162770	OCIAML3	viability	TGTGGCAGACTTGATAGCGACGG	CDK16	ENSG00000102225	-0.9194079271183304	[51]	[82]	-6	hSpCas9	negative selection	12332384
47223588	47223611	X	+	28162770	OCIAML3	viability	CTGTCAATGACACTCCGAGGTGG	CDK16	ENSG00000102225	0.054421279240385534	[125]	[394]	0	hSpCas9	negative selection	12332385
47224695	47224718	X	-	28162770	OCIAML3	viability	TGAGGGGCTTGTCAAAGATGGGG	CDK16	ENSG00000102225	0.03859534604142767	[138]	[430]	0	hSpCas9	negative selection	12332386