Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:8814
• Symbol:CDKL1
• Description:cyclin dependent kinase like 1

DataSource: http://genomecrispr.dkfz.de/#!/results/CDKL1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
50359093	50359116	14	-	26472758	Jiyoye	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	0.2518971560279625	[97]	[87]	2	hSpCas9	negative selection	28921
50341164	50341187	14	-	26472758	Jiyoye	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	-1.114361739073649	[88]	[30]	-6	hSpCas9	negative selection	28922
50359028	50359051	14	-	26472758	Jiyoye	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	-0.1223739988966761	[165]	[114]	-1	hSpCas9	negative selection	28923
50341123	50341146	14	+	26472758	Jiyoye	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.5410311282406641	[215]	[236]	4	hSpCas9	negative selection	28924
50341189	50341212	14	-	26472758	Jiyoye	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	0.9921378822270296	[37]	[56]	6	hSpCas9	negative selection	28925
50332264	50332287	14	+	26472758	Jiyoye	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	0.9263701120760093	[186]	[267]	6	hSpCas9	negative selection	28926
50395703	50395726	14	+	26472758	Jiyoye	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.1379887486904845	[46]	[38]	1	hSpCas9	negative selection	28927
50341062	50341085	14	-	26472758	Jiyoye	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	-0.4398726956555278	[303]	[168]	-3	hSpCas9	negative selection	28928
50341032	50341055	14	-	26472758	Jiyoye	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	0.0029215579402708247	[310]	[234]	0	hSpCas9	negative selection	28929
50395790	50395813	14	-	26472758	Jiyoye	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	0.2645709860630731	[84]	[76]	2	hSpCas9	negative selection	28930
50359093	50359116	14	-	26472758	KBM7	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	0.01119912962939923	[408,297]	[266,74]	0	hSpCas9	negative selection	220039
50341164	50341187	14	-	26472758	KBM7	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	1.0924204728605234	[194,237]	[336,115]	9	hSpCas9	negative selection	220040
50359028	50359051	14	-	26472758	KBM7	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	0.3909934038251519	[548,339]	[281,256]	4	hSpCas9	negative selection	220041
50341123	50341146	14	+	26472758	KBM7	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.3093967500450847	[1233,864]	[688,526]	3	hSpCas9	negative selection	220042
50341189	50341212	14	-	26472758	KBM7	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	-0.09258752438653661	[265,134]	[87,83]	-1	hSpCas9	negative selection	220043
50332264	50332287	14	+	26472758	KBM7	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	0.6920907658448506	[936,650]	[651,543]	7	hSpCas9	negative selection	220044
50395703	50395726	14	+	26472758	KBM7	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.022980573502961066	[506,238]	[183,151]	0	hSpCas9	negative selection	220045
50341062	50341085	14	-	26472758	KBM7	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	0.17857443141033902	[1093,1092]	[731,452]	1	hSpCas9	negative selection	220046
50341032	50341055	14	-	26472758	KBM7	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	0.5267305675511695	[1504,1147]	[681,1076]	6	hSpCas9	negative selection	220047
50395790	50395813	14	-	26472758	KBM7	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	0.007352161394271195	[477,312]	[271,104]	0	hSpCas9	negative selection	220048
50359093	50359116	14	-	26472758	Raji	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	0.29501053854937087	[287]	[81]	3	hSpCas9	negative selection	411157
50341164	50341187	14	-	26472758	Raji	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	-0.27508610144881385	[145]	[27]	-2	hSpCas9	negative selection	411158
50359028	50359051	14	-	26472758	Raji	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	0.2766646202504849	[248]	[69]	2	hSpCas9	negative selection	411159
50341123	50341146	14	+	26472758	Raji	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	1.0199206941232601	[322]	[151]	8	hSpCas9	negative selection	411160
50341189	50341212	14	-	26472758	Raji	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	2.285170654588882	[60]	[68]	9	hSpCas9	negative selection	411161
50332264	50332287	14	+	26472758	Raji	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	0.20516942697455431	[384]	[102]	2	hSpCas9	negative selection	411162
50395703	50395726	14	+	26472758	Raji	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.2941520469793262	[122]	[34]	2	hSpCas9	negative selection	411163
50341062	50341085	14	-	26472758	Raji	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	-0.5518175956394751	[637]	[100]	-4	hSpCas9	negative selection	411164
50341032	50341055	14	-	26472758	Raji	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	0.16636025484593508	[694]	[180]	1	hSpCas9	negative selection	411165
50395790	50395813	14	-	26472758	Raji	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	1.356903134732912	[142]	[84]	9	hSpCas9	negative selection	411166
50359093	50359116	14	-	26472758	K562	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	1.3832690961143768	[291]	[642]	9	hSpCas9	negative selection	602275
50341164	50341187	14	-	26472758	K562	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	1.0961387202641142	[214]	[387]	8	hSpCas9	negative selection	602276
50359028	50359051	14	-	26472758	K562	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	0.04579699888971567	[310]	[270]	0	hSpCas9	negative selection	602277
50341123	50341146	14	+	26472758	K562	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.2995233271069011	[487]	[506]	2	hSpCas9	negative selection	602278
50341189	50341212	14	-	26472758	K562	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	-0.46523952050402384	[156]	[95]	-3	hSpCas9	negative selection	602279
50332264	50332287	14	+	26472758	K562	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	0.49114740096929843	[696]	[826]	4	hSpCas9	negative selection	602280
50395703	50395726	14	+	26472758	K562	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.7429412124483719	[234]	[331]	6	hSpCas9	negative selection	602281
50341062	50341085	14	-	26472758	K562	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	0.5626391926528609	[1012]	[1262]	4	hSpCas9	negative selection	602282
50341032	50341055	14	-	26472758	K562	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	0.6149043769894282	[928]	[1200]	5	hSpCas9	negative selection	602283
50395790	50395813	14	-	26472758	K562	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	1.454678593851696	[289]	[670]	9	hSpCas9	negative selection	602284
50341121	50341144	14	+	26627737	DLD1	viability	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	0.010473346593998956	[593]	[248,120,187]	0	hSpCas9	negative selection	788655
50341124	50341147	14	+	26627737	DLD1	viability	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-0.1853879230964911	[428]	[183,96,77]	-2	hSpCas9	negative selection	788656
50359101	50359124	14	+	26627737	DLD1	viability	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	0.8108220714256098	[173]	[57,186,51]	7	hSpCas9	negative selection	788657
50359102	50359125	14	-	26627737	DLD1	viability	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-2.5469031740492096	[85]	[2,6,3]	-9	hSpCas9	negative selection	788658
50395703	50395726	14	+	26627737	DLD1	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.602520738174738	[357]	[71,287,156]	6	hSpCas9	negative selection	788659
50395704	50395727	14	+	26627737	DLD1	viability	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.454020669346494	[214]	[133,40,97]	4	hSpCas9	negative selection	788660
50341121	50341144	14	+	26627737	GBM cells	viability after 5 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-0.23858964886424938	[417]	[226,152]	-4	hSpCas9	negative selection	870970
50341124	50341147	14	+	26627737	GBM cells	viability after 5 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-0.17508670655809122	[159]	[79,71]	-3	hSpCas9	negative selection	870971
50359101	50359124	14	+	26627737	GBM cells	viability after 5 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-0.38648834397656273	[155]	[51,75]	-6	hSpCas9	negative selection	870972
50359102	50359125	14	-	26627737	GBM cells	viability after 5 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-0.8869613197614672	[149]	[63,22]	-8	hSpCas9	negative selection	870973
50395703	50395726	14	+	26627737	GBM cells	viability after 5 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.2857648932466536	[257]	[97,128]	-4	hSpCas9	negative selection	870974
50395704	50395727	14	+	26627737	GBM cells	viability after 5 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.18094924264953527	[175]	[90,122]	3	hSpCas9	negative selection	870975
50341121	50341144	14	+	26627737	GBM cells	viability after 13 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-0.08136211808378191	[417]	[247,186]	-1	hSpCas9	negative selection	953285
50341124	50341147	14	+	26627737	GBM cells	viability after 13 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-0.25334655278240525	[159]	[79,66]	-3	hSpCas9	negative selection	953286
50359101	50359124	14	+	26627737	GBM cells	viability after 13 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-0.23898367949827248	[155]	[63,77]	-3	hSpCas9	negative selection	953287
50359102	50359125	14	-	26627737	GBM cells	viability after 13 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-1.2415773584558187	[149]	[45,24]	-8	hSpCas9	negative selection	953288
50395703	50395726	14	+	26627737	GBM cells	viability after 13 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.12399498529102418	[257]	[144,114]	-1	hSpCas9	negative selection	953289
50395704	50395727	14	+	26627737	GBM cells	viability after 13 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.017544933402189322	[175]	[110,84]	0	hSpCas9	negative selection	953290
50341121	50341144	14	+	26627737	GBM cells	viability after 21 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-0.6468851265332133	[417]	[155,134]	-5	hSpCas9	negative selection	1035600
50341124	50341147	14	+	26627737	GBM cells	viability after 21 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-1.497877630664828	[159]	[35,25]	-8	hSpCas9	negative selection	1035601
50359101	50359124	14	+	26627737	GBM cells	viability after 21 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-0.10728461450911964	[155]	[97,60]	-1	hSpCas9	negative selection	1035602
50359102	50359125	14	-	26627737	GBM cells	viability after 21 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-0.9639215406448975	[149]	[46,36]	-7	hSpCas9	negative selection	1035603
50395703	50395726	14	+	26627737	GBM cells	viability after 21 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.7850220429405759	[257]	[84,77]	-6	hSpCas9	negative selection	1035604
50395704	50395727	14	+	26627737	GBM cells	viability after 21 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.9408746509554939	[175]	[193,173]	8	hSpCas9	negative selection	1035605
50341121	50341144	14	+	26627737	RPE1	viability after 9 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-0.2720103861918971	[1265]	[353,294]	-2	hSpCas9	negative selection	1117915
50341124	50341147	14	+	26627737	RPE1	viability after 9 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-0.18842418953751505	[467]	[104,158]	-1	hSpCas9	negative selection	1117916
50359101	50359124	14	+	26627737	RPE1	viability after 9 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	0.45194027372452084	[510]	[227,206]	3	hSpCas9	negative selection	1117917
50359102	50359125	14	-	26627737	RPE1	viability after 9 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-3.4542349661357568	[356]	[14,3]	-9	hSpCas9	negative selection	1117918
50395703	50395726	14	+	26627737	RPE1	viability after 9 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.26496903985253717	[828]	[272,361]	2	hSpCas9	negative selection	1117919
50395704	50395727	14	+	26627737	RPE1	viability after 9 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.3472996236462599	[469]	[164,51]	-2	hSpCas9	negative selection	1117920
50341121	50341144	14	+	26627737	RPE1	viability after 12 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-0.13090355393277864	[1265]	[382,233]	-1	hSpCas9	negative selection	1200230
50341124	50341147	14	+	26627737	RPE1	viability after 12 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	0.007599345379473599	[467]	[122,129]	0	hSpCas9	negative selection	1200231
50359101	50359124	14	+	26627737	RPE1	viability after 12 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	0.21569832050710003	[510]	[190,125]	1	hSpCas9	negative selection	1200232
50359102	50359125	14	-	26627737	RPE1	viability after 12 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-2.0690956795262037	[356]	[17,27]	-8	hSpCas9	negative selection	1200233
50395703	50395726	14	+	26627737	RPE1	viability after 12 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.3196830427470059	[828]	[159,197]	-2	hSpCas9	negative selection	1200234
50395704	50395727	14	+	26627737	RPE1	viability after 12 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.13289013761451818	[469]	[102,175]	0	hSpCas9	negative selection	1200235
50341121	50341144	14	+	26627737	RPE1	viability after 15 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	0.2620951076586865	[1265]	[599,264]	1	hSpCas9	negative selection	1282545
50341124	50341147	14	+	26627737	RPE1	viability after 15 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	0.3041116874589351	[467]	[137,187]	2	hSpCas9	negative selection	1282546
50359101	50359124	14	+	26627737	RPE1	viability after 15 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	0.24503457098325582	[510]	[181,160]	1	hSpCas9	negative selection	1282547
50359102	50359125	14	-	26627737	RPE1	viability after 15 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-0.9645759693883607	[356]	[93,10]	-6	hSpCas9	negative selection	1282548
50395703	50395726	14	+	26627737	RPE1	viability after 15 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.03759392911754525	[828]	[313,169]	0	hSpCas9	negative selection	1282549
50395704	50395727	14	+	26627737	RPE1	viability after 15 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-1.253077999696055	[469]	[39,70]	-7	hSpCas9	negative selection	1282550
50341121	50341144	14	+	26627737	RPE1	viability after 18 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	0.04210551281505204	[1265]	[417,280]	0	hSpCas9	negative selection	1364860
50341124	50341147	14	+	26627737	RPE1	viability after 18 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	0.20396740141294578	[467]	[173,114]	1	hSpCas9	negative selection	1364861
50359101	50359124	14	+	26627737	RPE1	viability after 18 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	0.5819734390937786	[510]	[247,161]	3	hSpCas9	negative selection	1364862
50359102	50359125	14	-	26627737	RPE1	viability after 18 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-3.4095900342894296	[356]	[10,6]	-9	hSpCas9	negative selection	1364863
50395703	50395726	14	+	26627737	RPE1	viability after 18 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.05320713114996128	[828]	[291,133]	0	hSpCas9	negative selection	1364864
50395704	50395727	14	+	26627737	RPE1	viability after 18 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.378361735106702	[469]	[128,63]	-2	hSpCas9	negative selection	1364865
50341121	50341144	14	+	26627737	HeLa	viability after 8 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	1.520138156765157	[202]	[268,292,204]	9	hSpCas9	negative selection	1447175
50341124	50341147	14	+	26627737	HeLa	viability after 8 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-0.28819998049966555	[302]	[73,127,113]	-3	hSpCas9	negative selection	1447176
50359101	50359124	14	+	26627737	HeLa	viability after 8 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	0.3251884198581692	[227]	[149,36,186]	3	hSpCas9	negative selection	1447177
50359102	50359125	14	-	26627737	HeLa	viability after 8 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	0.9078012013837228	[136]	[131,140,69]	7	hSpCas9	negative selection	1447178
50395703	50395726	14	+	26627737	HeLa	viability after 8 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.05112559729642813	[280]	[173,142,53]	0	hSpCas9	negative selection	1447179
50395704	50395727	14	+	26627737	HeLa	viability after 8 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.4259707340941131	[156]	[89,167,21]	4	hSpCas9	negative selection	1447180
50341121	50341144	14	+	26627737	HeLa	viability after 12 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	1.6101623261953977	[202]	[330,260,177]	9	hSpCas9	negative selection	1529490
50341124	50341147	14	+	26627737	HeLa	viability after 12 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-1.1126088807245091	[302]	[53,91,23]	-7	hSpCas9	negative selection	1529491
50359101	50359124	14	+	26627737	HeLa	viability after 12 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-0.5799506758862036	[227]	[87,51,50]	-5	hSpCas9	negative selection	1529492
50359102	50359125	14	-	26627737	HeLa	viability after 12 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-0.9014192677468227	[136]	[5,22,61]	-7	hSpCas9	negative selection	1529493
50395703	50395726	14	+	26627737	HeLa	viability after 12 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.03506113592677451	[280]	[116,117,121]	0	hSpCas9	negative selection	1529494
50395704	50395727	14	+	26627737	HeLa	viability after 12 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	1.0739026526541553	[156]	[196,131,82]	7	hSpCas9	negative selection	1529495
50341121	50341144	14	+	26627737	HeLa	viability after 15 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	1.6841042310279941	[202]	[273,263,257]	9	hSpCas9	negative selection	1611805
50341124	50341147	14	+	26627737	HeLa	viability after 15 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	0.09577575376401659	[302]	[140,29,231]	0	hSpCas9	negative selection	1611806
50359101	50359124	14	+	26627737	HeLa	viability after 15 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-0.2467345495235007	[227]	[129,25,77]	-2	hSpCas9	negative selection	1611807
50359102	50359125	14	-	26627737	HeLa	viability after 15 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-0.06814638243574112	[136]	[20,85,52]	0	hSpCas9	negative selection	1611808
50395703	50395726	14	+	26627737	HeLa	viability after 15 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.06762517245863059	[280]	[70,86,174]	0	hSpCas9	negative selection	1611809
50395704	50395727	14	+	26627737	HeLa	viability after 15 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.8688275300885568	[156]	[98,78,176]	6	hSpCas9	negative selection	1611810
50341121	50341144	14	+	26627737	HeLa	viability after 18 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	1.7048338546673207	[202]	[194,213,257]	9	hSpCas9	negative selection	1694120
50341124	50341147	14	+	26627737	HeLa	viability after 18 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	0.11656133500485977	[302]	[98,23,231]	1	hSpCas9	negative selection	1694121
50359101	50359124	14	+	26627737	HeLa	viability after 18 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-0.2875900428565399	[227]	[84,18,77]	-2	hSpCas9	negative selection	1694122
50359102	50359125	14	-	26627737	HeLa	viability after 18 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-0.0745524222806766	[136]	[12,71,52]	0	hSpCas9	negative selection	1694123
50395703	50395726	14	+	26627737	HeLa	viability after 18 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.05321985551883651	[280]	[48,72,174]	0	hSpCas9	negative selection	1694124
50395704	50395727	14	+	26627737	HeLa	viability after 18 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.904246839716544	[156]	[69,67,176]	6	hSpCas9	negative selection	1694125
50341121	50341144	14	+	26627737	HCT116	viability after 6 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-1.3968155615904745	[766]	[97,16]	-7	hSpCas9	negative selection	1776435
50341124	50341147	14	+	26627737	HCT116	viability after 6 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	0.958443614808278	[224]	[60,72]	5	hSpCas9	negative selection	1776436
50359101	50359124	14	+	26627737	HCT116	viability after 6 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-2.075219245495592	[450]	[1,24]	-8	hSpCas9	negative selection	1776437
50359102	50359125	14	-	26627737	HCT116	viability after 6 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	0.03810863807949394	[272]	[45,42]	0	hSpCas9	negative selection	1776438
50395703	50395726	14	+	26627737	HCT116	viability after 6 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-1.9144060744220395	[463]	[48,2]	-8	hSpCas9	negative selection	1776439
50395704	50395727	14	+	26627737	HCT116	viability after 6 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.20122412216006935	[324]	[66,31]	-1	hSpCas9	negative selection	1776440
50341121	50341144	14	+	26627737	HCT116	viability after 8 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-0.5002822364119887	[454]	[137,211,180]	-5	hSpCas9	negative selection	1858750
50341124	50341147	14	+	26627737	HCT116	viability after 8 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	0.4516864484435621	[162]	[141,115,110]	5	hSpCas9	negative selection	1858751
50359101	50359124	14	+	26627737	HCT116	viability after 8 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-0.8581029350564083	[280]	[111,80,63]	-8	hSpCas9	negative selection	1858752
50359102	50359125	14	-	26627737	HCT116	viability after 8 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	0.2555372427824585	[79]	[48,71,36]	3	hSpCas9	negative selection	1858753
50395703	50395726	14	+	26627737	HCT116	viability after 8 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.6381320805790123	[312]	[125,117,88]	-7	hSpCas9	negative selection	1858754
50395704	50395727	14	+	26627737	HCT116	viability after 8 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.6298608306396437	[266]	[113,111,59]	-6	hSpCas9	negative selection	1858755
50341121	50341144	14	+	26627737	HCT116	viability after 9 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-1.3227617029948886	[766]	[125,46]	-7	hSpCas9	negative selection	1941065
50341124	50341147	14	+	26627737	HCT116	viability after 9 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	2.107263974743483	[224]	[283,238]	9	hSpCas9	negative selection	1941066
50359101	50359124	14	+	26627737	HCT116	viability after 9 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-0.2409708157705005	[450]	[140,70]	-2	hSpCas9	negative selection	1941067
50359102	50359125	14	-	26627737	HCT116	viability after 9 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	1.6094560201136545	[272]	[141,285]	8	hSpCas9	negative selection	1941068
50395703	50395726	14	+	26627737	HCT116	viability after 9 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.019328889405754113	[463]	[143,110]	0	hSpCas9	negative selection	1941069
50395704	50395727	14	+	26627737	HCT116	viability after 9 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.2777088848243553	[324]	[127,26]	-2	hSpCas9	negative selection	1941070
50341121	50341144	14	+	26627737	HCT116	viability after 12 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-0.5090227141710044	[454]	[122,207,177]	-5	hSpCas9	negative selection	2023380
50341124	50341147	14	+	26627737	HCT116	viability after 12 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	0.5172423893166791	[162]	[139,28,194]	5	hSpCas9	negative selection	2023381
50359101	50359124	14	+	26627737	HCT116	viability after 12 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-0.5814354692847082	[280]	[86,135,74]	-6	hSpCas9	negative selection	2023382
50359102	50359125	14	-	26627737	HCT116	viability after 12 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	0.6420041222555053	[79]	[51,64,80]	6	hSpCas9	negative selection	2023383
50395703	50395726	14	+	26627737	HCT116	viability after 12 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.016192361185880813	[312]	[82,68,351]	0	hSpCas9	negative selection	2023384
50395704	50395727	14	+	26627737	HCT116	viability after 12 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.5096146275388775	[266]	[84,103,107]	-5	hSpCas9	negative selection	2023385
50341121	50341144	14	+	26627737	HCT116	viability after 15 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-0.5532611427892257	[454]	[191,255,88]	-5	hSpCas9	negative selection	2105695
50341124	50341147	14	+	26627737	HCT116	viability after 15 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-0.4244777471376313	[162]	[100,37,73]	-4	hSpCas9	negative selection	2105696
50359101	50359124	14	+	26627737	HCT116	viability after 15 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-0.29052912323665403	[280]	[96,114,178]	-3	hSpCas9	negative selection	2105697
50359102	50359125	14	-	26627737	HCT116	viability after 15 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	1.708174331638277	[79]	[162,144,143]	9	hSpCas9	negative selection	2105698
50395703	50395726	14	+	26627737	HCT116	viability after 15 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.5243525629440252	[312]	[113,84,173]	-5	hSpCas9	negative selection	2105699
50395704	50395727	14	+	26627737	HCT116	viability after 15 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.6448059253440749	[266]	[135,78,83]	-6	hSpCas9	negative selection	2105700
50341121	50341144	14	+	26627737	HCT116	viability after 18 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-0.3302929468790704	[454]	[166,219,132]	-3	hSpCas9	negative selection	2188010
50341124	50341147	14	+	26627737	HCT116	viability after 18 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	0.453526525345299	[162]	[115,127,76]	4	hSpCas9	negative selection	2188011
50359101	50359124	14	+	26627737	HCT116	viability after 18 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-0.6234049947460926	[280]	[93,81,88]	-5	hSpCas9	negative selection	2188012
50359102	50359125	14	-	26627737	HCT116	viability after 18 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	0.5004137057950262	[79]	[35,54,73]	4	hSpCas9	negative selection	2188013
50395703	50395726	14	+	26627737	HCT116	viability after 18 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-1.015993734572819	[312]	[40,49,137]	-7	hSpCas9	negative selection	2188014
50395704	50395727	14	+	26627737	HCT116	viability after 18 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.8005300483266902	[266]	[96,58,66]	-6	hSpCas9	negative selection	2188015
50359098	50359121	14	+	24336569	HL60	viability	GTTTCCTCCTGAAGACTTCCAGG	CDKL1	ENSG00000100490	0.5339707523165301	[405]	[1243]	5	hSpCas9	negative selection	2256779
50359105	50359128	14	-	24336569	HL60	viability	TTAACCTCCTGGAAGTCTTCAGG	CDKL1	ENSG00000100490	-0.26082595903771044	[277]	[490]	-2	hSpCas9	negative selection	2256780
50359110	50359133	14	+	24336569	HL60	viability	AGACTTCCAGGAGGTTAACAAGG	CDKL1	ENSG00000100490	0.4671210793924986	[829]	[2427]	4	hSpCas9	negative selection	2256781
50359115	50359138	14	+	24336569	HL60	viability	TCCAGGAGGTTAACAAGGTTGGG	CDKL1	ENSG00000100490	0.46838880705289754	[817]	[2394]	4	hSpCas9	negative selection	2256782
50395691	50395714	14	+	24336569	HL60	viability	AATCAATTACCTTGAGCATTCGG	CDKL1	ENSG00000100490	-0.3167276730398941	[637]	[1083]	-3	hSpCas9	negative selection	2256783
50395700	50395723	14	-	24336569	HL60	viability	TCGGGAAATCCGAATGCTCAAGG	CDKL1	ENSG00000100490	-0.5055386453731353	[1120]	[1670]	-4	hSpCas9	negative selection	2256784
50395755	50395778	14	+	24336569	HL60	viability	TGATTCCAGAAACTTCTTGATGG	CDKL1	ENSG00000100490	-0.3024043879314319	[330]	[567]	-3	hSpCas9	negative selection	2256785
50395760	50395783	14	-	24336569	HL60	viability	TGTGGCCATCAAGAAGTTTCTGG	CDKL1	ENSG00000100490	0.18119019848661666	[948]	[2276]	1	hSpCas9	negative selection	2256786
50395778	50395801	14	-	24336569	HL60	viability	CAGGGACACGGGTCAGATTGTGG	CDKL1	ENSG00000100490	0.03449680440776359	[1146]	[2485]	0	hSpCas9	negative selection	2256787
50395789	50395812	14	-	24336569	HL60	viability	AAATGTAGAAACAGGGACACGGG	CDKL1	ENSG00000100490	1.4129311902632316	[62]	[354]	8	hSpCas9	negative selection	2256788
50359098	50359121	14	+	24336569	KBM7	viability	GTTTCCTCCTGAAGACTTCCAGG	CDKL1	ENSG00000100490	0.43319679497809077	[248]	[916]	4	hSpCas9	negative selection	2323956
50359105	50359128	14	-	24336569	KBM7	viability	TTAACCTCCTGGAAGTCTTCAGG	CDKL1	ENSG00000100490	0.6703937252587084	[310]	[1349]	6	hSpCas9	negative selection	2323957
50359110	50359133	14	+	24336569	KBM7	viability	AGACTTCCAGGAGGTTAACAAGG	CDKL1	ENSG00000100490	0.6399867569511444	[822]	[3497]	6	hSpCas9	negative selection	2323958
50359115	50359138	14	+	24336569	KBM7	viability	TCCAGGAGGTTAACAAGGTTGGG	CDKL1	ENSG00000100490	-0.2330863880376185	[810]	[1881]	-2	hSpCas9	negative selection	2323959
50395691	50395714	14	+	24336569	KBM7	viability	AATCAATTACCTTGAGCATTCGG	CDKL1	ENSG00000100490	1.0954110336969576	[464]	[2709]	8	hSpCas9	negative selection	2323960
50395700	50395723	14	-	24336569	KBM7	viability	TCGGGAAATCCGAATGCTCAAGG	CDKL1	ENSG00000100490	0.3787338832126059	[539]	[1914]	3	hSpCas9	negative selection	2323961
50395755	50395778	14	+	24336569	KBM7	viability	TGATTCCAGAAACTTCTTGATGG	CDKL1	ENSG00000100490	0.798266505507651	[291]	[1384]	7	hSpCas9	negative selection	2323962
50395760	50395783	14	-	24336569	KBM7	viability	TGTGGCCATCAAGAAGTTTCTGG	CDKL1	ENSG00000100490	1.1802159444009117	[718]	[4443]	8	hSpCas9	negative selection	2323963
50395778	50395801	14	-	24336569	KBM7	viability	CAGGGACACGGGTCAGATTGTGG	CDKL1	ENSG00000100490	0.06104291430105491	[995]	[2833]	0	hSpCas9	negative selection	2323964
50395789	50395812	14	-	24336569	KBM7	viability	AAATGTAGAAACAGGGACACGGG	CDKL1	ENSG00000100490	-0.19123944328909692	[107]	[257]	-2	hSpCas9	negative selection	2323965
50333291	50333314	14	+	25494202	A375	resistance to PLX-4720 (puromycin)	ACAGGATGCAGTAAAGAAGCCGG	CDKL1	ENSG00000100490	4.925679733304566	[16,9]	[174,7]	9	dCas9-VP64	positive selection	2397758
50364314	50364337	14	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAAAAATTAGCTGGGCGTGGCGG	CDKL1	ENSG00000100490	-0.7800023955638035	[210,54]	[8,23]	-4	dCas9-VP64	positive selection	2414251
50405102	50405125	14	+	25494202	A375	resistance to PLX-4720 (puromycin)	TTTCACCGTGTTAGCTAGGATGG	CDKL1	ENSG00000100490	-0.43622771658323056	[174,104]	[36,6]	-2	dCas9-VP64	positive selection	2433031
50395996	50396019	14	-	25494202	A375	resistance to PLX-4720 (puromycin)	GAGACGGAGTTTCAGTATGTTGG	CDKL1	ENSG00000100490	0.62512894270579	[158,208]	[90,31]	2	dCas9-VP64	positive selection	2434840
50396059	50396082	14	+	25494202	A375	resistance to PLX-4720 (puromycin)	GCCCGTAGTCCCAGCAACTCAGG	CDKL1	ENSG00000100490	-0.09919808155600685	[59,249]	[4,60]	0	dCas9-VP64	positive selection	2434843
50385759	50385782	14	+	25494202	A375	resistance to PLX-4720 (puromycin)	GCGCCACTGCACTCCAACCTAGG	CDKL1	ENSG00000100490	2.1497742914119513	[2,11]	[5,8]	7	dCas9-VP64	positive selection	2439363
50364190	50364213	14	-	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCATGAGTCACCACGCCCAG	CDKL1	ENSG00000100490	3.599242638299855	[15,27]	[106,7]	9	dCas9-VP64	positive selection	2467144
50339523	50339546	14	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGAGAGGGAGGGAGGGAGGGGAG	CDKL1	ENSG00000100490	0.9305428154912776	[3,4]	[0,1]	4	dCas9-VP64	positive selection	2467722
50404239	50404262	14	-	25494202	A375	resistance to PLX-4720 (puromycin)	GAGAATCGCTTGAACCCTGGGGG	CDKL1	ENSG00000100490	-0.5583774166941213	[49,17]	[4,3]	-3	dCas9-VP64	positive selection	2470304
50333291	50333314	14	+	25494202	A375	resistance to PLX-4720 (zeocin)	ACAGGATGCAGTAAAGAAGCCGG	CDKL1	ENSG00000100490	0.38906795686834106	[19,135]	[18,44]	3	dCas9-VP64	positive selection	2493013
50364314	50364337	14	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAAAAATTAGCTGGGCGTGGCGG	CDKL1	ENSG00000100490	7.182660032259671	[52,50]	[5183,10]	9	dCas9-VP64	positive selection	2509506
50405102	50405125	14	+	25494202	A375	resistance to PLX-4720 (zeocin)	TTTCACCGTGTTAGCTAGGATGG	CDKL1	ENSG00000100490	1.4735482921306557	[116,143]	[227,15]	8	dCas9-VP64	positive selection	2528286
50395996	50396019	14	-	25494202	A375	resistance to PLX-4720 (zeocin)	GAGACGGAGTTTCAGTATGTTGG	CDKL1	ENSG00000100490	-0.9418353229864258	[206,370]	[57,39]	-8	dCas9-VP64	positive selection	2530095
50396059	50396082	14	+	25494202	A375	resistance to PLX-4720 (zeocin)	GCCCGTAGTCCCAGCAACTCAGG	CDKL1	ENSG00000100490	-1.1997805463634432	[197,263]	[25,37]	-9	dCas9-VP64	positive selection	2530098
50385759	50385782	14	+	25494202	A375	resistance to PLX-4720 (zeocin)	GCGCCACTGCACTCCAACCTAGG	CDKL1	ENSG00000100490	0.6658120072320489	[88,38]	[30,34]	5	dCas9-VP64	positive selection	2534618
50364190	50364213	14	-	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCATGAGTCACCACGCCCAG	CDKL1	ENSG00000100490	-1.0056755342139323	[143,43]	[19,9]	-8	dCas9-VP64	positive selection	2562399
50339523	50339546	14	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGAGAGGGAGGGAGGGAGGGGAG	CDKL1	ENSG00000100490	0.5788861668152605	[2,6]	[2,1]	4	dCas9-VP64	positive selection	2562977
50404239	50404262	14	-	25494202	A375	resistance to PLX-4720 (zeocin)	GAGAATCGCTTGAACCCTGGGGG	CDKL1	ENSG00000100490	-1.4985881155418108	[182,12]	[19,2]	-9	dCas9-VP64	positive selection	2565559
50395755	50395778	14	+	27013184	SW480	treatment with recombinant TRAIL	TGATTCCAGAAACTTCTTGATGG	CDKL1	ENSG00000100490	-1.6380884636336945	[141,204]	[14,35]	-6	hSpCas9	positive selection	2956130
50395806	50395829	14	+	27013184	SW480	treatment with recombinant TRAIL	ACATTTGAAAACAACTCCATAGG	CDKL1	ENSG00000100490	2.680916109281334	[45,121]	[147,329]	9	hSpCas9	positive selection	2956131
50395865	50395888	14	-	27013184	SW480	treatment with recombinant TRAIL	GAAGATTTATTCCTCTATGATGG	CDKL1	ENSG00000100490	-0.1421391881847962	[70,65]	[4,57]	0	hSpCas9	positive selection	2956132
50395700	50395723	14	-	27013184	SW480	treatment with recombinant TRAIL	TCGGGAAATCCGAATGCTCAAGG	CDKL1	ENSG00000100490	-0.43128045066637233	[463,512]	[134,184]	-2	hSpCas9	positive selection	2956133
50395718	50395741	14	-	27013184	SW480	treatment with recombinant TRAIL	CATAAAGAAAATTGCCCTTCGGG	CDKL1	ENSG00000100490	0.11564171121038269	[94,22]	[19,41]	0	hSpCas9	positive selection	2956134
50338929	50338952	14	-	27013184	SW480	treatment with recombinant TRAIL	ATATGGTGAGTTACCCATTTTGG	CDKL1	ENSG00000100490	-2.718078425638633	[603,548]	[25,54]	-8	hSpCas9	positive selection	2956135
50338946	50338969	14	-	27013184	SW480	treatment with recombinant TRAIL	AATTCCAGACCCTGAAGATATGG	CDKL1	ENSG00000100490	0.2091676421796147	[289,593]	[84,396]	1	hSpCas9	positive selection	2956136
50338975	50338998	14	-	27013184	SW480	treatment with recombinant TRAIL	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	3.269534342206076	[113,113]	[324,686]	9	hSpCas9	positive selection	2956137
50339013	50339036	14	-	27013184	SW480	treatment with recombinant TRAIL	CCAAAGGGGATCTCATTCCTAGG	CDKL1	ENSG00000100490	-0.986566326742476	[277,284]	[33,99]	-4	hSpCas9	positive selection	2956138
50339027	50339050	14	-	27013184	SW480	treatment with recombinant TRAIL	TTTTCTTTTCTTGTCCAAAGGGG	CDKL1	ENSG00000100490	1.7585668978488351	[82,82]	[36,240]	7	hSpCas9	positive selection	2956139
50395719	50395742	14	-	27013184	SW480	treatment with recombinant TRAIL	TCATAAAGAAAATTGCCCTTCGG	CDKL1	ENSG00000100490	1.5623171448039337	[143,161]	[129,284]	7	hSpCas9	positive selection	2956140
50395854	50395877	14	+	27013184	SW480	treatment with recombinant TRAIL	TTCATACTTCTCCATCATAGAGG	CDKL1	ENSG00000100490	1.3297661344289515	[196,284]	[283,218]	6	hSpCas9	positive selection	2956141
50395691	50395714	14	+	27013184	SW480	treatment with recombinant TRAIL	AATCAATTACCTTGAGCATTCGG	CDKL1	ENSG00000100490	1.7560994549456206	[674,840]	[952,1294]	7	hSpCas9	positive selection	2956142
50341123	50341146	14	+	27013184	SW480	treatment with recombinant TRAIL	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	-1.3055082488730756	[10,11]	[1,1]	-6	hSpCas9	positive selection	2956143
50395703	50395726	14	+	27013184	SW480	treatment with recombinant TRAIL	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-1.3574787827262293	[177,96]	[24,21]	-6	hSpCas9	positive selection	2956144
50341124	50341147	14	+	27013184	SW480	treatment with recombinant TRAIL	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-1.7514467807546898	[260,280]	[20,53]	-7	hSpCas9	positive selection	2956145
50395704	50395727	14	+	27013184	SW480	treatment with recombinant TRAIL	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.8045288779788407	[169,232]	[124,184]	4	hSpCas9	positive selection	2956146
50341125	50341148	14	+	27013184	SW480	treatment with recombinant TRAIL	TTGCCCAAACATCCACCGGGGGG	CDKL1	ENSG00000100490	-0.6608165883633079	[86,189]	[50,15]	-3	hSpCas9	positive selection	2956147
50395723	50395746	14	+	27013184	SW480	treatment with recombinant TRAIL	AGGGCAATTTTCTTTATGACAGG	CDKL1	ENSG00000100490	-1.3324378359757374	[357,588]	[92,59]	-6	hSpCas9	positive selection	2956148
50338936	50338959	14	+	27013184	SW480	treatment with recombinant TRAIL	GGGTAACTCACCATATCTTCAGG	CDKL1	ENSG00000100490	-0.4609231427958302	[188,201]	[37,93]	-2	hSpCas9	positive selection	2956149
50338937	50338960	14	+	27013184	SW480	treatment with recombinant TRAIL	GGTAACTCACCATATCTTCAGGG	CDKL1	ENSG00000100490	1.0689818903453978	[198,132]	[128,186]	5	hSpCas9	positive selection	2956150
50338942	50338965	14	+	27013184	SW480	treatment with recombinant TRAIL	CTCACCATATCTTCAGGGTCTGG	CDKL1	ENSG00000100490	-1.514294808113196	[193,204]	[1,69]	-6	hSpCas9	positive selection	2956151
50338988	50339011	14	+	27013184	SW480	treatment with recombinant TRAIL	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.055054829239510994	[368,447]	[147,196]	0	hSpCas9	positive selection	2956152
50338996	50339019	14	+	27013184	SW480	treatment with recombinant TRAIL	CTAAACACTTGCTGGTGCCTAGG	CDKL1	ENSG00000100490	-0.1075946671491117	[243,560]	[162,144]	0	hSpCas9	positive selection	2956153
50339013	50339036	14	+	27013184	SW480	treatment with recombinant TRAIL	CCTAGGAATGAGATCCCCTTTGG	CDKL1	ENSG00000100490	1.1465610248248876	[350,572]	[452,401]	5	hSpCas9	positive selection	2956154
50341042	50341065	14	-	27013184	SW480	treatment with recombinant TRAIL	TGGATCAGCTGTATCTGATTAGG	CDKL1	ENSG00000100490	-0.3068930485622354	[112,160]	[51,39]	-1	hSpCas9	positive selection	2956155
50341062	50341085	14	-	27013184	SW480	treatment with recombinant TRAIL	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	2.040065231588149	[1,95]	[93,58]	8	hSpCas9	positive selection	2956156
50341121	50341144	14	-	27013184	SW480	treatment with recombinant TRAIL	CCGGTGGATGTTTGGGCAATTGG	CDKL1	ENSG00000100490	1.2803236658107808	[278,250]	[224,355]	6	hSpCas9	positive selection	2956157
50395760	50395783	14	-	27013184	SW480	treatment with recombinant TRAIL	TGTGGCCATCAAGAAGTTTCTGG	CDKL1	ENSG00000100490	2.333062913656805	[617,650]	[1361,1396]	8	hSpCas9	positive selection	2956158
50395778	50395801	14	-	27013184	SW480	treatment with recombinant TRAIL	CAGGGACACGGGTCAGATTGTGG	CDKL1	ENSG00000100490	-0.4579507083631511	[7,45]	[2,14]	-2	hSpCas9	positive selection	2956159
50359027	50359050	14	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AGTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	0.11198154936173338	[2,2]	[3,1]	2	hSpCas9	positive selection	2978237
50341189	50341212	14	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	-0.1574254291046637	[4,3]	[3,2]	-2	hSpCas9	positive selection	2978238
50395705	50395728	14	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.16929367152676922	[3,3]	[2,4]	3	hSpCas9	positive selection	2978239
50395704	50395727	14	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.03127907652257697	[3,3]	[3,1]	0	hSpCas9	positive selection	2978240
50359027	50359050	14	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AGTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	0.16019802314557446	[2,2]	[2,1]	3	hSpCas9	positive selection	3046095
50341189	50341212	14	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	0.1563276200045852	[4,4]	[2,3]	2	hSpCas9	positive selection	3046096
50395705	50395728	14	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.15870794247596293	[3,3]	[3,2]	3	hSpCas9	positive selection	3046097
50395704	50395727	14	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.10237221125875773	[3,3]	[2,1]	-1	hSpCas9	positive selection	3046098
50359093	50359116		-	24336571	A375	resistance to PLX after 7 days	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	0.2756559274361571	[5,5]	[5,7]	7	hSpCas9	positive selection	3104656
50359044	50359067		-	24336571	A375	resistance to PLX after 7 days	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.1351640258406761	[13,11]	[10,11]	-4	hSpCas9	positive selection	3104657
50342149	50342172		-	24336571	A375	resistance to PLX after 7 days	GTGATTAAGCTTTGTGACTTTGG	CDKL1	ENSG00000100490	-0.04770247899500235	[21,22]	[22,18]	-1	hSpCas9	positive selection	3104658
50342179	50342202		+	24336571	A375	resistance to PLX after 7 days	TTCGTGATGAGGATATTTTCTGG	CDKL1	ENSG00000100490	-0.032536695616200095	[30,26]	[26,27]	-1	hSpCas9	positive selection	3104659
50359093	50359116		-	24336571	A375	resistance to PLX after 14 days	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	0.6189896208789836	[6,5]	[4,4]	5	hSpCas9	positive selection	3162449
50359044	50359067		-	24336571	A375	resistance to PLX after 14 days	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.6161065845612854	[14,11]	[3,3]	-7	hSpCas9	positive selection	3162450
50342149	50342172		-	24336571	A375	resistance to PLX after 14 days	GTGATTAAGCTTTGTGACTTTGG	CDKL1	ENSG00000100490	-0.4496011471602017	[34,29]	[10,10]	-5	hSpCas9	positive selection	3162451
50342179	50342202		+	24336571	A375	resistance to PLX after 14 days	TTCGTGATGAGGATATTTTCTGG	CDKL1	ENSG00000100490	-0.3875162608402607	[30,31]	[11,9]	-4	hSpCas9	positive selection	3162452
50359093	50359116		-	24336571	A375	viability after 7 days	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	-0.09505628528496235	[6]	[5,5]	-1	hSpCas9	negative selection	3220242
50359044	50359067		-	24336571	A375	viability after 7 days	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.16515287477658733	[14]	[13,11]	-2	hSpCas9	negative selection	3220243
50342149	50342172		-	24336571	A375	viability after 7 days	GTGATTAAGCTTTGTGACTTTGG	CDKL1	ENSG00000100490	0.36208358057512013	[17]	[21,22]	5	hSpCas9	negative selection	3220244
50342179	50342202		+	24336571	A375	viability after 7 days	TTCGTGATGAGGATATTTTCTGG	CDKL1	ENSG00000100490	0.5830579801014557	[19]	[30,26]	8	hSpCas9	negative selection	3220245
50359093	50359116		-	24336571	A375	viability after 14 days	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	0.1334710365811318	[6]	[6,5]	1	hSpCas9	negative selection	3278035
50359044	50359067		-	24336571	A375	viability after 14 days	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.07415629701115234	[14]	[14,11]	-1	hSpCas9	negative selection	3278036
50342149	50342172		-	24336571	A375	viability after 14 days	GTGATTAAGCTTTGTGACTTTGG	CDKL1	ENSG00000100490	0.9313193195731772	[17]	[34,29]	9	hSpCas9	negative selection	3278037
50342179	50342202		+	24336571	A375	viability after 14 days	TTCGTGATGAGGATATTTTCTGG	CDKL1	ENSG00000100490	0.7472218933040073	[19]	[30,31]	8	hSpCas9	negative selection	3278038
50359116	50359139	14	-	27383988	293T	resistance to West Nile virus (flavivirus)	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	-0.9171426121826148	[274,302]	[0,0]	-6	hSpCas9	positive selection	3342447
50345025	50345048	14	-	27383988	293T	resistance to West Nile virus (flavivirus)	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	-0.5134941995980367	[202,233]	[0,0]	-3	hSpCas9	positive selection	3342448
50338988	50339011	14	+	27383988	293T	resistance to West Nile virus (flavivirus)	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	0.334105550962826	[100,141]	[0,0]	1	hSpCas9	positive selection	3342449
50338975	50338998	14	-	27383988	293T	resistance to West Nile virus (flavivirus)	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.6874706031148871	[94,94]	[0,0]	3	hSpCas9	positive selection	3361681
50359044	50359067	14	-	27383988	293T	resistance to West Nile virus (flavivirus)	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.2264895658184215	[178,178]	[0,0]	-1	hSpCas9	positive selection	3361682
50345032	50345055	14	+	27383988	293T	resistance to West Nile virus (flavivirus)	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	1.8650087886670745	[41,41]	[0,0]	7	hSpCas9	positive selection	3361683
50359027	50359050	14	-	26780180	HT29	viability (Avana library 4 designs)	AGTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	0.372695514184776	[]	[]	1	hSpCas9	negative selection	3414550
50341189	50341212	14	-	26780180	HT29	viability (Avana library 4 designs)	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	1.10482216696731	[]	[]	4	hSpCas9	negative selection	3414551
50395704	50395727	14	+	26780180	HT29	viability (Avana library 4 designs)	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.878677149427944	[]	[]	3	hSpCas9	negative selection	3414552
50395703	50395726	14	+	26780180	HT29	viability (Avana library 4 designs)	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	1.08167903383618	[]	[]	4	hSpCas9	negative selection	3414553
50395704	50395727	14	+	26780180	A375	viability (Avana lentiCRISPRv2)	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	5.01141458259363	[]	[]	8	hSpCas9	negative selection	3491122
50395703	50395726	14	+	26780180	A375	viability (Avana lentiCRISPRv2)	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	1.36224471636904	[]	[]	2	hSpCas9	negative selection	3491123
50359027	50359050	14	-	26780180	A375	viability (Avana lentiCRISPRv2)	AGTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	-1.71231783637003	[]	[]	-2	hSpCas9	negative selection	3491124
50341189	50341212	14	-	26780180	A375	viability (Avana lentiCRISPRv2)	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	2.54643764609902	[]	[]	4	hSpCas9	negative selection	3491125
50341200	50341223	14	-	26780180	A375	viability (Avana lentiCRISPRv2)	TGACTACTATACAGACTACGTGG	CDKL1	ENSG00000100490	-2.33898358432322	[]	[]	-3	hSpCas9	negative selection	3491126
50359093	50359116	14	-	26780180	A375	viability (Avana lentiCRISPRv2)	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	3.56444442528259	[]	[]	5	hSpCas9	negative selection	3491127
50395704	50395727	14	+	26780180	A375	viability (Avana lentiGuide)	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-2.56238586713159	[]	[]	-4	hSpCas9	negative selection	3599781
50395703	50395726	14	+	26780180	A375	viability (Avana lentiGuide)	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	1.65009976701796	[]	[]	1	hSpCas9	negative selection	3599782
50359027	50359050	14	-	26780180	A375	viability (Avana lentiGuide)	AGTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	-6.87195137019432	[]	[]	-9	hSpCas9	negative selection	3599783
50341189	50341212	14	-	26780180	A375	viability (Avana lentiGuide)	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	2.03621942143094	[]	[]	2	hSpCas9	negative selection	3599784
50341200	50341223	14	-	26780180	A375	viability (Avana lentiGuide)	TGACTACTATACAGACTACGTGG	CDKL1	ENSG00000100490	7.55827313134936	[]	[]	6	hSpCas9	negative selection	3599785
50359093	50359116	14	-	26780180	A375	viability (Avana lentiGuide)	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	-3.38359697632749	[]	[]	-6	hSpCas9	negative selection	3599786
50395704	50395727	14	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.2571424264724208	[5]	[6,5]	7	hSpCas9	positive selection	3708440
50395703	50395726	14	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.09251513930285944	[5]	[5,3]	-1	hSpCas9	positive selection	3708441
50359027	50359050	14	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	-0.08151598341770838	[4]	[4,3]	-1	hSpCas9	positive selection	3708442
50341189	50341212	14	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	0.26681847096193057	[4]	[5,5]	7	hSpCas9	positive selection	3708443
50341200	50341223	14	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TGACTACTATACAGACTACGTGG	CDKL1	ENSG00000100490	-0.2962004661051184	[6]	[4,4]	-4	hSpCas9	positive selection	3708444
50359093	50359116	14	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	0.18142383492035252	[4]	[7,3]	5	hSpCas9	positive selection	3708445
50395704	50395727	14	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.10332320347083318	[5]	[4,3]	-1	hSpCas9	positive selection	3817047
50395703	50395726	14	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.1874484557241983	[5]	[3,3]	-3	hSpCas9	positive selection	3817048
50359027	50359050	14	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	-0.563392631238741	[4]	[2,1]	-6	hSpCas9	positive selection	3817049
50341189	50341212	14	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	0.12252178202686814	[5]	[5,4]	2	hSpCas9	positive selection	3817050
50341200	50341223	14	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TGACTACTATACAGACTACGTGG	CDKL1	ENSG00000100490	-0.08575067258833532	[5]	[3,4]	-1	hSpCas9	positive selection	3817051
50359093	50359116	14	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	0.045304760932718416	[5]	[5,3]	1	hSpCas9	positive selection	3817052
50338975	50338998	14	-	26780180	A375	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	1.06874270538431	[]	[]	5	hSpCas9	negative selection	3925229
50345025	50345048	14	-	26780180	A375	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.273590765455508	[]	[]	0	hSpCas9	negative selection	3925230
50345032	50345055	14	+	26780180	A375	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	1.46289537253306	[]	[]	8	hSpCas9	negative selection	3925231
50359044	50359067	14	-	26780180	A375	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	1.42547185066443	[]	[]	7	hSpCas9	negative selection	3925232
50338988	50339011	14	+	26780180	A375	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	0.95067963467994	[]	[]	4	hSpCas9	negative selection	3925233
50359116	50359139	14	-	26780180	A375	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	1.54428118814581	[]	[]	8	hSpCas9	negative selection	3925234
50338975	50338998	14	-	26780180	HT29	viability (GeCKOv2 library)	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	1.11475697169215	[]	[]	5	hSpCas9	negative selection	4033195
50345025	50345048	14	-	26780180	HT29	viability (GeCKOv2 library)	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.779338060785668	[]	[]	3	hSpCas9	negative selection	4033196
50345032	50345055	14	+	26780180	HT29	viability (GeCKOv2 library)	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	1.39118240272522	[]	[]	7	hSpCas9	negative selection	4033197
50359044	50359067	14	-	26780180	HT29	viability (GeCKOv2 library)	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	1.66881904323648	[]	[]	8	hSpCas9	negative selection	4033198
50338988	50339011	14	+	26780180	HT29	viability (GeCKOv2 library)	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	0.7813396111441	[]	[]	3	hSpCas9	negative selection	4033199
50359116	50359139	14	-	26780180	HT29	viability (GeCKOv2 library)	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.911197194183343	[]	[]	4	hSpCas9	negative selection	4033200
50359093	50359116	14	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	0.1082300791473611	[2]	[0,2]	2	hSpCas9	positive selection	4126685
50359044	50359067	14	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.26166657338567934	[3]	[1,1]	-6	hSpCas9	positive selection	4126686
50342149	50342172	14	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GTGATTAAGCTTTGTGACTTTGG	CDKL1	ENSG00000100490	0.05061074344878144	[4]	[2,3]	1	hSpCas9	positive selection	4126687
50342179	50342202	14	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TTCGTGATGAGGATATTTTCTGG	CDKL1	ENSG00000100490	0.37983347665783507	[3]	[3,3]	8	hSpCas9	positive selection	4126688
50359093	50359116	14	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	-0.538622766231275	[2]	[0,0,0,0]	-7	hSpCas9	positive selection	4190707
50359044	50359067	14	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	0.811742986138887	[3]	[0,0,0,4]	5	hSpCas9	positive selection	4190708
50342149	50342172	14	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GTGATTAAGCTTTGTGACTTTGG	CDKL1	ENSG00000100490	0.9993745469011878	[3]	[1,3,2,3]	7	hSpCas9	positive selection	4190709
50342179	50342202	14	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TTCGTGATGAGGATATTTTCTGG	CDKL1	ENSG00000100490	1.2151215933799313	[4]	[3,0,3,5]	8	hSpCas9	positive selection	4190710
50359116	50359139	14	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	-0.2115282077572058	[4]	[3,1]	-4	hSpCas9	positive selection	4262503
50345025	50345048	14	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.35237328582816646	[3]	[3,3]	7	hSpCas9	positive selection	4262504
50338988	50339011	14	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	0.41238996409098894	[3]	[3,3]	8	hSpCas9	positive selection	4262505
50338975	50338998	14	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.43466489956520427	[1]	[1,2]	8	hSpCas9	positive selection	4326781
50359044	50359067	14	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	0.3014181276397625	[3]	[2,3]	6	hSpCas9	positive selection	4326782
50345032	50345055	14	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.17133745653350924	[2]	[2,0]	-3	hSpCas9	positive selection	4326783
50341124	50341146	14	+	27760321	OCIAML3	viability	ATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.6905952778490744	[873,717]	[923,1098]	7	hSpCas9	negative selection	4388121
50341192	50341214	14	-	27760321	OCIAML3	viability	TACAGACTACGTGGCTACCAGG	CDKL1	ENSG00000100490	0.11025578310277401	[654,510]	[358,657]	1	hSpCas9	negative selection	4388122
50342169	50342191	14	+	27760321	OCIAML3	viability	CACGGAATGTTTCGTGATGAGG	CDKL1	ENSG00000100490	0.291360812879669	[497,501]	[412,567]	3	hSpCas9	negative selection	4388123
50359027	50359049	14	-	27760321	OCIAML3	viability	GTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	-0.46038820165292016	[135,82]	[55,67]	-5	hSpCas9	negative selection	4388124
50395705	50395727	14	+	27760321	OCIAML3	viability	AGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.26615039041307936	[320,227]	[254,255]	3	hSpCas9	negative selection	4388125
50341124	50341146	14	+	27760321	OCIAML2	viability	ATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.6100547593344593	[873,717]	[890,1092]	8	hSpCas9	negative selection	4471584
50341192	50341214	14	-	27760321	OCIAML2	viability	TACAGACTACGTGGCTACCAGG	CDKL1	ENSG00000100490	0.39272090578103297	[654,510]	[519,739]	5	hSpCas9	negative selection	4471585
50342169	50342191	14	+	27760321	OCIAML2	viability	CACGGAATGTTTCGTGATGAGG	CDKL1	ENSG00000100490	0.4870373145909772	[497,501]	[533,614]	6	hSpCas9	negative selection	4471586
50359027	50359049	14	-	27760321	OCIAML2	viability	GTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	0.6790329091855276	[135,82]	[132,147]	8	hSpCas9	negative selection	4471587
50395705	50395727	14	+	27760321	OCIAML2	viability	AGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.32342831617667556	[320,227]	[245,312]	4	hSpCas9	negative selection	4471588
50341124	50341146	14	+	27760321	MV411	viability	ATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.9871633284636473	[873,717]	[1156,854]	7	hSpCas9	negative selection	4555047
50341192	50341214	14	-	27760321	MV411	viability	TACAGACTACGTGGCTACCAGG	CDKL1	ENSG00000100490	1.0056772261314828	[654,510]	[988,433]	7	hSpCas9	negative selection	4555048
50342169	50342191	14	+	27760321	MV411	viability	CACGGAATGTTTCGTGATGAGG	CDKL1	ENSG00000100490	-0.36329276441704117	[497,501]	[47,571]	-3	hSpCas9	negative selection	4555049
50359027	50359049	14	-	27760321	MV411	viability	GTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	-2.4516504594511623	[135,82]	[0,30]	-9	hSpCas9	negative selection	4555050
50395705	50395727	14	+	27760321	MV411	viability	AGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.9988120534240907	[320,227]	[288,461]	7	hSpCas9	negative selection	4555051
50341124	50341146	14	+	27760321	HL60	viability	ATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.5941395795414376	[873,717]	[923,1032]	7	hSpCas9	negative selection	4638510
50341192	50341214	14	-	27760321	HL60	viability	TACAGACTACGTGGCTACCAGG	CDKL1	ENSG00000100490	0.17753621209026466	[654,510]	[531,537]	2	hSpCas9	negative selection	4638511
50342169	50342191	14	+	27760321	HL60	viability	CACGGAATGTTTCGTGATGAGG	CDKL1	ENSG00000100490	1.0706633607127003	[497,501]	[760,966]	9	hSpCas9	negative selection	4638512
50359027	50359049	14	-	27760321	HL60	viability	GTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	-0.2094991976821725	[135,82]	[61,90]	-2	hSpCas9	negative selection	4638513
50395705	50395727	14	+	27760321	HL60	viability	AGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.340139774539856	[320,227]	[175,391]	4	hSpCas9	negative selection	4638514
50341124	50341146	14	+	27760321	HT1080	viability	ATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	1.671979389141737	[717,559]	[760,865]	8	hSpCas9	negative selection	4721973
50341192	50341214	14	-	27760321	HT1080	viability	TACAGACTACGTGGCTACCAGG	CDKL1	ENSG00000100490	0.43309000224514954	[510,398]	[238,250]	2	hSpCas9	negative selection	4721974
50342169	50342191	14	+	27760321	HT1080	viability	CACGGAATGTTTCGTGATGAGG	CDKL1	ENSG00000100490	1.4494232370381483	[501,391]	[703,247]	7	hSpCas9	negative selection	4721975
50359027	50359049	14	-	27760321	HT1080	viability	GTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	0.5796594639734718	[82,64]	[55,30]	3	hSpCas9	negative selection	4721976
50395705	50395727	14	+	27760321	HT1080	viability	AGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	1.9058269370864585	[227,177]	[187,428]	8	hSpCas9	negative selection	4721977
50341124	50341146	14	+	27760321	HT29	viability after 7 days	ATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	-0.0025258299948488494	[717,559]	[791,807,853]	0	hSpCas9	negative selection	4805436
50341192	50341214	14	-	27760321	HT29	viability after 7 days	TACAGACTACGTGGCTACCAGG	CDKL1	ENSG00000100490	-0.04501702978080008	[510,398]	[513,301,866]	0	hSpCas9	negative selection	4805437
50342169	50342191	14	+	27760321	HT29	viability after 7 days	CACGGAATGTTTCGTGATGAGG	CDKL1	ENSG00000100490	0.14953175193411566	[501,391]	[594,624,683]	2	hSpCas9	negative selection	4805438
50359027	50359049	14	-	27760321	HT29	viability after 7 days	GTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	0.6081385441728868	[82,64]	[204,140,98]	8	hSpCas9	negative selection	4805439
50395705	50395727	14	+	27760321	HT29	viability after 7 days	AGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.06744774476013926	[227,177]	[284,312,156]	-1	hSpCas9	negative selection	4805440
50341124	50341146	14	+	27760321	HT29	viability after 25 days	ATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.7208641088435874	[717,559]	[1166,1189,1259]	7	hSpCas9	negative selection	4888899
50341192	50341214	14	-	27760321	HT29	viability after 25 days	TACAGACTACGTGGCTACCAGG	CDKL1	ENSG00000100490	-0.1817298370116752	[510,398]	[428,484,462]	-2	hSpCas9	negative selection	4888900
50342169	50342191	14	+	27760321	HT29	viability after 25 days	CACGGAATGTTTCGTGATGAGG	CDKL1	ENSG00000100490	0.5984321648418456	[501,391]	[836,706,770]	6	hSpCas9	negative selection	4888901
50359027	50359049	14	-	27760321	HT29	viability after 25 days	GTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	0.665720005579473	[82,64]	[101,136,168]	7	hSpCas9	negative selection	4888902
50395705	50395727	14	+	27760321	HT29	viability after 25 days	AGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.17031267920928717	[227,177]	[176,124,330]	-2	hSpCas9	negative selection	4888903
50341124	50341146	14	+	27760321	HT29	viability after 22 days	ATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.32881261540597295	[717,559]	[790,856,1140]	3	hSpCas9	negative selection	4972362
50341192	50341214	14	-	27760321	HT29	viability after 22 days	TACAGACTACGTGGCTACCAGG	CDKL1	ENSG00000100490	0.320401494609823	[510,398]	[690,676,600]	3	hSpCas9	negative selection	4972363
50342169	50342191	14	+	27760321	HT29	viability after 22 days	CACGGAATGTTTCGTGATGAGG	CDKL1	ENSG00000100490	0.2961279593587716	[501,391]	[592,743,566]	3	hSpCas9	negative selection	4972364
50359027	50359049	14	-	27760321	HT29	viability after 22 days	GTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	0.8632886474799919	[82,64]	[189,124,150]	8	hSpCas9	negative selection	4972365
50395705	50395727	14	+	27760321	HT29	viability after 22 days	AGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.05224273960550019	[227,177]	[164,148,367]	0	hSpCas9	negative selection	4972366
50341124	50341146	14	+	27760321	HT29	viability after 19 days	ATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.879062321756193	[717,559]	[1278,1417,1327]	8	hSpCas9	negative selection	5055825
50341192	50341214	14	-	27760321	HT29	viability after 19 days	TACAGACTACGTGGCTACCAGG	CDKL1	ENSG00000100490	-0.41382853460672336	[510,398]	[533,513,147]	-4	hSpCas9	negative selection	5055826
50342169	50342191	14	+	27760321	HT29	viability after 19 days	CACGGAATGTTTCGTGATGAGG	CDKL1	ENSG00000100490	0.23369459911595564	[501,391]	[814,773,249]	2	hSpCas9	negative selection	5055827
50359027	50359049	14	-	27760321	HT29	viability after 19 days	GTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	0.7038857975030604	[82,64]	[168,221,29]	7	hSpCas9	negative selection	5055828
50395705	50395727	14	+	27760321	HT29	viability after 19 days	AGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.015630260440259613	[227,177]	[230,308,151]	0	hSpCas9	negative selection	5055829
50341124	50341146	14	+	27760321	HT29	viability after 16 days	ATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.4943118191028568	[717,559]	[1152,918,964]	5	hSpCas9	negative selection	5139288
50341192	50341214	14	-	27760321	HT29	viability after 16 days	TACAGACTACGTGGCTACCAGG	CDKL1	ENSG00000100490	0.3143838242545774	[510,398]	[446,685,746]	3	hSpCas9	negative selection	5139289
50342169	50342191	14	+	27760321	HT29	viability after 16 days	CACGGAATGTTTCGTGATGAGG	CDKL1	ENSG00000100490	0.5145563512351381	[501,391]	[524,650,950]	6	hSpCas9	negative selection	5139290
50359027	50359049	14	-	27760321	HT29	viability after 16 days	GTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	0.5555798337632181	[82,64]	[76,78,205]	6	hSpCas9	negative selection	5139291
50395705	50395727	14	+	27760321	HT29	viability after 16 days	AGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.022478298284184017	[227,177]	[331,176,193]	0	hSpCas9	negative selection	5139292
50341124	50341146	14	+	27760321	HT29	viability after 13 days	ATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.6222731576002976	[717,559]	[1346,960,1115]	7	hSpCas9	negative selection	5222751
50341192	50341214	14	-	27760321	HT29	viability after 13 days	TACAGACTACGTGGCTACCAGG	CDKL1	ENSG00000100490	0.25446132116012393	[510,398]	[716,648,528]	3	hSpCas9	negative selection	5222752
50342169	50342191	14	+	27760321	HT29	viability after 13 days	CACGGAATGTTTCGTGATGAGG	CDKL1	ENSG00000100490	0.5905781105189247	[501,391]	[657,837,842]	7	hSpCas9	negative selection	5222753
50359027	50359049	14	-	27760321	HT29	viability after 13 days	GTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	0.37678773185213	[82,64]	[80,115,135]	5	hSpCas9	negative selection	5222754
50395705	50395727	14	+	27760321	HT29	viability after 13 days	AGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.2086305247912087	[227,177]	[206,293,312]	2	hSpCas9	negative selection	5222755
50341124	50341146	14	+	27760321	HT29	viability after 10 days	ATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.3629658569032115	[717,559]	[946,1163,971]	5	hSpCas9	negative selection	5306214
50341192	50341214	14	-	27760321	HT29	viability after 10 days	TACAGACTACGTGGCTACCAGG	CDKL1	ENSG00000100490	0.17188493790923082	[510,398]	[476,915,536]	2	hSpCas9	negative selection	5306215
50342169	50342191	14	+	27760321	HT29	viability after 10 days	CACGGAATGTTTCGTGATGAGG	CDKL1	ENSG00000100490	-0.07943433047754728	[501,391]	[638,466,477]	-1	hSpCas9	negative selection	5306216
50359027	50359049	14	-	27760321	HT29	viability after 10 days	GTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	0.9967946279720024	[82,64]	[255,107,186]	9	hSpCas9	negative selection	5306217
50395705	50395727	14	+	27760321	HT29	viability after 10 days	AGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.026835370092746613	[227,177]	[137,411,201]	0	hSpCas9	negative selection	5306218
50341124	50341146	14	+	27760321	MOLM13	viability	ATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	1.392408410181647	[873,717]	[1551,850]	8	hSpCas9	negative selection	5389677
50341192	50341214	14	-	27760321	MOLM13	viability	TACAGACTACGTGGCTACCAGG	CDKL1	ENSG00000100490	0.27498901855300956	[654,510]	[505,300]	1	hSpCas9	negative selection	5389678
50342169	50342191	14	+	27760321	MOLM13	viability	CACGGAATGTTTCGTGATGAGG	CDKL1	ENSG00000100490	0.8551053718500655	[497,501]	[422,587]	6	hSpCas9	negative selection	5389679
50359027	50359049	14	-	27760321	MOLM13	viability	GTTGGACAGATACCAAAGAGGG	CDKL1	ENSG00000100490	1.88949612275459	[135,82]	[290,168]	9	hSpCas9	negative selection	5389680
50395705	50395727	14	+	27760321	MOLM13	viability	AGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	1.0495666734095375	[320,227]	[166,444]	7	hSpCas9	negative selection	5389681
50396825	50396848	14	+	27661255	K562	viability	GCGCCGCGGCGGTCAGGGACGGG	CDKL1	ENSG00000100490	-0.030396460228556688	[279,218]	[222,172]	-1	dCas9-KRAB	negative selection	5469953
50396893	50396916	14	+	27661255	K562	viability	GCTCGGCCCGCGATCCCTATGGG	CDKL1	ENSG00000100490	-0.057852531578002214	[736,594]	[579,455]	-2	dCas9-KRAB	negative selection	5469954
50396907	50396930	14	-	27661255	K562	viability	GGCGGGAGCCGGTTCCCATAGGG	CDKL1	ENSG00000100490	0.2617539867679041	[488,507]	[529,431]	8	dCas9-KRAB	negative selection	5469955
50396928	50396951	14	-	27661255	K562	viability	GCCCCGCCCAGGCAGACCCGGGG	CDKL1	ENSG00000100490	-0.12271750403134085	[349,289]	[254,218]	-4	dCas9-KRAB	negative selection	5469956
50359116	50359139	14	-	27260156	BXPC3	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.07139952948786044	[1103]	[1237,1217,1045,1351]	1	hSpCas9	negative selection	5534963
50345025	50345048	14	-	27260156	BXPC3	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.02135918516789237	[841]	[773,865,896,1066]	0	hSpCas9	negative selection	5534964
50338988	50339011	14	+	27260156	BXPC3	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.1572836702653735	[629]	[580,461,635,702]	-4	hSpCas9	negative selection	5534965
50338975	50338998	14	-	27260156	BXPC3	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.11761302692806574	[156]	[201,129,166,216]	2	hSpCas9	negative selection	5599241
50359044	50359067	14	-	27260156	BXPC3	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.10385453263128447	[634]	[655,554,561,702]	-2	hSpCas9	negative selection	5599242
50345032	50345055	14	+	27260156	BXPC3	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.5636452433853247	[246]	[138,125,201,246]	-8	hSpCas9	negative selection	5599243
50359116	50359139	14	-	27260156	A673	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.10199786465600913	[1103]	[1558,1304,1344,1502]	2	hSpCas9	negative selection	5656214
50345025	50345048	14	-	27260156	A673	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	-0.04294640314543896	[841]	[1138,836,876,1099]	-1	hSpCas9	negative selection	5656215
50338988	50339011	14	+	27260156	A673	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.2657832818850341	[629]	[813,620,494,606]	-6	hSpCas9	negative selection	5656216
50338975	50338998	14	-	27260156	A673	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	-0.020855822186439887	[156]	[188,129,256,166]	0	hSpCas9	negative selection	5720492
50359044	50359067	14	-	27260156	A673	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.06696531147178109	[634]	[707,752,764,677]	-2	hSpCas9	negative selection	5720493
50345032	50345055	14	+	27260156	A673	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.7153693293539378	[246]	[170,136,228,184]	-9	hSpCas9	negative selection	5720494
50359116	50359139	14	-	27260156	A375	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.3602385685578733	[1103]	[1548,1887,1535,1670]	5	hSpCas9	negative selection	5777465
50345025	50345048	14	-	27260156	A375	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.2228913192805475	[841]	[1480,1399,1056,735]	3	hSpCas9	negative selection	5777466
50338988	50339011	14	+	27260156	A375	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	0.062346891323953046	[629]	[722,837,854,674]	0	hSpCas9	negative selection	5777467
50338975	50338998	14	-	27260156	A375	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.009467445959373322	[156]	[121,319,221,101]	0	hSpCas9	negative selection	5841743
50359044	50359067	14	-	27260156	A375	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	0.03839286550511539	[634]	[614,614,1138,664]	0	hSpCas9	negative selection	5841744
50345032	50345055	14	+	27260156	A375	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.2511582466365536	[246]	[263,245,287,178]	-4	hSpCas9	negative selection	5841745
50359116	50359139	14	-	27260156	COLO741	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.012447618544939365	[1103]	[1725,1373,1206]	0	hSpCas9	negative selection	5898716
50345025	50345048	14	-	27260156	COLO741	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	-0.06037761387453522	[841]	[999,1235,866]	-1	hSpCas9	negative selection	5898717
50338988	50339011	14	+	27260156	COLO741	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.034266805704229575	[629]	[828,814,720]	0	hSpCas9	negative selection	5898718
50338975	50338998	14	-	27260156	COLO741	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.323166944939725	[156]	[286,212,254]	6	hSpCas9	negative selection	5962994
50359044	50359067	14	-	27260156	COLO741	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	0.047643622511256645	[634]	[989,761,778]	1	hSpCas9	negative selection	5962995
50345032	50345055	14	+	27260156	COLO741	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.5446547857802868	[246]	[257,232,164]	-8	hSpCas9	negative selection	5962996
50359116	50359139	14	-	27260156	CAL120	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	-0.09887882681925264	[1103]	[1252,1341,1248]	-1	hSpCas9	negative selection	6019967
50345025	50345048	14	-	27260156	CAL120	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.22385676398276022	[841]	[1963,883,938]	3	hSpCas9	negative selection	6019968
50338988	50339011	14	+	27260156	CAL120	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	0.02889055019988568	[629]	[907,572,931]	0	hSpCas9	negative selection	6019969
50338975	50338998	14	-	27260156	CAL120	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.48400670485940545	[156]	[239,489,87]	7	hSpCas9	negative selection	6084245
50359044	50359067	14	-	27260156	CAL120	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.4394158178536366	[634]	[520,768,450]	-6	hSpCas9	negative selection	6084246
50345032	50345055	14	+	27260156	CAL120	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-1.0106203875924293	[246]	[137,85,229]	-8	hSpCas9	negative selection	6084247
50359116	50359139	14	-	27260156	CADOES1	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.1576542446858169	[1103]	[1163,1087,1163,1165]	2	hSpCas9	negative selection	6141218
50345025	50345048	14	-	27260156	CADOES1	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.07951961065718283	[841]	[866,681,996,760]	1	hSpCas9	negative selection	6141219
50338988	50339011	14	+	27260156	CADOES1	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.08775843529618355	[629]	[667,655,492,381]	-1	hSpCas9	negative selection	6141220
50338975	50338998	14	-	27260156	CADOES1	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.05220378388629676	[156]	[132,173,113,185]	0	hSpCas9	negative selection	6205496
50359044	50359067	14	-	27260156	CADOES1	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.34858197868425794	[634]	[458,422,488,484]	-6	hSpCas9	negative selection	6205497
50345032	50345055	14	+	27260156	CADOES1	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.4475375203422909	[246]	[194,147,103,228]	-7	hSpCas9	negative selection	6205498
50359116	50359139	14	-	27260156	EWS502	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.13052351184121536	[1103]	[1307,1389,1307,1087]	2	hSpCas9	negative selection	6262469
50345025	50345048	14	-	27260156	EWS502	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	-0.028455022016699916	[841]	[916,834,679,1069]	0	hSpCas9	negative selection	6262470
50338988	50339011	14	+	27260156	EWS502	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.2098678810944573	[629]	[603,604,517,572]	-4	hSpCas9	negative selection	6262471
50338975	50338998	14	-	27260156	EWS502	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	-0.12378029481368769	[156]	[103,167,169,174]	-2	hSpCas9	negative selection	6326747
50359044	50359067	14	-	27260156	EWS502	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.3074616100012637	[634]	[533,486,502,658]	-5	hSpCas9	negative selection	6326748
50345032	50345055	14	+	27260156	EWS502	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.754140829911697	[246]	[73,156,113,293]	-8	hSpCas9	negative selection	6326749
50359116	50359139	14	-	27260156	EW8	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.14095888781093224	[1103]	[1083,944,1063,847]	2	hSpCas9	negative selection	6383720
50345025	50345048	14	-	27260156	EW8	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	-0.03009463260188039	[841]	[640,584,544,916]	0	hSpCas9	negative selection	6383721
50338988	50339011	14	+	27260156	EW8	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.20653637886458245	[629]	[580,407,423,373]	-4	hSpCas9	negative selection	6383722
50338975	50338998	14	-	27260156	EW8	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	-0.05746511546843913	[156]	[94,77,105,208]	-1	hSpCas9	negative selection	6447998
50359044	50359067	14	-	27260156	EW8	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.030469450997983538	[634]	[514,542,422,547]	0	hSpCas9	negative selection	6447999
50345032	50345055	14	+	27260156	EW8	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-1.0086163098784955	[246]	[92,96,104,100]	-9	hSpCas9	negative selection	6448000
50359116	50359139	14	-	27260156	CORL105	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.11465443102694728	[1103]	[1322,1239,1771,1320]	2	hSpCas9	negative selection	6504971
50345025	50345048	14	-	27260156	CORL105	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.01651085900256033	[841]	[1005,754,990,1238]	0	hSpCas9	negative selection	6504972
50338988	50339011	14	+	27260156	CORL105	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.4666223115378839	[629]	[658,449,684,370]	-7	hSpCas9	negative selection	6504973
50338975	50338998	14	-	27260156	CORL105	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	-0.04185708770771157	[156]	[210,104,287,129]	-1	hSpCas9	negative selection	6569249
50359044	50359067	14	-	27260156	CORL105	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.4570356629564968	[634]	[493,606,596,473]	-7	hSpCas9	negative selection	6569250
50345032	50345055	14	+	27260156	CORL105	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.47868634720682035	[246]	[123,123,425,188]	-7	hSpCas9	negative selection	6569251
50359116	50359139	14	-	27260156	HS294T	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.10993549060700514	[1103]	[311,469,608,464]	1	hSpCas9	negative selection	6626222
50345025	50345048	14	-	27260156	HS294T	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.44728493749691056	[841]	[466,298,450,582]	6	hSpCas9	negative selection	6626223
50338988	50339011	14	+	27260156	HS294T	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	0.2114615623401993	[629]	[212,357,274,285]	3	hSpCas9	negative selection	6626224
50338975	50338998	14	-	27260156	HS294T	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.21548372842932428	[156]	[146,40,27,56]	3	hSpCas9	negative selection	6690500
50359044	50359067	14	-	27260156	HS294T	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	0.2218365244890344	[634]	[228,273,312,343]	3	hSpCas9	negative selection	6690501
50345032	50345055	14	+	27260156	HS294T	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.9453487539353966	[246]	[29,30,73,68]	-8	hSpCas9	negative selection	6690502
50359116	50359139	14	-	27260156	HCC44	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.20368391593145097	[1103]	[1249,1280,2023,1295]	3	hSpCas9	negative selection	6747473
50345025	50345048	14	-	27260156	HCC44	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	-0.0556400934016521	[841]	[671,1132,989,824]	-1	hSpCas9	negative selection	6747474
50338988	50339011	14	+	27260156	HCC44	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.22523213679938175	[629]	[546,426,754,744]	-4	hSpCas9	negative selection	6747475
50338975	50338998	14	-	27260156	HCC44	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	-0.04986094347015135	[156]	[111,85,333,186]	-1	hSpCas9	negative selection	6811751
50359044	50359067	14	-	27260156	HCC44	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.3339103441993512	[634]	[607,418,578,690]	-5	hSpCas9	negative selection	6811752
50345032	50345055	14	+	27260156	HCC44	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-1.188308877106786	[246]	[154,66,181,106]	-9	hSpCas9	negative selection	6811753
50359116	50359139	14	-	27260156	G402	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	-0.05577121220896242	[1103]	[1123,1437,1527,1082]	0	hSpCas9	negative selection	6868724
50345025	50345048	14	-	27260156	G402	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.030818275547869978	[841]	[990,1386,704,1118]	0	hSpCas9	negative selection	6868725
50338988	50339011	14	+	27260156	G402	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.003694859560325503	[629]	[804,860,746,666]	0	hSpCas9	negative selection	6868726
50338975	50338998	14	-	27260156	G402	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	-0.1877715875544368	[156]	[307,112,224,48]	-2	hSpCas9	negative selection	6933002
50359044	50359067	14	-	27260156	G402	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.1768010370159689	[634]	[725,448,1118,448]	-2	hSpCas9	negative selection	6933003
50345032	50345055	14	+	27260156	G402	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.46539472196165077	[246]	[256,212,303,108]	-5	hSpCas9	negative selection	6933004
50359116	50359139	14	-	27260156	L33	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.15882505576472106	[1103]	[1288,498,751,1224]	3	hSpCas9	negative selection	6989975
50345025	50345048	14	-	27260156	L33	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.12901352943465982	[841]	[927,341,617,936]	3	hSpCas9	negative selection	6989976
50338988	50339011	14	+	27260156	L33	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.07567333216784389	[629]	[692,213,397,540]	-2	hSpCas9	negative selection	6989977
50338975	50338998	14	-	27260156	L33	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	-0.16300456716909517	[156]	[147,51,83,151]	-4	hSpCas9	negative selection	7054253
50359044	50359067	14	-	27260156	L33	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	0.18329678483758333	[634]	[607,286,472,824]	4	hSpCas9	negative selection	7054254
50345032	50345055	14	+	27260156	L33	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.4506697170290379	[246]	[154,88,92,202]	-8	hSpCas9	negative selection	7054255
50359116	50359139	14	-	27260156	K562	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	-0.19002204071980833	[1103]	[1139,959,765,621]	-2	hSpCas9	negative selection	7111226
50345025	50345048	14	-	27260156	K562	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.3073879979957268	[841]	[965,876,837,1004]	4	hSpCas9	negative selection	7111227
50338988	50339011	14	+	27260156	K562	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	0.2181794336259133	[629]	[1085,360,548,625]	2	hSpCas9	negative selection	7111228
50338975	50338998	14	-	27260156	K562	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.3809746275438952	[156]	[259,164,137,168]	5	hSpCas9	negative selection	7175504
50359044	50359067	14	-	27260156	K562	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.2509687222787295	[634]	[534,627,350,399]	-3	hSpCas9	negative selection	7175505
50345032	50345055	14	+	27260156	K562	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-1.1060373344292782	[246]	[101,115,43,140]	-8	hSpCas9	negative selection	7175506
50359116	50359139	14	-	27260156	HT29	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.23042667790659022	[1103]	[1705,1694,1512,1412]	4	hSpCas9	negative selection	7232477
50345025	50345048	14	-	27260156	HT29	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.08573100073914508	[841]	[1008,1215,1289,855]	1	hSpCas9	negative selection	7232478
50338988	50339011	14	+	27260156	HT29	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	0.12376750181862906	[629]	[751,879,1084,636]	2	hSpCas9	negative selection	7232479
50338975	50338998	14	-	27260156	HT29	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.2334231953902337	[156]	[159,330,282,136]	4	hSpCas9	negative selection	7296755
50359044	50359067	14	-	27260156	HT29	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	0.0036292428276865074	[634]	[907,729,860,616]	0	hSpCas9	negative selection	7296756
50345032	50345055	14	+	27260156	HT29	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.443757889634687	[246]	[225,237,195,222]	-7	hSpCas9	negative selection	7296757
50359116	50359139	14	-	27260156	MHHES1	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.3131866263049692	[1103]	[1820,1914,1565,1033]	5	hSpCas9	negative selection	7353728
50345025	50345048	14	-	27260156	MHHES1	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.33737412813878564	[841]	[1442,1309,1113,987]	6	hSpCas9	negative selection	7353729
50338988	50339011	14	+	27260156	MHHES1	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.21523313870923297	[629]	[690,719,528,529]	-4	hSpCas9	negative selection	7353730
50338975	50338998	14	-	27260156	MHHES1	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.12658022930373058	[156]	[174,272,191,144]	2	hSpCas9	negative selection	7418006
50359044	50359067	14	-	27260156	MHHES1	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.1874301725004901	[634]	[734,641,515,619]	-4	hSpCas9	negative selection	7418007
50345032	50345055	14	+	27260156	MHHES1	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.28852365100719135	[246]	[295,166,278,177]	-5	hSpCas9	negative selection	7418008
50359116	50359139	14	-	27260156	MEWO	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.23961182115134605	[1103]	[1706,1136,908]	5	hSpCas9	negative selection	7474979
50345025	50345048	14	-	27260156	MEWO	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	-0.01861836834474584	[841]	[796,675,863]	0	hSpCas9	negative selection	7474980
50338988	50339011	14	+	27260156	MEWO	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	0.11472873774452153	[629]	[666,639,612]	2	hSpCas9	negative selection	7474981
50338975	50338998	14	-	27260156	MEWO	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.32061715940360447	[156]	[237,150,171]	7	hSpCas9	negative selection	7539257
50359044	50359067	14	-	27260156	MEWO	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	0.10120901199594895	[634]	[741,619,569]	2	hSpCas9	negative selection	7539258
50345032	50345055	14	+	27260156	MEWO	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.6032476088382803	[246]	[164,112,180]	-8	hSpCas9	negative selection	7539259
50359116	50359139	14	-	27260156	LNCAPCLONEFGC	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.14041543258423683	[1103]	[937,1051,1378,1086]	2	hSpCas9	negative selection	7596230
50345025	50345048	14	-	27260156	LNCAPCLONEFGC	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	-0.14348857099057588	[841]	[614,829,704,605]	-2	hSpCas9	negative selection	7596231
50338988	50339011	14	+	27260156	LNCAPCLONEFGC	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.17946546807324615	[629]	[511,344,727,473]	-3	hSpCas9	negative selection	7596232
50338975	50338998	14	-	27260156	LNCAPCLONEFGC	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	-0.25092977625405366	[156]	[90,74,149,169]	-4	hSpCas9	negative selection	7660508
50359044	50359067	14	-	27260156	LNCAPCLONEFGC	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.20906131506801007	[634]	[442,452,691,434]	-3	hSpCas9	negative selection	7660509
50345032	50345055	14	+	27260156	LNCAPCLONEFGC	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.44452185927722865	[246]	[122,196,216,126]	-6	hSpCas9	negative selection	7660510
50359116	50359139	14	-	27260156	PANC0327	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	-0.20572408568171618	[1103]	[787,669,771,1188]	-3	hSpCas9	negative selection	7717481
50345025	50345048	14	-	27260156	PANC0327	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	-0.2163476053937241	[841]	[675,431,713,782]	-3	hSpCas9	negative selection	7717482
50338988	50339011	14	+	27260156	PANC0327	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.5123781457540889	[629]	[315,288,730,240]	-6	hSpCas9	negative selection	7717483
50338975	50338998	14	-	27260156	PANC0327	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.04151556869131112	[156]	[155,99,262,61]	0	hSpCas9	negative selection	7781759
50359044	50359067	14	-	27260156	PANC0327	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.1824039068178701	[634]	[624,347,547,496]	-3	hSpCas9	negative selection	7781760
50345032	50345055	14	+	27260156	PANC0327	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	0.41841634577461406	[246]	[456,122,195,431]	6	hSpCas9	negative selection	7781761
50359116	50359139	14	-	27260156	NCIH2009	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.10400015789384542	[1103]	[1754,1474,1762]	1	hSpCas9	negative selection	7838732
50345025	50345048	14	-	27260156	NCIH2009	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.3561509223199122	[841]	[1779,1398,1391]	5	hSpCas9	negative selection	7838733
50338988	50339011	14	+	27260156	NCIH2009	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.03882541297006592	[629]	[1109,806,702]	0	hSpCas9	negative selection	7838734
50338975	50338998	14	-	27260156	NCIH2009	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.450587184602961	[156]	[307,322,268]	6	hSpCas9	negative selection	7903010
50359044	50359067	14	-	27260156	NCIH2009	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.22789116242805088	[634]	[1044,768,513]	-3	hSpCas9	negative selection	7903011
50345032	50345055	14	+	27260156	NCIH2009	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	0.3830643612821898	[246]	[517,328,517]	5	hSpCas9	negative selection	7903012
50359116	50359139	14	-	27260156	NCIH1373	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.056563229720865804	[1103]	[1376,1160,1188,381]	0	hSpCas9	negative selection	7959983
50345025	50345048	14	-	27260156	NCIH1373	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.5179490179662092	[841]	[1277,1068,1298,472]	5	hSpCas9	negative selection	7959984
50338988	50339011	14	+	27260156	NCIH1373	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	0.25258318967363513	[629]	[1494,598,496,238]	2	hSpCas9	negative selection	7959985
50338975	50338998	14	-	27260156	NCIH1373	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	-1.015200082053739	[156]	[78,172,58,5]	-8	hSpCas9	negative selection	8024261
50359044	50359067	14	-	27260156	NCIH1373	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.25435804153523967	[634]	[345,673,526,210]	-3	hSpCas9	negative selection	8024262
50345032	50345055	14	+	27260156	NCIH1373	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	0.0127213759625171	[246]	[639,110,205,60]	0	hSpCas9	negative selection	8024263
50359116	50359139	14	-	27260156	PATU8902	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.4120959880935884	[1103]	[2359,1991,1719,2192]	4	hSpCas9	negative selection	8081234
50345025	50345048	14	-	27260156	PATU8902	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.24459643054656444	[841]	[1915,949,1013,1804]	2	hSpCas9	negative selection	8081235
50338988	50339011	14	+	27260156	PATU8902	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.11228597586958472	[629]	[638,1567,408,722]	-1	hSpCas9	negative selection	8081236
50338975	50338998	14	-	27260156	PATU8902	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.14163761312069734	[156]	[241,375,149,215]	1	hSpCas9	negative selection	8145512
50359044	50359067	14	-	27260156	PATU8902	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.07830234228774624	[634]	[937,904,718,807]	-1	hSpCas9	negative selection	8145513
50345032	50345055	14	+	27260156	PATU8902	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.502145685848518	[246]	[228,139,119,548]	-5	hSpCas9	negative selection	8145514
50359116	50359139	14	-	27260156	PANC1	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	-0.19308831586776876	[1103]	[739,1060,1022,573]	-3	hSpCas9	negative selection	8202485
50345025	50345048	14	-	27260156	PANC1	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.055904754274910484	[841]	[952,1063,451,606]	0	hSpCas9	negative selection	8202486
50338988	50339011	14	+	27260156	PANC1	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.16781011127317796	[629]	[460,597,491,404]	-3	hSpCas9	negative selection	8202487
50338975	50338998	14	-	27260156	PANC1	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.4081719983753682	[156]	[116,194,161,233]	6	hSpCas9	negative selection	8266763
50359044	50359067	14	-	27260156	PANC1	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.06294913501492438	[634]	[555,495,562,467]	-1	hSpCas9	negative selection	8266764
50345032	50345055	14	+	27260156	PANC1	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.35940852243523924	[246]	[190,185,99,181]	-5	hSpCas9	negative selection	8266765
50359116	50359139	14	-	27260156	PANC0813	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	-0.17994392553516425	[1103]	[1208,1096,1235,1046]	-3	hSpCas9	negative selection	8323736
50345025	50345048	14	-	27260156	PANC0813	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.13290087341779488	[841]	[1209,988,931,1208]	2	hSpCas9	negative selection	8323737
50338988	50339011	14	+	27260156	PANC0813	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.091407163482227	[629]	[932,494,808,569]	-1	hSpCas9	negative selection	8323738
50338975	50338998	14	-	27260156	PANC0813	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	-0.11044799344791167	[156]	[118,111,314,134]	-2	hSpCas9	negative selection	8388014
50359044	50359067	14	-	27260156	PANC0813	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.18634950060314756	[634]	[493,748,720,642]	-3	hSpCas9	negative selection	8388015
50345032	50345055	14	+	27260156	PANC0813	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.6181219257281596	[246]	[171,153,230,196]	-7	hSpCas9	negative selection	8388016
50359116	50359139	14	-	27260156	RDES	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	-0.04592668801405497	[1103]	[1052,1044,1320,1574]	0	hSpCas9	negative selection	8444987
50345025	50345048	14	-	27260156	RDES	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.02781462893044251	[841]	[646,1024,1095,1270]	0	hSpCas9	negative selection	8444988
50338988	50339011	14	+	27260156	RDES	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.2742627185509058	[629]	[489,613,653,651]	-5	hSpCas9	negative selection	8444989
50338975	50338998	14	-	27260156	RDES	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.34106112563616975	[156]	[174,258,184,307]	5	hSpCas9	negative selection	8509265
50359044	50359067	14	-	27260156	RDES	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.39059288662841374	[634]	[520,566,489,649]	-6	hSpCas9	negative selection	8509266
50345032	50345055	14	+	27260156	RDES	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.523051874422233	[246]	[187,152,208,248]	-7	hSpCas9	negative selection	8509267
50359116	50359139	14	-	27260156	PC3	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.14285617316831667	[1103]	[914,1020,2138,1145]	3	hSpCas9	negative selection	8566238
50345025	50345048	14	-	27260156	PC3	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.23300955334974782	[841]	[516,841,1952,1150]	5	hSpCas9	negative selection	8566239
50338988	50339011	14	+	27260156	PC3	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.3522261019598524	[629]	[289,559,715,528]	-7	hSpCas9	negative selection	8566240
50338975	50338998	14	-	27260156	PC3	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	-0.40293896394753737	[156]	[105,160,126,66]	-7	hSpCas9	negative selection	8630516
50359044	50359067	14	-	27260156	PC3	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	0.03141081379384225	[634]	[347,793,913,703]	0	hSpCas9	negative selection	8630517
50345032	50345055	14	+	27260156	PC3	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.6874320117195163	[246]	[126,137,254,122]	-9	hSpCas9	negative selection	8630518
50359116	50359139	14	-	27260156	PATU8988T	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.04339811037464392	[1103]	[1214,1395,820,987]	0	hSpCas9	negative selection	8687489
50345025	50345048	14	-	27260156	PATU8988T	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.12312068948614929	[841]	[805,1062,854,832]	2	hSpCas9	negative selection	8687490
50338988	50339011	14	+	27260156	PATU8988T	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.4264709147378393	[629]	[357,418,487,550]	-6	hSpCas9	negative selection	8687491
50338975	50338998	14	-	27260156	PATU8988T	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	-0.14641521372436173	[156]	[132,111,197,98]	-3	hSpCas9	negative selection	8751767
50359044	50359067	14	-	27260156	PATU8988T	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	0.009044001687631587	[634]	[372,654,622,839]	0	hSpCas9	negative selection	8751768
50345032	50345055	14	+	27260156	PATU8988T	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.28475878092659523	[246]	[321,214,126,115]	-5	hSpCas9	negative selection	8751769
50359116	50359139	14	-	27260156	T47D	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.021339369016011966	[1103]	[1307,1320,1198,1395]	0	hSpCas9	negative selection	8808740
50345025	50345048	14	-	27260156	T47D	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.0669002952936022	[841]	[929,1090,1118,959]	1	hSpCas9	negative selection	8808741
50338988	50339011	14	+	27260156	T47D	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.2817763070014555	[629]	[623,510,613,675]	-6	hSpCas9	negative selection	8808742
50338975	50338998	14	-	27260156	T47D	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.09315788146310333	[156]	[201,107,171,309]	2	hSpCas9	negative selection	8873018
50359044	50359067	14	-	27260156	T47D	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.1813752303694427	[634]	[612,520,703,785]	-4	hSpCas9	negative selection	8873019
50345032	50345055	14	+	27260156	T47D	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.6862498929640151	[246]	[169,195,206,138]	-8	hSpCas9	negative selection	8873020
50359116	50359139	14	-	27260156	SU8686	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.13220528647559537	[1103]	[1125,964,1354,1422]	2	hSpCas9	negative selection	8929991
50345025	50345048	14	-	27260156	SU8686	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.3465944692111991	[841]	[908,783,1141,1535]	6	hSpCas9	negative selection	8929992
50338988	50339011	14	+	27260156	SU8686	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.1972651911878191	[629]	[501,501,577,615]	-3	hSpCas9	negative selection	8929993
50338975	50338998	14	-	27260156	SU8686	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.07558901183179034	[156]	[185,198,114,142]	1	hSpCas9	negative selection	8994269
50359044	50359067	14	-	27260156	SU8686	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.30759851560591384	[634]	[409,432,671,547]	-5	hSpCas9	negative selection	8994270
50345032	50345055	14	+	27260156	SU8686	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.062077199587261545	[246]	[214,243,273,199]	-1	hSpCas9	negative selection	8994271
50359116	50359139	14	-	27260156	SKES1	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.0722954642996203	[1103]	[1280,1049,1253,1049]	1	hSpCas9	negative selection	9051242
50345025	50345048	14	-	27260156	SKES1	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	-0.058848268935625	[841]	[771,1020,722,731]	-1	hSpCas9	negative selection	9051243
50338988	50339011	14	+	27260156	SKES1	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.0006276215525883311	[629]	[592,938,528,494]	0	hSpCas9	negative selection	9051244
50338975	50338998	14	-	27260156	SKES1	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	-0.08344241105846595	[156]	[160,115,136,170]	-2	hSpCas9	negative selection	9115520
50359044	50359067	14	-	27260156	SKES1	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.04454485560229687	[634]	[774,682,551,486]	-1	hSpCas9	negative selection	9115521
50345032	50345055	14	+	27260156	SKES1	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.4560924061929754	[246]	[248,142,117,208]	-7	hSpCas9	negative selection	9115522
50359116	50359139	14	-	27260156	TOV112D	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.32771159877984357	[1103]	[1191,1610,1470,1314]	6	hSpCas9	negative selection	9172493
50345025	50345048	14	-	27260156	TOV112D	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	-0.17617974217414967	[841]	[752,922,560,789]	-3	hSpCas9	negative selection	9172494
50338988	50339011	14	+	27260156	TOV112D	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.03527233767987936	[629]	[779,615,542,538]	0	hSpCas9	negative selection	9172495
50338975	50338998	14	-	27260156	TOV112D	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	0.0027047848948327236	[156]	[91,163,104,261]	0	hSpCas9	negative selection	9236771
50359044	50359067	14	-	27260156	TOV112D	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	0.24005074001434085	[634]	[560,908,765,788]	4	hSpCas9	negative selection	9236772
50345032	50345055	14	+	27260156	TOV112D	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.9839547699862528	[246]	[83,147,98,169]	-9	hSpCas9	negative selection	9236773
50359116	50359139	14	-	27260156	TC71	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	0.23746184422329164	[1103]	[1322,1326,1279,1672]	6	hSpCas9	negative selection	9293744
50345025	50345048	14	-	27260156	TC71	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	-0.07001034490659297	[841]	[926,739,909,858]	-2	hSpCas9	negative selection	9293745
50338988	50339011	14	+	27260156	TC71	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.08437136451515798	[629]	[662,643,616,622]	-2	hSpCas9	negative selection	9293746
50338975	50338998	14	-	27260156	TC71	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	-0.10672409678889916	[156]	[103,190,141,191]	-3	hSpCas9	negative selection	9358022
50359044	50359067	14	-	27260156	TC71	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.02968792796516767	[634]	[568,694,647,763]	0	hSpCas9	negative selection	9358023
50345032	50345055	14	+	27260156	TC71	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.3369591000396621	[246]	[231,241,202,157]	-7	hSpCas9	negative selection	9358024
50359116	50359139	14	-	27260156	TC32	viability	TCCCAACCTTGTTAACCTCCTGG	CDKL1	ENSG00000100490	-0.00814366284374124	[1103]	[1023,729,1424,1071]	0	hSpCas9	negative selection	9414995
50345025	50345048	14	-	27260156	TC32	viability	ATCTCGTGAAGAGCATAACTTGG	CDKL1	ENSG00000100490	0.09493547038404027	[841]	[797,636,992,1021]	1	hSpCas9	negative selection	9414996
50338988	50339011	14	+	27260156	TC32	viability	GATTCGTGCTAAACACTTGCTGG	CDKL1	ENSG00000100490	-0.37231328201647895	[629]	[489,219,769,464]	-6	hSpCas9	negative selection	9414997
50338975	50338998	14	-	27260156	TC32	viability	AGCACGAATCAGTACTTCAGTGG	CDKL1	ENSG00000100490	-0.15433449927743537	[156]	[121,120,166,122]	-3	hSpCas9	negative selection	9479273
50359044	50359067	14	-	27260156	TC32	viability	CCACACAGTTCTCCATGAGTTGG	CDKL1	ENSG00000100490	-0.1393174493107846	[634]	[529,352,651,701]	-2	hSpCas9	negative selection	9479274
50345032	50345055	14	+	27260156	TC32	viability	ATGCTCTTCACGAGATGTTCTGG	CDKL1	ENSG00000100490	-0.5950230542202244	[246]	[108,84,244,218]	-8	hSpCas9	negative selection	9479275
50341121	50341144	14	+	27869803	HPAFII	viability after 27 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	0.3546907859551224	[237]	[153,164,NaN]	3	hSpCas9	negative selection	9551661
50341124	50341147	14	+	27869803	HPAFII	viability after 27 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-1.2376046822991538	[220]	[33,61,NaN]	-7	hSpCas9	negative selection	9551662
50359101	50359124	14	+	27869803	HPAFII	viability after 27 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-0.7056536359919926	[162]	[81,27,NaN]	-5	hSpCas9	negative selection	9551663
50359102	50359125	14	-	27869803	HPAFII	viability after 27 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-1.1977825065020196	[141]	[13,47,NaN]	-7	hSpCas9	negative selection	9551664
50395703	50395726	14	+	27869803	HPAFII	viability after 27 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.21694349705200366	[205]	[150,44,NaN]	-2	hSpCas9	negative selection	9551665
50395704	50395727	14	+	27869803	HPAFII	viability after 27 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.5543444875872156	[133]	[37,157,NaN]	4	hSpCas9	negative selection	9551666
50341121	50341144	14	+	27869803	HPAFII	viability after 15 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	0.7836158232072543	[237]	[472,419,NaN]	8	hSpCas9	negative selection	9634110
50341124	50341147	14	+	27869803	HPAFII	viability after 15 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-1.4312870844116783	[220]	[129,61,NaN]	-8	hSpCas9	negative selection	9634111
50359101	50359124	14	+	27869803	HPAFII	viability after 15 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-0.8042400439218801	[162]	[132,79,NaN]	-7	hSpCas9	negative selection	9634112
50359102	50359125	14	-	27869803	HPAFII	viability after 15 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-1.3875019230836982	[141]	[45,65,NaN]	-8	hSpCas9	negative selection	9634113
50395703	50395726	14	+	27869803	HPAFII	viability after 15 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.6244606279171878	[205]	[611,172,NaN]	7	hSpCas9	negative selection	9634114
50395704	50395727	14	+	27869803	HPAFII	viability after 15 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.29631749330535273	[133]	[174,177,NaN]	3	hSpCas9	negative selection	9634115
50341121	50341144	14	+	27869803	ASPC1	viability after 36 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-0.9650669582975085	[720]	[139,105,137]	-7	hSpCas9	negative selection	9716559
50341124	50341147	14	+	27869803	ASPC1	viability after 36 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-0.5721115929952685	[537]	[103,140,128]	-5	hSpCas9	negative selection	9716560
50359101	50359124	14	+	27869803	ASPC1	viability after 36 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-2.66595062213362	[364]	[37,27,0]	-9	hSpCas9	negative selection	9716561
50359102	50359125	14	-	27869803	ASPC1	viability after 36 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	1.0330200472330937	[216]	[207,56,193]	8	hSpCas9	negative selection	9716562
50395703	50395726	14	+	27869803	ASPC1	viability after 36 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.18140473033744792	[652]	[269,179,309]	1	hSpCas9	negative selection	9716563
50395704	50395727	14	+	27869803	ASPC1	viability after 36 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.18226619509891928	[349]	[142,90,94]	-2	hSpCas9	negative selection	9716564
50341121	50341144	14	+	27869803	PATU8988S	viability after 35 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-0.5352113273623642	[551]	[114,191,NaN]	-5	hSpCas9	negative selection	9799008
50341124	50341147	14	+	27869803	PATU8988S	viability after 35 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-0.4133519097268582	[379]	[78,150,NaN]	-4	hSpCas9	negative selection	9799009
50359101	50359124	14	+	27869803	PATU8988S	viability after 35 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	0.14699459481569177	[332]	[148,147,NaN]	1	hSpCas9	negative selection	9799010
50359102	50359125	14	-	27869803	PATU8988S	viability after 35 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-0.13539628393623615	[224]	[82,81,NaN]	-1	hSpCas9	negative selection	9799011
50395703	50395726	14	+	27869803	PATU8988S	viability after 35 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.20691624401633624	[524]	[266,220,NaN]	2	hSpCas9	negative selection	9799012
50395704	50395727	14	+	27869803	PATU8988S	viability after 35 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.5900097794597714	[423]	[89,136,NaN]	-5	hSpCas9	negative selection	9799013
50341121	50341144	14	+	27869803	PATU8988S	viability after 31 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-0.406781365362306	[551]	[103,244,NaN]	-4	hSpCas9	negative selection	9881457
50341124	50341147	14	+	27869803	PATU8988S	viability after 31 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-0.6434418491361995	[379]	[107,82,NaN]	-6	hSpCas9	negative selection	9881458
50359101	50359124	14	+	27869803	PATU8988S	viability after 31 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-0.5149840687124241	[332]	[95,88,NaN]	-5	hSpCas9	negative selection	9881459
50359102	50359125	14	-	27869803	PATU8988S	viability after 31 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-0.06379070915046192	[224]	[69,105,NaN]	0	hSpCas9	negative selection	9881460
50395703	50395726	14	+	27869803	PATU8988S	viability after 31 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.085580321128153	[524]	[213,175,NaN]	-1	hSpCas9	negative selection	9881461
50395704	50395727	14	+	27869803	PATU8988S	viability after 31 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	-0.6428749959728801	[423]	[91,128,NaN]	-6	hSpCas9	negative selection	9881462
50341121	50341144	14	+	27869803	HPAFII	viability after 35 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-0.16907886352158438	[237]	[77,139,NaN]	-1	hSpCas9	negative selection	9963906
50341124	50341147	14	+	27869803	HPAFII	viability after 35 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-4.2208515056736005	[220]	[5,5,NaN]	-9	hSpCas9	negative selection	9963907
50359101	50359124	14	+	27869803	HPAFII	viability after 35 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-1.8537781490415415	[162]	[35,7,NaN]	-7	hSpCas9	negative selection	9963908
50359102	50359125	14	-	27869803	HPAFII	viability after 35 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-1.4098173150570554	[141]	[19,34,NaN]	-6	hSpCas9	negative selection	9963909
50395703	50395726	14	+	27869803	HPAFII	viability after 35 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.23735421160680714	[205]	[79,97,NaN]	-1	hSpCas9	negative selection	9963910
50395704	50395727	14	+	27869803	HPAFII	viability after 35 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.4146791042918638	[133]	[1,189,NaN]	2	hSpCas9	negative selection	9963911
50341121	50341144	14	+	27869803	HPAFII	viability after 31 days	CCAATTGCCCAAACATCCACCGG	CDKL1	ENSG00000100490	-0.04408135833995379	[237]	[152,103,NaN]	0	hSpCas9	negative selection	10046355
50341124	50341147	14	+	27869803	HPAFII	viability after 31 days	ATTGCCCAAACATCCACCGGGGG	CDKL1	ENSG00000100490	-2.7943718009728085	[220]	[3,32,NaN]	-8	hSpCas9	negative selection	10046356
50359101	50359124	14	+	27869803	HPAFII	viability after 31 days	TCCTCCTGAAGACTTCCAGGAGG	CDKL1	ENSG00000100490	-1.7265221204690135	[162]	[41,11,NaN]	-7	hSpCas9	negative selection	10046357
50359102	50359125	14	-	27869803	HPAFII	viability after 31 days	ACCTCCTGGAAGTCTTCAGGAGG	CDKL1	ENSG00000100490	-1.7029284602552166	[141]	[23,24,NaN]	-7	hSpCas9	negative selection	10046358
50395703	50395726	14	+	27869803	HPAFII	viability after 31 days	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.10015254305171767	[205]	[110,137,NaN]	0	hSpCas9	negative selection	10046359
50395704	50395727	14	+	27869803	HPAFII	viability after 31 days	GAGCATTCGGATTTCCCGAAGGG	CDKL1	ENSG00000100490	0.27575593768466256	[133]	[24,162,NaN]	2	hSpCas9	negative selection	10046360
50359093	50359116	14	-	28162770	P31FUJ	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	0.43071694506957386	[136]	[216]	5	hSpCas9	negative selection	10130820
50341164	50341187	14	-	28162770	P31FUJ	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	0.43257897876207535	[156]	[248]	5	hSpCas9	negative selection	10130821
50359028	50359051	14	-	28162770	P31FUJ	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	0.36443862608521416	[116]	[176]	4	hSpCas9	negative selection	10130822
50341123	50341146	14	+	28162770	P31FUJ	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	-0.05862772997070831	[451]	[509]	0	hSpCas9	negative selection	10130823
50341189	50341212	14	-	28162770	P31FUJ	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	-0.5223088216093634	[54]	[44]	-4	hSpCas9	negative selection	10130824
50332264	50332287	14	+	28162770	P31FUJ	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	0.41927449216531465	[335]	[527]	5	hSpCas9	negative selection	10130825
50395703	50395726	14	+	28162770	P31FUJ	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.3436303346267583	[283]	[262]	-3	hSpCas9	negative selection	10130826
50341062	50341085	14	-	28162770	P31FUJ	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	0.48879498832862356	[603]	[995]	5	hSpCas9	negative selection	10130827
50341032	50341055	14	-	28162770	P31FUJ	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	-0.11630721267294519	[653]	[708]	-1	hSpCas9	negative selection	10130828
50395790	50395813	14	-	28162770	P31FUJ	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	0.552184904614771	[194]	[335]	6	hSpCas9	negative selection	10130829
50359093	50359116	14	-	28162770	TF1	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	NaN	[NaN]	[76]	1	hSpCas9	negative selection	10300186
50341164	50341187	14	-	28162770	TF1	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	NaN	[NaN]	[150]	1	hSpCas9	negative selection	10300187
50359028	50359051	14	-	28162770	TF1	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	NaN	[NaN]	[229]	1	hSpCas9	negative selection	10300188
50341123	50341146	14	+	28162770	TF1	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	NaN	[NaN]	[514]	1	hSpCas9	negative selection	10300189
50341189	50341212	14	-	28162770	TF1	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	NaN	[NaN]	[151]	1	hSpCas9	negative selection	10300190
50332264	50332287	14	+	28162770	TF1	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	NaN	[NaN]	[328]	1	hSpCas9	negative selection	10300191
50395703	50395726	14	+	28162770	TF1	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	NaN	[NaN]	[172]	1	hSpCas9	negative selection	10300192
50341062	50341085	14	-	28162770	TF1	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	NaN	[NaN]	[301]	1	hSpCas9	negative selection	10300193
50341032	50341055	14	-	28162770	TF1	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	NaN	[NaN]	[771]	1	hSpCas9	negative selection	10300194
50395790	50395813	14	-	28162770	TF1	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	NaN	[NaN]	[365]	1	hSpCas9	negative selection	10300195
50359093	50359116	14	-	28162770	SKM1	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	-0.47150445093787235	[39]	[50]	-4	hSpCas9	negative selection	10469552
50341164	50341187	14	-	28162770	SKM1	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	-0.9330330104107494	[26]	[24]	-6	hSpCas9	negative selection	10469553
50359028	50359051	14	-	28162770	SKM1	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	0.4082959213997885	[51]	[121]	4	hSpCas9	negative selection	10469554
50341123	50341146	14	+	28162770	SKM1	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	1.199478029388446	[99]	[405]	9	hSpCas9	negative selection	10469555
50341189	50341212	14	-	28162770	SKM1	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	0.244087492435767	[31]	[66]	2	hSpCas9	negative selection	10469556
50332264	50332287	14	+	28162770	SKM1	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	0.707889420205475	[88]	[256]	6	hSpCas9	negative selection	10469557
50395703	50395726	14	+	28162770	SKM1	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.8618141896254361	[46]	[150]	7	hSpCas9	negative selection	10469558
50341062	50341085	14	-	28162770	SKM1	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	0.5087773144476226	[129]	[326]	5	hSpCas9	negative selection	10469559
50341032	50341055	14	-	28162770	SKM1	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	1.0198890507828784	[170]	[612]	8	hSpCas9	negative selection	10469560
50395790	50395813	14	-	28162770	SKM1	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	0.8575976768372259	[58]	[188]	7	hSpCas9	negative selection	10469561
50359093	50359116	14	-	28162770	SKM1	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	-0.47150445093787235	[39]	[50]	-4	hSpCas9	negative selection	10638918
50341164	50341187	14	-	28162770	SKM1	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	-0.9330330104107494	[26]	[24]	-6	hSpCas9	negative selection	10638919
50359028	50359051	14	-	28162770	SKM1	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	0.4082959213997885	[51]	[121]	4	hSpCas9	negative selection	10638920
50341123	50341146	14	+	28162770	SKM1	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	1.199478029388446	[99]	[405]	9	hSpCas9	negative selection	10638921
50341189	50341212	14	-	28162770	SKM1	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	0.244087492435767	[31]	[66]	2	hSpCas9	negative selection	10638922
50332264	50332287	14	+	28162770	SKM1	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	0.707889420205475	[88]	[256]	6	hSpCas9	negative selection	10638923
50395703	50395726	14	+	28162770	SKM1	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.8618141896254361	[46]	[150]	7	hSpCas9	negative selection	10638924
50341062	50341085	14	-	28162770	SKM1	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	0.5087773144476226	[129]	[326]	5	hSpCas9	negative selection	10638925
50341032	50341055	14	-	28162770	SKM1	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	1.0198890507828784	[170]	[612]	8	hSpCas9	negative selection	10638926
50395790	50395813	14	-	28162770	SKM1	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	0.8575976768372259	[58]	[188]	7	hSpCas9	negative selection	10638927
50359093	50359116	14	-	28162770	PL21	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	1.8897994938771696	[123]	[199]	9	hSpCas9	negative selection	10808284
50341164	50341187	14	-	28162770	PL21	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	-0.44755864157979874	[93]	[29]	-3	hSpCas9	negative selection	10808285
50359028	50359051	14	-	28162770	PL21	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	-0.04174898247292491	[148]	[62]	0	hSpCas9	negative selection	10808286
50341123	50341146	14	+	28162770	PL21	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.12106804349812128	[449]	[212]	1	hSpCas9	negative selection	10808287
50341189	50341212	14	-	28162770	PL21	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	0.030214613047007566	[71]	[31]	0	hSpCas9	negative selection	10808288
50332264	50332287	14	+	28162770	PL21	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	-0.2469082796921448	[318]	[116]	-2	hSpCas9	negative selection	10808289
50395703	50395726	14	+	28162770	PL21	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.5605418571913183	[147]	[94]	5	hSpCas9	negative selection	10808290
50341062	50341085	14	-	28162770	PL21	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	-0.20147736902720204	[427]	[161]	-1	hSpCas9	negative selection	10808291
50341032	50341055	14	-	28162770	PL21	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	-0.11738778036899666	[490]	[196]	-1	hSpCas9	negative selection	10808292
50395790	50395813	14	-	28162770	PL21	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	0.31178497031822927	[173]	[93]	2	hSpCas9	negative selection	10808293
50359093	50359116	14	-	28162770	P31FUJ	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	0.43071694506957386	[136]	[216]	5	hSpCas9	negative selection	10977650
50341164	50341187	14	-	28162770	P31FUJ	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	0.43257897876207535	[156]	[248]	5	hSpCas9	negative selection	10977651
50359028	50359051	14	-	28162770	P31FUJ	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	0.36443862608521416	[116]	[176]	4	hSpCas9	negative selection	10977652
50341123	50341146	14	+	28162770	P31FUJ	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	-0.05862772997070831	[451]	[509]	0	hSpCas9	negative selection	10977653
50341189	50341212	14	-	28162770	P31FUJ	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	-0.5223088216093634	[54]	[44]	-4	hSpCas9	negative selection	10977654
50332264	50332287	14	+	28162770	P31FUJ	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	0.41927449216531465	[335]	[527]	5	hSpCas9	negative selection	10977655
50395703	50395726	14	+	28162770	P31FUJ	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.3436303346267583	[283]	[262]	-3	hSpCas9	negative selection	10977656
50341062	50341085	14	-	28162770	P31FUJ	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	0.48879498832862356	[603]	[995]	5	hSpCas9	negative selection	10977657
50341032	50341055	14	-	28162770	P31FUJ	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	-0.11630721267294519	[653]	[708]	-1	hSpCas9	negative selection	10977658
50395790	50395813	14	-	28162770	P31FUJ	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	0.552184904614771	[194]	[335]	6	hSpCas9	negative selection	10977659
50359093	50359116	14	-	28162770	OCIAML5	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	-0.21683086366161713	[93]	[145]	-1	hSpCas9	negative selection	11147016
50341164	50341187	14	-	28162770	OCIAML5	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	0.6613426688321251	[61]	[176]	6	hSpCas9	negative selection	11147017
50359028	50359051	14	-	28162770	OCIAML5	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	0.41739410412922995	[55]	[134]	3	hSpCas9	negative selection	11147018
50341123	50341146	14	+	28162770	OCIAML5	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.3841846990328385	[221]	[522]	3	hSpCas9	negative selection	11147019
50341189	50341212	14	-	28162770	OCIAML5	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	-0.044711648806393	[11]	[20]	0	hSpCas9	negative selection	11147020
50332264	50332287	14	+	28162770	OCIAML5	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	0.18866368155475	[226]	[466]	1	hSpCas9	negative selection	11147021
50395703	50395726	14	+	28162770	OCIAML5	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.03454462264939406	[201]	[355]	0	hSpCas9	negative selection	11147022
50341062	50341085	14	-	28162770	OCIAML5	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	0.02621752073631023	[308]	[567]	0	hSpCas9	negative selection	11147023
50341032	50341055	14	-	28162770	OCIAML5	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	0.42952942998814714	[398]	[969]	3	hSpCas9	negative selection	11147024
50395790	50395813	14	-	28162770	OCIAML5	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	0.9469086855776339	[147]	[514]	7	hSpCas9	negative selection	11147025
50359093	50359116	14	-	28162770	EOL1	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	-0.9048334568170685	[230]	[64]	-6	hSpCas9	negative selection	11316382
50341164	50341187	14	-	28162770	EOL1	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	0.04319226806915344	[104]	[56]	0	hSpCas9	negative selection	11316383
50359028	50359051	14	-	28162770	EOL1	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	0.13291330763469714	[250]	[144]	1	hSpCas9	negative selection	11316384
50341123	50341146	14	+	28162770	EOL1	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.5863441369703417	[779]	[616]	5	hSpCas9	negative selection	11316385
50341189	50341212	14	-	28162770	EOL1	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	0.9008965035058891	[122]	[120]	7	hSpCas9	negative selection	11316386
50332264	50332287	14	+	28162770	EOL1	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	-0.07545222842946542	[539]	[269]	0	hSpCas9	negative selection	11316387
50395703	50395726	14	+	28162770	EOL1	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.11320715042488341	[270]	[131]	-1	hSpCas9	negative selection	11316388
50341062	50341085	14	-	28162770	EOL1	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	1.4896654608948197	[487]	[721]	9	hSpCas9	negative selection	11316389
50341032	50341055	14	-	28162770	EOL1	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	0.16620852661176144	[679]	[401]	1	hSpCas9	negative selection	11316390
50395790	50395813	14	-	28162770	EOL1	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	-0.2421020978389169	[219]	[97]	-2	hSpCas9	negative selection	11316391
50359093	50359116	14	-	28162770	MOLM13	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	0.3921620553813339	[175]	[166]	3	hSpCas9	negative selection	11485748
50341164	50341187	14	-	28162770	MOLM13	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	-1.6741296233278489	[127]	[28]	-7	hSpCas9	negative selection	11485749
50359028	50359051	14	-	28162770	MOLM13	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	2.1497796260036113	[282]	[907]	9	hSpCas9	negative selection	11485750
50341123	50341146	14	+	28162770	MOLM13	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	1.0934938667630811	[594]	[917]	8	hSpCas9	negative selection	11485751
50341189	50341212	14	-	28162770	MOLM13	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	-0.6357332495295789	[100]	[46]	-4	hSpCas9	negative selection	11485752
50332264	50332287	14	+	28162770	MOLM13	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	1.555131778904064	[384]	[817]	9	hSpCas9	negative selection	11485753
50395703	50395726	14	+	28162770	MOLM13	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.577198507983959	[259]	[125]	-3	hSpCas9	negative selection	11485754
50341062	50341085	14	-	28162770	MOLM13	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	0.7966711474730036	[503]	[632]	6	hSpCas9	negative selection	11485755
50341032	50341055	14	-	28162770	MOLM13	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	0.027062009576762636	[808]	[595]	0	hSpCas9	negative selection	11485756
50395790	50395813	14	-	28162770	MOLM13	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	-0.062001736682901626	[256]	[177]	0	hSpCas9	negative selection	11485757
50359093	50359116	14	-	28162770	HEL	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	1.0518514973220952	[182]	[242]	8	hSpCas9	negative selection	11655114
50341164	50341187	14	-	28162770	HEL	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	-0.8104337961652579	[114]	[41]	-5	hSpCas9	negative selection	11655115
50359028	50359051	14	-	28162770	HEL	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	0.24999999983028737	[213]	[162]	2	hSpCas9	negative selection	11655116
50341123	50341146	14	+	28162770	HEL	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.43252112461001135	[589]	[509]	3	hSpCas9	negative selection	11655117
50341189	50341212	14	-	28162770	HEL	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	0.33398612586072784	[108]	[87]	2	hSpCas9	negative selection	11655118
50332264	50332287	14	+	28162770	HEL	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	0.9281410508626052	[415]	[506]	7	hSpCas9	negative selection	11655119
50395703	50395726	14	+	28162770	HEL	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.7672373741182426	[232]	[253]	6	hSpCas9	negative selection	11655120
50341062	50341085	14	-	28162770	HEL	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	0.07107315389265856	[485]	[326]	0	hSpCas9	negative selection	11655121
50341032	50341055	14	-	28162770	HEL	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	0.32315849196941726	[613]	[491]	2	hSpCas9	negative selection	11655122
50395790	50395813	14	-	28162770	HEL	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	0.5710373666461683	[164]	[156]	5	hSpCas9	negative selection	11655123
50359093	50359116	14	-	28162770	MV411	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	0.510471956616569	[129]	[155]	4	hSpCas9	negative selection	11824480
50341164	50341187	14	-	28162770	MV411	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	-0.08816548100166344	[52]	[41]	0	hSpCas9	negative selection	11824481
50359028	50359051	14	-	28162770	MV411	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	0.46156235613562263	[174]	[202]	4	hSpCas9	negative selection	11824482
50341123	50341146	14	+	28162770	MV411	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	-0.055954592667159186	[405]	[328]	0	hSpCas9	negative selection	11824483
50341189	50341212	14	-	28162770	MV411	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	0.49136313366886464	[37]	[44]	4	hSpCas9	negative selection	11824484
50332264	50332287	14	+	28162770	MV411	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	0.7025704556394176	[274]	[376]	6	hSpCas9	negative selection	11824485
50395703	50395726	14	+	28162770	MV411	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.14434405781867177	[173]	[161]	1	hSpCas9	negative selection	11824486
50341062	50341085	14	-	28162770	MV411	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	-0.4461752052256406	[447]	[276]	-3	hSpCas9	negative selection	11824487
50341032	50341055	14	-	28162770	MV411	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	0.4952282445533589	[554]	[658]	4	hSpCas9	negative selection	11824488
50395790	50395813	14	-	28162770	MV411	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	0.4369153496464881	[170]	[194]	4	hSpCas9	negative selection	11824489
50359093	50359116	14	-	28162770	MONOMAC1	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	-0.05118598059609908	[93]	[103]	0	hSpCas9	negative selection	11993846
50341164	50341187	14	-	28162770	MONOMAC1	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	0.05232262187716352	[52]	[62]	0	hSpCas9	negative selection	11993847
50359028	50359051	14	-	28162770	MONOMAC1	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	0.7784408338063771	[88]	[174]	7	hSpCas9	negative selection	11993848
50341123	50341146	14	+	28162770	MONOMAC1	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.9833885668645801	[288]	[654]	8	hSpCas9	negative selection	11993849
50341189	50341212	14	-	28162770	MONOMAC1	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	2.1113021830798533	[63]	[316]	9	hSpCas9	negative selection	11993850
50332264	50332287	14	+	28162770	MONOMAC1	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	0.0648298573419055	[205]	[246]	0	hSpCas9	negative selection	11993851
50395703	50395726	14	+	28162770	MONOMAC1	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-1.8381424258182437	[130]	[41]	-8	hSpCas9	negative selection	11993852
50341062	50341085	14	-	28162770	MONOMAC1	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	0.2839349224040666	[277]	[387]	3	hSpCas9	negative selection	11993853
50341032	50341055	14	-	28162770	MONOMAC1	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	0.9444246902590643	[363]	[802]	8	hSpCas9	negative selection	11993854
50395790	50395813	14	-	28162770	MONOMAC1	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	0.7090452895528074	[118]	[222]	6	hSpCas9	negative selection	11993855
50359093	50359116	14	-	28162770	OCIAML2	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	-0.020596904607113664	[27]	[152]	0	hSpCas9	negative selection	12163212
50341164	50341187	14	-	28162770	OCIAML2	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	-0.8591951131598139	[17]	[54]	-6	hSpCas9	negative selection	12163213
50359028	50359051	14	-	28162770	OCIAML2	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	-0.03891358481668716	[42]	[231]	0	hSpCas9	negative selection	12163214
50341123	50341146	14	+	28162770	OCIAML2	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.2405097815561399	[92]	[608]	2	hSpCas9	negative selection	12163215
50341189	50341212	14	-	28162770	OCIAML2	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	-0.0892007186061371	[18]	[98]	0	hSpCas9	negative selection	12163216
50332264	50332287	14	+	28162770	OCIAML2	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	0.3571891993751587	[59]	[425]	3	hSpCas9	negative selection	12163217
50395703	50395726	14	+	28162770	OCIAML2	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	-0.09866104785520335	[33]	[175]	-1	hSpCas9	negative selection	12163218
50341062	50341085	14	-	28162770	OCIAML2	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	-0.5683264991292943	[83]	[313]	-4	hSpCas9	negative selection	12163219
50341032	50341055	14	-	28162770	OCIAML2	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	0.5453117186268601	[89]	[727]	5	hSpCas9	negative selection	12163220
50395790	50395813	14	-	28162770	OCIAML2	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	1.114332675478995	[24]	[299]	9	hSpCas9	negative selection	12163221
50359093	50359116	14	-	28162770	OCIAML3	viability	AAGTCTTCAGGAGGAAACGGAGG	CDKL1	ENSG00000100490	0.12646983105347395	[43]	[144]	1	hSpCas9	negative selection	12332578
50341164	50341187	14	-	28162770	OCIAML3	viability	CCGCTCCCCTGAGCTGCTGGTGG	CDKL1	ENSG00000100490	1.3641721839812098	[34]	[271]	9	hSpCas9	negative selection	12332579
50359028	50359051	14	-	28162770	OCIAML3	viability	GAGTTGGACAGATACCAAAGAGG	CDKL1	ENSG00000100490	0.622803748748985	[36]	[171]	5	hSpCas9	negative selection	12332580
50341123	50341146	14	+	28162770	OCIAML3	viability	AATTGCCCAAACATCCACCGGGG	CDKL1	ENSG00000100490	0.13254133789670464	[138]	[459]	1	hSpCas9	negative selection	12332581
50341189	50341212	14	-	28162770	OCIAML3	viability	CAGACTACGTGGCTACCAGGTGG	CDKL1	ENSG00000100490	-1.009045139603007	[21]	[32]	-6	hSpCas9	negative selection	12332582
50332264	50332287	14	+	28162770	OCIAML3	viability	TGGATGTTTCTGTAAAGCAGTGG	CDKL1	ENSG00000100490	0.7147450658154659	[87]	[435]	6	hSpCas9	negative selection	12332583
50395703	50395726	14	+	28162770	OCIAML3	viability	TGAGCATTCGGATTTCCCGAAGG	CDKL1	ENSG00000100490	0.0009389489696150777	[47]	[144]	0	hSpCas9	negative selection	12332584
50341062	50341085	14	-	28162770	OCIAML3	viability	GTGGCCAGGAAAATCGGATGTGG	CDKL1	ENSG00000100490	-0.10944703656084487	[118]	[332]	-1	hSpCas9	negative selection	12332585
50341032	50341055	14	-	28162770	OCIAML3	viability	GTATCTGATTAGGAAGACCTTGG	CDKL1	ENSG00000100490	0.2133472817334412	[129]	[454]	2	hSpCas9	negative selection	12332586
50395790	50395813	14	-	28162770	OCIAML3	viability	CAAATGTAGAAACAGGGACACGG	CDKL1	ENSG00000100490	-0.08093805808479274	[47]	[136]	0	hSpCas9	negative selection	12332587