Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:1019
• Symbol:Cdk4
• Description:cyclin dependent kinase 4

DataSource: http://genomecrispr.dkfz.de/#!/results/Cdk4

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
57751632	57751655	12	-	26472758	Jiyoye	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	-3.259087221317131	[291]	[22]	-9	hSpCas9	negative selection	28794
57750937	57750960	12	-	26472758	Jiyoye	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	-5.658913808951899	[66]	[0]	-9	hSpCas9	negative selection	28795
57750922	57750945	12	-	26472758	Jiyoye	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-3.8407521319377125	[18]	[0]	-9	hSpCas9	negative selection	28796
57749217	57749240	12	+	26472758	Jiyoye	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	-2.714815142872737	[295]	[33]	-9	hSpCas9	negative selection	28797
57751618	57751641	12	+	26472758	Jiyoye	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	-1.0173224470220368	[50]	[18]	-6	hSpCas9	negative selection	28798
57751593	57751616	12	-	26472758	Jiyoye	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	-0.5928246184941264	[19]	[9]	-4	hSpCas9	negative selection	28799
57751581	57751604	12	-	26472758	Jiyoye	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	-0.13048140443692624	[44]	[30]	-1	hSpCas9	negative selection	28800
57751546	57751569	12	-	26472758	Jiyoye	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	-3.8760491840510047	[330]	[16]	-9	hSpCas9	negative selection	28801
57751242	57751265	12	-	26472758	Jiyoye	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	-2.831229357819206	[150]	[15]	-9	hSpCas9	negative selection	28802
57751214	57751237	12	+	26472758	Jiyoye	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	-2.3835966563561266	[172]	[24]	-8	hSpCas9	negative selection	28803
57751632	57751655	12	-	26472758	KBM7	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	-0.38291846346769454	[1111,815]	[431,264]	-4	hSpCas9	negative selection	219912
57750937	57750960	12	-	26472758	KBM7	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	-0.6017390840955725	[279,256]	[59,103]	-5	hSpCas9	negative selection	219913
57750922	57750945	12	-	26472758	KBM7	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.017559458230452463	[406,238]	[84,201]	0	hSpCas9	negative selection	219914
57749217	57749240	12	+	26472758	KBM7	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	-0.660930284653926	[1156,804]	[319,258]	-5	hSpCas9	negative selection	219915
57751618	57751641	12	+	26472758	KBM7	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	0.990776963195517	[105,95]	[115,74]	9	hSpCas9	negative selection	219916
57751593	57751616	12	-	26472758	KBM7	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	-0.01241532423000924	[425,192]	[121,154]	0	hSpCas9	negative selection	219917
57751581	57751604	12	-	26472758	KBM7	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	-0.8401272542670803	[327,224]	[50,89]	-6	hSpCas9	negative selection	219918
57751546	57751569	12	-	26472758	KBM7	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	-0.3402066112280602	[1626,1647]	[638,586]	-3	hSpCas9	negative selection	219919
57751242	57751265	12	-	26472758	KBM7	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	-0.7293587569404814	[807,695]	[246,181]	-6	hSpCas9	negative selection	219920
57751214	57751237	12	+	26472758	KBM7	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	0.07552531348721292	[856,589]	[363,343]	0	hSpCas9	negative selection	219921
57751632	57751655	12	-	26472758	Raji	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	-0.08054941521947567	[523]	[114]	0	hSpCas9	negative selection	411030
57750937	57750960	12	-	26472758	Raji	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	0.44687000164526636	[97]	[30]	4	hSpCas9	negative selection	411031
57750922	57750945	12	-	26472758	Raji	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	0.8675565207011309	[110]	[46]	7	hSpCas9	negative selection	411032
57749217	57749240	12	+	26472758	Raji	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	-0.40163011211425803	[443]	[77]	-3	hSpCas9	negative selection	411033
57751618	57751641	12	+	26472758	Raji	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	-0.3844695609560751	[44]	[7]	-3	hSpCas9	negative selection	411034
57751593	57751616	12	-	26472758	Raji	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	-0.5727361983878965	[140]	[21]	-4	hSpCas9	negative selection	411035
57751581	57751604	12	-	26472758	Raji	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	-1.5409049007163858	[162]	[12]	-8	hSpCas9	negative selection	411036
57751546	57751569	12	-	26472758	Raji	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	-0.5768405967206331	[751]	[116]	-4	hSpCas9	negative selection	411037
57751242	57751265	12	-	26472758	Raji	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	-0.6876141801640218	[464]	[66]	-5	hSpCas9	negative selection	411038
57751214	57751237	12	+	26472758	Raji	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	0.2793362181628944	[315]	[88]	2	hSpCas9	negative selection	411039
57751632	57751655	12	-	26472758	K562	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	-0.7354033903959226	[780]	[395]	-4	hSpCas9	negative selection	602148
57750937	57750960	12	-	26472758	K562	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	-0.30699121334368284	[254]	[173]	-2	hSpCas9	negative selection	602149
57750922	57750945	12	-	26472758	K562	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.012591890539576878	[238]	[199]	0	hSpCas9	negative selection	602150
57749217	57749240	12	+	26472758	K562	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	0.15281470692295218	[893]	[838]	1	hSpCas9	negative selection	602151
57751618	57751641	12	+	26472758	K562	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	2.072652379399967	[48]	[173]	9	hSpCas9	negative selection	602152
57751593	57751616	12	-	26472758	K562	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	-0.31576067212482106	[201]	[136]	-2	hSpCas9	negative selection	602153
57751581	57751604	12	-	26472758	K562	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	0.5315168383907102	[217]	[265]	4	hSpCas9	negative selection	602154
57751546	57751569	12	-	26472758	K562	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	0.1573176726709533	[1245]	[1172]	1	hSpCas9	negative selection	602155
57751242	57751265	12	-	26472758	K562	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	0.6806415568359186	[506]	[685]	5	hSpCas9	negative selection	602156
57751214	57751237	12	+	26472758	K562	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	-1.2326988178390925	[553]	[198]	-6	hSpCas9	negative selection	602157
57748558	57748581	12	+	26627737	DLD1	viability	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	0.10506629838125393	[427]	[183,102,142]	1	hSpCas9	negative selection	784977
57749218	57749241	12	+	26627737	DLD1	viability	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-1.7501623398358919	[813]	[51,76,94]	-8	hSpCas9	negative selection	784978
57750686	57750709	12	+	26627737	DLD1	viability	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	0.10346003538660853	[885]	[380,327,199]	1	hSpCas9	negative selection	784979
57750922	57750945	12	-	26627737	DLD1	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	2.1934236176155792	[3546]	[810,1291,11892]	9	hSpCas9	negative selection	784980
57751202	57751225	12	+	26627737	DLD1	viability	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	0.9364551945592812	[698]	[445,538,293]	8	hSpCas9	negative selection	784981
57751528	57751551	12	-	26627737	DLD1	viability	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-0.23488068519201644	[51]	[8,14,16]	-2	hSpCas9	negative selection	784982
57748558	57748581	12	+	26627737	GBM cells	viability after 5 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-0.7640511378367435	[246]	[80,74]	-8	hSpCas9	negative selection	867292
57749218	57749241	12	+	26627737	GBM cells	viability after 5 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-0.5884378292090483	[299]	[62,150]	-7	hSpCas9	negative selection	867293
57750686	57750709	12	+	26627737	GBM cells	viability after 5 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-1.1308334685083665	[342]	[78,88]	-9	hSpCas9	negative selection	867294
57750922	57750945	12	-	26627737	GBM cells	viability after 5 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-1.1347797406086158	[1082]	[269,258]	-9	hSpCas9	negative selection	867295
57751202	57751225	12	+	26627737	GBM cells	viability after 5 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.42992258934385436	[313]	[121,127]	-6	hSpCas9	negative selection	867296
57751528	57751551	12	-	26627737	GBM cells	viability after 5 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-0.7266906103328163	[53]	[15,18]	-8	hSpCas9	negative selection	867297
57748558	57748581	12	+	26627737	GBM cells	viability after 13 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-1.4300660048465863	[246]	[73,29]	-9	hSpCas9	negative selection	949607
57749218	57749241	12	+	26627737	GBM cells	viability after 13 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-1.2946270557689792	[299]	[83,51]	-8	hSpCas9	negative selection	949608
57750686	57750709	12	+	26627737	GBM cells	viability after 13 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-1.2972078411662913	[342]	[83,68]	-8	hSpCas9	negative selection	949609
57750922	57750945	12	-	26627737	GBM cells	viability after 13 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-1.8270658626081198	[1082]	[217,122]	-9	hSpCas9	negative selection	949610
57751202	57751225	12	+	26627737	GBM cells	viability after 13 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.1788979485534776	[313]	[187,119]	-2	hSpCas9	negative selection	949611
57751528	57751551	12	-	26627737	GBM cells	viability after 13 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-0.21920164282552257	[53]	[17,30]	-3	hSpCas9	negative selection	949612
57748558	57748581	12	+	26627737	GBM cells	viability after 21 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-0.8748002317033466	[246]	[68,76]	-6	hSpCas9	negative selection	1031922
57749218	57749241	12	+	26627737	GBM cells	viability after 21 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-1.114859206790297	[299]	[80,69]	-7	hSpCas9	negative selection	1031923
57750686	57750709	12	+	26627737	GBM cells	viability after 21 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-0.8205803432449219	[342]	[116,94]	-6	hSpCas9	negative selection	1031924
57750922	57750945	12	-	26627737	GBM cells	viability after 21 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-2.1077096563584226	[1082]	[147,125]	-9	hSpCas9	negative selection	1031925
57751202	57751225	12	+	26627737	GBM cells	viability after 21 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-1.2382420099331157	[313]	[64,78]	-7	hSpCas9	negative selection	1031926
57751528	57751551	12	-	26627737	GBM cells	viability after 21 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-0.5559356641363378	[53]	[20,18]	-5	hSpCas9	negative selection	1031927
57748558	57748581	12	+	26627737	RPE1	viability after 9 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-5.6747381406569675	[1325]	[8,6]	-9	hSpCas9	negative selection	1114237
57749218	57749241	12	+	26627737	RPE1	viability after 9 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-1.2784056739002123	[678]	[91,81]	-7	hSpCas9	negative selection	1114238
57750686	57750709	12	+	26627737	RPE1	viability after 9 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-3.39177661819516	[1944]	[33,88]	-9	hSpCas9	negative selection	1114239
57750922	57750945	12	-	26627737	RPE1	viability after 9 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-2.9561954993487447	[3120]	[45,228]	-9	hSpCas9	negative selection	1114240
57751202	57751225	12	+	26627737	RPE1	viability after 9 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	0.04763963216300793	[386]	[174,60]	0	hSpCas9	negative selection	1114241
57751528	57751551	12	-	26627737	RPE1	viability after 9 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.6754465303148196	[1]	[0,0]	4	hSpCas9	negative selection	1114242
57748558	57748581	12	+	26627737	RPE1	viability after 12 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-5.213719242605656	[1325]	[12,5]	-9	hSpCas9	negative selection	1196552
57749218	57749241	12	+	26627737	RPE1	viability after 12 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-2.1861400758966614	[678]	[76,0]	-8	hSpCas9	negative selection	1196553
57750686	57750709	12	+	26627737	RPE1	viability after 12 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-5.042382083907914	[1944]	[10,20]	-9	hSpCas9	negative selection	1196554
57750922	57750945	12	-	26627737	RPE1	viability after 12 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-2.8120222038686298	[3120]	[132,104]	-9	hSpCas9	negative selection	1196555
57751202	57751225	12	+	26627737	RPE1	viability after 12 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.8599748400739562	[386]	[100,10]	-5	hSpCas9	negative selection	1196556
57751528	57751551	12	-	26627737	RPE1	viability after 12 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.8961114116731377	[1]	[0,0]	5	hSpCas9	negative selection	1196557
57748558	57748581	12	+	26627737	RPE1	viability after 15 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-3.876005332182432	[1325]	[50,0]	-9	hSpCas9	negative selection	1278867
57749218	57749241	12	+	26627737	RPE1	viability after 15 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-1.9674822564218717	[678]	[98,0]	-8	hSpCas9	negative selection	1278868
57750686	57750709	12	+	26627737	RPE1	viability after 15 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-9.103805566001661	[1944]	[0,0]	-9	hSpCas9	negative selection	1278869
57750922	57750945	12	-	26627737	RPE1	viability after 15 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-2.9976391397310715	[3120]	[23,193]	-9	hSpCas9	negative selection	1278870
57751202	57751225	12	+	26627737	RPE1	viability after 15 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	0.01885714026100993	[386]	[171,51]	0	hSpCas9	negative selection	1278871
57751528	57751551	12	-	26627737	RPE1	viability after 15 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.8217488738718943	[1]	[0,0]	5	hSpCas9	negative selection	1278872
57748558	57748581	12	+	26627737	RPE1	viability after 18 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-5.356455633088317	[1325]	[0,16]	-9	hSpCas9	negative selection	1361182
57749218	57749241	12	+	26627737	RPE1	viability after 18 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-1.6648148621947056	[678]	[109,1]	-7	hSpCas9	negative selection	1361183
57750686	57750709	12	+	26627737	RPE1	viability after 18 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-8.466966521547379	[1944]	[0,1]	-9	hSpCas9	negative selection	1361184
57750922	57750945	12	-	26627737	RPE1	viability after 18 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-2.745083366449222	[3120]	[41,214]	-9	hSpCas9	negative selection	1361185
57751202	57751225	12	+	26627737	RPE1	viability after 18 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.7876017522950678	[386]	[45,75]	-5	hSpCas9	negative selection	1361186
57751528	57751551	12	-	26627737	RPE1	viability after 18 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.8896682601007431	[1]	[0,0]	5	hSpCas9	negative selection	1361187
57748558	57748581	12	+	26627737	HeLa	viability after 8 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-0.8950336570784624	[526]	[136,68,163]	-7	hSpCas9	negative selection	1443497
57749218	57749241	12	+	26627737	HeLa	viability after 8 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	0.440914303492945	[518]	[335,295,294]	4	hSpCas9	negative selection	1443498
57750686	57750709	12	+	26627737	HeLa	viability after 8 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	0.11360450098846109	[662]	[228,508,188]	1	hSpCas9	negative selection	1443499
57750922	57750945	12	-	26627737	HeLa	viability after 8 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.4989931634374243	[1964]	[905,498,484]	-5	hSpCas9	negative selection	1443500
57751202	57751225	12	+	26627737	HeLa	viability after 8 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	0.6911820892785053	[377]	[393,224,209]	6	hSpCas9	negative selection	1443501
57751528	57751551	12	-	26627737	HeLa	viability after 8 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	1.2202161831093263	[110]	[112,175,52]	8	hSpCas9	negative selection	1443502
57748558	57748581	12	+	26627737	HeLa	viability after 12 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	0.09011692330990068	[526]	[327,158,218]	0	hSpCas9	negative selection	1525812
57749218	57749241	12	+	26627737	HeLa	viability after 12 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-1.3179517397538119	[518]	[56,144,48]	-8	hSpCas9	negative selection	1525813
57750686	57750709	12	+	26627737	HeLa	viability after 12 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	0.2849289158695556	[662]	[540,328,137]	2	hSpCas9	negative selection	1525814
57750922	57750945	12	-	26627737	HeLa	viability after 12 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	0.049867729263767036	[1964]	[1225,680,642]	0	hSpCas9	negative selection	1525815
57751202	57751225	12	+	26627737	HeLa	viability after 12 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	0.2384936884547107	[377]	[159,185,205]	2	hSpCas9	negative selection	1525816
57751528	57751551	12	-	26627737	HeLa	viability after 12 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.20413511583462984	[110]	[47,65,42]	1	hSpCas9	negative selection	1525817
57748558	57748581	12	+	26627737	HeLa	viability after 15 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	0.16660309630780762	[526]	[319,261,130]	1	hSpCas9	negative selection	1608127
57749218	57749241	12	+	26627737	HeLa	viability after 15 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-0.5551176529226609	[518]	[273,68,81]	-5	hSpCas9	negative selection	1608128
57750686	57750709	12	+	26627737	HeLa	viability after 15 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	0.13328077759675738	[662]	[400,246,233]	1	hSpCas9	negative selection	1608129
57750922	57750945	12	-	26627737	HeLa	viability after 15 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.3806708192105659	[1964]	[570,704,563]	-3	hSpCas9	negative selection	1608130
57751202	57751225	12	+	26627737	HeLa	viability after 15 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	0.13870347296137028	[377]	[126,233,145]	1	hSpCas9	negative selection	1608131
57751528	57751551	12	-	26627737	HeLa	viability after 15 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.6861859939009596	[110]	[56,152,2]	5	hSpCas9	negative selection	1608132
57748558	57748581	12	+	26627737	HeLa	viability after 18 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	0.16948367588018037	[526]	[209,223,130]	1	hSpCas9	negative selection	1690442
57749218	57749241	12	+	26627737	HeLa	viability after 18 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-0.5808882392138991	[518]	[182,51,81]	-5	hSpCas9	negative selection	1690443
57750686	57750709	12	+	26627737	HeLa	viability after 18 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	0.12807037435540336	[662]	[260,211,233]	1	hSpCas9	negative selection	1690444
57750922	57750945	12	-	26627737	HeLa	viability after 18 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.3849369524961228	[1964]	[392,566,563]	-3	hSpCas9	negative selection	1690445
57751202	57751225	12	+	26627737	HeLa	viability after 18 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	0.14647841425797098	[377]	[81,199,145]	1	hSpCas9	negative selection	1690446
57751528	57751551	12	-	26627737	HeLa	viability after 18 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.6615410816805083	[110]	[37,123,2]	5	hSpCas9	negative selection	1690447
57748558	57748581	12	+	26627737	HCT116	viability after 6 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-0.06231368531173803	[634]	[54,117]	0	hSpCas9	negative selection	1772757
57749218	57749241	12	+	26627737	HCT116	viability after 6 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-1.0984076800150806	[790]	[137,13]	-6	hSpCas9	negative selection	1772758
57750686	57750709	12	+	26627737	HCT116	viability after 6 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	0.40946976196544665	[802]	[429,22]	2	hSpCas9	negative selection	1772759
57750922	57750945	12	-	26627737	HCT116	viability after 6 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	0.7676393203722298	[2350]	[868,496]	4	hSpCas9	negative selection	1772760
57751202	57751225	12	+	26627737	HCT116	viability after 6 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	0.5368352168935614	[832]	[276,141]	3	hSpCas9	negative selection	1772761
57751528	57751551	12	-	26627737	HCT116	viability after 6 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-2.2125511461567253	[299]	[24,1]	-8	hSpCas9	negative selection	1772762
57748558	57748581	12	+	26627737	HCT116	viability after 8 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-0.6589154486984388	[466]	[179,125,182]	-7	hSpCas9	negative selection	1855072
57749218	57749241	12	+	26627737	HCT116	viability after 8 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-0.8032423053044992	[416]	[121,152,119]	-7	hSpCas9	negative selection	1855073
57750686	57750709	12	+	26627737	HCT116	viability after 8 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-0.7654377972777917	[600]	[258,164,161]	-7	hSpCas9	negative selection	1855074
57750922	57750945	12	-	26627737	HCT116	viability after 8 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.7829972515913635	[1498]	[463,511,463]	-7	hSpCas9	negative selection	1855075
57751202	57751225	12	+	26627737	HCT116	viability after 8 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	1.1211741280394034	[125]	[143,161,146]	8	hSpCas9	negative selection	1855076
57751528	57751551	12	-	26627737	HCT116	viability after 8 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.986811576652503	[30]	[12,38,48]	8	hSpCas9	negative selection	1855077
57748558	57748581	12	+	26627737	HCT116	viability after 9 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-2.3498519990103914	[634]	[25,38]	-9	hSpCas9	negative selection	1937387
57749218	57749241	12	+	26627737	HCT116	viability after 9 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-0.6188309627710746	[790]	[160,118]	-4	hSpCas9	negative selection	1937388
57750686	57750709	12	+	26627737	HCT116	viability after 9 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	0.2770012599452106	[802]	[337,197]	2	hSpCas9	negative selection	1937389
57750922	57750945	12	-	26627737	HCT116	viability after 9 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	0.04525940160541997	[2350]	[959,400]	0	hSpCas9	negative selection	1937390
57751202	57751225	12	+	26627737	HCT116	viability after 9 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	0.3571791189942122	[832]	[342,238]	2	hSpCas9	negative selection	1937391
57751528	57751551	12	-	26627737	HCT116	viability after 9 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-2.331158420940901	[299]	[30,3]	-9	hSpCas9	negative selection	1937392
57748558	57748581	12	+	26627737	HCT116	viability after 12 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-0.5427322201841134	[466]	[158,157,188]	-5	hSpCas9	negative selection	2019702
57749218	57749241	12	+	26627737	HCT116	viability after 12 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-0.8492565323021788	[416]	[67,177,124]	-7	hSpCas9	negative selection	2019703
57750686	57750709	12	+	26627737	HCT116	viability after 12 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-1.1760291328110433	[600]	[77,107,237]	-8	hSpCas9	negative selection	2019704
57750922	57750945	12	-	26627737	HCT116	viability after 12 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.6239491308855014	[1498]	[670,449,396]	-6	hSpCas9	negative selection	2019705
57751202	57751225	12	+	26627737	HCT116	viability after 12 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	1.4755586746897165	[125]	[229,208,109]	9	hSpCas9	negative selection	2019706
57751528	57751551	12	-	26627737	HCT116	viability after 12 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	1.4195982367611844	[30]	[9,14,107]	9	hSpCas9	negative selection	2019707
57748558	57748581	12	+	26627737	HCT116	viability after 15 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-0.5749095587442634	[466]	[142,159,231]	-5	hSpCas9	negative selection	2102017
57749218	57749241	12	+	26627737	HCT116	viability after 15 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	0.00697875464540515	[416]	[154,107,445]	0	hSpCas9	negative selection	2102018
57750686	57750709	12	+	26627737	HCT116	viability after 15 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-0.6039006968263441	[600]	[117,237,310]	-6	hSpCas9	negative selection	2102019
57750922	57750945	12	-	26627737	HCT116	viability after 15 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.7955577574487533	[1498]	[842,346,341]	-7	hSpCas9	negative selection	2102020
57751202	57751225	12	+	26627737	HCT116	viability after 15 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	1.6103044405994165	[125]	[290,215,164]	9	hSpCas9	negative selection	2102021
57751528	57751551	12	-	26627737	HCT116	viability after 15 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-1.0017975619561046	[30]	[10,12,2]	-7	hSpCas9	negative selection	2102022
57748558	57748581	12	+	26627737	HCT116	viability after 18 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-0.5999263711484297	[466]	[75,117,259]	-5	hSpCas9	negative selection	2184332
57749218	57749241	12	+	26627737	HCT116	viability after 18 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-1.2900859075392785	[416]	[75,44,130]	-8	hSpCas9	negative selection	2184333
57750686	57750709	12	+	26627737	HCT116	viability after 18 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-1.3134407731711548	[600]	[51,46,262]	-8	hSpCas9	negative selection	2184334
57750922	57750945	12	-	26627737	HCT116	viability after 18 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.6265914910808388	[1498]	[508,445,453]	-5	hSpCas9	negative selection	2184335
57751202	57751225	12	+	26627737	HCT116	viability after 18 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	1.1333439817177315	[125]	[132,149,115]	8	hSpCas9	negative selection	2184336
57751528	57751551	12	-	26627737	HCT116	viability after 18 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-1.2858513522709236	[30]	[6,0,10]	-8	hSpCas9	negative selection	2184337
57751535	57751558	12	-	24336569	HL60	viability	TTCGTGAGGTGGCTTTACTGAGG	CDK4	ENSG00000135446	-1.2947194582465782	[1127]	[972]	-8	hSpCas9	negative selection	2256690
57751546	57751569	12	-	24336569	HL60	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	-0.6006245429543063	[899]	[1255]	-5	hSpCas9	negative selection	2256691
57751552	57751575	12	+	24336569	HL60	viability	CACGAACTGTGCTGATGGGAAGG	CDK4	ENSG00000135446	0.4410520452765656	[479]	[1378]	4	hSpCas9	negative selection	2256692
57751578	57751601	12	+	24336569	HL60	viability	CCTCCACCTCCTCCTCCATTGGG	CDK4	ENSG00000135446	-0.7358847376768887	[483]	[614]	-6	hSpCas9	negative selection	2256693
57751609	57751632	12	+	24336569	HL60	viability	CACTCTTGAGGGCCACAAAGTGG	CDK4	ENSG00000135446	0.3808935483901168	[805]	[2220]	3	hSpCas9	negative selection	2256694
57751618	57751641	12	+	24336569	HL60	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	1.1204787218955894	[202]	[933]	8	hSpCas9	negative selection	2256695
57751651	57751674	12	-	24336569	HL60	viability	TGCCTATGGGACAGTGTACAAGG	CDK4	ENSG00000135446	-0.2258540099640713	[356]	[645]	-2	hSpCas9	negative selection	2256696
57751664	57751687	12	-	24336569	HL60	viability	AAATTGGTGTCGGTGCCTATGGG	CDK4	ENSG00000135446	-0.2652853281842862	[162]	[286]	-2	hSpCas9	negative selection	2256697
57751674	57751697	12	+	24336569	HL60	viability	CCGACACCAATTTCAGCCACTGG	CDK4	ENSG00000135446	0.34323649600066686	[278]	[748]	3	hSpCas9	negative selection	2256698
57751688	57751711	12	+	24336569	HL60	viability	AGCCACTGGCTCATATCGAGAGG	CDK4	ENSG00000135446	0.15379238312050625	[637]	[1501]	1	hSpCas9	negative selection	2256699
57751535	57751558	12	-	24336569	KBM7	viability	TTCGTGAGGTGGCTTTACTGAGG	CDK4	ENSG00000135446	-0.06866843232127212	[555]	[1445]	0	hSpCas9	negative selection	2323867
57751546	57751569	12	-	24336569	KBM7	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	-0.00410768582001908	[470]	[1280]	0	hSpCas9	negative selection	2323868
57751552	57751575	12	+	24336569	KBM7	viability	CACGAACTGTGCTGATGGGAAGG	CDK4	ENSG00000135446	-0.04003067610823652	[506]	[1344]	0	hSpCas9	negative selection	2323869
57751578	57751601	12	+	24336569	KBM7	viability	CCTCCACCTCCTCCTCCATTGGG	CDK4	ENSG00000135446	-1.0528616816496346	[285]	[375]	-6	hSpCas9	negative selection	2323870
57751609	57751632	12	+	24336569	KBM7	viability	CACTCTTGAGGGCCACAAAGTGG	CDK4	ENSG00000135446	0.2975777328429745	[842]	[2825]	2	hSpCas9	negative selection	2323871
57751618	57751641	12	+	24336569	KBM7	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	1.1208951813837047	[219]	[1304]	8	hSpCas9	negative selection	2323872
57751651	57751674	12	-	24336569	KBM7	viability	TGCCTATGGGACAGTGTACAAGG	CDK4	ENSG00000135446	0.49780587640116736	[248]	[958]	4	hSpCas9	negative selection	2323873
57751664	57751687	12	-	24336569	KBM7	viability	AAATTGGTGTCGGTGCCTATGGG	CDK4	ENSG00000135446	0.6264213848948945	[94]	[399]	5	hSpCas9	negative selection	2323874
57751674	57751697	12	+	24336569	KBM7	viability	CCGACACCAATTTCAGCCACTGG	CDK4	ENSG00000135446	0.04175870056225392	[420]	[1181]	0	hSpCas9	negative selection	2323875
57751688	57751711	12	+	24336569	KBM7	viability	AGCCACTGGCTCATATCGAGAGG	CDK4	ENSG00000135446	-1.240468575139062	[582]	[672]	-7	hSpCas9	negative selection	2323876
57752612	57752635	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGCGGTGAGGGGGACAAGAGAGG	CDK4	ENSG00000135446	0.2229560178043311	[86,60]	[12,24]	1	dCas9-VP64	positive selection	2383212
57752584	57752607	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	GCTGCCACAACCCCCGCTGCAGG	CDK4	ENSG00000135446	1.0652453696778945	[172,126]	[72,63]	4	dCas9-VP64	positive selection	2383213
57752547	57752570	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGAGCAGAGGTGTGGCTACGCGG	CDK4	ENSG00000135446	2.1421163060942785	[119,74]	[32,160]	7	dCas9-VP64	positive selection	2383214
57754961	57754984	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	AGGGCGGGGATGCGCAGCCGCGG	CDK4	ENSG00000135446	-1.0213775973341104	[240,8]	[22,1]	-6	dCas9-VP64	positive selection	2463887
57754918	57754941	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCCACACTTGCCCCCGCCCCTGG	CDK4	ENSG00000135446	-0.9077178722029686	[309,264]	[27,38]	-5	dCas9-VP64	positive selection	2463888
57754936	57754959	12	-	25494202	A375	resistance to PLX-4720 (puromycin)	CCCGCACGAGCAGGTGTCCCAGG	CDK4	ENSG00000135446	1.8366053703867848	[209,999]	[9,989]	6	dCas9-VP64	positive selection	2463889
57752612	57752635	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGCGGTGAGGGGGACAAGAGAGG	CDK4	ENSG00000135446	0.04454062512470719	[150,156]	[14,84]	0	dCas9-VP64	positive selection	2478467
57752584	57752607	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	GCTGCCACAACCCCCGCTGCAGG	CDK4	ENSG00000135446	-0.03818271222025521	[63,116]	[14,40]	0	dCas9-VP64	positive selection	2478468
57752547	57752570	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGAGCAGAGGTGTGGCTACGCGG	CDK4	ENSG00000135446	-0.2039538737997257	[39,178]	[19,39]	-2	dCas9-VP64	positive selection	2478469
57754961	57754984	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	AGGGCGGGGATGCGCAGCCGCGG	CDK4	ENSG00000135446	0.10752739478325002	[81,19]	[30,5]	0	dCas9-VP64	positive selection	2559142
57754918	57754941	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCCACACTTGCCCCCGCCCCTGG	CDK4	ENSG00000135446	-0.014954718254812649	[240,133]	[62,57]	0	dCas9-VP64	positive selection	2559143
57754936	57754959	12	-	25494202	A375	resistance to PLX-4720 (zeocin)	CCCGCACGAGCAGGTGTCCCAGG	CDK4	ENSG00000135446	2.092244038732252	[68,22]	[18,106]	8	dCas9-VP64	positive selection	2559144
57751490	57751513	12	+	27013184	SW480	treatment with recombinant TRAIL	ACCTTCTCACCGGACAACATTGG	CDK4	ENSG00000135446	1.3586150803104604	[139,157]	[189,126]	6	hSpCas9	positive selection	2960216
57751491	57751514	12	+	27013184	SW480	treatment with recombinant TRAIL	CCTTCTCACCGGACAACATTGGG	CDK4	ENSG00000135446	-0.9309070873040952	[258,203]	[47,59]	-4	hSpCas9	positive selection	2960217
57751547	57751570	12	+	27013184	SW480	treatment with recombinant TRAIL	CACCTCACGAACTGTGCTGATGG	CDK4	ENSG00000135446	-0.02309923266636371	[323,537]	[178,178]	0	hSpCas9	positive selection	2960218
57751548	57751571	12	+	27013184	SW480	treatment with recombinant TRAIL	ACCTCACGAACTGTGCTGATGGG	CDK4	ENSG00000135446	-1.2513842901364765	[359,788]	[110,85]	-5	hSpCas9	positive selection	2960219
57751597	57751620	12	+	27013184	SW480	treatment with recombinant TRAIL	TGGGGACTCTCACACTCTTGAGG	CDK4	ENSG00000135446	-1.0302144260660682	[171,116]	[35,23]	-4	hSpCas9	positive selection	2960220
57751609	57751632	12	+	27013184	SW480	treatment with recombinant TRAIL	CACTCTTGAGGGCCACAAAGTGG	CDK4	ENSG00000135446	-0.28922157291659634	[112,46]	[32,23]	-1	hSpCas9	positive selection	2960221
57751628	57751651	12	+	27013184	SW480	treatment with recombinant TRAIL	GTGGCCACTGTGGGGATCACGGG	CDK4	ENSG00000135446	-0.993127124079836	[405,292]	[61,97]	-4	hSpCas9	positive selection	2960222
57751649	57751672	12	+	27013184	SW480	treatment with recombinant TRAIL	GGCCTTGTACACTGTCCCATAGG	CDK4	ENSG00000135446	1.108024040663831	[412,647]	[673,212]	5	hSpCas9	positive selection	2960223
57751674	57751697	12	+	27013184	SW480	treatment with recombinant TRAIL	CCGACACCAATTTCAGCCACTGG	CDK4	ENSG00000135446	1.4289387494578607	[350,488]	[432,548]	6	hSpCas9	positive selection	2960224
57751688	57751711	12	+	27013184	SW480	treatment with recombinant TRAIL	AGCCACTGGCTCATATCGAGAGG	CDK4	ENSG00000135446	2.5144560093833928	[167,333]	[648,531]	9	hSpCas9	positive selection	2960225
57751708	57751731	12	+	27013184	SW480	treatment with recombinant TRAIL	AGGTAGCCATTCTCAGATCAAGG	CDK4	ENSG00000135446	0.19353692346973306	[749,561]	[215,486]	1	hSpCas9	positive selection	2960226
57751709	57751732	12	+	27013184	SW480	treatment with recombinant TRAIL	GGTAGCCATTCTCAGATCAAGGG	CDK4	ENSG00000135446	1.4305463993228162	[245,333]	[196,525]	6	hSpCas9	positive selection	2960227
57751491	57751514	12	-	27013184	SW480	treatment with recombinant TRAIL	CCCAATGTTGTCCGGTGAGAAGG	CDK4	ENSG00000135446	2.159511713578013	[45,24]	[42,108]	8	hSpCas9	positive selection	2960228
57751499	57751522	12	-	27013184	SW480	treatment with recombinant TRAIL	TTGAGCATCCCAATGTTGTCCGG	CDK4	ENSG00000135446	0.40549217270790905	[89,50]	[18,72]	2	hSpCas9	positive selection	2960229
57751525	57751548	12	-	27013184	SW480	treatment with recombinant TRAIL	GGCTTTACTGAGGCGACTGGAGG	CDK4	ENSG00000135446	-2.0449820122537585	[101,122]	[2,23]	-7	hSpCas9	positive selection	2960230
57751528	57751551	12	-	27013184	SW480	treatment with recombinant TRAIL	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.8528390345184369	[162,218]	[103,207]	4	hSpCas9	positive selection	2960231
57751535	57751558	12	-	27013184	SW480	treatment with recombinant TRAIL	TTCGTGAGGTGGCTTTACTGAGG	CDK4	ENSG00000135446	1.4563077218281877	[97,84]	[94,128]	6	hSpCas9	positive selection	2960232
57751546	57751569	12	-	27013184	SW480	treatment with recombinant TRAIL	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	0.2796926469380814	[347,573]	[182,311]	1	hSpCas9	positive selection	2960233
57751549	57751572	12	-	27013184	SW480	treatment with recombinant TRAIL	TCCCATCAGCACAGTTCGTGAGG	CDK4	ENSG00000135446	-1.296309120429311	[397,337]	[34,107]	-5	hSpCas9	positive selection	2960234
57751587	57751610	12	-	27013184	SW480	treatment with recombinant TRAIL	GTGAGAGTCCCCAATGGAGGAGG	CDK4	ENSG00000135446	-0.5436308659237223	[72,79]	[10,38]	-2	hSpCas9	positive selection	2960235
57751590	57751613	12	-	27013184	SW480	treatment with recombinant TRAIL	AGTGTGAGAGTCCCCAATGGAGG	CDK4	ENSG00000135446	0.21274587342601126	[305,393]	[137,222]	1	hSpCas9	positive selection	2960236
57751593	57751616	12	-	27013184	SW480	treatment with recombinant TRAIL	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	-0.06346108974662168	[99,151]	[41,63]	0	hSpCas9	positive selection	2960237
57751632	57751655	12	-	27013184	SW480	treatment with recombinant TRAIL	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	1.5248208869387991	[394,621]	[530,743]	7	hSpCas9	positive selection	2960238
57751651	57751674	12	-	27013184	SW480	treatment with recombinant TRAIL	TGCCTATGGGACAGTGTACAAGG	CDK4	ENSG00000135446	0.06639779332213325	[315,232]	[128,120]	0	hSpCas9	positive selection	2960239
57751664	57751687	12	-	27013184	SW480	treatment with recombinant TRAIL	AAATTGGTGTCGGTGCCTATGGG	CDK4	ENSG00000135446	1.6435259547413381	[138,212]	[217,253]	7	hSpCas9	positive selection	2960240
57751665	57751688	12	-	27013184	SW480	treatment with recombinant TRAIL	GAAATTGGTGTCGGTGCCTATGG	CDK4	ENSG00000135446	-0.4923645640412937	[162,147]	[37,61]	-2	hSpCas9	positive selection	2960241
57751674	57751697	12	-	27013184	SW480	treatment with recombinant TRAIL	CCAGTGGCTGAAATTGGTGTCGG	CDK4	ENSG00000135446	0.05868624361872493	[254,227]	[151,47]	0	hSpCas9	positive selection	2960243
57751680	57751703	12	-	27013184	SW480	treatment with recombinant TRAIL	TATGAGCCAGTGGCTGAAATTGG	CDK4	ENSG00000135446	-1.6560547582568315	[74,45]	[12,1]	-6	hSpCas9	positive selection	2960245
57751690	57751713	12	-	27013184	SW480	treatment with recombinant TRAIL	TACCTCTCGATATGAGCCAGTGG	CDK4	ENSG00000135446	0.3503687489246374	[221,242]	[133,117]	1	hSpCas9	positive selection	2960246
57751714	57751737	12	-	27013184	SW480	treatment with recombinant TRAIL	GGTCTCCCTTGATCTGAGAATGG	CDK4	ENSG00000135446	-1.0348172973801928	[415,593]	[29,210]	-5	hSpCas9	positive selection	2960247
57751593	57751616	12	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	0.3346764268876086	[2,3]	[2,3]	7	hSpCas9	positive selection	2978193
57751674	57751697	12	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CCAGTGGCTGAAATTGGTGTCGG	CDK4	ENSG00000135446	-0.08827764154930902	[3,3]	[3,1]	-1	hSpCas9	positive selection	2978194
57751650	57751673	12	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGCCTTGTACACTGTCCCATAGG	CDK4	ENSG00000135446	0.02630739224437881	[3,3]	[2,3]	0	hSpCas9	positive selection	2978195
57751271	57751294	12	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTCTACATGCTCAAACACCAGGG	CDK4	ENSG00000135446	-0.6789299596341878	[3,3]	[3,0]	-8	hSpCas9	positive selection	2978196
57751593	57751616	12	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	-0.11088357019623635	[2,2]	[3,0]	-2	hSpCas9	positive selection	3046051
57751674	57751697	12	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CCAGTGGCTGAAATTGGTGTCGG	CDK4	ENSG00000135446	-0.11992009053252921	[3,3]	[3,1]	-2	hSpCas9	positive selection	3046052
57751650	57751673	12	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGCCTTGTACACTGTCCCATAGG	CDK4	ENSG00000135446	-0.7803344947760923	[3,3]	[1,0]	-9	hSpCas9	positive selection	3046053
57751271	57751294	12	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTCTACATGCTCAAACACCAGGG	CDK4	ENSG00000135446	0.2827173630253994	[3,3]	[2,3]	5	hSpCas9	positive selection	3046054
57751025	57751048		+	24336571	A375	resistance to PLX after 7 days	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.193509181915267	[29,27]	[25,24]	-6	hSpCas9	positive selection	3104615
57750922	57750945		+	24336571	A375	resistance to PLX after 7 days	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	0.17576392471290903	[7,9]	[10,8]	5	hSpCas9	positive selection	3104616
57751206	57751229		-	24336571	A375	resistance to PLX after 7 days	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.29763898138364675	[10,13]	[9,9]	-8	hSpCas9	positive selection	3104617
57751306	57751329		-	24336571	A375	resistance to PLX after 7 days	GTGCCACATCCCGAACTGACCGG	CDK4	ENSG00000135446	-0.3598441232669229	[11,12]	[9,8]	-8	hSpCas9	positive selection	3104619
57751025	57751048		+	24336571	A375	resistance to PLX after 14 days	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-1.3552301022168058	[36,24]	[4,4]	-9	hSpCas9	positive selection	3162408
57750922	57750945		+	24336571	A375	resistance to PLX after 14 days	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	0.5175563260497066	[7,9]	[7,3]	5	hSpCas9	positive selection	3162409
57751206	57751229		-	24336571	A375	resistance to PLX after 14 days	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.8203546880616817	[6,14]	[2,1]	-8	hSpCas9	positive selection	3162410
57751306	57751329		-	24336571	A375	resistance to PLX after 14 days	GTGCCACATCCCGAACTGACCGG	CDK4	ENSG00000135446	-1.1334899885289207	[13,15]	[2,2]	-9	hSpCas9	positive selection	3162412
57751025	57751048		+	24336571	A375	viability after 7 days	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	0.7379493765577746	[17]	[29,27]	9	hSpCas9	negative selection	3220201
57750922	57750945		+	24336571	A375	viability after 7 days	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	0.10209497518691868	[8]	[7,9]	1	hSpCas9	negative selection	3220202
57751206	57751229		-	24336571	A375	viability after 7 days	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.1514909202002836	[11]	[10,13]	2	hSpCas9	negative selection	3220203
57751306	57751329		-	24336571	A375	viability after 7 days	GTGCCACATCCCGAACTGACCGG	CDK4	ENSG00000135446	-0.14673279834984365	[13]	[11,12]	-2	hSpCas9	negative selection	3220205
57751025	57751048		+	24336571	A375	viability after 14 days	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	0.8305848821573522	[17]	[36,24]	9	hSpCas9	negative selection	3277994
57750922	57750945		+	24336571	A375	viability after 14 days	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	0.11290607439866995	[8]	[7,9]	1	hSpCas9	negative selection	3277995
57751206	57751229		-	24336571	A375	viability after 14 days	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.0037848448355976005	[11]	[6,14]	0	hSpCas9	negative selection	3277996
57751306	57751329		-	24336571	A375	viability after 14 days	GTGCCACATCCCGAACTGACCGG	CDK4	ENSG00000135446	0.17372088325393686	[13]	[13,15]	2	hSpCas9	negative selection	3277998
57751025	57751048	12	+	27383988	293T	resistance to West Nile virus (flavivirus)	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.7667089125709201	[229,290]	[0,0]	-5	hSpCas9	positive selection	3342414
57751296	57751319	12	+	27383988	293T	resistance to West Nile virus (flavivirus)	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	-1.6942442139965512	[509,479]	[0,0]	-9	hSpCas9	positive selection	3342415
57751206	57751229	12	-	27383988	293T	resistance to West Nile virus (flavivirus)	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	3.0315700790008697	[37,17]	[0,1]	8	hSpCas9	positive selection	3342416
57749467	57749490	12	-	27383988	293T	resistance to West Nile virus (flavivirus)	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	0.9174762085612103	[80,80]	[0,0]	4	hSpCas9	positive selection	3361646
57750922	57750945	12	+	27383988	293T	resistance to West Nile virus (flavivirus)	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	0.26864152467366925	[126,126]	[0,0]	1	hSpCas9	positive selection	3361647
57750751	57750774	12	-	27383988	293T	resistance to West Nile virus (flavivirus)	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.16893854325626279	[171,171]	[0,0]	-1	hSpCas9	positive selection	3361648
57751593	57751616	12	-	26780180	HT29	viability (Avana library 4 designs)	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	2.64875228086782	[]	[]	8	hSpCas9	negative selection	3414504
57751674	57751697	12	-	26780180	HT29	viability (Avana library 4 designs)	CCAGTGGCTGAAATTGGTGTCGG	CDK4	ENSG00000135446	1.23064183830573	[]	[]	5	hSpCas9	negative selection	3414505
57751649	57751672	12	+	26780180	HT29	viability (Avana library 4 designs)	GGCCTTGTACACTGTCCCATAGG	CDK4	ENSG00000135446	0.976488453994102	[]	[]	4	hSpCas9	negative selection	3414506
57751270	57751293	12	+	26780180	HT29	viability (Avana library 4 designs)	GTCTACATGCTCAAACACCAGGG	CDK4	ENSG00000135446	1.194955271798	[]	[]	4	hSpCas9	negative selection	3414507
57751270	57751293	12	+	26780180	A375	viability (Avana lentiCRISPRv2)	GTCTACATGCTCAAACACCAGGG	CDK4	ENSG00000135446	-2.53961606254308	[]	[]	-3	hSpCas9	negative selection	3491055
57751674	57751697	12	-	26780180	A375	viability (Avana lentiCRISPRv2)	CCAGTGGCTGAAATTGGTGTCGG	CDK4	ENSG00000135446	3.30914731538782	[]	[]	5	hSpCas9	negative selection	3491056
57751649	57751672	12	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGCCTTGTACACTGTCCCATAGG	CDK4	ENSG00000135446	-0.999784269564094	[]	[]	-1	hSpCas9	negative selection	3491057
57751593	57751616	12	-	26780180	A375	viability (Avana lentiCRISPRv2)	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	-0.291618264640607	[]	[]	0	hSpCas9	negative selection	3491058
57751499	57751522	12	-	26780180	A375	viability (Avana lentiCRISPRv2)	TTGAGCATCCCAATGTTGTCCGG	CDK4	ENSG00000135446	2.97143062174746	[]	[]	4	hSpCas9	negative selection	3491059
57751065	57751088	12	-	26780180	A375	viability (Avana lentiCRISPRv2)	CTGATGCGCCAGTTTCTAAGAGG	CDK4	ENSG00000135446	-0.0236594919097554	[]	[]	0	hSpCas9	negative selection	3491060
57751270	57751293	12	+	26780180	A375	viability (Avana lentiGuide)	GTCTACATGCTCAAACACCAGGG	CDK4	ENSG00000135446	2.96144889884287	[]	[]	3	hSpCas9	negative selection	3599714
57751674	57751697	12	-	26780180	A375	viability (Avana lentiGuide)	CCAGTGGCTGAAATTGGTGTCGG	CDK4	ENSG00000135446	2.30894537623156	[]	[]	2	hSpCas9	negative selection	3599715
57751649	57751672	12	+	26780180	A375	viability (Avana lentiGuide)	GGCCTTGTACACTGTCCCATAGG	CDK4	ENSG00000135446	6.99559363657923	[]	[]	5	hSpCas9	negative selection	3599716
57751593	57751616	12	-	26780180	A375	viability (Avana lentiGuide)	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	-0.296303007532547	[]	[]	0	hSpCas9	negative selection	3599717
57751499	57751522	12	-	26780180	A375	viability (Avana lentiGuide)	TTGAGCATCCCAATGTTGTCCGG	CDK4	ENSG00000135446	5.4417062467727	[]	[]	5	hSpCas9	negative selection	3599718
57751065	57751088	12	-	26780180	A375	viability (Avana lentiGuide)	CTGATGCGCCAGTTTCTAAGAGG	CDK4	ENSG00000135446	3.31536990474736	[]	[]	3	hSpCas9	negative selection	3599719
57751270	57751293	12	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTCTACATGCTCAAACACCAGGG	CDK4	ENSG00000135446	-0.8478990159717666	[5]	[3,1]	-8	hSpCas9	positive selection	3708373
57751674	57751697	12	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCAGTGGCTGAAATTGGTGTCGG	CDK4	ENSG00000135446	-0.04558767399168036	[4]	[5,3]	-1	hSpCas9	positive selection	3708374
57751649	57751672	12	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGCCTTGTACACTGTCCCATAGG	CDK4	ENSG00000135446	-0.11622906149162134	[4]	[4,3]	-2	hSpCas9	positive selection	3708375
57751593	57751616	12	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	-0.09060303361022004	[5]	[5,3]	-1	hSpCas9	positive selection	3708376
57751499	57751522	12	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTGAGCATCCCAATGTTGTCCGG	CDK4	ENSG00000135446	0.1969167954714857	[5]	[5,5]	5	hSpCas9	positive selection	3708377
57751065	57751088	12	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTGATGCGCCAGTTTCTAAGAGG	CDK4	ENSG00000135446	-0.4580830061620941	[4]	[4,1]	-6	hSpCas9	positive selection	3708378
57751270	57751293	12	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTCTACATGCTCAAACACCAGGG	CDK4	ENSG00000135446	-0.0647672486258497	[5]	[3,5]	-1	hSpCas9	positive selection	3816980
57751674	57751697	12	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCAGTGGCTGAAATTGGTGTCGG	CDK4	ENSG00000135446	-0.749704115116237	[5]	[2,2]	-7	hSpCas9	positive selection	3816981
57751649	57751672	12	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGCCTTGTACACTGTCCCATAGG	CDK4	ENSG00000135446	-0.5533166790178163	[5]	[3,1]	-6	hSpCas9	positive selection	3816982
57751593	57751616	12	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	0.13225066584512268	[5]	[4,5]	3	hSpCas9	positive selection	3816983
57751499	57751522	12	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTGAGCATCCCAATGTTGTCCGG	CDK4	ENSG00000135446	-0.15468580560035458	[6]	[3,5]	-2	hSpCas9	positive selection	3816984
57751065	57751088	12	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTGATGCGCCAGTTTCTAAGAGG	CDK4	ENSG00000135446	0.024617147323478132	[5]	[4,3]	0	hSpCas9	positive selection	3816985
57749467	57749490	12	-	26780180	A375	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	1.53005440687963	[]	[]	8	hSpCas9	negative selection	3925160
57751025	57751048	12	+	26780180	A375	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	0.983019151133063	[]	[]	4	hSpCas9	negative selection	3925161
57750922	57750945	12	+	26780180	A375	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	1.19070427353193	[]	[]	6	hSpCas9	negative selection	3925162
57750751	57750774	12	-	26780180	A375	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	2.32822095754371	[]	[]	9	hSpCas9	negative selection	3925163
57751296	57751319	12	+	26780180	A375	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.569800467569228	[]	[]	1	hSpCas9	negative selection	3925164
57751206	57751229	12	-	26780180	A375	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.673079221070897	[]	[]	2	hSpCas9	negative selection	3925165
57749467	57749490	12	-	26780180	HT29	viability (GeCKOv2 library)	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	1.72847608559155	[]	[]	8	hSpCas9	negative selection	4033126
57751025	57751048	12	+	26780180	HT29	viability (GeCKOv2 library)	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	0.613814145957363	[]	[]	2	hSpCas9	negative selection	4033127
57750922	57750945	12	+	26780180	HT29	viability (GeCKOv2 library)	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	1.83607987985879	[]	[]	8	hSpCas9	negative selection	4033128
57750751	57750774	12	-	26780180	HT29	viability (GeCKOv2 library)	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	0.802829786184115	[]	[]	3	hSpCas9	negative selection	4033129
57751296	57751319	12	+	26780180	HT29	viability (GeCKOv2 library)	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	-0.727066815854085	[]	[]	-9	hSpCas9	negative selection	4033130
57751206	57751229	12	-	26780180	HT29	viability (GeCKOv2 library)	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.802944664313901	[]	[]	3	hSpCas9	negative selection	4033131
57751025	57751048	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.22714145511812672	[4]	[2,2]	-5	hSpCas9	positive selection	4126644
57750922	57750945	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.06424753334429034	[3]	[1,2]	-1	hSpCas9	positive selection	4126645
57751206	57751229	12	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.519909314138081	[3]	[1,1]	-8	hSpCas9	positive selection	4126646
57751306	57751329	12	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GTGCCACATCCCGAACTGACCGG	CDK4	ENSG00000135446	-0.39267297573226656	[3]	[1,1]	-7	hSpCas9	positive selection	4126648
57751025	57751048	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	0.34367031377706375	[4]	[0,3,0,3]	2	hSpCas9	positive selection	4190666
57750922	57750945	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	0.36317817049054635	[3]	[2,2,3,0]	2	hSpCas9	positive selection	4190667
57751206	57751229	12	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.6509539143221534	[3]	[1,0,0,0]	-8	hSpCas9	positive selection	4190668
57751306	57751329	12	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GTGCCACATCCCGAACTGACCGG	CDK4	ENSG00000135446	0.12136742900106845	[3]	[3,1,1,0]	1	hSpCas9	positive selection	4190670
57751025	57751048	12	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	0.15237789587108447	[4]	[4,3]	3	hSpCas9	positive selection	4262467
57751296	57751319	12	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.40069725322123134	[4]	[4,4]	7	hSpCas9	positive selection	4262468
57751206	57751229	12	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.20976392996152737	[1]	[0,1]	4	hSpCas9	positive selection	4262469
57748608	57748631	12	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.1497076736499785	[2]	[2,1]	-3	hSpCas9	positive selection	4316800
57748614	57748637	12	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	-0.49946402488977537	[2]	[2,0]	-8	hSpCas9	positive selection	4316801
57748617	57748640	12	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.0421195399007015	[4]	[4,3]	0	hSpCas9	positive selection	4316802
57748645	57748668	12	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.5246368780654046	[3]	[4,3]	9	hSpCas9	positive selection	4316803
57749467	57749490	12	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.29276319547387664	[2]	[1,0]	-6	hSpCas9	positive selection	4326745
57750922	57750945	12	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.4882367497533124	[2]	[1,0]	-8	hSpCas9	positive selection	4326746
57750751	57750774	12	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.22570681998214454	[3]	[2,1]	-4	hSpCas9	positive selection	4326747
57751026	57751048	12	+	27760321	OCIAML3	viability	TCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-1.158013213439506	[269,259]	[33,169]	-8	hSpCas9	negative selection	4388061
57751203	57751225	12	+	27760321	OCIAML3	viability	TCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.09475824832101165	[1019,934]	[571,902]	-1	hSpCas9	negative selection	4388062
57751296	57751318	12	-	27760321	OCIAML3	viability	CGAACTGACCGGGAGATCAAGG	CDK4	ENSG00000135446	-1.1895368384098206	[604,479]	[160,215]	-8	hSpCas9	negative selection	4388063
57751491	57751513	12	+	27760321	OCIAML3	viability	CCTTCTCACCGGACAACATTGG	CDK4	ENSG00000135446	-1.246570026723209	[531,427]	[142,175]	-8	hSpCas9	negative selection	4388064
57751528	57751550	12	-	27760321	OCIAML3	viability	GTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-1.8120801306035266	[564,445]	[110,112]	-9	hSpCas9	negative selection	4388065
57751026	57751048	12	+	27760321	OCIAML2	viability	TCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.483873886117856	[269,259]	[134,177]	-5	hSpCas9	negative selection	4471524
57751203	57751225	12	+	27760321	OCIAML2	viability	TCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.28178344030602176	[1019,934]	[547,784]	-3	hSpCas9	negative selection	4471525
57751296	57751318	12	-	27760321	OCIAML2	viability	CGAACTGACCGGGAGATCAAGG	CDK4	ENSG00000135446	0.11483923726807249	[604,479]	[429,527]	1	hSpCas9	negative selection	4471526
57751491	57751513	12	+	27760321	OCIAML2	viability	CCTTCTCACCGGACAACATTGG	CDK4	ENSG00000135446	0.026088395313356674	[531,427]	[409,370]	0	hSpCas9	negative selection	4471527
57751528	57751550	12	-	27760321	OCIAML2	viability	GTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-0.035342298118625826	[564,445]	[345,462]	0	hSpCas9	negative selection	4471528
57751026	57751048	12	+	27760321	MV411	viability	TCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-1.0574514670684272	[269,259]	[46,139]	-6	hSpCas9	negative selection	4554987
57751203	57751225	12	+	27760321	MV411	viability	TCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.3427897437839572	[1019,934]	[374,708]	-2	hSpCas9	negative selection	4554988
57751296	57751318	12	-	27760321	MV411	viability	CGAACTGACCGGGAGATCAAGG	CDK4	ENSG00000135446	1.4212139281075964	[604,479]	[752,1252]	8	hSpCas9	negative selection	4554989
57751491	57751513	12	+	27760321	MV411	viability	CCTTCTCACCGGACAACATTGG	CDK4	ENSG00000135446	0.37626853063282767	[531,427]	[206,711]	2	hSpCas9	negative selection	4554990
57751528	57751550	12	-	27760321	MV411	viability	GTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.8489174238616866	[564,445]	[590,605]	6	hSpCas9	negative selection	4554991
57751026	57751048	12	+	27760321	HL60	viability	TCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.5914549727779661	[269,259]	[107,181]	-6	hSpCas9	negative selection	4638450
57751203	57751225	12	+	27760321	HL60	viability	TCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.06071524766572267	[1019,934]	[843,681]	0	hSpCas9	negative selection	4638451
57751296	57751318	12	-	27760321	HL60	viability	CGAACTGACCGGGAGATCAAGG	CDK4	ENSG00000135446	-0.46848852731097895	[604,479]	[261,377]	-5	hSpCas9	negative selection	4638452
57751491	57751513	12	+	27760321	HL60	viability	CCTTCTCACCGGACAACATTGG	CDK4	ENSG00000135446	0.015329207903224576	[531,427]	[445,338]	0	hSpCas9	negative selection	4638453
57751528	57751550	12	-	27760321	HL60	viability	GTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-0.0625110151831327	[564,445]	[372,413]	0	hSpCas9	negative selection	4638454
57751026	57751048	12	+	27760321	HT1080	viability	TCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-4.258407783633194	[259,202]	[0,8]	-8	hSpCas9	negative selection	4721913
57751203	57751225	12	+	27760321	HT1080	viability	TCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-2.324109830288103	[934,729]	[49,83]	-6	hSpCas9	negative selection	4721914
57751296	57751318	12	-	27760321	HT1080	viability	CGAACTGACCGGGAGATCAAGG	CDK4	ENSG00000135446	-2.1886740021569255	[479,374]	[65,5]	-6	hSpCas9	negative selection	4721915
57751491	57751513	12	+	27760321	HT1080	viability	CCTTCTCACCGGACAACATTGG	CDK4	ENSG00000135446	-1.4411603984224441	[427,333]	[0,115]	-5	hSpCas9	negative selection	4721916
57751528	57751550	12	-	27760321	HT1080	viability	GTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-3.3073567972791804	[445,347]	[25,4]	-7	hSpCas9	negative selection	4721917
57751026	57751048	12	+	27760321	HT29	viability after 7 days	TCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.12195502521247659	[259,202]	[279,200,337]	-2	hSpCas9	negative selection	4805376
57751203	57751225	12	+	27760321	HT29	viability after 7 days	TCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.30593866048659435	[934,729]	[724,819,1025]	-4	hSpCas9	negative selection	4805377
57751296	57751318	12	-	27760321	HT29	viability after 7 days	CGAACTGACCGGGAGATCAAGG	CDK4	ENSG00000135446	-0.02484521046801305	[479,374]	[617,689,329]	0	hSpCas9	negative selection	4805378
57751491	57751513	12	+	27760321	HT29	viability after 7 days	CCTTCTCACCGGACAACATTGG	CDK4	ENSG00000135446	0.13115163680584863	[427,333]	[294,767,511]	2	hSpCas9	negative selection	4805379
57751528	57751550	12	-	27760321	HT29	viability after 7 days	GTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-0.23752553692552364	[445,347]	[548,531,239]	-3	hSpCas9	negative selection	4805380
57751026	57751048	12	+	27760321	HT29	viability after 25 days	TCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	0.06563358581542966	[259,202]	[238,278,318]	0	hSpCas9	negative selection	4888839
57751203	57751225	12	+	27760321	HT29	viability after 25 days	TCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.4041964007489355	[934,729]	[765,622,768]	-4	hSpCas9	negative selection	4888840
57751296	57751318	12	-	27760321	HT29	viability after 25 days	CGAACTGACCGGGAGATCAAGG	CDK4	ENSG00000135446	0.2675366132293283	[479,374]	[841,433,457]	2	hSpCas9	negative selection	4888841
57751491	57751513	12	+	27760321	HT29	viability after 25 days	CCTTCTCACCGGACAACATTGG	CDK4	ENSG00000135446	-0.08910535491110773	[427,333]	[471,319,433]	-1	hSpCas9	negative selection	4888842
57751528	57751550	12	-	27760321	HT29	viability after 25 days	GTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.16412450053200345	[445,347]	[401,680,440]	1	hSpCas9	negative selection	4888843
57751026	57751048	12	+	27760321	HT29	viability after 22 days	TCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	0.23267264166342283	[259,202]	[405,316,216]	2	hSpCas9	negative selection	4972302
57751203	57751225	12	+	27760321	HT29	viability after 22 days	TCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.7024108411587267	[934,729]	[491,592,692]	-5	hSpCas9	negative selection	4972303
57751296	57751318	12	-	27760321	HT29	viability after 22 days	CGAACTGACCGGGAGATCAAGG	CDK4	ENSG00000135446	0.2686834211431929	[479,374]	[656,590,535]	2	hSpCas9	negative selection	4972304
57751491	57751513	12	+	27760321	HT29	viability after 22 days	CCTTCTCACCGGACAACATTGG	CDK4	ENSG00000135446	0.601738618236822	[427,333]	[986,505,501]	6	hSpCas9	negative selection	4972305
57751528	57751550	12	-	27760321	HT29	viability after 22 days	GTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.10028539961101576	[445,347]	[416,563,496]	1	hSpCas9	negative selection	4972306
57751026	57751048	12	+	27760321	HT29	viability after 19 days	TCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	0.6122612107852914	[259,202]	[660,502,88]	6	hSpCas9	negative selection	5055765
57751203	57751225	12	+	27760321	HT29	viability after 19 days	TCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.712692341543682	[934,729]	[444,774,510]	-5	hSpCas9	negative selection	5055766
57751296	57751318	12	-	27760321	HT29	viability after 19 days	CGAACTGACCGGGAGATCAAGG	CDK4	ENSG00000135446	0.5450281103726458	[479,374]	[836,637,678]	5	hSpCas9	negative selection	5055767
57751491	57751513	12	+	27760321	HT29	viability after 19 days	CCTTCTCACCGGACAACATTGG	CDK4	ENSG00000135446	-0.013941165917544532	[427,333]	[523,320,457]	0	hSpCas9	negative selection	5055768
57751528	57751550	12	-	27760321	HT29	viability after 19 days	GTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.3181282140993054	[445,347]	[616,463,619]	3	hSpCas9	negative selection	5055769
57751026	57751048	12	+	27760321	HT29	viability after 16 days	TCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.3147568215566008	[259,202]	[202,138,283]	-3	hSpCas9	negative selection	5139228
57751203	57751225	12	+	27760321	HT29	viability after 16 days	TCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.1855627627000076	[934,729]	[663,1134,634]	-2	hSpCas9	negative selection	5139229
57751296	57751318	12	-	27760321	HT29	viability after 16 days	CGAACTGACCGGGAGATCAAGG	CDK4	ENSG00000135446	0.4039437887080034	[479,374]	[661,489,752]	4	hSpCas9	negative selection	5139230
57751491	57751513	12	+	27760321	HT29	viability after 16 days	CCTTCTCACCGGACAACATTGG	CDK4	ENSG00000135446	-0.07933508381776785	[427,333]	[496,331,391]	-1	hSpCas9	negative selection	5139231
57751528	57751550	12	-	27760321	HT29	viability after 16 days	GTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-0.1415230141104509	[445,347]	[587,341,296]	-1	hSpCas9	negative selection	5139232
57751026	57751048	12	+	27760321	HT29	viability after 13 days	TCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	0.12353334601240573	[259,202]	[488,176,215]	1	hSpCas9	negative selection	5222691
57751203	57751225	12	+	27760321	HT29	viability after 13 days	TCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	0.020778279888327145	[934,729]	[879,1070,987]	0	hSpCas9	negative selection	5222692
57751296	57751318	12	-	27760321	HT29	viability after 13 days	CGAACTGACCGGGAGATCAAGG	CDK4	ENSG00000135446	-0.26237071331242884	[479,374]	[494,480,272]	-3	hSpCas9	negative selection	5222693
57751491	57751513	12	+	27760321	HT29	viability after 13 days	CCTTCTCACCGGACAACATTGG	CDK4	ENSG00000135446	0.4367742081877559	[427,333]	[640,595,559]	5	hSpCas9	negative selection	5222694
57751528	57751550	12	-	27760321	HT29	viability after 13 days	GTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-0.5387737779581796	[445,347]	[400,286,265]	-6	hSpCas9	negative selection	5222695
57751026	57751048	12	+	27760321	HT29	viability after 10 days	TCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	0.013216214669909632	[259,202]	[463,152,254]	0	hSpCas9	negative selection	5306154
57751203	57751225	12	+	27760321	HT29	viability after 10 days	TCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.33475888709316337	[934,729]	[862,837,772]	-4	hSpCas9	negative selection	5306155
57751296	57751318	12	-	27760321	HT29	viability after 10 days	CGAACTGACCGGGAGATCAAGG	CDK4	ENSG00000135446	0.33800589369426515	[479,374]	[702,500,811]	4	hSpCas9	negative selection	5306156
57751491	57751513	12	+	27760321	HT29	viability after 10 days	CCTTCTCACCGGACAACATTGG	CDK4	ENSG00000135446	-0.002173401875134137	[427,333]	[478,495,450]	0	hSpCas9	negative selection	5306157
57751528	57751550	12	-	27760321	HT29	viability after 10 days	GTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.01741459661438091	[445,347]	[405,604,496]	0	hSpCas9	negative selection	5306158
57751026	57751048	12	+	27760321	MOLM13	viability	TCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	1.0215513624359283	[269,259]	[67,504]	7	hSpCas9	negative selection	5389617
57751203	57751225	12	+	27760321	MOLM13	viability	TCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	0.069602182201556	[1019,934]	[731,447]	0	hSpCas9	negative selection	5389618
57751296	57751318	12	-	27760321	MOLM13	viability	CGAACTGACCGGGAGATCAAGG	CDK4	ENSG00000135446	-2.3199741606750814	[604,479]	[61,59]	-8	hSpCas9	negative selection	5389619
57751491	57751513	12	+	27760321	MOLM13	viability	CCTTCTCACCGGACAACATTGG	CDK4	ENSG00000135446	-0.31532609973586556	[531,427]	[203,226]	-2	hSpCas9	negative selection	5389620
57751528	57751550	12	-	27760321	MOLM13	viability	GTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-0.8668923974086507	[564,445]	[203,113]	-5	hSpCas9	negative selection	5389621
57752217	57752240	12	+	27661255	K562	viability	GGCCCCGGAGCCGGTTCCTACGG	CDK4	ENSG00000135446	0.1485348605165096	[545,697]	[577,522]	5	dCas9-KRAB	negative selection	5469908
57751025	57751048	12	+	27260156	BXPC3	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.12083571279270244	[1486]	[1175,1290,1468,1863]	-3	hSpCas9	negative selection	5534927
57751296	57751319	12	+	27260156	BXPC3	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.35798990720976076	[1390]	[1768,1818,1769,2128]	7	hSpCas9	negative selection	5534928
57751206	57751229	12	-	27260156	BXPC3	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.13298652776137154	[139]	[149,128,194,171]	3	hSpCas9	negative selection	5534929
57748608	57748631	12	+	27260156	BXPC3	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	0.1374731842446638	[418]	[478,496,425,525]	3	hSpCas9	negative selection	5589260
57748614	57748637	12	+	27260156	BXPC3	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.20255322533699313	[374]	[385,379,520,537]	4	hSpCas9	negative selection	5589261
57748617	57748640	12	-	27260156	BXPC3	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.43853596728067856	[1754]	[2142,2562,2649,2626]	8	hSpCas9	negative selection	5589262
57748645	57748668	12	-	27260156	BXPC3	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.46461240685319044	[506]	[745,711,700,764]	8	hSpCas9	negative selection	5589263
57749467	57749490	12	-	27260156	BXPC3	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	0.27748827020078215	[250]	[328,242,372,330]	6	hSpCas9	negative selection	5599205
57750922	57750945	12	+	27260156	BXPC3	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	0.09605968804359799	[312]	[357,286,368,390]	2	hSpCas9	negative selection	5599206
57750751	57750774	12	-	27260156	BXPC3	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	0.02050895140479103	[763]	[646,816,872,931]	0	hSpCas9	negative selection	5599207
57751025	57751048	12	+	27260156	A673	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.5521840562364664	[1486]	[1226,1166,1189,1290]	-8	hSpCas9	negative selection	5656178
57751296	57751319	12	+	27260156	A673	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	-0.1324345840952208	[1390]	[1653,1553,1337,1563]	-3	hSpCas9	negative selection	5656179
57751206	57751229	12	-	27260156	A673	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.4762315392057723	[139]	[105,99,207,63]	-8	hSpCas9	negative selection	5656180
57748608	57748631	12	+	27260156	A673	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.11145419547078825	[418]	[529,362,447,534]	-3	hSpCas9	negative selection	5710511
57748614	57748637	12	+	27260156	A673	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.6324287038378105	[374]	[589,679,686,828]	9	hSpCas9	negative selection	5710512
57748617	57748640	12	-	27260156	A673	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.29374711779823626	[1754]	[2858,2468,2472,2560]	7	hSpCas9	negative selection	5710513
57748645	57748668	12	-	27260156	A673	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.6510619876408259	[506]	[1216,686,950,1006]	9	hSpCas9	negative selection	5710514
57749467	57749490	12	-	27260156	A673	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.6715945887440764	[250]	[170,169,173,242]	-9	hSpCas9	negative selection	5720456
57750922	57750945	12	+	27260156	A673	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.7823388132495285	[312]	[212,279,158,219]	-9	hSpCas9	negative selection	5720457
57750751	57750774	12	-	27260156	A673	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.4786747236119925	[763]	[806,614,571,656]	-8	hSpCas9	negative selection	5720458
57751025	57751048	12	+	27260156	A375	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.40387101910002476	[1486]	[1283,1720,1378,960]	-5	hSpCas9	negative selection	5777429
57751296	57751319	12	+	27260156	A375	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.2114998699085513	[1390]	[1617,2290,2054,1637]	3	hSpCas9	negative selection	5777430
57751206	57751229	12	-	27260156	A375	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.42043251740858856	[139]	[202,246,104,311]	6	hSpCas9	negative selection	5777431
57748608	57748631	12	+	27260156	A375	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.41692854074098984	[418]	[382,372,464,257]	-5	hSpCas9	negative selection	5831762
57748614	57748637	12	+	27260156	A375	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.3953201545654603	[374]	[560,523,571,630]	6	hSpCas9	negative selection	5831763
57748617	57748640	12	-	27260156	A375	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.3783346126506615	[1754]	[2421,3106,2678,2516]	5	hSpCas9	negative selection	5831764
57748645	57748668	12	-	27260156	A375	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.9182594411018006	[506]	[1079,1574,1156,765]	9	hSpCas9	negative selection	5831765
57749467	57749490	12	-	27260156	A375	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	0.04186424692863089	[250]	[292,396,391,154]	0	hSpCas9	negative selection	5841707
57750922	57750945	12	+	27260156	A375	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.3135961598656576	[312]	[270,354,237,316]	-4	hSpCas9	negative selection	5841708
57750751	57750774	12	-	27260156	A375	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.15405230842135786	[763]	[916,613,906,747]	-2	hSpCas9	negative selection	5841709
57751025	57751048	12	+	27260156	COLO741	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.14007008267892762	[1486]	[1937,1561,1688]	-3	hSpCas9	negative selection	5898680
57751296	57751319	12	+	27260156	COLO741	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.2684470900590381	[1390]	[2263,1915,2239]	5	hSpCas9	negative selection	5898681
57751206	57751229	12	-	27260156	COLO741	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.1500758017047008	[139]	[210,143,237]	3	hSpCas9	negative selection	5898682
57748608	57748631	12	+	27260156	COLO741	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	0.12175080619680013	[418]	[701,581,479]	2	hSpCas9	negative selection	5953013
57748614	57748637	12	+	27260156	COLO741	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.13195427532560625	[374]	[433,601,529]	3	hSpCas9	negative selection	5953014
57748617	57748640	12	-	27260156	COLO741	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.5948089349537189	[1754]	[3263,3253,3606]	9	hSpCas9	negative selection	5953015
57748645	57748668	12	-	27260156	COLO741	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.6449917484024197	[506]	[1088,871,1076]	9	hSpCas9	negative selection	5953016
57749467	57749490	12	-	27260156	COLO741	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	0.37663337852913936	[250]	[476,370,405]	7	hSpCas9	negative selection	5962958
57750922	57750945	12	+	27260156	COLO741	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	0.015682351341919865	[312]	[542,269,409]	0	hSpCas9	negative selection	5962959
57750751	57750774	12	-	27260156	COLO741	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.21216004826700025	[763]	[807,882,832]	-4	hSpCas9	negative selection	5962960
57751025	57751048	12	+	27260156	CAL120	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-1.2214677704711725	[1486]	[709,879,777]	-9	hSpCas9	negative selection	6019931
57751296	57751319	12	+	27260156	CAL120	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	-0.8004961488706701	[1390]	[984,1015,978]	-8	hSpCas9	negative selection	6019932
57751206	57751229	12	-	27260156	CAL120	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.4180265930462008	[139]	[138,99,152]	-6	hSpCas9	negative selection	6019933
57748608	57748631	12	+	27260156	CAL120	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-1.6686550657979111	[418]	[200,103,191]	-9	hSpCas9	negative selection	6074264
57748614	57748637	12	+	27260156	CAL120	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.07323223697067188	[374]	[324,482,636]	1	hSpCas9	negative selection	6074265
57748617	57748640	12	-	27260156	CAL120	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	-0.09751951492440947	[1754]	[2152,1472,2504]	-1	hSpCas9	negative selection	6074266
57748645	57748668	12	-	27260156	CAL120	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.7363335902932899	[506]	[1444,884,884]	9	hSpCas9	negative selection	6074267
57749467	57749490	12	-	27260156	CAL120	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-1.9947101276712373	[250]	[92,49,93]	-9	hSpCas9	negative selection	6084209
57750922	57750945	12	+	27260156	CAL120	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-1.0459214584251133	[312]	[207,184,175]	-8	hSpCas9	negative selection	6084210
57750751	57750774	12	-	27260156	CAL120	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-1.1823417544984736	[763]	[562,281,432]	-9	hSpCas9	negative selection	6084211
57751025	57751048	12	+	27260156	CADOES1	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-1.0451643258920242	[1486]	[588,708,585,801]	-9	hSpCas9	negative selection	6141182
57751296	57751319	12	+	27260156	CADOES1	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.042497092595322306	[1390]	[1188,1190,1350,1608]	0	hSpCas9	negative selection	6141183
57751206	57751229	12	-	27260156	CADOES1	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.5735665475845613	[139]	[140,53,86,66]	-7	hSpCas9	negative selection	6141184
57748608	57748631	12	+	27260156	CADOES1	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.43374328811091445	[418]	[283,240,312,316]	-6	hSpCas9	negative selection	6195515
57748614	57748637	12	+	27260156	CADOES1	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.38519615821594205	[374]	[517,378,410,515]	6	hSpCas9	negative selection	6195516
57748617	57748640	12	-	27260156	CADOES1	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.24268537520909783	[1754]	[2132,1743,1843,2005]	4	hSpCas9	negative selection	6195517
57748645	57748668	12	-	27260156	CADOES1	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.647461518436927	[506]	[910,598,622,823]	9	hSpCas9	negative selection	6195518
57749467	57749490	12	-	27260156	CADOES1	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-1.0558671090590457	[250]	[69,97,199,79]	-9	hSpCas9	negative selection	6205460
57750922	57750945	12	+	27260156	CADOES1	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.5185090116723047	[312]	[177,249,233,148]	-7	hSpCas9	negative selection	6205461
57750751	57750774	12	-	27260156	CADOES1	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.8395558365318861	[763]	[356,441,404,383]	-9	hSpCas9	negative selection	6205462
57751025	57751048	12	+	27260156	EWS502	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-1.6031990209525404	[1486]	[476,614,491,485]	-9	hSpCas9	negative selection	6262433
57751296	57751319	12	+	27260156	EWS502	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	-0.29888737623099537	[1390]	[1193,1059,1083,1471]	-5	hSpCas9	negative selection	6262434
57751206	57751229	12	-	27260156	EWS502	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.6920960757778527	[139]	[89,73,79,125]	-8	hSpCas9	negative selection	6262435
57748608	57748631	12	+	27260156	EWS502	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-1.2781616151970159	[418]	[192,240,167,120]	-9	hSpCas9	negative selection	6316766
57748614	57748637	12	+	27260156	EWS502	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.1028088089395778	[374]	[294,460,514,450]	1	hSpCas9	negative selection	6316767
57748617	57748640	12	-	27260156	EWS502	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.07632912415596071	[1754]	[1640,1886,2141,2224]	1	hSpCas9	negative selection	6316768
57748645	57748668	12	-	27260156	EWS502	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.7136260405799528	[506]	[579,862,1049,1079]	9	hSpCas9	negative selection	6316769
57749467	57749490	12	-	27260156	EWS502	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-1.6941130968119251	[250]	[37,144,63,83]	-9	hSpCas9	negative selection	6326711
57750922	57750945	12	+	27260156	EWS502	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.9850589148423484	[312]	[52,109,215,317]	-8	hSpCas9	negative selection	6326712
57750751	57750774	12	-	27260156	EWS502	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-1.3184132336216692	[763]	[336,296,408,248]	-9	hSpCas9	negative selection	6326713
57751025	57751048	12	+	27260156	EW8	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.7637921219445336	[1486]	[707,759,661,714]	-8	hSpCas9	negative selection	6383684
57751296	57751319	12	+	27260156	EW8	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	-0.14079177842620294	[1390]	[1164,1141,817,1012]	-3	hSpCas9	negative selection	6383685
57751206	57751229	12	-	27260156	EW8	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.043666898787472874	[139]	[88,116,119,109]	-1	hSpCas9	negative selection	6383686
57748608	57748631	12	+	27260156	EW8	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.37057390574206184	[418]	[252,284,207,311]	-6	hSpCas9	negative selection	6438017
57748614	57748637	12	+	27260156	EW8	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.49180141941285127	[374]	[434,265,611,363]	8	hSpCas9	negative selection	6438018
57748617	57748640	12	-	27260156	EW8	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.40148668844562163	[1754]	[2109,1838,1637,1987]	7	hSpCas9	negative selection	6438019
57748645	57748668	12	-	27260156	EW8	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.721754706322687	[506]	[661,612,666,765]	9	hSpCas9	negative selection	6438020
57749467	57749490	12	-	27260156	EW8	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.04860323591028348	[250]	[219,363,130,85]	-1	hSpCas9	negative selection	6447962
57750922	57750945	12	+	27260156	EW8	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.620925304805605	[312]	[291,126,148,107]	-8	hSpCas9	negative selection	6447963
57750751	57750774	12	-	27260156	EW8	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.6762324063595784	[763]	[411,462,249,449]	-8	hSpCas9	negative selection	6447964
57751025	57751048	12	+	27260156	CORL105	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.3104183376143532	[1486]	[1430,1385,1434,1368]	-5	hSpCas9	negative selection	6504935
57751296	57751319	12	+	27260156	CORL105	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.1569729441328569	[1390]	[1954,1626,2052,1672]	3	hSpCas9	negative selection	6504936
57751206	57751229	12	-	27260156	CORL105	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.3256518975669689	[139]	[149,104,166,107]	-5	hSpCas9	negative selection	6504937
57748608	57748631	12	+	27260156	CORL105	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.09470375602062434	[418]	[431,477,509,423]	-2	hSpCas9	negative selection	6559268
57748614	57748637	12	+	27260156	CORL105	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.2725788008727592	[374]	[461,407,665,605]	5	hSpCas9	negative selection	6559269
57748617	57748640	12	-	27260156	CORL105	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.4292977865534602	[1754]	[2848,2550,3116,2610]	7	hSpCas9	negative selection	6559270
57748645	57748668	12	-	27260156	CORL105	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.6773552257205553	[506]	[840,910,968,1074]	9	hSpCas9	negative selection	6559271
57749467	57749490	12	-	27260156	CORL105	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.28283339335700597	[250]	[314,182,242,228]	-5	hSpCas9	negative selection	6569213
57750922	57750945	12	+	27260156	CORL105	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.04230882433220862	[312]	[332,370,423,304]	-1	hSpCas9	negative selection	6569214
57750751	57750774	12	-	27260156	CORL105	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.12836177354018863	[763]	[674,941,784,857]	-2	hSpCas9	negative selection	6569215
57751025	57751048	12	+	27260156	HS294T	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.6025727125460487	[1486]	[196,313,324,760]	-7	hSpCas9	negative selection	6626186
57751296	57751319	12	+	27260156	HS294T	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.19334144392154418	[1390]	[655,506,651,647]	2	hSpCas9	negative selection	6626187
57751206	57751229	12	-	27260156	HS294T	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.09715389614717695	[139]	[39,91,46,51]	1	hSpCas9	negative selection	6626188
57748608	57748631	12	+	27260156	HS294T	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.21337428802292271	[418]	[124,113,175,146]	-3	hSpCas9	negative selection	6680519
57748614	57748637	12	+	27260156	HS294T	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.05331460060306381	[374]	[103,99,205,206]	0	hSpCas9	negative selection	6680520
57748617	57748640	12	-	27260156	HS294T	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.28562847476388065	[1754]	[831,723,834,935]	4	hSpCas9	negative selection	6680521
57748645	57748668	12	-	27260156	HS294T	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.48062316993932047	[506]	[305,276,187,327]	6	hSpCas9	negative selection	6680522
57749467	57749490	12	-	27260156	HS294T	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.21448994259846077	[250]	[40,107,107,79]	-3	hSpCas9	negative selection	6690464
57750922	57750945	12	+	27260156	HS294T	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.10656234608710147	[312]	[92,65,164,131]	-1	hSpCas9	negative selection	6690465
57750751	57750774	12	-	27260156	HS294T	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.9076635397254398	[763]	[107,144,176,213]	-8	hSpCas9	negative selection	6690466
57751025	57751048	12	+	27260156	HCC44	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.17892291308268904	[1486]	[1445,1347,1864,1356]	-3	hSpCas9	negative selection	6747437
57751296	57751319	12	+	27260156	HCC44	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.45603751607585363	[1390]	[2629,1834,2171,2071]	7	hSpCas9	negative selection	6747438
57751206	57751229	12	-	27260156	HCC44	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.4254963566622805	[139]	[398,164,119,173]	7	hSpCas9	negative selection	6747439
57748608	57748631	12	+	27260156	HCC44	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.19504542616185874	[418]	[446,304,488,441]	-3	hSpCas9	negative selection	6801770
57748614	57748637	12	+	27260156	HCC44	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.32419889466644886	[374]	[650,432,472,575]	5	hSpCas9	negative selection	6801771
57748617	57748640	12	-	27260156	HCC44	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.4418423291550604	[1754]	[2699,2493,2736,2861]	7	hSpCas9	negative selection	6801772
57748645	57748668	12	-	27260156	HCC44	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.5810970726341331	[506]	[864,768,1009,820]	8	hSpCas9	negative selection	6801773
57749467	57749490	12	-	27260156	HCC44	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.27809127387420185	[250]	[299,314,158,144]	-4	hSpCas9	negative selection	6811715
57750922	57750945	12	+	27260156	HCC44	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	0.544125308175385	[312]	[321,483,658,603]	8	hSpCas9	negative selection	6811716
57750751	57750774	12	-	27260156	HCC44	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.03817445537225017	[763]	[796,635,1409,645]	0	hSpCas9	negative selection	6811717
57751025	57751048	12	+	27260156	G402	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.7616297073076136	[1486]	[1228,769,1039,1234]	-7	hSpCas9	negative selection	6868688
57751296	57751319	12	+	27260156	G402	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	-0.6427537824279049	[1390]	[1095,1249,1007,1004]	-7	hSpCas9	negative selection	6868689
57751206	57751229	12	-	27260156	G402	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.49615787902671604	[139]	[93,179,98,110]	-6	hSpCas9	negative selection	6868690
57748608	57748631	12	+	27260156	G402	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-1.0604463119298073	[418]	[265,187,315,210]	-8	hSpCas9	negative selection	6923021
57748614	57748637	12	+	27260156	G402	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.2672340798041167	[374]	[569,736,520,393]	3	hSpCas9	negative selection	6923022
57748617	57748640	12	-	27260156	G402	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.5851608726515725	[1754]	[3845,3042,2995,3042]	7	hSpCas9	negative selection	6923023
57748645	57748668	12	-	27260156	G402	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.796315947057761	[506]	[1557,572,746,1437]	8	hSpCas9	negative selection	6923024
57749467	57749490	12	-	27260156	G402	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-1.156374735448569	[250]	[144,260,90,63]	-8	hSpCas9	negative selection	6932966
57750922	57750945	12	+	27260156	G402	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.8530637172623495	[312]	[107,286,219,218]	-7	hSpCas9	negative selection	6932967
57750751	57750774	12	-	27260156	G402	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-1.4731243951255608	[763]	[173,647,249,267]	-9	hSpCas9	negative selection	6932968
57751025	57751048	12	+	27260156	L33	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.025817375514944896	[1486]	[1391,567,1105,1308]	0	hSpCas9	negative selection	6989939
57751296	57751319	12	+	27260156	L33	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.3684938213152473	[1390]	[1886,707,1212,1637]	7	hSpCas9	negative selection	6989940
57751206	57751229	12	-	27260156	L33	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.013926739454859893	[139]	[122,53,138,79]	0	hSpCas9	negative selection	6989941
57748608	57748631	12	+	27260156	L33	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	0.23753394558194676	[418]	[402,204,277,630]	5	hSpCas9	negative selection	7044272
57748614	57748637	12	+	27260156	L33	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.34334754238889437	[374]	[427,237,249,496]	7	hSpCas9	negative selection	7044273
57748617	57748640	12	-	27260156	L33	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.5502181986943406	[1754]	[2581,1071,1594,2542]	9	hSpCas9	negative selection	7044274
57748645	57748668	12	-	27260156	L33	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.7321668699768022	[506]	[964,292,519,857]	9	hSpCas9	negative selection	7044275
57749467	57749490	12	-	27260156	L33	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.0465973896616626	[250]	[194,111,142,276]	-1	hSpCas9	negative selection	7054217
57750922	57750945	12	+	27260156	L33	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.3794270680148336	[312]	[250,87,143,266]	-7	hSpCas9	negative selection	7054218
57750751	57750774	12	-	27260156	L33	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.0847412593371707	[763]	[657,274,586,621]	-2	hSpCas9	negative selection	7054219
57751025	57751048	12	+	27260156	K562	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	0.044914759511613944	[1486]	[1507,1287,1849,860]	0	hSpCas9	negative selection	7111190
57751296	57751319	12	+	27260156	K562	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.4067449900569	[1390]	[1591,1948,1962,1109]	5	hSpCas9	negative selection	7111191
57751206	57751229	12	-	27260156	K562	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.5656480614918868	[139]	[192,241,57,238]	7	hSpCas9	negative selection	7111192
57748608	57748631	12	+	27260156	K562	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.25422536361013304	[418]	[343,272,342,288]	-3	hSpCas9	negative selection	7165523
57748614	57748637	12	+	27260156	K562	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.3506149614662318	[374]	[468,323,599,313]	4	hSpCas9	negative selection	7165524
57748617	57748640	12	-	27260156	K562	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.518806638312812	[1754]	[2261,2036,2740,1906]	6	hSpCas9	negative selection	7165525
57748645	57748668	12	-	27260156	K562	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.7589289271137227	[506]	[713,591,1098,638]	8	hSpCas9	negative selection	7165526
57749467	57749490	12	-	27260156	K562	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.3674127318467786	[250]	[226,312,66,102]	-4	hSpCas9	negative selection	7175468
57750922	57750945	12	+	27260156	K562	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	0.08698205005959014	[312]	[386,211,268,311]	1	hSpCas9	negative selection	7175469
57750751	57750774	12	-	27260156	K562	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.6619649833309986	[763]	[409,527,406,376]	-7	hSpCas9	negative selection	7175470
57751025	57751048	12	+	27260156	HT29	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.1777247632413066	[1486]	[1915,1333,1780,1378]	-4	hSpCas9	negative selection	7232441
57751296	57751319	12	+	27260156	HT29	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.373810158399144	[1390]	[2423,2364,2186,1847]	7	hSpCas9	negative selection	7232442
57751206	57751229	12	-	27260156	HT29	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.20829184563131675	[139]	[201,121,248,204]	4	hSpCas9	negative selection	7232443
57748608	57748631	12	+	27260156	HT29	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	0.28041344772638144	[418]	[636,623,826,409]	5	hSpCas9	negative selection	7286774
57748614	57748637	12	+	27260156	HT29	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.19580442287677044	[374]	[613,486,539,455]	4	hSpCas9	negative selection	7286775
57748617	57748640	12	-	27260156	HT29	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.5899240033866335	[1754]	[3599,3392,3240,2696]	9	hSpCas9	negative selection	7286776
57748645	57748668	12	-	27260156	HT29	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.8308742260826567	[506]	[1076,1234,1144,948]	9	hSpCas9	negative selection	7286777
57749467	57749490	12	-	27260156	HT29	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	0.07268480587988424	[250]	[246,337,433,264]	1	hSpCas9	negative selection	7296719
57750922	57750945	12	+	27260156	HT29	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.21844958301562856	[312]	[310,259,447,284]	-4	hSpCas9	negative selection	7296720
57750751	57750774	12	-	27260156	HT29	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.01784788244507629	[763]	[1102,999,843,756]	0	hSpCas9	negative selection	7296721
57751025	57751048	12	+	27260156	MHHES1	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-1.0674375496499162	[1486]	[1023,888,650,677]	-9	hSpCas9	negative selection	7353692
57751296	57751319	12	+	27260156	MHHES1	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	-0.2784838953953783	[1390]	[1522,1115,1412,1132]	-5	hSpCas9	negative selection	7353693
57751206	57751229	12	-	27260156	MHHES1	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-1.020070270159203	[139]	[133,85,56,46]	-9	hSpCas9	negative selection	7353694
57748608	57748631	12	+	27260156	MHHES1	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.42682948802888543	[418]	[321,438,369,285]	-7	hSpCas9	negative selection	7408025
57748614	57748637	12	+	27260156	MHHES1	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.04055178636223705	[374]	[396,484,568,307]	0	hSpCas9	negative selection	7408026
57748617	57748640	12	-	27260156	MHHES1	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.49075608950057337	[1754]	[2666,3177,2644,2618]	8	hSpCas9	negative selection	7408027
57748645	57748668	12	-	27260156	MHHES1	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.9012214355904145	[506]	[1288,1180,855,973]	9	hSpCas9	negative selection	7408028
57749467	57749490	12	-	27260156	MHHES1	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-1.2699276883170152	[250]	[76,263,44,94]	-9	hSpCas9	negative selection	7417970
57750922	57750945	12	+	27260156	MHHES1	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.48875119308991744	[312]	[298,276,346,116]	-7	hSpCas9	negative selection	7417971
57750751	57750774	12	-	27260156	MHHES1	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.8394085898745647	[763]	[511,525,607,314]	-9	hSpCas9	negative selection	7417972
57751025	57751048	12	+	27260156	MEWO	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.4053172210722471	[1486]	[1331,974,898]	-7	hSpCas9	negative selection	7474943
57751296	57751319	12	+	27260156	MEWO	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.16982660017239581	[1390]	[1756,1312,1378]	4	hSpCas9	negative selection	7474944
57751206	57751229	12	-	27260156	MEWO	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.20049110962348093	[139]	[113,99,127]	-4	hSpCas9	negative selection	7474945
57748608	57748631	12	+	27260156	MEWO	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	0.051465919335445975	[418]	[507,269,460]	1	hSpCas9	negative selection	7529276
57748614	57748637	12	+	27260156	MEWO	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.013662046982855502	[374]	[353,437,269]	0	hSpCas9	negative selection	7529277
57748617	57748640	12	-	27260156	MEWO	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.5647616301604259	[1754]	[2537,2738,2027]	9	hSpCas9	negative selection	7529278
57748645	57748668	12	-	27260156	MEWO	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.4389620717590567	[506]	[594,765,557]	8	hSpCas9	negative selection	7529279
57749467	57749490	12	-	27260156	MEWO	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.30521492780521653	[250]	[256,205,119]	-6	hSpCas9	negative selection	7539221
57750922	57750945	12	+	27260156	MEWO	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.4449881775427772	[312]	[295,205,158]	-7	hSpCas9	negative selection	7539222
57750751	57750774	12	-	27260156	MEWO	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	0.004332334130707438	[763]	[739,730,683]	0	hSpCas9	negative selection	7539223
57751025	57751048	12	+	27260156	LNCAPCLONEFGC	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-1.1666146233891164	[1486]	[531,645,720,516]	-9	hSpCas9	negative selection	7596194
57751296	57751319	12	+	27260156	LNCAPCLONEFGC	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	-0.6915029793444449	[1390]	[612,713,988,842]	-8	hSpCas9	negative selection	7596195
57751206	57751229	12	-	27260156	LNCAPCLONEFGC	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.5707666149058772	[139]	[48,64,128,106]	-7	hSpCas9	negative selection	7596196
57748608	57748631	12	+	27260156	LNCAPCLONEFGC	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.8971251242004324	[418]	[249,130,277,170]	-8	hSpCas9	negative selection	7650527
57748614	57748637	12	+	27260156	LNCAPCLONEFGC	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.21961644617682838	[374]	[350,320,484,443]	3	hSpCas9	negative selection	7650528
57748617	57748640	12	-	27260156	LNCAPCLONEFGC	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.22929670851302664	[1754]	[1958,1459,2091,2000]	3	hSpCas9	negative selection	7650529
57748645	57748668	12	-	27260156	LNCAPCLONEFGC	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.8397086616131073	[506]	[750,896,884,759]	9	hSpCas9	negative selection	7650530
57749467	57749490	12	-	27260156	LNCAPCLONEFGC	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.5379825960352611	[250]	[212,115,143,152]	-7	hSpCas9	negative selection	7660472
57750922	57750945	12	+	27260156	LNCAPCLONEFGC	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.5579392420795212	[312]	[210,186,237,140]	-7	hSpCas9	negative selection	7660473
57750751	57750774	12	-	27260156	LNCAPCLONEFGC	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.997809627348593	[763]	[362,287,335,400]	-8	hSpCas9	negative selection	7660474
57751025	57751048	12	+	27260156	PANC0327	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	0.0035638287216357423	[1486]	[1429,1138,1394,1364]	0	hSpCas9	negative selection	7717445
57751296	57751319	12	+	27260156	PANC0327	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.6031071950285061	[1390]	[1962,1679,1678,2216]	8	hSpCas9	negative selection	7717446
57751206	57751229	12	-	27260156	PANC0327	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-1.0118545265826628	[139]	[48,89,65,36]	-8	hSpCas9	negative selection	7717447
57748608	57748631	12	+	27260156	PANC0327	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.23034426941941413	[418]	[375,368,223,297]	-3	hSpCas9	negative selection	7771778
57748614	57748637	12	+	27260156	PANC0327	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.33771907070060325	[374]	[627,234,525,335]	5	hSpCas9	negative selection	7771779
57748617	57748640	12	-	27260156	PANC0327	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.1661706815549926	[1754]	[2170,1448,1736,1712]	2	hSpCas9	negative selection	7771780
57748645	57748668	12	-	27260156	PANC0327	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.8255357254345903	[506]	[1008,740,756,709]	9	hSpCas9	negative selection	7771781
57749467	57749490	12	-	27260156	PANC0327	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.6761843727761299	[250]	[113,162,147,127]	-7	hSpCas9	negative selection	7781723
57750922	57750945	12	+	27260156	PANC0327	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	0.013526533926428774	[312]	[225,363,135,380]	0	hSpCas9	negative selection	7781724
57750751	57750774	12	-	27260156	PANC0327	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.06717583980346209	[763]	[618,729,630,597]	-1	hSpCas9	negative selection	7781725
57751025	57751048	12	+	27260156	NCIH2009	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.3082036233546668	[1486]	[1972,1253,1869]	-4	hSpCas9	negative selection	7838696
57751296	57751319	12	+	27260156	NCIH2009	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.41071085393890927	[1390]	[2981,1970,2882]	5	hSpCas9	negative selection	7838697
57751206	57751229	12	-	27260156	NCIH2009	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.13160355725947448	[139]	[222,280,138]	1	hSpCas9	negative selection	7838698
57748608	57748631	12	+	27260156	NCIH2009	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	0.04764027190991382	[418]	[583,659,564]	0	hSpCas9	negative selection	7893029
57748614	57748637	12	+	27260156	NCIH2009	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.1916449131977638	[374]	[550,582,650]	2	hSpCas9	negative selection	7893030
57748617	57748640	12	-	27260156	NCIH2009	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.5967386585172321	[1754]	[4212,3375,3634]	7	hSpCas9	negative selection	7893031
57748645	57748668	12	-	27260156	NCIH2009	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.8754521475584089	[506]	[1357,1187,1363]	9	hSpCas9	negative selection	7893032
57749467	57749490	12	-	27260156	NCIH2009	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.7177007986231714	[250]	[136,118,369]	-7	hSpCas9	negative selection	7902974
57750922	57750945	12	+	27260156	NCIH2009	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	0.13652129993077367	[312]	[338,497,575]	1	hSpCas9	negative selection	7902975
57750751	57750774	12	-	27260156	NCIH2009	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.14066325455530826	[763]	[1041,787,1090]	-2	hSpCas9	negative selection	7902976
57751025	57751048	12	+	27260156	NCIH1373	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.004864667804542755	[1486]	[2147,1183,2245,299]	0	hSpCas9	negative selection	7959947
57751296	57751319	12	+	27260156	NCIH1373	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.4283694007709531	[1390]	[2539,1589,1959,640]	4	hSpCas9	negative selection	7959948
57751206	57751229	12	-	27260156	NCIH1373	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.17601717105308667	[139]	[99,426,68,17]	1	hSpCas9	negative selection	7959949
57748608	57748631	12	+	27260156	NCIH1373	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.17325649841515536	[418]	[760,325,400,59]	-2	hSpCas9	negative selection	8014280
57748614	57748637	12	+	27260156	NCIH1373	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.6753142309278586	[374]	[498,433,1131,157]	6	hSpCas9	negative selection	8014281
57748617	57748640	12	-	27260156	NCIH1373	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.7480594723160454	[1754]	[3335,2817,3234,1025]	7	hSpCas9	negative selection	8014282
57748645	57748668	12	-	27260156	NCIH1373	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	1.234474671493911	[506]	[1430,1445,998,389]	9	hSpCas9	negative selection	8014283
57749467	57749490	12	-	27260156	NCIH1373	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.5887175515479874	[250]	[298,119,222,32]	-5	hSpCas9	negative selection	8024225
57750922	57750945	12	+	27260156	NCIH1373	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.8721938241335588	[312]	[303,130,73,75]	-7	hSpCas9	negative selection	8024226
57750751	57750774	12	-	27260156	NCIH1373	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.460057964744594	[763]	[814,520,568,163]	-4	hSpCas9	negative selection	8024227
57751025	57751048	12	+	27260156	PATU8902	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	0.10522797877636836	[1486]	[1890,2130,1542,3683]	1	hSpCas9	negative selection	8081198
57751296	57751319	12	+	27260156	PATU8902	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.5015165365189878	[1390]	[3182,2613,1885,3581]	5	hSpCas9	negative selection	8081199
57751206	57751229	12	-	27260156	PATU8902	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.3574471347158501	[139]	[163,247,358,191]	3	hSpCas9	negative selection	8081200
57748608	57748631	12	+	27260156	PATU8902	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.2350391250667033	[418]	[351,736,598,235]	-2	hSpCas9	negative selection	8135531
57748614	57748637	12	+	27260156	PATU8902	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	1.2599868140297066	[374]	[1465,1874,676,1105]	9	hSpCas9	negative selection	8135532
57748617	57748640	12	-	27260156	PATU8902	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.6331205864388791	[1754]	[3245,5015,2712,4537]	6	hSpCas9	negative selection	8135533
57748645	57748668	12	-	27260156	PATU8902	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.9607003985195692	[506]	[1445,1263,773,2262]	9	hSpCas9	negative selection	8135534
57749467	57749490	12	-	27260156	PATU8902	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.41731473855595547	[250]	[409,287,200,145]	-4	hSpCas9	negative selection	8145476
57750922	57750945	12	+	27260156	PATU8902	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	0.13466239144371456	[312]	[432,331,515,638]	1	hSpCas9	negative selection	8145477
57750751	57750774	12	-	27260156	PATU8902	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.28392822763444986	[763]	[863,925,563,1261]	-3	hSpCas9	negative selection	8145478
57751025	57751048	12	+	27260156	PANC1	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.09056205435424025	[1486]	[1210,1319,1135,1143]	-1	hSpCas9	negative selection	8202449
57751296	57751319	12	+	27260156	PANC1	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.48055944091903524	[1390]	[1560,2274,1691,1300]	7	hSpCas9	negative selection	8202450
57751206	57751229	12	-	27260156	PANC1	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.008062028918059516	[139]	[78,158,134,117]	0	hSpCas9	negative selection	8202451
57748608	57748631	12	+	27260156	PANC1	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	0.5860791119982867	[418]	[537,798,462,423]	8	hSpCas9	negative selection	8256782
57748614	57748637	12	+	27260156	PANC1	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.2775716760180518	[374]	[385,556,285,363]	4	hSpCas9	negative selection	8256783
57748617	57748640	12	-	27260156	PANC1	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.48123330398340736	[1754]	[2019,2422,1919,2086]	7	hSpCas9	negative selection	8256784
57748645	57748668	12	-	27260156	PANC1	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.7476671343286168	[506]	[773,979,749,497]	9	hSpCas9	negative selection	8256785
57749467	57749490	12	-	27260156	PANC1	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.8177031794033689	[250]	[88,160,130,115]	-8	hSpCas9	negative selection	8266727
57750922	57750945	12	+	27260156	PANC1	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.340814201193409	[312]	[226,180,199,227]	-5	hSpCas9	negative selection	8266728
57750751	57750774	12	-	27260156	PANC1	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.19310300469605102	[763]	[533,522,683,541]	-3	hSpCas9	negative selection	8266729
57751025	57751048	12	+	27260156	PANC0813	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.059248714674302594	[1486]	[2047,1481,1673,1540]	-1	hSpCas9	negative selection	8323700
57751296	57751319	12	+	27260156	PANC0813	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.6009473945724968	[1390]	[2933,2196,2455,2369]	8	hSpCas9	negative selection	8323701
57751206	57751229	12	-	27260156	PANC0813	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.01666473174487293	[139]	[210,143,126,185]	0	hSpCas9	negative selection	8323702
57748608	57748631	12	+	27260156	PANC0813	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	0.2118911544179877	[418]	[796,491,532,482]	3	hSpCas9	negative selection	8378033
57748614	57748637	12	+	27260156	PANC0813	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.5386057897956156	[374]	[990,490,724,397]	8	hSpCas9	negative selection	8378034
57748617	57748640	12	-	27260156	PANC0813	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.5162558830731041	[1754]	[3605,2904,2937,2429]	8	hSpCas9	negative selection	8378035
57748645	57748668	12	-	27260156	PANC0813	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.7712835350149596	[506]	[909,899,929,1297]	9	hSpCas9	negative selection	8378036
57749467	57749490	12	-	27260156	PANC0813	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	0.09079715125320353	[250]	[415,295,349,208]	1	hSpCas9	negative selection	8387978
57750922	57750945	12	+	27260156	PANC0813	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.23172659692934727	[312]	[442,323,246,252]	-4	hSpCas9	negative selection	8387979
57750751	57750774	12	-	27260156	PANC0813	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.045891908092688394	[763]	[921,947,773,837]	0	hSpCas9	negative selection	8387980
57751025	57751048	12	+	27260156	RDES	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-1.6593794773843844	[1486]	[551,491,629,466]	-9	hSpCas9	negative selection	8444951
57751296	57751319	12	+	27260156	RDES	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	-0.25515443591864995	[1390]	[1094,1257,1139,1978]	-4	hSpCas9	negative selection	8444952
57751206	57751229	12	-	27260156	RDES	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.4671154287073671	[139]	[109,104,156,89]	-7	hSpCas9	negative selection	8444953
57748608	57748631	12	+	27260156	RDES	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-1.0624542630571832	[418]	[254,223,216,209]	-9	hSpCas9	negative selection	8499284
57748614	57748637	12	+	27260156	RDES	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.10280362218730926	[374]	[461,450,480,440]	1	hSpCas9	negative selection	8499285
57748617	57748640	12	-	27260156	RDES	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.25467044873408007	[1754]	[2018,2423,2563,2678]	4	hSpCas9	negative selection	8499286
57748645	57748668	12	-	27260156	RDES	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.7535406170912451	[506]	[693,972,1115,1226]	9	hSpCas9	negative selection	8499287
57749467	57749490	12	-	27260156	RDES	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-1.042001154154685	[250]	[156,89,142,171]	-9	hSpCas9	negative selection	8509229
57750922	57750945	12	+	27260156	RDES	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.5687242911258085	[312]	[176,229,322,253]	-7	hSpCas9	negative selection	8509230
57750751	57750774	12	-	27260156	RDES	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-1.0560111507525236	[763]	[302,457,381,579]	-9	hSpCas9	negative selection	8509231
57751025	57751048	12	+	27260156	PC3	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.2564716387726931	[1486]	[1038,1051,1755,1259]	-5	hSpCas9	negative selection	8566202
57751296	57751319	12	+	27260156	PC3	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.07341936986926645	[1390]	[1103,1194,2410,1501]	1	hSpCas9	negative selection	8566203
57751206	57751229	12	-	27260156	PC3	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.012652355260108772	[139]	[94,99,337,113]	0	hSpCas9	negative selection	8566204
57748608	57748631	12	+	27260156	PC3	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	0.07200240262761204	[418]	[255,422,629,567]	1	hSpCas9	negative selection	8620535
57748614	57748637	12	+	27260156	PC3	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.34956871688034097	[374]	[290,458,678,596]	7	hSpCas9	negative selection	8620536
57748617	57748640	12	-	27260156	PC3	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.48889473048132404	[1754]	[1666,2288,4585,2195]	8	hSpCas9	negative selection	8620537
57748645	57748668	12	-	27260156	PC3	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.45326536015905666	[506]	[453,617,1303,667]	8	hSpCas9	negative selection	8620538
57749467	57749490	12	-	27260156	PC3	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	0.22079655538646592	[250]	[131,260,545,380]	5	hSpCas9	negative selection	8630480
57750922	57750945	12	+	27260156	PC3	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.10754664796339808	[312]	[180,292,534,262]	-2	hSpCas9	negative selection	8630481
57750751	57750774	12	-	27260156	PC3	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.43545146579437144	[763]	[295,455,1273,581]	-7	hSpCas9	negative selection	8630482
57751025	57751048	12	+	27260156	PATU8988T	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.05246131149657107	[1486]	[1098,1416,1438,1606]	-1	hSpCas9	negative selection	8687453
57751296	57751319	12	+	27260156	PATU8988T	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.41667873376698084	[1390]	[1633,1852,1708,2003]	7	hSpCas9	negative selection	8687454
57751206	57751229	12	-	27260156	PATU8988T	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.3710215339023186	[139]	[146,161,145,249]	6	hSpCas9	negative selection	8687455
57748608	57748631	12	+	27260156	PATU8988T	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.0727925364413009	[418]	[342,377,387,433]	-1	hSpCas9	negative selection	8741786
57748614	57748637	12	+	27260156	PATU8988T	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.6606119224427206	[374]	[473,306,629,878]	9	hSpCas9	negative selection	8741787
57748617	57748640	12	-	27260156	PATU8988T	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.22100720178713518	[1754]	[1831,2065,1965,2056]	4	hSpCas9	negative selection	8741788
57748645	57748668	12	-	27260156	PATU8988T	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.8571075510183723	[506]	[735,1084,873,871]	9	hSpCas9	negative selection	8741789
57749467	57749490	12	-	27260156	PATU8988T	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.6673512583031433	[250]	[274,50,100,176]	-8	hSpCas9	negative selection	8751731
57750922	57750945	12	+	27260156	PATU8988T	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	0.16086737314069732	[312]	[399,240,275,434]	2	hSpCas9	negative selection	8751732
57750751	57750774	12	-	27260156	PATU8988T	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.2002593726381251	[763]	[568,778,647,581]	-3	hSpCas9	negative selection	8751733
57751025	57751048	12	+	27260156	T47D	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.4930194325769237	[1486]	[1082,1260,1263,1313]	-8	hSpCas9	negative selection	8808704
57751296	57751319	12	+	27260156	T47D	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	-0.29711883094223857	[1390]	[1436,1172,1290,1389]	-6	hSpCas9	negative selection	8808705
57751206	57751229	12	-	27260156	T47D	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.7638372255981398	[139]	[151,57,80,96]	-9	hSpCas9	negative selection	8808706
57748608	57748631	12	+	27260156	T47D	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	0.05712913781700542	[418]	[519,493,437,583]	1	hSpCas9	negative selection	8863037
57748614	57748637	12	+	27260156	T47D	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.3543886755307838	[374]	[593,518,592,529]	7	hSpCas9	negative selection	8863038
57748617	57748640	12	-	27260156	T47D	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.4355932933189459	[1754]	[2751,2574,2775,2979]	8	hSpCas9	negative selection	8863039
57748645	57748668	12	-	27260156	T47D	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.6616321227414452	[506]	[1018,856,813,1059]	9	hSpCas9	negative selection	8863040
57749467	57749490	12	-	27260156	T47D	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.13546957354501932	[250]	[241,274,211,337]	-3	hSpCas9	negative selection	8872982
57750922	57750945	12	+	27260156	T47D	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.816002245353335	[312]	[193,186,252,194]	-9	hSpCas9	negative selection	8872983
57750751	57750774	12	-	27260156	T47D	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.7377523448558674	[763]	[581,528,532,489]	-9	hSpCas9	negative selection	8872984
57751025	57751048	12	+	27260156	SU8686	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.237060910275237	[1486]	[1106,1105,1334,1528]	-4	hSpCas9	negative selection	8929955
57751296	57751319	12	+	27260156	SU8686	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.3840399632878788	[1390]	[1608,1504,2152,2024]	6	hSpCas9	negative selection	8929956
57751206	57751229	12	-	27260156	SU8686	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.24792610217647892	[139]	[112,99,145,109]	-4	hSpCas9	negative selection	8929957
57748608	57748631	12	+	27260156	SU8686	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.19918979164955355	[418]	[271,364,328,511]	-3	hSpCas9	negative selection	8984288
57748614	57748637	12	+	27260156	SU8686	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.31741332461847604	[374]	[415,321,643,502]	5	hSpCas9	negative selection	8984289
57748617	57748640	12	-	27260156	SU8686	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.3928888328590521	[1754]	[2090,1903,2695,2557]	6	hSpCas9	negative selection	8984290
57748645	57748668	12	-	27260156	SU8686	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.7549159896307818	[506]	[708,924,801,975]	9	hSpCas9	negative selection	8984291
57749467	57749490	12	-	27260156	SU8686	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.5875505887050791	[250]	[160,147,187,167]	-7	hSpCas9	negative selection	8994233
57750922	57750945	12	+	27260156	SU8686	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.46888808091459067	[312]	[206,207,212,279]	-6	hSpCas9	negative selection	8994234
57750751	57750774	12	-	27260156	SU8686	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.23074161092912726	[763]	[543,599,624,859]	-4	hSpCas9	negative selection	8994235
57751025	57751048	12	+	27260156	SKES1	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.8745833582978223	[1486]	[898,782,874,692]	-9	hSpCas9	negative selection	9051206
57751296	57751319	12	+	27260156	SKES1	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	-0.12160260043477478	[1390]	[1359,1408,1286,1082]	-3	hSpCas9	negative selection	9051207
57751206	57751229	12	-	27260156	SKES1	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.5770822173796191	[139]	[100,81,95,93]	-8	hSpCas9	negative selection	9051208
57748608	57748631	12	+	27260156	SKES1	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.29356317390586106	[418]	[229,409,424,292]	-6	hSpCas9	negative selection	9105539
57748614	57748637	12	+	27260156	SKES1	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.2738703133230181	[374]	[597,495,368,376]	6	hSpCas9	negative selection	9105540
57748617	57748640	12	-	27260156	SKES1	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.3899505633570315	[1754]	[2669,2408,2292,1893]	7	hSpCas9	negative selection	9105541
57748645	57748668	12	-	27260156	SKES1	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.5969014323358095	[506]	[890,765,817,611]	9	hSpCas9	negative selection	9105542
57749467	57749490	12	-	27260156	SKES1	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.4183093117419079	[250]	[153,206,164,215]	-7	hSpCas9	negative selection	9115484
57750922	57750945	12	+	27260156	SKES1	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.5861001932250695	[312]	[172,281,209,172]	-8	hSpCas9	negative selection	9115485
57750751	57750774	12	-	27260156	SKES1	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.680157921309	[763]	[362,429,443,621]	-9	hSpCas9	negative selection	9115486
57751025	57751048	12	+	27260156	TOV112D	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	0.08727602314675997	[1486]	[1665,2054,1199,1529]	1	hSpCas9	negative selection	9172457
57751296	57751319	12	+	27260156	TOV112D	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.407310617315334	[1390]	[1733,2179,2145,1411]	7	hSpCas9	negative selection	9172458
57751206	57751229	12	-	27260156	TOV112D	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	0.4507902011503493	[139]	[225,177,140,219]	8	hSpCas9	negative selection	9172459
57748608	57748631	12	+	27260156	TOV112D	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	0.17498141402419015	[418]	[601,498,398,412]	3	hSpCas9	negative selection	9226790
57748614	57748637	12	+	27260156	TOV112D	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.29485059445951745	[374]	[511,630,449,299]	5	hSpCas9	negative selection	9226791
57748617	57748640	12	-	27260156	TOV112D	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.6576476813559582	[1754]	[3042,3834,2559,1955]	9	hSpCas9	negative selection	9226792
57748645	57748668	12	-	27260156	TOV112D	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.7689934189868739	[506]	[689,1495,539,873]	9	hSpCas9	negative selection	9226793
57749467	57749490	12	-	27260156	TOV112D	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.20480864749640348	[250]	[104,184,402,162]	-4	hSpCas9	negative selection	9236735
57750922	57750945	12	+	27260156	TOV112D	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	0.45197995128746793	[312]	[427,527,320,460]	8	hSpCas9	negative selection	9236736
57750751	57750774	12	-	27260156	TOV112D	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	0.09803040206891434	[763]	[757,906,621,998]	2	hSpCas9	negative selection	9236737
57751025	57751048	12	+	27260156	TC71	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.5103032520094881	[1486]	[1100,990,1250,1129]	-8	hSpCas9	negative selection	9293708
57751296	57751319	12	+	27260156	TC71	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	0.07607804775881744	[1390]	[1677,1366,1571,1673]	2	hSpCas9	negative selection	9293709
57751206	57751229	12	-	27260156	TC71	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.2408609857982731	[139]	[106,124,115,162]	-6	hSpCas9	negative selection	9293710
57748608	57748631	12	+	27260156	TC71	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.039909294168614357	[418]	[487,410,482,357]	-1	hSpCas9	negative selection	9348041
57748614	57748637	12	+	27260156	TC71	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.30492276978292493	[374]	[374,498,595,516]	7	hSpCas9	negative selection	9348042
57748617	57748640	12	-	27260156	TC71	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.34890977503080256	[1754]	[2279,2572,2508,2208]	8	hSpCas9	negative selection	9348043
57748645	57748668	12	-	27260156	TC71	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.6097658111872328	[506]	[831,776,893,810]	9	hSpCas9	negative selection	9348044
57749467	57749490	12	-	27260156	TC71	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.23922875876979766	[250]	[222,204,224,260]	-6	hSpCas9	negative selection	9357986
57750922	57750945	12	+	27260156	TC71	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.25286452786324787	[312]	[233,265,296,332]	-6	hSpCas9	negative selection	9357987
57750751	57750774	12	-	27260156	TC71	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.32411165791093915	[763]	[585,699,591,747]	-7	hSpCas9	negative selection	9357988
57751025	57751048	12	+	27260156	TC32	viability	ATCTCGGTGAACGATGCAATTGG	CDK4	ENSG00000135446	-0.5991020116692973	[1486]	[822,738,956,1219]	-8	hSpCas9	negative selection	9414959
57751296	57751319	12	+	27260156	TC32	viability	CCTTGATCTCCCGGTCAGTTCGG	CDK4	ENSG00000135446	-0.35366133843366243	[1390]	[814,753,1327,1334]	-6	hSpCas9	negative selection	9414960
57751206	57751229	12	-	27260156	TC32	viability	CTTGCCAGCCGAAACGATCAAGG	CDK4	ENSG00000135446	-0.3986029341574686	[139]	[103,55,126,128]	-6	hSpCas9	negative selection	9414961
57748608	57748631	12	+	27260156	TC32	viability	TCAGCATTTCCTGAGGGGAGAGG	CDK4	ENSG00000135446	-0.4173787156257226	[418]	[227,137,463,439]	-7	hSpCas9	negative selection	9469292
57748614	57748637	12	+	27260156	TC32	viability	TTTCCTGAGGGGAGAGGCAAAGG	CDK4	ENSG00000135446	0.05747447377266229	[374]	[339,271,457,433]	1	hSpCas9	negative selection	9469293
57748617	57748640	12	-	27260156	TC32	viability	TGACCTTTGCCTCTCCCCTCAGG	CDK4	ENSG00000135446	0.44073239364381056	[1754]	[2195,1758,2970,2202]	7	hSpCas9	negative selection	9469294
57748645	57748668	12	-	27260156	TC32	viability	GCAGAAGTCTGTTTTCTTCATGG	CDK4	ENSG00000135446	0.8383450878468812	[506]	[758,663,1091,972]	9	hSpCas9	negative selection	9469295
57749467	57749490	12	-	27260156	TC32	viability	AAACTCTGAAGCCGACCAGTTGG	CDK4	ENSG00000135446	-0.4153280924271816	[250]	[127,192,230,151]	-7	hSpCas9	negative selection	9479237
57750922	57750945	12	+	27260156	TC32	viability	CCACGGGTGTAAGTGCCATCTGG	CDK4	ENSG00000135446	-0.20372955567618833	[312]	[229,171,395,268]	-4	hSpCas9	negative selection	9479238
57750751	57750774	12	-	27260156	TC32	viability	CCCTTTAGGTTGTTACACTCTGG	CDK4	ENSG00000135446	-0.5395161516396975	[763]	[432,430,524,598]	-8	hSpCas9	negative selection	9479239
57748558	57748581	12	+	27869803	HPAFII	viability after 27 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-1.9078190988618453	[254]	[68,7,NaN]	-8	hSpCas9	negative selection	9547977
57749218	57749241	12	+	27869803	HPAFII	viability after 27 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-0.08202780060866893	[314]	[276,55,NaN]	0	hSpCas9	negative selection	9547978
57750686	57750709	12	+	27869803	HPAFII	viability after 27 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-4.050961117688124	[363]	[16,6,NaN]	-9	hSpCas9	negative selection	9547979
57750922	57750945	12	-	27869803	HPAFII	viability after 27 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-1.5971494191821187	[982]	[160,178,NaN]	-7	hSpCas9	negative selection	9547980
57751202	57751225	12	+	27869803	HPAFII	viability after 27 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.8904632300776187	[350]	[170,39,NaN]	-6	hSpCas9	negative selection	9547981
57751528	57751551	12	-	27869803	HPAFII	viability after 27 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-3.2790850938816263	[93]	[9,0,NaN]	-9	hSpCas9	negative selection	9547982
57748558	57748581	12	+	27869803	HPAFII	viability after 15 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-1.2035742175051258	[254]	[237,44,NaN]	-8	hSpCas9	negative selection	9630426
57749218	57749241	12	+	27869803	HPAFII	viability after 15 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-0.4016000449014696	[314]	[579,54,NaN]	-4	hSpCas9	negative selection	9630427
57750686	57750709	12	+	27869803	HPAFII	viability after 15 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-1.8119209844488369	[363]	[132,97,NaN]	-9	hSpCas9	negative selection	9630428
57750922	57750945	12	-	27869803	HPAFII	viability after 15 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.5811040386209096	[982]	[802,645,NaN]	-6	hSpCas9	negative selection	9630429
57751202	57751225	12	+	27869803	HPAFII	viability after 15 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-0.5777594343559119	[350]	[380,172,NaN]	-6	hSpCas9	negative selection	9630430
57751528	57751551	12	-	27869803	HPAFII	viability after 15 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-3.0999666445155416	[93]	[4,15,NaN]	-9	hSpCas9	negative selection	9630431
57748558	57748581	12	+	27869803	ASPC1	viability after 36 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-0.759800674177556	[610]	[194,32,149]	-6	hSpCas9	negative selection	9712875
57749218	57749241	12	+	27869803	ASPC1	viability after 36 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	0.4140864856635154	[647]	[845,123,56]	4	hSpCas9	negative selection	9712876
57750686	57750709	12	+	27869803	ASPC1	viability after 36 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-1.1682710208006541	[1023]	[116,139,201]	-8	hSpCas9	negative selection	9712877
57750922	57750945	12	-	27869803	ASPC1	viability after 36 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-1.1566578466987383	[2577]	[152,340,624]	-8	hSpCas9	negative selection	9712878
57751202	57751225	12	+	27869803	ASPC1	viability after 36 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	0.31298280400642836	[804]	[323,270,424]	3	hSpCas9	negative selection	9712879
57751528	57751551	12	-	27869803	ASPC1	viability after 36 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-0.043546551557863244	[223]	[251,10,2]	0	hSpCas9	negative selection	9712880
57748558	57748581	12	+	27869803	PATU8988S	viability after 35 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-0.8159529327078413	[591]	[106,163,NaN]	-7	hSpCas9	negative selection	9795324
57749218	57749241	12	+	27869803	PATU8988S	viability after 35 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-0.7128291653302183	[722]	[247,106,NaN]	-6	hSpCas9	negative selection	9795325
57750686	57750709	12	+	27869803	PATU8988S	viability after 35 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	0.3577173726012053	[968]	[536,462,NaN]	4	hSpCas9	negative selection	9795326
57750922	57750945	12	-	27869803	PATU8988S	viability after 35 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	0.5416288353174292	[2492]	[1907,1012,NaN]	6	hSpCas9	negative selection	9795327
57751202	57751225	12	+	27869803	PATU8988S	viability after 35 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	0.742755680206951	[609]	[458,362,NaN]	7	hSpCas9	negative selection	9795328
57751528	57751551	12	-	27869803	PATU8988S	viability after 35 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.44525548583222885	[175]	[101,90,NaN]	5	hSpCas9	negative selection	9795329
57748558	57748581	12	+	27869803	PATU8988S	viability after 31 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-0.17290603737719695	[591]	[182,242,NaN]	-2	hSpCas9	negative selection	9877773
57749218	57749241	12	+	27869803	PATU8988S	viability after 31 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-0.9549192217591915	[722]	[153,141,NaN]	-7	hSpCas9	negative selection	9877774
57750686	57750709	12	+	27869803	PATU8988S	viability after 31 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	0.37261161346141747	[968]	[534,455,NaN]	4	hSpCas9	negative selection	9877775
57750922	57750945	12	-	27869803	PATU8988S	viability after 31 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	0.49167953622616833	[2492]	[1490,1278,NaN]	6	hSpCas9	negative selection	9877776
57751202	57751225	12	+	27869803	PATU8988S	viability after 31 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	0.6661825176815761	[609]	[286,511,NaN]	7	hSpCas9	negative selection	9877777
57751528	57751551	12	-	27869803	PATU8988S	viability after 31 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	0.5839891501875778	[175]	[91,121,NaN]	7	hSpCas9	negative selection	9877778
57748558	57748581	12	+	27869803	HPAFII	viability after 35 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-2.063043706588108	[254]	[52,5,NaN]	-8	hSpCas9	negative selection	9960222
57749218	57749241	12	+	27869803	HPAFII	viability after 35 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-0.8383138819850642	[314]	[115,58,NaN]	-5	hSpCas9	negative selection	9960223
57750686	57750709	12	+	27869803	HPAFII	viability after 35 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-4.097718394852535	[363]	[6,14,NaN]	-9	hSpCas9	negative selection	9960224
57750922	57750945	12	-	27869803	HPAFII	viability after 35 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-1.5737531265517293	[982]	[161,172,NaN]	-7	hSpCas9	negative selection	9960225
57751202	57751225	12	+	27869803	HPAFII	viability after 35 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-1.5269738333652225	[350]	[87,31,NaN]	-7	hSpCas9	negative selection	9960226
57751528	57751551	12	-	27869803	HPAFII	viability after 35 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-5.572500298680962	[93]	[0,0,NaN]	-9	hSpCas9	negative selection	9960227
57748558	57748581	12	+	27869803	HPAFII	viability after 31 days	AGAGTGCTGCAGAGCTCGAAAGG	CDK4	ENSG00000135446	-1.6518293401380952	[254]	[79,7,NaN]	-7	hSpCas9	negative selection	10042671
57749218	57749241	12	+	27869803	HPAFII	viability after 31 days	TACCACCGACTGCACTGGGCGGG	CDK4	ENSG00000135446	-1.2705173455672722	[314]	[112,29,NaN]	-6	hSpCas9	negative selection	10042672
57750686	57750709	12	+	27869803	HPAFII	viability after 31 days	CCAACACTCCACATGTCCACAGG	CDK4	ENSG00000135446	-4.410316000024419	[363]	[11,6,NaN]	-9	hSpCas9	negative selection	10042673
57750922	57750945	12	-	27869803	HPAFII	viability after 31 days	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-1.7113162744650388	[982]	[111,229,NaN]	-7	hSpCas9	negative selection	10042674
57751202	57751225	12	+	27869803	HPAFII	viability after 31 days	CTCACCTTGATCGTTTCGGCTGG	CDK4	ENSG00000135446	-1.7353013642650439	[350]	[73,42,NaN]	-7	hSpCas9	negative selection	10042675
57751528	57751551	12	-	27869803	HPAFII	viability after 31 days	GGTGGCTTTACTGAGGCGACTGG	CDK4	ENSG00000135446	-5.721217652002379	[93]	[0,0,NaN]	-9	hSpCas9	negative selection	10042676
57751632	57751655	12	-	28162770	P31FUJ	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	-0.8473089807495502	[443]	[289]	-6	hSpCas9	negative selection	10130703
57750937	57750960	12	-	28162770	P31FUJ	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	-0.5864391590290793	[114]	[89]	-5	hSpCas9	negative selection	10130704
57750922	57750945	12	-	28162770	P31FUJ	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.03903046101769858	[159]	[182]	0	hSpCas9	negative selection	10130705
57749217	57749240	12	+	28162770	P31FUJ	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	0.21952252772865843	[295]	[404]	2	hSpCas9	negative selection	10130706
57751618	57751641	12	+	28162770	P31FUJ	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	0.09840370406099463	[61]	[77]	1	hSpCas9	negative selection	10130707
57751593	57751616	12	-	28162770	P31FUJ	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	0.04156020722092779	[147]	[178]	0	hSpCas9	negative selection	10130708
57751581	57751604	12	-	28162770	P31FUJ	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	0.2549916372997796	[86]	[121]	2	hSpCas9	negative selection	10130709
57751546	57751569	12	-	28162770	P31FUJ	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	0.04687595753928697	[789]	[958]	0	hSpCas9	negative selection	10130710
57751242	57751265	12	-	28162770	P31FUJ	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	0.3690094809989979	[453]	[688]	4	hSpCas9	negative selection	10130711
57751214	57751237	12	+	28162770	P31FUJ	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	0.22882585469927652	[357]	[492]	2	hSpCas9	negative selection	10130712
57751632	57751655	12	-	28162770	TF1	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	NaN	[NaN]	[426]	1	hSpCas9	negative selection	10300069
57750937	57750960	12	-	28162770	TF1	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	NaN	[NaN]	[33]	1	hSpCas9	negative selection	10300070
57750922	57750945	12	-	28162770	TF1	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	NaN	[NaN]	[99]	1	hSpCas9	negative selection	10300071
57749217	57749240	12	+	28162770	TF1	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	NaN	[NaN]	[355]	1	hSpCas9	negative selection	10300072
57751618	57751641	12	+	28162770	TF1	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	NaN	[NaN]	[55]	1	hSpCas9	negative selection	10300073
57751593	57751616	12	-	28162770	TF1	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	NaN	[NaN]	[88]	1	hSpCas9	negative selection	10300074
57751581	57751604	12	-	28162770	TF1	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	NaN	[NaN]	[63]	1	hSpCas9	negative selection	10300075
57751546	57751569	12	-	28162770	TF1	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	NaN	[NaN]	[720]	1	hSpCas9	negative selection	10300076
57751242	57751265	12	-	28162770	TF1	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	NaN	[NaN]	[378]	1	hSpCas9	negative selection	10300077
57751214	57751237	12	+	28162770	TF1	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	NaN	[NaN]	[303]	1	hSpCas9	negative selection	10300078
57751632	57751655	12	-	28162770	SKM1	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	-0.060161435216769976	[114]	[194]	0	hSpCas9	negative selection	10469435
57750937	57750960	12	-	28162770	SKM1	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	-0.0009718390673247868	[29]	[52]	0	hSpCas9	negative selection	10469436
57750922	57750945	12	-	28162770	SKM1	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.07784060245159546	[39]	[66]	0	hSpCas9	negative selection	10469437
57749217	57749240	12	+	28162770	SKM1	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	0.07212966687117162	[105]	[196]	0	hSpCas9	negative selection	10469438
57751618	57751641	12	+	28162770	SKM1	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	1.444784842672896	[15]	[76]	9	hSpCas9	negative selection	10469439
57751593	57751616	12	-	28162770	SKM1	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	-0.6486700951364437	[46]	[52]	-5	hSpCas9	negative selection	10469440
57751581	57751604	12	-	28162770	SKM1	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	-0.26560834949762	[16]	[24]	-2	hSpCas9	negative selection	10469441
57751546	57751569	12	-	28162770	SKM1	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	0.6794758171960691	[165]	[469]	6	hSpCas9	negative selection	10469442
57751242	57751265	12	-	28162770	SKM1	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	0.8184559152908544	[67]	[211]	7	hSpCas9	negative selection	10469443
57751214	57751237	12	+	28162770	SKM1	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	-0.13394570433674588	[71]	[115]	-1	hSpCas9	negative selection	10469444
57751632	57751655	12	-	28162770	SKM1	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	-0.060161435216769976	[114]	[194]	0	hSpCas9	negative selection	10638801
57750937	57750960	12	-	28162770	SKM1	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	-0.0009718390673247868	[29]	[52]	0	hSpCas9	negative selection	10638802
57750922	57750945	12	-	28162770	SKM1	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.07784060245159546	[39]	[66]	0	hSpCas9	negative selection	10638803
57749217	57749240	12	+	28162770	SKM1	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	0.07212966687117162	[105]	[196]	0	hSpCas9	negative selection	10638804
57751618	57751641	12	+	28162770	SKM1	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	1.444784842672896	[15]	[76]	9	hSpCas9	negative selection	10638805
57751593	57751616	12	-	28162770	SKM1	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	-0.6486700951364437	[46]	[52]	-5	hSpCas9	negative selection	10638806
57751581	57751604	12	-	28162770	SKM1	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	-0.26560834949762	[16]	[24]	-2	hSpCas9	negative selection	10638807
57751546	57751569	12	-	28162770	SKM1	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	0.6794758171960691	[165]	[469]	6	hSpCas9	negative selection	10638808
57751242	57751265	12	-	28162770	SKM1	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	0.8184559152908544	[67]	[211]	7	hSpCas9	negative selection	10638809
57751214	57751237	12	+	28162770	SKM1	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	-0.13394570433674588	[71]	[115]	-1	hSpCas9	negative selection	10638810
57751632	57751655	12	-	28162770	PL21	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	0.24673230879309171	[456]	[235]	2	hSpCas9	negative selection	10808167
57750937	57750960	12	-	28162770	PL21	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	-0.948252225403351	[132]	[29]	-6	hSpCas9	negative selection	10808168
57750922	57750945	12	-	28162770	PL21	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.2523725902081864	[155]	[56]	-2	hSpCas9	negative selection	10808169
57749217	57749240	12	+	28162770	PL21	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	-0.00572108295723972	[375]	[162]	0	hSpCas9	negative selection	10808170
57751618	57751641	12	+	28162770	PL21	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	0.8015902379990454	[28]	[21]	7	hSpCas9	negative selection	10808171
57751593	57751616	12	-	28162770	PL21	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	0.6151771137681639	[134]	[89]	5	hSpCas9	negative selection	10808172
57751581	57751604	12	-	28162770	PL21	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	0.6576123800885606	[66]	[45]	5	hSpCas9	negative selection	10808173
57751546	57751569	12	-	28162770	PL21	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	0.14288229688011955	[513]	[246]	1	hSpCas9	negative selection	10808174
57751242	57751265	12	-	28162770	PL21	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	0.6073997631764448	[278]	[184]	5	hSpCas9	negative selection	10808175
57751214	57751237	12	+	28162770	PL21	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	-1.029342231633447	[271]	[57]	-6	hSpCas9	negative selection	10808176
57751632	57751655	12	-	28162770	P31FUJ	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	-0.8473089807495502	[443]	[289]	-6	hSpCas9	negative selection	10977533
57750937	57750960	12	-	28162770	P31FUJ	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	-0.5864391590290793	[114]	[89]	-5	hSpCas9	negative selection	10977534
57750922	57750945	12	-	28162770	P31FUJ	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.03903046101769858	[159]	[182]	0	hSpCas9	negative selection	10977535
57749217	57749240	12	+	28162770	P31FUJ	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	0.21952252772865843	[295]	[404]	2	hSpCas9	negative selection	10977536
57751618	57751641	12	+	28162770	P31FUJ	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	0.09840370406099463	[61]	[77]	1	hSpCas9	negative selection	10977537
57751593	57751616	12	-	28162770	P31FUJ	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	0.04156020722092779	[147]	[178]	0	hSpCas9	negative selection	10977538
57751581	57751604	12	-	28162770	P31FUJ	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	0.2549916372997796	[86]	[121]	2	hSpCas9	negative selection	10977539
57751546	57751569	12	-	28162770	P31FUJ	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	0.04687595753928697	[789]	[958]	0	hSpCas9	negative selection	10977540
57751242	57751265	12	-	28162770	P31FUJ	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	0.3690094809989979	[453]	[688]	4	hSpCas9	negative selection	10977541
57751214	57751237	12	+	28162770	P31FUJ	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	0.22882585469927652	[357]	[492]	2	hSpCas9	negative selection	10977542
57751632	57751655	12	-	28162770	OCIAML5	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	-0.37987200030479074	[265]	[368]	-3	hSpCas9	negative selection	11146899
57750937	57750960	12	-	28162770	OCIAML5	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	-0.2773724055966678	[93]	[139]	-2	hSpCas9	negative selection	11146900
57750922	57750945	12	-	28162770	OCIAML5	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	0.3617127201677427	[71]	[166]	3	hSpCas9	negative selection	11146901
57749217	57749240	12	+	28162770	OCIAML5	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	0.41382748910903755	[167]	[403]	3	hSpCas9	negative selection	11146902
57751618	57751641	12	+	28162770	OCIAML5	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	0.7328959298571589	[13]	[41]	6	hSpCas9	negative selection	11146903
57751593	57751616	12	-	28162770	OCIAML5	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	0.1236858828893258	[59]	[117]	1	hSpCas9	negative selection	11146904
57751581	57751604	12	-	28162770	OCIAML5	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	-0.8210396752433726	[91]	[93]	-5	hSpCas9	negative selection	11146905
57751546	57751569	12	-	28162770	OCIAML5	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	-0.2217121673288267	[364]	[564]	-2	hSpCas9	negative selection	11146906
57751242	57751265	12	-	28162770	OCIAML5	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	-0.4416018013749772	[236]	[314]	-3	hSpCas9	negative selection	11146907
57751214	57751237	12	+	28162770	OCIAML5	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	0.13483777152431986	[165]	[328]	1	hSpCas9	negative selection	11146908
57751632	57751655	12	-	28162770	EOL1	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	-0.668276846923592	[919]	[304]	-5	hSpCas9	negative selection	11316265
57750937	57750960	12	-	28162770	EOL1	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	-1.4395057989895041	[138]	[26]	-7	hSpCas9	negative selection	11316266
57750922	57750945	12	-	28162770	EOL1	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.13082898546583893	[238]	[114]	-1	hSpCas9	negative selection	11316267
57749217	57749240	12	+	28162770	EOL1	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	-0.2664804788565781	[636]	[278]	-2	hSpCas9	negative selection	11316268
57751618	57751641	12	+	28162770	EOL1	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	-0.7635082221147251	[86]	[26]	-5	hSpCas9	negative selection	11316269
57751593	57751616	12	-	28162770	EOL1	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	-0.4494270710864231	[253]	[97]	-3	hSpCas9	negative selection	11316270
57751581	57751604	12	-	28162770	EOL1	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	-0.4765505367504357	[102]	[38]	-4	hSpCas9	negative selection	11316271
57751546	57751569	12	-	28162770	EOL1	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	-0.18116166960058044	[735]	[341]	-1	hSpCas9	negative selection	11316272
57751242	57751265	12	-	28162770	EOL1	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	0.9676164934624205	[362]	[373]	8	hSpCas9	negative selection	11316273
57751214	57751237	12	+	28162770	EOL1	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	-0.22200089178240742	[351]	[158]	-2	hSpCas9	negative selection	11316274
57751632	57751655	12	-	28162770	MOLM13	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	0.3992855675455551	[645]	[615]	3	hSpCas9	negative selection	11485631
57750937	57750960	12	-	28162770	MOLM13	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	-0.42722404628758626	[304]	[163]	-3	hSpCas9	negative selection	11485632
57750922	57750945	12	-	28162770	MOLM13	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	0.4059616324013769	[237]	[227]	3	hSpCas9	negative selection	11485633
57749217	57749240	12	+	28162770	MOLM13	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	-0.0504020795312895	[443]	[309]	0	hSpCas9	negative selection	11485634
57751618	57751641	12	+	28162770	MOLM13	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	1.467889381544579	[32]	[65]	9	hSpCas9	negative selection	11485635
57751593	57751616	12	-	28162770	MOLM13	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	1.5895188259461097	[107]	[234]	9	hSpCas9	negative selection	11485636
57751581	57751604	12	-	28162770	MOLM13	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	-1.3394655405130251	[132]	[37]	-6	hSpCas9	negative selection	11485637
57751546	57751569	12	-	28162770	MOLM13	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	-0.6860107470730687	[760]	[341]	-4	hSpCas9	negative selection	11485638
57751242	57751265	12	-	28162770	MOLM13	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	0.5399533411282309	[409]	[430]	4	hSpCas9	negative selection	11485639
57751214	57751237	12	+	28162770	MOLM13	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	-0.49872444996087445	[298]	[152]	-3	hSpCas9	negative selection	11485640
57751632	57751655	12	-	28162770	HEL	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	0.0471290870796921	[611]	[404]	0	hSpCas9	negative selection	11654997
57750937	57750960	12	-	28162770	HEL	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	-1.363361367536061	[236]	[58]	-7	hSpCas9	negative selection	11654998
57750922	57750945	12	-	28162770	HEL	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	0.2147854448362277	[186]	[138]	1	hSpCas9	negative selection	11654999
57749217	57749240	12	+	28162770	HEL	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	0.32262659014175477	[396]	[317]	2	hSpCas9	negative selection	11655000
57751618	57751641	12	+	28162770	HEL	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	1.865131253336805	[50]	[118]	9	hSpCas9	negative selection	11655001
57751593	57751616	12	-	28162770	HEL	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	-0.19080002186090228	[138]	[77]	-1	hSpCas9	negative selection	11655002
57751581	57751604	12	-	28162770	HEL	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	-1.8254100037380496	[82]	[14]	-7	hSpCas9	negative selection	11655003
57751546	57751569	12	-	28162770	HEL	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	-1.3098140055971828	[657]	[169]	-6	hSpCas9	negative selection	11655004
57751242	57751265	12	-	28162770	HEL	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	-0.5867430141224104	[339]	[144]	-4	hSpCas9	negative selection	11655005
57751214	57751237	12	+	28162770	HEL	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	0.0901978089715782	[307]	[209]	0	hSpCas9	negative selection	11655006
57751632	57751655	12	-	28162770	MV411	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	0.13409607770683052	[449]	[415]	1	hSpCas9	negative selection	11824363
57750937	57750960	12	-	28162770	MV411	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	-0.14302192577540274	[96]	[73]	-1	hSpCas9	negative selection	11824364
57750922	57750945	12	-	28162770	MV411	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	0.5315809832106673	[146]	[178]	5	hSpCas9	negative selection	11824365
57749217	57749240	12	+	28162770	MV411	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	0.29271843008364185	[344]	[355]	2	hSpCas9	negative selection	11824366
57751618	57751641	12	+	28162770	MV411	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	-0.9308996904757376	[42]	[18]	-6	hSpCas9	negative selection	11824367
57751593	57751616	12	-	28162770	MV411	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	1.0388509289713581	[103]	[179]	8	hSpCas9	negative selection	11824368
57751581	57751604	12	-	28162770	MV411	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	-2.659453044825743	[44]	[5]	-9	hSpCas9	negative selection	11824369
57751546	57751569	12	-	28162770	MV411	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	-0.11135583785644942	[544]	[424]	-1	hSpCas9	negative selection	11824370
57751242	57751265	12	-	28162770	MV411	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	-0.2439508346261834	[290]	[206]	-2	hSpCas9	negative selection	11824371
57751214	57751237	12	+	28162770	MV411	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	0.04964916956441978	[280]	[244]	0	hSpCas9	negative selection	11824372
57751632	57751655	12	-	28162770	MONOMAC1	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	-0.38002314060349673	[318]	[280]	-3	hSpCas9	negative selection	11993729
57750937	57750960	12	-	28162770	MONOMAC1	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	0.31516931122628833	[60]	[86]	3	hSpCas9	negative selection	11993730
57750922	57750945	12	-	28162770	MONOMAC1	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	0.01945497283721004	[104]	[121]	0	hSpCas9	negative selection	11993731
57749217	57749240	12	+	28162770	MONOMAC1	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	-0.3507462624550068	[187]	[168]	-3	hSpCas9	negative selection	11993732
57751618	57751641	12	+	28162770	MONOMAC1	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	-1.7330897472997635	[28]	[9]	-8	hSpCas9	negative selection	11993733
57751593	57751616	12	-	28162770	MONOMAC1	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	0.30819846119086847	[61]	[87]	3	hSpCas9	negative selection	11993734
57751581	57751604	12	-	28162770	MONOMAC1	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	-1.78199934778071	[65]	[21]	-8	hSpCas9	negative selection	11993735
57751546	57751569	12	-	28162770	MONOMAC1	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	-0.1797069685216366	[330]	[334]	-1	hSpCas9	negative selection	11993736
57751242	57751265	12	-	28162770	MONOMAC1	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	-0.3513649934508476	[206]	[185]	-3	hSpCas9	negative selection	11993737
57751214	57751237	12	+	28162770	MONOMAC1	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	-0.8058460897350775	[182]	[119]	-6	hSpCas9	negative selection	11993738
57751632	57751655	12	-	28162770	OCIAML2	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	-0.4225971288203598	[95]	[396]	-3	hSpCas9	negative selection	12163095
57750937	57750960	12	-	28162770	OCIAML2	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	-0.9470678691851484	[23]	[68]	-6	hSpCas9	negative selection	12163096
57750922	57750945	12	-	28162770	OCIAML2	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	-0.5961607073260201	[20]	[76]	-4	hSpCas9	negative selection	12163097
57749217	57749240	12	+	28162770	OCIAML2	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	0.39673240617971994	[73]	[539]	4	hSpCas9	negative selection	12163098
57751618	57751641	12	+	28162770	OCIAML2	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	0.7881044431580069	[6]	[66]	7	hSpCas9	negative selection	12163099
57751593	57751616	12	-	28162770	OCIAML2	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	-0.5341949540196276	[28]	[110]	-4	hSpCas9	negative selection	12163100
57751581	57751604	12	-	28162770	OCIAML2	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	0.07956725731831815	[13]	[81]	0	hSpCas9	negative selection	12163101
57751546	57751569	12	-	28162770	OCIAML2	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	-0.8955151104773522	[97]	[291]	-6	hSpCas9	negative selection	12163102
57751242	57751265	12	-	28162770	OCIAML2	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	0.17213712700185735	[52]	[330]	1	hSpCas9	negative selection	12163103
57751214	57751237	12	+	28162770	OCIAML2	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	-0.3938142281913304	[31]	[134]	-3	hSpCas9	negative selection	12163104
57751632	57751655	12	-	28162770	OCIAML3	viability	AAGGCCCGTGATCCCCACAGTGG	CDK4	ENSG00000135446	-0.7238450779667446	[121]	[222]	-5	hSpCas9	negative selection	12332461
57750937	57750960	12	-	28162770	OCIAML3	viability	CAGAATCTACAGCTACCAGATGG	CDK4	ENSG00000135446	-1.371615218987715	[29]	[34]	-7	hSpCas9	negative selection	12332462
57750922	57750945	12	-	28162770	OCIAML3	viability	CCAGATGGCACTTACACCCGTGG	CDK4	ENSG00000135446	0.37684601401632034	[24]	[97]	3	hSpCas9	negative selection	12332463
57749217	57749240	12	+	28162770	OCIAML3	viability	GTACCACCGACTGCACTGGGCGG	CDK4	ENSG00000135446	-1.7009228442406752	[97]	[90]	-8	hSpCas9	negative selection	12332464
57751618	57751641	12	+	28162770	OCIAML3	viability	GGGCCACAAAGTGGCCACTGTGG	CDK4	ENSG00000135446	0.06895737239826616	[17]	[56]	0	hSpCas9	negative selection	12332465
57751593	57751616	12	-	28162770	OCIAML3	viability	AAGAGTGTGAGAGTCCCCAATGG	CDK4	ENSG00000135446	-2.1383281565479733	[34]	[23]	-8	hSpCas9	negative selection	12332466
57751581	57751604	12	-	28162770	OCIAML3	viability	GTCCCCAATGGAGGAGGAGGTGG	CDK4	ENSG00000135446	-1.3460801268805778	[15]	[18]	-7	hSpCas9	negative selection	12332467
57751546	57751569	12	-	28162770	OCIAML3	viability	CATCAGCACAGTTCGTGAGGTGG	CDK4	ENSG00000135446	-0.8991274475249718	[159]	[258]	-6	hSpCas9	negative selection	12332468
57751242	57751265	12	-	28162770	OCIAML3	viability	CCTAAGGACATATCTGGACAAGG	CDK4	ENSG00000135446	-1.0183229531910178	[103]	[154]	-6	hSpCas9	negative selection	12332469
57751214	57751237	12	+	28162770	OCIAML3	viability	GTTTCGGCTGGCAAGCCTGGTGG	CDK4	ENSG00000135446	-1.5351139512705947	[95]	[99]	-8	hSpCas9	negative selection	12332470