| 49094466 | 49094489 | 12 | + | 26472758 | Jiyoye | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | -0.45264696044586605 | [48] | [26] | -3 | hSpCas9 | negative selection | 43776 | 49094442 | 49094465 | 12 | - | 26472758 | Jiyoye | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | 1.441122713429211 | [62] | [128] | 8 | hSpCas9 | negative selection | 43777 | 49094398 | 49094421 | 12 | + | 26472758 | Jiyoye | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | -0.41284595238789135 | [142] | [80] | -3 | hSpCas9 | negative selection | 43778 | 49094492 | 49094515 | 12 | + | 26472758 | Jiyoye | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | 0.059252078085566554 | [111] | [87] | 0 | hSpCas9 | negative selection | 43779 | 49094340 | 49094363 | 12 | - | 26472758 | Jiyoye | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 1.020152258396626 | [33] | [51] | 6 | hSpCas9 | negative selection | 43780 | 49094314 | 49094337 | 12 | - | 26472758 | Jiyoye | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | -1.055167832551327 | [371] | [134] | -6 | hSpCas9 | negative selection | 43781 | 49094466 | 49094489 | 12 | + | 26472758 | KBM7 | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | 0.5624540650503169 | [242,231] | [196,136] | 6 | hSpCas9 | negative selection | 234894 | 49094442 | 49094465 | 12 | - | 26472758 | KBM7 | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | -0.13082796750506004 | [828,494] | [375,190] | -1 | hSpCas9 | negative selection | 234895 | 49094398 | 49094421 | 12 | + | 26472758 | KBM7 | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 0.3764709951813929 | [369,219] | [161,188] | 4 | hSpCas9 | negative selection | 234896 | 49094492 | 49094515 | 12 | + | 26472758 | KBM7 | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | 0.5446877815645329 | [444,440] | [282,324] | 6 | hSpCas9 | negative selection | 234897 | 49094340 | 49094363 | 12 | - | 26472758 | KBM7 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 1.1804610582355857 | [253,226] | [216,290] | 9 | hSpCas9 | negative selection | 234898 | 49094314 | 49094337 | 12 | - | 26472758 | KBM7 | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | -0.015981505447207223 | [696,704] | [341,314] | 0 | hSpCas9 | negative selection | 234899 | 49094466 | 49094489 | 12 | + | 26472758 | Raji | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | 0.9057496742039488 | [68] | [29] | 8 | hSpCas9 | negative selection | 426012 | 49094442 | 49094465 | 12 | - | 26472758 | Raji | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | -0.037006373961575134 | [251] | [56] | 0 | hSpCas9 | negative selection | 426013 | 49094398 | 49094421 | 12 | + | 26472758 | Raji | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 0.6923460360947558 | [111] | [41] | 6 | hSpCas9 | negative selection | 426014 | 49094492 | 49094515 | 12 | + | 26472758 | Raji | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | -0.029279011936964583 | [342] | [77] | 0 | hSpCas9 | negative selection | 426015 | 49094340 | 49094363 | 12 | - | 26472758 | Raji | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 0.9995802458390844 | [124] | [57] | 8 | hSpCas9 | negative selection | 426016 | 49094314 | 49094337 | 12 | - | 26472758 | Raji | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | -0.2478817433878754 | [393] | [76] | -2 | hSpCas9 | negative selection | 426017 | 49094466 | 49094489 | 12 | + | 26472758 | K562 | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | -0.3181759600262546 | [191] | [129] | -2 | hSpCas9 | negative selection | 617130 | 49094442 | 49094465 | 12 | - | 26472758 | K562 | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | 0.3282224841405825 | [417] | [442] | 2 | hSpCas9 | negative selection | 617131 | 49094398 | 49094421 | 12 | + | 26472758 | K562 | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 0.4752562172591516 | [218] | [256] | 4 | hSpCas9 | negative selection | 617132 | 49094492 | 49094515 | 12 | + | 26472758 | K562 | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | 0.42774815530540233 | [368] | [418] | 3 | hSpCas9 | negative selection | 617133 | 49094340 | 49094363 | 12 | - | 26472758 | K562 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 1.0607067744940586 | [183] | [323] | 8 | hSpCas9 | negative selection | 617134 | 49094314 | 49094337 | 12 | - | 26472758 | K562 | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | 0.08247882324012934 | [517] | [462] | 0 | hSpCas9 | negative selection | 617135 | 49094348 | 49094371 | 12 | - | 26627737 | DLD1 | viability | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | -0.19917200469565866 | [1035] | [270,201,357] | -2 | hSpCas9 | negative selection | 783938 | 49094464 | 49094487 | 12 | + | 26627737 | DLD1 | viability | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | -0.2848006270934623 | [843] | [245,212,193] | -3 | hSpCas9 | negative selection | 783939 | 49094348 | 49094371 | 12 | - | 26627737 | GBM cells | viability after 5 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.34925093698720977 | [433] | [352,239] | 5 | hSpCas9 | negative selection | 866253 | 49094464 | 49094487 | 12 | + | 26627737 | GBM cells | viability after 5 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 0.06468005234433016 | [385] | [246,185] | 1 | hSpCas9 | negative selection | 866254 | 49094348 | 49094371 | 12 | - | 26627737 | GBM cells | viability after 13 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.41628706843155217 | [433] | [316,311] | 5 | hSpCas9 | negative selection | 948568 | 49094464 | 49094487 | 12 | + | 26627737 | GBM cells | viability after 13 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | -0.3864381789367032 | [385] | [189,135] | -4 | hSpCas9 | negative selection | 948569 | 49094348 | 49094371 | 12 | - | 26627737 | GBM cells | viability after 21 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.7554677836941021 | [433] | [396,398] | 7 | hSpCas9 | negative selection | 1030883 | 49094464 | 49094487 | 12 | + | 26627737 | GBM cells | viability after 21 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | -0.35878281470333845 | [385] | [150,174] | -3 | hSpCas9 | negative selection | 1030884 | 49094348 | 49094371 | 12 | - | 26627737 | RPE1 | viability after 9 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 1.064066057182092 | [998] | [673,627] | 6 | hSpCas9 | negative selection | 1113198 | 49094464 | 49094487 | 12 | + | 26627737 | RPE1 | viability after 9 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | -0.3808959253846764 | [2251] | [478,621] | -3 | hSpCas9 | negative selection | 1113199 | 49094348 | 49094371 | 12 | - | 26627737 | RPE1 | viability after 12 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 1.2183613073996913 | [998] | [675,569] | 7 | hSpCas9 | negative selection | 1195513 | 49094464 | 49094487 | 12 | + | 26627737 | RPE1 | viability after 12 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | -0.485705977621538 | [2251] | [485,374] | -3 | hSpCas9 | negative selection | 1195514 | 49094348 | 49094371 | 12 | - | 26627737 | RPE1 | viability after 15 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 1.547516617864089 | [998] | [934,720] | 8 | hSpCas9 | negative selection | 1277828 | 49094464 | 49094487 | 12 | + | 26627737 | RPE1 | viability after 15 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | -0.6184241565879346 | [2251] | [332,493] | -4 | hSpCas9 | negative selection | 1277829 | 49094348 | 49094371 | 12 | - | 26627737 | RPE1 | viability after 18 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 1.215761230436823 | [998] | [747,495] | 7 | hSpCas9 | negative selection | 1360143 | 49094464 | 49094487 | 12 | + | 26627737 | RPE1 | viability after 18 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 0.16182674336401615 | [2251] | [661,698] | 1 | hSpCas9 | negative selection | 1360144 | 49094348 | 49094371 | 12 | - | 26627737 | HeLa | viability after 8 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.5191872213954427 | [647] | [542,356,346] | 4 | hSpCas9 | negative selection | 1442458 | 49094464 | 49094487 | 12 | + | 26627737 | HeLa | viability after 8 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 0.3774636042271744 | [425] | [161,330,213] | 3 | hSpCas9 | negative selection | 1442459 | 49094348 | 49094371 | 12 | - | 26627737 | HeLa | viability after 12 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.49785062500517085 | [647] | [364,378,389] | 4 | hSpCas9 | negative selection | 1524773 | 49094464 | 49094487 | 12 | + | 26627737 | HeLa | viability after 12 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 0.46363225392461976 | [425] | [229,298,192] | 4 | hSpCas9 | negative selection | 1524774 | 49094348 | 49094371 | 12 | - | 26627737 | HeLa | viability after 15 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.0545753444065884 | [647] | [251,189,388] | 0 | hSpCas9 | negative selection | 1607088 | 49094464 | 49094487 | 12 | + | 26627737 | HeLa | viability after 15 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 1.3653622826055085 | [425] | [722,213,395] | 8 | hSpCas9 | negative selection | 1607089 | 49094348 | 49094371 | 12 | - | 26627737 | HeLa | viability after 18 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.07141332683347623 | [647] | [169,163,388] | 0 | hSpCas9 | negative selection | 1689403 | 49094464 | 49094487 | 12 | + | 26627737 | HeLa | viability after 18 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 1.3145681267429452 | [425] | [459,170,395] | 8 | hSpCas9 | negative selection | 1689404 | 49094348 | 49094371 | 12 | - | 26627737 | HCT116 | viability after 6 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | -1.9052950948837342 | [1485] | [140,18] | -8 | hSpCas9 | negative selection | 1771718 | 49094464 | 49094487 | 12 | + | 26627737 | HCT116 | viability after 6 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 0.4949910052678277 | [836] | [207,172] | 2 | hSpCas9 | negative selection | 1771719 | 49094348 | 49094371 | 12 | - | 26627737 | HCT116 | viability after 8 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.48825698306582366 | [554] | [475,398,412] | 5 | hSpCas9 | negative selection | 1854033 | 49094464 | 49094487 | 12 | + | 26627737 | HCT116 | viability after 8 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | -0.5271496412207961 | [625] | [234,324,158] | -6 | hSpCas9 | negative selection | 1854034 | 49094348 | 49094371 | 12 | - | 26627737 | HCT116 | viability after 9 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | -0.46614469127807767 | [1485] | [470,141] | -3 | hSpCas9 | negative selection | 1936348 | 49094464 | 49094487 | 12 | + | 26627737 | HCT116 | viability after 9 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 0.06832437715450379 | [836] | [254,217] | 0 | hSpCas9 | negative selection | 1936349 | 49094348 | 49094371 | 12 | - | 26627737 | HCT116 | viability after 12 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.13647173107482802 | [554] | [387,324,242] | 1 | hSpCas9 | negative selection | 2018663 | 49094464 | 49094487 | 12 | + | 26627737 | HCT116 | viability after 12 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | -0.2897139550327742 | [625] | [436,242,111] | -3 | hSpCas9 | negative selection | 2018664 | 49094348 | 49094371 | 12 | - | 26627737 | HCT116 | viability after 15 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.31952655432280763 | [554] | [433,475,288] | 3 | hSpCas9 | negative selection | 2100978 | 49094464 | 49094487 | 12 | + | 26627737 | HCT116 | viability after 15 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 0.18184166497043552 | [625] | [595,299,350] | 1 | hSpCas9 | negative selection | 2100979 | 49094348 | 49094371 | 12 | - | 26627737 | HCT116 | viability after 18 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.9189942295933904 | [554] | [650,473,393] | 7 | hSpCas9 | negative selection | 2183293 | 49094464 | 49094487 | 12 | + | 26627737 | HCT116 | viability after 18 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 0.48640259504662864 | [625] | [561,443,256] | 4 | hSpCas9 | negative selection | 2183294 | 49094340 | 49094363 | 12 | - | 24336569 | HL60 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 0.45627419120589896 | [1179] | [3425] | 4 | hSpCas9 | negative selection | 2260585 | 49094348 | 49094371 | 12 | - | 24336569 | HL60 | viability | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.23877564410569618 | [512] | [1280] | 2 | hSpCas9 | negative selection | 2260586 | 49094361 | 49094384 | 12 | - | 24336569 | HL60 | viability | CTCTACAAGCAATTTGTGCCCGG | DHH | ENSG00000139549 | -0.09420723115908647 | [795] | [1577] | -1 | hSpCas9 | negative selection | 2260587 | 49094367 | 49094390 | 12 | + | 24336569 | HL60 | viability | ACAAATTGCTTGTAGAGTAGCGG | DHH | ENSG00000139549 | 0.19290784913917824 | [844] | [2043] | 1 | hSpCas9 | negative selection | 2260588 | 49094392 | 49094415 | 12 | + | 24336569 | HL60 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 1.1554434098441597 | [331] | [1564] | 8 | hSpCas9 | negative selection | 2260589 | 49094398 | 49094421 | 12 | + | 24336569 | HL60 | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 0.782191218591951 | [279] | [1018] | 6 | hSpCas9 | negative selection | 2260590 | 49094406 | 49094429 | 12 | + | 24336569 | HL60 | viability | GCATAGCGGCGCCGGCCAACCGG | DHH | ENSG00000139549 | -0.3553783281942531 | [771] | [1276] | -3 | hSpCas9 | negative selection | 2260591 | 49094441 | 49094464 | 12 | - | 24336569 | HL60 | viability | CGCTGCCAGCCCAGAGCTGCGGG | DHH | ENSG00000139549 | 2.1513653036618208 | [181] | [1710] | 9 | hSpCas9 | negative selection | 2260592 | 49094464 | 49094487 | 12 | - | 24336569 | HL60 | viability | CCTGTGCTGCTTGGCACTTCTGG | DHH | ENSG00000139549 | 0.7889549383144758 | [226] | [829] | 6 | hSpCas9 | negative selection | 2260593 | 49094492 | 49094515 | 12 | + | 24336569 | HL60 | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | -1.0904866130933448 | [801] | [796] | -7 | hSpCas9 | negative selection | 2260594 | 49094340 | 49094363 | 12 | - | 24336569 | KBM7 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 1.0266455335836682 | [687] | [3822] | 8 | hSpCas9 | negative selection | 2327762 | 49094348 | 49094371 | 12 | - | 24336569 | KBM7 | viability | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | -0.14099517937714737 | [396] | [981] | -1 | hSpCas9 | negative selection | 2327763 | 49094361 | 49094384 | 12 | - | 24336569 | KBM7 | viability | CTCTACAAGCAATTTGTGCCCGG | DHH | ENSG00000139549 | 0.8092358980950822 | [493] | [2360] | 7 | hSpCas9 | negative selection | 2327764 | 49094367 | 49094390 | 12 | + | 24336569 | KBM7 | viability | ACAAATTGCTTGTAGAGTAGCGG | DHH | ENSG00000139549 | -0.3801238493158483 | [960] | [2013] | -3 | hSpCas9 | negative selection | 2327765 | 49094392 | 49094415 | 12 | + | 24336569 | KBM7 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 1.0905890926933326 | [281] | [1637] | 8 | hSpCas9 | negative selection | 2327766 | 49094398 | 49094421 | 12 | + | 24336569 | KBM7 | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 0.08420326631309871 | [174] | [505] | 0 | hSpCas9 | negative selection | 2327767 | 49094406 | 49094429 | 12 | + | 24336569 | KBM7 | viability | GCATAGCGGCGCCGGCCAACCGG | DHH | ENSG00000139549 | 0.42937411490553234 | [421] | [1549] | 4 | hSpCas9 | negative selection | 2327768 | 49094441 | 49094464 | 12 | - | 24336569 | KBM7 | viability | CGCTGCCAGCCCAGAGCTGCGGG | DHH | ENSG00000139549 | -0.12159288508716681 | [283] | [711] | -1 | hSpCas9 | negative selection | 2327769 | 49094464 | 49094487 | 12 | - | 24336569 | KBM7 | viability | CCTGTGCTGCTTGGCACTTCTGG | DHH | ENSG00000139549 | 0.2561530944345643 | [302] | [986] | 2 | hSpCas9 | negative selection | 2327770 | 49094492 | 49094515 | 12 | + | 24336569 | KBM7 | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | -1.4721886638928843 | [472] | [464] | -7 | hSpCas9 | negative selection | 2327771 | 49094368 | 49094391 | 12 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | ACAAATTGCTTGTAGAGTAGCGG | DHH | ENSG00000139549 | 0.3530621620656337 | [4,4] | [5,3] | 7 | hSpCas9 | positive selection | 2983425 | 49094467 | 49094490 | 12 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | 0.35798600111632173 | [2,2] | [3,2] | 7 | hSpCas9 | positive selection | 2983426 | 49094204 | 49094227 | 12 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | TCCTTACCTCGGTCATCAGGCGG | DHH | ENSG00000139549 | 0.04480263009354868 | [4,4] | [4,3] | 0 | hSpCas9 | positive selection | 2983427 | 49094368 | 49094391 | 12 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | ACAAATTGCTTGTAGAGTAGCGG | DHH | ENSG00000139549 | -0.4320059773762114 | [4,4] | [3,0] | -6 | hSpCas9 | positive selection | 3051283 | 49094467 | 49094490 | 12 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | -0.24223020730008848 | [2,2] | [2,0] | -4 | hSpCas9 | positive selection | 3051284 | 49094204 | 49094227 | 12 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | TCCTTACCTCGGTCATCAGGCGG | DHH | ENSG00000139549 | 0.3740945596767822 | [4,4] | [7,2] | 6 | hSpCas9 | positive selection | 3051285 | 49090066 | 49090089 | | + | 24336571 | A375 | resistance to PLX after 7 days | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.05475748801700746 | [10,12] | [12,12] | 2 | hSpCas9 | positive selection | 3109630 | 49090066 | 49090089 | | + | 24336571 | A375 | resistance to PLX after 14 days | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | -0.06349816006839534 | [14,13] | [4,6] | 0 | hSpCas9 | positive selection | 3167423 | 49090066 | 49090089 | | + | 24336571 | A375 | viability after 7 days | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | -0.023980148213594336 | [12] | [10,12] | 0 | hSpCas9 | negative selection | 3225216 | 49090066 | 49090089 | | + | 24336571 | A375 | viability after 14 days | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.24106077408505916 | [12] | [14,13] | 3 | hSpCas9 | negative selection | 3283009 | 49094392 | 49094415 | 12 | + | 27383988 | 293T | resistance to West Nile virus (flavivirus) | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.5862882097494283 | [86,116] | [0,0] | 3 | hSpCas9 | positive selection | 3346177 | 49090066 | 49090089 | 12 | + | 27383988 | 293T | resistance to West Nile virus (flavivirus) | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 1.1065170176935817 | [78,62] | [0,0] | 5 | hSpCas9 | positive selection | 3346178 | 49094209 | 49094232 | 12 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | 1.0874012100035229 | [71,71] | [0,0] | 5 | hSpCas9 | positive selection | 3365380 | 49094367 | 49094390 | 12 | + | 26780180 | HT29 | viability (Avana library 4 designs) | ACAAATTGCTTGTAGAGTAGCGG | DHH | ENSG00000139549 | -0.892584931864366 | [] | [] | -9 | hSpCas9 | negative selection | 3420188 | 49094466 | 49094489 | 12 | + | 26780180 | HT29 | viability (Avana library 4 designs) | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | 1.52372344629298 | [] | [] | 6 | hSpCas9 | negative selection | 3420189 | 49094203 | 49094226 | 12 | + | 26780180 | HT29 | viability (Avana library 4 designs) | TCCTTACCTCGGTCATCAGGCGG | DHH | ENSG00000139549 | 0.274053866428537 | [] | [] | 1 | hSpCas9 | negative selection | 3420190 | 49094466 | 49094489 | 12 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | 2.8621834818501 | [] | [] | 4 | hSpCas9 | negative selection | 3499749 | 49094203 | 49094226 | 12 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TCCTTACCTCGGTCATCAGGCGG | DHH | ENSG00000139549 | 1.77146978037571 | [] | [] | 2 | hSpCas9 | negative selection | 3499750 | 49094367 | 49094390 | 12 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | ACAAATTGCTTGTAGAGTAGCGG | DHH | ENSG00000139549 | 0.196778965809332 | [] | [] | 0 | hSpCas9 | negative selection | 3499751 | 49094232 | 49094255 | 12 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TTCAAGGATGAGGAGAACAGTGG | DHH | ENSG00000139549 | -0.882518709759132 | [] | [] | -1 | hSpCas9 | negative selection | 3499752 | 49094466 | 49094489 | 12 | + | 26780180 | A375 | viability (Avana lentiGuide) | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | 7.13280688053595 | [] | [] | 5 | hSpCas9 | negative selection | 3608408 | 49094203 | 49094226 | 12 | + | 26780180 | A375 | viability (Avana lentiGuide) | TCCTTACCTCGGTCATCAGGCGG | DHH | ENSG00000139549 | 0.325586374882986 | [] | [] | 0 | hSpCas9 | negative selection | 3608409 | 49094367 | 49094390 | 12 | + | 26780180 | A375 | viability (Avana lentiGuide) | ACAAATTGCTTGTAGAGTAGCGG | DHH | ENSG00000139549 | -1.88541962732274 | [] | [] | -3 | hSpCas9 | negative selection | 3608410 | 49094232 | 49094255 | 12 | - | 26780180 | A375 | viability (Avana lentiGuide) | TTCAAGGATGAGGAGAACAGTGG | DHH | ENSG00000139549 | -0.104491800834825 | [] | [] | 0 | hSpCas9 | negative selection | 3608411 | 49094466 | 49094489 | 12 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | 0.029872821378016716 | [4] | [4,4] | 0 | hSpCas9 | positive selection | 3717067 | 49094203 | 49094226 | 12 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TCCTTACCTCGGTCATCAGGCGG | DHH | ENSG00000139549 | 0.11107882323692406 | [5] | [6,5] | 3 | hSpCas9 | positive selection | 3717068 | 49094367 | 49094390 | 12 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | ACAAATTGCTTGTAGAGTAGCGG | DHH | ENSG00000139549 | -0.010142045381403342 | [6] | [6,5] | 0 | hSpCas9 | positive selection | 3717069 | 49094232 | 49094255 | 12 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TTCAAGGATGAGGAGAACAGTGG | DHH | ENSG00000139549 | 0.09615493341976339 | [6] | [6,6] | 2 | hSpCas9 | positive selection | 3717070 | 49094466 | 49094489 | 12 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | -0.47069054057310805 | [4] | [1,2] | -6 | hSpCas9 | positive selection | 3825674 | 49094203 | 49094226 | 12 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TCCTTACCTCGGTCATCAGGCGG | DHH | ENSG00000139549 | -0.29153277533830274 | [6] | [6,2] | -4 | hSpCas9 | positive selection | 3825675 | 49094367 | 49094390 | 12 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | ACAAATTGCTTGTAGAGTAGCGG | DHH | ENSG00000139549 | 0.2283982385868301 | [5] | [5,5] | 6 | hSpCas9 | positive selection | 3825676 | 49094232 | 49094255 | 12 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TTCAAGGATGAGGAGAACAGTGG | DHH | ENSG00000139549 | 0.23442463956435589 | [6] | [6,5] | 6 | hSpCas9 | positive selection | 3825677 | 49094209 | 49094232 | 12 | - | 26780180 | A375 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | 1.19974925597187 | [] | [] | 6 | hSpCas9 | negative selection | 3933038 | 49094392 | 49094415 | 12 | + | 26780180 | A375 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.391341780157791 | [] | [] | 0 | hSpCas9 | negative selection | 3933039 | 49090066 | 49090089 | 12 | + | 26780180 | A375 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.51695676891576 | [] | [] | 1 | hSpCas9 | negative selection | 3933040 | 49094209 | 49094232 | 12 | - | 26780180 | HT29 | viability (GeCKOv2 library) | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | 1.56957997328186 | [] | [] | 8 | hSpCas9 | negative selection | 4041004 | 49094392 | 49094415 | 12 | + | 26780180 | HT29 | viability (GeCKOv2 library) | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.73015824252482 | [] | [] | 3 | hSpCas9 | negative selection | 4041005 | 49090066 | 49090089 | 12 | + | 26780180 | HT29 | viability (GeCKOv2 library) | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 1.12212393475798 | [] | [] | 5 | hSpCas9 | negative selection | 4041006 | 49090066 | 49090089 | 12 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.001116728935096123 | [3] | [2,2] | 0 | hSpCas9 | positive selection | 4132099 | 49090066 | 49090089 | 12 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 1.2712588346741012 | [2] | [3,0,2,3] | 9 | hSpCas9 | positive selection | 4196121 | 49094392 | 49094415 | 12 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.07898667433859141 | [2] | [2,1] | 1 | hSpCas9 | positive selection | 4266799 | 49090066 | 49090089 | 12 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.43357039774786227 | [2] | [2,2] | 8 | hSpCas9 | positive selection | 4266801 | 49094209 | 49094232 | 12 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.055529910868449744 | [2] | [2,1] | -1 | hSpCas9 | positive selection | 4331070 | 49094393 | 49094415 | 12 | + | 27760321 | OCIAML3 | viability | GAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | -0.41376288169632913 | [548,542] | [251,411] | -4 | hSpCas9 | negative selection | 4394525 | 49094393 | 49094415 | 12 | + | 27760321 | OCIAML2 | viability | GAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.182764106576283 | [548,542] | [390,649] | 2 | hSpCas9 | negative selection | 4477988 | 49094393 | 49094415 | 12 | + | 27760321 | MV411 | viability | GAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | -0.25258111835696895 | [548,542] | [176,492] | -2 | hSpCas9 | negative selection | 4561451 | 49094393 | 49094415 | 12 | + | 27760321 | HL60 | viability | GAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | -0.061913915972034494 | [548,542] | [510,340] | 0 | hSpCas9 | negative selection | 4644914 | 49094393 | 49094415 | 12 | + | 27760321 | HT1080 | viability | GAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.5958636433369999 | [542,423] | [124,472] | 3 | hSpCas9 | negative selection | 4728377 | 49094393 | 49094415 | 12 | + | 27760321 | HT29 | viability after 7 days | GAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | -0.2990714068542287 | [542,423] | [610,408,509] | -4 | hSpCas9 | negative selection | 4811840 | 49094393 | 49094415 | 12 | + | 27760321 | HT29 | viability after 25 days | GAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | -0.7296863500621857 | [542,423] | [429,350,197] | -6 | hSpCas9 | negative selection | 4895303 | 49094393 | 49094415 | 12 | + | 27760321 | HT29 | viability after 22 days | GAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | -0.3766603874487412 | [542,423] | [521,345,420] | -4 | hSpCas9 | negative selection | 4978766 | 49094393 | 49094415 | 12 | + | 27760321 | HT29 | viability after 19 days | GAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | -0.18223183096281012 | [542,423] | [383,714,356] | -2 | hSpCas9 | negative selection | 5062229 | 49094393 | 49094415 | 12 | + | 27760321 | HT29 | viability after 16 days | GAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | -0.5387361869930437 | [542,423] | [494,397,234] | -5 | hSpCas9 | negative selection | 5145692 | 49094393 | 49094415 | 12 | + | 27760321 | HT29 | viability after 13 days | GAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | -0.7052811183804639 | [542,423] | [329,339,360] | -6 | hSpCas9 | negative selection | 5229155 | 49094393 | 49094415 | 12 | + | 27760321 | HT29 | viability after 10 days | GAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | -0.09698091783540069 | [542,423] | [851,510,333] | -1 | hSpCas9 | negative selection | 5312618 | 49094393 | 49094415 | 12 | + | 27760321 | MOLM13 | viability | GAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.7509248182521684 | [548,542] | [460,569] | 5 | hSpCas9 | negative selection | 5396081 | 49094318 | 49094341 | 12 | - | 27661255 | K562 | viability | GCGCCAGTGGGCCAGCGGAGGGG | DHH | ENSG00000139549 | -5.105769567769106 | [45,39] | [0,0] | -9 | dCas9-KRAB | negative selection | 5474963 | 49094340 | 49094363 | 12 | - | 27661255 | K562 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 0.15967978471621655 | [630,683] | [594,577] | 5 | dCas9-KRAB | negative selection | 5474964 | 49094392 | 49094415 | 12 | + | 27260156 | BXPC3 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.08016022110129195 | [314] | [308,278,379,442] | 1 | hSpCas9 | negative selection | 5539259 | 49090066 | 49090089 | 12 | + | 27260156 | BXPC3 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.010542982963811509 | [205] | [179,202,240,251] | 0 | hSpCas9 | negative selection | 5539261 | 49094209 | 49094232 | 12 | - | 27260156 | BXPC3 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | 0.021328474432153133 | [285] | [291,256,371,294] | 0 | hSpCas9 | negative selection | 5603530 | 49094392 | 49094415 | 12 | + | 27260156 | A673 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.33121389791633987 | [314] | [471,478,487,461] | 7 | hSpCas9 | negative selection | 5660510 | 49090066 | 49090089 | 12 | + | 27260156 | A673 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.32945673172818435 | [205] | [348,246,361,288] | 7 | hSpCas9 | negative selection | 5660512 | 49094209 | 49094232 | 12 | - | 27260156 | A673 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.15373816834765286 | [285] | [366,245,253,379] | -4 | hSpCas9 | negative selection | 5724781 | 49094392 | 49094415 | 12 | + | 27260156 | A375 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.48500499534553615 | [314] | [528,626,601,336] | 7 | hSpCas9 | negative selection | 5781761 | 49090066 | 49090089 | 12 | + | 27260156 | A375 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | -0.2794679009152121 | [205] | [176,288,226,120] | -4 | hSpCas9 | negative selection | 5781763 | 49094209 | 49094232 | 12 | - | 27260156 | A375 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.06813820040631657 | [285] | [193,243,532,293] | -1 | hSpCas9 | negative selection | 5846032 | 49094392 | 49094415 | 12 | + | 27260156 | COLO741 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.5767080387125909 | [314] | [696,642,476] | 9 | hSpCas9 | negative selection | 5903012 | 49090066 | 49090089 | 12 | + | 27260156 | COLO741 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | -0.04087340700175002 | [205] | [268,269,230] | -1 | hSpCas9 | negative selection | 5903014 | 49094209 | 49094232 | 12 | - | 27260156 | COLO741 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | 0.24512829303228795 | [285] | [404,429,458] | 5 | hSpCas9 | negative selection | 5967283 | 49094392 | 49094415 | 12 | + | 27260156 | CAL120 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.14011238745473092 | [314] | [682,247,402] | 2 | hSpCas9 | negative selection | 6024263 | 49090066 | 49090089 | 12 | + | 27260156 | CAL120 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.021679644429505984 | [205] | [286,259,237] | 0 | hSpCas9 | negative selection | 6024265 | 49094209 | 49094232 | 12 | - | 27260156 | CAL120 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.06659791033863116 | [285] | [325,334,355] | -1 | hSpCas9 | negative selection | 6088534 | 49094392 | 49094415 | 12 | + | 27260156 | CADOES1 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.5139822183826401 | [314] | [435,480,325,430] | 8 | hSpCas9 | negative selection | 6145514 | 49090066 | 49090089 | 12 | + | 27260156 | CADOES1 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.05565398996636839 | [205] | [150,118,261,266] | 1 | hSpCas9 | negative selection | 6145516 | 49094209 | 49094232 | 12 | - | 27260156 | CADOES1 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.48249326518020763 | [285] | [168,187,228,174] | -7 | hSpCas9 | negative selection | 6209785 | 49094392 | 49094415 | 12 | + | 27260156 | EWS502 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.34485893623890096 | [314] | [395,425,385,492] | 6 | hSpCas9 | negative selection | 6266765 | 49090066 | 49090089 | 12 | + | 27260156 | EWS502 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | -0.10164475033571407 | [205] | [284,86,261,171] | -2 | hSpCas9 | negative selection | 6266767 | 49094209 | 49094232 | 12 | - | 27260156 | EWS502 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.28372016094580244 | [285] | [127,358,314,199] | -5 | hSpCas9 | negative selection | 6331036 | 49094392 | 49094415 | 12 | + | 27260156 | EW8 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.19576112324607453 | [314] | [482,302,239,172] | 3 | hSpCas9 | negative selection | 6388016 | 49090066 | 49090089 | 12 | + | 27260156 | EW8 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.14547659196395557 | [205] | [101,136,216,266] | 2 | hSpCas9 | negative selection | 6388018 | 49094209 | 49094232 | 12 | - | 27260156 | EW8 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.15811897364146166 | [285] | [176,282,113,268] | -3 | hSpCas9 | negative selection | 6452287 | 49094392 | 49094415 | 12 | + | 27260156 | CORL105 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.501471102907858 | [314] | [504,493,635,470] | 8 | hSpCas9 | negative selection | 6509267 | 49090066 | 49090089 | 12 | + | 27260156 | CORL105 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.453072218987279 | [205] | [376,260,346,340] | 8 | hSpCas9 | negative selection | 6509269 | 49094209 | 49094232 | 12 | - | 27260156 | CORL105 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | 0.14686431035719083 | [285] | [419,418,346,293] | 2 | hSpCas9 | negative selection | 6573538 | 49094392 | 49094415 | 12 | + | 27260156 | HS294T | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.8892701300174155 | [314] | [169,450,123,139] | 9 | hSpCas9 | negative selection | 6630518 | 49090066 | 49090089 | 12 | + | 27260156 | HS294T | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.09059930920141412 | [205] | [48,127,83,78] | 1 | hSpCas9 | negative selection | 6630520 | 49094209 | 49094232 | 12 | - | 27260156 | HS294T | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.7072956224075821 | [285] | [42,95,65,66] | -7 | hSpCas9 | negative selection | 6694789 | 49094392 | 49094415 | 12 | + | 27260156 | HCC44 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.4949500008675154 | [314] | [695,438,424,458] | 7 | hSpCas9 | negative selection | 6751769 | 49090066 | 49090089 | 12 | + | 27260156 | HCC44 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.12470837409601865 | [205] | [232,207,201,362] | 2 | hSpCas9 | negative selection | 6751771 | 49094209 | 49094232 | 12 | - | 27260156 | HCC44 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.30619116873117114 | [285] | [248,246,324,235] | -5 | hSpCas9 | negative selection | 6816040 | 49094392 | 49094415 | 12 | + | 27260156 | G402 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.11682962328118679 | [314] | [351,324,369,594] | 1 | hSpCas9 | negative selection | 6873020 | 49090066 | 49090089 | 12 | + | 27260156 | G402 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | -0.034818603149964655 | [205] | [233,243,174,321] | 0 | hSpCas9 | negative selection | 6873022 | 49094209 | 49094232 | 12 | - | 27260156 | G402 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.9057555927446217 | [285] | [148,186,152,246] | -8 | hSpCas9 | negative selection | 6937291 | 49094392 | 49094415 | 12 | + | 27260156 | L33 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.3603104545217348 | [314] | [352,157,301,399] | 7 | hSpCas9 | negative selection | 6994271 | 49090066 | 49090089 | 12 | + | 27260156 | L33 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.4827680440698975 | [205] | [250,145,156,294] | 8 | hSpCas9 | negative selection | 6994273 | 49094209 | 49094232 | 12 | - | 27260156 | L33 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.47791815111370184 | [285] | [224,88,117,190] | -8 | hSpCas9 | negative selection | 7058542 | 49094392 | 49094415 | 12 | + | 27260156 | K562 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.21063668473956432 | [314] | [336,419,201,337] | 2 | hSpCas9 | negative selection | 7115522 | 49090066 | 49090089 | 12 | + | 27260156 | K562 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.07559302084780195 | [205] | [341,335,64,61] | 0 | hSpCas9 | negative selection | 7115524 | 49094209 | 49094232 | 12 | - | 27260156 | K562 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.7384217412942864 | [285] | [99,110,120,256] | -7 | hSpCas9 | negative selection | 7179793 | 49094392 | 49094415 | 12 | + | 27260156 | HT29 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.31878769323160444 | [314] | [371,501,567,460] | 6 | hSpCas9 | negative selection | 7236773 | 49090066 | 49090089 | 12 | + | 27260156 | HT29 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | -0.008046961381257267 | [205] | [203,240,285,257] | 0 | hSpCas9 | negative selection | 7236775 | 49094209 | 49094232 | 12 | - | 27260156 | HT29 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | 0.0901884334001376 | [285] | [347,506,327,311] | 1 | hSpCas9 | negative selection | 7301044 | 49094392 | 49094415 | 12 | + | 27260156 | MHHES1 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.18183784946123077 | [314] | [529,347,441,311] | 3 | hSpCas9 | negative selection | 7358024 | 49090066 | 49090089 | 12 | + | 27260156 | MHHES1 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.5559383631230923 | [205] | [180,232,518,383] | 8 | hSpCas9 | negative selection | 7358026 | 49094209 | 49094232 | 12 | - | 27260156 | MHHES1 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.41542552356815676 | [285] | [350,307,147,185] | -7 | hSpCas9 | negative selection | 7422295 | 49094392 | 49094415 | 12 | + | 27260156 | MEWO | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.2886178933684318 | [314] | [366,398,314] | 6 | hSpCas9 | negative selection | 7479275 | 49090066 | 49090089 | 12 | + | 27260156 | MEWO | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.1504248760310929 | [205] | [230,209,203] | 3 | hSpCas9 | negative selection | 7479277 | 49094209 | 49094232 | 12 | - | 27260156 | MEWO | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | 0.24635317365352077 | [285] | [423,268,279] | 5 | hSpCas9 | negative selection | 7543546 | 49094392 | 49094415 | 12 | + | 27260156 | LNCAPCLONEFGC | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.1815419345483581 | [314] | [200,387,381,329] | 3 | hSpCas9 | negative selection | 7600526 | 49090066 | 49090089 | 12 | + | 27260156 | LNCAPCLONEFGC | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.39528415369578096 | [205] | [182,264,329,215] | 6 | hSpCas9 | negative selection | 7600528 | 49094209 | 49094232 | 12 | - | 27260156 | LNCAPCLONEFGC | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.01555688963261459 | [285] | [270,192,357,221] | 0 | hSpCas9 | negative selection | 7664797 | 49094392 | 49094415 | 12 | + | 27260156 | PANC0327 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.7286266165507815 | [314] | [548,467,442,400] | 9 | hSpCas9 | negative selection | 7721777 | 49090066 | 49090089 | 12 | + | 27260156 | PANC0327 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.1493691510849795 | [205] | [154,269,124,248] | 2 | hSpCas9 | negative selection | 7721779 | 49094209 | 49094232 | 12 | - | 27260156 | PANC0327 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.8050070381928174 | [285] | [97,174,192,107] | -8 | hSpCas9 | negative selection | 7786048 | 49094392 | 49094415 | 12 | + | 27260156 | NCIH2009 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.4952494468869469 | [314] | [1046,473,425] | 6 | hSpCas9 | negative selection | 7843028 | 49090066 | 49090089 | 12 | + | 27260156 | NCIH2009 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | -0.08764495049804966 | [205] | [241,181,383] | -1 | hSpCas9 | negative selection | 7843030 | 49094209 | 49094232 | 12 | - | 27260156 | NCIH2009 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.6667232521951063 | [285] | [330,272,165] | -7 | hSpCas9 | negative selection | 7907299 | 49094392 | 49094415 | 12 | + | 27260156 | NCIH1373 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.45392267897516575 | [314] | [527,289,703,112] | 4 | hSpCas9 | negative selection | 7964279 | 49090066 | 49090089 | 12 | + | 27260156 | NCIH1373 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.23899445208917391 | [205] | [204,410,55,105] | 2 | hSpCas9 | negative selection | 7964281 | 49094209 | 49094232 | 12 | - | 27260156 | NCIH1373 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.752054255346492 | [285] | [177,432,33,21] | -6 | hSpCas9 | negative selection | 8028550 | 49094392 | 49094415 | 12 | + | 27260156 | PATU8902 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.7267940590104134 | [314] | [1240,672,525,472] | 7 | hSpCas9 | negative selection | 8085530 | 49090066 | 49090089 | 12 | + | 27260156 | PATU8902 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | -0.03170656932019966 | [205] | [157,477,239,253] | 0 | hSpCas9 | negative selection | 8085532 | 49094209 | 49094232 | 12 | - | 27260156 | PATU8902 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | 0.035480200587193145 | [285] | [471,230,500,398] | 0 | hSpCas9 | negative selection | 8149801 | 49094392 | 49094415 | 12 | + | 27260156 | PANC1 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.5584820455836647 | [314] | [397,610,285,343] | 8 | hSpCas9 | negative selection | 8206781 | 49090066 | 49090089 | 12 | + | 27260156 | PANC1 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.6756173978667459 | [205] | [167,506,329,185] | 9 | hSpCas9 | negative selection | 8206783 | 49094209 | 49094232 | 12 | - | 27260156 | PANC1 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.07240871354262146 | [285] | [243,177,222,267] | -1 | hSpCas9 | negative selection | 8271052 | 49094392 | 49094415 | 12 | + | 27260156 | PANC0813 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.2951523027866173 | [314] | [488,450,537,346] | 5 | hSpCas9 | negative selection | 8328032 | 49090066 | 49090089 | 12 | + | 27260156 | PANC0813 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.5357885964038465 | [205] | [464,195,306,439] | 8 | hSpCas9 | negative selection | 8328034 | 49094209 | 49094232 | 12 | - | 27260156 | PANC0813 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.2796620938539107 | [285] | [439,181,386,121] | -4 | hSpCas9 | negative selection | 8392303 | 49094392 | 49094415 | 12 | + | 27260156 | RDES | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | -0.01029681514525671 | [314] | [327,398,414,276] | 0 | hSpCas9 | negative selection | 8449283 | 49090066 | 49090089 | 12 | + | 27260156 | RDES | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | -0.15361724474017913 | [205] | [241,240,169,173] | -3 | hSpCas9 | negative selection | 8449285 | 49094209 | 49094232 | 12 | - | 27260156 | RDES | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | 0.028086719634204727 | [285] | [251,274,492,342] | 0 | hSpCas9 | negative selection | 8513554 | 49094392 | 49094415 | 12 | + | 27260156 | PC3 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.12696100445940278 | [314] | [166,256,588,517] | 3 | hSpCas9 | negative selection | 8570534 | 49090066 | 49090089 | 12 | + | 27260156 | PC3 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | -0.30326069362304753 | [205] | [96,200,164,216] | -6 | hSpCas9 | negative selection | 8570536 | 49094209 | 49094232 | 12 | - | 27260156 | PC3 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | 0.3051056660909953 | [285] | [224,500,544,217] | 6 | hSpCas9 | negative selection | 8634805 | 49094392 | 49094415 | 12 | + | 27260156 | PATU8988T | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.37131571823042786 | [314] | [367,400,336,476] | 6 | hSpCas9 | negative selection | 8691785 | 49090066 | 49090089 | 12 | + | 27260156 | PATU8988T | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.702188636342554 | [205] | [447,314,288,235] | 9 | hSpCas9 | negative selection | 8691787 | 49094209 | 49094232 | 12 | - | 27260156 | PATU8988T | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.5673532521450513 | [285] | [224,189,153,176] | -7 | hSpCas9 | negative selection | 8756056 | 49094392 | 49094415 | 12 | + | 27260156 | T47D | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.28813777199259405 | [314] | [452,464,447,423] | 6 | hSpCas9 | negative selection | 8813036 | 49090066 | 49090089 | 12 | + | 27260156 | T47D | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.04579134929047868 | [205] | [221,255,217,295] | 1 | hSpCas9 | negative selection | 8813038 | 49094209 | 49094232 | 12 | - | 27260156 | T47D | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.3005785541382435 | [285] | [318,258,270,232] | -6 | hSpCas9 | negative selection | 8877307 | 49094392 | 49094415 | 12 | + | 27260156 | SU8686 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.3579182099881784 | [314] | [420,403,338,434] | 6 | hSpCas9 | negative selection | 8934287 | 49090066 | 49090089 | 12 | + | 27260156 | SU8686 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.0812181289707199 | [205] | [189,276,169,219] | 1 | hSpCas9 | negative selection | 8934289 | 49094209 | 49094232 | 12 | - | 27260156 | SU8686 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.44169100830910923 | [285] | [206,190,214,225] | -6 | hSpCas9 | negative selection | 8998558 | 49094392 | 49094415 | 12 | + | 27260156 | SKES1 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | -0.035040212131006276 | [314] | [354,331,228,316] | 0 | hSpCas9 | negative selection | 9055538 | 49090066 | 49090089 | 12 | + | 27260156 | SKES1 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | -0.04844113715362597 | [205] | [212,219,189,176] | -1 | hSpCas9 | negative selection | 9055540 | 49094209 | 49094232 | 12 | - | 27260156 | SKES1 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | 0.1634985218865901 | [285] | [370,453,277,208] | 3 | hSpCas9 | negative selection | 9119809 | 49094392 | 49094415 | 12 | + | 27260156 | TOV112D | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.2046467662162914 | [314] | [316,732,283,210] | 4 | hSpCas9 | negative selection | 9176789 | 49090066 | 49090089 | 12 | + | 27260156 | TOV112D | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | 0.09622077291653697 | [205] | [233,132,294,199] | 1 | hSpCas9 | negative selection | 9176791 | 49094209 | 49094232 | 12 | - | 27260156 | TOV112D | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.7802352294960544 | [285] | [146,229,217,87] | -9 | hSpCas9 | negative selection | 9241060 | 49094392 | 49094415 | 12 | + | 27260156 | TC71 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.40808909248192116 | [314] | [397,512,421,461] | 8 | hSpCas9 | negative selection | 9298040 | 49090066 | 49090089 | 12 | + | 27260156 | TC71 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | -0.0030181169756744453 | [205] | [166,253,239,220] | 0 | hSpCas9 | negative selection | 9298042 | 49094209 | 49094232 | 12 | - | 27260156 | TC71 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.48367362613928533 | [285] | [201,263,224,183] | -8 | hSpCas9 | negative selection | 9362311 | 49094392 | 49094415 | 12 | + | 27260156 | TC32 | viability | CGAGCTGCTTGCGCGCATAGCGG | DHH | ENSG00000139549 | 0.3538435534689074 | [314] | [315,355,536,320] | 6 | hSpCas9 | negative selection | 9419291 | 49090066 | 49090089 | 12 | + | 27260156 | TC32 | viability | GAGCGGCGCGAACACGCCCACGG | DHH | ENSG00000139549 | -0.06343415313147882 | [205] | [177,63,308,252] | -1 | hSpCas9 | negative selection | 9419293 | 49094209 | 49094232 | 12 | - | 27260156 | TC32 | viability | AGCCGACCGCCTGATGACCGAGG | DHH | ENSG00000139549 | -0.303611141439859 | [285] | [146,155,261,340] | -5 | hSpCas9 | negative selection | 9483562 | 49094348 | 49094371 | 12 | - | 27869803 | HPAFII | viability after 27 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.9542233150952784 | [516] | [608,457,NaN] | 7 | hSpCas9 | negative selection | 9546938 | 49094464 | 49094487 | 12 | + | 27869803 | HPAFII | viability after 27 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 0.7821401036816821 | [400] | [739,47,NaN] | 6 | hSpCas9 | negative selection | 9546939 | 49094348 | 49094371 | 12 | - | 27869803 | HPAFII | viability after 15 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.7290902674480686 | [516] | [1105,805,NaN] | 7 | hSpCas9 | negative selection | 9629387 | 49094464 | 49094487 | 12 | + | 27869803 | HPAFII | viability after 15 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 0.05931489791120326 | [400] | [847,200,NaN] | 0 | hSpCas9 | negative selection | 9629388 | 49094348 | 49094371 | 12 | - | 27869803 | ASPC1 | viability after 36 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | -0.05337561024420934 | [1439] | [560,270,594] | 0 | hSpCas9 | negative selection | 9711836 | 49094464 | 49094487 | 12 | + | 27869803 | ASPC1 | viability after 36 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | -0.27068083962506395 | [999] | [190,353,303] | -3 | hSpCas9 | negative selection | 9711837 | 49094348 | 49094371 | 12 | - | 27869803 | PATU8988S | viability after 35 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.49950969479402074 | [1032] | [662,512,NaN] | 5 | hSpCas9 | negative selection | 9794285 | 49094464 | 49094487 | 12 | + | 27869803 | PATU8988S | viability after 35 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 0.609559884324369 | [940] | [471,684,NaN] | 6 | hSpCas9 | negative selection | 9794286 | 49094348 | 49094371 | 12 | - | 27869803 | PATU8988S | viability after 31 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.6587725728339222 | [1032] | [677,614,NaN] | 7 | hSpCas9 | negative selection | 9876734 | 49094464 | 49094487 | 12 | + | 27869803 | PATU8988S | viability after 31 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 0.35508876335506145 | [940] | [321,680,NaN] | 4 | hSpCas9 | negative selection | 9876735 | 49094348 | 49094371 | 12 | - | 27869803 | HPAFII | viability after 35 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 1.088638943045501 | [516] | [399,732,NaN] | 7 | hSpCas9 | negative selection | 9959183 | 49094464 | 49094487 | 12 | + | 27869803 | HPAFII | viability after 35 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 1.645323726673713 | [400] | [1063,151,NaN] | 9 | hSpCas9 | negative selection | 9959184 | 49094348 | 49094371 | 12 | - | 27869803 | HPAFII | viability after 31 days | TTGTGCCCGGCGTGCCAGAGCGG | DHH | ENSG00000139549 | 0.9475844666442443 | [516] | [516,605,NaN] | 7 | hSpCas9 | negative selection | 10041632 | 49094464 | 49094487 | 12 | + | 27869803 | HPAFII | viability after 31 days | CCAGAAGTGCCAAGCAGCACAGG | DHH | ENSG00000139549 | 1.310624929755598 | [400] | [875,211,NaN] | 8 | hSpCas9 | negative selection | 10041633 | 49094466 | 49094489 | 12 | + | 28162770 | P31FUJ | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | 1.004236992886471 | [69] | [164] | 9 | hSpCas9 | negative selection | 10143869 | 49094442 | 49094465 | 12 | - | 28162770 | P31FUJ | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | 0.19698188023365176 | [218] | [294] | 2 | hSpCas9 | negative selection | 10143870 | 49094398 | 49094421 | 12 | + | 28162770 | P31FUJ | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 0.6151947021405711 | [84] | [152] | 7 | hSpCas9 | negative selection | 10143871 | 49094492 | 49094515 | 12 | + | 28162770 | P31FUJ | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | 0.4076554088984812 | [237] | [370] | 4 | hSpCas9 | negative selection | 10143872 | 49094340 | 49094363 | 12 | - | 28162770 | P31FUJ | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 0.8910694537477899 | [144] | [315] | 8 | hSpCas9 | negative selection | 10143873 | 49094314 | 49094337 | 12 | - | 28162770 | P31FUJ | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | 0.3843407020559274 | [265] | [407] | 4 | hSpCas9 | negative selection | 10143874 | 49094466 | 49094489 | 12 | + | 28162770 | TF1 | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | NaN | [NaN] | [50] | 1 | hSpCas9 | negative selection | 10313235 | 49094442 | 49094465 | 12 | - | 28162770 | TF1 | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | NaN | [NaN] | [148] | 1 | hSpCas9 | negative selection | 10313236 | 49094398 | 49094421 | 12 | + | 28162770 | TF1 | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | NaN | [NaN] | [141] | 1 | hSpCas9 | negative selection | 10313237 | 49094492 | 49094515 | 12 | + | 28162770 | TF1 | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | NaN | [NaN] | [283] | 1 | hSpCas9 | negative selection | 10313238 | 49094340 | 49094363 | 12 | - | 28162770 | TF1 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | NaN | [NaN] | [140] | 1 | hSpCas9 | negative selection | 10313239 | 49094314 | 49094337 | 12 | - | 28162770 | TF1 | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | NaN | [NaN] | [303] | 1 | hSpCas9 | negative selection | 10313240 | 49094466 | 49094489 | 12 | + | 28162770 | SKM1 | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | 0.23689199103156322 | [23] | [49] | 2 | hSpCas9 | negative selection | 10482601 | 49094442 | 49094465 | 12 | - | 28162770 | SKM1 | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | 1.2276290697025949 | [49] | [206] | 9 | hSpCas9 | negative selection | 10482602 | 49094398 | 49094421 | 12 | + | 28162770 | SKM1 | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 0.6109577092541008 | [29] | [80] | 6 | hSpCas9 | negative selection | 10482603 | 49094492 | 49094515 | 12 | + | 28162770 | SKM1 | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | 0.677569311468506 | [57] | [163] | 6 | hSpCas9 | negative selection | 10482604 | 49094340 | 49094363 | 12 | - | 28162770 | SKM1 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 0.8688942474482159 | [34] | [112] | 8 | hSpCas9 | negative selection | 10482605 | 49094314 | 49094337 | 12 | - | 28162770 | SKM1 | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | 0.6224104033903517 | [78] | [214] | 6 | hSpCas9 | negative selection | 10482606 | 49094466 | 49094489 | 12 | + | 28162770 | SKM1 | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | 0.23689199103156322 | [23] | [49] | 2 | hSpCas9 | negative selection | 10651967 | 49094442 | 49094465 | 12 | - | 28162770 | SKM1 | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | 1.2276290697025949 | [49] | [206] | 9 | hSpCas9 | negative selection | 10651968 | 49094398 | 49094421 | 12 | + | 28162770 | SKM1 | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 0.6109577092541008 | [29] | [80] | 6 | hSpCas9 | negative selection | 10651969 | 49094492 | 49094515 | 12 | + | 28162770 | SKM1 | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | 0.677569311468506 | [57] | [163] | 6 | hSpCas9 | negative selection | 10651970 | 49094340 | 49094363 | 12 | - | 28162770 | SKM1 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 0.8688942474482159 | [34] | [112] | 8 | hSpCas9 | negative selection | 10651971 | 49094314 | 49094337 | 12 | - | 28162770 | SKM1 | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | 0.6224104033903517 | [78] | [214] | 6 | hSpCas9 | negative selection | 10651972 | 49094466 | 49094489 | 12 | + | 28162770 | PL21 | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | -4.486360912693899 | [102] | [1] | -9 | hSpCas9 | negative selection | 10821333 | 49094442 | 49094465 | 12 | - | 28162770 | PL21 | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | 0.9968114547797944 | [212] | [184] | 8 | hSpCas9 | negative selection | 10821334 | 49094398 | 49094421 | 12 | + | 28162770 | PL21 | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 1.9031578767321888 | [85] | [139] | 9 | hSpCas9 | negative selection | 10821335 | 49094492 | 49094515 | 12 | + | 28162770 | PL21 | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | 1.0048833230903864 | [236] | [206] | 8 | hSpCas9 | negative selection | 10821336 | 49094340 | 49094363 | 12 | - | 28162770 | PL21 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | -0.18318902506218537 | [119] | [45] | -1 | hSpCas9 | negative selection | 10821337 | 49094314 | 49094337 | 12 | - | 28162770 | PL21 | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | 0.38300367163913046 | [258] | [146] | 3 | hSpCas9 | negative selection | 10821338 | 49094466 | 49094489 | 12 | + | 28162770 | P31FUJ | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | 1.004236992886471 | [69] | [164] | 9 | hSpCas9 | negative selection | 10990699 | 49094442 | 49094465 | 12 | - | 28162770 | P31FUJ | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | 0.19698188023365176 | [218] | [294] | 2 | hSpCas9 | negative selection | 10990700 | 49094398 | 49094421 | 12 | + | 28162770 | P31FUJ | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 0.6151947021405711 | [84] | [152] | 7 | hSpCas9 | negative selection | 10990701 | 49094492 | 49094515 | 12 | + | 28162770 | P31FUJ | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | 0.4076554088984812 | [237] | [370] | 4 | hSpCas9 | negative selection | 10990702 | 49094340 | 49094363 | 12 | - | 28162770 | P31FUJ | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 0.8910694537477899 | [144] | [315] | 8 | hSpCas9 | negative selection | 10990703 | 49094314 | 49094337 | 12 | - | 28162770 | P31FUJ | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | 0.3843407020559274 | [265] | [407] | 4 | hSpCas9 | negative selection | 10990704 | 49094466 | 49094489 | 12 | + | 28162770 | OCIAML5 | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | 1.165420855864844 | [40] | [165] | 8 | hSpCas9 | negative selection | 11160065 | 49094442 | 49094465 | 12 | - | 28162770 | OCIAML5 | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | 1.1816540469800043 | [73] | [302] | 8 | hSpCas9 | negative selection | 11160066 | 49094398 | 49094421 | 12 | + | 28162770 | OCIAML5 | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 1.8552925612168858 | [31] | [208] | 9 | hSpCas9 | negative selection | 11160067 | 49094492 | 49094515 | 12 | + | 28162770 | OCIAML5 | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | -0.3240064613773178 | [180] | [260] | -2 | hSpCas9 | negative selection | 11160068 | 49094340 | 49094363 | 12 | - | 28162770 | OCIAML5 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | -0.2841775835017822 | [84] | [125] | -2 | hSpCas9 | negative selection | 11160069 | 49094314 | 49094337 | 12 | - | 28162770 | OCIAML5 | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | 0.24962882620535387 | [177] | [381] | 2 | hSpCas9 | negative selection | 11160070 | 49094466 | 49094489 | 12 | + | 28162770 | EOL1 | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | 1.9067364954540738 | [162] | [321] | 9 | hSpCas9 | negative selection | 11329431 | 49094442 | 49094465 | 12 | - | 28162770 | EOL1 | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | -0.38373771535815976 | [420] | [169] | -3 | hSpCas9 | negative selection | 11329432 | 49094398 | 49094421 | 12 | + | 28162770 | EOL1 | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | -0.25232999051354477 | [207] | [91] | -2 | hSpCas9 | negative selection | 11329433 | 49094492 | 49094515 | 12 | + | 28162770 | EOL1 | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | -0.4904897277083091 | [327] | [122] | -4 | hSpCas9 | negative selection | 11329434 | 49094340 | 49094363 | 12 | - | 28162770 | EOL1 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | -0.25022662953317343 | [148] | [65] | -2 | hSpCas9 | negative selection | 11329435 | 49094314 | 49094337 | 12 | - | 28162770 | EOL1 | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | -0.3889925378241087 | [342] | [137] | -3 | hSpCas9 | negative selection | 11329436 | 49094466 | 49094489 | 12 | + | 28162770 | MOLM13 | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | 1.2852979682661059 | [142] | [251] | 8 | hSpCas9 | negative selection | 11498797 | 49094442 | 49094465 | 12 | - | 28162770 | MOLM13 | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | 0.6147307698738499 | [251] | [278] | 4 | hSpCas9 | negative selection | 11498798 | 49094398 | 49094421 | 12 | + | 28162770 | MOLM13 | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 1.3331790726863242 | [128] | [234] | 8 | hSpCas9 | negative selection | 11498799 | 49094492 | 49094515 | 12 | + | 28162770 | MOLM13 | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | 0.12478577650737943 | [325] | [256] | 0 | hSpCas9 | negative selection | 11498800 | 49094340 | 49094363 | 12 | - | 28162770 | MOLM13 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | -0.23135654667246852 | [150] | [92] | -1 | hSpCas9 | negative selection | 11498801 | 49094314 | 49094337 | 12 | - | 28162770 | MOLM13 | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | -0.2537356664871415 | [342] | [207] | -1 | hSpCas9 | negative selection | 11498802 | 49094466 | 49094489 | 12 | + | 28162770 | HEL | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | -0.17892392674113067 | [75] | [42] | -1 | hSpCas9 | negative selection | 11668163 | 49094442 | 49094465 | 12 | - | 28162770 | HEL | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | 0.1964052022319746 | [232] | [170] | 1 | hSpCas9 | negative selection | 11668164 | 49094398 | 49094421 | 12 | + | 28162770 | HEL | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 1.219239753973317 | [113] | [169] | 9 | hSpCas9 | negative selection | 11668165 | 49094492 | 49094515 | 12 | + | 28162770 | HEL | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | 0.10822535396655861 | [280] | [193] | 0 | hSpCas9 | negative selection | 11668166 | 49094340 | 49094363 | 12 | - | 28162770 | HEL | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 1.1680583862941112 | [106] | [153] | 8 | hSpCas9 | negative selection | 11668167 | 49094314 | 49094337 | 12 | - | 28162770 | HEL | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | 0.1069239806082889 | [302] | [208] | 0 | hSpCas9 | negative selection | 11668168 | 49094466 | 49094489 | 12 | + | 28162770 | MV411 | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | 0.9770798041431228 | [78] | [130] | 8 | hSpCas9 | negative selection | 11837529 | 49094442 | 49094465 | 12 | - | 28162770 | MV411 | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | 0.10121680993173154 | [248] | [224] | 0 | hSpCas9 | negative selection | 11837530 | 49094398 | 49094421 | 12 | + | 28162770 | MV411 | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 0.6701286226050542 | [93] | [125] | 6 | hSpCas9 | negative selection | 11837531 | 49094492 | 49094515 | 12 | + | 28162770 | MV411 | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | -0.2655751080593658 | [263] | [184] | -2 | hSpCas9 | negative selection | 11837532 | 49094340 | 49094363 | 12 | - | 28162770 | MV411 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 0.9282600669114475 | [130] | [209] | 8 | hSpCas9 | negative selection | 11837533 | 49094314 | 49094337 | 12 | - | 28162770 | MV411 | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | 0.48559728797754 | [194] | [229] | 4 | hSpCas9 | negative selection | 11837534 | 49094466 | 49094489 | 12 | + | 28162770 | MONOMAC1 | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | -1.0293094013214872 | [72] | [40] | -7 | hSpCas9 | negative selection | 12006895 | 49094442 | 49094465 | 12 | - | 28162770 | MONOMAC1 | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | 0.23631253049623177 | [136] | [184] | 2 | hSpCas9 | negative selection | 12006896 | 49094398 | 49094421 | 12 | + | 28162770 | MONOMAC1 | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 0.0966943559971567 | [61] | [75] | 1 | hSpCas9 | negative selection | 12006897 | 49094492 | 49094515 | 12 | + | 28162770 | MONOMAC1 | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | 0.6554059645265885 | [143] | [259] | 6 | hSpCas9 | negative selection | 12006898 | 49094340 | 49094363 | 12 | - | 28162770 | MONOMAC1 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 0.31315788525963006 | [65] | [93] | 3 | hSpCas9 | negative selection | 12006899 | 49094314 | 49094337 | 12 | - | 28162770 | MONOMAC1 | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | 0.6783005796645559 | [150] | [276] | 6 | hSpCas9 | negative selection | 12006900 | 49094466 | 49094489 | 12 | + | 28162770 | OCIAML2 | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | -0.00030989046212781535 | [23] | [132] | 0 | hSpCas9 | negative selection | 12176261 | 49094442 | 49094465 | 12 | - | 28162770 | OCIAML2 | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | 0.2860990237454748 | [57] | [391] | 2 | hSpCas9 | negative selection | 12176262 | 49094398 | 49094421 | 12 | + | 28162770 | OCIAML2 | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | 0.1616383902573516 | [19] | [123] | 1 | hSpCas9 | negative selection | 12176263 | 49094492 | 49094515 | 12 | + | 28162770 | OCIAML2 | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | 0.2531603801763117 | [32] | [217] | 2 | hSpCas9 | negative selection | 12176264 | 49094340 | 49094363 | 12 | - | 28162770 | OCIAML2 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 0.33672509681544294 | [14] | [104] | 3 | hSpCas9 | negative selection | 12176265 | 49094314 | 49094337 | 12 | - | 28162770 | OCIAML2 | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | 0.45636834381493224 | [37] | [288] | 4 | hSpCas9 | negative selection | 12176266 | 49094466 | 49094489 | 12 | + | 28162770 | OCIAML3 | viability | AGAAGTGCCAAGCAGCACAGGGG | DHH | ENSG00000139549 | -1.8455464073201275 | [24] | [20] | -8 | hSpCas9 | negative selection | 12345627 | 49094442 | 49094465 | 12 | - | 28162770 | OCIAML3 | viability | GCGCTGCCAGCCCAGAGCTGCGG | DHH | ENSG00000139549 | 0.48913359497608266 | [58] | [249] | 4 | hSpCas9 | negative selection | 12345628 | 49094398 | 49094421 | 12 | + | 28162770 | OCIAML3 | viability | GCTTGCGCGCATAGCGGCGCCGG | DHH | ENSG00000139549 | -0.3164736647952542 | [32] | [79] | -2 | hSpCas9 | negative selection | 12345629 | 49094492 | 49094515 | 12 | + | 28162770 | OCIAML3 | viability | TAGATTGGTCAGGAGAGCCATGG | DHH | ENSG00000139549 | 0.11999680539873178 | [56] | [186] | 1 | hSpCas9 | negative selection | 12345630 | 49094340 | 49094363 | 12 | - | 28162770 | OCIAML3 | viability | GGCGTGCCAGAGCGGACCCTGGG | DHH | ENSG00000139549 | 0.47638168756723476 | [19] | [83] | 4 | hSpCas9 | negative selection | 12345631 | 49094314 | 49094337 | 12 | - | 28162770 | OCIAML3 | viability | CAGTGGGCCAGCGGAGGGGAGGG | DHH | ENSG00000139549 | -0.02553326239157594 | [87] | [260] | 0 | hSpCas9 | negative selection | 12345632 |