Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:1763
• Symbol:DNA2
• Description:DNA replication helicase/nuclease 2

DataSource: http://genomecrispr.dkfz.de/#!/results/DNA2

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
68422699	68422722	10	+	26627737	DLD1	viability	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-0.848815001412496	[479]	[129,0,110]	-7	hSpCas9	negative selection	775359
68431887	68431910	10	-	26627737	DLD1	viability	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-3.089528024397139	[907]	[71,8,19]	-9	hSpCas9	negative selection	775360
68442908	68442931	10	+	26627737	DLD1	viability	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-1.021745493743096	[339]	[97,39,22]	-7	hSpCas9	negative selection	775361
68446304	68446327	10	+	26627737	DLD1	viability	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-2.2597688742808297	[606]	[7,0,98]	-9	hSpCas9	negative selection	775362
68470108	68470131	10	-	26627737	DLD1	viability	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-0.6407130902867885	[480]	[156,99,40]	-6	hSpCas9	negative selection	775363
68471853	68471876	10	+	26627737	DLD1	viability	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.3534069525662227	[1872]	[612,443,335]	-4	hSpCas9	negative selection	775364
68422699	68422722	10	+	26627737	GBM cells	viability after 5 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-1.2165633425342506	[428]	[109,87]	-9	hSpCas9	negative selection	857674
68431887	68431910	10	-	26627737	GBM cells	viability after 5 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	0.28365277363149055	[408]	[250,282]	4	hSpCas9	negative selection	857675
68442908	68442931	10	+	26627737	GBM cells	viability after 5 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-0.09713894059765138	[364]	[223,141]	-1	hSpCas9	negative selection	857676
68446304	68446327	10	+	26627737	GBM cells	viability after 5 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-1.156795557700602	[263]	[41,84]	-9	hSpCas9	negative selection	857677
68470108	68470131	10	-	26627737	GBM cells	viability after 5 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	0.3551205631409339	[284]	[162,227]	5	hSpCas9	negative selection	857678
68471853	68471876	10	+	26627737	GBM cells	viability after 5 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.2576884531311794	[767]	[369,318]	-4	hSpCas9	negative selection	857679
68422699	68422722	10	+	26627737	GBM cells	viability after 13 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-2.2933218295574567	[428]	[52,42]	-9	hSpCas9	negative selection	939989
68431887	68431910	10	-	26627737	GBM cells	viability after 13 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-0.013748419713506821	[408]	[253,191]	0	hSpCas9	negative selection	939990
68442908	68442931	10	+	26627737	GBM cells	viability after 13 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-0.3981459664193214	[364]	[157,143]	-5	hSpCas9	negative selection	939991
68446304	68446327	10	+	26627737	GBM cells	viability after 13 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-3.67138114566954	[263]	[13,8]	-9	hSpCas9	negative selection	939992
68470108	68470131	10	-	26627737	GBM cells	viability after 13 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	0.3733671770330813	[284]	[196,202]	5	hSpCas9	negative selection	939993
68471853	68471876	10	+	26627737	GBM cells	viability after 13 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.3353803847719301	[767]	[380,288]	-4	hSpCas9	negative selection	939994
68422699	68422722	10	+	26627737	GBM cells	viability after 21 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-2.2746373561043645	[428]	[55,40]	-9	hSpCas9	negative selection	1022304
68431887	68431910	10	-	26627737	GBM cells	viability after 21 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	0.13842578367359581	[408]	[277,213]	1	hSpCas9	negative selection	1022305
68442908	68442931	10	+	26627737	GBM cells	viability after 21 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-0.3878164265698611	[364]	[161,141]	-4	hSpCas9	negative selection	1022306
68446304	68446327	10	+	26627737	GBM cells	viability after 21 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-3.60073148057128	[263]	[15,7]	-9	hSpCas9	negative selection	1022307
68470108	68470131	10	-	26627737	GBM cells	viability after 21 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	0.6148346499456671	[284]	[257,217]	6	hSpCas9	negative selection	1022308
68471853	68471876	10	+	26627737	GBM cells	viability after 21 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	0.005311877116546571	[767]	[423,413]	0	hSpCas9	negative selection	1022309
68422699	68422722	10	+	26627737	RPE1	viability after 9 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-2.2713135670260076	[555]	[32,39]	-9	hSpCas9	negative selection	1104619
68431887	68431910	10	-	26627737	RPE1	viability after 9 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-2.2238628275792744	[1087]	[61,86]	-9	hSpCas9	negative selection	1104620
68442908	68442931	10	+	26627737	RPE1	viability after 9 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-1.0768299707874527	[518]	[28,138]	-7	hSpCas9	negative selection	1104621
68446304	68446327	10	+	26627737	RPE1	viability after 9 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-3.3400310839223692	[2029]	[36,95]	-9	hSpCas9	negative selection	1104622
68470108	68470131	10	-	26627737	RPE1	viability after 9 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-0.028849725159507456	[673]	[184,234]	0	hSpCas9	negative selection	1104623
68471853	68471876	10	+	26627737	RPE1	viability after 9 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-1.9641860043688737	[4212]	[258,439]	-8	hSpCas9	negative selection	1104624
68422699	68422722	10	+	26627737	RPE1	viability after 12 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-1.82561343885877	[555]	[29,54]	-8	hSpCas9	negative selection	1186934
68431887	68431910	10	-	26627737	RPE1	viability after 12 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-3.527844152221104	[1087]	[19,30]	-9	hSpCas9	negative selection	1186935
68442908	68442931	10	+	26627737	RPE1	viability after 12 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-0.8317494778504835	[518]	[89,65]	-5	hSpCas9	negative selection	1186936
68446304	68446327	10	+	26627737	RPE1	viability after 12 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-3.151657339358955	[2029]	[73,47]	-9	hSpCas9	negative selection	1186937
68470108	68470131	10	-	26627737	RPE1	viability after 12 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-0.6133162814744801	[673]	[113,122]	-4	hSpCas9	negative selection	1186938
68471853	68471876	10	+	26627737	RPE1	viability after 12 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-2.238661057948174	[4212]	[165,317]	-8	hSpCas9	negative selection	1186939
68422699	68422722	10	+	26627737	RPE1	viability after 15 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-1.5998314712737214	[555]	[29,72]	-7	hSpCas9	negative selection	1269249
68431887	68431910	10	-	26627737	RPE1	viability after 15 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-2.055510955049911	[1087]	[99,48]	-8	hSpCas9	negative selection	1269250
68442908	68442931	10	+	26627737	RPE1	viability after 15 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-2.8169156258160664	[518]	[1,38]	-9	hSpCas9	negative selection	1269251
68446304	68446327	10	+	26627737	RPE1	viability after 15 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-4.265604635027145	[2029]	[37,21]	-9	hSpCas9	negative selection	1269252
68470108	68470131	10	-	26627737	RPE1	viability after 15 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-2.4380387319630157	[673]	[52,17]	-8	hSpCas9	negative selection	1269253
68471853	68471876	10	+	26627737	RPE1	viability after 15 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-2.06134204970388	[4212]	[198,368]	-8	hSpCas9	negative selection	1269254
68422699	68422722	10	+	26627737	RPE1	viability after 18 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-2.2990960279833113	[555]	[0,61]	-8	hSpCas9	negative selection	1351564
68431887	68431910	10	-	26627737	RPE1	viability after 18 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-1.8946198073167801	[1087]	[77,79]	-8	hSpCas9	negative selection	1351565
68442908	68442931	10	+	26627737	RPE1	viability after 18 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-1.5043694228586408	[518]	[30,68]	-7	hSpCas9	negative selection	1351566
68446304	68446327	10	+	26627737	RPE1	viability after 18 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-3.6978090978911915	[2029]	[33,50]	-9	hSpCas9	negative selection	1351567
68470108	68470131	10	-	26627737	RPE1	viability after 18 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-0.9149401087609284	[673]	[80,112]	-5	hSpCas9	negative selection	1351568
68471853	68471876	10	+	26627737	RPE1	viability after 18 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-2.993054315176041	[4212]	[107,179]	-9	hSpCas9	negative selection	1351569
68422699	68422722	10	+	26627737	HeLa	viability after 8 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-0.4747403565715107	[342]	[215,35,94]	-4	hSpCas9	negative selection	1433879
68431887	68431910	10	-	26627737	HeLa	viability after 8 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	0.11236279524869563	[726]	[505,302,258]	1	hSpCas9	negative selection	1433880
68442908	68442931	10	+	26627737	HeLa	viability after 8 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	0.31348575633189096	[248]	[178,148,88]	3	hSpCas9	negative selection	1433881
68446304	68446327	10	+	26627737	HeLa	viability after 8 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-0.5249082472698199	[157]	[48,96,0]	-5	hSpCas9	negative selection	1433882
68470108	68470131	10	-	26627737	HeLa	viability after 8 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-0.2491451686253672	[441]	[135,110,227]	-2	hSpCas9	negative selection	1433883
68471853	68471876	10	+	26627737	HeLa	viability after 8 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.1545391135848906	[944]	[490,347,300]	-1	hSpCas9	negative selection	1433884
68422699	68422722	10	+	26627737	HeLa	viability after 12 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-0.4258941630490066	[342]	[195,59,67]	-4	hSpCas9	negative selection	1516194
68431887	68431910	10	-	26627737	HeLa	viability after 12 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	0.4990513612819756	[726]	[367,265,654]	4	hSpCas9	negative selection	1516195
68442908	68442931	10	+	26627737	HeLa	viability after 12 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	0.9342702780598456	[248]	[407,83,115]	7	hSpCas9	negative selection	1516196
68446304	68446327	10	+	26627737	HeLa	viability after 12 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-0.8579038024464323	[157]	[5,37,62]	-7	hSpCas9	negative selection	1516197
68470108	68470131	10	-	26627737	HeLa	viability after 12 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-0.5755653063365254	[441]	[35,114,214]	-5	hSpCas9	negative selection	1516198
68471853	68471876	10	+	26627737	HeLa	viability after 12 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	0.11583071480222773	[944]	[569,194,532]	1	hSpCas9	negative selection	1516199
68422699	68422722	10	+	26627737	HeLa	viability after 15 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-0.5228294914161112	[342]	[110,111,65]	-4	hSpCas9	negative selection	1598509
68431887	68431910	10	-	26627737	HeLa	viability after 15 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	0.6387063258992844	[726]	[208,638,543]	5	hSpCas9	negative selection	1598510
68442908	68442931	10	+	26627737	HeLa	viability after 15 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	0.2447325798753422	[248]	[204,48,103]	2	hSpCas9	negative selection	1598511
68446304	68446327	10	+	26627737	HeLa	viability after 15 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-0.24655202984353508	[157]	[0,75,88]	-2	hSpCas9	negative selection	1598512
68470108	68470131	10	-	26627737	HeLa	viability after 15 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-1.4589936774701144	[441]	[22,58,118]	-8	hSpCas9	negative selection	1598513
68471853	68471876	10	+	26627737	HeLa	viability after 15 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.2592825041061517	[944]	[382,264,314]	-2	hSpCas9	negative selection	1598514
68422699	68422722	10	+	26627737	HeLa	viability after 18 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-0.5127037947596264	[342]	[77,89,65]	-4	hSpCas9	negative selection	1680824
68431887	68431910	10	-	26627737	HeLa	viability after 18 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	0.6436571204561872	[726]	[132,541,543]	5	hSpCas9	negative selection	1680825
68442908	68442931	10	+	26627737	HeLa	viability after 18 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	0.29087449567992285	[248]	[143,41,103]	2	hSpCas9	negative selection	1680826
68446304	68446327	10	+	26627737	HeLa	viability after 18 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-0.23043077908915643	[157]	[0,63,88]	-2	hSpCas9	negative selection	1680827
68470108	68470131	10	-	26627737	HeLa	viability after 18 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-1.4222418721382353	[441]	[16,50,118]	-8	hSpCas9	negative selection	1680828
68471853	68471876	10	+	26627737	HeLa	viability after 18 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.2950780984227749	[944]	[241,218,314]	-3	hSpCas9	negative selection	1680829
68422699	68422722	10	+	26627737	HCT116	viability after 6 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	0.6604547999986815	[950]	[283,209]	3	hSpCas9	negative selection	1763139
68431887	68431910	10	-	26627737	HCT116	viability after 6 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-0.516896419856082	[1366]	[349,39]	-3	hSpCas9	negative selection	1763140
68442908	68442931	10	+	26627737	HCT116	viability after 6 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	0.4309813366249617	[736]	[161,152]	2	hSpCas9	negative selection	1763141
68446304	68446327	10	+	26627737	HCT116	viability after 6 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-1.5599333649660505	[610]	[29,33]	-7	hSpCas9	negative selection	1763142
68470108	68470131	10	-	26627737	HCT116	viability after 6 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	0.8208980758953619	[321]	[91,87]	4	hSpCas9	negative selection	1763143
68471853	68471876	10	+	26627737	HCT116	viability after 6 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.4013024701739889	[2507]	[284,305]	-2	hSpCas9	negative selection	1763144
68422699	68422722	10	+	26627737	HCT116	viability after 8 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-3.185254113736245	[530]	[14,32,47]	-9	hSpCas9	negative selection	1845454
68431887	68431910	10	-	26627737	HCT116	viability after 8 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-0.9874134717164413	[679]	[114,207,241]	-8	hSpCas9	negative selection	1845455
68442908	68442931	10	+	26627737	HCT116	viability after 8 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-1.3727492430556643	[508]	[143,109,71]	-9	hSpCas9	negative selection	1845456
68446304	68446327	10	+	26627737	HCT116	viability after 8 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-2.727996258693395	[389]	[18,39,37]	-9	hSpCas9	negative selection	1845457
68470108	68470131	10	-	26627737	HCT116	viability after 8 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-0.8242484801255143	[434]	[100,126,176]	-7	hSpCas9	negative selection	1845458
68471853	68471876	10	+	26627737	HCT116	viability after 8 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-1.2715354619116757	[1030]	[331,165,209]	-9	hSpCas9	negative selection	1845459
68422699	68422722	10	+	26627737	HCT116	viability after 9 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-2.2911249791610904	[950]	[114,1]	-9	hSpCas9	negative selection	1927769
68431887	68431910	10	-	26627737	HCT116	viability after 9 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-0.5602342023574428	[1366]	[103,360]	-4	hSpCas9	negative selection	1927770
68442908	68442931	10	+	26627737	HCT116	viability after 9 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-0.8415363585841329	[736]	[225,17]	-5	hSpCas9	negative selection	1927771
68446304	68446327	10	+	26627737	HCT116	viability after 9 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-2.2507738864244593	[610]	[2,58]	-9	hSpCas9	negative selection	1927772
68470108	68470131	10	-	26627737	HCT116	viability after 9 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	0.7185015243549168	[321]	[279,31]	5	hSpCas9	negative selection	1927773
68471853	68471876	10	+	26627737	HCT116	viability after 9 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.9021733776929037	[2507]	[316,390]	-6	hSpCas9	negative selection	1927774
68422699	68422722	10	+	26627737	HCT116	viability after 12 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-5.634831890615154	[530]	[13,0,0]	-9	hSpCas9	negative selection	2010084
68431887	68431910	10	-	26627737	HCT116	viability after 12 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-1.0388292722612655	[679]	[223,115,175]	-8	hSpCas9	negative selection	2010085
68442908	68442931	10	+	26627737	HCT116	viability after 12 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-1.3314286094591512	[508]	[97,80,139]	-8	hSpCas9	negative selection	2010086
68446304	68446327	10	+	26627737	HCT116	viability after 12 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-3.1067499498454354	[389]	[31,37,0]	-9	hSpCas9	negative selection	2010087
68470108	68470131	10	-	26627737	HCT116	viability after 12 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-0.8968438612982521	[434]	[75,104,190]	-7	hSpCas9	negative selection	2010088
68471853	68471876	10	+	26627737	HCT116	viability after 12 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.944763694984632	[1030]	[170,398,286]	-7	hSpCas9	negative selection	2010089
68422699	68422722	10	+	26627737	HCT116	viability after 15 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-4.061238371501757	[530]	[34,16,4]	-9	hSpCas9	negative selection	2092399
68431887	68431910	10	-	26627737	HCT116	viability after 15 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-1.1665593897763644	[679]	[215,134,175]	-8	hSpCas9	negative selection	2092400
68442908	68442931	10	+	26627737	HCT116	viability after 15 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-1.3637531686630622	[508]	[146,98,98]	-8	hSpCas9	negative selection	2092401
68446304	68446327	10	+	26627737	HCT116	viability after 15 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-2.7354324470154396	[389]	[22,75,0]	-9	hSpCas9	negative selection	2092402
68470108	68470131	10	-	26627737	HCT116	viability after 15 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-0.7923233835304293	[434]	[137,150,142]	-7	hSpCas9	negative selection	2092403
68471853	68471876	10	+	26627737	HCT116	viability after 15 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.912264331653367	[1030]	[357,266,323]	-7	hSpCas9	negative selection	2092404
68422699	68422722	10	+	26627737	HCT116	viability after 18 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-5.124986242575825	[530]	[0,1,19]	-9	hSpCas9	negative selection	2174714
68431887	68431910	10	-	26627737	HCT116	viability after 18 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-1.5552178160807375	[679]	[128,49,162]	-8	hSpCas9	negative selection	2174715
68442908	68442931	10	+	26627737	HCT116	viability after 18 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-1.274835217531385	[508]	[169,82,50]	-8	hSpCas9	negative selection	2174716
68446304	68446327	10	+	26627737	HCT116	viability after 18 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-2.193159378570249	[389]	[6,103,6]	-9	hSpCas9	negative selection	2174717
68470108	68470131	10	-	26627737	HCT116	viability after 18 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-0.2839842958465522	[434]	[170,251,85]	-3	hSpCas9	negative selection	2174718
68471853	68471876	10	+	26627737	HCT116	viability after 18 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.4520378486644947	[1030]	[261,312,528]	-4	hSpCas9	negative selection	2174719
68470093	68470116	10	-	24336569	HL60	viability	AGGAATGGATAACCGGTACCTGG	DNA2	ENSG00000138346	-1.8316136837857018	[512]	[304]	-9	hSpCas9	negative selection	2261005
68470100	68470123	10	-	24336569	HL60	viability	TGAGCACAGGAATGGATAACCGG	DNA2	ENSG00000138346	-1.4960757120696986	[1128]	[846]	-8	hSpCas9	negative selection	2261006
68470108	68470131	10	-	24336569	HL60	viability	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-0.09161571790452061	[926]	[1840]	-1	hSpCas9	negative selection	2261007
68470113	68470136	10	+	24336569	HL60	viability	CCTGTGCTCAGAACTGTTCTTGG	DNA2	ENSG00000138346	0.340492812589738	[311]	[835]	3	hSpCas9	negative selection	2261008
68470118	68470141	10	+	24336569	HL60	viability	GCTCAGAACTGTTCTTGGAAAGG	DNA2	ENSG00000138346	-0.9806919195749139	[621]	[666]	-7	hSpCas9	negative selection	2261009
68470147	68470170	10	-	24336569	HL60	viability	CTTTAGATTTCAGAAGAAAGTGG	DNA2	ENSG00000138346	1.131529622705302	[32]	[152]	8	hSpCas9	negative selection	2261010
68471779	68471802	10	+	24336569	HL60	viability	CTCTCCGCTCACAGCTCCGCCGG	DNA2	ENSG00000138346	-0.3905329842023992	[362]	[585]	-3	hSpCas9	negative selection	2261011
68471798	68471821	10	-	24336569	HL60	viability	TTGGGAGGAGGCGGAGCTGCCGG	DNA2	ENSG00000138346	0.1543488364698733	[1069]	[2519]	1	hSpCas9	negative selection	2261012
68471831	68471854	10	-	24336569	HL60	viability	GAACGAACTGGAGCTGCTGATGG	DNA2	ENSG00000138346	-0.5703668377573572	[373]	[532]	-5	hSpCas9	negative selection	2261013
68471843	68471866	10	-	24336569	HL60	viability	GATGGAGCAGCTGAACGAACTGG	DNA2	ENSG00000138346	0.022567120701590948	[768]	[1652]	0	hSpCas9	negative selection	2261014
68470093	68470116	10	-	24336569	KBM7	viability	AGGAATGGATAACCGGTACCTGG	DNA2	ENSG00000138346	-2.8570996908601605	[347]	[130]	-9	hSpCas9	negative selection	2328182
68470100	68470123	10	-	24336569	KBM7	viability	TGAGCACAGGAATGGATAACCGG	DNA2	ENSG00000138346	-3.784380567917775	[974]	[192]	-9	hSpCas9	negative selection	2328183
68470108	68470131	10	-	24336569	KBM7	viability	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-1.0925526378325772	[766]	[980]	-7	hSpCas9	negative selection	2328184
68470113	68470136	10	+	24336569	KBM7	viability	CCTGTGCTCAGAACTGTTCTTGG	DNA2	ENSG00000138346	0.32978791290153037	[249]	[856]	3	hSpCas9	negative selection	2328185
68470118	68470141	10	+	24336569	KBM7	viability	GCTCAGAACTGTTCTTGGAAAGG	DNA2	ENSG00000138346	-1.8993183770405244	[490]	[358]	-8	hSpCas9	negative selection	2328186
68470147	68470170	10	-	24336569	KBM7	viability	CTTTAGATTTCAGAAGAAAGTGG	DNA2	ENSG00000138346	-3.535042037799222	[152]	[35]	-9	hSpCas9	negative selection	2328187
68471779	68471802	10	+	24336569	KBM7	viability	CTCTCCGCTCACAGCTCCGCCGG	DNA2	ENSG00000138346	-0.6300285073853898	[281]	[496]	-5	hSpCas9	negative selection	2328188
68471798	68471821	10	-	24336569	KBM7	viability	TTGGGAGGAGGCGGAGCTGCCGG	DNA2	ENSG00000138346	-0.745883686910346	[794]	[1292]	-5	hSpCas9	negative selection	2328189
68471831	68471854	10	-	24336569	KBM7	viability	GAACGAACTGGAGCTGCTGATGG	DNA2	ENSG00000138346	-0.2863666264431436	[202]	[453]	-2	hSpCas9	negative selection	2328190
68471843	68471866	10	-	24336569	KBM7	viability	GATGGAGCAGCTGAACGAACTGG	DNA2	ENSG00000138346	-0.050243699003497455	[655]	[1727]	0	hSpCas9	negative selection	2328191
68472073	68472096	10	-	25494202	A375	resistance to PLX-4720 (puromycin)	AAGCAAGGGAGCAAAGGCAGGGG	DNA2	ENSG00000138346	0.4911264505249191	[84,51]	[20,19]	2	dCas9-VP64	positive selection	2393566
68472047	68472070	10	-	25494202	A375	resistance to PLX-4720 (puromycin)	GAGCCCTGCTGCTCAGGTGAGGG	DNA2	ENSG00000138346	0.8093954406992403	[16,7]	[1,6]	3	dCas9-VP64	positive selection	2393567
68460000	68460023	10	-	25494202	A375	resistance to PLX-4720 (puromycin)	TGGAGTCTTGCTCTCTTGCCCAG	DNA2	ENSG00000138346	-1.8753616173827001	[293,134]	[14,9]	-9	dCas9-VP64	positive selection	2400770
68454711	68454734	10	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGAAGAATCGCTTGAACCTGGG	DNA2	ENSG00000138346	0.25493722011269604	[40,19]	[10,3]	1	dCas9-VP64	positive selection	2412323
68427980	68428003	10	-	25494202	A375	resistance to PLX-4720 (puromycin)	GGAGTGCAGTGGTGCGATCTGAG	DNA2	ENSG00000138346	4.070372888524917	[22,16]	[45,107]	9	dCas9-VP64	positive selection	2443417
68444629	68444652	10	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGAGAATCGCTTGAACCCAAG	DNA2	ENSG00000138346	-1.1949452889942442	[147,110]	[6,17]	-7	dCas9-VP64	positive selection	2450025
68444312	68444335	10	-	25494202	A375	resistance to PLX-4720 (puromycin)	CACTGCAACCTCCGCCTCCCTAG	DNA2	ENSG00000138346	0.6259309833286419	[228,309]	[35,151]	2	dCas9-VP64	positive selection	2450432
68429924	68429947	10	-	25494202	A375	resistance to PLX-4720 (puromycin)	CGCGCCACTGCACTCCAGCCTAG	DNA2	ENSG00000138346	-0.533989545843368	[184,280]	[23,46]	-3	dCas9-VP64	positive selection	2477362
68472073	68472096	10	-	25494202	A375	resistance to PLX-4720 (zeocin)	AAGCAAGGGAGCAAAGGCAGGGG	DNA2	ENSG00000138346	-0.33270961967014023	[202,208]	[57,48]	-3	dCas9-VP64	positive selection	2488821
68472047	68472070	10	-	25494202	A375	resistance to PLX-4720 (zeocin)	GAGCCCTGCTGCTCAGGTGAGGG	DNA2	ENSG00000138346	0.889835579247435	[54,59]	[25,41]	6	dCas9-VP64	positive selection	2488822
68460000	68460023	10	-	25494202	A375	resistance to PLX-4720 (zeocin)	TGGAGTCTTGCTCTCTTGCCCAG	DNA2	ENSG00000138346	0.1708097924139956	[97,83]	[32,33]	1	dCas9-VP64	positive selection	2496025
68454711	68454734	10	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGAAGAATCGCTTGAACCTGGG	DNA2	ENSG00000138346	-0.6152755658460514	[139,54]	[28,12]	-6	dCas9-VP64	positive selection	2507578
68427980	68428003	10	-	25494202	A375	resistance to PLX-4720 (zeocin)	GGAGTGCAGTGGTGCGATCTGAG	DNA2	ENSG00000138346	1.6841538162097147	[121,126]	[189,75]	8	dCas9-VP64	positive selection	2538672
68444629	68444652	10	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGAGAATCGCTTGAACCCAAG	DNA2	ENSG00000138346	1.2597172262171965	[381,372]	[459,141]	7	dCas9-VP64	positive selection	2545280
68444312	68444335	10	-	25494202	A375	resistance to PLX-4720 (zeocin)	CACTGCAACCTCCGCCTCCCTAG	DNA2	ENSG00000138346	0.8832307312434098	[227,267]	[69,222]	6	dCas9-VP64	positive selection	2545687
68429924	68429947	10	-	25494202	A375	resistance to PLX-4720 (zeocin)	CGCGCCACTGCACTCCAGCCTAG	DNA2	ENSG00000138346	0.47261086320192236	[687,417]	[369,140]	4	dCas9-VP64	positive selection	2572617
68471886	68471909	10	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ACTGTAGACAGAAAAGACAGCGG	DNA2	ENSG00000138346	0.22296889776976447	[3,2]	[4,2]	5	hSpCas9	positive selection	2983855
68471856	68471879	10	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCTGCTCCATCCTGGACGCGGGG	DNA2	ENSG00000138346	0.7044562875199004	[2,2]	[4,3]	9	hSpCas9	positive selection	2983856
68468262	68468285	10	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGAGATATCATTCATTTGGAGGG	DNA2	ENSG00000138346	-0.36441433559983466	[3,3]	[2,1]	-5	hSpCas9	positive selection	2983857
68472087	68472110	10	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTATTCCCAGTCCTAAGCAAGGG	DNA2	ENSG00000138346	0.40677824452501765	[3,3]	[4,4]	8	hSpCas9	positive selection	2983858
68471886	68471909	10	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ACTGTAGACAGAAAAGACAGCGG	DNA2	ENSG00000138346	-0.21485103923013157	[3,3]	[3,0]	-3	hSpCas9	positive selection	3051713
68471856	68471879	10	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCTGCTCCATCCTGGACGCGGGG	DNA2	ENSG00000138346	-0.3224417830790508	[2,2]	[1,1]	-5	hSpCas9	positive selection	3051714
68468262	68468285	10	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGAGATATCATTCATTTGGAGGG	DNA2	ENSG00000138346	-0.005342377911513321	[3,3]	[1,2]	0	hSpCas9	positive selection	3051715
68472087	68472110	10	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTATTCCCAGTCCTAAGCAAGGG	DNA2	ENSG00000138346	0.021323887030779545	[3,3]	[3,1]	0	hSpCas9	positive selection	3051716
68471885	68471908	10	+	26780180	HT29	viability (Avana library 4 designs)	ACTGTAGACAGAAAAGACAGCGG	DNA2	ENSG00000138346	2.51122659970536	[]	[]	8	hSpCas9	negative selection	3420626
68471855	68471878	10	+	26780180	HT29	viability (Avana library 4 designs)	GCTGCTCCATCCTGGACGCGGGG	DNA2	ENSG00000138346	1.07951660071837	[]	[]	4	hSpCas9	negative selection	3420627
68468262	68468285	10	-	26780180	HT29	viability (Avana library 4 designs)	GGAGATATCATTCATTTGGAGGG	DNA2	ENSG00000138346	5.03480372165437	[]	[]	9	hSpCas9	negative selection	3420628
68472087	68472110	10	-	26780180	HT29	viability (Avana library 4 designs)	GTATTCCCAGTCCTAAGCAAGGG	DNA2	ENSG00000138346	1.77316372034495	[]	[]	6	hSpCas9	negative selection	3420629
68472087	68472110	10	-	26780180	A375	viability (Avana lentiCRISPRv2)	GTATTCCCAGTCCTAAGCAAGGG	DNA2	ENSG00000138346	-1.50431984991859	[]	[]	-2	hSpCas9	negative selection	3500397
68471885	68471908	10	+	26780180	A375	viability (Avana lentiCRISPRv2)	ACTGTAGACAGAAAAGACAGCGG	DNA2	ENSG00000138346	-6.96140267325877	[]	[]	-6	hSpCas9	negative selection	3500398
68468262	68468285	10	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGAGATATCATTCATTTGGAGGG	DNA2	ENSG00000138346	-19.9166879447124	[]	[]	-9	hSpCas9	negative selection	3500399
68471855	68471878	10	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCTGCTCCATCCTGGACGCGGGG	DNA2	ENSG00000138346	4.37564518689547	[]	[]	7	hSpCas9	negative selection	3500400
68465778	68465801	10	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCCACACGCCAAATGCTAATTGG	DNA2	ENSG00000138346	-7.98724672716691	[]	[]	-7	hSpCas9	negative selection	3500401
68459158	68459181	10	+	26780180	A375	viability (Avana lentiCRISPRv2)	CCTGCCCATTTACAAAACGAAGG	DNA2	ENSG00000138346	-10.8375644947223	[]	[]	-8	hSpCas9	negative selection	3500402
68472087	68472110	10	-	26780180	A375	viability (Avana lentiGuide)	GTATTCCCAGTCCTAAGCAAGGG	DNA2	ENSG00000138346	2.80590403340461	[]	[]	3	hSpCas9	negative selection	3609056
68471885	68471908	10	+	26780180	A375	viability (Avana lentiGuide)	ACTGTAGACAGAAAAGACAGCGG	DNA2	ENSG00000138346	22.779172956846	[]	[]	9	hSpCas9	negative selection	3609057
68468262	68468285	10	-	26780180	A375	viability (Avana lentiGuide)	GGAGATATCATTCATTTGGAGGG	DNA2	ENSG00000138346	21.7675855133403	[]	[]	9	hSpCas9	negative selection	3609058
68471855	68471878	10	+	26780180	A375	viability (Avana lentiGuide)	GCTGCTCCATCCTGGACGCGGGG	DNA2	ENSG00000138346	15.6681853338073	[]	[]	8	hSpCas9	negative selection	3609059
68465778	68465801	10	-	26780180	A375	viability (Avana lentiGuide)	GCCACACGCCAAATGCTAATTGG	DNA2	ENSG00000138346	-7.48702057832491	[]	[]	-9	hSpCas9	negative selection	3609060
68459158	68459181	10	+	26780180	A375	viability (Avana lentiGuide)	CCTGCCCATTTACAAAACGAAGG	DNA2	ENSG00000138346	21.3993633989518	[]	[]	9	hSpCas9	negative selection	3609061
68472087	68472110	10	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTATTCCCAGTCCTAAGCAAGGG	DNA2	ENSG00000138346	-0.0752384236168764	[5]	[5,4]	-1	hSpCas9	positive selection	3717715
68471885	68471908	10	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ACTGTAGACAGAAAAGACAGCGG	DNA2	ENSG00000138346	-1.1662975765888606	[5]	[1,1]	-9	hSpCas9	positive selection	3717716
68468262	68468285	10	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGAGATATCATTCATTTGGAGGG	DNA2	ENSG00000138346	-0.8557610181692394	[7]	[3,3]	-8	hSpCas9	positive selection	3717717
68471855	68471878	10	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTGCTCCATCCTGGACGCGGGG	DNA2	ENSG00000138346	0.16664113385444845	[4]	[5,4]	4	hSpCas9	positive selection	3717718
68465778	68465801	10	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCCACACGCCAAATGCTAATTGG	DNA2	ENSG00000138346	-0.30293821712335256	[4]	[4,1]	-4	hSpCas9	positive selection	3717719
68459158	68459181	10	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCTGCCCATTTACAAAACGAAGG	DNA2	ENSG00000138346	-1.2404965915731092	[4]	[1,1]	-9	hSpCas9	positive selection	3717720
68472087	68472110	10	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTATTCCCAGTCCTAAGCAAGGG	DNA2	ENSG00000138346	-0.187311357950306	[5]	[3,3]	-3	hSpCas9	positive selection	3826322
68471885	68471908	10	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ACTGTAGACAGAAAAGACAGCGG	DNA2	ENSG00000138346	-1.9818547587876068	[5]	[0,0]	-9	hSpCas9	positive selection	3826323
68468262	68468285	10	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGAGATATCATTCATTTGGAGGG	DNA2	ENSG00000138346	-0.9245234095418869	[5]	[1,2]	-8	hSpCas9	positive selection	3826324
68471855	68471878	10	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTGCTCCATCCTGGACGCGGGG	DNA2	ENSG00000138346	-0.4036248537987925	[5]	[3,2]	-5	hSpCas9	positive selection	3826325
68465778	68465801	10	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCCACACGCCAAATGCTAATTGG	DNA2	ENSG00000138346	0.013715771368044482	[5]	[4,4]	0	hSpCas9	positive selection	3826326
68459158	68459181	10	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCTGCCCATTTACAAAACGAAGG	DNA2	ENSG00000138346	-1.792975835744733	[5]	[0,0]	-9	hSpCas9	positive selection	3826327
68430936	68430959	10	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.6670158028174558	[1]	[1,0]	-9	hSpCas9	positive selection	4311217
68471519	68471542	10	+	27661255	K562	viability	GGCCGAAACTCCTCAACTTAGGG	DNA2	ENSG00000138346	-0.2610757265691207	[515,385]	[292,309]	-6	dCas9-KRAB	negative selection	5475334
68471629	68471652	10	+	27661255	K562	viability	GAGGCAGGCCCCGACTCCGGAGG	DNA2	ENSG00000138346	-1.1759693860441336	[877,1079]	[380,313]	-8	dCas9-KRAB	negative selection	5475335
68471663	68471686	10	-	27661255	K562	viability	GGGACCCGGTGCAGCTCCCTGGG	DNA2	ENSG00000138346	-0.6706453255042405	[807,912]	[533,342]	-8	dCas9-KRAB	negative selection	5475336
68430936	68430959	10	-	27260156	BXPC3	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.8305001247737369	[181]	[136,79,121,83]	-9	hSpCas9	negative selection	5583677
68430936	68430959	10	-	27260156	A673	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.7381680556223142	[181]	[173,135,87,130]	-9	hSpCas9	negative selection	5704928
68430936	68430959	10	-	27260156	A375	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-2.9820541200219712	[181]	[35,19,17,31]	-9	hSpCas9	negative selection	5826179
68430936	68430959	10	-	27260156	COLO741	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.8068850956376177	[181]	[164,184,56]	-9	hSpCas9	negative selection	5947430
68430936	68430959	10	-	27260156	CAL120	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.9086796934032084	[181]	[72,121,158]	-8	hSpCas9	negative selection	6068681
68430936	68430959	10	-	27260156	CADOES1	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-1.1568823634394318	[181]	[109,68,62,60]	-9	hSpCas9	negative selection	6189932
68430936	68430959	10	-	27260156	EWS502	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-1.6895814790526007	[181]	[36,77,80,43]	-9	hSpCas9	negative selection	6311183
68430936	68430959	10	-	27260156	EW8	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.901842187598878	[181]	[171,53,53,49]	-9	hSpCas9	negative selection	6432434
68430936	68430959	10	-	27260156	CORL105	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.6304234323404403	[181]	[145,139,88,167]	-8	hSpCas9	negative selection	6553685
68430936	68430959	10	-	27260156	HS294T	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.9012801526703367	[181]	[71,16,25,31]	-8	hSpCas9	negative selection	6674936
68430936	68430959	10	-	27260156	HCC44	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-1.8598281843823679	[181]	[48,32,91,60]	-9	hSpCas9	negative selection	6796187
68430936	68430959	10	-	27260156	G402	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-2.0308434698521163	[181]	[68,1,0,139]	-9	hSpCas9	negative selection	6917438
68430936	68430959	10	-	27260156	L33	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.9992020382572124	[181]	[115,24,68,76]	-9	hSpCas9	negative selection	7038689
68430936	68430959	10	-	27260156	K562	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-1.4881377406434253	[181]	[14,151,1,61]	-9	hSpCas9	negative selection	7159940
68430936	68430959	10	-	27260156	HT29	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-1.01822790941655	[181]	[91,167,71,107]	-8	hSpCas9	negative selection	7281191
68430936	68430959	10	-	27260156	MHHES1	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.7968926722305061	[181]	[135,225,99,38]	-9	hSpCas9	negative selection	7402442
68430936	68430959	10	-	27260156	MEWO	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.5830487508172757	[181]	[159,102,86]	-8	hSpCas9	negative selection	7523693
68430936	68430959	10	-	27260156	LNCAPCLONEFGC	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-1.0772407298468631	[181]	[54,76,104,79]	-9	hSpCas9	negative selection	7644944
68430936	68430959	10	-	27260156	PANC0327	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.38577353143182536	[181]	[28,340,35,52]	-5	hSpCas9	negative selection	7766195
68430936	68430959	10	-	27260156	NCIH2009	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-2.169309428476334	[181]	[110,15,53]	-9	hSpCas9	negative selection	7887446
68430936	68430959	10	-	27260156	NCIH1373	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-2.2367426889594224	[181]	[18,33,21,25]	-9	hSpCas9	negative selection	8008697
68430936	68430959	10	-	27260156	PATU8902	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-1.642800294692015	[181]	[195,36,7,102]	-8	hSpCas9	negative selection	8129948
68430936	68430959	10	-	27260156	PANC1	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-2.8762259669666004	[181]	[37,15,12,16]	-9	hSpCas9	negative selection	8251199
68430936	68430959	10	-	27260156	PANC0813	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-1.2875416045124726	[181]	[37,67,153,85]	-9	hSpCas9	negative selection	8372450
68430936	68430959	10	-	27260156	RDES	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-1.2213344263290216	[181]	[112,46,71,127]	-9	hSpCas9	negative selection	8493701
68430936	68430959	10	-	27260156	PC3	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.9116767325737887	[181]	[40,114,229,66]	-9	hSpCas9	negative selection	8614952
68430936	68430959	10	-	27260156	PATU8988T	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-1.3671930426084464	[181]	[82,36,47,104]	-9	hSpCas9	negative selection	8736203
68430936	68430959	10	-	27260156	T47D	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-1.2676976020018285	[181]	[99,54,106,92]	-9	hSpCas9	negative selection	8857454
68430936	68430959	10	-	27260156	SU8686	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-1.605017811775093	[181]	[35,48,96,59]	-9	hSpCas9	negative selection	8978705
68430936	68430959	10	-	27260156	SKES1	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-1.0510040676463426	[181]	[53,89,62,132]	-9	hSpCas9	negative selection	9099956
68430936	68430959	10	-	27260156	TOV112D	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.16518523411981634	[181]	[179,223,151,111]	-3	hSpCas9	negative selection	9221207
68430936	68430959	10	-	27260156	TC71	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.9986130096738588	[181]	[99,57,106,126]	-9	hSpCas9	negative selection	9342458
68430936	68430959	10	-	27260156	TC32	viability	TCTCACTTTGTTGCCCAGGCAAG	DNA2	ENSG00000138346	-0.880526013781683	[181]	[56,54,156,129]	-9	hSpCas9	negative selection	9463709
68422699	68422722	10	+	27869803	HPAFII	viability after 27 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-2.8557407754822424	[367]	[5,43,NaN]	-9	hSpCas9	negative selection	9538353
68431887	68431910	10	-	27869803	HPAFII	viability after 27 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-0.5462174534317963	[327]	[50,173,NaN]	-4	hSpCas9	negative selection	9538354
68442908	68442931	10	+	27869803	HPAFII	viability after 27 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-2.9252822073510627	[242]	[6,24,NaN]	-9	hSpCas9	negative selection	9538355
68446304	68446327	10	+	27869803	HPAFII	viability after 27 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-5.03848530429779	[232]	[6,0,NaN]	-9	hSpCas9	negative selection	9538356
68470108	68470131	10	-	27869803	HPAFII	viability after 27 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-1.2308320591372122	[277]	[22,94,NaN]	-7	hSpCas9	negative selection	9538357
68471853	68471876	10	+	27869803	HPAFII	viability after 27 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.5478578719798952	[860]	[445,195,NaN]	-4	hSpCas9	negative selection	9538358
68422699	68422722	10	+	27869803	HPAFII	viability after 15 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-1.9260675126816174	[367]	[182,54,NaN]	-9	hSpCas9	negative selection	9620802
68431887	68431910	10	-	27869803	HPAFII	viability after 15 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-0.4594567668552708	[327]	[264,250,NaN]	-5	hSpCas9	negative selection	9620803
68442908	68442931	10	+	27869803	HPAFII	viability after 15 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-1.5063334881168038	[242]	[49,117,NaN]	-8	hSpCas9	negative selection	9620804
68446304	68446327	10	+	27869803	HPAFII	viability after 15 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-2.833861106789032	[232]	[89,0,NaN]	-9	hSpCas9	negative selection	9620805
68470108	68470131	10	-	27869803	HPAFII	viability after 15 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-0.2792925954769085	[277]	[305,208,NaN]	-3	hSpCas9	negative selection	9620806
68471853	68471876	10	+	27869803	HPAFII	viability after 15 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.34535248461195334	[860]	[1093,500,NaN]	-4	hSpCas9	negative selection	9620807
68422699	68422722	10	+	27869803	ASPC1	viability after 36 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-1.5117017969149074	[877]	[197,100,47]	-8	hSpCas9	negative selection	9703251
68431887	68431910	10	-	27869803	ASPC1	viability after 36 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	0.5399245378725609	[1197]	[1001,247,610]	5	hSpCas9	negative selection	9703252
68442908	68442931	10	+	27869803	ASPC1	viability after 36 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-0.2951899426710616	[752]	[252,388,45]	-3	hSpCas9	negative selection	9703253
68446304	68446327	10	+	27869803	ASPC1	viability after 36 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-0.37592864260364245	[594]	[214,213,76]	-4	hSpCas9	negative selection	9703254
68470108	68470131	10	-	27869803	ASPC1	viability after 36 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	0.0577939124358893	[710]	[133,499,150]	0	hSpCas9	negative selection	9703255
68471853	68471876	10	+	27869803	ASPC1	viability after 36 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.13824968021833084	[1917]	[674,435,691]	-1	hSpCas9	negative selection	9703256
68422699	68422722	10	+	27869803	PATU8988S	viability after 35 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-3.0896801368021367	[739]	[38,30,NaN]	-9	hSpCas9	negative selection	9785700
68431887	68431910	10	-	27869803	PATU8988S	viability after 35 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-0.8711837206768	[673]	[105,190,NaN]	-7	hSpCas9	negative selection	9785701
68442908	68442931	10	+	27869803	PATU8988S	viability after 35 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	0.18078147575283404	[559]	[320,189,NaN]	2	hSpCas9	negative selection	9785702
68446304	68446327	10	+	27869803	PATU8988S	viability after 35 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-5.802658959555608	[554]	[5,1,NaN]	-9	hSpCas9	negative selection	9785703
68470108	68470131	10	-	27869803	PATU8988S	viability after 35 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-0.46724174102837945	[550]	[169,150,NaN]	-5	hSpCas9	negative selection	9785704
68471853	68471876	10	+	27869803	PATU8988S	viability after 35 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.07889884931957059	[1875]	[867,561,NaN]	-1	hSpCas9	negative selection	9785705
68422699	68422722	10	+	27869803	PATU8988S	viability after 31 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-1.9365141653484328	[739]	[106,38,NaN]	-9	hSpCas9	negative selection	9868149
68431887	68431910	10	-	27869803	PATU8988S	viability after 31 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-0.5829264611989465	[673]	[90,291,NaN]	-6	hSpCas9	negative selection	9868150
68442908	68442931	10	+	27869803	PATU8988S	viability after 31 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	0.06757685464933982	[559]	[255,205,NaN]	0	hSpCas9	negative selection	9868151
68446304	68446327	10	+	27869803	PATU8988S	viability after 31 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-5.63934656574129	[554]	[3,4,NaN]	-9	hSpCas9	negative selection	9868152
68470108	68470131	10	-	27869803	PATU8988S	viability after 31 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-0.1730507933507984	[550]	[160,237,NaN]	-2	hSpCas9	negative selection	9868153
68471853	68471876	10	+	27869803	PATU8988S	viability after 31 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.13817303510600176	[1875]	[695,658,NaN]	-1	hSpCas9	negative selection	9868154
68422699	68422722	10	+	27869803	HPAFII	viability after 35 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-4.520949065646046	[367]	[1,14,NaN]	-9	hSpCas9	negative selection	9950598
68431887	68431910	10	-	27869803	HPAFII	viability after 35 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-1.6869159596038343	[327]	[20,85,NaN]	-7	hSpCas9	negative selection	9950599
68442908	68442931	10	+	27869803	HPAFII	viability after 35 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-2.896430298335171	[242]	[0,33,NaN]	-8	hSpCas9	negative selection	9950600
68446304	68446327	10	+	27869803	HPAFII	viability after 35 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-4.227560614826605	[232]	[10,0,NaN]	-9	hSpCas9	negative selection	9950601
68470108	68470131	10	-	27869803	HPAFII	viability after 35 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-2.7009393631632426	[277]	[15,27,NaN]	-8	hSpCas9	negative selection	9950602
68471853	68471876	10	+	27869803	HPAFII	viability after 35 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.4494747518116582	[860]	[480,136,NaN]	-3	hSpCas9	negative selection	9950603
68422699	68422722	10	+	27869803	HPAFII	viability after 31 days	TGCTTCACGGTTTAGCACCAGGG	DNA2	ENSG00000138346	-4.1523622312516935	[367]	[2,20,NaN]	-9	hSpCas9	negative selection	10033047
68431887	68431910	10	-	27869803	HPAFII	viability after 31 days	ATCGTGGGTATGCCTGGGACAGG	DNA2	ENSG00000138346	-1.323807612368176	[327]	[51,96,NaN]	-7	hSpCas9	negative selection	10033048
68442908	68442931	10	+	27869803	HPAFII	viability after 31 days	ACCACTTACATTTCCGAAGCAGG	DNA2	ENSG00000138346	-1.4887689471035555	[242]	[5,94,NaN]	-7	hSpCas9	negative selection	10033049
68446304	68446327	10	+	27869803	HPAFII	viability after 31 days	TCTAGATGGTTGGCAGGCACAGG	DNA2	ENSG00000138346	-7.0308149449790225	[232]	[0,0,NaN]	-9	hSpCas9	negative selection	10033050
68470108	68470131	10	-	27869803	HPAFII	viability after 31 days	AACAGTTCTGAGCACAGGAATGG	DNA2	ENSG00000138346	-1.4272335780688905	[277]	[35,81,NaN]	-7	hSpCas9	negative selection	10033051
68471853	68471876	10	+	27869803	HPAFII	viability after 31 days	CAGCTGCTCCATCCTGGACGCGG	DNA2	ENSG00000138346	-0.7258622046787175	[860]	[373,202,NaN]	-5	hSpCas9	negative selection	10033052