| 49493148 | 49493171 | 10 | + | 26472758 | Jiyoye | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 1.369373348793489 | [57] | [112] | 7 | hSpCas9 | negative selection | 51422 | 49482733 | 49482756 | 10 | + | 26472758 | Jiyoye | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | -2.513390150999722 | [105] | [13] | -9 | hSpCas9 | negative selection | 51423 | 49482798 | 49482821 | 10 | - | 26472758 | Jiyoye | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | 0.20618832377269636 | [222] | [193] | 1 | hSpCas9 | negative selection | 51424 | 49482791 | 49482814 | 10 | + | 26472758 | Jiyoye | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | 0.40717538150587274 | [0] | [0] | 3 | hSpCas9 | negative selection | 51425 | 49493148 | 49493171 | 10 | + | 26472758 | KBM7 | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.8374439859350895 | [141,142] | [75,159] | 8 | hSpCas9 | negative selection | 242540 | 49482733 | 49482756 | 10 | + | 26472758 | KBM7 | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | -0.34240979560904516 | [252,330] | [66,148] | -3 | hSpCas9 | negative selection | 242541 | 49482798 | 49482821 | 10 | - | 26472758 | KBM7 | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | -0.4066398298347268 | [906,583] | [356,172] | -4 | hSpCas9 | negative selection | 242542 | 49482791 | 49482814 | 10 | + | 26472758 | KBM7 | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | -1.1421765130608321 | [37,13] | [8,1] | -7 | hSpCas9 | negative selection | 242543 | 49493148 | 49493171 | 10 | + | 26472758 | Raji | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.850388229237103 | [100] | [12] | -6 | hSpCas9 | negative selection | 433658 | 49482733 | 49482756 | 10 | + | 26472758 | Raji | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | 0.3000286133159954 | [118] | [33] | 3 | hSpCas9 | negative selection | 433659 | 49482798 | 49482821 | 10 | - | 26472758 | Raji | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | -0.4843363315228652 | [427] | [70] | -4 | hSpCas9 | negative selection | 433660 | 49482791 | 49482814 | 10 | + | 26472758 | Raji | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | 3.6923460360947553 | [0] | [2] | 9 | hSpCas9 | negative selection | 433661 | 49493148 | 49493171 | 10 | + | 26472758 | K562 | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -1.371437781000493 | [235] | [76] | -6 | hSpCas9 | negative selection | 624776 | 49482733 | 49482756 | 10 | + | 26472758 | K562 | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | -1.2974750511628232 | [197] | [67] | -6 | hSpCas9 | negative selection | 624777 | 49482798 | 49482821 | 10 | - | 26472758 | K562 | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | -0.6502596784773325 | [646] | [347] | -4 | hSpCas9 | negative selection | 624778 | 49482791 | 49482814 | 10 | + | 26472758 | K562 | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | 0.24441872766644757 | [0] | [0] | 2 | hSpCas9 | negative selection | 624779 | 49472993 | 49473016 | 10 | - | 26627737 | DLD1 | viability | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 0.23166644804570324 | [461] | [155,204,151] | 2 | hSpCas9 | negative selection | 775057 | 49483395 | 49483418 | 10 | - | 26627737 | DLD1 | viability | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | -0.5516172797063355 | [2236] | [490,557,397] | -5 | hSpCas9 | negative selection | 775058 | 49493148 | 49493171 | 10 | + | 26627737 | DLD1 | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.5631375457464672 | [1216] | [303,276,200] | -5 | hSpCas9 | negative selection | 775059 | 49500643 | 49500666 | 10 | - | 26627737 | DLD1 | viability | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | -0.8244492263773167 | [170] | [31,42,17] | -7 | hSpCas9 | negative selection | 775060 | 49472993 | 49473016 | 10 | - | 26627737 | GBM cells | viability after 5 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 0.31395137416452945 | [275] | [152,214] | 5 | hSpCas9 | negative selection | 857372 | 49483395 | 49483418 | 10 | - | 26627737 | GBM cells | viability after 5 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.15812656976707085 | [944] | [585,544] | 2 | hSpCas9 | negative selection | 857373 | 49493148 | 49493171 | 10 | + | 26627737 | GBM cells | viability after 5 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.0001209790254559362 | [537] | [250,325] | 0 | hSpCas9 | negative selection | 857374 | 49500643 | 49500666 | 10 | - | 26627737 | GBM cells | viability after 5 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | -0.3147928185845398 | [137] | [43,74] | -5 | hSpCas9 | negative selection | 857375 | 49472993 | 49473016 | 10 | - | 26627737 | GBM cells | viability after 13 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 0.4283199823227018 | [275] | [195,205] | 5 | hSpCas9 | negative selection | 939687 | 49483395 | 49483418 | 10 | - | 26627737 | GBM cells | viability after 13 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.21251958049905695 | [944] | [683,520] | 2 | hSpCas9 | negative selection | 939688 | 49493148 | 49493171 | 10 | + | 26627737 | GBM cells | viability after 13 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.22255669857787508 | [537] | [435,262] | 3 | hSpCas9 | negative selection | 939689 | 49500643 | 49500666 | 10 | - | 26627737 | GBM cells | viability after 13 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | -0.04285892383349066 | [137] | [59,82] | 0 | hSpCas9 | negative selection | 939690 | 49472993 | 49473016 | 10 | - | 26627737 | GBM cells | viability after 21 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 0.6489077535092029 | [275] | [255,215] | 6 | hSpCas9 | negative selection | 1022002 | 49483395 | 49483418 | 10 | - | 26627737 | GBM cells | viability after 21 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.09996251156823655 | [944] | [579,522] | 1 | hSpCas9 | negative selection | 1022003 | 49493148 | 49493171 | 10 | + | 26627737 | GBM cells | viability after 21 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.009097417041898037 | [537] | [290,296] | 0 | hSpCas9 | negative selection | 1022004 | 49500643 | 49500666 | 10 | - | 26627737 | GBM cells | viability after 21 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | -0.5583825101875101 | [137] | [52,48] | -5 | hSpCas9 | negative selection | 1022005 | 49472993 | 49473016 | 10 | - | 26627737 | RPE1 | viability after 9 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 0.9439587885659559 | [932] | [495,646] | 6 | hSpCas9 | negative selection | 1104317 | 49483395 | 49483418 | 10 | - | 26627737 | RPE1 | viability after 9 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.14561192233898934 | [1914] | [512,856] | 1 | hSpCas9 | negative selection | 1104318 | 49493148 | 49493171 | 10 | + | 26627737 | RPE1 | viability after 9 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.5981668321113025 | [1377] | [339,213] | -4 | hSpCas9 | negative selection | 1104319 | 49500643 | 49500666 | 10 | - | 26627737 | RPE1 | viability after 9 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | 0.3235484788479968 | [483] | [93,312] | 2 | hSpCas9 | negative selection | 1104320 | 49472993 | 49473016 | 10 | - | 26627737 | RPE1 | viability after 12 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 1.031343907927101 | [932] | [506,517] | 6 | hSpCas9 | negative selection | 1186632 | 49483395 | 49483418 | 10 | - | 26627737 | RPE1 | viability after 12 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | -0.005810157239261038 | [1914] | [356,676] | 0 | hSpCas9 | negative selection | 1186633 | 49493148 | 49493171 | 10 | + | 26627737 | RPE1 | viability after 12 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.6176500702873717 | [1377] | [301,176] | -4 | hSpCas9 | negative selection | 1186634 | 49500643 | 49500666 | 10 | - | 26627737 | RPE1 | viability after 12 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | 0.7655237159639473 | [483] | [154,290] | 5 | hSpCas9 | negative selection | 1186635 | 49472993 | 49473016 | 10 | - | 26627737 | RPE1 | viability after 15 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 0.8937721993862413 | [932] | [468,510] | 5 | hSpCas9 | negative selection | 1268947 | 49483395 | 49483418 | 10 | - | 26627737 | RPE1 | viability after 15 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.30822963817152216 | [1914] | [600,737] | 2 | hSpCas9 | negative selection | 1268948 | 49493148 | 49493171 | 10 | + | 26627737 | RPE1 | viability after 15 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.6655570515794719 | [1377] | [315,177] | -4 | hSpCas9 | negative selection | 1268949 | 49500643 | 49500666 | 10 | - | 26627737 | RPE1 | viability after 15 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | 1.2531948705134381 | [483] | [474,182] | 7 | hSpCas9 | negative selection | 1268950 | 49472993 | 49473016 | 10 | - | 26627737 | RPE1 | viability after 18 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 0.7288875690068854 | [932] | [396,438] | 4 | hSpCas9 | negative selection | 1351262 | 49483395 | 49483418 | 10 | - | 26627737 | RPE1 | viability after 18 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | -0.08698875386806004 | [1914] | [327,655] | 0 | hSpCas9 | negative selection | 1351263 | 49493148 | 49493171 | 10 | + | 26627737 | RPE1 | viability after 18 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.8615150252072657 | [1377] | [267,136] | -5 | hSpCas9 | negative selection | 1351264 | 49500643 | 49500666 | 10 | - | 26627737 | RPE1 | viability after 18 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | 0.6115810891754192 | [483] | [157,243] | 4 | hSpCas9 | negative selection | 1351265 | 49472993 | 49473016 | 10 | - | 26627737 | HeLa | viability after 8 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | -0.7040827733541808 | [690] | [392,57,150] | -6 | hSpCas9 | negative selection | 1433577 | 49483395 | 49483418 | 10 | - | 26627737 | HeLa | viability after 8 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.8035553145755367 | [975] | [1182,559,588] | 6 | hSpCas9 | negative selection | 1433578 | 49493148 | 49493171 | 10 | + | 26627737 | HeLa | viability after 8 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.041386136864011824 | [663] | [287,365,195] | 0 | hSpCas9 | negative selection | 1433579 | 49500643 | 49500666 | 10 | - | 26627737 | HeLa | viability after 8 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | 0.6470896201115 | [191] | [52,111,204] | 5 | hSpCas9 | negative selection | 1433580 | 49472993 | 49473016 | 10 | - | 26627737 | HeLa | viability after 12 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | -0.05826113477850037 | [690] | [384,179,270] | 0 | hSpCas9 | negative selection | 1515892 | 49483395 | 49483418 | 10 | - | 26627737 | HeLa | viability after 12 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.41342618208004844 | [975] | [438,713,436] | 3 | hSpCas9 | negative selection | 1515893 | 49493148 | 49493171 | 10 | + | 26627737 | HeLa | viability after 12 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.03998430655155194 | [663] | [338,319,184] | 0 | hSpCas9 | negative selection | 1515894 | 49500643 | 49500666 | 10 | - | 26627737 | HeLa | viability after 12 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | 0.4232999861425766 | [191] | [101,59,161] | 3 | hSpCas9 | negative selection | 1515895 | 49472993 | 49473016 | 10 | - | 26627737 | HeLa | viability after 15 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | -0.11108056880056072 | [690] | [236,364,172] | -1 | hSpCas9 | negative selection | 1598207 | 49483395 | 49483418 | 10 | - | 26627737 | HeLa | viability after 15 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.4566129587336176 | [975] | [306,615,729] | 4 | hSpCas9 | negative selection | 1598208 | 49493148 | 49493171 | 10 | + | 26627737 | HeLa | viability after 15 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.11902191094121473 | [663] | [121,236,400] | -1 | hSpCas9 | negative selection | 1598209 | 49500643 | 49500666 | 10 | - | 26627737 | HeLa | viability after 15 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | 0.7628281424362822 | [191] | [189,27,182] | 6 | hSpCas9 | negative selection | 1598210 | 49472993 | 49473016 | 10 | - | 26627737 | HeLa | viability after 18 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | -0.08512562245547706 | [690] | [165,304,172] | 0 | hSpCas9 | negative selection | 1680522 | 49483395 | 49483418 | 10 | - | 26627737 | HeLa | viability after 18 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.48110824118020346 | [975] | [212,523,729] | 4 | hSpCas9 | negative selection | 1680523 | 49493148 | 49493171 | 10 | + | 26627737 | HeLa | viability after 18 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.1197720899426703 | [663] | [80,196,400] | -1 | hSpCas9 | negative selection | 1680524 | 49500643 | 49500666 | 10 | - | 26627737 | HeLa | viability after 18 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | 0.80779879879016 | [191] | [134,23,182] | 6 | hSpCas9 | negative selection | 1680525 | 49472993 | 49473016 | 10 | - | 26627737 | HCT116 | viability after 6 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | -2.188221044376798 | [642] | [7,29] | -8 | hSpCas9 | negative selection | 1762837 | 49483395 | 49483418 | 10 | - | 26627737 | HCT116 | viability after 6 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.7450278905048968 | [2023] | [696,442] | 4 | hSpCas9 | negative selection | 1762838 | 49493148 | 49493171 | 10 | + | 26627737 | HCT116 | viability after 6 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.09486771666384025 | [820] | [203,74] | 0 | hSpCas9 | negative selection | 1762839 | 49500643 | 49500666 | 10 | - | 26627737 | HCT116 | viability after 6 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | -2.283380789949875 | [579] | [39,6] | -8 | hSpCas9 | negative selection | 1762840 | 49472993 | 49473016 | 10 | - | 26627737 | HCT116 | viability after 8 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 0.20486744653447542 | [322] | [163,271,178] | 2 | hSpCas9 | negative selection | 1845152 | 49483395 | 49483418 | 10 | - | 26627737 | HCT116 | viability after 8 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | -0.5223269890163915 | [1187] | [458,502,405] | -6 | hSpCas9 | negative selection | 1845153 | 49493148 | 49493171 | 10 | + | 26627737 | HCT116 | viability after 8 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.19138632832317504 | [562] | [247,324,241] | -2 | hSpCas9 | negative selection | 1845154 | 49500643 | 49500666 | 10 | - | 26627737 | HCT116 | viability after 8 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | -0.8103491079254102 | [193] | [35,49,95] | -7 | hSpCas9 | negative selection | 1845155 | 49472993 | 49473016 | 10 | - | 26627737 | HCT116 | viability after 9 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | -1.431218788659886 | [642] | [104,30] | -7 | hSpCas9 | negative selection | 1927467 | 49483395 | 49483418 | 10 | - | 26627737 | HCT116 | viability after 9 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.5286598706183061 | [2023] | [1073,546] | 4 | hSpCas9 | negative selection | 1927468 | 49493148 | 49493171 | 10 | + | 26627737 | HCT116 | viability after 9 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.5482766059490651 | [820] | [481,192] | 4 | hSpCas9 | negative selection | 1927469 | 49500643 | 49500666 | 10 | - | 26627737 | HCT116 | viability after 9 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | -0.24756116304100423 | [579] | [87,163] | -2 | hSpCas9 | negative selection | 1927470 | 49472993 | 49473016 | 10 | - | 26627737 | HCT116 | viability after 12 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 0.7057416481880756 | [322] | [235,270,326] | 6 | hSpCas9 | negative selection | 2009782 | 49483395 | 49483418 | 10 | - | 26627737 | HCT116 | viability after 12 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.10983007185552052 | [1187] | [680,570,765] | 1 | hSpCas9 | negative selection | 2009783 | 49493148 | 49493171 | 10 | + | 26627737 | HCT116 | viability after 12 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.06028687920764142 | [562] | [269,354,304] | 0 | hSpCas9 | negative selection | 2009784 | 49500643 | 49500666 | 10 | - | 26627737 | HCT116 | viability after 12 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | -0.770144219329657 | [193] | [51,99,28] | -7 | hSpCas9 | negative selection | 2009785 | 49472993 | 49473016 | 10 | - | 26627737 | HCT116 | viability after 15 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 0.3938743719214373 | [322] | [173,246,300] | 4 | hSpCas9 | negative selection | 2092097 | 49483395 | 49483418 | 10 | - | 26627737 | HCT116 | viability after 15 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | -0.5392343842652505 | [1187] | [512,450,449] | -5 | hSpCas9 | negative selection | 2092098 | 49493148 | 49493171 | 10 | + | 26627737 | HCT116 | viability after 15 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.08865156865746782 | [562] | [291,338,279] | -1 | hSpCas9 | negative selection | 2092099 | 49500643 | 49500666 | 10 | - | 26627737 | HCT116 | viability after 15 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | -0.6035805358238815 | [193] | [52,132,31] | -6 | hSpCas9 | negative selection | 2092100 | 49472993 | 49473016 | 10 | - | 26627737 | HCT116 | viability after 18 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 0.2514623596087062 | [322] | [127,163,270] | 2 | hSpCas9 | negative selection | 2174412 | 49483395 | 49483418 | 10 | - | 26627737 | HCT116 | viability after 18 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | -0.3128442949716599 | [1187] | [417,455,515] | -3 | hSpCas9 | negative selection | 2174413 | 49493148 | 49493171 | 10 | + | 26627737 | HCT116 | viability after 18 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.13223603525188077 | [562] | [260,372,253] | 1 | hSpCas9 | negative selection | 2174414 | 49500643 | 49500666 | 10 | - | 26627737 | HCT116 | viability after 18 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | -1.9545743211387203 | [193] | [3,28,39] | -9 | hSpCas9 | negative selection | 2174415 | 49490445 | 49490468 | 10 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAGGAGAATCTCTTGAACCCTAG | ERCC6 | ENSG00000225830 | 0.7055876385115556 | [3,484] | [1,182] | 3 | dCas9-VP64 | positive selection | 2452085 | 49490445 | 49490468 | 10 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAGGAGAATCTCTTGAACCCTAG | ERCC6 | ENSG00000225830 | -0.4319067453035411 | [83,67] | [14,20] | -4 | dCas9-VP64 | positive selection | 2547340 | 49493149 | 49493172 | 10 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.1115776709481146 | [4,4] | [3,3] | -1 | hSpCas9 | positive selection | 2986246 | 49482835 | 49482858 | 10 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | AGACAGAATGATCCGATGAGGGG | ERCC6 | ENSG00000225830 | -0.07614165477687504 | [4,3] | [5,1] | -1 | hSpCas9 | positive selection | 2986247 | 49505923 | 49505946 | 10 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | AGTGATGCTGAATTTGACGAAGG | ERCC6 | ENSG00000225830 | -0.8773607038620184 | [3,3] | [2,0] | -8 | hSpCas9 | positive selection | 2986248 | 49483341 | 49483364 | 10 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | TCATACCTGTTTGCAAGCAAGGG | ERCC6 | ENSG00000225830 | -0.4667701536755871 | [3,3] | [2,1] | -6 | hSpCas9 | positive selection | 2986249 | 49493149 | 49493172 | 10 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.11777529979582363 | [4,4] | [4,2] | 2 | hSpCas9 | positive selection | 3054104 | 49482835 | 49482858 | 10 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | AGACAGAATGATCCGATGAGGGG | ERCC6 | ENSG00000225830 | 0.26051243573919525 | [4,4] | [3,3] | 4 | hSpCas9 | positive selection | 3054105 | 49505923 | 49505946 | 10 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | AGTGATGCTGAATTTGACGAAGG | ERCC6 | ENSG00000225830 | -0.28120327036660625 | [3,3] | [3,0] | -4 | hSpCas9 | positive selection | 3054106 | 49483341 | 49483364 | 10 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | TCATACCTGTTTGCAAGCAAGGG | ERCC6 | ENSG00000225830 | -0.348331067586217 | [3,3] | [1,1] | -5 | hSpCas9 | positive selection | 3054107 | 49493148 | 49493171 | 10 | + | 26780180 | HT29 | viability (Avana library 4 designs) | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.229304138896734 | [] | [] | 0 | hSpCas9 | negative selection | 3423069 | 49482834 | 49482857 | 10 | + | 26780180 | HT29 | viability (Avana library 4 designs) | AGACAGAATGATCCGATGAGGGG | ERCC6 | ENSG00000225830 | 1.57330323726762 | [] | [] | 6 | hSpCas9 | negative selection | 3423070 | 49505923 | 49505946 | 10 | - | 26780180 | HT29 | viability (Avana library 4 designs) | AGTGATGCTGAATTTGACGAAGG | ERCC6 | ENSG00000225830 | 0.47105145642531 | [] | [] | 1 | hSpCas9 | negative selection | 3423071 | 49483340 | 49483363 | 10 | + | 26780180 | HT29 | viability (Avana library 4 designs) | TCATACCTGTTTGCAAGCAAGGG | ERCC6 | ENSG00000225830 | 0.208952840479088 | [] | [] | 0 | hSpCas9 | negative selection | 3423072 | 49483340 | 49483363 | 10 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TCATACCTGTTTGCAAGCAAGGG | ERCC6 | ENSG00000225830 | -1.36486669728929 | [] | [] | -2 | hSpCas9 | negative selection | 3504042 | 49493148 | 49493171 | 10 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 4.63441012582141 | [] | [] | 7 | hSpCas9 | negative selection | 3504043 | 49505923 | 49505946 | 10 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | AGTGATGCTGAATTTGACGAAGG | ERCC6 | ENSG00000225830 | 3.67919074960421 | [] | [] | 6 | hSpCas9 | negative selection | 3504044 | 49482834 | 49482857 | 10 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | AGACAGAATGATCCGATGAGGGG | ERCC6 | ENSG00000225830 | 0.98573725846401 | [] | [] | 1 | hSpCas9 | negative selection | 3504045 | 49482733 | 49482756 | 10 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | -6.39803279197368 | [] | [] | -6 | hSpCas9 | negative selection | 3504046 | 49482755 | 49482778 | 10 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCAACGTGCCTAACTTTCCCGGG | ERCC6 | ENSG00000225830 | 3.73448079892285 | [] | [] | 6 | hSpCas9 | negative selection | 3504047 | 49483340 | 49483363 | 10 | + | 26780180 | A375 | viability (Avana lentiGuide) | TCATACCTGTTTGCAAGCAAGGG | ERCC6 | ENSG00000225830 | -3.27850163789468 | [] | [] | -6 | hSpCas9 | negative selection | 3612701 | 49493148 | 49493171 | 10 | + | 26780180 | A375 | viability (Avana lentiGuide) | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.410291683119237 | [] | [] | 0 | hSpCas9 | negative selection | 3612702 | 49505923 | 49505946 | 10 | - | 26780180 | A375 | viability (Avana lentiGuide) | AGTGATGCTGAATTTGACGAAGG | ERCC6 | ENSG00000225830 | 1.61770723222195 | [] | [] | 1 | hSpCas9 | negative selection | 3612703 | 49482834 | 49482857 | 10 | + | 26780180 | A375 | viability (Avana lentiGuide) | AGACAGAATGATCCGATGAGGGG | ERCC6 | ENSG00000225830 | 1.3005429880178 | [] | [] | 1 | hSpCas9 | negative selection | 3612704 | 49482733 | 49482756 | 10 | + | 26780180 | A375 | viability (Avana lentiGuide) | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | 1.58913254568086 | [] | [] | 1 | hSpCas9 | negative selection | 3612705 | 49482755 | 49482778 | 10 | + | 26780180 | A375 | viability (Avana lentiGuide) | GCAACGTGCCTAACTTTCCCGGG | ERCC6 | ENSG00000225830 | 2.51188784059991 | [] | [] | 2 | hSpCas9 | negative selection | 3612706 | 49483340 | 49483363 | 10 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TCATACCTGTTTGCAAGCAAGGG | ERCC6 | ENSG00000225830 | -0.15069580272652655 | [5] | [4,4] | -2 | hSpCas9 | positive selection | 3721360 | 49493148 | 49493171 | 10 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.12591137305681802 | [5] | [6,5] | 3 | hSpCas9 | positive selection | 3721361 | 49505923 | 49505946 | 10 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | AGTGATGCTGAATTTGACGAAGG | ERCC6 | ENSG00000225830 | 0.061736935853959125 | [5] | [5,5] | 1 | hSpCas9 | positive selection | 3721362 | 49482834 | 49482857 | 10 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | AGACAGAATGATCCGATGAGGGG | ERCC6 | ENSG00000225830 | 0.01907184170436299 | [6] | [6,6] | 0 | hSpCas9 | positive selection | 3721363 | 49482733 | 49482756 | 10 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | -0.5489643767715878 | [4] | [3,2] | -7 | hSpCas9 | positive selection | 3721364 | 49482755 | 49482778 | 10 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCAACGTGCCTAACTTTCCCGGG | ERCC6 | ENSG00000225830 | 0.26987863974956555 | [4] | [5,6] | 7 | hSpCas9 | positive selection | 3721365 | 49483340 | 49483363 | 10 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TCATACCTGTTTGCAAGCAAGGG | ERCC6 | ENSG00000225830 | 0.03503531856007355 | [4] | [2,5] | 0 | hSpCas9 | positive selection | 3829967 | 49493148 | 49493171 | 10 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.17984012604934121 | [6] | [4,4] | -2 | hSpCas9 | positive selection | 3829968 | 49505923 | 49505946 | 10 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | AGTGATGCTGAATTTGACGAAGG | ERCC6 | ENSG00000225830 | 0.13605327343394766 | [5] | [5,4] | 3 | hSpCas9 | positive selection | 3829969 | 49482834 | 49482857 | 10 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | AGACAGAATGATCCGATGAGGGG | ERCC6 | ENSG00000225830 | -0.03586744821776408 | [5] | [3,5] | 0 | hSpCas9 | positive selection | 3829970 | 49482733 | 49482756 | 10 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | 0.12262577607068642 | [5] | [5,5] | 3 | hSpCas9 | positive selection | 3829971 | 49482755 | 49482778 | 10 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCAACGTGCCTAACTTTCCCGGG | ERCC6 | ENSG00000225830 | 0.012590412556479422 | [5] | [5,3] | 0 | hSpCas9 | positive selection | 3829972 | 49483441 | 49483463 | 10 | - | 27760321 | OCIAML3 | viability | TCCTACATTCGATTGATGCAGG | ERCC6 | ENSG00000225830 | -0.2070364747829474 | [501,432] | [314,316] | -2 | hSpCas9 | negative selection | 4398226 | 49483441 | 49483463 | 10 | - | 27760321 | OCIAML2 | viability | TCCTACATTCGATTGATGCAGG | ERCC6 | ENSG00000225830 | -0.022991669293660533 | [501,432] | [261,514] | 0 | hSpCas9 | negative selection | 4481689 | 49483441 | 49483463 | 10 | - | 27760321 | MV411 | viability | TCCTACATTCGATTGATGCAGG | ERCC6 | ENSG00000225830 | 0.016610679642668852 | [501,432] | [323,291] | 0 | hSpCas9 | negative selection | 4565152 | 49483441 | 49483463 | 10 | - | 27760321 | HL60 | viability | TCCTACATTCGATTGATGCAGG | ERCC6 | ENSG00000225830 | 0.26655266563924074 | [501,432] | [378,541] | 3 | hSpCas9 | negative selection | 4648615 | 49483441 | 49483463 | 10 | - | 27760321 | HT1080 | viability | TCCTACATTCGATTGATGCAGG | ERCC6 | ENSG00000225830 | 1.3475704545602245 | [432,337] | [523,244] | 7 | hSpCas9 | negative selection | 4732078 | 49483441 | 49483463 | 10 | - | 27760321 | HT29 | viability after 7 days | TCCTACATTCGATTGATGCAGG | ERCC6 | ENSG00000225830 | -0.3066475339919594 | [432,337] | [286,229,659] | -4 | hSpCas9 | negative selection | 4815541 | 49483441 | 49483463 | 10 | - | 27760321 | HT29 | viability after 25 days | TCCTACATTCGATTGATGCAGG | ERCC6 | ENSG00000225830 | -0.5041033359766928 | [432,337] | [316,277,338] | -5 | hSpCas9 | negative selection | 4899004 | 49483441 | 49483463 | 10 | - | 27760321 | HT29 | viability after 22 days | TCCTACATTCGATTGATGCAGG | ERCC6 | ENSG00000225830 | -0.1361499226533254 | [432,337] | [480,382,349] | -1 | hSpCas9 | negative selection | 4982467 | 49483441 | 49483463 | 10 | - | 27760321 | HT29 | viability after 19 days | TCCTACATTCGATTGATGCAGG | ERCC6 | ENSG00000225830 | -0.016717958409311576 | [432,337] | [223,223,821] | 0 | hSpCas9 | negative selection | 5065930 | 49483441 | 49483463 | 10 | - | 27760321 | HT29 | viability after 16 days | TCCTACATTCGATTGATGCAGG | ERCC6 | ENSG00000225830 | -0.3105416367479012 | [432,337] | [515,200,345] | -3 | hSpCas9 | negative selection | 5149393 | 49483441 | 49483463 | 10 | - | 27760321 | HT29 | viability after 13 days | TCCTACATTCGATTGATGCAGG | ERCC6 | ENSG00000225830 | 0.01626563359828792 | [432,337] | [562,331,460] | 0 | hSpCas9 | negative selection | 5232856 | 49483441 | 49483463 | 10 | - | 27760321 | HT29 | viability after 10 days | TCCTACATTCGATTGATGCAGG | ERCC6 | ENSG00000225830 | -0.17724283281982256 | [432,337] | [600,367,308] | -2 | hSpCas9 | negative selection | 5316319 | 49483441 | 49483463 | 10 | - | 27760321 | MOLM13 | viability | TCCTACATTCGATTGATGCAGG | ERCC6 | ENSG00000225830 | 0.6738751352912423 | [501,432] | [538,317] | 4 | hSpCas9 | negative selection | 5399782 | 49472993 | 49473016 | 10 | - | 27869803 | HPAFII | viability after 27 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 0.7808057417271322 | [280] | [357,166,NaN] | 6 | hSpCas9 | negative selection | 9538051 | 49483395 | 49483418 | 10 | - | 27869803 | HPAFII | viability after 27 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.9763140364599234 | [769] | [808,785,NaN] | 7 | hSpCas9 | negative selection | 9538052 | 49493148 | 49493171 | 10 | + | 27869803 | HPAFII | viability after 27 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.3560812736430402 | [382] | [302,219,NaN] | 3 | hSpCas9 | negative selection | 9538053 | 49500643 | 49500666 | 10 | - | 27869803 | HPAFII | viability after 27 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | 0.2713758721733337 | [99] | [99,32,NaN] | 2 | hSpCas9 | negative selection | 9538054 | 49472993 | 49473016 | 10 | - | 27869803 | HPAFII | viability after 15 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 0.6112559143447281 | [280] | [604,371,NaN] | 7 | hSpCas9 | negative selection | 9620500 | 49483395 | 49483418 | 10 | - | 27869803 | HPAFII | viability after 15 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.18788433956788508 | [769] | [1081,855,NaN] | 2 | hSpCas9 | negative selection | 9620501 | 49493148 | 49493171 | 10 | + | 27869803 | HPAFII | viability after 15 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.1889430073189402 | [382] | [668,344,NaN] | 2 | hSpCas9 | negative selection | 9620502 | 49500643 | 49500666 | 10 | - | 27869803 | HPAFII | viability after 15 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | 0.7546183251920274 | [99] | [287,114,NaN] | 8 | hSpCas9 | negative selection | 9620503 | 49472993 | 49473016 | 10 | - | 27869803 | ASPC1 | viability after 36 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | -0.36289336101402037 | [832] | [273,384,63] | -4 | hSpCas9 | negative selection | 9702949 | 49483395 | 49483418 | 10 | - | 27869803 | ASPC1 | viability after 36 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.2909565688206035 | [2256] | [966,1300,683] | 3 | hSpCas9 | negative selection | 9702950 | 49493148 | 49493171 | 10 | + | 27869803 | ASPC1 | viability after 36 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.5923695830004844 | [1073] | [549,888,312] | 6 | hSpCas9 | negative selection | 9702951 | 49500643 | 49500666 | 10 | - | 27869803 | ASPC1 | viability after 36 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | -0.14757800289486678 | [314] | [106,64,119] | -1 | hSpCas9 | negative selection | 9702952 | 49472993 | 49473016 | 10 | - | 27869803 | PATU8988S | viability after 35 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 1.0999841751007042 | [535] | [344,580,NaN] | 9 | hSpCas9 | negative selection | 9785398 | 49483395 | 49483418 | 10 | - | 27869803 | PATU8988S | viability after 35 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.21830801156820479 | [1941] | [654,1165,NaN] | 2 | hSpCas9 | negative selection | 9785399 | 49493148 | 49493171 | 10 | + | 27869803 | PATU8988S | viability after 35 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.025326439488199348 | [976] | [380,419,NaN] | 0 | hSpCas9 | negative selection | 9785400 | 49500643 | 49500666 | 10 | - | 27869803 | PATU8988S | viability after 35 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | -0.4691902433670374 | [260] | [46,104,NaN] | -5 | hSpCas9 | negative selection | 9785401 | 49472993 | 49473016 | 10 | - | 27869803 | PATU8988S | viability after 31 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 0.918986210005536 | [535] | [360,458,NaN] | 8 | hSpCas9 | negative selection | 9867847 | 49483395 | 49483418 | 10 | - | 27869803 | PATU8988S | viability after 31 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 0.33519707314637315 | [1941] | [653,1387,NaN] | 4 | hSpCas9 | negative selection | 9867848 | 49493148 | 49493171 | 10 | + | 27869803 | PATU8988S | viability after 31 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.044275596333796075 | [976] | [368,388,NaN] | 0 | hSpCas9 | negative selection | 9867849 | 49500643 | 49500666 | 10 | - | 27869803 | PATU8988S | viability after 31 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | 0.2048519059442908 | [260] | [71,180,NaN] | 2 | hSpCas9 | negative selection | 9867850 | 49472993 | 49473016 | 10 | - | 27869803 | HPAFII | viability after 35 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 0.9823726279704824 | [280] | [392,154,NaN] | 6 | hSpCas9 | negative selection | 9950296 | 49483395 | 49483418 | 10 | - | 27869803 | HPAFII | viability after 35 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 1.4326668718120752 | [769] | [889,1234,NaN] | 8 | hSpCas9 | negative selection | 9950297 | 49493148 | 49493171 | 10 | + | 27869803 | HPAFII | viability after 35 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.4157463453678917 | [382] | [134,156,NaN] | -3 | hSpCas9 | negative selection | 9950298 | 49500643 | 49500666 | 10 | - | 27869803 | HPAFII | viability after 35 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | 0.24986710990229488 | [99] | [102,11,NaN] | 1 | hSpCas9 | negative selection | 9950299 | 49472993 | 49473016 | 10 | - | 27869803 | HPAFII | viability after 31 days | TTGTGTTTCTTCTGACCACGCGG | ERCC6 | ENSG00000225830 | 1.054736426207978 | [280] | [407,239,NaN] | 7 | hSpCas9 | negative selection | 10032745 | 49483395 | 49483418 | 10 | - | 27869803 | HPAFII | viability after 31 days | CACTATGTGATCTTGGACGAAGG | ERCC6 | ENSG00000225830 | 1.0358078217156006 | [769] | [695,1092,NaN] | 7 | hSpCas9 | negative selection | 10032746 | 49493148 | 49493171 | 10 | + | 27869803 | HPAFII | viability after 31 days | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.4732398086412468 | [382] | [295,300,NaN] | 3 | hSpCas9 | negative selection | 10032747 | 49500643 | 49500666 | 10 | - | 27869803 | HPAFII | viability after 31 days | GAATTGCACTGCCAGCAGGCAGG | ERCC6 | ENSG00000225830 | 0.5147883369175069 | [99] | [128,26,NaN] | 4 | hSpCas9 | negative selection | 10032748 | 49493148 | 49493171 | 10 | + | 28162770 | P31FUJ | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -1.4150055356351274 | [58] | [25] | -7 | hSpCas9 | negative selection | 10151030 | 49482733 | 49482756 | 10 | + | 28162770 | P31FUJ | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | -1.0087619301964486 | [124] | [72] | -6 | hSpCas9 | negative selection | 10151031 | 49482798 | 49482821 | 10 | - | 28162770 | P31FUJ | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | -0.951428207877651 | [468] | [284] | -6 | hSpCas9 | negative selection | 10151032 | 49482791 | 49482814 | 10 | + | 28162770 | P31FUJ | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | -1.6113138276681083 | [12] | [4] | -7 | hSpCas9 | negative selection | 10151033 | 49493148 | 49493171 | 10 | + | 28162770 | TF1 | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | NaN | [NaN] | [54] | 1 | hSpCas9 | negative selection | 10320396 | 49482733 | 49482756 | 10 | + | 28162770 | TF1 | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | NaN | [NaN] | [51] | 1 | hSpCas9 | negative selection | 10320397 | 49482798 | 49482821 | 10 | - | 28162770 | TF1 | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | NaN | [NaN] | [374] | 1 | hSpCas9 | negative selection | 10320398 | 49482791 | 49482814 | 10 | + | 28162770 | TF1 | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | NaN | [NaN] | [0] | 1 | hSpCas9 | negative selection | 10320399 | 49493148 | 49493171 | 10 | + | 28162770 | SKM1 | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.6451243124052926 | [16] | [46] | 6 | hSpCas9 | negative selection | 10489762 | 49482733 | 49482756 | 10 | + | 28162770 | SKM1 | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | 0.13735631748064858 | [35] | [69] | 1 | hSpCas9 | negative selection | 10489763 | 49482798 | 49482821 | 10 | - | 28162770 | SKM1 | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | 0.6426665689814388 | [99] | [275] | 6 | hSpCas9 | negative selection | 10489764 | 49482791 | 49482814 | 10 | + | 28162770 | SKM1 | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | 1.052467419894135 | [2] | [10] | 8 | hSpCas9 | negative selection | 10489765 | 49493148 | 49493171 | 10 | + | 28162770 | SKM1 | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.6451243124052926 | [16] | [46] | 6 | hSpCas9 | negative selection | 10659128 | 49482733 | 49482756 | 10 | + | 28162770 | SKM1 | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | 0.13735631748064858 | [35] | [69] | 1 | hSpCas9 | negative selection | 10659129 | 49482798 | 49482821 | 10 | - | 28162770 | SKM1 | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | 0.6426665689814388 | [99] | [275] | 6 | hSpCas9 | negative selection | 10659130 | 49482791 | 49482814 | 10 | + | 28162770 | SKM1 | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | 1.052467419894135 | [2] | [10] | 8 | hSpCas9 | negative selection | 10659131 | 49493148 | 49493171 | 10 | + | 28162770 | PL21 | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.28453180177969273 | [82] | [43] | 2 | hSpCas9 | negative selection | 10828494 | 49482733 | 49482756 | 10 | + | 28162770 | PL21 | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | 0.0886312992723296 | [120] | [55] | 0 | hSpCas9 | negative selection | 10828495 | 49482798 | 49482821 | 10 | - | 28162770 | PL21 | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | -0.5208436811350308 | [388] | [117] | -4 | hSpCas9 | negative selection | 10828496 | 49482791 | 49482814 | 10 | + | 28162770 | PL21 | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | -1.3848228862318361 | [5] | [0] | -7 | hSpCas9 | negative selection | 10828497 | 49493148 | 49493171 | 10 | + | 28162770 | P31FUJ | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -1.4150055356351274 | [58] | [25] | -7 | hSpCas9 | negative selection | 10997860 | 49482733 | 49482756 | 10 | + | 28162770 | P31FUJ | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | -1.0087619301964486 | [124] | [72] | -6 | hSpCas9 | negative selection | 10997861 | 49482798 | 49482821 | 10 | - | 28162770 | P31FUJ | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | -0.951428207877651 | [468] | [284] | -6 | hSpCas9 | negative selection | 10997862 | 49482791 | 49482814 | 10 | + | 28162770 | P31FUJ | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | -1.6113138276681083 | [12] | [4] | -7 | hSpCas9 | negative selection | 10997863 | 49493148 | 49493171 | 10 | + | 28162770 | OCIAML5 | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.2995255478352181 | [29] | [43] | -2 | hSpCas9 | negative selection | 11167226 | 49482733 | 49482756 | 10 | + | 28162770 | OCIAML5 | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | 0.7640905514607536 | [60] | [186] | 6 | hSpCas9 | negative selection | 11167227 | 49482798 | 49482821 | 10 | - | 28162770 | OCIAML5 | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | 0.11936427693923224 | [254] | [499] | 1 | hSpCas9 | negative selection | 11167228 | 49482791 | 49482814 | 10 | + | 28162770 | OCIAML5 | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | -0.8520665708639967 | [0] | [0] | -5 | hSpCas9 | negative selection | 11167229 | 49493148 | 49493171 | 10 | + | 28162770 | EOL1 | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -2.2453772298717776 | [170] | [18] | -8 | hSpCas9 | negative selection | 11336592 | 49482733 | 49482756 | 10 | + | 28162770 | EOL1 | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | 0.014745580542112835 | [123] | [65] | 0 | hSpCas9 | negative selection | 11336593 | 49482798 | 49482821 | 10 | - | 28162770 | EOL1 | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | 0.5382692652731146 | [446] | [341] | 5 | hSpCas9 | negative selection | 11336594 | 49482791 | 49482814 | 10 | + | 28162770 | EOL1 | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | -0.07545222842946586 | [1] | [0] | 0 | hSpCas9 | negative selection | 11336595 | 49493148 | 49493171 | 10 | + | 28162770 | MOLM13 | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 0.44212628547949706 | [112] | [110] | 3 | hSpCas9 | negative selection | 11505958 | 49482733 | 49482756 | 10 | + | 28162770 | MOLM13 | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | -1.6916564741177345 | [276] | [61] | -7 | hSpCas9 | negative selection | 11505959 | 49482798 | 49482821 | 10 | - | 28162770 | MOLM13 | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | 0.5243621506278787 | [500] | [520] | 4 | hSpCas9 | negative selection | 11505960 | 49482791 | 49482814 | 10 | + | 28162770 | MOLM13 | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | -2.854038713342784 | [9] | [0] | -8 | hSpCas9 | negative selection | 11505961 | 49493148 | 49493171 | 10 | + | 28162770 | HEL | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 1.534679086142904 | [96] | [179] | 9 | hSpCas9 | negative selection | 11675324 | 49482733 | 49482756 | 10 | + | 28162770 | HEL | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | -0.575566631812848 | [234] | [100] | -4 | hSpCas9 | negative selection | 11675325 | 49482798 | 49482821 | 10 | - | 28162770 | HEL | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | 0.3728507551255008 | [421] | [349] | 3 | hSpCas9 | negative selection | 11675326 | 49482791 | 49482814 | 10 | + | 28162770 | HEL | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | -0.3572611679996429 | [1] | [0] | -2 | hSpCas9 | negative selection | 11675327 | 49493148 | 49493171 | 10 | + | 28162770 | MV411 | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.15973783072309788 | [60] | [45] | -1 | hSpCas9 | negative selection | 11844690 | 49482733 | 49482756 | 10 | + | 28162770 | MV411 | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | -0.23798927638746648 | [83] | [59] | -2 | hSpCas9 | negative selection | 11844691 | 49482798 | 49482821 | 10 | - | 28162770 | MV411 | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | 0.2971905859798749 | [341] | [353] | 2 | hSpCas9 | negative selection | 11844692 | 49482791 | 49482814 | 10 | + | 28162770 | MV411 | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | 2.749937891311959 | [2] | [16] | 9 | hSpCas9 | negative selection | 11844693 | 49493148 | 49493171 | 10 | + | 28162770 | MONOMAC1 | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.6495490517570603 | [51] | [37] | -5 | hSpCas9 | negative selection | 12014056 | 49482733 | 49482756 | 10 | + | 28162770 | MONOMAC1 | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | 0.9626198189289314 | [46] | [104] | 8 | hSpCas9 | negative selection | 12014057 | 49482798 | 49482821 | 10 | - | 28162770 | MONOMAC1 | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | 0.5284559626627038 | [201] | [333] | 5 | hSpCas9 | negative selection | 12014058 | 49482791 | 49482814 | 10 | + | 28162770 | MONOMAC1 | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | -3.0043917691171576 | [6] | [0] | -9 | hSpCas9 | negative selection | 12014059 | 49493148 | 49493171 | 10 | + | 28162770 | OCIAML2 | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | 1.3645593050121687 | [10] | [156] | 9 | hSpCas9 | negative selection | 12183422 | 49482733 | 49482756 | 10 | + | 28162770 | OCIAML2 | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | -0.6632749031845571 | [21] | [76] | -5 | hSpCas9 | negative selection | 12183423 | 49482798 | 49482821 | 10 | - | 28162770 | OCIAML2 | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | 0.654207286671613 | [64] | [566] | 6 | hSpCas9 | negative selection | 12183424 | 49482791 | 49482814 | 10 | + | 28162770 | OCIAML2 | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | -1.4706298252421615 | [1] | [3] | -7 | hSpCas9 | negative selection | 12183425 | 49493148 | 49493171 | 10 | + | 28162770 | OCIAML3 | viability | AGAATTGCCACTCTGAACGGAGG | ERCC6 | ENSG00000225830 | -0.5600603084008258 | [20] | [42] | -4 | hSpCas9 | negative selection | 12352788 | 49482733 | 49482756 | 10 | + | 28162770 | OCIAML3 | viability | GAGAACTGCTCCATAAACACAGG | ERCC6 | ENSG00000225830 | -0.11696047876989435 | [36] | [102] | -1 | hSpCas9 | negative selection | 12352789 | 49482798 | 49482821 | 10 | - | 28162770 | OCIAML3 | viability | AAAATAACCTCCGAGAGCTGTGG | ERCC6 | ENSG00000225830 | -0.15263599323185695 | [94] | [257] | -1 | hSpCas9 | negative selection | 12352790 | 49482791 | 49482814 | 10 | + | 28162770 | OCIAML3 | viability | AGAGCGACCACAGCTCTCGGAGG | ERCC6 | ENSG00000225830 | -1.594007640324163 | [0] | [0] | -8 | hSpCas9 | negative selection | 12352791 |