Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:2200
• Symbol:FBN1
• Description:fibrillin 1

DataSource: http://genomecrispr.dkfz.de/#!/results/FBN1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
48537668	48537691	15	+	26472758	Jiyoye	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	-0.5113970191502806	[309]	[163]	-4	hSpCas9	negative selection	56400
48498984	48499007	15	-	26472758	Jiyoye	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	-0.018130453226797183	[46]	[34]	0	hSpCas9	negative selection	56401
48470645	48470668	15	-	26472758	Jiyoye	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	-2.409517405131067	[154]	[21]	-8	hSpCas9	negative selection	56402
48644694	48644717	15	-	26472758	Jiyoye	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	-0.5352371269411829	[220]	[114]	-4	hSpCas9	negative selection	56403
48644630	48644653	15	-	26472758	Jiyoye	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	-0.722107635439093	[279]	[127]	-5	hSpCas9	negative selection	56404
48537632	48537655	15	+	26472758	Jiyoye	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	1.246710709312627	[18]	[33]	7	hSpCas9	negative selection	56405
48526134	48526157	15	+	26472758	Jiyoye	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	-1.936779019711488	[65]	[12]	-8	hSpCas9	negative selection	56406
48516278	48516301	15	+	26472758	Jiyoye	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-1.351816518990332	[43]	[12]	-7	hSpCas9	negative selection	56407
48516260	48516283	15	+	26472758	Jiyoye	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-1.762749619936439	[80]	[17]	-8	hSpCas9	negative selection	56408
48503861	48503884	15	+	26472758	Jiyoye	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	0.33678605361447544	[62]	[59]	2	hSpCas9	negative selection	56409
48537668	48537691	15	+	26472758	KBM7	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	0.3107936824241053	[830,545]	[328,453]	3	hSpCas9	negative selection	247518
48498984	48499007	15	-	26472758	KBM7	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	0.25231030263028953	[176,180]	[131,72]	2	hSpCas9	negative selection	247519
48470645	48470668	15	-	26472758	KBM7	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	0.14335644338858244	[335,165]	[145,108]	1	hSpCas9	negative selection	247520
48644694	48644717	15	-	26472758	KBM7	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	-0.2680351731819961	[524,388]	[221,135]	-3	hSpCas9	negative selection	247521
48644630	48644653	15	-	26472758	KBM7	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	0.5518984577593289	[511,426]	[374,274]	6	hSpCas9	negative selection	247522
48537632	48537655	15	+	26472758	KBM7	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	-0.6177797591149439	[130,111]	[34,38]	-5	hSpCas9	negative selection	247523
48526134	48526157	15	+	26472758	KBM7	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	0.08032781417404888	[156,260]	[58,149]	0	hSpCas9	negative selection	247524
48516278	48516301	15	+	26472758	KBM7	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-0.47814524901432676	[279,186]	[122,36]	-4	hSpCas9	negative selection	247525
48516260	48516283	15	+	26472758	KBM7	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-2.185208717304281	[502,366]	[44,43]	-8	hSpCas9	negative selection	247526
48503861	48503884	15	+	26472758	KBM7	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	0.29967747367609343	[402,342]	[202,225]	3	hSpCas9	negative selection	247527
48537668	48537691	15	+	26472758	Raji	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	0.01186092432930863	[358]	[83]	0	hSpCas9	negative selection	438636
48498984	48499007	15	-	26472758	Raji	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	0.13010361187368313	[62]	[15]	1	hSpCas9	negative selection	438637
48470645	48470668	15	-	26472758	Raji	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	0.7240548958220936	[59]	[22]	6	hSpCas9	negative selection	438638
48644694	48644717	15	-	26472758	Raji	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	1.1648690300343596	[122]	[63]	8	hSpCas9	negative selection	438639
48644630	48644653	15	-	26472758	Raji	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	-0.05343925896146044	[236]	[52]	0	hSpCas9	negative selection	438640
48537632	48537655	15	+	26472758	Raji	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	0.9954906553027022	[66]	[30]	8	hSpCas9	negative selection	438641
48526134	48526157	15	+	26472758	Raji	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	0.2879557810154203	[59]	[16]	2	hSpCas9	negative selection	438642
48516278	48516301	15	+	26472758	Raji	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-1.5171073295341941	[110]	[8]	-8	hSpCas9	negative selection	438643
48516260	48516283	15	+	26472758	Raji	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-4.239573354005286	[406]	[4]	-9	hSpCas9	negative selection	438644
48503861	48503884	15	+	26472758	Raji	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	1.3704179412073931	[179]	[107]	9	hSpCas9	negative selection	438645
48537668	48537691	15	+	26472758	K562	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	0.18859681739399237	[605]	[582]	1	hSpCas9	negative selection	629754
48498984	48499007	15	-	26472758	K562	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	0.47821591227514415	[107]	[126]	4	hSpCas9	negative selection	629755
48470645	48470668	15	-	26472758	K562	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	-0.39815449622480453	[280]	[179]	-3	hSpCas9	negative selection	629756
48644694	48644717	15	-	26472758	K562	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	0.010407223063165612	[373]	[317]	0	hSpCas9	negative selection	629757
48644630	48644653	15	-	26472758	K562	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	0.39596519979390454	[631]	[701]	3	hSpCas9	negative selection	629758
48537632	48537655	15	+	26472758	K562	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	0.5448136610041681	[107]	[132]	4	hSpCas9	negative selection	629759
48526134	48526157	15	+	26472758	K562	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	0.9813843218326531	[206]	[344]	8	hSpCas9	negative selection	629760
48516278	48516301	15	+	26472758	K562	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-5.556481172253858	[222]	[3]	-9	hSpCas9	negative selection	629761
48516260	48516283	15	+	26472758	K562	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-5.532562545347639	[328]	[5]	-9	hSpCas9	negative selection	629762
48503861	48503884	15	+	26472758	K562	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	0.1523431427680678	[371]	[348]	1	hSpCas9	negative selection	629763
48516212	48516235	15	+	26627737	DLD1	viability	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	0.046270335200759044	[505]	[97,248,148]	0	hSpCas9	negative selection	790873
48537744	48537767	15	-	26627737	DLD1	viability	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	0.08818097465526126	[632]	[31,237,341]	0	hSpCas9	negative selection	790874
48600165	48600188	15	-	26627737	DLD1	viability	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	1.2004905027221806	[216]	[221,123,124]	9	hSpCas9	negative selection	790875
48610804	48610827	15	+	26627737	DLD1	viability	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.5228934709975095	[1137]	[510,386,613]	5	hSpCas9	negative selection	790876
48613012	48613035	15	+	26627737	DLD1	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.2679361201660767	[402]	[73,199,178]	2	hSpCas9	negative selection	790877
48644736	48644759	15	-	26627737	DLD1	viability	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	1.568815245669073	[121]	[65,94,168]	9	hSpCas9	negative selection	790878
48516212	48516235	15	+	26627737	GBM cells	viability after 5 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	0.18101254234640113	[212]	[97,160]	3	hSpCas9	negative selection	873188
48537744	48537767	15	-	26627737	GBM cells	viability after 5 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	-0.5650332248741049	[279]	[85,116]	-7	hSpCas9	negative selection	873189
48600165	48600188	15	-	26627737	GBM cells	viability after 5 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	0.21953577227242319	[220]	[116,158]	3	hSpCas9	negative selection	873190
48610804	48610827	15	+	26627737	GBM cells	viability after 5 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.018584105548302032	[739]	[399,403]	0	hSpCas9	negative selection	873191
48613012	48613035	15	+	26627737	GBM cells	viability after 5 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.01196023464133078	[203]	[93,122]	0	hSpCas9	negative selection	873192
48644736	48644759	15	-	26627737	GBM cells	viability after 5 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	-0.019144511578138346	[153]	[100,61]	0	hSpCas9	negative selection	873193
48516212	48516235	15	+	26627737	GBM cells	viability after 13 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	0.5809789445031035	[212]	[200,149]	7	hSpCas9	negative selection	955503
48537744	48537767	15	-	26627737	GBM cells	viability after 13 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	0.03556787204975123	[279]	[131,174]	0	hSpCas9	negative selection	955504
48600165	48600188	15	-	26627737	GBM cells	viability after 13 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	0.2641992307747851	[220]	[159,130]	3	hSpCas9	negative selection	955505
48610804	48610827	15	+	26627737	GBM cells	viability after 13 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.18902186253186049	[739]	[433,476]	2	hSpCas9	negative selection	955506
48613012	48613035	15	+	26627737	GBM cells	viability after 13 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.18986267301210752	[203]	[101,92]	-2	hSpCas9	negative selection	955507
48644736	48644759	15	-	26627737	GBM cells	viability after 13 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	-0.25540040017148724	[153]	[69,69]	-3	hSpCas9	negative selection	955508
48516212	48516235	15	+	26627737	GBM cells	viability after 21 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	-0.2998874689325427	[212]	[93,93]	-3	hSpCas9	negative selection	1037818
48537744	48537767	15	-	26627737	GBM cells	viability after 21 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	0.6007549908532517	[279]	[237,223]	6	hSpCas9	negative selection	1037819
48600165	48600188	15	-	26627737	GBM cells	viability after 21 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	0.5633736492318127	[220]	[190,164]	6	hSpCas9	negative selection	1037820
48610804	48610827	15	+	26627737	GBM cells	viability after 21 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.13123127955960112	[739]	[432,446]	1	hSpCas9	negative selection	1037821
48613012	48613035	15	+	26627737	GBM cells	viability after 21 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.3067652151855955	[203]	[98,80]	-3	hSpCas9	negative selection	1037822
48644736	48644759	15	-	26627737	GBM cells	viability after 21 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	-0.7391747666895647	[153]	[58,41]	-6	hSpCas9	negative selection	1037823
48516212	48516235	15	+	26627737	RPE1	viability after 9 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	-0.45808658400628527	[1199]	[138,446]	-3	hSpCas9	negative selection	1120133
48537744	48537767	15	-	26627737	RPE1	viability after 9 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	1.6586344019637922	[247]	[214,283]	8	hSpCas9	negative selection	1120134
48600165	48600188	15	-	26627737	RPE1	viability after 9 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	1.6019417939729952	[316]	[271,338]	8	hSpCas9	negative selection	1120135
48610804	48610827	15	+	26627737	RPE1	viability after 9 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.7381039733549519	[1992]	[938,1171]	5	hSpCas9	negative selection	1120136
48613012	48613035	15	+	26627737	RPE1	viability after 9 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.864676034234437	[492]	[120,37]	-6	hSpCas9	negative selection	1120137
48644736	48644759	15	-	26627737	RPE1	viability after 9 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	0.160274944945215	[392]	[133,141]	1	hSpCas9	negative selection	1120138
48516212	48516235	15	+	26627737	RPE1	viability after 12 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	-0.6492113241400495	[1199]	[224,184]	-4	hSpCas9	negative selection	1202448
48537744	48537767	15	-	26627737	RPE1	viability after 12 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	1.5549415204252952	[247]	[204,185]	8	hSpCas9	negative selection	1202449
48600165	48600188	15	-	26627737	RPE1	viability after 12 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	1.2676545699606447	[316]	[172,238]	7	hSpCas9	negative selection	1202450
48610804	48610827	15	+	26627737	RPE1	viability after 12 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.797757101006654	[1992]	[737,1134]	5	hSpCas9	negative selection	1202451
48613012	48613035	15	+	26627737	RPE1	viability after 12 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.797613332098814	[492]	[99,50]	-5	hSpCas9	negative selection	1202452
48644736	48644759	15	-	26627737	RPE1	viability after 12 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	-0.08378645875373059	[392]	[86,112]	0	hSpCas9	negative selection	1202453
48516212	48516235	15	+	26627737	RPE1	viability after 15 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	-0.5988263067921699	[1199]	[131,312]	-4	hSpCas9	negative selection	1284763
48537744	48537767	15	-	26627737	RPE1	viability after 15 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	1.5596354688159504	[247]	[189,222]	8	hSpCas9	negative selection	1284764
48600165	48600188	15	-	26627737	RPE1	viability after 15 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	1.0379648540876425	[316]	[176,190]	6	hSpCas9	negative selection	1284765
48610804	48610827	15	+	26627737	RPE1	viability after 15 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.9298953666924774	[1992]	[1041,1104]	5	hSpCas9	negative selection	1284766
48613012	48613035	15	+	26627737	RPE1	viability after 15 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.05288797875118434	[492]	[165,103]	0	hSpCas9	negative selection	1284767
48644736	48644759	15	-	26627737	RPE1	viability after 15 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	-0.44358962334275753	[392]	[67,94]	-3	hSpCas9	negative selection	1284768
48516212	48516235	15	+	26627737	RPE1	viability after 18 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	-0.7510575121424226	[1199]	[87,303]	-5	hSpCas9	negative selection	1367078
48537744	48537767	15	-	26627737	RPE1	viability after 18 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	1.9192220362360053	[247]	[256,248]	8	hSpCas9	negative selection	1367079
48600165	48600188	15	-	26627737	RPE1	viability after 18 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	1.529613413602045	[316]	[231,262]	7	hSpCas9	negative selection	1367080
48610804	48610827	15	+	26627737	RPE1	viability after 18 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.9519147999840287	[1992]	[921,1166]	5	hSpCas9	negative selection	1367081
48613012	48613035	15	+	26627737	RPE1	viability after 18 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.18646315071626662	[492]	[128,103]	-1	hSpCas9	negative selection	1367082
48644736	48644759	15	-	26627737	RPE1	viability after 18 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	0.02274749436481538	[392]	[143,68]	0	hSpCas9	negative selection	1367083
48516212	48516235	15	+	26627737	HeLa	viability after 8 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	-0.09328551231099391	[459]	[148,137,261]	-1	hSpCas9	negative selection	1449393
48537744	48537767	15	-	26627737	HeLa	viability after 8 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	-0.36694258896371734	[738]	[297,140,314]	-4	hSpCas9	negative selection	1449394
48600165	48600188	15	-	26627737	HeLa	viability after 8 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	-0.07105934178955382	[413]	[194,202,124]	0	hSpCas9	negative selection	1449395
48610804	48610827	15	+	26627737	HeLa	viability after 8 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.585329552170062	[777]	[434,464,600]	5	hSpCas9	negative selection	1449396
48613012	48613035	15	+	26627737	HeLa	viability after 8 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.28027010180186407	[142]	[95,115,22]	2	hSpCas9	negative selection	1449397
48644736	48644759	15	-	26627737	HeLa	viability after 8 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	0.9611777450054704	[167]	[227,166,56]	7	hSpCas9	negative selection	1449398
48516212	48516235	15	+	26627737	HeLa	viability after 12 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	0.4300230656445361	[459]	[237,244,285]	3	hSpCas9	negative selection	1531708
48537744	48537767	15	-	26627737	HeLa	viability after 12 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	-0.8179841893095089	[738]	[179,143,198]	-6	hSpCas9	negative selection	1531709
48600165	48600188	15	-	26627737	HeLa	viability after 12 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	-0.24279395925559524	[413]	[203,120,112]	-2	hSpCas9	negative selection	1531710
48610804	48610827	15	+	26627737	HeLa	viability after 12 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.15266239925553216	[777]	[246,366,453]	1	hSpCas9	negative selection	1531711
48613012	48613035	15	+	26627737	HeLa	viability after 12 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.35270689538777633	[142]	[80,108,32]	3	hSpCas9	negative selection	1531712
48644736	48644759	15	-	26627737	HeLa	viability after 12 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	1.1111447851480372	[167]	[286,101,69]	7	hSpCas9	negative selection	1531713
48516212	48516235	15	+	26627737	HeLa	viability after 15 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	0.05014834693981876	[459]	[161,190,231]	0	hSpCas9	negative selection	1614023
48537744	48537767	15	-	26627737	HeLa	viability after 15 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	-0.5550244781893664	[738]	[163,219,232]	-5	hSpCas9	negative selection	1614024
48600165	48600188	15	-	26627737	HeLa	viability after 15 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	-0.3601338227979835	[413]	[136,159,93]	-3	hSpCas9	negative selection	1614025
48610804	48610827	15	+	26627737	HeLa	viability after 15 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.45339386913284463	[777]	[300,395,619]	4	hSpCas9	negative selection	1614026
48613012	48613035	15	+	26627737	HeLa	viability after 15 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.54891469621985	[142]	[106,101,42]	4	hSpCas9	negative selection	1614027
48644736	48644759	15	-	26627737	HeLa	viability after 15 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	1.6225383596951513	[167]	[104,270,260]	9	hSpCas9	negative selection	1614028
48516212	48516235	15	+	26627737	HeLa	viability after 18 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	0.027715330207175898	[459]	[98,162,231]	0	hSpCas9	negative selection	1696338
48537744	48537767	15	-	26627737	HeLa	viability after 18 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	-0.5997963583645258	[738]	[105,171,232]	-5	hSpCas9	negative selection	1696339
48600165	48600188	15	-	26627737	HeLa	viability after 18 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	-0.2805247477583156	[413]	[97,142,93]	-2	hSpCas9	negative selection	1696340
48610804	48610827	15	+	26627737	HeLa	viability after 18 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.47431177776398037	[777]	[202,341,619]	4	hSpCas9	negative selection	1696341
48613012	48613035	15	+	26627737	HeLa	viability after 18 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.5211263950412168	[142]	[68,83,42]	4	hSpCas9	negative selection	1696342
48644736	48644759	15	-	26627737	HeLa	viability after 18 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	1.6148842950602997	[167]	[70,220,260]	9	hSpCas9	negative selection	1696343
48516212	48516235	15	+	26627737	HCT116	viability after 6 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	0.29909510005513507	[857]	[154,171]	1	hSpCas9	negative selection	1778653
48537744	48537767	15	-	26627737	HCT116	viability after 6 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	-1.3886863304549697	[1618]	[73,109]	-7	hSpCas9	negative selection	1778654
48600165	48600188	15	-	26627737	HCT116	viability after 6 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	-0.6172919856822471	[512]	[78,37]	-4	hSpCas9	negative selection	1778655
48610804	48610827	15	+	26627737	HCT116	viability after 6 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.08178632109930928	[1762]	[496,180]	0	hSpCas9	negative selection	1778656
48613012	48613035	15	+	26627737	HCT116	viability after 6 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	1.3736733613488628	[222]	[231,12]	7	hSpCas9	negative selection	1778657
48644736	48644759	15	-	26627737	HCT116	viability after 6 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	-0.5477012113561704	[776]	[167,36]	-3	hSpCas9	negative selection	1778658
48516212	48516235	15	+	26627737	HCT116	viability after 8 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	0.3987071599393074	[251]	[179,257,111]	4	hSpCas9	negative selection	1860968
48537744	48537767	15	-	26627737	HCT116	viability after 8 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	1.1246230049474335	[203]	[289,191,253]	8	hSpCas9	negative selection	1860969
48600165	48600188	15	-	26627737	HCT116	viability after 8 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	-0.24199765731812148	[273]	[114,158,108]	-3	hSpCas9	negative selection	1860970
48610804	48610827	15	+	26627737	HCT116	viability after 8 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.2663384563196225	[669]	[476,352,501]	3	hSpCas9	negative selection	1860971
48613012	48613035	15	+	26627737	HCT116	viability after 8 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.968882007441991	[76]	[83,68,95]	8	hSpCas9	negative selection	1860972
48644736	48644759	15	-	26627737	HCT116	viability after 8 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	-0.18049928090237777	[236]	[145,63,135]	-2	hSpCas9	negative selection	1860973
48516212	48516235	15	+	26627737	HCT116	viability after 9 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	0.13872473147347508	[857]	[540,23]	1	hSpCas9	negative selection	1943283
48537744	48537767	15	-	26627737	HCT116	viability after 9 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	-0.40912420337598765	[1618]	[324,325]	-3	hSpCas9	negative selection	1943284
48600165	48600188	15	-	26627737	HCT116	viability after 9 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	0.30382309531736207	[512]	[172,165]	2	hSpCas9	negative selection	1943285
48610804	48610827	15	+	26627737	HCT116	viability after 9 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.4022154433517062	[1762]	[806,475]	3	hSpCas9	negative selection	1943286
48613012	48613035	15	+	26627737	HCT116	viability after 9 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	1.0184346370560693	[222]	[128,113]	7	hSpCas9	negative selection	1943287
48644736	48644759	15	-	26627737	HCT116	viability after 9 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	-0.9620103381534565	[776]	[53,147]	-6	hSpCas9	negative selection	1943288
48516212	48516235	15	+	26627737	HCT116	viability after 12 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	0.9169470425714915	[251]	[276,217,251]	7	hSpCas9	negative selection	2025598
48537744	48537767	15	-	26627737	HCT116	viability after 12 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	0.8746898773610775	[203]	[176,177,235]	7	hSpCas9	negative selection	2025599
48600165	48600188	15	-	26627737	HCT116	viability after 12 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	0.2303596113157001	[273]	[116,278,117]	2	hSpCas9	negative selection	2025600
48610804	48610827	15	+	26627737	HCT116	viability after 12 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.38697320589458006	[669]	[559,520,292]	4	hSpCas9	negative selection	2025601
48613012	48613035	15	+	26627737	HCT116	viability after 12 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	1.1275730671035198	[76]	[85,110,68]	8	hSpCas9	negative selection	2025602
48644736	48644759	15	-	26627737	HCT116	viability after 12 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	-0.13853377314888016	[236]	[126,103,106]	-1	hSpCas9	negative selection	2025603
48516212	48516235	15	+	26627737	HCT116	viability after 15 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	0.7536230163916375	[251]	[203,349,173]	6	hSpCas9	negative selection	2107913
48537744	48537767	15	-	26627737	HCT116	viability after 15 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	0.866254774941129	[203]	[275,216,155]	7	hSpCas9	negative selection	2107914
48600165	48600188	15	-	26627737	HCT116	viability after 15 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	0.04290190626181013	[273]	[124,210,145]	0	hSpCas9	negative selection	2107915
48610804	48610827	15	+	26627737	HCT116	viability after 15 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.3602553881003978	[669]	[598,438,456]	3	hSpCas9	negative selection	2107916
48613012	48613035	15	+	26627737	HCT116	viability after 15 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.6855764357784799	[76]	[20,92,92]	6	hSpCas9	negative selection	2107917
48644736	48644759	15	-	26627737	HCT116	viability after 15 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	0.5424908315212975	[236]	[228,215,153]	5	hSpCas9	negative selection	2107918
48516212	48516235	15	+	26627737	HCT116	viability after 18 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	0.7456506909366348	[251]	[171,275,157]	6	hSpCas9	negative selection	2190228
48537744	48537767	15	-	26627737	HCT116	viability after 18 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	1.0893491967881581	[203]	[157,252,215]	8	hSpCas9	negative selection	2190229
48600165	48600188	15	-	26627737	HCT116	viability after 18 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	0.06019804302384486	[273]	[91,176,142]	0	hSpCas9	negative selection	2190230
48610804	48610827	15	+	26627737	HCT116	viability after 18 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.27366334703725936	[669]	[563,343,263]	2	hSpCas9	negative selection	2190231
48613012	48613035	15	+	26627737	HCT116	viability after 18 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.8120955111856099	[76]	[78,68,46]	6	hSpCas9	negative selection	2190232
48644736	48644759	15	-	26627737	HCT116	viability after 18 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	-0.11590888226563645	[236]	[72,137,103]	-1	hSpCas9	negative selection	2190233
48589686	48589709	15	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCACTGCAAGCTCCACCTCCTGG	FBN1	ENSG00000166147	-1.3954490623194618	[659,580]	[75,24]	-7	dCas9-VP64	positive selection	2391156
48589686	48589709	15	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCACTGCAAGCTCCACCTCCTGG	FBN1	ENSG00000166147	0.22022123063307442	[237,267]	[67,121]	1	dCas9-VP64	positive selection	2486411
48537623	48537646	15	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CTTCATTCCAAATATCCGCACGG	FBN1	ENSG00000166147	0.3817691107217289	[3,3]	[3,4]	7	hSpCas9	positive selection	2988061
48526151	48526174	15	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGAGAGGTGTAAAAACCAGGGGG	FBN1	ENSG00000166147	-0.6765841263571801	[2,3]	[2,0]	-8	hSpCas9	positive selection	2988062
48613027	48613050	15	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGATGGAAAACCTTACCTGGCGG	FBN1	ENSG00000166147	0.13401092353197686	[5,4]	[4,4]	3	hSpCas9	positive selection	2988063
48490053	48490076	15	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TCAGGAAGCAGGTTTCCAGGCGG	FBN1	ENSG00000166147	-0.5955375985699815	[3,3]	[2,0]	-7	hSpCas9	positive selection	2988064
48537623	48537646	15	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CTTCATTCCAAATATCCGCACGG	FBN1	ENSG00000166147	-0.30539461192623596	[3,3]	[2,0]	-4	hSpCas9	positive selection	3055919
48526151	48526174	15	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGAGAGGTGTAAAAACCAGGGGG	FBN1	ENSG00000166147	-0.2596676570653768	[2,2]	[3,0]	-4	hSpCas9	positive selection	3055920
48613027	48613050	15	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGATGGAAAACCTTACCTGGCGG	FBN1	ENSG00000166147	0.3441644860439488	[5,5]	[6,2]	6	hSpCas9	positive selection	3055921
48490053	48490076	15	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TCAGGAAGCAGGTTTCCAGGCGG	FBN1	ENSG00000166147	-0.22441395874802283	[3,3]	[2,0]	-3	hSpCas9	positive selection	3055922
48613068	48613091		+	24336571	A375	resistance to PLX after 7 days	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	0.061487159242703204	[19,18]	[17,22]	2	hSpCas9	positive selection	3114132
48644699	48644722		-	24336571	A375	resistance to PLX after 7 days	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	0.03225959038495768	[8,10]	[8,11]	1	hSpCas9	positive selection	3114133
48613068	48613091		+	24336571	A375	resistance to PLX after 14 days	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.7177098538837848	[22,17]	[4,5]	-8	hSpCas9	positive selection	3171925
48644699	48644722		-	24336571	A375	resistance to PLX after 14 days	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.35620259234882373	[8,11]	[4,2]	-4	hSpCas9	positive selection	3171926
48613068	48613091		+	24336571	A375	viability after 7 days	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.02945652189638659	[20]	[19,18]	0	hSpCas9	negative selection	3229718
48644699	48644722		-	24336571	A375	viability after 7 days	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.229430637556138	[11]	[8,10]	-3	hSpCas9	negative selection	3229719
48613068	48613091		+	24336571	A375	viability after 14 days	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	0.028295243648347346	[20]	[22,17]	0	hSpCas9	negative selection	3287511
48644699	48644722		-	24336571	A375	viability after 14 days	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.10613649509979337	[11]	[8,11]	-1	hSpCas9	negative selection	3287512
48644758	48644781	15	-	27383988	293T	resistance to West Nile virus (flavivirus)	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	1.1828174170450336	[50,83]	[0,0]	5	hSpCas9	positive selection	3349608
48644699	48644722	15	-	27383988	293T	resistance to West Nile virus (flavivirus)	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	2.0863538814341953	[39,31]	[0,0]	7	hSpCas9	positive selection	3349609
48610760	48610783	15	-	27383988	293T	resistance to West Nile virus (flavivirus)	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.1271678748683159	[152,126]	[0,0]	0	hSpCas9	positive selection	3349610
48613012	48613035	15	+	27383988	293T	resistance to West Nile virus (flavivirus)	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.3351308258222454	[192,192]	[0,0]	-2	hSpCas9	positive selection	3368813
48613068	48613091	15	+	27383988	293T	resistance to West Nile virus (flavivirus)	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.01879819382840228	[154,154]	[0,0]	0	hSpCas9	positive selection	3368814
48610789	48610812	15	+	27383988	293T	resistance to West Nile virus (flavivirus)	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	-1.274055249070477	[369,369]	[0,0]	-8	hSpCas9	positive selection	3368815
48537623	48537646	15	-	26780180	HT29	viability (Avana library 4 designs)	CTTCATTCCAAATATCCGCACGG	FBN1	ENSG00000166147	1.68382973852237	[]	[]	6	hSpCas9	negative selection	3424954
48526150	48526173	15	+	26780180	HT29	viability (Avana library 4 designs)	GGAGAGGTGTAAAAACCAGGGGG	FBN1	ENSG00000166147	0.555297338485939	[]	[]	2	hSpCas9	negative selection	3424955
48613027	48613050	15	-	26780180	HT29	viability (Avana library 4 designs)	GGATGGAAAACCTTACCTGGCGG	FBN1	ENSG00000166147	0.214228073719562	[]	[]	0	hSpCas9	negative selection	3424956
48490052	48490075	15	+	26780180	HT29	viability (Avana library 4 designs)	TCAGGAAGCAGGTTTCCAGGCGG	FBN1	ENSG00000166147	1.56868981633851	[]	[]	6	hSpCas9	negative selection	3424957
48526150	48526173	15	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGAGAGGTGTAAAAACCAGGGGG	FBN1	ENSG00000166147	0.687647598042486	[]	[]	1	hSpCas9	negative selection	3506853
48490052	48490075	15	+	26780180	A375	viability (Avana lentiCRISPRv2)	TCAGGAAGCAGGTTTCCAGGCGG	FBN1	ENSG00000166147	1.4791753530564	[]	[]	2	hSpCas9	negative selection	3506854
48537623	48537646	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	CTTCATTCCAAATATCCGCACGG	FBN1	ENSG00000166147	0.24455404523762	[]	[]	0	hSpCas9	negative selection	3506855
48613027	48613050	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGATGGAAAACCTTACCTGGCGG	FBN1	ENSG00000166147	4.14019814378237	[]	[]	6	hSpCas9	negative selection	3506856
48513562	48513585	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	GATATCAGAGCACACTCACGCGG	FBN1	ENSG00000166147	-0.164466753125227	[]	[]	0	hSpCas9	negative selection	3506857
48505122	48505145	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	TTAACGAGTGTGAAACCCCTGGG	FBN1	ENSG00000166147	2.34913222726521	[]	[]	3	hSpCas9	negative selection	3506858
48526150	48526173	15	+	26780180	A375	viability (Avana lentiGuide)	GGAGAGGTGTAAAAACCAGGGGG	FBN1	ENSG00000166147	3.01103558022845	[]	[]	3	hSpCas9	negative selection	3615512
48490052	48490075	15	+	26780180	A375	viability (Avana lentiGuide)	TCAGGAAGCAGGTTTCCAGGCGG	FBN1	ENSG00000166147	2.88886236880686	[]	[]	3	hSpCas9	negative selection	3615513
48537623	48537646	15	-	26780180	A375	viability (Avana lentiGuide)	CTTCATTCCAAATATCCGCACGG	FBN1	ENSG00000166147	-4.51239061874971	[]	[]	-7	hSpCas9	negative selection	3615514
48613027	48613050	15	-	26780180	A375	viability (Avana lentiGuide)	GGATGGAAAACCTTACCTGGCGG	FBN1	ENSG00000166147	-2.83197365845028	[]	[]	-5	hSpCas9	negative selection	3615515
48513562	48513585	15	-	26780180	A375	viability (Avana lentiGuide)	GATATCAGAGCACACTCACGCGG	FBN1	ENSG00000166147	4.74974327401456	[]	[]	4	hSpCas9	negative selection	3615516
48505122	48505145	15	-	26780180	A375	viability (Avana lentiGuide)	TTAACGAGTGTGAAACCCCTGGG	FBN1	ENSG00000166147	-2.15785441527	[]	[]	-4	hSpCas9	negative selection	3615517
48526150	48526173	15	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGAGAGGTGTAAAAACCAGGGGG	FBN1	ENSG00000166147	-0.17942966811546404	[4]	[4,2]	-3	hSpCas9	positive selection	3724171
48490052	48490075	15	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TCAGGAAGCAGGTTTCCAGGCGG	FBN1	ENSG00000166147	-0.13427313573689015	[4]	[5,2]	-2	hSpCas9	positive selection	3724172
48537623	48537646	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTTCATTCCAAATATCCGCACGG	FBN1	ENSG00000166147	-0.5984379885680389	[4]	[3,2]	-7	hSpCas9	positive selection	3724173
48613027	48613050	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGATGGAAAACCTTACCTGGCGG	FBN1	ENSG00000166147	0.22828187701617172	[5]	[6,6]	6	hSpCas9	positive selection	3724174
48513562	48513585	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GATATCAGAGCACACTCACGCGG	FBN1	ENSG00000166147	0.062487137410721795	[5]	[5,4]	1	hSpCas9	positive selection	3724175
48505122	48505145	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTAACGAGTGTGAAACCCCTGGG	FBN1	ENSG00000166147	0.17335601001463663	[5]	[6,5]	5	hSpCas9	positive selection	3724176
48526150	48526173	15	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGAGAGGTGTAAAAACCAGGGGG	FBN1	ENSG00000166147	-0.05601383331933393	[5]	[4,3]	-1	hSpCas9	positive selection	3832778
48490052	48490075	15	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TCAGGAAGCAGGTTTCCAGGCGG	FBN1	ENSG00000166147	-0.547019910533872	[5]	[2,2]	-6	hSpCas9	positive selection	3832779
48537623	48537646	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTTCATTCCAAATATCCGCACGG	FBN1	ENSG00000166147	0.18008784677936346	[4]	[4,4]	4	hSpCas9	positive selection	3832780
48613027	48613050	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGATGGAAAACCTTACCTGGCGG	FBN1	ENSG00000166147	0.38306382032812414	[5]	[6,6]	9	hSpCas9	positive selection	3832781
48513562	48513585	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GATATCAGAGCACACTCACGCGG	FBN1	ENSG00000166147	-0.04342911345212268	[5]	[4,4]	0	hSpCas9	positive selection	3832782
48505122	48505145	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTAACGAGTGTGAAACCCCTGGG	FBN1	ENSG00000166147	-0.16304320118084467	[5]	[5,3]	-2	hSpCas9	positive selection	3832783
48610760	48610783	15	-	26780180	A375	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.832658746677305	[]	[]	3	hSpCas9	negative selection	3940034
48613012	48613035	15	+	26780180	A375	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	1.63825862153093	[]	[]	8	hSpCas9	negative selection	3940035
48613068	48613091	15	+	26780180	A375	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	0.775455030872565	[]	[]	3	hSpCas9	negative selection	3940036
48610789	48610812	15	+	26780180	A375	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	1.51636953936755	[]	[]	8	hSpCas9	negative selection	3940037
48644758	48644781	15	-	26780180	A375	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	1.16567738196107	[]	[]	6	hSpCas9	negative selection	3940038
48644699	48644722	15	-	26780180	A375	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	0.95882476367824	[]	[]	4	hSpCas9	negative selection	3940039
48610760	48610783	15	-	26780180	HT29	viability (GeCKOv2 library)	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	1.60786315618042	[]	[]	8	hSpCas9	negative selection	4048000
48613012	48613035	15	+	26780180	HT29	viability (GeCKOv2 library)	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	1.34368815782481	[]	[]	6	hSpCas9	negative selection	4048001
48613068	48613091	15	+	26780180	HT29	viability (GeCKOv2 library)	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	0.801501029286161	[]	[]	3	hSpCas9	negative selection	4048002
48610789	48610812	15	+	26780180	HT29	viability (GeCKOv2 library)	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	1.00281130289542	[]	[]	4	hSpCas9	negative selection	4048003
48644758	48644781	15	-	26780180	HT29	viability (GeCKOv2 library)	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	1.405096501409	[]	[]	7	hSpCas9	negative selection	4048004
48644699	48644722	15	-	26780180	HT29	viability (GeCKOv2 library)	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	1.01809519760029	[]	[]	4	hSpCas9	negative selection	4048005
48613068	48613091	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.14755797139165325	[4]	[2,2]	-3	hSpCas9	positive selection	4137126
48644699	48644722	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.07352329777037646	[3]	[2,1]	-2	hSpCas9	positive selection	4137127
48613068	48613091	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.19839656170778178	[4]	[2,0,3,0]	-3	hSpCas9	positive selection	4201148
48644699	48644722	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	0.4839098073273477	[3]	[4,2,2,0]	3	hSpCas9	positive selection	4201149
48644758	48644781	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	0.07134325187239449	[2]	[2,0]	1	hSpCas9	positive selection	4270644
48644699	48644722	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.18532732644341293	[1]	[2,0]	-4	hSpCas9	positive selection	4270645
48610760	48610783	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.1696498744597627	[3]	[3,2]	3	hSpCas9	positive selection	4270646
48613012	48613035	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.017695776671542242	[3]	[2,1]	0	hSpCas9	positive selection	4334908
48613068	48613091	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	0.3907997242493211	[2]	[3,2]	7	hSpCas9	positive selection	4334909
48610789	48610812	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.11238409002886879	[3]	[3,2]	2	hSpCas9	positive selection	4334910
48487088	48487110	15	-	27760321	OCIAML3	viability	CTACCATTCAACTCCCGATAGG	FBN1	ENSG00000166147	0.25763159476666153	[515,419]	[341,556]	3	hSpCas9	negative selection	4400471
48487143	48487165	15	+	27760321	OCIAML3	viability	AGGTTCACGCAACGGCCATTGG	FBN1	ENSG00000166147	0.46978967459034837	[516,452]	[452,616]	5	hSpCas9	negative selection	4400472
48487302	48487324	15	+	27760321	OCIAML3	viability	TTCTCCTTACCGATACACGCGG	FBN1	ENSG00000166147	0.051290607774157726	[193,196]	[53,295]	0	hSpCas9	negative selection	4400473
48510123	48510145	15	+	27760321	OCIAML3	viability	GCGTCCATTATTGCAGATCCGG	FBN1	ENSG00000166147	0.02742792276569528	[603,501]	[378,516]	0	hSpCas9	negative selection	4400474
48515467	48515489	15	-	27760321	OCIAML3	viability	TCCGCTATCTCTGTCAAAATGG	FBN1	ENSG00000166147	0.7142765835648431	[271,194]	[253,351]	8	hSpCas9	negative selection	4400475
48487088	48487110	15	-	27760321	OCIAML2	viability	CTACCATTCAACTCCCGATAGG	FBN1	ENSG00000166147	0.4097429844567457	[515,419]	[426,596]	5	hSpCas9	negative selection	4483934
48487143	48487165	15	+	27760321	OCIAML2	viability	AGGTTCACGCAACGGCCATTGG	FBN1	ENSG00000166147	0.6617199035031441	[516,452]	[504,769]	8	hSpCas9	negative selection	4483935
48487302	48487324	15	+	27760321	OCIAML2	viability	TTCTCCTTACCGATACACGCGG	FBN1	ENSG00000166147	-0.11517049332548335	[193,196]	[143,149]	-1	hSpCas9	negative selection	4483936
48510123	48510145	15	+	27760321	OCIAML2	viability	GCGTCCATTATTGCAGATCCGG	FBN1	ENSG00000166147	0.013060213405315435	[603,501]	[398,515]	0	hSpCas9	negative selection	4483937
48515467	48515489	15	-	27760321	OCIAML2	viability	TCCGCTATCTCTGTCAAAATGG	FBN1	ENSG00000166147	0.5061553795054365	[271,194]	[271,256]	7	hSpCas9	negative selection	4483938
48487088	48487110	15	-	27760321	MV411	viability	CTACCATTCAACTCCCGATAGG	FBN1	ENSG00000166147	0.8311627068287242	[515,419]	[341,853]	6	hSpCas9	negative selection	4567397
48487143	48487165	15	+	27760321	MV411	viability	AGGTTCACGCAACGGCCATTGG	FBN1	ENSG00000166147	0.3141048137423025	[516,452]	[219,662]	2	hSpCas9	negative selection	4567398
48487302	48487324	15	+	27760321	MV411	viability	TTCTCCTTACCGATACACGCGG	FBN1	ENSG00000166147	-2.5972415614498274	[193,196]	[24,15]	-9	hSpCas9	negative selection	4567399
48510123	48510145	15	+	27760321	MV411	viability	GCGTCCATTATTGCAGATCCGG	FBN1	ENSG00000166147	0.23214304869787133	[603,501]	[421,433]	1	hSpCas9	negative selection	4567400
48515467	48515489	15	-	27760321	MV411	viability	TCCGCTATCTCTGTCAAAATGG	FBN1	ENSG00000166147	0.47520773882093137	[271,194]	[215,205]	3	hSpCas9	negative selection	4567401
48487088	48487110	15	-	27760321	HL60	viability	CTACCATTCAACTCCCGATAGG	FBN1	ENSG00000166147	-0.20603264068635135	[515,419]	[336,321]	-2	hSpCas9	negative selection	4650860
48487143	48487165	15	+	27760321	HL60	viability	AGGTTCACGCAACGGCCATTGG	FBN1	ENSG00000166147	0.31379329602849937	[516,452]	[487,494]	4	hSpCas9	negative selection	4650861
48487302	48487324	15	+	27760321	HL60	viability	TTCTCCTTACCGATACACGCGG	FBN1	ENSG00000166147	-0.6067596706192764	[193,196]	[97,112]	-6	hSpCas9	negative selection	4650862
48510123	48510145	15	+	27760321	HL60	viability	GCGTCCATTATTGCAGATCCGG	FBN1	ENSG00000166147	0.20300221590328565	[603,501]	[575,455]	2	hSpCas9	negative selection	4650863
48515467	48515489	15	-	27760321	HL60	viability	TCCGCTATCTCTGTCAAAATGG	FBN1	ENSG00000166147	1.491325856774751	[271,194]	[522,538]	9	hSpCas9	negative selection	4650864
48487088	48487110	15	-	27760321	HT1080	viability	CTACCATTCAACTCCCGATAGG	FBN1	ENSG00000166147	1.3125334181829467	[419,327]	[202,552]	7	hSpCas9	negative selection	4734323
48487143	48487165	15	+	27760321	HT1080	viability	AGGTTCACGCAACGGCCATTGG	FBN1	ENSG00000166147	0.5800530178311635	[452,353]	[267,209]	3	hSpCas9	negative selection	4734324
48487302	48487324	15	+	27760321	HT1080	viability	TTCTCCTTACCGATACACGCGG	FBN1	ENSG00000166147	0.440559859939303	[196,153]	[60,131]	2	hSpCas9	negative selection	4734325
48510123	48510145	15	+	27760321	HT1080	viability	GCGTCCATTATTGCAGATCCGG	FBN1	ENSG00000166147	0.27402774308765826	[501,391]	[158,276]	1	hSpCas9	negative selection	4734326
48515467	48515489	15	-	27760321	HT1080	viability	TCCGCTATCTCTGTCAAAATGG	FBN1	ENSG00000166147	0.5869642551784493	[194,151]	[141,61]	3	hSpCas9	negative selection	4734327
48487088	48487110	15	-	27760321	HT29	viability after 7 days	CTACCATTCAACTCCCGATAGG	FBN1	ENSG00000166147	0.5003480606371135	[419,327]	[481,803,723]	7	hSpCas9	negative selection	4817786
48487143	48487165	15	+	27760321	HT29	viability after 7 days	AGGTTCACGCAACGGCCATTGG	FBN1	ENSG00000166147	0.10412160921051264	[452,353]	[630,696,360]	1	hSpCas9	negative selection	4817787
48487302	48487324	15	+	27760321	HT29	viability after 7 days	TTCTCCTTACCGATACACGCGG	FBN1	ENSG00000166147	0.3282301994953083	[196,153]	[117,234,466]	5	hSpCas9	negative selection	4817788
48510123	48510145	15	+	27760321	HT29	viability after 7 days	GCGTCCATTATTGCAGATCCGG	FBN1	ENSG00000166147	0.07421872162458809	[501,391]	[703,536,587]	1	hSpCas9	negative selection	4817789
48515467	48515489	15	-	27760321	HT29	viability after 7 days	TCCGCTATCTCTGTCAAAATGG	FBN1	ENSG00000166147	0.7890504625015131	[194,151]	[387,411,356]	9	hSpCas9	negative selection	4817790
48487088	48487110	15	-	27760321	HT29	viability after 25 days	CTACCATTCAACTCCCGATAGG	FBN1	ENSG00000166147	0.6445724053638817	[419,327]	[426,731,881]	7	hSpCas9	negative selection	4901249
48487143	48487165	15	+	27760321	HT29	viability after 25 days	AGGTTCACGCAACGGCCATTGG	FBN1	ENSG00000166147	0.3085191716822724	[452,353]	[478,532,721]	3	hSpCas9	negative selection	4901250
48487302	48487324	15	+	27760321	HT29	viability after 25 days	TTCTCCTTACCGATACACGCGG	FBN1	ENSG00000166147	0.3199697813066441	[196,153]	[213,254,287]	3	hSpCas9	negative selection	4901251
48510123	48510145	15	+	27760321	HT29	viability after 25 days	GCGTCCATTATTGCAGATCCGG	FBN1	ENSG00000166147	0.2657505604147365	[501,391]	[530,622,701]	2	hSpCas9	negative selection	4901252
48515467	48515489	15	-	27760321	HT29	viability after 25 days	TCCGCTATCTCTGTCAAAATGG	FBN1	ENSG00000166147	1.2293471582457398	[194,151]	[562,356,467]	9	hSpCas9	negative selection	4901253
48487088	48487110	15	-	27760321	HT29	viability after 22 days	CTACCATTCAACTCCCGATAGG	FBN1	ENSG00000166147	0.43974960143318675	[419,327]	[647,492,616]	5	hSpCas9	negative selection	4984712
48487143	48487165	15	+	27760321	HT29	viability after 22 days	AGGTTCACGCAACGGCCATTGG	FBN1	ENSG00000166147	0.5775292128650831	[452,353]	[666,645,776]	6	hSpCas9	negative selection	4984713
48487302	48487324	15	+	27760321	HT29	viability after 22 days	TTCTCCTTACCGATACACGCGG	FBN1	ENSG00000166147	-0.06330853076611898	[196,153]	[207,96,277]	0	hSpCas9	negative selection	4984714
48510123	48510145	15	+	27760321	HT29	viability after 22 days	GCGTCCATTATTGCAGATCCGG	FBN1	ENSG00000166147	0.2629945053657529	[501,391]	[486,745,630]	2	hSpCas9	negative selection	4984715
48515467	48515489	15	-	27760321	HT29	viability after 22 days	TCCGCTATCTCTGTCAAAATGG	FBN1	ENSG00000166147	1.1344006107184184	[194,151]	[423,484,411]	9	hSpCas9	negative selection	4984716
48487088	48487110	15	-	27760321	HT29	viability after 19 days	CTACCATTCAACTCCCGATAGG	FBN1	ENSG00000166147	0.7050326654182999	[419,327]	[829,782,499]	7	hSpCas9	negative selection	5068175
48487143	48487165	15	+	27760321	HT29	viability after 19 days	AGGTTCACGCAACGGCCATTGG	FBN1	ENSG00000166147	0.6095596945787198	[452,353]	[731,465,908]	6	hSpCas9	negative selection	5068176
48487302	48487324	15	+	27760321	HT29	viability after 19 days	TTCTCCTTACCGATACACGCGG	FBN1	ENSG00000166147	-0.018155437996977275	[196,153]	[128,412,50]	0	hSpCas9	negative selection	5068177
48510123	48510145	15	+	27760321	HT29	viability after 19 days	GCGTCCATTATTGCAGATCCGG	FBN1	ENSG00000166147	0.6455973261644161	[501,391]	[681,543,1146]	6	hSpCas9	negative selection	5068178
48515467	48515489	15	-	27760321	HT29	viability after 19 days	TCCGCTATCTCTGTCAAAATGG	FBN1	ENSG00000166147	1.3725449271696166	[194,151]	[458,343,723]	9	hSpCas9	negative selection	5068179
48487088	48487110	15	-	27760321	HT29	viability after 16 days	CTACCATTCAACTCCCGATAGG	FBN1	ENSG00000166147	0.6478777868399237	[419,327]	[397,904,632]	7	hSpCas9	negative selection	5151638
48487143	48487165	15	+	27760321	HT29	viability after 16 days	AGGTTCACGCAACGGCCATTGG	FBN1	ENSG00000166147	0.6415870230873725	[452,353]	[988,540,613]	7	hSpCas9	negative selection	5151639
48487302	48487324	15	+	27760321	HT29	viability after 16 days	TTCTCCTTACCGATACACGCGG	FBN1	ENSG00000166147	-0.05768913668379638	[196,153]	[151,246,161]	0	hSpCas9	negative selection	5151640
48510123	48510145	15	+	27760321	HT29	viability after 16 days	GCGTCCATTATTGCAGATCCGG	FBN1	ENSG00000166147	0.29004173223029833	[501,391]	[608,692,529]	3	hSpCas9	negative selection	5151641
48515467	48515489	15	-	27760321	HT29	viability after 16 days	TCCGCTATCTCTGTCAAAATGG	FBN1	ENSG00000166147	0.8324920115512743	[194,151]	[402,279,360]	8	hSpCas9	negative selection	5151642
48487088	48487110	15	-	27760321	HT29	viability after 13 days	CTACCATTCAACTCCCGATAGG	FBN1	ENSG00000166147	0.5352567130999539	[419,327]	[691,579,614]	7	hSpCas9	negative selection	5235101
48487143	48487165	15	+	27760321	HT29	viability after 13 days	AGGTTCACGCAACGGCCATTGG	FBN1	ENSG00000166147	0.22981762585482127	[452,353]	[694,359,588]	3	hSpCas9	negative selection	5235102
48487302	48487324	15	+	27760321	HT29	viability after 13 days	TTCTCCTTACCGATACACGCGG	FBN1	ENSG00000166147	-0.9114404594165177	[196,153]	[162,93,69]	-7	hSpCas9	negative selection	5235103
48510123	48510145	15	+	27760321	HT29	viability after 13 days	GCGTCCATTATTGCAGATCCGG	FBN1	ENSG00000166147	0.41301237930197116	[501,391]	[636,838,600]	5	hSpCas9	negative selection	5235104
48515467	48515489	15	-	27760321	HT29	viability after 13 days	TCCGCTATCTCTGTCAAAATGG	FBN1	ENSG00000166147	0.7921875484384697	[194,151]	[360,446,243]	9	hSpCas9	negative selection	5235105
48487088	48487110	15	-	27760321	HT29	viability after 10 days	CTACCATTCAACTCCCGATAGG	FBN1	ENSG00000166147	0.45539724863099945	[419,327]	[636,725,561]	6	hSpCas9	negative selection	5318564
48487143	48487165	15	+	27760321	HT29	viability after 10 days	AGGTTCACGCAACGGCCATTGG	FBN1	ENSG00000166147	0.6166576692383926	[452,353]	[700,794,820]	8	hSpCas9	negative selection	5318565
48487302	48487324	15	+	27760321	HT29	viability after 10 days	TTCTCCTTACCGATACACGCGG	FBN1	ENSG00000166147	-0.7628971456830991	[196,153]	[155,148,83]	-7	hSpCas9	negative selection	5318566
48510123	48510145	15	+	27760321	HT29	viability after 10 days	GCGTCCATTATTGCAGATCCGG	FBN1	ENSG00000166147	-0.023558340872723627	[501,391]	[432,657,558]	0	hSpCas9	negative selection	5318567
48515467	48515489	15	-	27760321	HT29	viability after 10 days	TCCGCTATCTCTGTCAAAATGG	FBN1	ENSG00000166147	0.7990139781265384	[194,151]	[319,450,361]	9	hSpCas9	negative selection	5318568
48487088	48487110	15	-	27760321	MOLM13	viability	CTACCATTCAACTCCCGATAGG	FBN1	ENSG00000166147	0.483783648653362	[515,419]	[355,376]	3	hSpCas9	negative selection	5402027
48487143	48487165	15	+	27760321	MOLM13	viability	AGGTTCACGCAACGGCCATTGG	FBN1	ENSG00000166147	0.1523926604372061	[516,452]	[128,451]	1	hSpCas9	negative selection	5402028
48487302	48487324	15	+	27760321	MOLM13	viability	TTCTCCTTACCGATACACGCGG	FBN1	ENSG00000166147	1.1179439734519243	[193,196]	[208,266]	7	hSpCas9	negative selection	5402029
48510123	48510145	15	+	27760321	MOLM13	viability	GCGTCCATTATTGCAGATCCGG	FBN1	ENSG00000166147	-0.5247313783252634	[603,501]	[357,94]	-3	hSpCas9	negative selection	5402030
48515467	48515489	15	-	27760321	MOLM13	viability	TCCGCTATCTCTGTCAAAATGG	FBN1	ENSG00000166147	0.6017414453642083	[271,194]	[360,58]	4	hSpCas9	negative selection	5402031
48645584	48645607	15	+	27661255	K562	viability	GGCGGCTCCGACTCCCGAGGAGG	FBN1	ENSG00000166147	-0.04908242418889655	[878,942]	[783,632]	-2	dCas9-KRAB	negative selection	5479603
48645297	48645320	15	-	27661255	K562	viability	GGCTTCCAGCCTGGCGGAGAGGG	FBN1	ENSG00000166147	0.21692621731234651	[302,430]	[350,327]	7	dCas9-KRAB	negative selection	5479604
48645336	48645359	15	-	27661255	K562	viability	GCGGTGGCATCGCCCGGAGTCGG	FBN1	ENSG00000166147	-0.08338761505360069	[683,959]	[622,609]	-3	dCas9-KRAB	negative selection	5479605
48645632	48645655	15	-	27661255	K562	viability	GAGCCGAGCAGTGGCTGTAGCGG	FBN1	ENSG00000166147	0.19233758158344405	[344,409]	[309,371]	6	dCas9-KRAB	negative selection	5479606
48645686	48645709	15	-	27661255	K562	viability	GAGACTGTGGGTGCCACAAGCGG	FBN1	ENSG00000166147	-0.034860471507114466	[1230,1099]	[915,905]	-1	dCas9-KRAB	negative selection	5479607
48645699	48645722	15	-	27661255	K562	viability	GGGAGCCGCGGCAGAGACTGTGG	FBN1	ENSG00000166147	0.1396248105322126	[878,1004]	[908,756]	5	dCas9-KRAB	negative selection	5479608
48644758	48644781	15	-	27260156	BXPC3	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.08737844569843611	[212]	[164,299,173,194]	-2	hSpCas9	negative selection	5543104
48644699	48644722	15	-	27260156	BXPC3	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.05736534172157115	[183]	[113,216,227,185]	-1	hSpCas9	negative selection	5543105
48610760	48610783	15	-	27260156	BXPC3	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	-0.060489096003235904	[527]	[509,491,506,619]	-1	hSpCas9	negative selection	5543106
48613012	48613035	15	+	27260156	BXPC3	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.06915827412041567	[481]	[441,537,510,420]	-2	hSpCas9	negative selection	5607368
48613068	48613091	15	+	27260156	BXPC3	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.034623072985316306	[378]	[295,430,397,432]	-1	hSpCas9	negative selection	5607369
48610789	48610812	15	+	27260156	BXPC3	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.23499246568506182	[663]	[740,950,806,755]	5	hSpCas9	negative selection	5607370
48644758	48644781	15	-	27260156	A673	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.0469891470590762	[212]	[293,172,219,313]	-1	hSpCas9	negative selection	5664355
48644699	48644722	15	-	27260156	A673	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.44867841300004185	[183]	[199,171,113,165]	-8	hSpCas9	negative selection	5664356
48610760	48610783	15	-	27260156	A673	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.004732253707655731	[527]	[770,455,636,702]	0	hSpCas9	negative selection	5664357
48613012	48613035	15	+	27260156	A673	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.0757107613056422	[481]	[556,497,525,620]	-2	hSpCas9	negative selection	5728619
48613068	48613091	15	+	27260156	A673	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.2575524303608496	[378]	[488,290,358,398]	-6	hSpCas9	negative selection	5728620
48610789	48610812	15	+	27260156	A673	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.1347730696629329	[663]	[1033,853,808,818]	3	hSpCas9	negative selection	5728621
48644758	48644781	15	-	27260156	A375	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	0.1554693154473552	[212]	[301,230,308,260]	2	hSpCas9	negative selection	5785606
48644699	48644722	15	-	27260156	A375	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.30415928793111147	[183]	[133,152,181,217]	-4	hSpCas9	negative selection	5785607
48610760	48610783	15	-	27260156	A375	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.3167905132858484	[527]	[708,534,814,954]	4	hSpCas9	negative selection	5785608
48613012	48613035	15	+	27260156	A375	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.2302762305101195	[481]	[483,517,909,700]	3	hSpCas9	negative selection	5849870
48613068	48613091	15	+	27260156	A375	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.43626240799885796	[378]	[298,540,207,292]	-6	hSpCas9	negative selection	5849871
48610789	48610812	15	+	27260156	A375	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.10535984923305797	[663]	[887,811,1154,514]	1	hSpCas9	negative selection	5849872
48644758	48644781	15	-	27260156	COLO741	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.029383435803086222	[212]	[290,251,258]	0	hSpCas9	negative selection	5906857
48644699	48644722	15	-	27260156	COLO741	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.3686462986534198	[183]	[223,110,211]	-7	hSpCas9	negative selection	5906858
48610760	48610783	15	-	27260156	COLO741	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.06211649735231359	[527]	[782,743,598]	1	hSpCas9	negative selection	5906859
48613012	48613035	15	+	27260156	COLO741	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.11035888014063557	[481]	[590,662,465]	-2	hSpCas9	negative selection	5971121
48613068	48613091	15	+	27260156	COLO741	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	0.2988287256928232	[378]	[568,847,382]	6	hSpCas9	negative selection	5971122
48610789	48610812	15	+	27260156	COLO741	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	-0.25876094038979647	[663]	[864,625,651]	-5	hSpCas9	negative selection	5971123
48644758	48644781	15	-	27260156	CAL120	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.21246176169648434	[212]	[233,169,281]	-3	hSpCas9	negative selection	6028108
48644699	48644722	15	-	27260156	CAL120	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.6596718934270065	[183]	[193,150,97]	-7	hSpCas9	negative selection	6028109
48610760	48610783	15	-	27260156	CAL120	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	-0.06016592587862564	[527]	[550,561,762]	-1	hSpCas9	negative selection	6028110
48613012	48613035	15	+	27260156	CAL120	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.3707991426160798	[481]	[660,1030,619]	5	hSpCas9	negative selection	6092372
48613068	48613091	15	+	27260156	CAL120	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.025858687490907584	[378]	[566,589,251]	0	hSpCas9	negative selection	6092373
48610789	48610812	15	+	27260156	CAL120	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.14208650809517465	[663]	[878,767,1079]	2	hSpCas9	negative selection	6092374
48644758	48644781	15	-	27260156	CADOES1	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.3242755192346012	[212]	[139,88,188,216]	-5	hSpCas9	negative selection	6149359
48644699	48644722	15	-	27260156	CADOES1	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.6994364704802267	[183]	[125,61,86,147]	-8	hSpCas9	negative selection	6149360
48610760	48610783	15	-	27260156	CADOES1	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.25529127792047157	[527]	[602,588,425,731]	4	hSpCas9	negative selection	6149361
48613012	48613035	15	+	27260156	CADOES1	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.2346392393957943	[481]	[571,541,538,453]	4	hSpCas9	negative selection	6213623
48613068	48613091	15	+	27260156	CADOES1	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.3116683205583004	[378]	[386,211,191,346]	-5	hSpCas9	negative selection	6213624
48610789	48610812	15	+	27260156	CADOES1	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	-0.039749160996019106	[663]	[627,543,474,761]	0	hSpCas9	negative selection	6213625
48644758	48644781	15	-	27260156	EWS502	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	0.2864914583298874	[212]	[331,319,230,201]	5	hSpCas9	negative selection	6270610
48644699	48644722	15	-	27260156	EWS502	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.43182351905974214	[183]	[136,125,161,154]	-6	hSpCas9	negative selection	6270611
48610760	48610783	15	-	27260156	EWS502	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.28269309558231703	[527]	[672,688,805,542]	5	hSpCas9	negative selection	6270612
48613012	48613035	15	+	27260156	EWS502	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.0117426396953642	[481]	[388,676,508,451]	0	hSpCas9	negative selection	6334874
48613068	48613091	15	+	27260156	EWS502	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.31985871230031104	[378]	[448,195,253,378]	-5	hSpCas9	negative selection	6334875
48610789	48610812	15	+	27260156	EWS502	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	-0.08847030547623408	[663]	[536,725,727,665]	-2	hSpCas9	negative selection	6334876
48644758	48644781	15	-	27260156	EW8	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.12552562851607174	[212]	[190,216,107,128]	-2	hSpCas9	negative selection	6391861
48644699	48644722	15	-	27260156	EW8	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.39077336296379994	[183]	[254,90,55,77]	-6	hSpCas9	negative selection	6391862
48610760	48610783	15	-	27260156	EW8	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.0014603434107864355	[527]	[476,497,326,432]	0	hSpCas9	negative selection	6391863
48613012	48613035	15	+	27260156	EW8	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.0042471360206579115	[481]	[391,417,252,516]	0	hSpCas9	negative selection	6456125
48613068	48613091	15	+	27260156	EW8	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.5907792571642616	[378]	[289,133,181,221]	-8	hSpCas9	negative selection	6456126
48610789	48610812	15	+	27260156	EW8	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	-0.015963344926126943	[663]	[682,495,495,474]	0	hSpCas9	negative selection	6456127
48644758	48644781	15	-	27260156	CORL105	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.11938594730652552	[212]	[268,228,237,184]	-2	hSpCas9	negative selection	6513112
48644699	48644722	15	-	27260156	CORL105	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	0.003757063273318817	[183]	[248,196,144,262]	0	hSpCas9	negative selection	6513113
48610760	48610783	15	-	27260156	CORL105	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.30590661840570343	[527]	[802,734,706,803]	6	hSpCas9	negative selection	6513114
48613012	48613035	15	+	27260156	CORL105	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.16875661275292125	[481]	[624,698,686,532]	3	hSpCas9	negative selection	6577376
48613068	48613091	15	+	27260156	CORL105	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.4374690279801354	[378]	[376,260,237,422]	-7	hSpCas9	negative selection	6577377
48610789	48610812	15	+	27260156	CORL105	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.12713758171381673	[663]	[949,639,863,950]	2	hSpCas9	negative selection	6577378
48644758	48644781	15	-	27260156	HS294T	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	0.613435726863865	[212]	[71,154,63,234]	7	hSpCas9	negative selection	6634363
48644699	48644722	15	-	27260156	HS294T	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.5246175443256582	[183]	[46,48,56,43]	-6	hSpCas9	negative selection	6634364
48610760	48610783	15	-	27260156	HS294T	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.8922198105932913	[527]	[254,295,280,760]	9	hSpCas9	negative selection	6634365
48613012	48613035	15	+	27260156	HS294T	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.11615959111598394	[481]	[139,147,161,254]	-2	hSpCas9	negative selection	6698627
48613068	48613091	15	+	27260156	HS294T	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.12285562479075951	[378]	[85,153,146,158]	-2	hSpCas9	negative selection	6698628
48610789	48610812	15	+	27260156	HS294T	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.2613787085684065	[663]	[369,317,204,334]	3	hSpCas9	negative selection	6698629
48644758	48644781	15	-	27260156	HCC44	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	0.07983093510146388	[212]	[240,235,240,295]	1	hSpCas9	negative selection	6755614
48644699	48644722	15	-	27260156	HCC44	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.34603413088223056	[183]	[104,184,307,74]	-5	hSpCas9	negative selection	6755615
48610760	48610783	15	-	27260156	HCC44	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.21151065974989933	[527]	[845,529,911,551]	3	hSpCas9	negative selection	6755616
48613012	48613035	15	+	27260156	HCC44	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.024430518667164988	[481]	[592,345,888,408]	0	hSpCas9	negative selection	6819878
48613068	48613091	15	+	27260156	HCC44	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.6510515779302112	[378]	[238,285,291,270]	-7	hSpCas9	negative selection	6819879
48610789	48610812	15	+	27260156	HCC44	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	-0.31757970412316827	[663]	[483,541,784,622]	-5	hSpCas9	negative selection	6819880
48644758	48644781	15	-	27260156	G402	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	0.9959380104405847	[212]	[1042,250,221,610]	9	hSpCas9	negative selection	6876865
48644699	48644722	15	-	27260156	G402	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.7775364562815406	[183]	[61,147,100,199]	-7	hSpCas9	negative selection	6876866
48610760	48610783	15	-	27260156	G402	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.7563318673155079	[527]	[1140,1439,792,1006]	8	hSpCas9	negative selection	6876867
48613012	48613035	15	+	27260156	G402	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.42556934538120395	[481]	[1370,799,467,610]	5	hSpCas9	negative selection	6941129
48613068	48613091	15	+	27260156	G402	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.8980961382863807	[378]	[385,349,86,196]	-8	hSpCas9	negative selection	6941130
48610789	48610812	15	+	27260156	G402	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	-0.28779418129350115	[663]	[828,542,674,623]	-4	hSpCas9	negative selection	6941131
48644758	48644781	15	-	27260156	L33	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	0.24600083134702433	[212]	[242,150,116,212]	5	hSpCas9	negative selection	6998116
48644699	48644722	15	-	27260156	L33	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.40215749806354695	[183]	[117,54,94,153]	-7	hSpCas9	negative selection	6998117
48610760	48610783	15	-	27260156	L33	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.6054615913825011	[527]	[800,317,591,695]	9	hSpCas9	negative selection	6998118
48613012	48613035	15	+	27260156	L33	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.03651460728563059	[481]	[532,230,257,468]	0	hSpCas9	negative selection	7062380
48613068	48613091	15	+	27260156	L33	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	0.11741753967542518	[378]	[331,185,274,422]	2	hSpCas9	negative selection	7062381
48610789	48610812	15	+	27260156	L33	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	-0.048750073151008655	[663]	[732,317,355,490]	-1	hSpCas9	negative selection	7062382
48644758	48644781	15	-	27260156	K562	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	0.6109049816268564	[212]	[134,188,412,386]	7	hSpCas9	negative selection	7119367
48644699	48644722	15	-	27260156	K562	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.5432966486382935	[183]	[55,168,107,112]	-6	hSpCas9	negative selection	7119368
48610760	48610783	15	-	27260156	K562	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.20299502085891116	[527]	[828,493,441,424]	2	hSpCas9	negative selection	7119369
48613012	48613035	15	+	27260156	K562	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.37505571736043	[481]	[451,196,559,134]	-4	hSpCas9	negative selection	7183631
48613068	48613091	15	+	27260156	K562	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.49720867687989434	[378]	[281,325,129,223]	-5	hSpCas9	negative selection	7183632
48610789	48610812	15	+	27260156	K562	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.1799209166265503	[663]	[785,638,578,670]	2	hSpCas9	negative selection	7183633
48644758	48644781	15	-	27260156	HT29	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.08529291723632904	[212]	[341,237,224,183]	-2	hSpCas9	negative selection	7240618
48644699	48644722	15	-	27260156	HT29	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.2544281007818272	[183]	[215,193,212,134]	-5	hSpCas9	negative selection	7240619
48610760	48610783	15	-	27260156	HT29	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.08634997670382663	[527]	[970,550,574,639]	1	hSpCas9	negative selection	7240620
48613012	48613035	15	+	27260156	HT29	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.25650714800989893	[481]	[898,835,497,600]	5	hSpCas9	negative selection	7304882
48613068	48613091	15	+	27260156	HT29	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.3744727679567412	[378]	[468,259,482,223]	-6	hSpCas9	negative selection	7304883
48610789	48610812	15	+	27260156	HT29	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.2690726245205042	[663]	[1022,938,1007,920]	5	hSpCas9	negative selection	7304884
48644758	48644781	15	-	27260156	MHHES1	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.13868210733078046	[212]	[258,209,251,162]	-3	hSpCas9	negative selection	7361869
48644699	48644722	15	-	27260156	MHHES1	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.22990269846745126	[183]	[209,200,202,110]	-4	hSpCas9	negative selection	7361870
48610760	48610783	15	-	27260156	MHHES1	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.1910928790215112	[527]	[666,770,660,621]	3	hSpCas9	negative selection	7361871
48613012	48613035	15	+	27260156	MHHES1	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.11756838404143968	[481]	[526,639,403,447]	-2	hSpCas9	negative selection	7426133
48613068	48613091	15	+	27260156	MHHES1	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.13898984163982586	[378]	[482,423,281,370]	-3	hSpCas9	negative selection	7426134
48610789	48610812	15	+	27260156	MHHES1	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.2899220734600787	[663]	[1184,1327,732,549]	5	hSpCas9	negative selection	7426135
48644758	48644781	15	-	27260156	MEWO	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	0.05309848275283491	[212]	[220,196,204]	1	hSpCas9	negative selection	7483120
48644699	48644722	15	-	27260156	MEWO	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.6562893382743806	[183]	[85,140,95]	-8	hSpCas9	negative selection	7483121
48610760	48610783	15	-	27260156	MEWO	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.43965908633536155	[527]	[590,970,430]	8	hSpCas9	negative selection	7483122
48613012	48613035	15	+	27260156	MEWO	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.05628119150236399	[481]	[558,467,396]	1	hSpCas9	negative selection	7547384
48613068	48613091	15	+	27260156	MEWO	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	0.10256418120700692	[378]	[502,322,339]	2	hSpCas9	negative selection	7547385
48610789	48610812	15	+	27260156	MEWO	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	-0.1392450270035358	[663]	[773,506,451]	-3	hSpCas9	negative selection	7547386
48644758	48644781	15	-	27260156	LNCAPCLONEFGC	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.12938679884605864	[212]	[145,141,281,153]	-2	hSpCas9	negative selection	7604371
48644699	48644722	15	-	27260156	LNCAPCLONEFGC	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.16383836821162068	[183]	[57,250,161,120]	-3	hSpCas9	negative selection	7604372
48610760	48610783	15	-	27260156	LNCAPCLONEFGC	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.11671875833402426	[527]	[368,598,628,490]	1	hSpCas9	negative selection	7604373
48613012	48613035	15	+	27260156	LNCAPCLONEFGC	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.0743800761390105	[481]	[409,328,727,420]	1	hSpCas9	negative selection	7668635
48613068	48613091	15	+	27260156	LNCAPCLONEFGC	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.4341679889575847	[378]	[209,258,275,274]	-6	hSpCas9	negative selection	7668636
48610789	48610812	15	+	27260156	LNCAPCLONEFGC	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	-0.09661706053202074	[663]	[628,532,714,395]	-1	hSpCas9	negative selection	7668637
48644758	48644781	15	-	27260156	PANC0327	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	0.49901474110723154	[212]	[128,356,441,118]	7	hSpCas9	negative selection	7725622
48644699	48644722	15	-	27260156	PANC0327	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.40249354602918475	[183]	[146,79,71,202]	-5	hSpCas9	negative selection	7725623
48610760	48610783	15	-	27260156	PANC0327	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.14926008916973812	[527]	[658,587,431,403]	2	hSpCas9	negative selection	7725624
48613012	48613035	15	+	27260156	PANC0327	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.5827265859025129	[481]	[498,371,801,914]	8	hSpCas9	negative selection	7789886
48613068	48613091	15	+	27260156	PANC0327	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.5272965374758585	[378]	[205,263,172,284]	-6	hSpCas9	negative selection	7789887
48610789	48610812	15	+	27260156	PANC0327	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.16412534674614887	[663]	[643,678,788,527]	2	hSpCas9	negative selection	7789888
48644758	48644781	15	-	27260156	NCIH2009	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.11452287886185908	[212]	[262,320,236]	-1	hSpCas9	negative selection	7846873
48644699	48644722	15	-	27260156	NCIH2009	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.7963920263440207	[183]	[136,182,120]	-7	hSpCas9	negative selection	7846874
48610760	48610783	15	-	27260156	NCIH2009	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.3743857078538203	[527]	[1138,972,790]	5	hSpCas9	negative selection	7846875
48613012	48613035	15	+	27260156	NCIH2009	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.0732935318841695	[481]	[903,598,661]	1	hSpCas9	negative selection	7911137
48613068	48613091	15	+	27260156	NCIH2009	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.31909635209006004	[378]	[477,270,536]	-4	hSpCas9	negative selection	7911138
48610789	48610812	15	+	27260156	NCIH2009	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.060887121627529295	[663]	[1235,939,778]	0	hSpCas9	negative selection	7911139
48644758	48644781	15	-	27260156	NCIH1373	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.02066129028111119	[212]	[186,308,217,54]	0	hSpCas9	negative selection	7968124
48644699	48644722	15	-	27260156	NCIH1373	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.914536242845255	[183]	[77,147,105,24]	-7	hSpCas9	negative selection	7968125
48610760	48610783	15	-	27260156	NCIH1373	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.23286304691865276	[527]	[1008,606,555,174]	2	hSpCas9	negative selection	7968126
48613012	48613035	15	+	27260156	NCIH1373	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.12436065582557282	[481]	[891,338,262,150]	-1	hSpCas9	negative selection	8032388
48613068	48613091	15	+	27260156	NCIH1373	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-1.301097439772378	[378]	[253,96,81,74]	-8	hSpCas9	negative selection	8032389
48610789	48610812	15	+	27260156	NCIH1373	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	-0.06254890618700842	[663]	[1296,436,669,145]	0	hSpCas9	negative selection	8032390
48644758	48644781	15	-	27260156	PATU8902	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	0.5775039537776074	[212]	[446,337,381,638]	6	hSpCas9	negative selection	8089375
48644699	48644722	15	-	27260156	PATU8902	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.027607067679987995	[183]	[218,636,49,137]	0	hSpCas9	negative selection	8089376
48610760	48610783	15	-	27260156	PATU8902	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.941848223768353	[527]	[1922,1139,1401,1135]	8	hSpCas9	negative selection	8089377
48613012	48613035	15	+	27260156	PATU8902	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.24721160980556509	[481]	[602,1124,732,731]	2	hSpCas9	negative selection	8153639
48613068	48613091	15	+	27260156	PATU8902	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-1.2328609268717958	[378]	[230,233,117,356]	-8	hSpCas9	negative selection	8153640
48610789	48610812	15	+	27260156	PATU8902	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.24770682309409375	[663]	[1203,1367,645,1306]	2	hSpCas9	negative selection	8153641
48644758	48644781	15	-	27260156	PANC1	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.001003778590701776	[212]	[253,311,123,79]	0	hSpCas9	negative selection	8210626
48644699	48644722	15	-	27260156	PANC1	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.44195657971378655	[183]	[141,179,107,55]	-6	hSpCas9	negative selection	8210627
48610760	48610783	15	-	27260156	PANC1	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.4500777733922696	[527]	[599,570,604,672]	7	hSpCas9	negative selection	8210628
48613012	48613035	15	+	27260156	PANC1	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.2464508744274955	[481]	[354,577,463,566]	4	hSpCas9	negative selection	8274890
48613068	48613091	15	+	27260156	PANC1	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.023509610806745962	[378]	[468,345,238,236]	0	hSpCas9	negative selection	8274891
48610789	48610812	15	+	27260156	PANC1	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.0668001445870593	[663]	[613,630,533,604]	1	hSpCas9	negative selection	8274892
48644758	48644781	15	-	27260156	PANC0813	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	0.24079328323918625	[212]	[323,192,369,297]	4	hSpCas9	negative selection	8331877
48644699	48644722	15	-	27260156	PANC0813	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.1767451529987325	[183]	[158,177,288,138]	-3	hSpCas9	negative selection	8331878
48610760	48610783	15	-	27260156	PANC0813	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.5835704458377851	[527]	[1109,981,714,924]	8	hSpCas9	negative selection	8331879
48613012	48613035	15	+	27260156	PANC0813	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.06828751074291277	[481]	[614,678,451,425]	-1	hSpCas9	negative selection	8396141
48613068	48613091	15	+	27260156	PANC0813	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.3402350490116255	[378]	[343,272,285,493]	-5	hSpCas9	negative selection	8396142
48610789	48610812	15	+	27260156	PANC0813	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.2163038247613991	[663]	[827,885,1043,860]	3	hSpCas9	negative selection	8396143
48644758	48644781	15	-	27260156	RDES	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	0.07132024823950522	[212]	[168,269,285,326]	1	hSpCas9	negative selection	8453128
48644699	48644722	15	-	27260156	RDES	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.5320491811468095	[183]	[120,157,127,182]	-7	hSpCas9	negative selection	8453129
48610760	48610783	15	-	27260156	RDES	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.21155452143165684	[527]	[574,622,702,965]	3	hSpCas9	negative selection	8453130
48613012	48613035	15	+	27260156	RDES	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.07540558577775865	[481]	[423,546,608,813]	1	hSpCas9	negative selection	8517392
48613068	48613091	15	+	27260156	RDES	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.4817567708201965	[378]	[299,307,241,401]	-7	hSpCas9	negative selection	8517393
48610789	48610812	15	+	27260156	RDES	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.04958452567639737	[663]	[712,598,946,941]	0	hSpCas9	negative selection	8517394
48644758	48644781	15	-	27260156	PC3	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.013392600095227802	[212]	[105,230,510,134]	0	hSpCas9	negative selection	8574379
48644699	48644722	15	-	27260156	PC3	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	0.2830881951374693	[183]	[239,131,264,234]	6	hSpCas9	negative selection	8574380
48610760	48610783	15	-	27260156	PC3	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.11658970905941676	[527]	[480,515,876,493]	2	hSpCas9	negative selection	8574381
48613012	48613035	15	+	27260156	PC3	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.07876466718241108	[481]	[240,447,912,674]	1	hSpCas9	negative selection	8638643
48613068	48613091	15	+	27260156	PC3	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.15096299121193835	[378]	[225,380,447,360]	-3	hSpCas9	negative selection	8638644
48610789	48610812	15	+	27260156	PC3	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	-0.12299818361130321	[663]	[387,532,1062,667]	-3	hSpCas9	negative selection	8638645
48644758	48644781	15	-	27260156	PATU8988T	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.3674327996012805	[212]	[132,215,132,161]	-6	hSpCas9	negative selection	8695630
48644699	48644722	15	-	27260156	PATU8988T	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.8894383565985398	[183]	[86,88,130,73]	-8	hSpCas9	negative selection	8695631
48610760	48610783	15	-	27260156	PATU8988T	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	-0.029787885285469134	[527]	[530,496,472,497]	0	hSpCas9	negative selection	8695632
48613012	48613035	15	+	27260156	PATU8988T	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.07155594714725044	[481]	[357,429,462,526]	-1	hSpCas9	negative selection	8759894
48613068	48613091	15	+	27260156	PATU8988T	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.21461992057720425	[378]	[265,469,353,174]	-4	hSpCas9	negative selection	8759895
48610789	48610812	15	+	27260156	PATU8988T	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.021953539368698705	[663]	[478,855,638,650]	0	hSpCas9	negative selection	8759896
48644758	48644781	15	-	27260156	T47D	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.13011033499861924	[212]	[278,187,229,212]	-3	hSpCas9	negative selection	8816881
48644699	48644722	15	-	27260156	T47D	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.45198731322995034	[183]	[205,136,151,132]	-7	hSpCas9	negative selection	8816882
48610760	48610783	15	-	27260156	T47D	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.13896756273738478	[527]	[729,599,717,666]	3	hSpCas9	negative selection	8816883
48613012	48613035	15	+	27260156	T47D	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.15964506361842162	[481]	[625,542,628,720]	3	hSpCas9	negative selection	8881145
48613068	48613091	15	+	27260156	T47D	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.3121583799894653	[378]	[384,367,375,289]	-6	hSpCas9	negative selection	8881146
48610789	48610812	15	+	27260156	T47D	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.02932318863120076	[663]	[731,707,872,851]	0	hSpCas9	negative selection	8881147
48644758	48644781	15	-	27260156	SU8686	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	0.1988099357472507	[212]	[162,199,300,334]	3	hSpCas9	negative selection	8938132
48644699	48644722	15	-	27260156	SU8686	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.7400009129323242	[183]	[103,123,136,62]	-8	hSpCas9	negative selection	8938133
48610760	48610783	15	-	27260156	SU8686	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.4262789632737216	[527]	[755,523,726,841]	7	hSpCas9	negative selection	8938134
48613012	48613035	15	+	27260156	SU8686	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.029458857056073616	[481]	[261,357,582,753]	0	hSpCas9	negative selection	9002396
48613068	48613091	15	+	27260156	SU8686	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.2609130300030419	[378]	[255,321,329,356]	-4	hSpCas9	negative selection	9002397
48610789	48610812	15	+	27260156	SU8686	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.30416026655300776	[663]	[902,826,682,816]	5	hSpCas9	negative selection	9002398
48644758	48644781	15	-	27260156	SKES1	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.019464826913260236	[212]	[284,172,218,169]	0	hSpCas9	negative selection	9059383
48644699	48644722	15	-	27260156	SKES1	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.10345558504427599	[183]	[157,191,156,174]	-2	hSpCas9	negative selection	9059384
48610760	48610783	15	-	27260156	SKES1	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	-0.154026843885849	[527]	[699,485,366,380]	-3	hSpCas9	negative selection	9059385
48613012	48613035	15	+	27260156	SKES1	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.07965199857824966	[481]	[681,472,462,437]	1	hSpCas9	negative selection	9123647
48613068	48613091	15	+	27260156	SKES1	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.2339578426186446	[378]	[425,386,329,178]	-5	hSpCas9	negative selection	9123648
48610789	48610812	15	+	27260156	SKES1	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.04423644132131632	[663]	[906,781,560,536]	1	hSpCas9	negative selection	9123649
48644758	48644781	15	-	27260156	TOV112D	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.003200741499530535	[212]	[293,224,168,173]	0	hSpCas9	negative selection	9180634
48644699	48644722	15	-	27260156	TOV112D	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	0.018444506593334742	[183]	[86,322,229,132]	0	hSpCas9	negative selection	9180635
48610760	48610783	15	-	27260156	TOV112D	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.23851772163514137	[527]	[816,496,448,713]	4	hSpCas9	negative selection	9180636
48613012	48613035	15	+	27260156	TOV112D	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.1436541637816075	[481]	[635,511,501,486]	2	hSpCas9	negative selection	9244898
48613068	48613091	15	+	27260156	TOV112D	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	0.08917991138696582	[378]	[409,494,347,384]	1	hSpCas9	negative selection	9244899
48610789	48610812	15	+	27260156	TOV112D	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	-0.17919023997069589	[663]	[747,520,574,503]	-4	hSpCas9	negative selection	9244900
48644758	48644781	15	-	27260156	TC71	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	-0.11859417418748985	[212]	[213,226,217,179]	-3	hSpCas9	negative selection	9301885
48644699	48644722	15	-	27260156	TC71	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	0.00020386204476485759	[183]	[270,161,174,178]	0	hSpCas9	negative selection	9301886
48610760	48610783	15	-	27260156	TC71	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.12038597802895953	[527]	[518,722,549,676]	3	hSpCas9	negative selection	9301887
48613012	48613035	15	+	27260156	TC71	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.08981990005597093	[481]	[598,645,536,407]	2	hSpCas9	negative selection	9366149
48613068	48613091	15	+	27260156	TC71	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.26169011289897626	[378]	[445,246,307,353]	-6	hSpCas9	negative selection	9366150
48610789	48610812	15	+	27260156	TC71	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	-0.17839005555626214	[663]	[654,554,612,696]	-5	hSpCas9	negative selection	9366151
48644758	48644781	15	-	27260156	TC32	viability	GGCTCGGCATCATGCGTCGAGGG	FBN1	ENSG00000166147	0.46663181907938867	[212]	[247,293,290,252]	7	hSpCas9	negative selection	9423136
48644699	48644722	15	-	27260156	TC32	viability	TTAGCGTCCTACACGAGCCATGG	FBN1	ENSG00000166147	-0.733674280869403	[183]	[120,54,184,77]	-9	hSpCas9	negative selection	9423137
48610760	48610783	15	-	27260156	TC32	viability	AATATGTGCACTTGCCCATCTGG	FBN1	ENSG00000166147	0.07368025175408399	[527]	[547,443,615,487]	1	hSpCas9	negative selection	9423138
48613012	48613035	15	+	27260156	TC32	viability	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.024497595437031505	[481]	[493,318,522,543]	0	hSpCas9	negative selection	9487400
48613068	48613091	15	+	27260156	TC32	viability	ATAACGTGATCCACAGACATTGG	FBN1	ENSG00000166147	-0.37122246038259876	[378]	[286,96,399,397]	-6	hSpCas9	negative selection	9487401
48610789	48610812	15	+	27260156	TC32	viability	CGAACAAAATCCATCCCCACAGG	FBN1	ENSG00000166147	0.13242535518444742	[663]	[762,527,877,601]	2	hSpCas9	negative selection	9487402
48516212	48516235	15	+	27869803	HPAFII	viability after 27 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	0.7068685166781735	[181]	[159,152,NaN]	6	hSpCas9	negative selection	9553879
48537744	48537767	15	-	27869803	HPAFII	viability after 27 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	0.21586608028453058	[380]	[68,368,NaN]	1	hSpCas9	negative selection	9553880
48600165	48600188	15	-	27869803	HPAFII	viability after 27 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	0.32612983086597824	[175]	[67,155,NaN]	2	hSpCas9	negative selection	9553881
48610804	48610827	15	+	27869803	HPAFII	viability after 27 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	1.1040841543927233	[525]	[450,713,NaN]	8	hSpCas9	negative selection	9553882
48613012	48613035	15	+	27869803	HPAFII	viability after 27 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.053111336459562564	[125]	[71,65,NaN]	0	hSpCas9	negative selection	9553883
48644736	48644759	15	-	27869803	HPAFII	viability after 27 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	-0.10677105041507362	[169]	[154,22,NaN]	-1	hSpCas9	negative selection	9553884
48516212	48516235	15	+	27869803	HPAFII	viability after 15 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	-0.10677802966321193	[181]	[320,94,NaN]	-1	hSpCas9	negative selection	9636328
48537744	48537767	15	-	27869803	HPAFII	viability after 15 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	-0.19940568522642016	[380]	[318,379,NaN]	-2	hSpCas9	negative selection	9636329
48600165	48600188	15	-	27869803	HPAFII	viability after 15 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	0.5520559968511888	[175]	[420,187,NaN]	6	hSpCas9	negative selection	9636330
48610804	48610827	15	+	27869803	HPAFII	viability after 15 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.5205705396369564	[525]	[953,721,NaN]	6	hSpCas9	negative selection	9636331
48613012	48613035	15	+	27869803	HPAFII	viability after 15 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.14085370710611778	[125]	[189,123,NaN]	1	hSpCas9	negative selection	9636332
48644736	48644759	15	-	27869803	HPAFII	viability after 15 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	-0.21752734228203485	[169]	[322,53,NaN]	-3	hSpCas9	negative selection	9636333
48516212	48516235	15	+	27869803	ASPC1	viability after 36 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	0.9079416672148584	[484]	[254,181,465]	8	hSpCas9	negative selection	9718777
48537744	48537767	15	-	27869803	ASPC1	viability after 36 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	0.02812664101172646	[734]	[436,370,48]	0	hSpCas9	negative selection	9718778
48600165	48600188	15	-	27869803	ASPC1	viability after 36 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	0.2548241781460285	[447]	[111,178,242]	2	hSpCas9	negative selection	9718779
48610804	48610827	15	+	27869803	ASPC1	viability after 36 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	-0.41159889564385577	[1339]	[190,417,407]	-4	hSpCas9	negative selection	9718780
48613012	48613035	15	+	27869803	ASPC1	viability after 36 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.2848134209275618	[423]	[237,18,265]	3	hSpCas9	negative selection	9718781
48644736	48644759	15	-	27869803	ASPC1	viability after 36 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	-0.0241990055439395	[422]	[38,186,184]	0	hSpCas9	negative selection	9718782
48516212	48516235	15	+	27869803	PATU8988S	viability after 35 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	-0.4928162170286202	[541]	[209,99,NaN]	-5	hSpCas9	negative selection	9801226
48537744	48537767	15	-	27869803	PATU8988S	viability after 35 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	-0.5899661837071817	[601]	[194,126,NaN]	-5	hSpCas9	negative selection	9801227
48600165	48600188	15	-	27869803	PATU8988S	viability after 35 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	-0.0050463360676036295	[378]	[199,103,NaN]	0	hSpCas9	negative selection	9801228
48610804	48610827	15	+	27869803	PATU8988S	viability after 35 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	1.0817725235940259	[1119]	[854,1054,NaN]	9	hSpCas9	negative selection	9801229
48613012	48613035	15	+	27869803	PATU8988S	viability after 35 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.02839268653195659	[251]	[107,98,NaN]	0	hSpCas9	negative selection	9801230
48644736	48644759	15	-	27869803	PATU8988S	viability after 35 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	-0.22298622666152407	[453]	[227,84,NaN]	-2	hSpCas9	negative selection	9801231
48516212	48516235	15	+	27869803	PATU8988S	viability after 31 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	-0.12078438752279287	[541]	[207,186,NaN]	-1	hSpCas9	negative selection	9883675
48537744	48537767	15	-	27869803	PATU8988S	viability after 31 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	-0.6343455204611422	[601]	[173,129,NaN]	-6	hSpCas9	negative selection	9883676
48600165	48600188	15	-	27869803	PATU8988S	viability after 31 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	0.06609752091300203	[378]	[199,104,NaN]	0	hSpCas9	negative selection	9883677
48610804	48610827	15	+	27869803	PATU8988S	viability after 31 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.8962627815530262	[1119]	[711,982,NaN]	8	hSpCas9	negative selection	9883678
48613012	48613035	15	+	27869803	PATU8988S	viability after 31 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.3787675305143323	[251]	[82,69,NaN]	-4	hSpCas9	negative selection	9883679
48644736	48644759	15	-	27869803	PATU8988S	viability after 31 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	-0.053401194557986975	[453]	[228,104,NaN]	0	hSpCas9	negative selection	9883680
48516212	48516235	15	+	27869803	HPAFII	viability after 35 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	0.17889472767979298	[181]	[116,89,NaN]	1	hSpCas9	negative selection	9966124
48537744	48537767	15	-	27869803	HPAFII	viability after 35 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	0.6968196260659095	[380]	[68,586,NaN]	4	hSpCas9	negative selection	9966125
48600165	48600188	15	-	27869803	HPAFII	viability after 35 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	0.7334581993010665	[175]	[70,234,NaN]	5	hSpCas9	negative selection	9966126
48610804	48610827	15	+	27869803	HPAFII	viability after 35 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	1.0744775303795184	[525]	[366,778,NaN]	7	hSpCas9	negative selection	9966127
48613012	48613035	15	+	27869803	HPAFII	viability after 35 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	0.01758220568025015	[125]	[25,107,NaN]	0	hSpCas9	negative selection	9966128
48644736	48644759	15	-	27869803	HPAFII	viability after 35 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	0.36361591428221574	[169]	[161,52,NaN]	2	hSpCas9	negative selection	9966129
48516212	48516235	15	+	27869803	HPAFII	viability after 31 days	TCCACTGGTGGTCGAGGGACCGG	FBN1	ENSG00000166147	-0.06445324490112381	[181]	[123,68,NaN]	0	hSpCas9	negative selection	10048573
48537744	48537767	15	-	27869803	HPAFII	viability after 31 days	TGTGCCAGGGACAACTCAGCGGG	FBN1	ENSG00000166147	0.058496656792284996	[380]	[58,400,NaN]	0	hSpCas9	negative selection	10048574
48600165	48600188	15	-	27869803	HPAFII	viability after 31 days	GATCACTGTCTATGCCAGAAAGG	FBN1	ENSG00000166147	-0.05273783379675767	[175]	[77,113,NaN]	0	hSpCas9	negative selection	10048575
48610804	48610827	15	+	27869803	HPAFII	viability after 31 days	CCCACAGGAATGCCGGCAAATGG	FBN1	ENSG00000166147	0.8461855310931368	[525]	[333,744,NaN]	6	hSpCas9	negative selection	10048576
48613012	48613035	15	+	27869803	HPAFII	viability after 31 days	ACAATACACTGATTTCCGCCAGG	FBN1	ENSG00000166147	-0.0802825216576123	[125]	[41,93,NaN]	0	hSpCas9	negative selection	10048577
48644736	48644759	15	-	27869803	HPAFII	viability after 31 days	GCGTCTGCTGGAGATCGCCCTGG	FBN1	ENSG00000166147	0.28480121045008944	[169]	[165,61,NaN]	2	hSpCas9	negative selection	10048578
48537668	48537691	15	+	28162770	P31FUJ	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	0.12240204534728205	[239]	[306]	1	hSpCas9	negative selection	10155673
48498984	48499007	15	-	28162770	P31FUJ	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	1.3197388186144003	[44]	[131]	9	hSpCas9	negative selection	10155674
48470645	48470668	15	-	28162770	P31FUJ	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	0.26315529024803275	[77]	[109]	3	hSpCas9	negative selection	10155675
48644694	48644717	15	-	28162770	P31FUJ	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	0.3521602963067776	[105]	[158]	4	hSpCas9	negative selection	10155676
48644630	48644653	15	-	28162770	P31FUJ	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	-0.14810503983909723	[214]	[227]	-1	hSpCas9	negative selection	10155677
48537632	48537655	15	+	28162770	P31FUJ	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	0.24585139416043678	[60]	[84]	2	hSpCas9	negative selection	10155678
48526134	48526157	15	+	28162770	P31FUJ	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	-0.8281813210808733	[138]	[91]	-6	hSpCas9	negative selection	10155679
48516278	48516301	15	+	28162770	P31FUJ	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-1.3415785503317101	[178]	[82]	-7	hSpCas9	negative selection	10155680
48516260	48516283	15	+	28162770	P31FUJ	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-2.9208581980996384	[231]	[35]	-9	hSpCas9	negative selection	10155681
48503861	48503884	15	+	28162770	P31FUJ	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	0.4050121785725126	[267]	[416]	4	hSpCas9	negative selection	10155682
48537668	48537691	15	+	28162770	TF1	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	NaN	[NaN]	[290]	1	hSpCas9	negative selection	10325039
48498984	48499007	15	-	28162770	TF1	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	NaN	[NaN]	[98]	1	hSpCas9	negative selection	10325040
48470645	48470668	15	-	28162770	TF1	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	NaN	[NaN]	[0]	1	hSpCas9	negative selection	10325041
48644694	48644717	15	-	28162770	TF1	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	NaN	[NaN]	[62]	1	hSpCas9	negative selection	10325042
48644630	48644653	15	-	28162770	TF1	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	NaN	[NaN]	[136]	1	hSpCas9	negative selection	10325043
48537632	48537655	15	+	28162770	TF1	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	NaN	[NaN]	[36]	1	hSpCas9	negative selection	10325044
48526134	48526157	15	+	28162770	TF1	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	NaN	[NaN]	[111]	1	hSpCas9	negative selection	10325045
48516278	48516301	15	+	28162770	TF1	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	NaN	[NaN]	[8]	1	hSpCas9	negative selection	10325046
48516260	48516283	15	+	28162770	TF1	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	NaN	[NaN]	[6]	1	hSpCas9	negative selection	10325047
48503861	48503884	15	+	28162770	TF1	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	NaN	[NaN]	[211]	1	hSpCas9	negative selection	10325048
48537668	48537691	15	+	28162770	SKM1	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	0.4756788506186795	[71]	[176]	4	hSpCas9	negative selection	10494405
48498984	48499007	15	-	28162770	SKM1	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	0.29347551939793015	[17]	[38]	3	hSpCas9	negative selection	10494406
48470645	48470668	15	-	28162770	SKM1	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	1.1214147736116271	[12]	[49]	9	hSpCas9	negative selection	10494407
48644694	48644717	15	-	28162770	SKM1	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	0.6550454635322632	[36]	[102]	6	hSpCas9	negative selection	10494408
48644630	48644653	15	-	28162770	SKM1	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	0.32483969030726567	[55]	[123]	3	hSpCas9	negative selection	10494409
48537632	48537655	15	+	28162770	SKM1	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	0.9149638961442006	[8]	[29]	8	hSpCas9	negative selection	10494410
48526134	48526157	15	+	28162770	SKM1	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	0.92645953498203	[24]	[83]	8	hSpCas9	negative selection	10494411
48516278	48516301	15	+	28162770	SKM1	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-2.121561979880913	[31]	[12]	-8	hSpCas9	negative selection	10494412
48516260	48516283	15	+	28162770	SKM1	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-2.47735352663456	[62]	[19]	-9	hSpCas9	negative selection	10494413
48503861	48503884	15	+	28162770	SKM1	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	-0.8551685619572047	[43]	[42]	-6	hSpCas9	negative selection	10494414
48537668	48537691	15	+	28162770	SKM1	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	0.4756788506186795	[71]	[176]	4	hSpCas9	negative selection	10663771
48498984	48499007	15	-	28162770	SKM1	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	0.29347551939793015	[17]	[38]	3	hSpCas9	negative selection	10663772
48470645	48470668	15	-	28162770	SKM1	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	1.1214147736116271	[12]	[49]	9	hSpCas9	negative selection	10663773
48644694	48644717	15	-	28162770	SKM1	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	0.6550454635322632	[36]	[102]	6	hSpCas9	negative selection	10663774
48644630	48644653	15	-	28162770	SKM1	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	0.32483969030726567	[55]	[123]	3	hSpCas9	negative selection	10663775
48537632	48537655	15	+	28162770	SKM1	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	0.9149638961442006	[8]	[29]	8	hSpCas9	negative selection	10663776
48526134	48526157	15	+	28162770	SKM1	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	0.92645953498203	[24]	[83]	8	hSpCas9	negative selection	10663777
48516278	48516301	15	+	28162770	SKM1	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-2.121561979880913	[31]	[12]	-8	hSpCas9	negative selection	10663778
48516260	48516283	15	+	28162770	SKM1	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-2.47735352663456	[62]	[19]	-9	hSpCas9	negative selection	10663779
48503861	48503884	15	+	28162770	SKM1	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	-0.8551685619572047	[43]	[42]	-6	hSpCas9	negative selection	10663780
48537668	48537691	15	+	28162770	PL21	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	-0.12421114266489774	[297]	[118]	-1	hSpCas9	negative selection	10833137
48498984	48499007	15	-	28162770	PL21	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	0.6022380580606659	[55]	[36]	5	hSpCas9	negative selection	10833138
48470645	48470668	15	-	28162770	PL21	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	-0.668615852232427	[83]	[22]	-5	hSpCas9	negative selection	10833139
48644694	48644717	15	-	28162770	PL21	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	0.28894888144717623	[125]	[66]	2	hSpCas9	negative selection	10833140
48644630	48644653	15	-	28162770	PL21	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	0.6049813466622755	[212]	[140]	5	hSpCas9	negative selection	10833141
48537632	48537655	15	+	28162770	PL21	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	-1.2592920041479772	[65]	[11]	-7	hSpCas9	negative selection	10833142
48526134	48526157	15	+	28162770	PL21	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	1.1360092770696046	[68]	[65]	8	hSpCas9	negative selection	10833143
48516278	48516301	15	+	28162770	PL21	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-1.2973600449814964	[95]	[16]	-7	hSpCas9	negative selection	10833144
48516260	48516283	15	+	28162770	PL21	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-2.2454198295664196	[206]	[18]	-8	hSpCas9	negative selection	10833145
48503861	48503884	15	+	28162770	PL21	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	0.505765897047582	[177]	[109]	4	hSpCas9	negative selection	10833146
48537668	48537691	15	+	28162770	P31FUJ	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	0.12240204534728205	[239]	[306]	1	hSpCas9	negative selection	11002503
48498984	48499007	15	-	28162770	P31FUJ	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	1.3197388186144003	[44]	[131]	9	hSpCas9	negative selection	11002504
48470645	48470668	15	-	28162770	P31FUJ	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	0.26315529024803275	[77]	[109]	3	hSpCas9	negative selection	11002505
48644694	48644717	15	-	28162770	P31FUJ	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	0.3521602963067776	[105]	[158]	4	hSpCas9	negative selection	11002506
48644630	48644653	15	-	28162770	P31FUJ	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	-0.14810503983909723	[214]	[227]	-1	hSpCas9	negative selection	11002507
48537632	48537655	15	+	28162770	P31FUJ	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	0.24585139416043678	[60]	[84]	2	hSpCas9	negative selection	11002508
48526134	48526157	15	+	28162770	P31FUJ	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	-0.8281813210808733	[138]	[91]	-6	hSpCas9	negative selection	11002509
48516278	48516301	15	+	28162770	P31FUJ	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-1.3415785503317101	[178]	[82]	-7	hSpCas9	negative selection	11002510
48516260	48516283	15	+	28162770	P31FUJ	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-2.9208581980996384	[231]	[35]	-9	hSpCas9	negative selection	11002511
48503861	48503884	15	+	28162770	P31FUJ	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	0.4050121785725126	[267]	[416]	4	hSpCas9	negative selection	11002512
48537668	48537691	15	+	28162770	OCIAML5	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	0.44439083650724726	[159]	[392]	4	hSpCas9	negative selection	11171869
48498984	48499007	15	-	28162770	OCIAML5	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	1.4299687968998525	[21]	[106]	9	hSpCas9	negative selection	11171870
48470645	48470668	15	-	28162770	OCIAML5	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	-0.8993722856423537	[61]	[59]	-5	hSpCas9	negative selection	11171871
48644694	48644717	15	-	28162770	OCIAML5	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	0.2953637927912289	[78]	[174]	2	hSpCas9	negative selection	11171872
48644630	48644653	15	-	28162770	OCIAML5	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	1.1769958947384658	[85]	[350]	8	hSpCas9	negative selection	11171873
48537632	48537655	15	+	28162770	OCIAML5	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	1.8483731472770952	[9]	[64]	9	hSpCas9	negative selection	11171874
48526134	48526157	15	+	28162770	OCIAML5	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	-0.6714943252221761	[89]	[101]	-4	hSpCas9	negative selection	11171875
48516278	48516301	15	+	28162770	OCIAML5	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-1.926067152307774	[119]	[56]	-7	hSpCas9	negative selection	11171876
48516260	48516283	15	+	28162770	OCIAML5	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-4.826071362331052	[109]	[6]	-9	hSpCas9	negative selection	11171877
48503861	48503884	15	+	28162770	OCIAML5	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	0.6640969328718554	[135]	[388]	6	hSpCas9	negative selection	11171878
48537668	48537691	15	+	28162770	EOL1	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	0.41542902883288435	[527]	[370]	4	hSpCas9	negative selection	11341235
48498984	48499007	15	-	28162770	EOL1	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	-1.162915069679805	[84]	[19]	-7	hSpCas9	negative selection	11341236
48470645	48470668	15	-	28162770	EOL1	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	-0.6696332591800002	[156]	[51]	-5	hSpCas9	negative selection	11341237
48644694	48644717	15	-	28162770	EOL1	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	0.5954241752789684	[200]	[159]	5	hSpCas9	negative selection	11341238
48644630	48644653	15	-	28162770	EOL1	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	0.09751048365123055	[368]	[207]	0	hSpCas9	negative selection	11341239
48537632	48537655	15	+	28162770	EOL1	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	0.6407548055699432	[111]	[91]	6	hSpCas9	negative selection	11341240
48526134	48526157	15	+	28162770	EOL1	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	-0.11984634778791903	[98]	[47]	-1	hSpCas9	negative selection	11341241
48516278	48516301	15	+	28162770	EOL1	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-0.8690013509620391	[155]	[44]	-6	hSpCas9	negative selection	11341242
48516260	48516283	15	+	28162770	EOL1	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-0.024378043835196372	[221]	[114]	0	hSpCas9	negative selection	11341243
48503861	48503884	15	+	28162770	EOL1	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	1.152353689093347	[227]	[266]	8	hSpCas9	negative selection	11341244
48537668	48537691	15	+	28162770	MOLM13	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	0.17548037357727142	[386]	[315]	1	hSpCas9	negative selection	11510601
48498984	48499007	15	-	28162770	MOLM13	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	0.5503515417365519	[84]	[89]	4	hSpCas9	negative selection	11510602
48470645	48470668	15	-	28162770	MOLM13	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	0.27119747053948084	[101]	[88]	2	hSpCas9	negative selection	11510603
48644694	48644717	15	-	28162770	MOLM13	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	1.29385998176953	[131]	[233]	8	hSpCas9	negative selection	11510604
48644630	48644653	15	-	28162770	MOLM13	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	0.41784869904498345	[263]	[254]	3	hSpCas9	negative selection	11510605
48537632	48537655	15	+	28162770	MOLM13	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	0.3524121641246427	[77]	[71]	2	hSpCas9	negative selection	11510606
48526134	48526157	15	+	28162770	MOLM13	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	-0.10941954663314202	[93]	[62]	0	hSpCas9	negative selection	11510607
48516278	48516301	15	+	28162770	MOLM13	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-1.3097181971189733	[143]	[41]	-6	hSpCas9	negative selection	11510608
48516260	48516283	15	+	28162770	MOLM13	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-2.7020356198977336	[215]	[23]	-8	hSpCas9	negative selection	11510609
48503861	48503884	15	+	28162770	MOLM13	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	-0.20804677922406778	[269]	[168]	-1	hSpCas9	negative selection	11510610
48537668	48537691	15	+	28162770	HEL	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	0.6784730437335704	[318]	[326]	6	hSpCas9	negative selection	11679967
48498984	48499007	15	-	28162770	HEL	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	0.6427388320003571	[38]	[38]	5	hSpCas9	negative selection	11679968
48470645	48470668	15	-	28162770	HEL	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	0.4760889625909055	[109]	[97]	4	hSpCas9	negative selection	11679969
48644694	48644717	15	-	28162770	HEL	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	0.28428486108788054	[149]	[116]	2	hSpCas9	negative selection	11679970
48644630	48644653	15	-	28162770	HEL	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	0.3681164518913512	[224]	[185]	3	hSpCas9	negative selection	11679971
48537632	48537655	15	+	28162770	HEL	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	-1.1044950976196761	[93]	[27]	-6	hSpCas9	negative selection	11679972
48526134	48526157	15	+	28162770	HEL	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	-0.009337864579336275	[109]	[69]	0	hSpCas9	negative selection	11679973
48516278	48516301	15	+	28162770	HEL	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-2.7926473126702893	[118]	[10]	-8	hSpCas9	negative selection	11679974
48516260	48516283	15	+	28162770	HEL	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-1.9539054737684343	[247]	[40]	-8	hSpCas9	negative selection	11679975
48503861	48503884	15	+	28162770	HEL	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	-0.333802195175654	[243]	[123]	-2	hSpCas9	negative selection	11679976
48537668	48537691	15	+	28162770	MV411	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	0.21978120787990985	[315]	[309]	2	hSpCas9	negative selection	11849333
48498984	48499007	15	-	28162770	MV411	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	1.6518278058621108	[33]	[89]	9	hSpCas9	negative selection	11849334
48470645	48470668	15	-	28162770	MV411	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	0.6737023054848732	[63]	[85]	6	hSpCas9	negative selection	11849335
48644694	48644717	15	-	28162770	MV411	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	1.2927615412922655	[93]	[193]	9	hSpCas9	negative selection	11849336
48644630	48644653	15	-	28162770	MV411	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	-0.16243824338028975	[185]	[139]	-1	hSpCas9	negative selection	11849337
48537632	48537655	15	+	28162770	MV411	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	0.21995681436066827	[52]	[51]	2	hSpCas9	negative selection	11849338
48526134	48526157	15	+	28162770	MV411	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	0.6151693352832623	[92]	[119]	5	hSpCas9	negative selection	11849339
48516278	48516301	15	+	28162770	MV411	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-1.862186940391723	[81]	[18]	-8	hSpCas9	negative selection	11849340
48516260	48516283	15	+	28162770	MV411	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-0.9112601952362829	[191]	[85]	-6	hSpCas9	negative selection	11849341
48503861	48503884	15	+	28162770	MV411	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	0.7942253484777031	[216]	[316]	7	hSpCas9	negative selection	11849342
48537668	48537691	15	+	28162770	MONOMAC1	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	-0.7564642556735723	[195]	[132]	-6	hSpCas9	negative selection	12018699
48498984	48499007	15	-	28162770	MONOMAC1	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	1.053506614591043	[28]	[68]	8	hSpCas9	negative selection	12018700
48470645	48470668	15	-	28162770	MONOMAC1	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	0.06947812750920179	[68]	[82]	0	hSpCas9	negative selection	12018701
48644694	48644717	15	-	28162770	MONOMAC1	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	0.1835671551554161	[105]	[137]	1	hSpCas9	negative selection	12018702
48644630	48644653	15	-	28162770	MONOMAC1	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	0.019281059867209877	[135]	[157]	0	hSpCas9	negative selection	12018703
48537632	48537655	15	+	28162770	MONOMAC1	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	-0.584059970168801	[33]	[25]	-5	hSpCas9	negative selection	12018704
48526134	48526157	15	+	28162770	MONOMAC1	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	-0.2597726024075162	[46]	[44]	-2	hSpCas9	negative selection	12018705
48516278	48516301	15	+	28162770	MONOMAC1	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-1.0595333233096187	[79]	[43]	-7	hSpCas9	negative selection	12018706
48516260	48516283	15	+	28162770	MONOMAC1	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-0.4498029174395205	[111]	[93]	-4	hSpCas9	negative selection	12018707
48503861	48503884	15	+	28162770	MONOMAC1	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	0.3246607602035861	[100]	[144]	3	hSpCas9	negative selection	12018708
48537668	48537691	15	+	28162770	OCIAML2	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	0.5075658044394902	[49]	[393]	5	hSpCas9	negative selection	12188065
48498984	48499007	15	-	28162770	OCIAML2	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	-1.3331263014922263	[9]	[21]	-7	hSpCas9	negative selection	12188066
48470645	48470668	15	-	28162770	OCIAML2	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	-1.0921182019884315	[19]	[51]	-6	hSpCas9	negative selection	12188067
48644694	48644717	15	-	28162770	OCIAML2	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	0.20911090023109488	[26]	[172]	2	hSpCas9	negative selection	12188068
48644630	48644653	15	-	28162770	OCIAML2	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	1.0176566560673215	[35]	[403]	8	hSpCas9	negative selection	12188069
48537632	48537655	15	+	28162770	OCIAML2	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	-1.1487017303547988	[11]	[29]	-6	hSpCas9	negative selection	12188070
48526134	48526157	15	+	28162770	OCIAML2	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	-0.040641984497345796	[17]	[96]	0	hSpCas9	negative selection	12188071
48516278	48516301	15	+	28162770	OCIAML2	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-2.651202070883982	[16]	[14]	-9	hSpCas9	negative selection	12188072
48516260	48516283	15	+	28162770	OCIAML2	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-0.4706298252421611	[32]	[131]	-4	hSpCas9	negative selection	12188073
48503861	48503884	15	+	28162770	OCIAML2	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	0.8184668771778287	[39]	[390]	7	hSpCas9	negative selection	12188074
48537668	48537691	15	+	28162770	OCIAML3	viability	GGGCAGGACACATCTCACAGGGG	FBN1	ENSG00000166147	-0.25111992680115475	[81]	[207]	-2	hSpCas9	negative selection	12357431
48498984	48499007	15	-	28162770	OCIAML3	viability	GGAATGACGTCAGCAGGCAGTGG	FBN1	ENSG00000166147	-0.7639326417664754	[17]	[31]	-5	hSpCas9	negative selection	12357432
48470645	48470668	15	-	28162770	OCIAML3	viability	TACGAACTGGACAGAAGCGGCGG	FBN1	ENSG00000166147	0.1944882544821252	[32]	[113]	1	hSpCas9	negative selection	12357433
48644694	48644717	15	-	28162770	OCIAML3	viability	GTCCTACACGAGCCATGGGGCGG	FBN1	ENSG00000166147	-1.0514804059234035	[45]	[66]	-6	hSpCas9	negative selection	12357434
48644630	48644653	15	-	28162770	OCIAML3	viability	AGTCGGGCCAAGAGAAGAGGCGG	FBN1	ENSG00000166147	0.32026248564995297	[51]	[195]	3	hSpCas9	negative selection	12357435
48537632	48537655	15	+	28162770	OCIAML3	viability	TATTTGGAATGAAGCCACGGCGG	FBN1	ENSG00000166147	0.7014482432020082	[10]	[53]	6	hSpCas9	negative selection	12357436
48526134	48526157	15	+	28162770	OCIAML3	viability	GCATCTGGTACCATCTGGAGAGG	FBN1	ENSG00000166147	-0.009045139603007124	[24]	[74]	0	hSpCas9	negative selection	12357437
48516278	48516301	15	+	28162770	OCIAML3	viability	GGAGGAATGGGGCCAAGGGGTGG	FBN1	ENSG00000166147	-0.972519263577893	[38]	[59]	-6	hSpCas9	negative selection	12357438
48516260	48516283	15	+	28162770	OCIAML3	viability	GGAGGAACAGGGAGAACTGGAGG	FBN1	ENSG00000166147	-1.2668428970706538	[54]	[68]	-7	hSpCas9	negative selection	12357439
48503861	48503884	15	+	28162770	OCIAML3	viability	TTAGTGACAGCACCAAACAAAGG	FBN1	ENSG00000166147	-0.5008982359326816	[59]	[127]	-4	hSpCas9	negative selection	12357440