| 19138546 | 19138569 | 17 | + | 26472758 | Jiyoye | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | 0.9477437628685759 | [10] | [15] | 6 | hSpCas9 | negative selection | 67008 | 19138562 | 19138585 | 17 | - | 26472758 | Jiyoye | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | -0.025784025770232755 | [215] | [159] | 0 | hSpCas9 | negative selection | 67010 | 19138546 | 19138569 | 17 | + | 26472758 | Jiyoye | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | 0.9477437628685759 | [10] | [15] | 6 | hSpCas9 | negative selection | 67023 | 19127649 | 19127672 | 17 | + | 26472758 | Jiyoye | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | -2.0782514456643684 | [55] | [9] | -8 | hSpCas9 | negative selection | 67025 | 19138562 | 19138585 | 17 | - | 26472758 | Jiyoye | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | -0.025784025770232755 | [215] | [159] | 0 | hSpCas9 | negative selection | 67028 | 19127662 | 19127685 | 17 | + | 26472758 | Jiyoye | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | 0.27789236456090705 | [139] | [127] | 2 | hSpCas9 | negative selection | 67029 | 19138487 | 19138510 | 17 | - | 26472758 | Jiyoye | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -0.4360991148066735 | [60] | [33] | -3 | hSpCas9 | negative selection | 67032 | 19127610 | 19127633 | 17 | + | 26472758 | Jiyoye | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.49463822275621294 | [79] | [84] | 4 | hSpCas9 | negative selection | 67034 | 19127676 | 19127699 | 17 | + | 26472758 | Jiyoye | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | -0.2326490542498011 | [267] | [171] | -2 | hSpCas9 | negative selection | 67035 | 19132722 | 19132745 | 17 | - | 26472758 | Jiyoye | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.3982520919806163 | [186] | [106] | -3 | hSpCas9 | negative selection | 67038 | 19138523 | 19138546 | 17 | - | 26472758 | Jiyoye | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -0.09532495902330984 | [50] | [35] | 0 | hSpCas9 | negative selection | 67040 | 19127627 | 19127650 | 17 | - | 26472758 | Jiyoye | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | -0.4408215250490768 | [179] | [99] | -3 | hSpCas9 | negative selection | 67042 | 19138546 | 19138569 | 17 | + | 26472758 | KBM7 | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | 0.7093689215538144 | [111,89] | [92,62] | 7 | hSpCas9 | negative selection | 258126 | 19138562 | 19138585 | 17 | - | 26472758 | KBM7 | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | -0.4441457909953669 | [592,381] | [286,56] | -4 | hSpCas9 | negative selection | 258128 | 19138546 | 19138569 | 17 | + | 26472758 | KBM7 | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | 0.7093689215538144 | [111,89] | [92,62] | 7 | hSpCas9 | negative selection | 258141 | 19127649 | 19127672 | 17 | + | 26472758 | KBM7 | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | 0.005213872356389926 | [167,151] | [122,32] | 0 | hSpCas9 | negative selection | 258143 | 19138562 | 19138585 | 17 | - | 26472758 | KBM7 | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | -0.4441457909953669 | [592,381] | [286,56] | -4 | hSpCas9 | negative selection | 258146 | 19127662 | 19127685 | 17 | + | 26472758 | KBM7 | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -1.5262863760864178 | [892,812] | [143,134] | -8 | hSpCas9 | negative selection | 258147 | 19138487 | 19138510 | 17 | - | 26472758 | KBM7 | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -0.5375048600402677 | [138,73] | [12,51] | -5 | hSpCas9 | negative selection | 258150 | 19127610 | 19127633 | 17 | + | 26472758 | KBM7 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.4989716049256648 | [445,286] | [141,99] | -4 | hSpCas9 | negative selection | 258152 | 19127676 | 19127699 | 17 | + | 26472758 | KBM7 | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | 0.6739261409412765 | [1035,982] | [1156,402] | 7 | hSpCas9 | negative selection | 258153 | 19132722 | 19132745 | 17 | - | 26472758 | KBM7 | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | 0.1173729351919881 | [726,723] | [281,451] | 1 | hSpCas9 | negative selection | 258156 | 19138523 | 19138546 | 17 | - | 26472758 | KBM7 | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -1.0996535455426921 | [254,181] | [68,27] | -7 | hSpCas9 | negative selection | 258158 | 19127627 | 19127650 | 17 | - | 26472758 | KBM7 | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 0.16846972212149525 | [789,598] | [351,373] | 1 | hSpCas9 | negative selection | 258160 | 19138546 | 19138569 | 17 | + | 26472758 | Raji | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | -0.35204808326369763 | [54] | [9] | -3 | hSpCas9 | negative selection | 449244 | 19138562 | 19138585 | 17 | - | 26472758 | Raji | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | 0.24140088334528698 | [338] | [92] | 2 | hSpCas9 | negative selection | 449246 | 19138546 | 19138569 | 17 | + | 26472758 | Raji | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | -0.35204808326369763 | [54] | [9] | -3 | hSpCas9 | negative selection | 449259 | 19127649 | 19127672 | 17 | + | 26472758 | Raji | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | -0.2849338874051608 | [104] | [19] | -2 | hSpCas9 | negative selection | 449261 | 19138562 | 19138585 | 17 | - | 26472758 | Raji | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | 0.24140088334528698 | [338] | [92] | 2 | hSpCas9 | negative selection | 449264 | 19127662 | 19127685 | 17 | + | 26472758 | Raji | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -0.3700945386811513 | [361] | [64] | -3 | hSpCas9 | negative selection | 449265 | 19138487 | 19138510 | 17 | - | 26472758 | Raji | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | 1.6841721046490554 | [58] | [43] | 9 | hSpCas9 | negative selection | 449268 | 19127610 | 19127633 | 17 | + | 26472758 | Raji | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.38568469786070386 | [187] | [56] | 3 | hSpCas9 | negative selection | 449270 | 19127676 | 19127699 | 17 | + | 26472758 | Raji | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | 0.8045873006644331 | [411] | [166] | 7 | hSpCas9 | negative selection | 449271 | 19132722 | 19132745 | 17 | - | 26472758 | Raji | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.9257833285615998 | [351] | [42] | -6 | hSpCas9 | negative selection | 449274 | 19138523 | 19138546 | 17 | - | 26472758 | Raji | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -0.5865133369007207 | [219] | [33] | -5 | hSpCas9 | negative selection | 449276 | 19127627 | 19127650 | 17 | - | 26472758 | Raji | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | -0.4512676882317094 | [488] | [82] | -4 | hSpCas9 | negative selection | 449278 | 19138546 | 19138569 | 17 | + | 26472758 | K562 | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | -1.5795509082420534 | [130] | [36] | -7 | hSpCas9 | negative selection | 640362 | 19138562 | 19138585 | 17 | - | 26472758 | K562 | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | -1.247219185570743 | [418] | [148] | -6 | hSpCas9 | negative selection | 640364 | 19138546 | 19138569 | 17 | + | 26472758 | K562 | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | -1.5795509082420534 | [130] | [36] | -7 | hSpCas9 | negative selection | 640377 | 19127649 | 19127672 | 17 | + | 26472758 | K562 | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | 0.015794352618484275 | [115] | [98] | 0 | hSpCas9 | negative selection | 640379 | 19138562 | 19138585 | 17 | - | 26472758 | K562 | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | -1.247219185570743 | [418] | [148] | -6 | hSpCas9 | negative selection | 640382 | 19127662 | 19127685 | 17 | + | 26472758 | K562 | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -3.0939462570315888 | [970] | [95] | -8 | hSpCas9 | negative selection | 640383 | 19138487 | 19138510 | 17 | - | 26472758 | K562 | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -0.5733779411128037 | [103] | [58] | -4 | hSpCas9 | negative selection | 640386 | 19127610 | 19127633 | 17 | + | 26472758 | K562 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.3428428891442974 | [313] | [208] | -2 | hSpCas9 | negative selection | 640388 | 19127676 | 19127699 | 17 | + | 26472758 | K562 | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | -0.4332404482083913 | [698] | [436] | -3 | hSpCas9 | negative selection | 640389 | 19132722 | 19132745 | 17 | - | 26472758 | K562 | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | 0.15332566887347 | [571] | [536] | 1 | hSpCas9 | negative selection | 640392 | 19138523 | 19138546 | 17 | - | 26472758 | K562 | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -2.3820204090308685 | [246] | [39] | -8 | hSpCas9 | negative selection | 640394 | 19127627 | 19127650 | 17 | - | 26472758 | K562 | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 0.32012838749110856 | [463] | [488] | 2 | hSpCas9 | negative selection | 640396 | 19127627 | 19127650 | 17 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | -0.6063267886610623 | [3,2] | [2,0] | -7 | hSpCas9 | positive selection | 2991942 | 19132686 | 19132709 | 17 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | 0.03327553569374822 | [3,3] | [3,2] | 0 | hSpCas9 | positive selection | 2991943 | 19132686 | 19132709 | 17 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | 0.03327553569374822 | [3,3] | [3,2] | 0 | hSpCas9 | positive selection | 2991944 | 19132686 | 19132709 | 17 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | 0.03327553569374822 | [3,3] | [3,2] | 0 | hSpCas9 | positive selection | 2991945 | 19132686 | 19132709 | 17 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | 0.03327553569374822 | [3,3] | [3,2] | 0 | hSpCas9 | positive selection | 2991946 | 19132657 | 19132680 | 17 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GGATGACCAGAACTGGTACAAGG | GRAPL | ENSG00000189152 | 0.1046091021234106 | [3,3] | [3,2] | 2 | hSpCas9 | positive selection | 2991947 | 19127633 | 19127656 | 17 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | -0.1184551934200038 | [3,3] | [4,1] | -2 | hSpCas9 | positive selection | 2991948 | 19127633 | 19127656 | 17 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | -0.1184551934200038 | [3,3] | [4,1] | -2 | hSpCas9 | positive selection | 2991949 | 19127633 | 19127656 | 17 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | -0.1184551934200038 | [3,3] | [4,1] | -2 | hSpCas9 | positive selection | 2991950 | 19127633 | 19127656 | 17 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | -0.1184551934200038 | [3,3] | [4,1] | -2 | hSpCas9 | positive selection | 2991951 | 19127627 | 19127650 | 17 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | -0.6184245025781111 | [3,3] | [2,0] | -8 | hSpCas9 | positive selection | 3059800 | 19132686 | 19132709 | 17 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | 0.15539353375700937 | [3,3] | [2,3] | 2 | hSpCas9 | positive selection | 3059801 | 19132686 | 19132709 | 17 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | 0.15539353375700937 | [3,3] | [2,3] | 2 | hSpCas9 | positive selection | 3059802 | 19132686 | 19132709 | 17 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | 0.15539353375700937 | [3,3] | [2,3] | 2 | hSpCas9 | positive selection | 3059803 | 19132686 | 19132709 | 17 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | 0.15539353375700937 | [3,3] | [2,3] | 2 | hSpCas9 | positive selection | 3059804 | 19132657 | 19132680 | 17 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GGATGACCAGAACTGGTACAAGG | GRAPL | ENSG00000189152 | 0.6478247517803847 | [3,3] | [3,3] | 9 | hSpCas9 | positive selection | 3059805 | 19127633 | 19127656 | 17 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 0.35713065001229405 | [3,3] | [3,3] | 6 | hSpCas9 | positive selection | 3059806 | 19127633 | 19127656 | 17 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 0.35713065001229405 | [3,3] | [3,3] | 6 | hSpCas9 | positive selection | 3059807 | 19127633 | 19127656 | 17 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 0.35713065001229405 | [3,3] | [3,3] | 6 | hSpCas9 | positive selection | 3059808 | 19127633 | 19127656 | 17 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 0.35713065001229405 | [3,3] | [3,3] | 6 | hSpCas9 | positive selection | 3059809 | 19138563 | 19138586 | 17 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | ACAGACACAGAGAACTCCCCTGG | GRAPL | ENSG00000189152 | -0.3425866307412928 | [193,193] | [0,0] | -2 | hSpCas9 | positive selection | 3371642 | 19138455 | 19138478 | 17 | + | 27383988 | 293T | resistance to West Nile virus (flavivirus) | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -6.163124681677816e-05 | [152,152] | [0,0] | 0 | hSpCas9 | positive selection | 3371643 | 19127627 | 19127650 | 17 | - | 26780180 | HT29 | viability (Avana library 4 designs) | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 2.75514429535769 | [] | [] | 8 | hSpCas9 | negative selection | 3429148 | 19132686 | 19132709 | 17 | - | 26780180 | HT29 | viability (Avana library 4 designs) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | 1.87976024914456 | [] | [] | 7 | hSpCas9 | negative selection | 3429149 | 19132686 | 19132709 | 17 | - | 26780180 | HT29 | viability (Avana library 4 designs) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | 1.87976024914456 | [] | [] | 7 | hSpCas9 | negative selection | 3429150 | 19132656 | 19132679 | 17 | + | 26780180 | HT29 | viability (Avana library 4 designs) | GGATGACCAGAACTGGTACAAGG | GRAPL | ENSG00000189152 | 1.56506997820024 | [] | [] | 6 | hSpCas9 | negative selection | 3429151 | 19127633 | 19127656 | 17 | - | 26780180 | HT29 | viability (Avana library 4 designs) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 1.1384076941626 | [] | [] | 4 | hSpCas9 | negative selection | 3429152 | 19127633 | 19127656 | 17 | - | 26780180 | HT29 | viability (Avana library 4 designs) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 1.1384076941626 | [] | [] | 4 | hSpCas9 | negative selection | 3429153 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 4.12488697537122 | [] | [] | 6 | hSpCas9 | negative selection | 3513675 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 4.12488697537122 | [] | [] | 6 | hSpCas9 | negative selection | 3513676 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 3.41881026419151 | [] | [] | 5 | hSpCas9 | negative selection | 3513677 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 3.41881026419151 | [] | [] | 5 | hSpCas9 | negative selection | 3513678 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | -9.24386009241212 | [] | [] | -7 | hSpCas9 | negative selection | 3513679 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | -9.24386009241212 | [] | [] | -7 | hSpCas9 | negative selection | 3513680 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | -9.35555722670638 | [] | [] | -7 | hSpCas9 | negative selection | 3513681 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | -9.35555722670638 | [] | [] | -7 | hSpCas9 | negative selection | 3513682 | 19132656 | 19132679 | 17 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GGATGACCAGAACTGGTACAAGG | GRAPL | ENSG00000189152 | 0.219441998384492 | [] | [] | 0 | hSpCas9 | negative selection | 3513683 | 19127627 | 19127650 | 17 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 2.18873493706828 | [] | [] | 3 | hSpCas9 | negative selection | 3513684 | 19127662 | 19127685 | 17 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | 0.608900565363072 | [] | [] | 0 | hSpCas9 | negative selection | 3513685 | 19132722 | 19132745 | 17 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -3.48402335158243 | [] | [] | -4 | hSpCas9 | negative selection | 3513686 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | viability (Avana lentiGuide) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | -0.173992075891732 | [] | [] | 0 | hSpCas9 | negative selection | 3622334 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | viability (Avana lentiGuide) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | -0.173992075891732 | [] | [] | 0 | hSpCas9 | negative selection | 3622335 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | viability (Avana lentiGuide) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 0.344431930880929 | [] | [] | 0 | hSpCas9 | negative selection | 3622336 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | viability (Avana lentiGuide) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 0.344431930880929 | [] | [] | 0 | hSpCas9 | negative selection | 3622337 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | viability (Avana lentiGuide) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | 0.826967596928784 | [] | [] | 1 | hSpCas9 | negative selection | 3622338 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | viability (Avana lentiGuide) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | 0.826967596928784 | [] | [] | 1 | hSpCas9 | negative selection | 3622339 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | viability (Avana lentiGuide) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | 7.71815899785993 | [] | [] | 6 | hSpCas9 | negative selection | 3622340 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | viability (Avana lentiGuide) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | 7.71815899785993 | [] | [] | 6 | hSpCas9 | negative selection | 3622341 | 19132656 | 19132679 | 17 | + | 26780180 | A375 | viability (Avana lentiGuide) | GGATGACCAGAACTGGTACAAGG | GRAPL | ENSG00000189152 | 5.73555916242136 | [] | [] | 5 | hSpCas9 | negative selection | 3622342 | 19127627 | 19127650 | 17 | - | 26780180 | A375 | viability (Avana lentiGuide) | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 4.15646262594518 | [] | [] | 4 | hSpCas9 | negative selection | 3622343 | 19127662 | 19127685 | 17 | + | 26780180 | A375 | viability (Avana lentiGuide) | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | 21.968516247967 | [] | [] | 9 | hSpCas9 | negative selection | 3622344 | 19132722 | 19132745 | 17 | - | 26780180 | A375 | viability (Avana lentiGuide) | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | 15.9831273719765 | [] | [] | 8 | hSpCas9 | negative selection | 3622345 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 0.11847958132676219 | [5] | [5,5] | 3 | hSpCas9 | positive selection | 3730993 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 0.11847958132676219 | [5] | [5,5] | 3 | hSpCas9 | positive selection | 3730994 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | -0.5869079651841995 | [5] | [3,3] | -7 | hSpCas9 | positive selection | 3730995 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | -0.5869079651841995 | [4] | [3,1] | -7 | hSpCas9 | positive selection | 3730996 | 19132656 | 19132679 | 17 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GGATGACCAGAACTGGTACAAGG | GRAPL | ENSG00000189152 | 0.02953062401301934 | [4] | [5,3] | 0 | hSpCas9 | positive selection | 3730997 | 19127627 | 19127650 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 0.13089150723279644 | [5] | [5,5] | 3 | hSpCas9 | positive selection | 3730998 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | -0.37669568754703675 | [5] | [3,3] | -5 | hSpCas9 | positive selection | 3730999 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | -0.37669568754703675 | [4] | [3,1] | -5 | hSpCas9 | positive selection | 3731000 | 19127662 | 19127685 | 17 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -0.37669568754703675 | [3] | [3,3] | -5 | hSpCas9 | positive selection | 3731001 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | -0.0075812592183662104 | [5] | [5,5] | 0 | hSpCas9 | positive selection | 3731002 | 19132722 | 19132745 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.0075812592183662104 | [4] | [2,3] | 0 | hSpCas9 | positive selection | 3731003 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | -0.0075812592183662104 | [5] | [5,5] | 0 | hSpCas9 | positive selection | 3731004 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 0.13207024935429504 | [5] | [4,4] | 3 | hSpCas9 | positive selection | 3839600 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | 0.13207024935429504 | [5] | [5,4] | 3 | hSpCas9 | positive selection | 3839601 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | -0.11934447123838443 | [5] | [6,4] | -2 | hSpCas9 | positive selection | 3839602 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | -0.11934447123838443 | [5] | [3,3] | -2 | hSpCas9 | positive selection | 3839603 | 19132656 | 19132679 | 17 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GGATGACCAGAACTGGTACAAGG | GRAPL | ENSG00000189152 | -0.05550177930647725 | [5] | [4,3] | -1 | hSpCas9 | positive selection | 3839604 | 19127627 | 19127650 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | -0.011814260826141973 | [5] | [4,4] | 0 | hSpCas9 | positive selection | 3839605 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | -0.39676317756377816 | [5] | [6,4] | -5 | hSpCas9 | positive selection | 3839606 | 19132686 | 19132709 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GAATAAATCCCTCGACACCCCGG | GRAPL | ENSG00000189152 | -0.39676317756377816 | [5] | [3,3] | -5 | hSpCas9 | positive selection | 3839607 | 19127662 | 19127685 | 17 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -0.39676317756377816 | [4] | [0,0] | -5 | hSpCas9 | positive selection | 3839608 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | -0.010355302364407154 | [5] | [4,4] | 0 | hSpCas9 | positive selection | 3839609 | 19132722 | 19132745 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.010355302364407154 | [5] | [4,1] | 0 | hSpCas9 | positive selection | 3839610 | 19127633 | 19127656 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TGTAGCCTGAAAGCTGTACAGGG | GRAPL | ENSG00000189152 | -0.010355302364407154 | [5] | [5,4] | 0 | hSpCas9 | positive selection | 3839611 | 19138455 | 19138478 | 17 | + | 26780180 | A375 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | 1.83728753929305 | [] | [] | 9 | hSpCas9 | negative selection | 3945761 | 19138455 | 19138478 | 17 | + | 26780180 | HT29 | viability (GeCKOv2 library) | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | 1.98343696455914 | [] | [] | 9 | hSpCas9 | negative selection | 4053727 | 19127610 | 19127633 | 17 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.14256827103509995 | [2] | [2,1] | 3 | hSpCas9 | positive selection | 4273903 | 19132632 | 19132655 | 17 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.018908803006408348 | [4] | [3,2] | 0 | hSpCas9 | positive selection | 4338156 | 19138455 | 19138478 | 17 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.27070132128513114 | [3] | [1,1] | -5 | hSpCas9 | positive selection | 4338163 | 19132669 | 19132691 | 17 | + | 27760321 | OCIAML3 | viability | TGGTACAAGGCCGAGCTCCGGG | GRAPL | ENSG00000189152 | 0.7617415988395106 | [679,629] | [869,866] | 8 | hSpCas9 | negative selection | 4405269 | 19132722 | 19132744 | 17 | - | 27760321 | OCIAML3 | viability | TCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.3167209250558791 | [1354,1135] | [676,911] | -3 | hSpCas9 | negative selection | 4405270 | 19138455 | 19138477 | 17 | + | 27760321 | OCIAML3 | viability | TCTCTCCGCAGGTGGTACTCGG | GRAPL | ENSG00000189152 | 0.01980791732919232 | [531,506] | [421,399] | 0 | hSpCas9 | negative selection | 4405271 | 19138487 | 19138509 | 17 | - | 27760321 | OCIAML3 | viability | AATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | 0.15917034396168472 | [1150,1041] | [790,1172] | 1 | hSpCas9 | negative selection | 4405272 | 19132669 | 19132691 | 17 | + | 27760321 | OCIAML2 | viability | TGGTACAAGGCCGAGCTCCGGG | GRAPL | ENSG00000189152 | -0.14207549941266334 | [679,629] | [443,527] | -2 | hSpCas9 | negative selection | 4488732 | 19132722 | 19132744 | 17 | - | 27760321 | OCIAML2 | viability | TCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.6440367689280478 | [1354,1135] | [567,739] | -6 | hSpCas9 | negative selection | 4488733 | 19138455 | 19138477 | 17 | + | 27760321 | OCIAML2 | viability | TCTCTCCGCAGGTGGTACTCGG | GRAPL | ENSG00000189152 | -0.6262081267087207 | [531,506] | [263,283] | -6 | hSpCas9 | negative selection | 4488734 | 19138487 | 19138509 | 17 | - | 27760321 | OCIAML2 | viability | AATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | 0.09783943287810204 | [1150,1041] | [935,964] | 1 | hSpCas9 | negative selection | 4488735 | 19132669 | 19132691 | 17 | + | 27760321 | MV411 | viability | TGGTACAAGGCCGAGCTCCGGG | GRAPL | ENSG00000189152 | 0.8365946765163692 | [679,629] | [1030,382] | 6 | hSpCas9 | negative selection | 4572195 | 19132722 | 19132744 | 17 | - | 27760321 | MV411 | viability | TCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | 0.14055120819763234 | [1354,1135] | [716,1180] | 1 | hSpCas9 | negative selection | 4572196 | 19138455 | 19138477 | 17 | + | 27760321 | MV411 | viability | TCTCTCCGCAGGTGGTACTCGG | GRAPL | ENSG00000189152 | -0.2433618523840356 | [531,506] | [269,319] | -2 | hSpCas9 | negative selection | 4572197 | 19138487 | 19138509 | 17 | - | 27760321 | MV411 | viability | AATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | 0.5513401877504227 | [1150,1041] | [728,1555] | 4 | hSpCas9 | negative selection | 4572198 | 19132669 | 19132691 | 17 | + | 27760321 | HL60 | viability | TGGTACAAGGCCGAGCTCCGGG | GRAPL | ENSG00000189152 | 0.08802573023957727 | [679,629] | [611,522] | 1 | hSpCas9 | negative selection | 4655658 | 19132722 | 19132744 | 17 | - | 27760321 | HL60 | viability | TCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | 0.1396840374834405 | [1354,1135] | [948,1293] | 1 | hSpCas9 | negative selection | 4655659 | 19138455 | 19138477 | 17 | + | 27760321 | HL60 | viability | TCTCTCCGCAGGTGGTACTCGG | GRAPL | ENSG00000189152 | -0.0317075831995611 | [531,506] | [338,496] | 0 | hSpCas9 | negative selection | 4655660 | 19138487 | 19138509 | 17 | - | 27760321 | HL60 | viability | AATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | 0.04803996644367792 | [1150,1041] | [785,1072] | 0 | hSpCas9 | negative selection | 4655661 | 19132669 | 19132691 | 17 | + | 27760321 | HT1080 | viability | TGGTACAAGGCCGAGCTCCGGG | GRAPL | ENSG00000189152 | -0.25505245390453485 | [629,491] | [150,226] | -1 | hSpCas9 | negative selection | 4739121 | 19132722 | 19132744 | 17 | - | 27760321 | HT1080 | viability | TCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.04473883627240083 | [1135,886] | [393,386] | 0 | hSpCas9 | negative selection | 4739122 | 19138455 | 19138477 | 17 | + | 27760321 | HT1080 | viability | TCTCTCCGCAGGTGGTACTCGG | GRAPL | ENSG00000189152 | -0.18918637511200997 | [506,395] | [57,266] | -1 | hSpCas9 | negative selection | 4739123 | 19138487 | 19138509 | 17 | - | 27760321 | HT1080 | viability | AATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | 0.2173242864385445 | [1041,812] | [535,312] | 1 | hSpCas9 | negative selection | 4739124 | 19132669 | 19132691 | 17 | + | 27760321 | HT29 | viability after 7 days | TGGTACAAGGCCGAGCTCCGGG | GRAPL | ENSG00000189152 | -0.2807763511246126 | [629,491] | [687,644,464] | -4 | hSpCas9 | negative selection | 4822584 | 19132722 | 19132744 | 17 | - | 27760321 | HT29 | viability after 7 days | TCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | 0.05731511255191579 | [1135,886] | [1445,1303,1321] | 0 | hSpCas9 | negative selection | 4822585 | 19138455 | 19138477 | 17 | + | 27760321 | HT29 | viability after 7 days | TCTCTCCGCAGGTGGTACTCGG | GRAPL | ENSG00000189152 | -0.2449918985990293 | [506,395] | [611,279,590] | -4 | hSpCas9 | negative selection | 4822586 | 19138487 | 19138509 | 17 | - | 27760321 | HT29 | viability after 7 days | AATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -0.3865807577492262 | [1041,812] | [1030,740,977] | -5 | hSpCas9 | negative selection | 4822587 | 19132669 | 19132691 | 17 | + | 27760321 | HT29 | viability after 25 days | TGGTACAAGGCCGAGCTCCGGG | GRAPL | ENSG00000189152 | -0.26071633637235747 | [629,491] | [654,648,264] | -3 | hSpCas9 | negative selection | 4906047 | 19132722 | 19132744 | 17 | - | 27760321 | HT29 | viability after 25 days | TCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.3679979443178867 | [1135,886] | [744,1091,853] | -4 | hSpCas9 | negative selection | 4906048 | 19138455 | 19138477 | 17 | + | 27760321 | HT29 | viability after 25 days | TCTCTCCGCAGGTGGTACTCGG | GRAPL | ENSG00000189152 | -0.5973145166141879 | [506,395] | [294,411,315] | -5 | hSpCas9 | negative selection | 4906049 | 19138487 | 19138509 | 17 | - | 27760321 | HT29 | viability after 25 days | AATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -0.6746451808029224 | [1041,812] | [590,565,858] | -5 | hSpCas9 | negative selection | 4906050 | 19132669 | 19132691 | 17 | + | 27760321 | HT29 | viability after 22 days | TGGTACAAGGCCGAGCTCCGGG | GRAPL | ENSG00000189152 | -0.32668149738682384 | [629,491] | [657,436,451] | -3 | hSpCas9 | negative selection | 4989510 | 19132722 | 19132744 | 17 | - | 27760321 | HT29 | viability after 22 days | TCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.07182928632915941 | [1135,886] | [1097,1345,891] | 0 | hSpCas9 | negative selection | 4989511 | 19138455 | 19138477 | 17 | + | 27760321 | HT29 | viability after 22 days | TCTCTCCGCAGGTGGTACTCGG | GRAPL | ENSG00000189152 | -0.6171499568266272 | [506,395] | [318,308,393] | -5 | hSpCas9 | negative selection | 4989512 | 19138487 | 19138509 | 17 | - | 27760321 | HT29 | viability after 22 days | AATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -0.8680896749189877 | [1041,812] | [444,538,783] | -6 | hSpCas9 | negative selection | 4989513 | 19132669 | 19132691 | 17 | + | 27760321 | HT29 | viability after 19 days | TGGTACAAGGCCGAGCTCCGGG | GRAPL | ENSG00000189152 | -0.3427350049444189 | [629,491] | [546,741,242] | -3 | hSpCas9 | negative selection | 5072973 | 19132722 | 19132744 | 17 | - | 27760321 | HT29 | viability after 19 days | TCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.3406669776306688 | [1135,886] | [759,1051,911] | -3 | hSpCas9 | negative selection | 5072974 | 19138455 | 19138477 | 17 | + | 27760321 | HT29 | viability after 19 days | TCTCTCCGCAGGTGGTACTCGG | GRAPL | ENSG00000189152 | -0.805989578069215 | [506,395] | [431,274,196] | -6 | hSpCas9 | negative selection | 5072975 | 19138487 | 19138509 | 17 | - | 27760321 | HT29 | viability after 19 days | AATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -1.016643862188658 | [1041,812] | [558,515,501] | -6 | hSpCas9 | negative selection | 5072976 | 19132669 | 19132691 | 17 | + | 27760321 | HT29 | viability after 16 days | TGGTACAAGGCCGAGCTCCGGG | GRAPL | ENSG00000189152 | -0.6866674678590451 | [629,491] | [523,408,248] | -6 | hSpCas9 | negative selection | 5156436 | 19132722 | 19132744 | 17 | - | 27760321 | HT29 | viability after 16 days | TCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.42259673913757645 | [1135,886] | [1003,689,857] | -4 | hSpCas9 | negative selection | 5156437 | 19138455 | 19138477 | 17 | + | 27760321 | HT29 | viability after 16 days | TCTCTCCGCAGGTGGTACTCGG | GRAPL | ENSG00000189152 | -0.3114189931449056 | [506,395] | [534,455,240] | -3 | hSpCas9 | negative selection | 5156438 | 19138487 | 19138509 | 17 | - | 27760321 | HT29 | viability after 16 days | AATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -1.0613470118784938 | [1041,812] | [700,415,395] | -7 | hSpCas9 | negative selection | 5156439 | 19132669 | 19132691 | 17 | + | 27760321 | HT29 | viability after 13 days | TGGTACAAGGCCGAGCTCCGGG | GRAPL | ENSG00000189152 | -0.5370489086217829 | [629,491] | [325,624,397] | -6 | hSpCas9 | negative selection | 5239899 | 19132722 | 19132744 | 17 | - | 27760321 | HT29 | viability after 13 days | TCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.5929391203619476 | [1135,886] | [565,949,815] | -6 | hSpCas9 | negative selection | 5239900 | 19138455 | 19138477 | 17 | + | 27760321 | HT29 | viability after 13 days | TCTCTCCGCAGGTGGTACTCGG | GRAPL | ENSG00000189152 | -0.34256830627380697 | [506,395] | [510,246,476] | -4 | hSpCas9 | negative selection | 5239901 | 19138487 | 19138509 | 17 | - | 27760321 | HT29 | viability after 13 days | AATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -0.7266091979162043 | [1041,812] | [458,789,698] | -6 | hSpCas9 | negative selection | 5239902 | 19132669 | 19132691 | 17 | + | 27760321 | HT29 | viability after 10 days | TGGTACAAGGCCGAGCTCCGGG | GRAPL | ENSG00000189152 | -0.448754545759235 | [629,491] | [325,685,531] | -5 | hSpCas9 | negative selection | 5323362 | 19132722 | 19132744 | 17 | - | 27760321 | HT29 | viability after 10 days | TCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.27240844510926987 | [1135,886] | [1265,911,956] | -3 | hSpCas9 | negative selection | 5323363 | 19138455 | 19138477 | 17 | + | 27760321 | HT29 | viability after 10 days | TCTCTCCGCAGGTGGTACTCGG | GRAPL | ENSG00000189152 | 0.08735995174438405 | [506,395] | [712,352,720] | 1 | hSpCas9 | negative selection | 5323364 | 19138487 | 19138509 | 17 | - | 27760321 | HT29 | viability after 10 days | AATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -0.17270532336010214 | [1041,812] | [994,1303,795] | -2 | hSpCas9 | negative selection | 5323365 | 19132669 | 19132691 | 17 | + | 27760321 | MOLM13 | viability | TGGTACAAGGCCGAGCTCCGGG | GRAPL | ENSG00000189152 | 0.4769911088197427 | [679,629] | [622,421] | 3 | hSpCas9 | negative selection | 5406825 | 19132722 | 19132744 | 17 | - | 27760321 | MOLM13 | viability | TCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | 0.5167623049470993 | [1354,1135] | [349,1555] | 3 | hSpCas9 | negative selection | 5406826 | 19138455 | 19138477 | 17 | + | 27760321 | MOLM13 | viability | TCTCTCCGCAGGTGGTACTCGG | GRAPL | ENSG00000189152 | -0.7986883929034807 | [531,506] | [185,153] | -5 | hSpCas9 | negative selection | 5406827 | 19138487 | 19138509 | 17 | - | 27760321 | MOLM13 | viability | AATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -0.17776529454319578 | [1150,1041] | [660,448] | -1 | hSpCas9 | negative selection | 5406828 | 19127596 | 19127619 | 17 | + | 27661255 | K562 | viability | GCTGCTGGAGCCCCGAGCAGCGG | GRAPL | ENSG00000189152 | 0.0969794087443335 | [843,822] | [814,624] | 3 | dCas9-KRAB | negative selection | 5483289 | 19127610 | 19127633 | 17 | + | 27661255 | K562 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.2285327355375999 | [1236,1339] | [1255,1159] | 7 | dCas9-KRAB | negative selection | 5483292 | 19127684 | 19127707 | 17 | + | 27661255 | K562 | viability | GAGACACACTCAAGGTAGGGGGG | GRAPL | ENSG00000189152 | 0.2834853941159202 | [1227,1428] | [1421,1173] | 8 | dCas9-KRAB | negative selection | 5483293 | 19127767 | 19127790 | 17 | + | 27661255 | K562 | viability | GGACTGTCCCAAGCAGACTGTGG | GRAPL | ENSG00000189152 | -0.4456337786382045 | [252,219] | [144,133] | -7 | dCas9-KRAB | negative selection | 5483295 | 19127606 | 19127629 | 17 | - | 27661255 | K562 | viability | GGACTCCATGCCGCTGCTCGGGG | GRAPL | ENSG00000189152 | -0.022971923124656568 | [1136,1430] | [987,1019] | -1 | dCas9-KRAB | negative selection | 5483297 | 19127610 | 19127633 | 17 | + | 27260156 | BXPC3 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.1792010273514295 | [261] | [237,210,285,232] | -4 | hSpCas9 | negative selection | 5546363 | 19132632 | 19132655 | 17 | + | 27260156 | BXPC3 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.2003602844957708 | [1192] | [984,976,1137,1276] | -4 | hSpCas9 | negative selection | 5610616 | 19138455 | 19138478 | 17 | + | 27260156 | BXPC3 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.5714414782553694 | [546] | [371,292,459,424] | -8 | hSpCas9 | negative selection | 5610623 | 19127610 | 19127633 | 17 | + | 27260156 | A673 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.03379350248117985 | [261] | [261,233,501,280] | 0 | hSpCas9 | negative selection | 5667614 | 19132632 | 19132655 | 17 | + | 27260156 | A673 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.16463835115872572 | [1192] | [1394,993,1324,1423] | -4 | hSpCas9 | negative selection | 5731867 | 19138455 | 19138478 | 17 | + | 27260156 | A673 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.2018137460987665 | [546] | [543,574,482,684] | -5 | hSpCas9 | negative selection | 5731874 | 19127610 | 19127633 | 17 | + | 27260156 | A375 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.5145122307084788 | [261] | [209,207,313,132] | -6 | hSpCas9 | negative selection | 5788865 | 19132632 | 19132655 | 17 | + | 27260156 | A375 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.5085117262431506 | [1192] | [847,1074,954,1040] | -6 | hSpCas9 | negative selection | 5853118 | 19138455 | 19138478 | 17 | + | 27260156 | A375 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.5291898007294688 | [546] | [458,645,318,380] | -6 | hSpCas9 | negative selection | 5853125 | 19127610 | 19127633 | 17 | + | 27260156 | COLO741 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.030655722410988906 | [261] | [369,344,274] | 0 | hSpCas9 | negative selection | 5910116 | 19132632 | 19132655 | 17 | + | 27260156 | COLO741 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.08660763570396357 | [1192] | [1815,1337,1198] | -2 | hSpCas9 | negative selection | 5974369 | 19138455 | 19138478 | 17 | + | 27260156 | COLO741 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.7270541266778171 | [546] | [394,494,376] | -9 | hSpCas9 | negative selection | 5974376 | 19127610 | 19127633 | 17 | + | 27260156 | CAL120 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.19015241700846763 | [261] | [286,390,423] | 3 | hSpCas9 | negative selection | 6031367 | 19132632 | 19132655 | 17 | + | 27260156 | CAL120 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.3289947787843528 | [1192] | [1647,831,1135] | -5 | hSpCas9 | negative selection | 6095620 | 19138455 | 19138478 | 17 | + | 27260156 | CAL120 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.4252561781643509 | [546] | [797,409,358] | -6 | hSpCas9 | negative selection | 6095627 | 19127610 | 19127633 | 17 | + | 27260156 | CADOES1 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.3430591922228352 | [261] | [231,268,462,270] | 6 | hSpCas9 | negative selection | 6152618 | 19132632 | 19132655 | 17 | + | 27260156 | CADOES1 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | 0.02464283641166043 | [1192] | [1215,1020,1052,1227] | 0 | hSpCas9 | negative selection | 6216871 | 19138455 | 19138478 | 17 | + | 27260156 | CADOES1 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.40687742200271104 | [546] | [364,369,387,412] | -6 | hSpCas9 | negative selection | 6216878 | 19127610 | 19127633 | 17 | + | 27260156 | EWS502 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.28255650006349975 | [261] | [273,247,430,413] | 5 | hSpCas9 | negative selection | 6273869 | 19132632 | 19132655 | 17 | + | 27260156 | EWS502 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.14155909323961957 | [1192] | [1085,1123,1003,1386] | -3 | hSpCas9 | negative selection | 6338122 | 19138455 | 19138478 | 17 | + | 27260156 | EWS502 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.3361684063318697 | [546] | [357,545,527,407] | -5 | hSpCas9 | negative selection | 6338129 | 19127610 | 19127633 | 17 | + | 27260156 | EW8 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.44253007288205415 | [261] | [217,332,214,391] | 7 | hSpCas9 | negative selection | 6395120 | 19132632 | 19132655 | 17 | + | 27260156 | EW8 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.06356404296805063 | [1192] | [1073,829,840,982] | -1 | hSpCas9 | negative selection | 6459373 | 19138455 | 19138478 | 17 | + | 27260156 | EW8 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.21073069541843967 | [546] | [530,429,221,391] | -4 | hSpCas9 | negative selection | 6459380 | 19127610 | 19127633 | 17 | + | 27260156 | CORL105 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.016597359553174207 | [261] | [329,295,378,220] | 0 | hSpCas9 | negative selection | 6516371 | 19132632 | 19132655 | 17 | + | 27260156 | CORL105 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.11767623617409062 | [1192] | [1257,1483,1422,1000] | -2 | hSpCas9 | negative selection | 6580624 | 19138455 | 19138478 | 17 | + | 27260156 | CORL105 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.6483695729437426 | [546] | [434,394,362,434] | -8 | hSpCas9 | negative selection | 6580631 | 19127610 | 19127633 | 17 | + | 27260156 | HS294T | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.0979241934075823 | [261] | [91,64,97,195] | 1 | hSpCas9 | negative selection | 6637622 | 19132632 | 19132655 | 17 | + | 27260156 | HS294T | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.26549184526529834 | [1192] | [356,252,445,504] | -4 | hSpCas9 | negative selection | 6701875 | 19138455 | 19138478 | 17 | + | 27260156 | HS294T | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.5190897081525361 | [546] | [114,101,152,239] | -6 | hSpCas9 | negative selection | 6701882 | 19127610 | 19127633 | 17 | + | 27260156 | HCC44 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.13625474508286217 | [261] | [185,149,376,598] | 2 | hSpCas9 | negative selection | 6758873 | 19132632 | 19132655 | 17 | + | 27260156 | HCC44 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.36823590911900006 | [1192] | [1067,1014,1040,1053] | -5 | hSpCas9 | negative selection | 6823126 | 19138455 | 19138478 | 17 | + | 27260156 | HCC44 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -1.0623602406093788 | [546] | [340,230,371,265] | -8 | hSpCas9 | negative selection | 6823133 | 19127610 | 19127633 | 17 | + | 27260156 | G402 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.06737088283987902 | [261] | [255,413,317,233] | -1 | hSpCas9 | negative selection | 6880124 | 19132632 | 19132655 | 17 | + | 27260156 | G402 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.1228397873398559 | [1192] | [1029,1950,1021,1330] | -1 | hSpCas9 | negative selection | 6944377 | 19138455 | 19138478 | 17 | + | 27260156 | G402 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.8403594480149945 | [546] | [411,462,346,282] | -7 | hSpCas9 | negative selection | 6944384 | 19127610 | 19127633 | 17 | + | 27260156 | L33 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.090677543817962 | [261] | [339,87,148,321] | 2 | hSpCas9 | negative selection | 7001375 | 19132632 | 19132655 | 17 | + | 27260156 | L33 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | 0.04754413075644526 | [1192] | [1157,581,901,923] | 1 | hSpCas9 | negative selection | 7065628 | 19138455 | 19138478 | 17 | + | 27260156 | L33 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.7502567614434232 | [546] | [328,108,174,425] | -9 | hSpCas9 | negative selection | 7065635 | 19127610 | 19127633 | 17 | + | 27260156 | K562 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.6229592977614493 | [261] | [261,129,65,152] | -6 | hSpCas9 | negative selection | 7122626 | 19132632 | 19132655 | 17 | + | 27260156 | K562 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.5072152607064816 | [1192] | [626,989,951,445] | -6 | hSpCas9 | negative selection | 7186879 | 19138455 | 19138478 | 17 | + | 27260156 | K562 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -1.0941022553219435 | [546] | [278,104,432,103] | -8 | hSpCas9 | negative selection | 7186886 | 19127610 | 19127633 | 17 | + | 27260156 | HT29 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.13512996669384947 | [261] | [369,317,237,245] | -3 | hSpCas9 | negative selection | 7243877 | 19132632 | 19132655 | 17 | + | 27260156 | HT29 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.26785502760488034 | [1192] | [1372,1304,1174,1002] | -5 | hSpCas9 | negative selection | 7308130 | 19138455 | 19138478 | 17 | + | 27260156 | HT29 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.7726611044448045 | [546] | [454,403,353,351] | -8 | hSpCas9 | negative selection | 7308137 | 19127610 | 19127633 | 17 | + | 27260156 | MHHES1 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.30970971921377566 | [261] | [371,300,258,486] | 5 | hSpCas9 | negative selection | 7365128 | 19132632 | 19132655 | 17 | + | 27260156 | MHHES1 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.13834480570617402 | [1192] | [1391,1798,1001,831] | -3 | hSpCas9 | negative selection | 7429381 | 19138455 | 19138478 | 17 | + | 27260156 | MHHES1 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.18845461462914234 | [546] | [258,784,678,441] | -4 | hSpCas9 | negative selection | 7429388 | 19127610 | 19127633 | 17 | + | 27260156 | MEWO | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.05872391912569075 | [261] | [245,263,253] | 1 | hSpCas9 | negative selection | 7486379 | 19132632 | 19132655 | 17 | + | 27260156 | MEWO | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.061993472476333356 | [1192] | [1312,769,1172] | -1 | hSpCas9 | negative selection | 7550632 | 19138455 | 19138478 | 17 | + | 27260156 | MEWO | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.21640018002601674 | [546] | [552,463,325] | -5 | hSpCas9 | negative selection | 7550639 | 19127610 | 19127633 | 17 | + | 27260156 | LNCAPCLONEFGC | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.034862567803639055 | [261] | [232,259,212,260] | 0 | hSpCas9 | negative selection | 7607630 | 19132632 | 19132655 | 17 | + | 27260156 | LNCAPCLONEFGC | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.3433334742670475 | [1192] | [705,875,1094,766] | -5 | hSpCas9 | negative selection | 7671883 | 19138455 | 19138478 | 17 | + | 27260156 | LNCAPCLONEFGC | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.44079100013258343 | [546] | [413,278,420,358] | -6 | hSpCas9 | negative selection | 7671890 | 19127610 | 19127633 | 17 | + | 27260156 | PANC0327 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -1.0506456501516905 | [261] | [55,85,65,239] | -8 | hSpCas9 | negative selection | 7728881 | 19132632 | 19132655 | 17 | + | 27260156 | PANC0327 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.21819991980535258 | [1192] | [889,689,757,1331] | -3 | hSpCas9 | negative selection | 7793134 | 19138455 | 19138478 | 17 | + | 27260156 | PANC0327 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.143741225500558 | [546] | [551,315,300,614] | -2 | hSpCas9 | negative selection | 7793141 | 19127610 | 19127633 | 17 | + | 27260156 | NCIH2009 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.03800291461435912 | [261] | [513,418,165] | 0 | hSpCas9 | negative selection | 7850132 | 19132632 | 19132655 | 17 | + | 27260156 | NCIH2009 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.1961546620802983 | [1192] | [1829,1201,1408] | -3 | hSpCas9 | negative selection | 7914385 | 19138455 | 19138478 | 17 | + | 27260156 | NCIH2009 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.8902259539034656 | [546] | [559,383,321] | -8 | hSpCas9 | negative selection | 7914392 | 19127610 | 19127633 | 17 | + | 27260156 | NCIH1373 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.48938031999003107 | [261] | [736,483,176,75] | 5 | hSpCas9 | negative selection | 7971383 | 19132632 | 19132655 | 17 | + | 27260156 | NCIH1373 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.2518617713866689 | [1192] | [1148,1039,1052,332] | -3 | hSpCas9 | negative selection | 8035636 | 19138455 | 19138478 | 17 | + | 27260156 | NCIH1373 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.6826427197874473 | [546] | [334,260,330,162] | -6 | hSpCas9 | negative selection | 8035643 | 19127610 | 19127633 | 17 | + | 27260156 | PATU8902 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.08510977770254358 | [261] | [412,544,242,380] | 0 | hSpCas9 | negative selection | 8092634 | 19132632 | 19132655 | 17 | + | 27260156 | PATU8902 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.13292360814234438 | [1192] | [1546,1865,1245,1452] | -1 | hSpCas9 | negative selection | 8156887 | 19138455 | 19138478 | 17 | + | 27260156 | PATU8902 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -1.3508086259094176 | [546] | [364,324,220,300] | -8 | hSpCas9 | negative selection | 8156894 | 19127610 | 19127633 | 17 | + | 27260156 | PANC1 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.2844665111639618 | [261] | [264,270,364,202] | 4 | hSpCas9 | negative selection | 8213885 | 19132632 | 19132655 | 17 | + | 27260156 | PANC1 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.596640068633391 | [1192] | [625,936,563,632] | -7 | hSpCas9 | negative selection | 8278138 | 19138455 | 19138478 | 17 | + | 27260156 | PANC1 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.8251778635480957 | [546] | [247,331,323,180] | -8 | hSpCas9 | negative selection | 8278145 | 19127610 | 19127633 | 17 | + | 27260156 | PANC0813 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.09764977761065963 | [261] | [312,306,276,256] | -2 | hSpCas9 | negative selection | 8335136 | 19132632 | 19132655 | 17 | + | 27260156 | PANC0813 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.10793117380279682 | [1192] | [1371,1341,1100,1384] | -2 | hSpCas9 | negative selection | 8399389 | 19138455 | 19138478 | 17 | + | 27260156 | PANC0813 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -1.02732696470696 | [546] | [344,297,233,381] | -8 | hSpCas9 | negative selection | 8399396 | 19127610 | 19127633 | 17 | + | 27260156 | RDES | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.1530491023303734 | [261] | [270,335,353,391] | 2 | hSpCas9 | negative selection | 8456387 | 19132632 | 19132655 | 17 | + | 27260156 | RDES | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.16382991353902487 | [1192] | [1043,1352,1215,1280] | -3 | hSpCas9 | negative selection | 8520640 | 19138455 | 19138478 | 17 | + | 27260156 | RDES | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.061651527296344516 | [546] | [477,527,759,678] | -1 | hSpCas9 | negative selection | 8520647 | 19127610 | 19127633 | 17 | + | 27260156 | PC3 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.046504502200594544 | [261] | [178,280,522,202] | 1 | hSpCas9 | negative selection | 8577638 | 19132632 | 19132655 | 17 | + | 27260156 | PC3 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | 0.08402831459843618 | [1192] | [556,1185,2613,1443] | 2 | hSpCas9 | negative selection | 8641891 | 19138455 | 19138478 | 17 | + | 27260156 | PC3 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.44567407963099775 | [546] | [195,476,627,443] | -7 | hSpCas9 | negative selection | 8641898 | 19127610 | 19127633 | 17 | + | 27260156 | PATU8988T | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.18027359712630586 | [261] | [193,348,145,216] | -3 | hSpCas9 | negative selection | 8698889 | 19132632 | 19132655 | 17 | + | 27260156 | PATU8988T | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.23021667148482217 | [1192] | [901,1072,896,1075] | -4 | hSpCas9 | negative selection | 8763142 | 19138455 | 19138478 | 17 | + | 27260156 | PATU8988T | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.9635100404467067 | [546] | [163,457,233,243] | -8 | hSpCas9 | negative selection | 8763149 | 19127610 | 19127633 | 17 | + | 27260156 | T47D | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.0009633087368570159 | [261] | [240,246,419,316] | 0 | hSpCas9 | negative selection | 8820140 | 19132632 | 19132655 | 17 | + | 27260156 | T47D | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.25609680595913087 | [1192] | [1161,965,1164,1385] | -5 | hSpCas9 | negative selection | 8884393 | 19138455 | 19138478 | 17 | + | 27260156 | T47D | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.6076774686245884 | [546] | [406,471,363,425] | -8 | hSpCas9 | negative selection | 8884400 | 19127610 | 19127633 | 17 | + | 27260156 | SU8686 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.10791518695968283 | [261] | [340,245,247,278] | 1 | hSpCas9 | negative selection | 8941391 | 19132632 | 19132655 | 17 | + | 27260156 | SU8686 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.10222509470657393 | [1192] | [944,1074,1069,1373] | -2 | hSpCas9 | negative selection | 9005644 | 19138455 | 19138478 | 17 | + | 27260156 | SU8686 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.44360605663211705 | [546] | [398,317,352,556] | -6 | hSpCas9 | negative selection | 9005651 | 19127610 | 19127633 | 17 | + | 27260156 | SKES1 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.12607303108154622 | [261] | [290,255,216,204] | -3 | hSpCas9 | negative selection | 9062642 | 19132632 | 19132655 | 17 | + | 27260156 | SKES1 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.2308995969330323 | [1192] | [1267,1056,933,847] | -5 | hSpCas9 | negative selection | 9126895 | 19138455 | 19138478 | 17 | + | 27260156 | SKES1 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.5786798571706484 | [546] | [366,553,323,249] | -8 | hSpCas9 | negative selection | 9126902 | 19127610 | 19127633 | 17 | + | 27260156 | TOV112D | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.07017699481284312 | [261] | [281,314,247,266] | 1 | hSpCas9 | negative selection | 9183893 | 19132632 | 19132655 | 17 | + | 27260156 | TOV112D | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.09763670085443032 | [1192] | [1296,1581,906,816] | -2 | hSpCas9 | negative selection | 9248146 | 19138455 | 19138478 | 17 | + | 27260156 | TOV112D | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.4567691462274207 | [546] | [392,356,358,473] | -7 | hSpCas9 | negative selection | 9248153 | 19127610 | 19127633 | 17 | + | 27260156 | TC71 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.09085107867835385 | [261] | [193,290,295,274] | -2 | hSpCas9 | negative selection | 9305144 | 19132632 | 19132655 | 17 | + | 27260156 | TC71 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.15118344475896794 | [1192] | [1292,1049,1074,1189] | -4 | hSpCas9 | negative selection | 9369397 | 19138455 | 19138478 | 17 | + | 27260156 | TC71 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.3359307255543526 | [546] | [497,390,374,604] | -7 | hSpCas9 | negative selection | 9369404 | 19127610 | 19127633 | 17 | + | 27260156 | TC32 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.008796114801492672 | [261] | [342,138,276,250] | 0 | hSpCas9 | negative selection | 9426395 | 19132632 | 19132655 | 17 | + | 27260156 | TC32 | viability | CTGCCCACAGATCCTGAACATGG | GRAPL | ENSG00000189152 | -0.08959611596163342 | [1192] | [900,823,1418,1184] | -1 | hSpCas9 | negative selection | 9490648 | 19138455 | 19138478 | 17 | + | 27260156 | TC32 | viability | TCTCTCCGCAGGTGGTACTCGGG | GRAPL | ENSG00000189152 | -0.8095567817645677 | [546] | [392,115,333,379] | -9 | hSpCas9 | negative selection | 9490655 | 19138546 | 19138569 | 17 | + | 28162770 | P31FUJ | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | 0.7671977955856213 | [95] | [191] | 8 | hSpCas9 | negative selection | 10165493 | 19127649 | 19127672 | 17 | + | 28162770 | P31FUJ | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | -1.3860484647100608 | [128] | [57] | -7 | hSpCas9 | negative selection | 10165494 | 19138562 | 19138585 | 17 | - | 28162770 | P31FUJ | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | 0.0834571403862916 | [203] | [253] | 0 | hSpCas9 | negative selection | 10165495 | 19127662 | 19127685 | 17 | + | 28162770 | P31FUJ | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -1.554730299301741 | [374] | [149] | -7 | hSpCas9 | negative selection | 10165496 | 19138487 | 19138510 | 17 | - | 28162770 | P31FUJ | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -1.010409783077931 | [47] | [27] | -6 | hSpCas9 | negative selection | 10165497 | 19127610 | 19127633 | 17 | + | 28162770 | P31FUJ | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.7853432274431573 | [109] | [74] | -6 | hSpCas9 | negative selection | 10165498 | 19127676 | 19127699 | 17 | + | 28162770 | P31FUJ | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | -0.2826910802067377 | [558] | [539] | -3 | hSpCas9 | negative selection | 10165499 | 19132722 | 19132745 | 17 | - | 28162770 | P31FUJ | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.8400338689765675 | [456] | [299] | -6 | hSpCas9 | negative selection | 10165500 | 19138523 | 19138546 | 17 | - | 28162770 | P31FUJ | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -1.312972553098362 | [147] | [69] | -7 | hSpCas9 | negative selection | 10165501 | 19127627 | 19127650 | 17 | - | 28162770 | P31FUJ | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 0.3501880539751725 | [487] | [730] | 4 | hSpCas9 | negative selection | 10165502 | 19138546 | 19138569 | 17 | + | 28162770 | TF1 | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | NaN | [NaN] | [83] | 1 | hSpCas9 | negative selection | 10334859 | 19127649 | 19127672 | 17 | + | 28162770 | TF1 | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | NaN | [NaN] | [72] | 1 | hSpCas9 | negative selection | 10334860 | 19138562 | 19138585 | 17 | - | 28162770 | TF1 | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | NaN | [NaN] | [151] | 1 | hSpCas9 | negative selection | 10334861 | 19127662 | 19127685 | 17 | + | 28162770 | TF1 | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | NaN | [NaN] | [118] | 1 | hSpCas9 | negative selection | 10334862 | 19138487 | 19138510 | 17 | - | 28162770 | TF1 | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | NaN | [NaN] | [55] | 1 | hSpCas9 | negative selection | 10334863 | 19127610 | 19127633 | 17 | + | 28162770 | TF1 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | NaN | [NaN] | [28] | 1 | hSpCas9 | negative selection | 10334864 | 19127676 | 19127699 | 17 | + | 28162770 | TF1 | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | NaN | [NaN] | [325] | 1 | hSpCas9 | negative selection | 10334865 | 19132722 | 19132745 | 17 | - | 28162770 | TF1 | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | NaN | [NaN] | [358] | 1 | hSpCas9 | negative selection | 10334866 | 19138523 | 19138546 | 17 | - | 28162770 | TF1 | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | NaN | [NaN] | [159] | 1 | hSpCas9 | negative selection | 10334867 | 19127627 | 19127650 | 17 | - | 28162770 | TF1 | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | NaN | [NaN] | [715] | 1 | hSpCas9 | negative selection | 10334868 | 19138546 | 19138569 | 17 | + | 28162770 | SKM1 | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | 0.008073300535682115 | [17] | [31] | 0 | hSpCas9 | negative selection | 10504225 | 19127649 | 19127672 | 17 | + | 28162770 | SKM1 | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | 0.08488889758651319 | [23] | [44] | 0 | hSpCas9 | negative selection | 10504226 | 19138562 | 19138585 | 17 | - | 28162770 | SKM1 | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | -0.0752881273042372 | [58] | [98] | 0 | hSpCas9 | negative selection | 10504227 | 19127662 | 19127685 | 17 | + | 28162770 | SKM1 | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -2.0490706065679265 | [102] | [43] | -8 | hSpCas9 | negative selection | 10504228 | 19138487 | 19138510 | 17 | - | 28162770 | SKM1 | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | 1.85042364394949 | [7] | [50] | 9 | hSpCas9 | negative selection | 10504229 | 19127610 | 19127633 | 17 | + | 28162770 | SKM1 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -2.0199410756339145 | [38] | [16] | -8 | hSpCas9 | negative selection | 10504230 | 19127676 | 19127699 | 17 | + | 28162770 | SKM1 | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | 0.1714849950193199 | [110] | [220] | 1 | hSpCas9 | negative selection | 10504231 | 19132722 | 19132745 | 17 | - | 28162770 | SKM1 | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -1.1200830509550002 | [74] | [60] | -7 | hSpCas9 | negative selection | 10504232 | 19138523 | 19138546 | 17 | - | 28162770 | SKM1 | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -1.9000042100232788 | [37] | [17] | -8 | hSpCas9 | negative selection | 10504233 | 19127627 | 19127650 | 17 | - | 28162770 | SKM1 | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 0.3321214472974139 | [101] | [226] | 3 | hSpCas9 | negative selection | 10504234 | 19138546 | 19138569 | 17 | + | 28162770 | SKM1 | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | 0.008073300535682115 | [17] | [31] | 0 | hSpCas9 | negative selection | 10673591 | 19127649 | 19127672 | 17 | + | 28162770 | SKM1 | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | 0.08488889758651319 | [23] | [44] | 0 | hSpCas9 | negative selection | 10673592 | 19138562 | 19138585 | 17 | - | 28162770 | SKM1 | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | -0.0752881273042372 | [58] | [98] | 0 | hSpCas9 | negative selection | 10673593 | 19127662 | 19127685 | 17 | + | 28162770 | SKM1 | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -2.0490706065679265 | [102] | [43] | -8 | hSpCas9 | negative selection | 10673594 | 19138487 | 19138510 | 17 | - | 28162770 | SKM1 | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | 1.85042364394949 | [7] | [50] | 9 | hSpCas9 | negative selection | 10673595 | 19127610 | 19127633 | 17 | + | 28162770 | SKM1 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -2.0199410756339145 | [38] | [16] | -8 | hSpCas9 | negative selection | 10673596 | 19127676 | 19127699 | 17 | + | 28162770 | SKM1 | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | 0.1714849950193199 | [110] | [220] | 1 | hSpCas9 | negative selection | 10673597 | 19132722 | 19132745 | 17 | - | 28162770 | SKM1 | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -1.1200830509550002 | [74] | [60] | -7 | hSpCas9 | negative selection | 10673598 | 19138523 | 19138546 | 17 | - | 28162770 | SKM1 | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -1.9000042100232788 | [37] | [17] | -8 | hSpCas9 | negative selection | 10673599 | 19127627 | 19127650 | 17 | - | 28162770 | SKM1 | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 0.3321214472974139 | [101] | [226] | 3 | hSpCas9 | negative selection | 10673600 | 19138546 | 19138569 | 17 | + | 28162770 | PL21 | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | 1.5459144513310503 | [95] | [121] | 9 | hSpCas9 | negative selection | 10842957 | 19127649 | 19127672 | 17 | + | 28162770 | PL21 | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | 0.30447627430405577 | [79] | [42] | 2 | hSpCas9 | negative selection | 10842958 | 19138562 | 19138585 | 17 | - | 28162770 | PL21 | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | -0.2505217945202452 | [245] | [89] | -2 | hSpCas9 | negative selection | 10842959 | 19127662 | 19127685 | 17 | + | 28162770 | PL21 | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -0.24646796379039332 | [307] | [112] | -2 | hSpCas9 | negative selection | 10842960 | 19138487 | 19138510 | 17 | - | 28162770 | PL21 | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | 1.749478205479755 | [40] | [59] | 9 | hSpCas9 | negative selection | 10842961 | 19127610 | 19127633 | 17 | + | 28162770 | PL21 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -1.7327461896521428 | [167] | [21] | -8 | hSpCas9 | negative selection | 10842962 | 19127676 | 19127699 | 17 | + | 28162770 | PL21 | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | 0.493135217764185 | [412] | [252] | 4 | hSpCas9 | negative selection | 10842963 | 19132722 | 19132745 | 17 | - | 28162770 | PL21 | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | 0.16391942657656677 | [241] | [117] | 1 | hSpCas9 | negative selection | 10842964 | 19138523 | 19138546 | 17 | - | 28162770 | PL21 | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -1.4891595460465719 | [128] | [19] | -7 | hSpCas9 | negative selection | 10842965 | 19127627 | 19127650 | 17 | - | 28162770 | PL21 | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 0.055516051409867595 | [324] | [146] | 0 | hSpCas9 | negative selection | 10842966 | 19138546 | 19138569 | 17 | + | 28162770 | P31FUJ | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | 0.7671977955856213 | [95] | [191] | 8 | hSpCas9 | negative selection | 11012323 | 19127649 | 19127672 | 17 | + | 28162770 | P31FUJ | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | -1.3860484647100608 | [128] | [57] | -7 | hSpCas9 | negative selection | 11012324 | 19138562 | 19138585 | 17 | - | 28162770 | P31FUJ | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | 0.0834571403862916 | [203] | [253] | 0 | hSpCas9 | negative selection | 11012325 | 19127662 | 19127685 | 17 | + | 28162770 | P31FUJ | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -1.554730299301741 | [374] | [149] | -7 | hSpCas9 | negative selection | 11012326 | 19138487 | 19138510 | 17 | - | 28162770 | P31FUJ | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -1.010409783077931 | [47] | [27] | -6 | hSpCas9 | negative selection | 11012327 | 19127610 | 19127633 | 17 | + | 28162770 | P31FUJ | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.7853432274431573 | [109] | [74] | -6 | hSpCas9 | negative selection | 11012328 | 19127676 | 19127699 | 17 | + | 28162770 | P31FUJ | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | -0.2826910802067377 | [558] | [539] | -3 | hSpCas9 | negative selection | 11012329 | 19132722 | 19132745 | 17 | - | 28162770 | P31FUJ | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.8400338689765675 | [456] | [299] | -6 | hSpCas9 | negative selection | 11012330 | 19138523 | 19138546 | 17 | - | 28162770 | P31FUJ | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -1.312972553098362 | [147] | [69] | -7 | hSpCas9 | negative selection | 11012331 | 19127627 | 19127650 | 17 | - | 28162770 | P31FUJ | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 0.3501880539751725 | [487] | [730] | 4 | hSpCas9 | negative selection | 11012332 | 19138546 | 19138569 | 17 | + | 28162770 | OCIAML5 | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | 0.5422123682480495 | [34] | [91] | 5 | hSpCas9 | negative selection | 11181689 | 19127649 | 19127672 | 17 | + | 28162770 | OCIAML5 | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | -0.9616910620384951 | [40] | [37] | -6 | hSpCas9 | negative selection | 11181690 | 19138562 | 19138585 | 17 | - | 28162770 | OCIAML5 | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | 0.055569410987343415 | [128] | [241] | 0 | hSpCas9 | negative selection | 11181691 | 19127662 | 19127685 | 17 | + | 28162770 | OCIAML5 | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -0.5719586516712617 | [167] | [203] | -4 | hSpCas9 | negative selection | 11181692 | 19138487 | 19138510 | 17 | - | 28162770 | OCIAML5 | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | 1.5767767279398772 | [12] | [69] | 9 | hSpCas9 | negative selection | 11181693 | 19127610 | 19127633 | 17 | + | 28162770 | OCIAML5 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -1.2671040701428409 | [75] | [56] | -6 | hSpCas9 | negative selection | 11181694 | 19127676 | 19127699 | 17 | + | 28162770 | OCIAML5 | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | 0.08546934218934954 | [235] | [451] | 0 | hSpCas9 | negative selection | 11181695 | 19132722 | 19132745 | 17 | - | 28162770 | OCIAML5 | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.5335370524384995 | [169] | [211] | -4 | hSpCas9 | negative selection | 11181696 | 19138523 | 19138546 | 17 | - | 28162770 | OCIAML5 | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -1.342392197447078 | [58] | [41] | -7 | hSpCas9 | negative selection | 11181697 | 19127627 | 19127650 | 17 | - | 28162770 | OCIAML5 | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 0.41642226506190505 | [219] | [529] | 3 | hSpCas9 | negative selection | 11181698 | 19138546 | 19138569 | 17 | + | 28162770 | EOL1 | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | 0.8022920215195366 | [159] | [146] | 7 | hSpCas9 | negative selection | 11351055 | 19127649 | 19127672 | 17 | + | 28162770 | EOL1 | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | -0.2260119050048468 | [110] | [49] | -2 | hSpCas9 | negative selection | 11351056 | 19138562 | 19138585 | 17 | - | 28162770 | EOL1 | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | 0.18557285251004207 | [478] | [286] | 1 | hSpCas9 | negative selection | 11351057 | 19127662 | 19127685 | 17 | + | 28162770 | EOL1 | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -0.9073294696211385 | [533] | [149] | -6 | hSpCas9 | negative selection | 11351058 | 19138487 | 19138510 | 17 | - | 28162770 | EOL1 | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -2.577952568958649 | [67] | [5] | -9 | hSpCas9 | negative selection | 11351059 | 19127610 | 19127633 | 17 | + | 28162770 | EOL1 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.4351823560292124 | [289] | [112] | -3 | hSpCas9 | negative selection | 11351060 | 19127676 | 19127699 | 17 | + | 28162770 | EOL1 | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | -0.6155331304697775 | [537] | [184] | -4 | hSpCas9 | negative selection | 11351061 | 19132722 | 19132745 | 17 | - | 28162770 | EOL1 | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | 0.5642532368861228 | [361] | [281] | 5 | hSpCas9 | negative selection | 11351062 | 19138523 | 19138546 | 17 | - | 28162770 | EOL1 | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -1.1507403557337026 | [117] | [27] | -6 | hSpCas9 | negative selection | 11351063 | 19127627 | 19127650 | 17 | - | 28162770 | EOL1 | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 0.2551930835590057 | [527] | [331] | 2 | hSpCas9 | negative selection | 11351064 | 19138546 | 19138569 | 17 | + | 28162770 | MOLM13 | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | 1.3595132204997866 | [75] | [140] | 9 | hSpCas9 | negative selection | 11520421 | 19127649 | 19127672 | 17 | + | 28162770 | MOLM13 | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | -3.2201666121406807 | [115] | [8] | -8 | hSpCas9 | negative selection | 11520422 | 19138562 | 19138585 | 17 | - | 28162770 | MOLM13 | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | -0.4127385292503378 | [312] | [169] | -2 | hSpCas9 | negative selection | 11520423 | 19127662 | 19127685 | 17 | + | 28162770 | MOLM13 | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -0.9171355486678254 | [443] | [169] | -5 | hSpCas9 | negative selection | 11520424 | 19138487 | 19138510 | 17 | - | 28162770 | MOLM13 | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | 0.3542325997490119 | [65] | [60] | 2 | hSpCas9 | negative selection | 11520425 | 19127610 | 19127633 | 17 | + | 28162770 | MOLM13 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 0.34759514782686707 | [149] | [137] | 2 | hSpCas9 | negative selection | 11520426 | 19127676 | 19127699 | 17 | + | 28162770 | MOLM13 | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | -0.298331436817167 | [630] | [370] | -2 | hSpCas9 | negative selection | 11520427 | 19132722 | 19132745 | 17 | - | 28162770 | MOLM13 | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.1376700237836908 | [387] | [254] | -1 | hSpCas9 | negative selection | 11520428 | 19138523 | 19138546 | 17 | - | 28162770 | MOLM13 | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -4.965070025731528 | [215] | [4] | -9 | hSpCas9 | negative selection | 11520429 | 19127627 | 19127650 | 17 | - | 28162770 | MOLM13 | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | -0.1828109164181787 | [448] | [285] | -1 | hSpCas9 | negative selection | 11520430 | 19138546 | 19138569 | 17 | + | 28162770 | HEL | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | -0.5967271026950323 | [84] | [35] | -4 | hSpCas9 | negative selection | 11689787 | 19127649 | 19127672 | 17 | + | 28162770 | HEL | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | 0.08162307323356854 | [89] | [60] | 0 | hSpCas9 | negative selection | 11689788 | 19138562 | 19138585 | 17 | - | 28162770 | HEL | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | -0.04531716168490271 | [289] | [179] | 0 | hSpCas9 | negative selection | 11689789 | 19127662 | 19127685 | 17 | + | 28162770 | HEL | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -1.3886253389089784 | [371] | [90] | -7 | hSpCas9 | negative selection | 11689790 | 19138487 | 19138510 | 17 | - | 28162770 | HEL | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | 2.2948155285800502 | [34] | [109] | 9 | hSpCas9 | negative selection | 11689791 | 19127610 | 19127633 | 17 | + | 28162770 | HEL | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.5315120948447456 | [166] | [73] | -4 | hSpCas9 | negative selection | 11689792 | 19127676 | 19127699 | 17 | + | 28162770 | HEL | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | 0.27521025829545753 | [457] | [354] | 2 | hSpCas9 | negative selection | 11689793 | 19132722 | 19132745 | 17 | - | 28162770 | HEL | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -1.3952290181986635 | [307] | [74] | -7 | hSpCas9 | negative selection | 11689794 | 19138523 | 19138546 | 17 | - | 28162770 | HEL | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -2.0055496040896283 | [162] | [25] | -8 | hSpCas9 | negative selection | 11689795 | 19127627 | 19127650 | 17 | - | 28162770 | HEL | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 0.522444598282645 | [374] | [344] | 4 | hSpCas9 | negative selection | 11689796 | 19138546 | 19138569 | 17 | + | 28162770 | MV411 | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | 0.8464752367156544 | [67] | [102] | 7 | hSpCas9 | negative selection | 11859153 | 19127649 | 19127672 | 17 | + | 28162770 | MV411 | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | -0.011949078035874194 | [78] | [65] | 0 | hSpCas9 | negative selection | 11859154 | 19138562 | 19138585 | 17 | - | 28162770 | MV411 | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | -0.11603280634777091 | [228] | [177] | -1 | hSpCas9 | negative selection | 11859155 | 19127662 | 19127685 | 17 | + | 28162770 | MV411 | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -2.763561448166482 | [394] | [48] | -9 | hSpCas9 | negative selection | 11859156 | 19138487 | 19138510 | 17 | - | 28162770 | MV411 | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | 0.21769020738872324 | [48] | [47] | 2 | hSpCas9 | negative selection | 11859157 | 19127610 | 19127633 | 17 | + | 28162770 | MV411 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.5719902035754039 | [119] | [67] | -4 | hSpCas9 | negative selection | 11859158 | 19127676 | 19127699 | 17 | + | 28162770 | MV411 | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | -0.020975034777585444 | [429] | [356] | 0 | hSpCas9 | negative selection | 11859159 | 19132722 | 19132745 | 17 | - | 28162770 | MV411 | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.6182613575056336 | [245] | [134] | -4 | hSpCas9 | negative selection | 11859160 | 19138523 | 19138546 | 17 | - | 28162770 | MV411 | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -1.4107739319690193 | [100] | [31] | -7 | hSpCas9 | negative selection | 11859161 | 19127627 | 19127650 | 17 | - | 28162770 | MV411 | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 0.7847470759125159 | [276] | [401] | 7 | hSpCas9 | negative selection | 11859162 | 19138546 | 19138569 | 17 | + | 28162770 | MONOMAC1 | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | -0.8600018597819832 | [56] | [35] | -6 | hSpCas9 | negative selection | 12028519 | 19127649 | 19127672 | 17 | + | 28162770 | MONOMAC1 | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | -0.3940736941191074 | [46] | [40] | -3 | hSpCas9 | negative selection | 12028520 | 19138562 | 19138585 | 17 | - | 28162770 | MONOMAC1 | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | 0.0017430170549439516 | [175] | [201] | 0 | hSpCas9 | negative selection | 12028521 | 19127662 | 19127685 | 17 | + | 28162770 | MONOMAC1 | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -1.2605397893657118 | [208] | [99] | -7 | hSpCas9 | negative selection | 12028522 | 19138487 | 19138510 | 17 | - | 28162770 | MONOMAC1 | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | 1.5514243859444816 | [24] | [83] | 9 | hSpCas9 | negative selection | 12028523 | 19127610 | 19127633 | 17 | + | 28162770 | MONOMAC1 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.31952085358454874 | [85] | [78] | -3 | hSpCas9 | negative selection | 12028524 | 19127676 | 19127699 | 17 | + | 28162770 | MONOMAC1 | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | 0.3810392680763628 | [279] | [417] | 4 | hSpCas9 | negative selection | 12028525 | 19132722 | 19132745 | 17 | - | 28162770 | MONOMAC1 | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | 0.2272784658073007 | [154] | [207] | 2 | hSpCas9 | negative selection | 12028526 | 19138523 | 19138546 | 17 | - | 28162770 | MONOMAC1 | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -0.47575287512561726 | [73] | [60] | -4 | hSpCas9 | negative selection | 12028527 | 19127627 | 19127650 | 17 | - | 28162770 | MONOMAC1 | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 0.4480062576656132 | [242] | [379] | 4 | hSpCas9 | negative selection | 12028528 | 19138546 | 19138569 | 17 | + | 28162770 | OCIAML2 | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | -0.1013960155764424 | [11] | [61] | -1 | hSpCas9 | negative selection | 12197885 | 19127649 | 19127672 | 17 | + | 28162770 | OCIAML2 | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | 0.17322636453256313 | [7] | [49] | 1 | hSpCas9 | negative selection | 12197886 | 19138562 | 19138585 | 17 | - | 28162770 | OCIAML2 | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | -0.7803143243747765 | [43] | [141] | -5 | hSpCas9 | negative selection | 12197887 | 19127662 | 19127685 | 17 | + | 28162770 | OCIAML2 | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -0.8691792017324361 | [57] | [175] | -6 | hSpCas9 | negative selection | 12197888 | 19138487 | 19138510 | 17 | - | 28162770 | OCIAML2 | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -1.4035156293836244 | [20] | [43] | -7 | hSpCas9 | negative selection | 12197889 | 19127610 | 19127633 | 17 | + | 28162770 | OCIAML2 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | -0.18238485661108755 | [25] | [126] | -1 | hSpCas9 | negative selection | 12197890 | 19127676 | 19127699 | 17 | + | 28162770 | OCIAML2 | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | -0.24556326960738806 | [76] | [359] | -2 | hSpCas9 | negative selection | 12197891 | 19132722 | 19132745 | 17 | - | 28162770 | OCIAML2 | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | 0.4426585415645081 | [29] | [225] | 4 | hSpCas9 | negative selection | 12197892 | 19138523 | 19138546 | 17 | - | 28162770 | OCIAML2 | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | -3.0555923259633175 | [26] | [17] | -9 | hSpCas9 | negative selection | 12197893 | 19127627 | 19127650 | 17 | - | 28162770 | OCIAML2 | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | -0.2605157336841499 | [58] | [272] | -2 | hSpCas9 | negative selection | 12197894 | 19138546 | 19138569 | 17 | + | 28162770 | OCIAML3 | viability | GGGAGAGTGAGAGCTCCCCAGGG | GRAPL | ENSG00000189152 | 1.2727258288123728 | [16] | [123] | 9 | hSpCas9 | negative selection | 12367251 | 19127649 | 19127672 | 17 | + | 28162770 | OCIAML3 | viability | GGCTACAGAGAGCGACGAGCTGG | GRAPL | ENSG00000189152 | -0.28734630209011125 | [18] | [46] | -2 | hSpCas9 | negative selection | 12367252 | 19138562 | 19138585 | 17 | - | 28162770 | OCIAML3 | viability | CAGACACAGAGAACTCCCCTGGG | GRAPL | ENSG00000189152 | -0.5433815672541952 | [55] | [115] | -4 | hSpCas9 | negative selection | 12367253 | 19127662 | 19127685 | 17 | + | 28162770 | OCIAML3 | viability | GACGAGCTGGCCTTCAACAAGGG | GRAPL | ENSG00000189152 | -1.1789701410453195 | [68] | [91] | -7 | hSpCas9 | negative selection | 12367254 | 19138487 | 19138510 | 17 | - | 28162770 | OCIAML3 | viability | GAATCTCTTCGGCCAGCTGCCGG | GRAPL | ENSG00000189152 | -1.4013625623817672 | [13] | [15] | -7 | hSpCas9 | negative selection | 12367255 | 19127610 | 19127633 | 17 | + | 28162770 | OCIAML3 | viability | GAGCAGCGGCATGGAGTCCGTGG | GRAPL | ENSG00000189152 | 1.3987607904447608 | [24] | [198] | 9 | hSpCas9 | negative selection | 12367256 | 19127676 | 19127699 | 17 | + | 28162770 | OCIAML3 | viability | CAACAAGGGAGACACACTCAAGG | GRAPL | ENSG00000189152 | -0.24099186765270375 | [100] | [257] | -2 | hSpCas9 | negative selection | 12367257 | 19132722 | 19132745 | 17 | - | 28162770 | OCIAML3 | viability | CTCACGGATGGGGCTTGACGCGG | GRAPL | ENSG00000189152 | -0.3529995408203683 | [87] | [207] | -3 | hSpCas9 | negative selection | 12367258 | 19138523 | 19138546 | 17 | - | 28162770 | OCIAML3 | viability | GGATCAGGAAGGCTCCCAGATGG | GRAPL | ENSG00000189152 | 0.061344188288390944 | [19] | [62] | 0 | hSpCas9 | negative selection | 12367259 | 19127627 | 19127650 | 17 | - | 28162770 | OCIAML3 | viability | CTGAAAGCTGTACAGGGCCACGG | GRAPL | ENSG00000189152 | 1.2241540366900239 | [94] | [669] | 8 | hSpCas9 | negative selection | 12367260 |