| 112279290 | 112279313 | 12 | - | 26627737 | DLD1 | viability | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -0.20514598518471594 | [266] | [66,57,88] | -2 | hSpCas9 | negative selection | 782255 | 112283156 | 112283179 | 12 | + | 26627737 | DLD1 | viability | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | -0.8526771616599431 | [113] | [21,10,24] | -7 | hSpCas9 | negative selection | 782256 | 112306175 | 112306198 | 12 | + | 26627737 | DLD1 | viability | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | 0.2530449824541887 | [154] | [75,82,20] | 2 | hSpCas9 | negative selection | 782257 | 112308816 | 112308839 | 12 | - | 26627737 | DLD1 | viability | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 0.029305802863653696 | [688] | [216,399,72] | 0 | hSpCas9 | negative selection | 782258 | 112314461 | 112314484 | 12 | + | 26627737 | DLD1 | viability | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 1.2673025871832018 | [131] | [70,167,66] | 9 | hSpCas9 | negative selection | 782259 | 112319336 | 112319359 | 12 | + | 26627737 | DLD1 | viability | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | -0.2157902686366664 | [120] | [25,50,22] | -2 | hSpCas9 | negative selection | 782260 | 112279290 | 112279313 | 12 | - | 26627737 | GBM cells | viability after 5 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -0.2114095400203131 | [162] | [89,60] | -3 | hSpCas9 | negative selection | 864570 | 112283156 | 112283179 | 12 | + | 26627737 | GBM cells | viability after 5 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | 1.9462195896640422 | [29] | [61,61] | 9 | hSpCas9 | negative selection | 864571 | 112306175 | 112306198 | 12 | + | 26627737 | GBM cells | viability after 5 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | 0.303304129965021 | [101] | [59,74] | 5 | hSpCas9 | negative selection | 864572 | 112308816 | 112308839 | 12 | - | 26627737 | GBM cells | viability after 5 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 0.2208419697730481 | [215] | [136,132] | 3 | hSpCas9 | negative selection | 864573 | 112314461 | 112314484 | 12 | + | 26627737 | GBM cells | viability after 5 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | -0.4591336458083288 | [181] | [57,83] | -6 | hSpCas9 | negative selection | 864574 | 112319336 | 112319359 | 12 | + | 26627737 | GBM cells | viability after 5 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | -0.13211302073493902 | [93] | [47,43] | -2 | hSpCas9 | negative selection | 864575 | 112279290 | 112279313 | 12 | - | 26627737 | GBM cells | viability after 13 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -0.2673857325074621 | [162] | [62,81] | -3 | hSpCas9 | negative selection | 946885 | 112283156 | 112283179 | 12 | + | 26627737 | GBM cells | viability after 13 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | 1.0450966220824323 | [29] | [37,29] | 9 | hSpCas9 | negative selection | 946886 | 112306175 | 112306198 | 12 | + | 26627737 | GBM cells | viability after 13 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | -0.43665643783869057 | [101] | [25,52] | -5 | hSpCas9 | negative selection | 946887 | 112308816 | 112308839 | 12 | - | 26627737 | GBM cells | viability after 13 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 0.24072799186928445 | [215] | [202,85] | 3 | hSpCas9 | negative selection | 946888 | 112314461 | 112314484 | 12 | + | 26627737 | GBM cells | viability after 13 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | -0.8664886759708502 | [181] | [30,72] | -7 | hSpCas9 | negative selection | 946889 | 112319336 | 112319359 | 12 | + | 26627737 | GBM cells | viability after 13 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | -0.6507708659942546 | [93] | [37,27] | -6 | hSpCas9 | negative selection | 946890 | 112279290 | 112279313 | 12 | - | 26627737 | GBM cells | viability after 21 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | 0.01083632145958302 | [162] | [83,93] | 0 | hSpCas9 | negative selection | 1029200 | 112283156 | 112283179 | 12 | + | 26627737 | GBM cells | viability after 21 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | 0.4063021112832459 | [29] | [30,12] | 4 | hSpCas9 | negative selection | 1029201 | 112306175 | 112306198 | 12 | + | 26627737 | GBM cells | viability after 21 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | 0.39389467770462894 | [101] | [88,57] | 4 | hSpCas9 | negative selection | 1029202 | 112308816 | 112308839 | 12 | - | 26627737 | GBM cells | viability after 21 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | -0.36018122035255107 | [215] | [104,78] | -3 | hSpCas9 | negative selection | 1029203 | 112314461 | 112314484 | 12 | + | 26627737 | GBM cells | viability after 21 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 0.06855615507148655 | [181] | [110,96] | 0 | hSpCas9 | negative selection | 1029204 | 112319336 | 112319359 | 12 | + | 26627737 | GBM cells | viability after 21 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | -1.285094687716557 | [93] | [21,19] | -8 | hSpCas9 | negative selection | 1029205 | 112279290 | 112279313 | 12 | - | 26627737 | RPE1 | viability after 9 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -2.0143248653072363 | [481] | [25,51] | -8 | hSpCas9 | negative selection | 1111515 | 112283156 | 112283179 | 12 | + | 26627737 | RPE1 | viability after 9 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | -1.6212738087469758 | [341] | [60,0] | -8 | hSpCas9 | negative selection | 1111516 | 112306175 | 112306198 | 12 | + | 26627737 | RPE1 | viability after 9 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | -0.31789310771504464 | [416] | [33,195] | -2 | hSpCas9 | negative selection | 1111517 | 112308816 | 112308839 | 12 | - | 26627737 | RPE1 | viability after 9 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 0.09493306356572107 | [1098] | [442,269] | 0 | hSpCas9 | negative selection | 1111518 | 112314461 | 112314484 | 12 | + | 26627737 | RPE1 | viability after 9 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 3.051356784869344 | [85] | [103,376] | 9 | hSpCas9 | negative selection | 1111519 | 112319336 | 112319359 | 12 | + | 26627737 | RPE1 | viability after 9 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 5.902367472667805 | [1] | [43,28] | 9 | hSpCas9 | negative selection | 1111520 | 112279290 | 112279313 | 12 | - | 26627737 | RPE1 | viability after 12 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -1.3187182372676745 | [481] | [31,72] | -7 | hSpCas9 | negative selection | 1193830 | 112283156 | 112283179 | 12 | + | 26627737 | RPE1 | viability after 12 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | -2.7441335245492082 | [341] | [20,5] | -9 | hSpCas9 | negative selection | 1193831 | 112306175 | 112306198 | 12 | + | 26627737 | RPE1 | viability after 12 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | -0.575679645550603 | [416] | [63,86] | -4 | hSpCas9 | negative selection | 1193832 | 112308816 | 112308839 | 12 | - | 26627737 | RPE1 | viability after 12 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | -0.1377769823612337 | [1098] | [348,182] | -1 | hSpCas9 | negative selection | 1193833 | 112314461 | 112314484 | 12 | + | 26627737 | RPE1 | viability after 12 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 3.072306930733915 | [85] | [171,217] | 9 | hSpCas9 | negative selection | 1193834 | 112319336 | 112319359 | 12 | + | 26627737 | RPE1 | viability after 12 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 6.1623625301904745 | [1] | [37,38] | 9 | hSpCas9 | negative selection | 1193835 | 112279290 | 112279313 | 12 | - | 26627737 | RPE1 | viability after 15 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -0.14857288456527806 | [481] | [178,68] | -1 | hSpCas9 | negative selection | 1276145 | 112283156 | 112283179 | 12 | + | 26627737 | RPE1 | viability after 15 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | -4.446632380213286 | [341] | [7,0] | -9 | hSpCas9 | negative selection | 1276146 | 112306175 | 112306198 | 12 | + | 26627737 | RPE1 | viability after 15 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | -0.07689960086119885 | [416] | [120,102] | 0 | hSpCas9 | negative selection | 1276147 | 112308816 | 112308839 | 12 | - | 26627737 | RPE1 | viability after 15 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 0.20902180368734125 | [1098] | [423,296] | 1 | hSpCas9 | negative selection | 1276148 | 112314461 | 112314484 | 12 | + | 26627737 | RPE1 | viability after 15 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 2.437873928030463 | [85] | [113,148] | 9 | hSpCas9 | negative selection | 1276149 | 112319336 | 112319359 | 12 | + | 26627737 | RPE1 | viability after 15 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 6.868959165674057 | [1] | [86,45] | 9 | hSpCas9 | negative selection | 1276150 | 112279290 | 112279313 | 12 | - | 26627737 | RPE1 | viability after 18 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -1.2813068513867112 | [481] | [53,52] | -7 | hSpCas9 | negative selection | 1358460 | 112283156 | 112283179 | 12 | + | 26627737 | RPE1 | viability after 18 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | -2.872615381634673 | [341] | [0,24] | -9 | hSpCas9 | negative selection | 1358461 | 112306175 | 112306198 | 12 | + | 26627737 | RPE1 | viability after 18 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | 0.1822883758173366 | [416] | [176,74] | 1 | hSpCas9 | negative selection | 1358462 | 112308816 | 112308839 | 12 | - | 26627737 | RPE1 | viability after 18 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 0.44426148005181665 | [1098] | [462,339] | 3 | hSpCas9 | negative selection | 1358463 | 112314461 | 112314484 | 12 | + | 26627737 | RPE1 | viability after 18 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 3.5115481451149986 | [85] | [240,289] | 9 | hSpCas9 | negative selection | 1358464 | 112319336 | 112319359 | 12 | + | 26627737 | RPE1 | viability after 18 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 7.667667512622437 | [1] | [145,70] | 9 | hSpCas9 | negative selection | 1358465 | 112279290 | 112279313 | 12 | - | 26627737 | HeLa | viability after 8 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | 0.820014827995951 | [166] | [61,249,62] | 6 | hSpCas9 | negative selection | 1440775 | 112283156 | 112283179 | 12 | + | 26627737 | HeLa | viability after 8 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | 6.892440835934981 | [0] | [51,63,39] | 9 | hSpCas9 | negative selection | 1440776 | 112306175 | 112306198 | 12 | + | 26627737 | HeLa | viability after 8 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | -1.551007996099774 | [211] | [4,42,39] | -9 | hSpCas9 | negative selection | 1440777 | 112308816 | 112308839 | 12 | - | 26627737 | HeLa | viability after 8 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 0.23254411443159423 | [356] | [383,115,97] | 2 | hSpCas9 | negative selection | 1440778 | 112314461 | 112314484 | 12 | + | 26627737 | HeLa | viability after 8 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 0.2746335907220142 | [247] | [51,171,148] | 2 | hSpCas9 | negative selection | 1440779 | 112319336 | 112319359 | 12 | + | 26627737 | HeLa | viability after 8 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 1.6006106759513075 | [41] | [78,44,47] | 9 | hSpCas9 | negative selection | 1440780 | 112279290 | 112279313 | 12 | - | 26627737 | HeLa | viability after 12 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | 0.5629473491230893 | [166] | [144,36,131] | 5 | hSpCas9 | negative selection | 1523090 | 112283156 | 112283179 | 12 | + | 26627737 | HeLa | viability after 12 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | 6.952114369941562 | [0] | [0,79,67] | 9 | hSpCas9 | negative selection | 1523091 | 112306175 | 112306198 | 12 | + | 26627737 | HeLa | viability after 12 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | -0.24344453950343703 | [211] | [27,4,194] | -2 | hSpCas9 | negative selection | 1523092 | 112308816 | 112308839 | 12 | - | 26627737 | HeLa | viability after 12 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 0.07941442688986106 | [356] | [10,244,197] | 0 | hSpCas9 | negative selection | 1523093 | 112314461 | 112314484 | 12 | + | 26627737 | HeLa | viability after 12 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | -0.35439224926556423 | [247] | [82,113,39] | -3 | hSpCas9 | negative selection | 1523094 | 112319336 | 112319359 | 12 | + | 26627737 | HeLa | viability after 12 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 1.1609379204446122 | [41] | [22,47,43] | 8 | hSpCas9 | negative selection | 1523095 | 112279290 | 112279313 | 12 | - | 26627737 | HeLa | viability after 15 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | 0.20166083688148606 | [166] | [96,74,60] | 1 | hSpCas9 | negative selection | 1605405 | 112283156 | 112283179 | 12 | + | 26627737 | HeLa | viability after 15 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | 7.6082270741628095 | [0] | [0,53,192] | 9 | hSpCas9 | negative selection | 1605406 | 112306175 | 112306198 | 12 | + | 26627737 | HeLa | viability after 15 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | -1.3421323568502732 | [211] | [18,28,55] | -8 | hSpCas9 | negative selection | 1605407 | 112308816 | 112308839 | 12 | - | 26627737 | HeLa | viability after 15 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 0.5514095073287996 | [356] | [104,350,181] | 4 | hSpCas9 | negative selection | 1605408 | 112314461 | 112314484 | 12 | + | 26627737 | HeLa | viability after 15 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | -0.3939079161916883 | [247] | [88,92,45] | -3 | hSpCas9 | negative selection | 1605409 | 112319336 | 112319359 | 12 | + | 26627737 | HeLa | viability after 15 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 2.3830871565801943 | [41] | [35,97,137] | 9 | hSpCas9 | negative selection | 1605410 | 112279290 | 112279313 | 12 | - | 26627737 | HeLa | viability after 18 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | 0.14787593585964642 | [166] | [57,63,60] | 1 | hSpCas9 | negative selection | 1687720 | 112283156 | 112283179 | 12 | + | 26627737 | HeLa | viability after 18 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | 7.628240158502675 | [0] | [0,46,192] | 9 | hSpCas9 | negative selection | 1687721 | 112306175 | 112306198 | 12 | + | 26627737 | HeLa | viability after 18 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | -1.412644504761638 | [211] | [11,20,55] | -8 | hSpCas9 | negative selection | 1687722 | 112308816 | 112308839 | 12 | - | 26627737 | HeLa | viability after 18 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 0.5375494578289397 | [356] | [66,289,181] | 4 | hSpCas9 | negative selection | 1687723 | 112314461 | 112314484 | 12 | + | 26627737 | HeLa | viability after 18 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | -0.34383337245278933 | [247] | [64,76,45] | -3 | hSpCas9 | negative selection | 1687724 | 112319336 | 112319359 | 12 | + | 26627737 | HeLa | viability after 18 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 2.3940877371036247 | [41] | [23,82,137] | 9 | hSpCas9 | negative selection | 1687725 | 112279290 | 112279313 | 12 | - | 26627737 | HCT116 | viability after 6 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | 0.6772854745787686 | [451] | [63,140] | 4 | hSpCas9 | negative selection | 1770035 | 112283156 | 112283179 | 12 | + | 26627737 | HCT116 | viability after 6 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | 4.262177772381739 | [13] | [116,0] | 9 | hSpCas9 | negative selection | 1770036 | 112306175 | 112306198 | 12 | + | 26627737 | HCT116 | viability after 6 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | -0.22895431116840959 | [263] | [95,1] | -1 | hSpCas9 | negative selection | 1770037 | 112308816 | 112308839 | 12 | - | 26627737 | HCT116 | viability after 6 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 1.1609161826840382 | [577] | [489,44] | 6 | hSpCas9 | negative selection | 1770038 | 112314461 | 112314484 | 12 | + | 26627737 | HCT116 | viability after 6 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 1.224690100048364 | [229] | [137,54] | 6 | hSpCas9 | negative selection | 1770039 | 112319336 | 112319359 | 12 | + | 26627737 | HCT116 | viability after 6 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 3.7027145748000416 | [9] | [4,28] | 9 | hSpCas9 | negative selection | 1770040 | 112279290 | 112279313 | 12 | - | 26627737 | HCT116 | viability after 8 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -0.5224663351374723 | [97] | [36,56,18] | -6 | hSpCas9 | negative selection | 1852350 | 112283156 | 112283179 | 12 | + | 26627737 | HCT116 | viability after 8 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | 0.0627207935074392 | [84] | [61,36,47] | 0 | hSpCas9 | negative selection | 1852351 | 112306175 | 112306198 | 12 | + | 26627737 | HCT116 | viability after 8 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | 0.09724957742419105 | [108] | [75,55,60] | 1 | hSpCas9 | negative selection | 1852352 | 112308816 | 112308839 | 12 | - | 26627737 | HCT116 | viability after 8 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | -1.1793209827835773 | [542] | [125,117,151] | -8 | hSpCas9 | negative selection | 1852353 | 112314461 | 112314484 | 12 | + | 26627737 | HCT116 | viability after 8 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 1.2356214405990391 | [135] | [167,245,115] | 8 | hSpCas9 | negative selection | 1852354 | 112319336 | 112319359 | 12 | + | 26627737 | HCT116 | viability after 8 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 0.8547569816059146 | [44] | [58,48,26] | 7 | hSpCas9 | negative selection | 1852355 | 112279290 | 112279313 | 12 | - | 26627737 | HCT116 | viability after 9 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -0.024856396990199425 | [451] | [83,145] | 0 | hSpCas9 | negative selection | 1934665 | 112283156 | 112283179 | 12 | + | 26627737 | HCT116 | viability after 9 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | 1.0812961524811167 | [13] | [3,10] | 7 | hSpCas9 | negative selection | 1934666 | 112306175 | 112306198 | 12 | + | 26627737 | HCT116 | viability after 9 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | -1.3720549107273834 | [263] | [24,28] | -7 | hSpCas9 | negative selection | 1934667 | 112308816 | 112308839 | 12 | - | 26627737 | HCT116 | viability after 9 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | -0.23571936252017076 | [577] | [96,157] | -2 | hSpCas9 | negative selection | 1934668 | 112314461 | 112314484 | 12 | + | 26627737 | HCT116 | viability after 9 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 0.25447839390372007 | [229] | [65,78] | 2 | hSpCas9 | negative selection | 1934669 | 112319336 | 112319359 | 12 | + | 26627737 | HCT116 | viability after 9 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 5.025855810871022 | [9] | [67,101] | 9 | hSpCas9 | negative selection | 1934670 | 112279290 | 112279313 | 12 | - | 26627737 | HCT116 | viability after 12 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | 0.7579045524593994 | [97] | [23,135,107] | 6 | hSpCas9 | negative selection | 2016980 | 112283156 | 112283179 | 12 | + | 26627737 | HCT116 | viability after 12 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | -1.2920769088699435 | [84] | [9,40,4] | -8 | hSpCas9 | negative selection | 2016981 | 112306175 | 112306198 | 12 | + | 26627737 | HCT116 | viability after 12 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | 0.2935780518164177 | [108] | [73,57,77] | 3 | hSpCas9 | negative selection | 2016982 | 112308816 | 112308839 | 12 | - | 26627737 | HCT116 | viability after 12 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | -0.7519279039207204 | [542] | [102,202,208] | -7 | hSpCas9 | negative selection | 2016983 | 112314461 | 112314484 | 12 | + | 26627737 | HCT116 | viability after 12 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 0.33255213650402593 | [135] | [30,164,80] | 3 | hSpCas9 | negative selection | 2016984 | 112319336 | 112319359 | 12 | + | 26627737 | HCT116 | viability after 12 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 1.1085978088024633 | [44] | [49,47,54] | 8 | hSpCas9 | negative selection | 2016985 | 112279290 | 112279313 | 12 | - | 26627737 | HCT116 | viability after 15 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | 0.8829100898732297 | [97] | [81,146,79] | 7 | hSpCas9 | negative selection | 2099295 | 112283156 | 112283179 | 12 | + | 26627737 | HCT116 | viability after 15 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | 0.2626839541314645 | [84] | [40,27,103] | 2 | hSpCas9 | negative selection | 2099296 | 112306175 | 112306198 | 12 | + | 26627737 | HCT116 | viability after 15 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | 0.6104309065387369 | [108] | [46,154,78] | 5 | hSpCas9 | negative selection | 2099297 | 112308816 | 112308839 | 12 | - | 26627737 | HCT116 | viability after 15 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | -1.292070262585208 | [542] | [118,132,128] | -8 | hSpCas9 | negative selection | 2099298 | 112314461 | 112314484 | 12 | + | 26627737 | HCT116 | viability after 15 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 0.9719539586191996 | [135] | [180,129,151] | 7 | hSpCas9 | negative selection | 2099299 | 112319336 | 112319359 | 12 | + | 26627737 | HCT116 | viability after 15 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 0.9393631137912297 | [44] | [73,56,20] | 7 | hSpCas9 | negative selection | 2099300 | 112279290 | 112279313 | 12 | - | 26627737 | HCT116 | viability after 18 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -0.14336961713829144 | [97] | [0,65,60] | -1 | hSpCas9 | negative selection | 2181610 | 112283156 | 112283179 | 12 | + | 26627737 | HCT116 | viability after 18 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | -0.15982960615137287 | [84] | [5,60,41] | -1 | hSpCas9 | negative selection | 2181611 | 112306175 | 112306198 | 12 | + | 26627737 | HCT116 | viability after 18 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | 0.7082569445348275 | [108] | [85,139,25] | 6 | hSpCas9 | negative selection | 2181612 | 112308816 | 112308839 | 12 | - | 26627737 | HCT116 | viability after 18 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | -1.7667495447927954 | [542] | [76,20,139] | -8 | hSpCas9 | negative selection | 2181613 | 112314461 | 112314484 | 12 | + | 26627737 | HCT116 | viability after 18 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 0.44666551302208335 | [135] | [83,98,84] | 4 | hSpCas9 | negative selection | 2181614 | 112319336 | 112319359 | 12 | + | 26627737 | HCT116 | viability after 18 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 0.8636283873206516 | [44] | [19,36,62] | 7 | hSpCas9 | negative selection | 2181615 | 112282340 | 112282363 | 12 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GCCACTGCACTCCAGCCTGGAAG | HECTD4 | ENSG00000173064 | 1.049956001898007 | [3,11] | [2,3] | 4 | dCas9-VP64 | positive selection | 2389027 | 112382241 | 112382264 | 12 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CACGGGCGAGGCAGCAAGTGGGG | HECTD4 | ENSG00000173064 | 1.4047208116236607 | [66,54] | [9,62] | 5 | dCas9-VP64 | positive selection | 2396756 | 112382191 | 112382214 | 12 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CCGCCGCGATCACCAGTCCATGG | HECTD4 | ENSG00000173064 | 1.8294706452594336 | [364,502] | [48,655] | 6 | dCas9-VP64 | positive selection | 2396757 | 112382269 | 112382292 | 12 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GCGACTCGGACCGCCTAGGGCGG | HECTD4 | ENSG00000173064 | -1.5571070139261143 | [2,104] | [1,5] | -8 | dCas9-VP64 | positive selection | 2396758 | 112204165 | 112204188 | 12 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GCCTGTAATCCCAGCTACTCTAG | HECTD4 | ENSG00000173064 | 0.6144504952986227 | [257,736] | [72,271] | 2 | dCas9-VP64 | positive selection | 2402963 | 112233331 | 112233354 | 12 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TCCCACCTCAGCCTCCCAAACAG | HECTD4 | ENSG00000173064 | -0.684504052123245 | [138,151] | [23,13] | -3 | dCas9-VP64 | positive selection | 2425565 | 112197187 | 112197210 | 12 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAGGCGTGAGCCACTGCGCCTGG | HECTD4 | ENSG00000173064 | -0.04533809600197003 | [16,0] | [1,0] | 0 | dCas9-VP64 | positive selection | 2431262 | 112359141 | 112359164 | 12 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TTGCCCAGGCTGGAGTGCAGGAG | HECTD4 | ENSG00000173064 | 0.9977856233970179 | [9,4] | [4,0] | 4 | dCas9-VP64 | positive selection | 2435919 | 112200195 | 112200218 | 12 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TGTGCCACTGCACTCCAACCCGG | HECTD4 | ENSG00000173064 | -0.3603328806955275 | [13,219] | [8,31] | -2 | dCas9-VP64 | positive selection | 2442219 | 112334114 | 112334137 | 12 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAGGAGAATCGCTTGAATCCTGG | HECTD4 | ENSG00000173064 | 1.579452491414227 | [20,39] | [3,36] | 6 | dCas9-VP64 | positive selection | 2477213 | 112320556 | 112320579 | 12 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CAGGCGTGGGCCACCACGCCTGG | HECTD4 | ENSG00000173064 | 2.170805682876019 | [0,2] | [0,2] | 7 | dCas9-VP64 | positive selection | 2477283 | 112282340 | 112282363 | 12 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GCCACTGCACTCCAGCCTGGAAG | HECTD4 | ENSG00000173064 | 0.3100958641524221 | [17,26] | [5,11] | 2 | dCas9-VP64 | positive selection | 2484282 | 112382241 | 112382264 | 12 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CACGGGCGAGGCAGCAAGTGGGG | HECTD4 | ENSG00000173064 | -0.6945631075510825 | [90,120] | [14,26] | -6 | dCas9-VP64 | positive selection | 2492011 | 112382191 | 112382214 | 12 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CCGCCGCGATCACCAGTCCATGG | HECTD4 | ENSG00000173064 | -0.4208927096882289 | [295,452] | [84,95] | -4 | dCas9-VP64 | positive selection | 2492012 | 112382269 | 112382292 | 12 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GCGACTCGGACCGCCTAGGGCGG | HECTD4 | ENSG00000173064 | 1.2179627986478545 | [46,8] | [35,7] | 7 | dCas9-VP64 | positive selection | 2492013 | 112204165 | 112204188 | 12 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GCCTGTAATCCCAGCTACTCTAG | HECTD4 | ENSG00000173064 | -0.8366236314632496 | [608,382] | [126,56] | -7 | dCas9-VP64 | positive selection | 2498218 | 112233331 | 112233354 | 12 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TCCCACCTCAGCCTCCCAAACAG | HECTD4 | ENSG00000173064 | 0.29312304600633954 | [90,145] | [39,52] | 2 | dCas9-VP64 | positive selection | 2520820 | 112197187 | 112197210 | 12 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAGGCGTGAGCCACTGCGCCTGG | HECTD4 | ENSG00000173064 | -1.0099528387584376 | [28,142] | [9,15] | -8 | dCas9-VP64 | positive selection | 2526517 | 112359141 | 112359164 | 12 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TTGCCCAGGCTGGAGTGCAGGAG | HECTD4 | ENSG00000173064 | -0.1814090993543942 | [50,40] | [18,6] | -2 | dCas9-VP64 | positive selection | 2531174 | 112200195 | 112200218 | 12 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TGTGCCACTGCACTCCAACCCGG | HECTD4 | ENSG00000173064 | 2.8983611220710697 | [175,93] | [650,31] | 9 | dCas9-VP64 | positive selection | 2537474 | 112334114 | 112334137 | 12 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAGGAGAATCGCTTGAATCCTGG | HECTD4 | ENSG00000173064 | 0.3334805796334224 | [96,125] | [24,64] | 2 | dCas9-VP64 | positive selection | 2572468 | 112320556 | 112320579 | 12 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CAGGCGTGGGCCACCACGCCTGG | HECTD4 | ENSG00000173064 | -0.9433721542686317 | [3,48] | [3,3] | -8 | dCas9-VP64 | positive selection | 2572538 | 112381958 | 112381981 | 12 | + | 27661255 | K562 | viability | GTCGGTGTCCGCGGCCTCTGGGG | HECTD4 | ENSG00000173064 | 0.09089577298246132 | [998,930] | [821,821] | 3 | dCas9-KRAB | negative selection | 5484388 | 112381977 | 112382000 | 12 | + | 27661255 | K562 | viability | GGGGCCCCGAGGATCTCGCTGGG | HECTD4 | ENSG00000173064 | 0.26105598119776224 | [487,641] | [555,522] | 8 | dCas9-KRAB | negative selection | 5484389 | 112382008 | 112382031 | 12 | - | 27661255 | K562 | viability | GCTGATCCGGGTCACCGACCTGG | HECTD4 | ENSG00000173064 | 0.0493351484200093 | [278,347] | [330,195] | 1 | dCas9-KRAB | negative selection | 5484390 | 112382353 | 112382376 | 12 | - | 27661255 | K562 | viability | GATCCTGCTCCTGAGGGCGGCGG | HECTD4 | ENSG00000173064 | -0.0339211233458479 | [523,649] | [486,429] | -1 | dCas9-KRAB | negative selection | 5484391 | 112382359 | 112382382 | 12 | - | 27661255 | K562 | viability | GAGGCGGATCCTGCTCCTGAGGG | HECTD4 | ENSG00000173064 | -0.09030550198020748 | [1349,1296] | [1077,921] | -3 | dCas9-KRAB | negative selection | 5484392 | 112279290 | 112279313 | 12 | - | 27869803 | HPAFII | viability after 27 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -1.7907694616231555 | [139] | [35,8,NaN] | -8 | hSpCas9 | negative selection | 9545255 | 112283156 | 112283179 | 12 | + | 27869803 | HPAFII | viability after 27 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | 0.9917107917954191 | [37] | [48,31,NaN] | 7 | hSpCas9 | negative selection | 9545256 | 112306175 | 112306198 | 12 | + | 27869803 | HPAFII | viability after 27 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | -1.088442807754457 | [106] | [56,0,NaN] | -6 | hSpCas9 | negative selection | 9545257 | 112308816 | 112308839 | 12 | - | 27869803 | HPAFII | viability after 27 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 0.6050719148855047 | [225] | [201,162,NaN] | 5 | hSpCas9 | negative selection | 9545258 | 112314461 | 112314484 | 12 | + | 27869803 | HPAFII | viability after 27 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 0.08285867985361461 | [167] | [44,133,NaN] | 0 | hSpCas9 | negative selection | 9545259 | 112319336 | 112319359 | 12 | + | 27869803 | HPAFII | viability after 27 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | -0.5469580566518024 | [47] | [31,4,NaN] | -4 | hSpCas9 | negative selection | 9545260 | 112279290 | 112279313 | 12 | - | 27869803 | HPAFII | viability after 15 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -0.877945119778833 | [139] | [145,41,NaN] | -7 | hSpCas9 | negative selection | 9627704 | 112283156 | 112283179 | 12 | + | 27869803 | HPAFII | viability after 15 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | 1.3110967537028386 | [37] | [125,85,NaN] | 9 | hSpCas9 | negative selection | 9627705 | 112306175 | 112306198 | 12 | + | 27869803 | HPAFII | viability after 15 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | -0.77062844559284 | [106] | [133,25,NaN] | -7 | hSpCas9 | negative selection | 9627706 | 112308816 | 112308839 | 12 | - | 27869803 | HPAFII | viability after 15 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 0.8634897833129009 | [225] | [481,416,NaN] | 8 | hSpCas9 | negative selection | 9627707 | 112314461 | 112314484 | 12 | + | 27869803 | HPAFII | viability after 15 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 0.1035948577739787 | [167] | [156,216,NaN] | 1 | hSpCas9 | negative selection | 9627708 | 112319336 | 112319359 | 12 | + | 27869803 | HPAFII | viability after 15 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | -0.8110538238523808 | [47] | [58,10,NaN] | -7 | hSpCas9 | negative selection | 9627709 | 112279290 | 112279313 | 12 | - | 27869803 | ASPC1 | viability after 36 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -4.149613607224633 | [368] | [4,11,4] | -9 | hSpCas9 | negative selection | 9710153 | 112283156 | 112283179 | 12 | + | 27869803 | ASPC1 | viability after 36 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | -0.16146963660304303 | [141] | [27,50,49] | -2 | hSpCas9 | negative selection | 9710154 | 112306175 | 112306198 | 12 | + | 27869803 | ASPC1 | viability after 36 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | 0.5829108286494159 | [255] | [198,96,115] | 6 | hSpCas9 | negative selection | 9710155 | 112308816 | 112308839 | 12 | - | 27869803 | ASPC1 | viability after 36 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 0.7166604545551405 | [837] | [895,591,95] | 7 | hSpCas9 | negative selection | 9710156 | 112314461 | 112314484 | 12 | + | 27869803 | ASPC1 | viability after 36 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 0.5582316467021384 | [402] | [596,48,56] | 5 | hSpCas9 | negative selection | 9710157 | 112319336 | 112319359 | 12 | + | 27869803 | ASPC1 | viability after 36 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 0.4161226683095196 | [162] | [56,20,131] | 4 | hSpCas9 | negative selection | 9710158 | 112279290 | 112279313 | 12 | - | 27869803 | PATU8988S | viability after 35 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -0.7575431672970301 | [255] | [54,66,NaN] | -6 | hSpCas9 | negative selection | 9792602 | 112283156 | 112283179 | 12 | + | 27869803 | PATU8988S | viability after 35 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | -0.48178805864259955 | [181] | [47,56,NaN] | -5 | hSpCas9 | negative selection | 9792603 | 112306175 | 112306198 | 12 | + | 27869803 | PATU8988S | viability after 35 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | -0.09078635477586294 | [249] | [114,73,NaN] | -1 | hSpCas9 | negative selection | 9792604 | 112308816 | 112308839 | 12 | - | 27869803 | PATU8988S | viability after 35 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | -0.037550692771739946 | [762] | [256,341,NaN] | 0 | hSpCas9 | negative selection | 9792605 | 112314461 | 112314484 | 12 | + | 27869803 | PATU8988S | viability after 35 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | -0.3971495629036961 | [226] | [35,102,NaN] | -4 | hSpCas9 | negative selection | 9792606 | 112319336 | 112319359 | 12 | + | 27869803 | PATU8988S | viability after 35 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | 0.1426717573081855 | [171] | [64,87,NaN] | 1 | hSpCas9 | negative selection | 9792607 | 112279290 | 112279313 | 12 | - | 27869803 | PATU8988S | viability after 31 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -0.49721546415645923 | [255] | [70,73,NaN] | -5 | hSpCas9 | negative selection | 9875051 | 112283156 | 112283179 | 12 | + | 27869803 | PATU8988S | viability after 31 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | -0.37707201661092826 | [181] | [54,56,NaN] | -4 | hSpCas9 | negative selection | 9875052 | 112306175 | 112306198 | 12 | + | 27869803 | PATU8988S | viability after 31 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | 0.49570284964541134 | [249] | [129,153,NaN] | 6 | hSpCas9 | negative selection | 9875053 | 112308816 | 112308839 | 12 | - | 27869803 | PATU8988S | viability after 31 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | -0.3193808779863808 | [762] | [161,347,NaN] | -4 | hSpCas9 | negative selection | 9875054 | 112314461 | 112314484 | 12 | + | 27869803 | PATU8988S | viability after 31 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | -0.8007114761367569 | [226] | [58,42,NaN] | -7 | hSpCas9 | negative selection | 9875055 | 112319336 | 112319359 | 12 | + | 27869803 | PATU8988S | viability after 31 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | -0.0828250824952379 | [171] | [51,80,NaN] | -1 | hSpCas9 | negative selection | 9875056 | 112279290 | 112279313 | 12 | - | 27869803 | HPAFII | viability after 35 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -3.1898744414966327 | [139] | [11,2,NaN] | -8 | hSpCas9 | negative selection | 9957500 | 112283156 | 112283179 | 12 | + | 27869803 | HPAFII | viability after 35 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | 0.6610605486288215 | [37] | [44,13,NaN] | 4 | hSpCas9 | negative selection | 9957501 | 112306175 | 112306198 | 12 | + | 27869803 | HPAFII | viability after 35 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | -1.395027468667233 | [106] | [37,0,NaN] | -6 | hSpCas9 | negative selection | 9957502 | 112308816 | 112308839 | 12 | - | 27869803 | HPAFII | viability after 35 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 1.2490159908069403 | [225] | [135,424,NaN] | 8 | hSpCas9 | negative selection | 9957503 | 112314461 | 112314484 | 12 | + | 27869803 | HPAFII | viability after 35 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 0.6885522328299938 | [167] | [42,242,NaN] | 4 | hSpCas9 | negative selection | 9957504 | 112319336 | 112319359 | 12 | + | 27869803 | HPAFII | viability after 35 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | -1.3588533287696585 | [47] | [16,0,NaN] | -6 | hSpCas9 | negative selection | 9957505 | 112279290 | 112279313 | 12 | - | 27869803 | HPAFII | viability after 31 days | ATGCTGGTGCCTCCTCCAGGGGG | HECTD4 | ENSG00000173064 | -2.8364801986324117 | [139] | [10,10,NaN] | -8 | hSpCas9 | negative selection | 10039949 | 112283156 | 112283179 | 12 | + | 27869803 | HPAFII | viability after 31 days | GGCAGCAAGCGTTGCTGACGGGG | HECTD4 | ENSG00000173064 | 1.2840987494316947 | [37] | [83,16,NaN] | 8 | hSpCas9 | negative selection | 10039950 | 112306175 | 112306198 | 12 | + | 27869803 | HPAFII | viability after 31 days | AGTGCTCATGGTGCTGCCAATGG | HECTD4 | ENSG00000173064 | -1.2954905309356042 | [106] | [45,0,NaN] | -7 | hSpCas9 | negative selection | 10039951 | 112308816 | 112308839 | 12 | - | 27869803 | HPAFII | viability after 31 days | GCAGCGGCAGTCTTCTCCACCGG | HECTD4 | ENSG00000173064 | 0.7964243651175001 | [225] | [181,261,NaN] | 6 | hSpCas9 | negative selection | 10039952 | 112314461 | 112314484 | 12 | + | 27869803 | HPAFII | viability after 31 days | ATAGCACATCAGCTACAGGCAGG | HECTD4 | ENSG00000173064 | 0.7073048954138342 | [167] | [40,276,NaN] | 5 | hSpCas9 | negative selection | 10039953 | 112319336 | 112319359 | 12 | + | 27869803 | HPAFII | viability after 31 days | ATTCCATTGAGACAGTCAGCAGG | HECTD4 | ENSG00000173064 | -0.9898501278413678 | [47] | [14,11,NaN] | -6 | hSpCas9 | negative selection | 10039954 | 112210171 | 112210194 | 12 | + | 28162770 | P31FUJ | viability | ACAGGTCAGCAGCATTGCGGTGG | HECTD4 | ENSG00000173064 | 0.08834372995456352 | [2213] | [2765] | 0 | hSpCas9 | negative selection | 10168186 | 112283159 | 112283182 | 12 | + | 28162770 | P31FUJ | viability | AGCAAGCGTTGCTGACGGGGAGG | HECTD4 | ENSG00000173064 | 0.0726674677398117 | [334] | [413] | 0 | hSpCas9 | negative selection | 10168187 | 112190874 | 112190897 | 12 | + | 28162770 | P31FUJ | viability | GGACAGCAGCTGCTCTGCGAAGG | HECTD4 | ENSG00000173064 | -1.326134780751682 | [2154] | [1009] | -7 | hSpCas9 | negative selection | 10168188 | 112184882 | 112184905 | 12 | + | 28162770 | P31FUJ | viability | TGAGCAGGGTGAGTGCGCGGTGG | HECTD4 | ENSG00000173064 | -0.018078749705084718 | [996] | [1156] | 0 | hSpCas9 | negative selection | 10168189 | 112184689 | 112184712 | 12 | - | 28162770 | P31FUJ | viability | AAGGCCTGCAACGCCCACGGCGG | HECTD4 | ENSG00000173064 | 0.21705427213790918 | [961] | [1313] | 2 | hSpCas9 | negative selection | 10168190 | 112179228 | 112179251 | 12 | + | 28162770 | P31FUJ | viability | GAGGTGGAGGAGGTTGCCTGGGG | HECTD4 | ENSG00000173064 | -0.8205471458068616 | [1556] | [1035] | -6 | hSpCas9 | negative selection | 10168191 | 112167496 | 112167519 | 12 | - | 28162770 | P31FUJ | viability | GAGCCCCATCACCTACGGGGAGG | HECTD4 | ENSG00000173064 | -1.348928261530832 | [1111] | [512] | -7 | hSpCas9 | negative selection | 10168192 | 112319414 | 112319437 | 12 | + | 28162770 | P31FUJ | viability | GCAGTTATGTTACAGAGAGAGGG | HECTD4 | ENSG00000173064 | 0.3281197088645953 | [826] | [1219] | 3 | hSpCas9 | negative selection | 10168193 | 112308800 | 112308823 | 12 | + | 28162770 | P31FUJ | viability | TATCGAAAGAGACAGGCCGGTGG | HECTD4 | ENSG00000173064 | 0.2650773815961447 | [790] | [1116] | 3 | hSpCas9 | negative selection | 10168194 | 112306180 | 112306203 | 12 | + | 28162770 | P31FUJ | viability | TCATGGTGCTGCCAATGGGGAGG | HECTD4 | ENSG00000173064 | 0.5734954108601831 | [974] | [1704] | 6 | hSpCas9 | negative selection | 10168195 | 112210171 | 112210194 | 12 | + | 28162770 | TF1 | viability | ACAGGTCAGCAGCATTGCGGTGG | HECTD4 | ENSG00000173064 | NaN | [NaN] | [284] | 1 | hSpCas9 | negative selection | 10337552 | 112283159 | 112283182 | 12 | + | 28162770 | TF1 | viability | AGCAAGCGTTGCTGACGGGGAGG | HECTD4 | ENSG00000173064 | NaN | [NaN] | [16] | 1 | hSpCas9 | negative selection | 10337553 | 112190874 | 112190897 | 12 | + | 28162770 | TF1 | viability | GGACAGCAGCTGCTCTGCGAAGG | HECTD4 | ENSG00000173064 | NaN | [NaN] | [72] | 1 | hSpCas9 | negative selection | 10337554 | 112184882 | 112184905 | 12 | + | 28162770 | TF1 | viability | TGAGCAGGGTGAGTGCGCGGTGG | HECTD4 | ENSG00000173064 | NaN | [NaN] | [213] | 1 | hSpCas9 | negative selection | 10337555 | 112184689 | 112184712 | 12 | - | 28162770 | TF1 | viability | AAGGCCTGCAACGCCCACGGCGG | HECTD4 | ENSG00000173064 | NaN | [NaN] | [128] | 1 | hSpCas9 | negative selection | 10337556 | 112179228 | 112179251 | 12 | + | 28162770 | TF1 | viability | GAGGTGGAGGAGGTTGCCTGGGG | HECTD4 | ENSG00000173064 | NaN | [NaN] | [104] | 1 | hSpCas9 | negative selection | 10337557 | 112167496 | 112167519 | 12 | - | 28162770 | TF1 | viability | GAGCCCCATCACCTACGGGGAGG | HECTD4 | ENSG00000173064 | NaN | [NaN] | [124] | 1 | hSpCas9 | negative selection | 10337558 | 112319414 | 112319437 | 12 | + | 28162770 | TF1 | viability | GCAGTTATGTTACAGAGAGAGGG | HECTD4 | ENSG00000173064 | NaN | [NaN] | [64] | 1 | hSpCas9 | negative selection | 10337559 | 112308800 | 112308823 | 12 | + | 28162770 | TF1 | viability | TATCGAAAGAGACAGGCCGGTGG | HECTD4 | ENSG00000173064 | NaN | [NaN] | [58] | 1 | hSpCas9 | negative selection | 10337560 | 112306180 | 112306203 | 12 | + | 28162770 | TF1 | viability | TCATGGTGCTGCCAATGGGGAGG | HECTD4 | ENSG00000173064 | NaN | [NaN] | [202] | 1 | hSpCas9 | negative selection | 10337561 | 112210171 | 112210194 | 12 | + | 28162770 | SKM1 | viability | ACAGGTCAGCAGCATTGCGGTGG | HECTD4 | ENSG00000173064 | 0.14710429403221092 | [117] | [230] | 1 | hSpCas9 | negative selection | 10506918 | 112283159 | 112283182 | 12 | + | 28162770 | SKM1 | viability | AGCAAGCGTTGCTGACGGGGAGG | HECTD4 | ENSG00000173064 | -0.18457177740671393 | [17] | [27] | -1 | hSpCas9 | negative selection | 10506919 | 112190874 | 112190897 | 12 | + | 28162770 | SKM1 | viability | GGACAGCAGCTGCTCTGCGAAGG | HECTD4 | ENSG00000173064 | -0.323012420410702 | [120] | [170] | -3 | hSpCas9 | negative selection | 10506920 | 112184882 | 112184905 | 12 | + | 28162770 | SKM1 | viability | TGAGCAGGGTGAGTGCGCGGTGG | HECTD4 | ENSG00000173064 | -0.4809647801869385 | [74] | [94] | -4 | hSpCas9 | negative selection | 10506921 | 112184689 | 112184712 | 12 | - | 28162770 | SKM1 | viability | AAGGCCTGCAACGCCCACGGCGG | HECTD4 | ENSG00000173064 | 0.5860830406150714 | [51] | [137] | 5 | hSpCas9 | negative selection | 10506922 | 112179228 | 112179251 | 12 | + | 28162770 | SKM1 | viability | GAGGTGGAGGAGGTTGCCTGGGG | HECTD4 | ENSG00000173064 | 0.16582358803189212 | [118] | [235] | 1 | hSpCas9 | negative selection | 10506923 | 112167496 | 112167519 | 12 | - | 28162770 | SKM1 | viability | GAGCCCCATCACCTACGGGGAGG | HECTD4 | ENSG00000173064 | -0.5000736031346432 | [51] | [64] | -4 | hSpCas9 | negative selection | 10506924 | 112319414 | 112319437 | 12 | + | 28162770 | SKM1 | viability | GCAGTTATGTTACAGAGAGAGGG | HECTD4 | ENSG00000173064 | 0.1440509700546568 | [42] | [83] | 1 | hSpCas9 | negative selection | 10506925 | 112308800 | 112308823 | 12 | + | 28162770 | SKM1 | viability | TATCGAAAGAGACAGGCCGGTGG | HECTD4 | ENSG00000173064 | 0.06478769153000363 | [52] | [97] | 0 | hSpCas9 | negative selection | 10506926 | 112306180 | 112306203 | 12 | + | 28162770 | SKM1 | viability | TCATGGTGCTGCCAATGGGGAGG | HECTD4 | ENSG00000173064 | 0.26763551446267086 | [77] | [165] | 2 | hSpCas9 | negative selection | 10506927 | 112210171 | 112210194 | 12 | + | 28162770 | SKM1 | viability | ACAGGTCAGCAGCATTGCGGTGG | HECTD4 | ENSG00000173064 | 0.14710429403221092 | [117] | [230] | 1 | hSpCas9 | negative selection | 10676284 | 112283159 | 112283182 | 12 | + | 28162770 | SKM1 | viability | AGCAAGCGTTGCTGACGGGGAGG | HECTD4 | ENSG00000173064 | -0.18457177740671393 | [17] | [27] | -1 | hSpCas9 | negative selection | 10676285 | 112190874 | 112190897 | 12 | + | 28162770 | SKM1 | viability | GGACAGCAGCTGCTCTGCGAAGG | HECTD4 | ENSG00000173064 | -0.323012420410702 | [120] | [170] | -3 | hSpCas9 | negative selection | 10676286 | 112184882 | 112184905 | 12 | + | 28162770 | SKM1 | viability | TGAGCAGGGTGAGTGCGCGGTGG | HECTD4 | ENSG00000173064 | -0.4809647801869385 | [74] | [94] | -4 | hSpCas9 | negative selection | 10676287 | 112184689 | 112184712 | 12 | - | 28162770 | SKM1 | viability | AAGGCCTGCAACGCCCACGGCGG | HECTD4 | ENSG00000173064 | 0.5860830406150714 | [51] | [137] | 5 | hSpCas9 | negative selection | 10676288 | 112179228 | 112179251 | 12 | + | 28162770 | SKM1 | viability | GAGGTGGAGGAGGTTGCCTGGGG | HECTD4 | ENSG00000173064 | 0.16582358803189212 | [118] | [235] | 1 | hSpCas9 | negative selection | 10676289 | 112167496 | 112167519 | 12 | - | 28162770 | SKM1 | viability | GAGCCCCATCACCTACGGGGAGG | HECTD4 | ENSG00000173064 | -0.5000736031346432 | [51] | [64] | -4 | hSpCas9 | negative selection | 10676290 | 112319414 | 112319437 | 12 | + | 28162770 | SKM1 | viability | GCAGTTATGTTACAGAGAGAGGG | HECTD4 | ENSG00000173064 | 0.1440509700546568 | [42] | [83] | 1 | hSpCas9 | negative selection | 10676291 | 112308800 | 112308823 | 12 | + | 28162770 | SKM1 | viability | TATCGAAAGAGACAGGCCGGTGG | HECTD4 | ENSG00000173064 | 0.06478769153000363 | [52] | [97] | 0 | hSpCas9 | negative selection | 10676292 | 112306180 | 112306203 | 12 | + | 28162770 | SKM1 | viability | TCATGGTGCTGCCAATGGGGAGG | HECTD4 | ENSG00000173064 | 0.26763551446267086 | [77] | [165] | 2 | hSpCas9 | negative selection | 10676293 | 112210171 | 112210194 | 12 | + | 28162770 | PL21 | viability | ACAGGTCAGCAGCATTGCGGTGG | HECTD4 | ENSG00000173064 | 0.5455266822006715 | [487] | [309] | 5 | hSpCas9 | negative selection | 10845650 | 112283159 | 112283182 | 12 | + | 28162770 | PL21 | viability | AGCAAGCGTTGCTGACGGGGAGG | HECTD4 | ENSG00000173064 | 1.1626649090706573 | [77] | [75] | 8 | hSpCas9 | negative selection | 10845651 | 112190874 | 112190897 | 12 | + | 28162770 | PL21 | viability | GGACAGCAGCTGCTCTGCGAAGG | HECTD4 | ENSG00000173064 | -0.6852178195695572 | [531] | [143] | -5 | hSpCas9 | negative selection | 10845652 | 112184882 | 112184905 | 12 | + | 28162770 | PL21 | viability | TGAGCAGGGTGAGTGCGCGGTGG | HECTD4 | ENSG00000173064 | -1.7571559345564416 | [232] | [29] | -8 | hSpCas9 | negative selection | 10845653 | 112184689 | 112184712 | 12 | - | 28162770 | PL21 | viability | AAGGCCTGCAACGCCCACGGCGG | HECTD4 | ENSG00000173064 | -0.4155196834547523 | [189] | [61] | -3 | hSpCas9 | negative selection | 10845654 | 112179228 | 112179251 | 12 | + | 28162770 | PL21 | viability | GAGGTGGAGGAGGTTGCCTGGGG | HECTD4 | ENSG00000173064 | 0.30477315567991337 | [451] | [242] | 2 | hSpCas9 | negative selection | 10845655 | 112167496 | 112167519 | 12 | - | 28162770 | PL21 | viability | GAGCCCCATCACCTACGGGGAGG | HECTD4 | ENSG00000173064 | -1.5924183056402035 | [290] | [41] | -7 | hSpCas9 | negative selection | 10845656 | 112319414 | 112319437 | 12 | + | 28162770 | PL21 | viability | GCAGTTATGTTACAGAGAGAGGG | HECTD4 | ENSG00000173064 | -0.4765654548594117 | [210] | [65] | -3 | hSpCas9 | negative selection | 10845657 | 112308800 | 112308823 | 12 | + | 28162770 | PL21 | viability | TATCGAAAGAGACAGGCCGGTGG | HECTD4 | ENSG00000173064 | 0.4902676812053891 | [210] | [128] | 4 | hSpCas9 | negative selection | 10845658 | 112306180 | 112306203 | 12 | + | 28162770 | PL21 | viability | TCATGGTGCTGCCAATGGGGAGG | HECTD4 | ENSG00000173064 | 0.7289590371729426 | [261] | [188] | 6 | hSpCas9 | negative selection | 10845659 | 112210171 | 112210194 | 12 | + | 28162770 | P31FUJ | viability | ACAGGTCAGCAGCATTGCGGTGG | HECTD4 | ENSG00000173064 | 0.08834372995456352 | [2213] | [2765] | 0 | hSpCas9 | negative selection | 11015016 | 112283159 | 112283182 | 12 | + | 28162770 | P31FUJ | viability | AGCAAGCGTTGCTGACGGGGAGG | HECTD4 | ENSG00000173064 | 0.0726674677398117 | [334] | [413] | 0 | hSpCas9 | negative selection | 11015017 | 112190874 | 112190897 | 12 | + | 28162770 | P31FUJ | viability | GGACAGCAGCTGCTCTGCGAAGG | HECTD4 | ENSG00000173064 | -1.326134780751682 | [2154] | [1009] | -7 | hSpCas9 | negative selection | 11015018 | 112184882 | 112184905 | 12 | + | 28162770 | P31FUJ | viability | TGAGCAGGGTGAGTGCGCGGTGG | HECTD4 | ENSG00000173064 | -0.018078749705084718 | [996] | [1156] | 0 | hSpCas9 | negative selection | 11015019 | 112184689 | 112184712 | 12 | - | 28162770 | P31FUJ | viability | AAGGCCTGCAACGCCCACGGCGG | HECTD4 | ENSG00000173064 | 0.21705427213790918 | [961] | [1313] | 2 | hSpCas9 | negative selection | 11015020 | 112179228 | 112179251 | 12 | + | 28162770 | P31FUJ | viability | GAGGTGGAGGAGGTTGCCTGGGG | HECTD4 | ENSG00000173064 | -0.8205471458068616 | [1556] | [1035] | -6 | hSpCas9 | negative selection | 11015021 | 112167496 | 112167519 | 12 | - | 28162770 | P31FUJ | viability | GAGCCCCATCACCTACGGGGAGG | HECTD4 | ENSG00000173064 | -1.348928261530832 | [1111] | [512] | -7 | hSpCas9 | negative selection | 11015022 | 112319414 | 112319437 | 12 | + | 28162770 | P31FUJ | viability | GCAGTTATGTTACAGAGAGAGGG | HECTD4 | ENSG00000173064 | 0.3281197088645953 | [826] | [1219] | 3 | hSpCas9 | negative selection | 11015023 | 112308800 | 112308823 | 12 | + | 28162770 | P31FUJ | viability | TATCGAAAGAGACAGGCCGGTGG | HECTD4 | ENSG00000173064 | 0.2650773815961447 | [790] | [1116] | 3 | hSpCas9 | negative selection | 11015024 | 112306180 | 112306203 | 12 | + | 28162770 | P31FUJ | viability | TCATGGTGCTGCCAATGGGGAGG | HECTD4 | ENSG00000173064 | 0.5734954108601831 | [974] | [1704] | 6 | hSpCas9 | negative selection | 11015025 | 112210171 | 112210194 | 12 | + | 28162770 | OCIAML5 | viability | ACAGGTCAGCAGCATTGCGGTGG | HECTD4 | ENSG00000173064 | 0.14793342913600305 | [237] | [475] | 1 | hSpCas9 | negative selection | 11184382 | 112283159 | 112283182 | 12 | + | 28162770 | OCIAML5 | viability | AGCAAGCGTTGCTGACGGGGAGG | HECTD4 | ENSG00000173064 | 0.28223452084759404 | [40] | [89] | 2 | hSpCas9 | negative selection | 11184383 | 112190874 | 112190897 | 12 | + | 28162770 | OCIAML5 | viability | GGACAGCAGCTGCTCTGCGAAGG | HECTD4 | ENSG00000173064 | -0.9194420062055273 | [262] | [250] | -5 | hSpCas9 | negative selection | 11184384 | 112184882 | 112184905 | 12 | + | 28162770 | OCIAML5 | viability | TGAGCAGGGTGAGTGCGCGGTGG | HECTD4 | ENSG00000173064 | -0.2009137904483742 | [141] | [222] | -1 | hSpCas9 | negative selection | 11184385 | 112184689 | 112184712 | 12 | - | 28162770 | OCIAML5 | viability | AAGGCCTGCAACGCCCACGGCGG | HECTD4 | ENSG00000173064 | -0.12459242567508835 | [121] | [201] | -1 | hSpCas9 | negative selection | 11184386 | 112179228 | 112179251 | 12 | + | 28162770 | OCIAML5 | viability | GAGGTGGAGGAGGTTGCCTGGGG | HECTD4 | ENSG00000173064 | -0.2690844342710814 | [242] | [363] | -2 | hSpCas9 | negative selection | 11184387 | 112167496 | 112167519 | 12 | - | 28162770 | OCIAML5 | viability | GAGCCCCATCACCTACGGGGAGG | HECTD4 | ENSG00000173064 | -1.068490034406201 | [200] | [172] | -6 | hSpCas9 | negative selection | 11184388 | 112319414 | 112319437 | 12 | + | 28162770 | OCIAML5 | viability | GCAGTTATGTTACAGAGAGAGGG | HECTD4 | ENSG00000173064 | -0.09822715813339483 | [152] | [257] | 0 | hSpCas9 | negative selection | 11184389 | 112308800 | 112308823 | 12 | + | 28162770 | OCIAML5 | viability | TATCGAAAGAGACAGGCCGGTGG | HECTD4 | ENSG00000173064 | 0.011729045537691773 | [110] | [201] | 0 | hSpCas9 | negative selection | 11184390 | 112306180 | 112306203 | 12 | + | 28162770 | OCIAML5 | viability | TCATGGTGCTGCCAATGGGGAGG | HECTD4 | ENSG00000173064 | 0.1840026838435248 | [157] | [323] | 1 | hSpCas9 | negative selection | 11184391 | 112210171 | 112210194 | 12 | + | 28162770 | EOL1 | viability | ACAGGTCAGCAGCATTGCGGTGG | HECTD4 | ENSG00000173064 | 0.06867034188133858 | [770] | [425] | 0 | hSpCas9 | negative selection | 11353748 | 112283159 | 112283182 | 12 | + | 28162770 | EOL1 | viability | AGCAAGCGTTGCTGACGGGGAGG | HECTD4 | ENSG00000173064 | -0.2383907995556711 | [102] | [45] | -2 | hSpCas9 | negative selection | 11353749 | 112190874 | 112190897 | 12 | + | 28162770 | EOL1 | viability | GGACAGCAGCTGCTCTGCGAAGG | HECTD4 | ENSG00000173064 | -0.028403655625033997 | [723] | [373] | 0 | hSpCas9 | negative selection | 11353750 | 112184882 | 112184905 | 12 | + | 28162770 | EOL1 | viability | TGAGCAGGGTGAGTGCGCGGTGG | HECTD4 | ENSG00000173064 | 0.44941982245536133 | [334] | [240] | 4 | hSpCas9 | negative selection | 11353751 | 112184689 | 112184712 | 12 | - | 28162770 | EOL1 | viability | AAGGCCTGCAACGCCCACGGCGG | HECTD4 | ENSG00000173064 | -0.23877449504753062 | [326] | [145] | -2 | hSpCas9 | negative selection | 11353752 | 112179228 | 112179251 | 12 | + | 28162770 | EOL1 | viability | GAGGTGGAGGAGGTTGCCTGGGG | HECTD4 | ENSG00000173064 | -0.2684324660994435 | [614] | [268] | -2 | hSpCas9 | negative selection | 11353753 | 112167496 | 112167519 | 12 | - | 28162770 | EOL1 | viability | GAGCCCCATCACCTACGGGGAGG | HECTD4 | ENSG00000173064 | -1.060501886963494 | [383] | [96] | -6 | hSpCas9 | negative selection | 11353754 | 112319414 | 112319437 | 12 | + | 28162770 | EOL1 | viability | GCAGTTATGTTACAGAGAGAGGG | HECTD4 | ENSG00000173064 | -0.015580772452066682 | [235] | [122] | 0 | hSpCas9 | negative selection | 11353755 | 112308800 | 112308823 | 12 | + | 28162770 | EOL1 | viability | TATCGAAAGAGACAGGCCGGTGG | HECTD4 | ENSG00000173064 | -0.5499381927890522 | [288] | [103] | -4 | hSpCas9 | negative selection | 11353756 | 112306180 | 112306203 | 12 | + | 28162770 | EOL1 | viability | TCATGGTGCTGCCAATGGGGAGG | HECTD4 | ENSG00000173064 | 0.6873825912070466 | [408] | [346] | 6 | hSpCas9 | negative selection | 11353757 | 112210171 | 112210194 | 12 | + | 28162770 | MOLM13 | viability | ACAGGTCAGCAGCATTGCGGTGG | HECTD4 | ENSG00000173064 | 0.6261190493545166 | [577] | [644] | 5 | hSpCas9 | negative selection | 11523114 | 112283159 | 112283182 | 12 | + | 28162770 | MOLM13 | viability | AGCAAGCGTTGCTGACGGGGAGG | HECTD4 | ENSG00000173064 | 0.6719032735661721 | [78] | [90] | 5 | hSpCas9 | negative selection | 11523115 | 112190874 | 112190897 | 12 | + | 28162770 | MOLM13 | viability | GGACAGCAGCTGCTCTGCGAAGG | HECTD4 | ENSG00000173064 | -1.182011850876898 | [567] | [180] | -6 | hSpCas9 | negative selection | 11523116 | 112184882 | 112184905 | 12 | + | 28162770 | MOLM13 | viability | TGAGCAGGGTGAGTGCGCGGTGG | HECTD4 | ENSG00000173064 | -0.6907025290901464 | [316] | [141] | -4 | hSpCas9 | negative selection | 11523117 | 112184689 | 112184712 | 12 | - | 28162770 | MOLM13 | viability | AAGGCCTGCAACGCCCACGGCGG | HECTD4 | ENSG00000173064 | 0.5023777579298695 | [247] | [253] | 4 | hSpCas9 | negative selection | 11523118 | 112179228 | 112179251 | 12 | + | 28162770 | MOLM13 | viability | GAGGTGGAGGAGGTTGCCTGGGG | HECTD4 | ENSG00000173064 | -0.22460158348102255 | [542] | [335] | -1 | hSpCas9 | negative selection | 11523119 | 112167496 | 112167519 | 12 | - | 28162770 | MOLM13 | viability | GAGCCCCATCACCTACGGGGAGG | HECTD4 | ENSG00000173064 | -1.5862440555889 | [352] | [84] | -7 | hSpCas9 | negative selection | 11523120 | 112319414 | 112319437 | 12 | + | 28162770 | MOLM13 | viability | GCAGTTATGTTACAGAGAGAGGG | HECTD4 | ENSG00000173064 | 0.41916334172815756 | [270] | [261] | 3 | hSpCas9 | negative selection | 11523121 | 112308800 | 112308823 | 12 | + | 28162770 | MOLM13 | viability | TATCGAAAGAGACAGGCCGGTGG | HECTD4 | ENSG00000173064 | 0.5506896865970916 | [236] | [250] | 4 | hSpCas9 | negative selection | 11523122 | 112306180 | 112306203 | 12 | + | 28162770 | MOLM13 | viability | TCATGGTGCTGCCAATGGGGAGG | HECTD4 | ENSG00000173064 | 0.5030788100068788 | [323] | [331] | 4 | hSpCas9 | negative selection | 11523123 | 112210171 | 112210194 | 12 | + | 28162770 | HEL | viability | ACAGGTCAGCAGCATTGCGGTGG | HECTD4 | ENSG00000173064 | 0.4741845622914591 | [525] | [467] | 4 | hSpCas9 | negative selection | 11692480 | 112283159 | 112283182 | 12 | + | 28162770 | HEL | viability | AGCAAGCGTTGCTGACGGGGAGG | HECTD4 | ENSG00000173064 | 0.12594783392078024 | [92] | [64] | 1 | hSpCas9 | negative selection | 11692481 | 112190874 | 112190897 | 12 | + | 28162770 | HEL | viability | GGACAGCAGCTGCTCTGCGAAGG | HECTD4 | ENSG00000173064 | -1.1709243425254705 | [572] | [162] | -6 | hSpCas9 | negative selection | 11692482 | 112184882 | 112184905 | 12 | + | 28162770 | HEL | viability | TGAGCAGGGTGAGTGCGCGGTGG | HECTD4 | ENSG00000173064 | 0.07714165614613187 | [258] | [174] | 0 | hSpCas9 | negative selection | 11692483 | 112184689 | 112184712 | 12 | - | 28162770 | HEL | viability | AAGGCCTGCAACGCCCACGGCGG | HECTD4 | ENSG00000173064 | 0.08233343552317954 | [232] | [157] | 0 | hSpCas9 | negative selection | 11692484 | 112179228 | 112179251 | 12 | + | 28162770 | HEL | viability | GAGGTGGAGGAGGTTGCCTGGGG | HECTD4 | ENSG00000173064 | 0.05777633127920079 | [431] | [287] | 0 | hSpCas9 | negative selection | 11692485 | 112167496 | 112167519 | 12 | - | 28162770 | HEL | viability | GAGCCCCATCACCTACGGGGAGG | HECTD4 | ENSG00000173064 | -0.7456635407750201 | [321] | [122] | -5 | hSpCas9 | negative selection | 11692486 | 112319414 | 112319437 | 12 | + | 28162770 | HEL | viability | GCAGTTATGTTACAGAGAGAGGG | HECTD4 | ENSG00000173064 | -0.6011867508857323 | [224] | [94] | -4 | hSpCas9 | negative selection | 11692487 | 112308800 | 112308823 | 12 | + | 28162770 | HEL | viability | TATCGAAAGAGACAGGCCGGTGG | HECTD4 | ENSG00000173064 | 0.780242355750292 | [169] | [186] | 6 | hSpCas9 | negative selection | 11692488 | 112306180 | 112306203 | 12 | + | 28162770 | HEL | viability | TCATGGTGCTGCCAATGGGGAGG | HECTD4 | ENSG00000173064 | 0.4758879741479935 | [292] | [260] | 4 | hSpCas9 | negative selection | 11692489 | 112210171 | 112210194 | 12 | + | 28162770 | MV411 | viability | ACAGGTCAGCAGCATTGCGGTGG | HECTD4 | ENSG00000173064 | -0.28141984805323017 | [579] | [401] | -2 | hSpCas9 | negative selection | 11861846 | 112283159 | 112283182 | 12 | + | 28162770 | MV411 | viability | AGCAAGCGTTGCTGACGGGGAGG | HECTD4 | ENSG00000173064 | 0.9140138170575833 | [62] | [99] | 7 | hSpCas9 | negative selection | 11861847 | 112190874 | 112190897 | 12 | + | 28162770 | MV411 | viability | GGACAGCAGCTGCTCTGCGAAGG | HECTD4 | ENSG00000173064 | -0.45488190057653966 | [575] | [353] | -3 | hSpCas9 | negative selection | 11861848 | 112184882 | 112184905 | 12 | + | 28162770 | MV411 | viability | TGAGCAGGGTGAGTGCGCGGTGG | HECTD4 | ENSG00000173064 | -0.12049571336902576 | [230] | [178] | -1 | hSpCas9 | negative selection | 11861849 | 112184689 | 112184712 | 12 | - | 28162770 | MV411 | viability | AAGGCCTGCAACGCCCACGGCGG | HECTD4 | ENSG00000173064 | 0.7945567003592588 | [205] | [300] | 7 | hSpCas9 | negative selection | 11861850 | 112179228 | 112179251 | 12 | + | 28162770 | MV411 | viability | GAGGTGGAGGAGGTTGCCTGGGG | HECTD4 | ENSG00000173064 | -0.91841318915228 | [441] | [196] | -6 | hSpCas9 | negative selection | 11861851 | 112167496 | 112167519 | 12 | - | 28162770 | MV411 | viability | GAGCCCCATCACCTACGGGGAGG | HECTD4 | ENSG00000173064 | -1.4931758203985752 | [263] | [78] | -7 | hSpCas9 | negative selection | 11861852 | 112319414 | 112319437 | 12 | + | 28162770 | MV411 | viability | GCAGTTATGTTACAGAGAGAGGG | HECTD4 | ENSG00000173064 | -0.05147389137961521 | [170] | [138] | 0 | hSpCas9 | negative selection | 11861853 | 112308800 | 112308823 | 12 | + | 28162770 | MV411 | viability | TATCGAAAGAGACAGGCCGGTGG | HECTD4 | ENSG00000173064 | 0.3771286274224121 | [201] | [220] | 3 | hSpCas9 | negative selection | 11861854 | 112306180 | 112306203 | 12 | + | 28162770 | MV411 | viability | TCATGGTGCTGCCAATGGGGAGG | HECTD4 | ENSG00000173064 | -0.08491791555492517 | [242] | [192] | 0 | hSpCas9 | negative selection | 11861855 | 112210171 | 112210194 | 12 | + | 28162770 | MONOMAC1 | viability | ACAGGTCAGCAGCATTGCGGTGG | HECTD4 | ENSG00000173064 | 0.04902448017052685 | [284] | [337] | 0 | hSpCas9 | negative selection | 12031212 | 112283159 | 112283182 | 12 | + | 28162770 | MONOMAC1 | viability | AGCAAGCGTTGCTGACGGGGAGG | HECTD4 | ENSG00000173064 | -0.3372145051078139 | [53] | [48] | -3 | hSpCas9 | negative selection | 12031213 | 112190874 | 112190897 | 12 | + | 28162770 | MONOMAC1 | viability | GGACAGCAGCTGCTCTGCGAAGG | HECTD4 | ENSG00000173064 | -1.3756007667757386 | [334] | [147] | -8 | hSpCas9 | negative selection | 12031214 | 112184882 | 112184905 | 12 | + | 28162770 | MONOMAC1 | viability | TGAGCAGGGTGAGTGCGCGGTGG | HECTD4 | ENSG00000173064 | -0.6376094384455351 | [189] | [139] | -5 | hSpCas9 | negative selection | 12031215 | 112184689 | 112184712 | 12 | - | 28162770 | MONOMAC1 | viability | AAGGCCTGCAACGCCCACGGCGG | HECTD4 | ENSG00000173064 | -0.6120743463383974 | [119] | [89] | -5 | hSpCas9 | negative selection | 12031216 | 112179228 | 112179251 | 12 | + | 28162770 | MONOMAC1 | viability | GAGGTGGAGGAGGTTGCCTGGGG | HECTD4 | ENSG00000173064 | -0.5024498551638994 | [303] | [245] | -4 | hSpCas9 | negative selection | 12031217 | 112167496 | 112167519 | 12 | - | 28162770 | MONOMAC1 | viability | GAGCCCCATCACCTACGGGGAGG | HECTD4 | ENSG00000173064 | -0.2958902339858389 | [150] | [140] | -3 | hSpCas9 | negative selection | 12031218 | 112319414 | 112319437 | 12 | + | 28162770 | MONOMAC1 | viability | GCAGTTATGTTACAGAGAGAGGG | HECTD4 | ENSG00000173064 | 0.7661263847600748 | [118] | [231] | 7 | hSpCas9 | negative selection | 12031219 | 112308800 | 112308823 | 12 | + | 28162770 | MONOMAC1 | viability | TATCGAAAGAGACAGGCCGGTGG | HECTD4 | ENSG00000173064 | -0.08923355752503889 | [115] | [124] | -1 | hSpCas9 | negative selection | 12031220 | 112306180 | 112306203 | 12 | + | 28162770 | MONOMAC1 | viability | TCATGGTGCTGCCAATGGGGAGG | HECTD4 | ENSG00000173064 | -0.25061788726439777 | [191] | [184] | -2 | hSpCas9 | negative selection | 12031221 | 112210171 | 112210194 | 12 | + | 28162770 | OCIAML2 | viability | ACAGGTCAGCAGCATTGCGGTGG | HECTD4 | ENSG00000173064 | 0.25959562268703795 | [117] | [782] | 2 | hSpCas9 | negative selection | 12200578 | 112283159 | 112283182 | 12 | + | 28162770 | OCIAML2 | viability | AGCAAGCGTTGCTGACGGGGAGG | HECTD4 | ENSG00000173064 | 0.17322636453256346 | [15] | [99] | 1 | hSpCas9 | negative selection | 12200579 | 112190874 | 112190897 | 12 | + | 28162770 | OCIAML2 | viability | GGACAGCAGCTGCTCTGCGAAGG | HECTD4 | ENSG00000173064 | -0.8061469848774787 | [99] | [316] | -5 | hSpCas9 | negative selection | 12200580 | 112184882 | 112184905 | 12 | + | 28162770 | OCIAML2 | viability | TGAGCAGGGTGAGTGCGCGGTGG | HECTD4 | ENSG00000173064 | -0.29309163968997365 | [41] | [189] | -2 | hSpCas9 | negative selection | 12200581 | 112184689 | 112184712 | 12 | - | 28162770 | OCIAML2 | viability | AAGGCCTGCAACGCCCACGGCGG | HECTD4 | ENSG00000173064 | 0.5482292020091546 | [37] | [307] | 5 | hSpCas9 | negative selection | 12200582 | 112179228 | 112179251 | 12 | + | 28162770 | OCIAML2 | viability | GAGGTGGAGGAGGTTGCCTGGGG | HECTD4 | ENSG00000173064 | -0.430215556796253 | [87] | [361] | -3 | hSpCas9 | negative selection | 12200583 | 112167496 | 112167519 | 12 | - | 28162770 | OCIAML2 | viability | GAGCCCCATCACCTACGGGGAGG | HECTD4 | ENSG00000173064 | -0.655369705099211 | [51] | [182] | -5 | hSpCas9 | negative selection | 12200584 | 112319414 | 112319437 | 12 | + | 28162770 | OCIAML2 | viability | GCAGTTATGTTACAGAGAGAGGG | HECTD4 | ENSG00000173064 | 0.7703782742616337 | [32] | [311] | 7 | hSpCas9 | negative selection | 12200585 | 112308800 | 112308823 | 12 | + | 28162770 | OCIAML2 | viability | TATCGAAAGAGACAGGCCGGTGG | HECTD4 | ENSG00000173064 | -0.1657752437137402 | [50] | [251] | -1 | hSpCas9 | negative selection | 12200586 | 112306180 | 112306203 | 12 | + | 28162770 | OCIAML2 | viability | TCATGGTGCTGCCAATGGGGAGG | HECTD4 | ENSG00000173064 | 1.0846409905421897 | [44] | [528] | 9 | hSpCas9 | negative selection | 12200587 | 112210171 | 112210194 | 12 | + | 28162770 | OCIAML3 | viability | ACAGGTCAGCAGCATTGCGGTGG | HECTD4 | ENSG00000173064 | 0.04451813681240124 | [140] | [438] | 0 | hSpCas9 | negative selection | 12369944 | 112283159 | 112283182 | 12 | + | 28162770 | OCIAML3 | viability | AGCAAGCGTTGCTGACGGGGAGG | HECTD4 | ENSG00000173064 | 0.4503864790342902 | [23] | [98] | 4 | hSpCas9 | negative selection | 12369945 | 112190874 | 112190897 | 12 | + | 28162770 | OCIAML3 | viability | GGACAGCAGCTGCTCTGCGAAGG | HECTD4 | ENSG00000173064 | -1.3091265321921204 | [141] | [172] | -7 | hSpCas9 | negative selection | 12369946 | 112184882 | 112184905 | 12 | + | 28162770 | OCIAML3 | viability | TGAGCAGGGTGAGTGCGCGGTGG | HECTD4 | ENSG00000173064 | 0.4915680913819108 | [44] | [190] | 4 | hSpCas9 | negative selection | 12369947 | 112184689 | 112184712 | 12 | - | 28162770 | OCIAML3 | viability | AAGGCCTGCAACGCCCACGGCGG | HECTD4 | ENSG00000173064 | 0.37019163824798995 | [50] | [198] | 3 | hSpCas9 | negative selection | 12369948 | 112179228 | 112179251 | 12 | + | 28162770 | OCIAML3 | viability | GAGGTGGAGGAGGTTGCCTGGGG | HECTD4 | ENSG00000173064 | 0.60010682668522 | [91] | [420] | 5 | hSpCas9 | negative selection | 12369949 | 112167496 | 112167519 | 12 | - | 28162770 | OCIAML3 | viability | GAGCCCCATCACCTACGGGGAGG | HECTD4 | ENSG00000173064 | -2.352999540820368 | [65] | [38] | -9 | hSpCas9 | negative selection | 12369950 | 112319414 | 112319437 | 12 | + | 28162770 | OCIAML3 | viability | GCAGTTATGTTACAGAGAGAGGG | HECTD4 | ENSG00000173064 | 0.4833512423820765 | [58] | [248] | 4 | hSpCas9 | negative selection | 12369951 | 112308800 | 112308823 | 12 | + | 28162770 | OCIAML3 | viability | TATCGAAAGAGACAGGCCGGTGG | HECTD4 | ENSG00000173064 | 0.7827129274035789 | [61] | [321] | 7 | hSpCas9 | negative selection | 12369952 | 112306180 | 112306203 | 12 | + | 28162770 | OCIAML3 | viability | TCATGGTGCTGCCAATGGGGAGG | HECTD4 | ENSG00000173064 | 0.5090858526399401 | [80] | [347] | 5 | hSpCas9 | negative selection | 12369953 |