Gene2Function

Crispr

Gene Info

Species:Human (Homo sapiens)
GeneID:3105
Symbol:HLA-A
Description:major histocompatibility complex, class I, A

DataSource: http://genomecrispr.dkfz.de/#!/results/HLA-A

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
29935492	29935515	CHR_HSCHR6_MHC_APD_CTG1	+	26472758	Jiyoye	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000229215	0.26033399317660244	[216]	[195]	2	hSpCas9	negative selection	71729
29932879	29932902	CHR_HSCHR6_MHC_COX_CTG1	+	26472758	Jiyoye	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000224320	0.26033399317660244	[216]	[195]	2	hSpCas9	negative selection	71730
29943338	29943361	6	+	26472758	Jiyoye	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	0.26033399317660244	[216]	[195]	2	hSpCas9	negative selection	71731
29932286	29932309	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	Jiyoye	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000231834	0.26033399317660244	[216]	[195]	2	hSpCas9	negative selection	71732
29932616	29932639	CHR_HSCHR6_MHC_SSTO_CTG1	+	26472758	Jiyoye	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000223980	0.26033399317660244	[216]	[195]	2	hSpCas9	negative selection	71733
30021777	30021800	CHR_HSCHR6_MHC_MCF_CTG1	+	26472758	Jiyoye	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000227715	0.23490643959526192	[230]	[204]	1	hSpCas9	negative selection	71734
29933250	29933273	CHR_HSCHR6_MHC_DBB_CTG1	+	26472758	Jiyoye	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000235657	0.23490643959526192	[230]	[204]	1	hSpCas9	negative selection	71735
29932238	29932261	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	Jiyoye	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000231834	0.23490643959526192	[230]	[204]	1	hSpCas9	negative selection	71736
29943290	29943313	6	+	26472758	Jiyoye	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	0.23490643959526192	[230]	[204]	1	hSpCas9	negative selection	71737
29932921	29932944	CHR_HSCHR6_MHC_COX_CTG1	+	26472758	Jiyoye	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000224320	-0.6836780489452402	[212]	[99]	-5	hSpCas9	negative selection	71738
29943380	29943403	6	+	26472758	Jiyoye	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-0.6836780489452402	[212]	[99]	-5	hSpCas9	negative selection	71739
29932746	29932769	CHR_HSCHR6_MHC_QBL_CTG1	+	26472758	Jiyoye	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206505	-0.6836780489452402	[212]	[99]	-5	hSpCas9	negative selection	71740
29932658	29932681	CHR_HSCHR6_MHC_SSTO_CTG1	+	26472758	Jiyoye	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000223980	-0.6836780489452402	[212]	[99]	-5	hSpCas9	negative selection	71741
29932328	29932351	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	Jiyoye	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000231834	-0.6836780489452402	[212]	[99]	-5	hSpCas9	negative selection	71742
30021867	30021890	CHR_HSCHR6_MHC_MCF_CTG1	+	26472758	Jiyoye	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000227715	-0.6836780489452402	[212]	[99]	-5	hSpCas9	negative selection	71743
29933340	29933363	CHR_HSCHR6_MHC_DBB_CTG1	+	26472758	Jiyoye	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000235657	-0.6836780489452402	[212]	[99]	-5	hSpCas9	negative selection	71744
29935534	29935557	CHR_HSCHR6_MHC_APD_CTG1	+	26472758	Jiyoye	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000229215	-0.6836780489452402	[212]	[99]	-5	hSpCas9	negative selection	71745
29933482	29933505	CHR_HSCHR6_MHC_DBB_CTG1	+	26472758	Jiyoye	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000235657	-0.17118438439103575	[108]	[72]	-1	hSpCas9	negative selection	71746
29932800	29932823	CHR_HSCHR6_MHC_SSTO_CTG1	+	26472758	Jiyoye	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000223980	-0.17118438439103575	[108]	[72]	-1	hSpCas9	negative selection	71747
29932470	29932493	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	Jiyoye	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000231834	-0.17118438439103575	[108]	[72]	-1	hSpCas9	negative selection	71748
29943522	29943545	6	+	26472758	Jiyoye	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	-0.17118438439103575	[108]	[72]	-1	hSpCas9	negative selection	71749
29932888	29932911	CHR_HSCHR6_MHC_QBL_CTG1	+	26472758	Jiyoye	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206505	-0.17118438439103575	[108]	[72]	-1	hSpCas9	negative selection	71750
29935676	29935699	CHR_HSCHR6_MHC_APD_CTG1	+	26472758	Jiyoye	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000229215	-0.17118438439103575	[108]	[72]	-1	hSpCas9	negative selection	71751
29933063	29933086	CHR_HSCHR6_MHC_COX_CTG1	+	26472758	Jiyoye	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000224320	-0.17118438439103575	[108]	[72]	-1	hSpCas9	negative selection	71752
30022009	30022032	CHR_HSCHR6_MHC_MCF_CTG1	+	26472758	Jiyoye	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000227715	-0.17118438439103575	[108]	[72]	-1	hSpCas9	negative selection	71753
29935492	29935515	CHR_HSCHR6_MHC_APD_CTG1	+	26472758	KBM7	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000229215	0.7513210515403488	[803,947]	[597,795]	7	hSpCas9	negative selection	262847
29932879	29932902	CHR_HSCHR6_MHC_COX_CTG1	+	26472758	KBM7	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000224320	0.7513210515403488	[803,947]	[597,795]	7	hSpCas9	negative selection	262848
29943338	29943361	6	+	26472758	KBM7	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	0.7513210515403488	[803,947]	[597,795]	7	hSpCas9	negative selection	262849
29932286	29932309	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	KBM7	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000231834	0.7513210515403488	[803,947]	[597,795]	7	hSpCas9	negative selection	262850
29932616	29932639	CHR_HSCHR6_MHC_SSTO_CTG1	+	26472758	KBM7	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000223980	0.7513210515403488	[803,947]	[597,795]	7	hSpCas9	negative selection	262851
30021777	30021800	CHR_HSCHR6_MHC_MCF_CTG1	+	26472758	KBM7	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000227715	-0.15009969582948385	[808,571]	[262,311]	-1	hSpCas9	negative selection	262852
29933250	29933273	CHR_HSCHR6_MHC_DBB_CTG1	+	26472758	KBM7	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000235657	-0.15009969582948385	[808,571]	[262,311]	-1	hSpCas9	negative selection	262853
29932238	29932261	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	KBM7	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000231834	-0.15009969582948385	[808,571]	[262,311]	-1	hSpCas9	negative selection	262854
29943290	29943313	6	+	26472758	KBM7	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	-0.15009969582948385	[808,571]	[262,311]	-1	hSpCas9	negative selection	262855
29932921	29932944	CHR_HSCHR6_MHC_COX_CTG1	+	26472758	KBM7	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000224320	-1.0564569395293992	[427,449]	[71,124]	-7	hSpCas9	negative selection	262856
29943380	29943403	6	+	26472758	KBM7	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-1.0564569395293992	[427,449]	[71,124]	-7	hSpCas9	negative selection	262857
29932746	29932769	CHR_HSCHR6_MHC_QBL_CTG1	+	26472758	KBM7	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206505	-1.0564569395293992	[427,449]	[71,124]	-7	hSpCas9	negative selection	262858
29932658	29932681	CHR_HSCHR6_MHC_SSTO_CTG1	+	26472758	KBM7	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000223980	-1.0564569395293992	[427,449]	[71,124]	-7	hSpCas9	negative selection	262859
29932328	29932351	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	KBM7	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000231834	-1.0564569395293992	[427,449]	[71,124]	-7	hSpCas9	negative selection	262860
30021867	30021890	CHR_HSCHR6_MHC_MCF_CTG1	+	26472758	KBM7	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000227715	-1.0564569395293992	[427,449]	[71,124]	-7	hSpCas9	negative selection	262861
29933340	29933363	CHR_HSCHR6_MHC_DBB_CTG1	+	26472758	KBM7	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000235657	-1.0564569395293992	[427,449]	[71,124]	-7	hSpCas9	negative selection	262862
29935534	29935557	CHR_HSCHR6_MHC_APD_CTG1	+	26472758	KBM7	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000229215	-1.0564569395293992	[427,449]	[71,124]	-7	hSpCas9	negative selection	262863
29933482	29933505	CHR_HSCHR6_MHC_DBB_CTG1	+	26472758	KBM7	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000235657	0.20069909485680776	[298,355]	[133,219]	2	hSpCas9	negative selection	262864
29932800	29932823	CHR_HSCHR6_MHC_SSTO_CTG1	+	26472758	KBM7	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000223980	0.20069909485680776	[298,355]	[133,219]	2	hSpCas9	negative selection	262865
29932470	29932493	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	KBM7	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000231834	0.20069909485680776	[298,355]	[133,219]	2	hSpCas9	negative selection	262866
29943522	29943545	6	+	26472758	KBM7	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	0.20069909485680776	[298,355]	[133,219]	2	hSpCas9	negative selection	262867
29932888	29932911	CHR_HSCHR6_MHC_QBL_CTG1	+	26472758	KBM7	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206505	0.20069909485680776	[298,355]	[133,219]	2	hSpCas9	negative selection	262868
29935676	29935699	CHR_HSCHR6_MHC_APD_CTG1	+	26472758	KBM7	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000229215	0.20069909485680776	[298,355]	[133,219]	2	hSpCas9	negative selection	262869
29933063	29933086	CHR_HSCHR6_MHC_COX_CTG1	+	26472758	KBM7	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000224320	0.20069909485680776	[298,355]	[133,219]	2	hSpCas9	negative selection	262870
30022009	30022032	CHR_HSCHR6_MHC_MCF_CTG1	+	26472758	KBM7	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000227715	0.20069909485680776	[298,355]	[133,219]	2	hSpCas9	negative selection	262871
29935492	29935515	CHR_HSCHR6_MHC_APD_CTG1	+	26472758	Raji	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000229215	-0.09648879799205046	[386]	[83]	-1	hSpCas9	negative selection	453965
29932879	29932902	CHR_HSCHR6_MHC_COX_CTG1	+	26472758	Raji	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000224320	-0.09648879799205046	[386]	[83]	-1	hSpCas9	negative selection	453966
29943338	29943361	6	+	26472758	Raji	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	-0.09648879799205046	[386]	[83]	-1	hSpCas9	negative selection	453967
29932286	29932309	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	Raji	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000231834	-0.09648879799205046	[386]	[83]	-1	hSpCas9	negative selection	453968
29932616	29932639	CHR_HSCHR6_MHC_SSTO_CTG1	+	26472758	Raji	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000223980	-0.09648879799205046	[386]	[83]	-1	hSpCas9	negative selection	453969
30021777	30021800	CHR_HSCHR6_MHC_MCF_CTG1	+	26472758	Raji	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000227715	-0.5061481175443278	[458]	[74]	-4	hSpCas9	negative selection	453970
29933250	29933273	CHR_HSCHR6_MHC_DBB_CTG1	+	26472758	Raji	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000235657	-0.5061481175443278	[458]	[74]	-4	hSpCas9	negative selection	453971
29932238	29932261	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	Raji	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000231834	-0.5061481175443278	[458]	[74]	-4	hSpCas9	negative selection	453972
29943290	29943313	6	+	26472758	Raji	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	-0.5061481175443278	[458]	[74]	-4	hSpCas9	negative selection	453973
29932921	29932944	CHR_HSCHR6_MHC_COX_CTG1	+	26472758	Raji	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000224320	0.043253197953883854	[275]	[65]	0	hSpCas9	negative selection	453974
29943380	29943403	6	+	26472758	Raji	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	0.043253197953883854	[275]	[65]	0	hSpCas9	negative selection	453975
29932746	29932769	CHR_HSCHR6_MHC_QBL_CTG1	+	26472758	Raji	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206505	0.043253197953883854	[275]	[65]	0	hSpCas9	negative selection	453976
29932658	29932681	CHR_HSCHR6_MHC_SSTO_CTG1	+	26472758	Raji	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000223980	0.043253197953883854	[275]	[65]	0	hSpCas9	negative selection	453977
29932328	29932351	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	Raji	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000231834	0.043253197953883854	[275]	[65]	0	hSpCas9	negative selection	453978
30021867	30021890	CHR_HSCHR6_MHC_MCF_CTG1	+	26472758	Raji	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000227715	0.043253197953883854	[275]	[65]	0	hSpCas9	negative selection	453979
29933340	29933363	CHR_HSCHR6_MHC_DBB_CTG1	+	26472758	Raji	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000235657	0.043253197953883854	[275]	[65]	0	hSpCas9	negative selection	453980
29935534	29935557	CHR_HSCHR6_MHC_APD_CTG1	+	26472758	Raji	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000229215	0.043253197953883854	[275]	[65]	0	hSpCas9	negative selection	453981
29933482	29933505	CHR_HSCHR6_MHC_DBB_CTG1	+	26472758	Raji	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000235657	0.3911765013741908	[114]	[34]	4	hSpCas9	negative selection	453982
29932800	29932823	CHR_HSCHR6_MHC_SSTO_CTG1	+	26472758	Raji	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000223980	0.3911765013741908	[114]	[34]	4	hSpCas9	negative selection	453983
29932470	29932493	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	Raji	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000231834	0.3911765013741908	[114]	[34]	4	hSpCas9	negative selection	453984
29943522	29943545	6	+	26472758	Raji	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	0.3911765013741908	[114]	[34]	4	hSpCas9	negative selection	453985
29932888	29932911	CHR_HSCHR6_MHC_QBL_CTG1	+	26472758	Raji	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206505	0.3911765013741908	[114]	[34]	4	hSpCas9	negative selection	453986
29935676	29935699	CHR_HSCHR6_MHC_APD_CTG1	+	26472758	Raji	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000229215	0.3911765013741908	[114]	[34]	4	hSpCas9	negative selection	453987
29933063	29933086	CHR_HSCHR6_MHC_COX_CTG1	+	26472758	Raji	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000224320	0.3911765013741908	[114]	[34]	4	hSpCas9	negative selection	453988
30022009	30022032	CHR_HSCHR6_MHC_MCF_CTG1	+	26472758	Raji	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000227715	0.3911765013741908	[114]	[34]	4	hSpCas9	negative selection	453989
29935492	29935515	CHR_HSCHR6_MHC_APD_CTG1	+	26472758	K562	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000229215	0.2498731577585549	[527]	[529]	2	hSpCas9	negative selection	645083
29932879	29932902	CHR_HSCHR6_MHC_COX_CTG1	+	26472758	K562	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000224320	0.2498731577585549	[527]	[529]	2	hSpCas9	negative selection	645084
29943338	29943361	6	+	26472758	K562	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	0.2498731577585549	[527]	[529]	2	hSpCas9	negative selection	645085
29932286	29932309	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	K562	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000231834	0.2498731577585549	[527]	[529]	2	hSpCas9	negative selection	645086
29932616	29932639	CHR_HSCHR6_MHC_SSTO_CTG1	+	26472758	K562	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000223980	0.2498731577585549	[527]	[529]	2	hSpCas9	negative selection	645087
30021777	30021800	CHR_HSCHR6_MHC_MCF_CTG1	+	26472758	K562	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000227715	0.7397203027718043	[519]	[732]	6	hSpCas9	negative selection	645088
29933250	29933273	CHR_HSCHR6_MHC_DBB_CTG1	+	26472758	K562	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000235657	0.7397203027718043	[519]	[732]	6	hSpCas9	negative selection	645089
29932238	29932261	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	K562	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000231834	0.7397203027718043	[519]	[732]	6	hSpCas9	negative selection	645090
29943290	29943313	6	+	26472758	K562	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	0.7397203027718043	[519]	[732]	6	hSpCas9	negative selection	645091
29932921	29932944	CHR_HSCHR6_MHC_COX_CTG1	+	26472758	K562	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000224320	-2.069582451449287	[362]	[72]	-7	hSpCas9	negative selection	645092
29943380	29943403	6	+	26472758	K562	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-2.069582451449287	[362]	[72]	-7	hSpCas9	negative selection	645093
29932746	29932769	CHR_HSCHR6_MHC_QBL_CTG1	+	26472758	K562	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206505	-2.069582451449287	[362]	[72]	-7	hSpCas9	negative selection	645094
29932658	29932681	CHR_HSCHR6_MHC_SSTO_CTG1	+	26472758	K562	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000223980	-2.069582451449287	[362]	[72]	-7	hSpCas9	negative selection	645095
29932328	29932351	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	K562	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000231834	-2.069582451449287	[362]	[72]	-7	hSpCas9	negative selection	645096
30021867	30021890	CHR_HSCHR6_MHC_MCF_CTG1	+	26472758	K562	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000227715	-2.069582451449287	[362]	[72]	-7	hSpCas9	negative selection	645097
29933340	29933363	CHR_HSCHR6_MHC_DBB_CTG1	+	26472758	K562	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000235657	-2.069582451449287	[362]	[72]	-7	hSpCas9	negative selection	645098
29935534	29935557	CHR_HSCHR6_MHC_APD_CTG1	+	26472758	K562	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000229215	-2.069582451449287	[362]	[72]	-7	hSpCas9	negative selection	645099
29933482	29933505	CHR_HSCHR6_MHC_DBB_CTG1	+	26472758	K562	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000235657	-0.4400794466056237	[269]	[167]	-3	hSpCas9	negative selection	645100
29932800	29932823	CHR_HSCHR6_MHC_SSTO_CTG1	+	26472758	K562	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000223980	-0.4400794466056237	[269]	[167]	-3	hSpCas9	negative selection	645101
29932470	29932493	CHR_HSCHR6_MHC_MANN_CTG1	+	26472758	K562	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000231834	-0.4400794466056237	[269]	[167]	-3	hSpCas9	negative selection	645102
29943522	29943545	6	+	26472758	K562	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	-0.4400794466056237	[269]	[167]	-3	hSpCas9	negative selection	645103
29932888	29932911	CHR_HSCHR6_MHC_QBL_CTG1	+	26472758	K562	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206505	-0.4400794466056237	[269]	[167]	-3	hSpCas9	negative selection	645104
29935676	29935699	CHR_HSCHR6_MHC_APD_CTG1	+	26472758	K562	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000229215	-0.4400794466056237	[269]	[167]	-3	hSpCas9	negative selection	645105
29933063	29933086	CHR_HSCHR6_MHC_COX_CTG1	+	26472758	K562	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000224320	-0.4400794466056237	[269]	[167]	-3	hSpCas9	negative selection	645106
30022009	30022032	CHR_HSCHR6_MHC_MCF_CTG1	+	26472758	K562	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000227715	-0.4400794466056237	[269]	[167]	-3	hSpCas9	negative selection	645107
29900071	29900094	CHR_HSCHR6_MHC_MCF_CTG1	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGAACTTGCTTTAGAGCACTGG	HLA-A	ENSG00000227715	-2.3733052001331805	[80,484]	[4,18]	-9	dCas9-VP64	positive selection	2388610
29900071	29900094	CHR_HSCHR6_MHC_MCF_CTG1	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGAACTTGCTTTAGAGCACTGG	HLA-A	ENSG00000227715	-1.148037070079038	[223,291]	[45,29]	-9	dCas9-VP64	positive selection	2483865
29943285	29943308	6	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GATAATGTATGGCTGCGACGTGG	HLA-A	ENSG00000206503	-0.022019074310110937	[4,3]	[3,2]	0	hSpCas9	positive selection	2993578
29943277	29943300	6	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCAGCCATACATTATCTGGATGG	HLA-A	ENSG00000206503	0.1283969965413314	[3,3]	[3,3]	2	hSpCas9	positive selection	2993579
29943381	29943404	6	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	0.04599159610608159	[3,3]	[3,3]	1	hSpCas9	positive selection	2993580
29943285	29943308	6	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GATAATGTATGGCTGCGACGTGG	HLA-A	ENSG00000206503	-0.26972943539336613	[4,4]	[4,0]	-4	hSpCas9	positive selection	3061436
29943277	29943300	6	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCAGCCATACATTATCTGGATGG	HLA-A	ENSG00000206503	0.3330179835778697	[3,3]	[2,3]	6	hSpCas9	positive selection	3061437
29943381	29943404	6	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-0.38679001901175725	[3,3]	[3,0]	-5	hSpCas9	positive selection	3061438
29943323	29943346		-	24336571	A375	resistance to PLX after 7 days	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.33296238214816143	[5,6]	[8,7]	8	hSpCas9	positive selection	3119195
29943333	29943356		+	24336571	A375	resistance to PLX after 7 days	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.27582009918734823	[16,14]	[13,12]	-7	hSpCas9	positive selection	3119196
29943323	29943346		-	24336571	A375	resistance to PLX after 14 days	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	-0.7038820452469949	[9,13]	[2,2]	-7	hSpCas9	positive selection	3176988
29943333	29943356		+	24336571	A375	resistance to PLX after 14 days	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-1.1199186825167662	[18,15]	[2,3]	-9	hSpCas9	positive selection	3176989
29943323	29943346		-	24336571	A375	viability after 7 days	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.2770679466134739	[5]	[5,6]	4	hSpCas9	negative selection	3234781
29943333	29943356		+	24336571	A375	viability after 7 days	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.2801972818529875	[13]	[16,14]	4	hSpCas9	negative selection	3234782
29943323	29943346		-	24336571	A375	viability after 14 days	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	1.1244343501634608	[5]	[9,13]	9	hSpCas9	negative selection	3292574
29943333	29943356		+	24336571	A375	viability after 14 days	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.40878515075647837	[13]	[18,15]	5	hSpCas9	negative selection	3292575
29943323	29943346	6	-	27383988	293T	resistance to West Nile virus (flavivirus)	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.2916928047425645	[122,126]	[0,0]	1	hSpCas9	positive selection	3353627
29943333	29943356	6	+	27383988	293T	resistance to West Nile virus (flavivirus)	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.716849916804738	[105,79]	[0,0]	3	hSpCas9	positive selection	3353628
29944386	29944409	6	-	27383988	293T	resistance to West Nile virus (flavivirus)	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.9618423090163265	[297,297]	[0,0]	-6	hSpCas9	positive selection	3372829
29944147	29944170	6	+	27383988	293T	resistance to West Nile virus (flavivirus)	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	2.155788184983773	[205,205]	[5,5]	7	hSpCas9	positive selection	3372830
29943284	29943307	6	+	26780180	HT29	viability (Avana library 4 designs)	GATAATGTATGGCTGCGACGTGG	HLA-A	ENSG00000206503	0.0982135294847137	[]	[]	0	hSpCas9	negative selection	3430860
29943277	29943300	6	-	26780180	HT29	viability (Avana library 4 designs)	GCAGCCATACATTATCTGGATGG	HLA-A	ENSG00000206503	-0.777287719962756	[]	[]	-9	hSpCas9	negative selection	3430861
29943380	29943403	6	+	26780180	HT29	viability (Avana library 4 designs)	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	1.80854286587738	[]	[]	7	hSpCas9	negative selection	3430862
29943284	29943307	6	+	26780180	A375	viability (Avana lentiCRISPRv2)	GATAATGTATGGCTGCGACGTGG	HLA-A	ENSG00000206503	1.82621966239824	[]	[]	2	hSpCas9	negative selection	3516234
29943380	29943403	6	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	0.928390244331168	[]	[]	1	hSpCas9	negative selection	3516235
29943277	29943300	6	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCAGCCATACATTATCTGGATGG	HLA-A	ENSG00000206503	-0.185906815035163	[]	[]	0	hSpCas9	negative selection	3516236
29943284	29943307	6	+	26780180	A375	viability (Avana lentiGuide)	GATAATGTATGGCTGCGACGTGG	HLA-A	ENSG00000206503	0.222692900570522	[]	[]	0	hSpCas9	negative selection	3624893
29943380	29943403	6	+	26780180	A375	viability (Avana lentiGuide)	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	8.95398730111975	[]	[]	6	hSpCas9	negative selection	3624894
29943277	29943300	6	-	26780180	A375	viability (Avana lentiGuide)	GCAGCCATACATTATCTGGATGG	HLA-A	ENSG00000206503	-5.15236342259029	[]	[]	-8	hSpCas9	negative selection	3624895
29943284	29943307	6	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GATAATGTATGGCTGCGACGTGG	HLA-A	ENSG00000206503	-0.0003211443145181292	[6]	[6,5]	0	hSpCas9	positive selection	3733552
29943380	29943403	6	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-0.16150726641362745	[5]	[5,4]	-3	hSpCas9	positive selection	3733553
29943277	29943300	6	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAGCCATACATTATCTGGATGG	HLA-A	ENSG00000206503	0.02171630298153862	[4]	[4,4]	0	hSpCas9	positive selection	3733554
29943284	29943307	6	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GATAATGTATGGCTGCGACGTGG	HLA-A	ENSG00000206503	0.1352659119153484	[6]	[6,5]	3	hSpCas9	positive selection	3842159
29943380	29943403	6	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-1.2986701217892844	[6]	[2,0]	-9	hSpCas9	positive selection	3842160
29943277	29943300	6	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAGCCATACATTATCTGGATGG	HLA-A	ENSG00000206503	0.35703881928635844	[5]	[6,5]	9	hSpCas9	positive selection	3842161
29944147	29944170	6	+	26780180	A375	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	1.81286266684486	[]	[]	9	hSpCas9	negative selection	3948173
29943323	29943346	6	-	26780180	A375	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.80377858576089	[]	[]	3	hSpCas9	negative selection	3948174
29943333	29943356	6	+	26780180	A375	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.836548530693265	[]	[]	3	hSpCas9	negative selection	3948175
29944386	29944409	6	-	26780180	A375	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	1.50619365489725	[]	[]	8	hSpCas9	negative selection	3948176
29944147	29944170	6	+	26780180	HT29	viability (GeCKOv2 library)	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	1.3591278392885	[]	[]	7	hSpCas9	negative selection	4056139
29943323	29943346	6	-	26780180	HT29	viability (GeCKOv2 library)	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.899277938944789	[]	[]	4	hSpCas9	negative selection	4056140
29943333	29943356	6	+	26780180	HT29	viability (GeCKOv2 library)	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.665545836445793	[]	[]	2	hSpCas9	negative selection	4056141
29944386	29944409	6	-	26780180	HT29	viability (GeCKOv2 library)	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.0688611502557947	[]	[]	-2	hSpCas9	negative selection	4056142
29943323	29943346	6	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	-0.18197179091841026	[2]	[1,1]	-4	hSpCas9	positive selection	4142683
29943333	29943356	6	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.09538140299647761	[3]	[2,1]	-2	hSpCas9	positive selection	4142684
29943323	29943346	6	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	1.2140278678068734	[1]	[0,0,0,3]	8	hSpCas9	positive selection	4206705
29943333	29943356	6	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	1.1890625463520024	[3]	[3,4,2,4]	8	hSpCas9	positive selection	4206706
29943323	29943346	6	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.459846207526017	[2]	[2,3]	8	hSpCas9	positive selection	4275273
29943333	29943356	6	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.08419425483846994	[3]	[2,1]	-2	hSpCas9	positive selection	4275274
29944386	29944409	6	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.19619154479509965	[4]	[3,2]	-4	hSpCas9	positive selection	4339535
29944147	29944170	6	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.44222298641385643	[3]	[2,1]	-7	hSpCas9	positive selection	4339536
29943286	29943308	6	+	27760321	OCIAML3	viability	TAATGTATGGCTGCGACGTGGG	HLA-A	ENSG00000206503	-1.0213509772129772	[637,602]	[214,270]	-7	hSpCas9	negative selection	4407262
29943317	29943339	6	+	27760321	OCIAML3	viability	GCGCTTCCTCCGCGGGTACCGG	HLA-A	ENSG00000206503	0.21755448098465435	[1085,1068]	[902,1085]	2	hSpCas9	negative selection	4407263
29943335	29943357	6	-	27760321	OCIAML3	viability	GCCGTCGTAGGCGTCCTGCCGG	HLA-A	ENSG00000206503	-0.1388293185651454	[626,541]	[351,494]	-1	hSpCas9	negative selection	4407264
29943286	29943308	6	+	27760321	OCIAML2	viability	TAATGTATGGCTGCGACGTGGG	HLA-A	ENSG00000206503	-1.966111031601398	[637,602]	[103,160]	-9	hSpCas9	negative selection	4490725
29943317	29943339	6	+	27760321	OCIAML2	viability	GCGCTTCCTCCGCGGGTACCGG	HLA-A	ENSG00000206503	0.8013037565354761	[1085,1068]	[1415,1663]	9	hSpCas9	negative selection	4490726
29943335	29943357	6	-	27760321	OCIAML2	viability	GCCGTCGTAGGCGTCCTGCCGG	HLA-A	ENSG00000206503	-0.15573721730593182	[626,541]	[418,428]	-2	hSpCas9	negative selection	4490727
29943286	29943308	6	+	27760321	MV411	viability	TAATGTATGGCTGCGACGTGGG	HLA-A	ENSG00000206503	-0.9525421116498053	[637,602]	[194,236]	-6	hSpCas9	negative selection	4574188
29943317	29943339	6	+	27760321	MV411	viability	GCGCTTCCTCCGCGGGTACCGG	HLA-A	ENSG00000206503	0.7216508205768422	[1085,1068]	[994,1446]	5	hSpCas9	negative selection	4574189
29943335	29943357	6	-	27760321	MV411	viability	GCCGTCGTAGGCGTCCTGCCGG	HLA-A	ENSG00000206503	-0.45228434934547446	[626,541]	[225,363]	-3	hSpCas9	negative selection	4574190
29943286	29943308	6	+	27760321	HL60	viability	TAATGTATGGCTGCGACGTGGG	HLA-A	ENSG00000206503	-1.0972417393330889	[637,602]	[241,231]	-8	hSpCas9	negative selection	4657651
29943317	29943339	6	+	27760321	HL60	viability	GCGCTTCCTCCGCGGGTACCGG	HLA-A	ENSG00000206503	0.1522961954728661	[1085,1068]	[889,1076]	1	hSpCas9	negative selection	4657652
29943335	29943357	6	-	27760321	HL60	viability	GCCGTCGTAGGCGTCCTGCCGG	HLA-A	ENSG00000206503	-0.44278225091531187	[626,541]	[261,443]	-5	hSpCas9	negative selection	4657653
29943286	29943308	6	+	27760321	HT1080	viability	TAATGTATGGCTGCGACGTGGG	HLA-A	ENSG00000206503	-2.5645604884496813	[602,470]	[7,66]	-7	hSpCas9	negative selection	4741114
29943317	29943339	6	+	27760321	HT1080	viability	GCGCTTCCTCCGCGGGTACCGG	HLA-A	ENSG00000206503	1.1343032024059445	[1068,833]	[716,957]	6	hSpCas9	negative selection	4741115
29943335	29943357	6	-	27760321	HT1080	viability	GCCGTCGTAGGCGTCCTGCCGG	HLA-A	ENSG00000206503	1.097076958799442	[541,422]	[530,279]	6	hSpCas9	negative selection	4741116
29943286	29943308	6	+	27760321	HT29	viability after 7 days	TAATGTATGGCTGCGACGTGGG	HLA-A	ENSG00000206503	-1.340304762609706	[602,470]	[532,182,142]	-9	hSpCas9	negative selection	4824577
29943317	29943339	6	+	27760321	HT29	viability after 7 days	GCGCTTCCTCCGCGGGTACCGG	HLA-A	ENSG00000206503	0.14873258177446358	[1068,833]	[1321,1488,1253]	2	hSpCas9	negative selection	4824578
29943335	29943357	6	-	27760321	HT29	viability after 7 days	GCCGTCGTAGGCGTCCTGCCGG	HLA-A	ENSG00000206503	-0.07135034081198183	[541,422]	[443,443,852]	-1	hSpCas9	negative selection	4824579
29943286	29943308	6	+	27760321	HT29	viability after 25 days	TAATGTATGGCTGCGACGTGGG	HLA-A	ENSG00000206503	-0.7393548903673139	[602,470]	[254,386,478]	-6	hSpCas9	negative selection	4908040
29943317	29943339	6	+	27760321	HT29	viability after 25 days	GCGCTTCCTCCGCGGGTACCGG	HLA-A	ENSG00000206503	0.3303921532495444	[1068,833]	[1344,1353,1405]	3	hSpCas9	negative selection	4908041
29943335	29943357	6	-	27760321	HT29	viability after 25 days	GCCGTCGTAGGCGTCCTGCCGG	HLA-A	ENSG00000206503	-0.14958798263527284	[541,422]	[465,619,395]	-1	hSpCas9	negative selection	4908042
29943286	29943308	6	+	27760321	HT29	viability after 22 days	TAATGTATGGCTGCGACGTGGG	HLA-A	ENSG00000206503	-0.5492144318168181	[602,470]	[294,377,604]	-5	hSpCas9	negative selection	4991503
29943317	29943339	6	+	27760321	HT29	viability after 22 days	GCGCTTCCTCCGCGGGTACCGG	HLA-A	ENSG00000206503	0.3829218068405682	[1068,833]	[1139,1616,1554]	4	hSpCas9	negative selection	4991504
29943335	29943357	6	-	27760321	HT29	viability after 22 days	GCCGTCGTAGGCGTCCTGCCGG	HLA-A	ENSG00000206503	-0.2585389798827752	[541,422]	[357,445,598]	-3	hSpCas9	negative selection	4991505
29943286	29943308	6	+	27760321	HT29	viability after 19 days	TAATGTATGGCTGCGACGTGGG	HLA-A	ENSG00000206503	-1.1987597228073645	[602,470]	[411,227,180]	-7	hSpCas9	negative selection	5074966
29943317	29943339	6	+	27760321	HT29	viability after 19 days	GCGCTTCCTCCGCGGGTACCGG	HLA-A	ENSG00000206503	0.31810675536476585	[1068,833]	[1581,1138,1370]	3	hSpCas9	negative selection	5074967
29943335	29943357	6	-	27760321	HT29	viability after 19 days	GCCGTCGTAGGCGTCCTGCCGG	HLA-A	ENSG00000206503	0.16987081247909308	[541,422]	[705,896,280]	1	hSpCas9	negative selection	5074968
29943286	29943308	6	+	27760321	HT29	viability after 16 days	TAATGTATGGCTGCGACGTGGG	HLA-A	ENSG00000206503	-0.7178498834760059	[602,470]	[461,364,277]	-6	hSpCas9	negative selection	5158429
29943317	29943339	6	+	27760321	HT29	viability after 16 days	GCGCTTCCTCCGCGGGTACCGG	HLA-A	ENSG00000206503	0.368667098533326	[1068,833]	[1387,1199,1540]	4	hSpCas9	negative selection	5158430
29943335	29943357	6	-	27760321	HT29	viability after 16 days	GCCGTCGTAGGCGTCCTGCCGG	HLA-A	ENSG00000206503	-0.3641917641786426	[541,422]	[548,470,248]	-4	hSpCas9	negative selection	5158431
29943286	29943308	6	+	27760321	HT29	viability after 13 days	TAATGTATGGCTGCGACGTGGG	HLA-A	ENSG00000206503	-0.3432802216891243	[602,470]	[632,470,375]	-4	hSpCas9	negative selection	5241892
29943317	29943339	6	+	27760321	HT29	viability after 13 days	GCGCTTCCTCCGCGGGTACCGG	HLA-A	ENSG00000206503	0.3727348357056415	[1068,833]	[1511,1580,1207]	5	hSpCas9	negative selection	5241893
29943335	29943357	6	-	27760321	HT29	viability after 13 days	GCCGTCGTAGGCGTCCTGCCGG	HLA-A	ENSG00000206503	-0.4263094893286969	[541,422]	[267,583,398]	-5	hSpCas9	negative selection	5241894
29943286	29943308	6	+	27760321	HT29	viability after 10 days	TAATGTATGGCTGCGACGTGGG	HLA-A	ENSG00000206503	-0.7383636655246159	[602,470]	[444,348,409]	-7	hSpCas9	negative selection	5325355
29943317	29943339	6	+	27760321	HT29	viability after 10 days	GCGCTTCCTCCGCGGGTACCGG	HLA-A	ENSG00000206503	0.1376842016671067	[1068,833]	[1260,1415,1247]	1	hSpCas9	negative selection	5325356
29943335	29943357	6	-	27760321	HT29	viability after 10 days	GCCGTCGTAGGCGTCCTGCCGG	HLA-A	ENSG00000206503	-0.3767039130971134	[541,422]	[466,464,459]	-5	hSpCas9	negative selection	5325357
29943286	29943308	6	+	27760321	MOLM13	viability	TAATGTATGGCTGCGACGTGGG	HLA-A	ENSG00000206503	-2.2351033834404372	[637,602]	[34,107]	-8	hSpCas9	negative selection	5408818
29943317	29943339	6	+	27760321	MOLM13	viability	GCGCTTCCTCCGCGGGTACCGG	HLA-A	ENSG00000206503	1.252535746533045	[1085,1068]	[2033,956]	8	hSpCas9	negative selection	5408819
29943335	29943357	6	-	27760321	MOLM13	viability	GCCGTCGTAGGCGTCCTGCCGG	HLA-A	ENSG00000206503	-2.2297640974869632	[626,541]	[81,59]	-8	hSpCas9	negative selection	5408820
29943323	29943346	6	-	27260156	BXPC3	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.3311949827596513	[405]	[454,530,340,849]	7	hSpCas9	negative selection	5547733
29943333	29943356	6	+	27260156	BXPC3	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.0015711680146699436	[568]	[527,648,523,685]	0	hSpCas9	negative selection	5547734
29944386	29944409	6	-	27260156	BXPC3	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.6945582612203933	[1759]	[1013,986,1131,1470]	-8	hSpCas9	negative selection	5611995
29944147	29944170	6	+	27260156	BXPC3	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.7477853731572346	[694]	[303,569,407,453]	-9	hSpCas9	negative selection	5611996
29943323	29943346	6	-	27260156	A673	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.49216098475166603	[405]	[839,599,721,593]	9	hSpCas9	negative selection	5668984
29943333	29943356	6	+	27260156	A673	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.13711562860813353	[568]	[623,591,671,594]	-3	hSpCas9	negative selection	5668985
29944386	29944409	6	-	27260156	A673	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.4156902637365636	[1759]	[1816,1398,1414,1744]	-7	hSpCas9	negative selection	5733246
29944147	29944170	6	+	27260156	A673	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.2821214564424284	[694]	[646,721,745,618]	-6	hSpCas9	negative selection	5733247
29943323	29943346	6	-	27260156	A375	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.7339396121820895	[405]	[733,902,656,863]	9	hSpCas9	negative selection	5790235
29943333	29943356	6	+	27260156	A375	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.0247322929339035	[568]	[703,675,671,571]	0	hSpCas9	negative selection	5790236
29944386	29944409	6	-	27260156	A375	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.8300643480629648	[1759]	[1633,1084,1160,779]	-8	hSpCas9	negative selection	5854497
29944147	29944170	6	+	27260156	A375	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-1.1242349504261981	[694]	[454,325,381,324]	-8	hSpCas9	negative selection	5854498
29943323	29943346	6	-	27260156	COLO741	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.09857969302511105	[405]	[512,487,652]	2	hSpCas9	negative selection	5911486
29943333	29943356	6	+	27260156	COLO741	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.29181782393676703	[568]	[759,564,477]	-6	hSpCas9	negative selection	5911487
29944386	29944409	6	-	27260156	COLO741	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.5192625373873703	[1759]	[1412,1810,1473]	-8	hSpCas9	negative selection	5975748
29944147	29944170	6	+	27260156	COLO741	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.1859980744948349	[694]	[784,838,720]	-4	hSpCas9	negative selection	5975749
29943323	29943346	6	-	27260156	CAL120	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.4992149120700975	[405]	[1022,591,575]	7	hSpCas9	negative selection	6032737
29943333	29943356	6	+	27260156	CAL120	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.9171851957191361	[568]	[451,349,334]	-8	hSpCas9	negative selection	6032738
29944386	29944409	6	-	27260156	CAL120	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.6199223300521521	[1759]	[1508,1777,1007]	-7	hSpCas9	negative selection	6096999
29944147	29944170	6	+	27260156	CAL120	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.3365642542217657	[694]	[905,682,501]	-5	hSpCas9	negative selection	6097000
29943323	29943346	6	-	27260156	CADOES1	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.5739867747117557	[405]	[648,477,432,692]	8	hSpCas9	negative selection	6153988
29943333	29943356	6	+	27260156	CADOES1	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.12445239015971946	[568]	[378,526,504,532]	-2	hSpCas9	negative selection	6153989
29944386	29944409	6	-	27260156	CADOES1	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.7744872960715576	[1759]	[811,961,1123,928]	-8	hSpCas9	negative selection	6218250
29944147	29944170	6	+	27260156	CADOES1	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.6379717138690233	[694]	[468,404,406,378]	-8	hSpCas9	negative selection	6218251
29943323	29943346	6	-	27260156	EWS502	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.178010894019783	[405]	[360,522,576,498]	3	hSpCas9	negative selection	6275239
29943333	29943356	6	+	27260156	EWS502	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.20089839275853807	[568]	[598,366,566,562]	-4	hSpCas9	negative selection	6275240
29944386	29944409	6	-	27260156	EWS502	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-1.0424758381598458	[1759]	[716,778,1012,1154]	-9	hSpCas9	negative selection	6339501
29944147	29944170	6	+	27260156	EWS502	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.9894994054187825	[694]	[258,476,367,387]	-8	hSpCas9	negative selection	6339502
29943323	29943346	6	-	27260156	EW8	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.6683408321470568	[405]	[765,432,383,556]	9	hSpCas9	negative selection	6396490
29943333	29943356	6	+	27260156	EW8	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.003162759441472651	[568]	[551,521,472,308]	0	hSpCas9	negative selection	6396491
29944386	29944409	6	-	27260156	EW8	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.5634213578516476	[1759]	[1083,1000,794,1019]	-8	hSpCas9	negative selection	6460752
29944147	29944170	6	+	27260156	EW8	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.3100841329106841	[694]	[724,431,329,379]	-5	hSpCas9	negative selection	6460753
29943323	29943346	6	-	27260156	CORL105	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.3037724036137816	[405]	[640,452,725,552]	5	hSpCas9	negative selection	6517741
29943333	29943356	6	+	27260156	CORL105	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.4225174774464848	[568]	[462,321,682,550]	-6	hSpCas9	negative selection	6517742
29944386	29944409	6	-	27260156	CORL105	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.4073104202743607	[1759]	[1633,1291,1759,1567]	-6	hSpCas9	negative selection	6582003
29944147	29944170	6	+	27260156	CORL105	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.5183914042928393	[694]	[448,563,777,509]	-7	hSpCas9	negative selection	6582004
29943323	29943346	6	-	27260156	HS294T	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.4960307314237402	[405]	[182,240,266,191]	6	hSpCas9	negative selection	6638992
29943333	29943356	6	+	27260156	HS294T	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.46050844165891747	[568]	[275,434,253,230]	6	hSpCas9	negative selection	6638993
29944386	29944409	6	-	27260156	HS294T	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.5774310196843058	[1759]	[297,331,467,801]	-7	hSpCas9	negative selection	6703254
29944147	29944170	6	+	27260156	HS294T	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.3913810382590462	[694]	[208,134,215,271]	-5	hSpCas9	negative selection	6703255
29943323	29943346	6	-	27260156	HCC44	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.6120283237836344	[405]	[927,726,634,522]	8	hSpCas9	negative selection	6760243
29943333	29943356	6	+	27260156	HCC44	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.3084661846784702	[568]	[1034,524,1007,712]	5	hSpCas9	negative selection	6760244
29944386	29944409	6	-	27260156	HCC44	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.8356826800593251	[1759]	[1532,1195,952,779]	-8	hSpCas9	negative selection	6824505
29944147	29944170	6	+	27260156	HCC44	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.9980517294897233	[694]	[251,286,552,504]	-8	hSpCas9	negative selection	6824506
29943323	29943346	6	-	27260156	G402	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.33164555390779626	[405]	[1105,390,479,572]	4	hSpCas9	negative selection	6881494
29943333	29943356	6	+	27260156	G402	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.33542187884559616	[568]	[1388,904,629,662]	4	hSpCas9	negative selection	6881495
29944386	29944409	6	-	27260156	G402	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-1.0674881650969705	[1759]	[1206,780,818,1286]	-8	hSpCas9	negative selection	6945756
29944147	29944170	6	+	27260156	G402	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-1.0347159111007604	[694]	[508,185,150,789]	-8	hSpCas9	negative selection	6945757
29943323	29943346	6	-	27260156	L33	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.47419437149164234	[405]	[637,189,388,533]	8	hSpCas9	negative selection	7002745
29943333	29943356	6	+	27260156	L33	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.1513409880591196	[568]	[693,301,338,555]	3	hSpCas9	negative selection	7002746
29944386	29944409	6	-	27260156	L33	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.05088502322148325	[1759]	[1654,654,1093,1801]	-1	hSpCas9	negative selection	7067007
29944147	29944170	6	+	27260156	L33	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	0.02704359980714688	[694]	[711,301,454,659]	0	hSpCas9	negative selection	7067008
29943323	29943346	6	-	27260156	K562	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	-0.4073296217827923	[405]	[464,267,245,137]	-5	hSpCas9	negative selection	7123996
29943333	29943356	6	+	27260156	K562	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.6628465559927359	[568]	[459,442,235,170]	-7	hSpCas9	negative selection	7123997
29944386	29944409	6	-	27260156	K562	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-1.5304958636452102	[1759]	[412,340,661,703]	-9	hSpCas9	negative selection	7188258
29944147	29944170	6	+	27260156	K562	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-1.2852025086130254	[694]	[332,178,89,394]	-8	hSpCas9	negative selection	7188259
29943323	29943346	6	-	27260156	HT29	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.5422888201733954	[405]	[867,604,747,657]	9	hSpCas9	negative selection	7245247
29943333	29943356	6	+	27260156	HT29	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.06190263984537833	[568]	[641,771,724,530]	-1	hSpCas9	negative selection	7245248
29944386	29944409	6	-	27260156	HT29	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.6772609000565846	[1759]	[1759,1396,1131,1117]	-8	hSpCas9	negative selection	7309509
29944147	29944170	6	+	27260156	HT29	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.7222380384878027	[694]	[625,584,419,437]	-8	hSpCas9	negative selection	7309510
29943323	29943346	6	-	27260156	MHHES1	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.34137052290786396	[405]	[719,614,619,409]	6	hSpCas9	negative selection	7366498
29943333	29943356	6	+	27260156	MHHES1	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.3764545383519223	[568]	[497,380,464,585]	-6	hSpCas9	negative selection	7366499
29944386	29944409	6	-	27260156	MHHES1	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.6502051863520439	[1759]	[1337,1473,1313,991]	-8	hSpCas9	negative selection	7430760
29944147	29944170	6	+	27260156	MHHES1	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.9520058932189679	[694]	[503,427,459,264]	-9	hSpCas9	negative selection	7430761
29943323	29943346	6	-	27260156	MEWO	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.26893224189237813	[405]	[438,313,616]	6	hSpCas9	negative selection	7487749
29943333	29943356	6	+	27260156	MEWO	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.04485007168458138	[568]	[637,440,492]	-1	hSpCas9	negative selection	7487750
29944386	29944409	6	-	27260156	MEWO	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.3996596131023513	[1759]	[1547,1111,1142]	-7	hSpCas9	negative selection	7552011
29944147	29944170	6	+	27260156	MEWO	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.11883753594653279	[694]	[661,499,646]	-3	hSpCas9	negative selection	7552012
29943323	29943346	6	-	27260156	LNCAPCLONEFGC	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.2761163936475064	[405]	[353,402,588,460]	4	hSpCas9	negative selection	7609000
29943333	29943356	6	+	27260156	LNCAPCLONEFGC	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.061419258047365755	[568]	[726,413,513,496]	0	hSpCas9	negative selection	7609001
29944386	29944409	6	-	27260156	LNCAPCLONEFGC	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.9266281701467564	[1759]	[788,717,1078,812]	-8	hSpCas9	negative selection	7673262
29944147	29944170	6	+	27260156	LNCAPCLONEFGC	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-1.2436731065326059	[694]	[299,181,284,303]	-9	hSpCas9	negative selection	7673263
29943323	29943346	6	-	27260156	PANC0327	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.7148171122411111	[405]	[1010,392,297,724]	8	hSpCas9	negative selection	7730251
29943333	29943356	6	+	27260156	PANC0327	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.12513469737622124	[568]	[734,364,593,549]	1	hSpCas9	negative selection	7730252
29944386	29944409	6	-	27260156	PANC0327	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.6892175366033833	[1759]	[769,1221,841,994]	-7	hSpCas9	negative selection	7794513
29944147	29944170	6	+	27260156	PANC0327	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.8074893896951153	[694]	[297,208,424,492]	-8	hSpCas9	negative selection	7794514
29943323	29943346	6	-	27260156	NCIH2009	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.4561953474930728	[405]	[804,646,888]	6	hSpCas9	negative selection	7851502
29943333	29943356	6	+	27260156	NCIH2009	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.34770859783918795	[568]	[1163,1084,812]	5	hSpCas9	negative selection	7851503
29944386	29944409	6	-	27260156	NCIH2009	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-1.0574708676846067	[1759]	[1639,909,1087]	-8	hSpCas9	negative selection	7915764
29944147	29944170	6	+	27260156	NCIH2009	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-1.7122997651972094	[694]	[478,273,171]	-9	hSpCas9	negative selection	7915765
29943323	29943346	6	-	27260156	NCIH1373	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.7651740345198674	[405]	[430,552,1288,203]	7	hSpCas9	negative selection	7972753
29943333	29943356	6	+	27260156	NCIH1373	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.5737504737367554	[568]	[1340,691,1163,173]	5	hSpCas9	negative selection	7972754
29944386	29944409	6	-	27260156	NCIH1373	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.956382134362445	[1759]	[1027,685,1574,205]	-7	hSpCas9	negative selection	8037015
29944147	29944170	6	+	27260156	NCIH1373	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-2.002404167428384	[694]	[265,147,177,52]	-9	hSpCas9	negative selection	8037016
29943323	29943346	6	-	27260156	PATU8902	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	1.2963291897291078	[405]	[1429,2474,500,1368]	9	hSpCas9	negative selection	8094004
29943333	29943356	6	+	27260156	PATU8902	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	1.030644082524708	[568]	[1398,1406,1581,2149]	9	hSpCas9	negative selection	8094005
29944386	29944409	6	-	27260156	PATU8902	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-2.264965409731958	[1759]	[450,760,467,348]	-9	hSpCas9	negative selection	8158266
29944147	29944170	6	+	27260156	PATU8902	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-2.636062000118108	[694]	[274,228,45,90]	-9	hSpCas9	negative selection	8158267
29943323	29943346	6	-	27260156	PANC1	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.46379790011628963	[405]	[611,536,426,366]	7	hSpCas9	negative selection	8215255
29943333	29943356	6	+	27260156	PANC1	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.008694824630087195	[568]	[478,717,514,301]	0	hSpCas9	negative selection	8215256
29944386	29944409	6	-	27260156	PANC1	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.986552324109758	[1759]	[664,1059,607,766]	-8	hSpCas9	negative selection	8279517
29944147	29944170	6	+	27260156	PANC1	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-1.1554712420475952	[694]	[358,226,245,230]	-8	hSpCas9	negative selection	8279518
29943323	29943346	6	-	27260156	PANC0813	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.596910510391359	[405]	[756,725,834,577]	8	hSpCas9	negative selection	8336506
29943333	29943356	6	+	27260156	PANC0813	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.1942661179410638	[568]	[967,876,707,535]	3	hSpCas9	negative selection	8336507
29944386	29944409	6	-	27260156	PANC0813	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-1.0255769676247901	[1759]	[1231,869,1215,776]	-8	hSpCas9	negative selection	8400768
29944147	29944170	6	+	27260156	PANC0813	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.748203873086325	[694]	[593,458,637,274]	-8	hSpCas9	negative selection	8400769
29943323	29943346	6	-	27260156	RDES	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.6825774959516917	[405]	[524,813,740,971]	9	hSpCas9	negative selection	8457757
29943333	29943356	6	+	27260156	RDES	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.07974841401929844	[568]	[538,582,787,917]	1	hSpCas9	negative selection	8457758
29944386	29944409	6	-	27260156	RDES	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-1.2081812289954938	[1759]	[713,839,1086,883]	-9	hSpCas9	negative selection	8522019
29944147	29944170	6	+	27260156	RDES	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.9629325043876836	[694]	[388,403,407,433]	-9	hSpCas9	negative selection	8522020
29943323	29943346	6	-	27260156	PC3	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.30043850274595885	[405]	[287,386,755,726]	6	hSpCas9	negative selection	8579008
29943333	29943356	6	+	27260156	PC3	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.36483326247632564	[568]	[275,460,905,322]	-7	hSpCas9	negative selection	8579009
29944386	29944409	6	-	27260156	PC3	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.21658064648996356	[1759]	[780,1781,2638,1451]	-5	hSpCas9	negative selection	8643270
29944147	29944170	6	+	27260156	PC3	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.2969281334240394	[694]	[427,495,897,561]	-6	hSpCas9	negative selection	8643271
29943323	29943346	6	-	27260156	PATU8988T	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.2703509285171377	[405]	[560,387,528,399]	4	hSpCas9	negative selection	8700259
29943333	29943356	6	+	27260156	PATU8988T	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.6656776016922074	[568]	[150,293,215,754]	-8	hSpCas9	negative selection	8700260
29944386	29944409	6	-	27260156	PATU8988T	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.886146829891882	[1759]	[750,997,1001,936]	-8	hSpCas9	negative selection	8764521
29944147	29944170	6	+	27260156	PATU8988T	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.7609206105779311	[694]	[461,285,511,305]	-8	hSpCas9	negative selection	8764522
29943323	29943346	6	-	27260156	T47D	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	-0.11893791872891549	[405]	[451,357,417,523]	-3	hSpCas9	negative selection	8821510
29943333	29943356	6	+	27260156	T47D	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.3147849252013751	[568]	[580,450,537,569]	-6	hSpCas9	negative selection	8821511
29944386	29944409	6	-	27260156	T47D	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.9390279679086216	[1759]	[1231,1020,1042,983]	-9	hSpCas9	negative selection	8885772
29944147	29944170	6	+	27260156	T47D	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-1.1061239141254215	[694]	[384,308,423,391]	-9	hSpCas9	negative selection	8885773
29943323	29943346	6	-	27260156	SU8686	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	-0.005994826298892447	[405]	[343,453,375,429]	0	hSpCas9	negative selection	8942761
29943333	29943356	6	+	27260156	SU8686	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.4910504568844206	[568]	[489,271,356,505]	-7	hSpCas9	negative selection	8942762
29944386	29944409	6	-	27260156	SU8686	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-1.048259664873669	[1759]	[659,863,937,943]	-8	hSpCas9	negative selection	9007023
29944147	29944170	6	+	27260156	SU8686	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-1.2849528871803946	[694]	[244,309,229,354]	-9	hSpCas9	negative selection	9007024
29943323	29943346	6	-	27260156	SKES1	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.2611211676258588	[405]	[578,495,424,454]	5	hSpCas9	negative selection	9064012
29943333	29943356	6	+	27260156	SKES1	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.2063481909692116	[568]	[420,648,548,366]	-4	hSpCas9	negative selection	9064013
29944386	29944409	6	-	27260156	SKES1	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.6771910213236731	[1759]	[1432,1013,1066,923]	-9	hSpCas9	negative selection	9128274
29944147	29944170	6	+	27260156	SKES1	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.2604073703355109	[694]	[632,569,564,550]	-5	hSpCas9	negative selection	9128275
29943323	29943346	6	-	27260156	TOV112D	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.07068921462939037	[405]	[321,650,434,347]	1	hSpCas9	negative selection	9185263
29943333	29943356	6	+	27260156	TOV112D	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.3934806051402367	[568]	[604,428,392,323]	-7	hSpCas9	negative selection	9185264
29944386	29944409	6	-	27260156	TOV112D	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.29591790688997777	[1759]	[1392,2237,1274,1039]	-5	hSpCas9	negative selection	9249525
29944147	29944170	6	+	27260156	TOV112D	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.40067916884579324	[694]	[767,616,397,371]	-7	hSpCas9	negative selection	9249526
29943323	29943346	6	-	27260156	TC71	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.41386029689020065	[405]	[595,520,495,716]	8	hSpCas9	negative selection	9306514
29943333	29943356	6	+	27260156	TC71	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	-0.10365025397091351	[568]	[499,619,449,714]	-3	hSpCas9	negative selection	9306515
29944386	29944409	6	-	27260156	TC71	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.1753423414377986	[1759]	[1605,1609,1833,1625]	-4	hSpCas9	negative selection	9370776
29944147	29944170	6	+	27260156	TC71	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.15904898207325757	[694]	[678,652,614,726]	-4	hSpCas9	negative selection	9370777
29943323	29943346	6	-	27260156	TC32	viability	CGTCCTGCCGGTACCCGCGGAGG	HLA-A	ENSG00000206503	0.36015451261364273	[405]	[475,341,577,613]	6	hSpCas9	negative selection	9427765
29943333	29943356	6	+	27260156	TC32	viability	TACCGGCAGGACGCCTACGACGG	HLA-A	ENSG00000206503	0.02814595578022394	[568]	[620,471,584,488]	0	hSpCas9	negative selection	9427766
29944386	29944409	6	-	27260156	TC32	viability	TCCCTCCTTACCCCATCTCAGGG	HLA-A	ENSG00000206503	-0.5715923229455719	[1759]	[1155,968,1148,1163]	-8	hSpCas9	negative selection	9492027
29944147	29944170	6	+	27260156	TC32	viability	CCACCCCATCTCTGACCATGAGG	HLA-A	ENSG00000206503	-0.6585580728888306	[694]	[407,284,568,446]	-8	hSpCas9	negative selection	9492028
29943338	29943361	6	+	28162770	P31FUJ	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	0.48795316257056864	[357]	[589]	5	hSpCas9	negative selection	10169705
29943290	29943313	6	+	28162770	P31FUJ	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	0.24277683679951584	[209]	[291]	2	hSpCas9	negative selection	10169706
29943380	29943403	6	+	28162770	P31FUJ	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-2.759348018910213	[362]	[62]	-9	hSpCas9	negative selection	10169707
29943522	29943545	6	+	28162770	P31FUJ	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	-0.11361284920434654	[208]	[226]	-1	hSpCas9	negative selection	10169708
29943338	29943361	6	+	28162770	TF1	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	NaN	[NaN]	[182]	1	hSpCas9	negative selection	10339071
29943290	29943313	6	+	28162770	TF1	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	NaN	[NaN]	[128]	1	hSpCas9	negative selection	10339072
29943380	29943403	6	+	28162770	TF1	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	NaN	[NaN]	[30]	1	hSpCas9	negative selection	10339073
29943522	29943545	6	+	28162770	TF1	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	NaN	[NaN]	[88]	1	hSpCas9	negative selection	10339074
29943338	29943361	6	+	28162770	SKM1	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	-0.11839470080223019	[69]	[113]	-1	hSpCas9	negative selection	10508437
29943290	29943313	6	+	28162770	SKM1	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	0.5757578098250027	[62]	[165]	5	hSpCas9	negative selection	10508438
29943380	29943403	6	+	28162770	SKM1	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-3.5661627935924156	[66]	[9]	-9	hSpCas9	negative selection	10508439
29943522	29943545	6	+	28162770	SKM1	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	0.2904730312364071	[36]	[79]	3	hSpCas9	negative selection	10508440
29943338	29943361	6	+	28162770	SKM1	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	-0.11839470080223019	[69]	[113]	-1	hSpCas9	negative selection	10677803
29943290	29943313	6	+	28162770	SKM1	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	0.5757578098250027	[62]	[165]	5	hSpCas9	negative selection	10677804
29943380	29943403	6	+	28162770	SKM1	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-3.5661627935924156	[66]	[9]	-9	hSpCas9	negative selection	10677805
29943522	29943545	6	+	28162770	SKM1	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	0.2904730312364071	[36]	[79]	3	hSpCas9	negative selection	10677806
29943338	29943361	6	+	28162770	PL21	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	0.05439798104055982	[280]	[126]	0	hSpCas9	negative selection	10847169
29943290	29943313	6	+	28162770	PL21	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	-0.2058527451865167	[264]	[99]	-1	hSpCas9	negative selection	10847170
29943380	29943403	6	+	28162770	PL21	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-1.5680447102876065	[217]	[31]	-7	hSpCas9	negative selection	10847171
29943522	29943545	6	+	28162770	PL21	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	-0.27018032029071337	[132]	[47]	-2	hSpCas9	negative selection	10847172
29943338	29943361	6	+	28162770	P31FUJ	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	0.48795316257056864	[357]	[589]	5	hSpCas9	negative selection	11016535
29943290	29943313	6	+	28162770	P31FUJ	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	0.24277683679951584	[209]	[291]	2	hSpCas9	negative selection	11016536
29943380	29943403	6	+	28162770	P31FUJ	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-2.759348018910213	[362]	[62]	-9	hSpCas9	negative selection	11016537
29943522	29943545	6	+	28162770	P31FUJ	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	-0.11361284920434654	[208]	[226]	-1	hSpCas9	negative selection	11016538
29943338	29943361	6	+	28162770	OCIAML5	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	0.14077363756313677	[201]	[401]	1	hSpCas9	negative selection	11185901
29943290	29943313	6	+	28162770	OCIAML5	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	1.263410646555939	[110]	[480]	9	hSpCas9	negative selection	11185902
29943380	29943403	6	+	28162770	OCIAML5	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-3.1739946657513594	[129]	[25]	-9	hSpCas9	negative selection	11185903
29943522	29943545	6	+	28162770	OCIAML5	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	0.7230481439008121	[97]	[291]	6	hSpCas9	negative selection	11185904
29943338	29943361	6	+	28162770	EOL1	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	0.730887068777403	[405]	[354]	6	hSpCas9	negative selection	11355267
29943290	29943313	6	+	28162770	EOL1	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	0.7005829304153331	[305]	[261]	6	hSpCas9	negative selection	11355268
29943380	29943403	6	+	28162770	EOL1	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-0.9591281104622335	[261]	[70]	-6	hSpCas9	negative selection	11355269
29943522	29943545	6	+	28162770	EOL1	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	-1.1117940754931859	[200]	[48]	-6	hSpCas9	negative selection	11355270
29943338	29943361	6	+	28162770	MOLM13	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	-2.2311448858853726	[512]	[78]	-7	hSpCas9	negative selection	11524633
29943290	29943313	6	+	28162770	MOLM13	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	0.9552715219224943	[315]	[442]	7	hSpCas9	negative selection	11524634
29943380	29943403	6	+	28162770	MOLM13	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-5.112055044409953	[286]	[5]	-9	hSpCas9	negative selection	11524635
29943522	29943545	6	+	28162770	MOLM13	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	-2.15454782459524	[233]	[37]	-7	hSpCas9	negative selection	11524636
29943338	29943361	6	+	28162770	HEL	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	-0.009893495258605056	[370]	[235]	0	hSpCas9	negative selection	11693999
29943290	29943313	6	+	28162770	HEL	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	0.8313708474361294	[314]	[358]	7	hSpCas9	negative selection	11694000
29943380	29943403	6	+	28162770	HEL	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-1.6001176918958064	[212]	[44]	-7	hSpCas9	negative selection	11694001
29943522	29943545	6	+	28162770	HEL	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	-0.7005629136795725	[169]	[66]	-4	hSpCas9	negative selection	11694002
29943338	29943361	6	+	28162770	MV411	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	0.2622853151900888	[289]	[292]	2	hSpCas9	negative selection	11863365
29943290	29943313	6	+	28162770	MV411	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	-0.11967931787084246	[226]	[175]	-1	hSpCas9	negative selection	11863366
29943380	29943403	6	+	28162770	MV411	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-2.4599215812981075	[208]	[31]	-8	hSpCas9	negative selection	11863367
29943522	29943545	6	+	28162770	MV411	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	-0.7764091911715923	[121]	[59]	-5	hSpCas9	negative selection	11863368
29943338	29943361	6	+	28162770	MONOMAC1	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	0.2736684744039225	[196]	[272]	2	hSpCas9	negative selection	12032731
29943290	29943313	6	+	28162770	MONOMAC1	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	-0.3125140644794898	[155]	[143]	-3	hSpCas9	negative selection	12032732
29943380	29943403	6	+	28162770	MONOMAC1	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-1.8491135436392472	[131]	[41]	-8	hSpCas9	negative selection	12032733
29943522	29943545	6	+	28162770	MONOMAC1	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	0.5922841521677888	[91]	[158]	6	hSpCas9	negative selection	12032734
29943338	29943361	6	+	28162770	OCIAML2	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	0.00026090877020013004	[56]	[315]	0	hSpCas9	negative selection	12202097
29943290	29943313	6	+	28162770	OCIAML2	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	0.5447454006447545	[34]	[282]	5	hSpCas9	negative selection	12202098
29943380	29943403	6	+	28162770	OCIAML2	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-2.434103949217047	[38]	[39]	-8	hSpCas9	negative selection	12202099
29943522	29943545	6	+	28162770	OCIAML2	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	-1.114486015016886	[24]	[63]	-6	hSpCas9	negative selection	12202100
29943338	29943361	6	+	28162770	OCIAML3	viability	GCAGGACGCCTACGACGGCAAGG	HLA-A	ENSG00000206503	0.9336216853310415	[76]	[443]	7	hSpCas9	negative selection	12371463
29943290	29943313	6	+	28162770	OCIAML3	viability	GTATGGCTGCGACGTGGGGTCGG	HLA-A	ENSG00000206503	0.3475756734505149	[62]	[241]	3	hSpCas9	negative selection	12371464
29943380	29943403	6	+	28162770	OCIAML3	viability	GGACCTGCGCTCTTGGACCGCGG	HLA-A	ENSG00000206503	-1.5665269039020562	[51]	[52]	-8	hSpCas9	negative selection	12371465
29943522	29943545	6	+	28162770	OCIAML3	viability	AAGGAGACGCTGCAGCGCACGGG	HLA-A	ENSG00000206503	-0.1566023280168649	[23]	[64]	-1	hSpCas9	negative selection	12371466