Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:64843
• Symbol:ISL2
• Description:ISL LIM homeobox 2

DataSource: http://genomecrispr.dkfz.de/#!/results/ISL2

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
76338264	76338287	15	+	26472758	Jiyoye	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	0.5384199147841261	[146]	[160]	4	hSpCas9	negative selection	79422
76338348	76338371	15	-	26472758	Jiyoye	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	2.8324812162385444	[34]	[187]	9	hSpCas9	negative selection	79423
76337871	76337894	15	-	26472758	Jiyoye	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	-0.0522562371314238	[153]	[111]	0	hSpCas9	negative selection	79424
76338264	76338287	15	+	26472758	KBM7	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	0.6210808905677779	[727,621]	[399,563]	6	hSpCas9	negative selection	270540
76338348	76338371	15	-	26472758	KBM7	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	0.9678857311208273	[282,252]	[61,410]	9	hSpCas9	negative selection	270541
76337871	76337894	15	-	26472758	KBM7	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.5533926697765655	[785,811]	[546,561]	6	hSpCas9	negative selection	270542
76338264	76338287	15	+	26472758	Raji	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	-0.0469446110176944	[275]	[61]	0	hSpCas9	negative selection	461658
76338348	76338371	15	-	26472758	Raji	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	-0.534162493713924	[155]	[24]	-4	hSpCas9	negative selection	461659
76337871	76337894	15	-	26472758	Raji	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.3435302519525818	[342]	[100]	3	hSpCas9	negative selection	461660
76338264	76338287	15	+	26472758	K562	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	0.7188409626478782	[469]	[652]	6	hSpCas9	negative selection	652776
76338348	76338371	15	-	26472758	K562	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	1.3655105445838087	[216]	[471]	9	hSpCas9	negative selection	652777
76337871	76337894	15	-	26472758	K562	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.053350882898405505	[652]	[571]	0	hSpCas9	negative selection	652778
76337793	76337816	15	-	26627737	DLD1	viability	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	0.5812219994708272	[2481]	[1421,1258,852]	6	hSpCas9	negative selection	791877
76337827	76337850	15	-	26627737	DLD1	viability	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.8567040509217674	[645]	[341,220,505]	8	hSpCas9	negative selection	791878
76338303	76338326	15	-	26627737	DLD1	viability	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.5432683362948969	[434]	[202,307,102]	5	hSpCas9	negative selection	791879
76337793	76337816	15	-	26627737	GBM cells	viability after 5 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	-0.46452903109766375	[1180]	[410,506]	-6	hSpCas9	negative selection	874192
76337827	76337850	15	-	26627737	GBM cells	viability after 5 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.22013632288155816	[408]	[231,278]	3	hSpCas9	negative selection	874193
76338303	76338326	15	-	26627737	GBM cells	viability after 5 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.18901652391765011	[219]	[103,164]	3	hSpCas9	negative selection	874194
76337793	76337816	15	-	26627737	GBM cells	viability after 13 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	-0.22635509053611003	[1180]	[646,466]	-3	hSpCas9	negative selection	956507
76337827	76337850	15	-	26627737	GBM cells	viability after 13 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.435247634783302	[408]	[277,317]	5	hSpCas9	negative selection	956508
76338303	76338326	15	-	26627737	GBM cells	viability after 13 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.02188426460046075	[219]	[86,148]	0	hSpCas9	negative selection	956509
76337793	76337816	15	-	26627737	GBM cells	viability after 21 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	-0.43404624984678963	[1180]	[476,472]	-4	hSpCas9	negative selection	1038822
76337827	76337850	15	-	26627737	GBM cells	viability after 21 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.36493207275241535	[408]	[305,267]	4	hSpCas9	negative selection	1038823
76338303	76338326	15	-	26627737	GBM cells	viability after 21 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	-0.17033552478697825	[219]	[112,99]	-1	hSpCas9	negative selection	1038824
76337793	76337816	15	-	26627737	RPE1	viability after 9 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	-0.24892687966163285	[4203]	[952,1306]	-2	hSpCas9	negative selection	1121137
76337827	76337850	15	-	26627737	RPE1	viability after 9 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	1.0162594445719364	[1016]	[705,563]	6	hSpCas9	negative selection	1121138
76338303	76338326	15	-	26627737	RPE1	viability after 9 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.22414330545383482	[778]	[97,525]	1	hSpCas9	negative selection	1121139
76337793	76337816	15	-	26627737	RPE1	viability after 12 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	-0.508959580365252	[4203]	[664,929]	-4	hSpCas9	negative selection	1203452
76337827	76337850	15	-	26627737	RPE1	viability after 12 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.8574586980524344	[1016]	[360,636]	5	hSpCas9	negative selection	1203453
76338303	76338326	15	-	26627737	RPE1	viability after 12 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	-0.24269437939033536	[778]	[87,270]	-2	hSpCas9	negative selection	1203454
76337793	76337816	15	-	26627737	RPE1	viability after 15 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	-0.42058480863696834	[4203]	[888,887]	-3	hSpCas9	negative selection	1285767
76337827	76337850	15	-	26627737	RPE1	viability after 15 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.613012041738004	[1016]	[467,412]	4	hSpCas9	negative selection	1285768
76338303	76338326	15	-	26627737	RPE1	viability after 15 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.2282681295985696	[778]	[165,346]	1	hSpCas9	negative selection	1285769
76337793	76337816	15	-	26627737	RPE1	viability after 18 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	-0.814585541722435	[4203]	[675,611]	-5	hSpCas9	negative selection	1368082
76337827	76337850	15	-	26627737	RPE1	viability after 18 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.4442083325423977	[1016]	[268,484]	3	hSpCas9	negative selection	1368083
76338303	76338326	15	-	26627737	RPE1	viability after 18 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.0481955726234093	[778]	[96,345]	0	hSpCas9	negative selection	1368084
76337793	76337816	15	-	26627737	HeLa	viability after 8 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	-0.09566320338722467	[1632]	[718,728,565]	-1	hSpCas9	negative selection	1450397
76337827	76337850	15	-	26627737	HeLa	viability after 8 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.20903524967670606	[616]	[569,223,201]	2	hSpCas9	negative selection	1450398
76338303	76338326	15	-	26627737	HeLa	viability after 8 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.18348689750424066	[367]	[244,214,104]	1	hSpCas9	negative selection	1450399
76337793	76337816	15	-	26627737	HeLa	viability after 12 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	0.37727661757620234	[1632]	[1182,721,749]	3	hSpCas9	negative selection	1532712
76337827	76337850	15	-	26627737	HeLa	viability after 12 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.06555081746914937	[616]	[290,249,261]	0	hSpCas9	negative selection	1532713
76338303	76338326	15	-	26627737	HeLa	viability after 12 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	-0.0448615496843649	[367]	[21,209,199]	0	hSpCas9	negative selection	1532714
76337793	76337816	15	-	26627737	HeLa	viability after 15 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	-0.24638895629794222	[1632]	[497,346,859]	-2	hSpCas9	negative selection	1615027
76337827	76337850	15	-	26627737	HeLa	viability after 15 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.37255891886285764	[616]	[269,287,425]	3	hSpCas9	negative selection	1615028
76338303	76338326	15	-	26627737	HeLa	viability after 15 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.510712078028311	[367]	[205,177,259]	4	hSpCas9	negative selection	1615029
76337793	76337816	15	-	26627737	HeLa	viability after 18 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	-0.252226227265661	[1632]	[329,286,859]	-2	hSpCas9	negative selection	1697342
76337827	76337850	15	-	26627737	HeLa	viability after 18 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.34134594024143483	[616]	[171,232,425]	3	hSpCas9	negative selection	1697343
76338303	76338326	15	-	26627737	HeLa	viability after 18 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.46578501970369135	[367]	[128,142,259]	4	hSpCas9	negative selection	1697344
76337793	76337816	15	-	26627737	HCT116	viability after 6 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	0.8676240854407502	[2543]	[1071,540]	5	hSpCas9	negative selection	1779657
76337827	76337850	15	-	26627737	HCT116	viability after 6 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	-0.48727223427132604	[1118]	[236,63]	-3	hSpCas9	negative selection	1779658
76338303	76338326	15	-	26627737	HCT116	viability after 6 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	1.187428415140372	[608]	[500,61]	6	hSpCas9	negative selection	1779659
76337793	76337816	15	-	26627737	HCT116	viability after 8 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	0.18600712801358	[1187]	[895,611,728]	2	hSpCas9	negative selection	1861972
76337827	76337850	15	-	26627737	HCT116	viability after 8 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.7374440680933159	[391]	[383,270,424]	7	hSpCas9	negative selection	1861973
76338303	76338326	15	-	26627737	HCT116	viability after 8 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.32435630153876477	[336]	[313,235,149]	3	hSpCas9	negative selection	1861974
76337793	76337816	15	-	26627737	HCT116	viability after 9 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	0.660691493460186	[2543]	[1203,970]	5	hSpCas9	negative selection	1944287
76337827	76337850	15	-	26627737	HCT116	viability after 9 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	-0.7626131859211189	[1118]	[174,176]	-5	hSpCas9	negative selection	1944288
76338303	76338326	15	-	26627737	HCT116	viability after 9 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.03676037438892123	[608]	[77,236]	0	hSpCas9	negative selection	1944289
76337793	76337816	15	-	26627737	HCT116	viability after 12 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	0.3604227897509287	[1187]	[899,723,769]	3	hSpCas9	negative selection	2026602
76337827	76337850	15	-	26627737	HCT116	viability after 12 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.02600075417835085	[391]	[211,165,249]	0	hSpCas9	negative selection	2026603
76338303	76338326	15	-	26627737	HCT116	viability after 12 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.3196415669329091	[336]	[244,221,193]	3	hSpCas9	negative selection	2026604
76337793	76337816	15	-	26627737	HCT116	viability after 15 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	0.312619815158105	[1187]	[1237,622,729]	3	hSpCas9	negative selection	2108917
76337827	76337850	15	-	26627737	HCT116	viability after 15 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.7301270697678219	[391]	[433,264,427]	6	hSpCas9	negative selection	2108918
76338303	76338326	15	-	26627737	HCT116	viability after 15 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	-0.030568489973703428	[336]	[221,210,139]	0	hSpCas9	negative selection	2108919
76337793	76337816	15	-	26627737	HCT116	viability after 18 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	0.6151055723815302	[1187]	[1129,794,711]	5	hSpCas9	negative selection	2191232
76337827	76337850	15	-	26627737	HCT116	viability after 18 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.5199907705567361	[391]	[265,301,243]	4	hSpCas9	negative selection	2191233
76338303	76338326	15	-	26627737	HCT116	viability after 18 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.007487026466973301	[336]	[205,131,154]	0	hSpCas9	negative selection	2191234
76337770	76337793	15	+	24336569	HL60	viability	CCCGGCAGAGAAGCCCGGGACGG	ISL2	ENSG00000159556	-0.4699524673745607	[340]	[520]	-4	hSpCas9	negative selection	2272291
76337782	76337805	15	+	24336569	HL60	viability	GCCCGGGACGGCCATGTGCGTGG	ISL2	ENSG00000159556	-0.43491870107020225	[878]	[1375]	-4	hSpCas9	negative selection	2272292
76337789	76337812	15	+	24336569	HL60	viability	ACGGCCATGTGCGTGGGCTGCGG	ISL2	ENSG00000159556	0.23654628637673009	[589]	[1470]	2	hSpCas9	negative selection	2272293
76337820	76337843	15	+	24336569	HL60	viability	TCCACGACCAGTTTATCCTGCGG	ISL2	ENSG00000159556	2.3714761907875426	[80]	[886]	9	hSpCas9	negative selection	2272294
76337827	76337850	15	-	24336569	HL60	viability	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	-0.1318820076151196	[494]	[955]	-1	hSpCas9	negative selection	2272295
76337836	76337859	15	-	24336569	HL60	viability	CGAGGTCGGGCGACACCCGCAGG	ISL2	ENSG00000159556	0.442872041140759	[323]	[931]	4	hSpCas9	negative selection	2272296
76337841	76337864	15	+	24336569	HL60	viability	GGGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	-0.7501484272475554	[336]	[423]	-6	hSpCas9	negative selection	2272297
76337848	76337871	15	+	24336569	HL60	viability	GCCCGACCTCGAGTGGCACGCGG	ISL2	ENSG00000159556	0.4545887996113135	[729]	[2116]	4	hSpCas9	negative selection	2272298
76337854	76337877	15	-	24336569	HL60	viability	GGCAGGCCGCGTGCCACTCGAGG	ISL2	ENSG00000159556	0.7000908663245533	[805]	[2770]	6	hSpCas9	negative selection	2272299
76337871	76337894	15	-	24336569	HL60	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	1.0437152047404434	[170]	[745]	7	hSpCas9	negative selection	2272300
76337770	76337793	15	+	24336569	KBM7	viability	CCCGGCAGAGAAGCCCGGGACGG	ISL2	ENSG00000159556	1.2222722017587866	[153]	[979]	8	hSpCas9	negative selection	2339468
76337782	76337805	15	+	24336569	KBM7	viability	GCCCGGGACGGCCATGTGCGTGG	ISL2	ENSG00000159556	0.6348389246607801	[454]	[1926]	6	hSpCas9	negative selection	2339469
76337789	76337812	15	+	24336569	KBM7	viability	ACGGCCATGTGCGTGGGCTGCGG	ISL2	ENSG00000159556	-0.19292068499835813	[618]	[1476]	-2	hSpCas9	negative selection	2339470
76337820	76337843	15	+	24336569	KBM7	viability	TCCACGACCAGTTTATCCTGCGG	ISL2	ENSG00000159556	0.04222607113193377	[187]	[527]	0	hSpCas9	negative selection	2339471
76337827	76337850	15	-	24336569	KBM7	viability	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	1.4104017985786896	[303]	[2203]	9	hSpCas9	negative selection	2339472
76337836	76337859	15	-	24336569	KBM7	viability	CGAGGTCGGGCGACACCCGCAGG	ISL2	ENSG00000159556	-0.07729827550055646	[310]	[803]	0	hSpCas9	negative selection	2339473
76337841	76337864	15	+	24336569	KBM7	viability	GGGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	-1.417269362391624	[470]	[480]	-7	hSpCas9	negative selection	2339474
76337848	76337871	15	+	24336569	KBM7	viability	GCCCGACCTCGAGTGGCACGCGG	ISL2	ENSG00000159556	0.06575362719124367	[639]	[1826]	0	hSpCas9	negative selection	2339475
76337854	76337877	15	-	24336569	KBM7	viability	GGCAGGCCGCGTGCCACTCGAGG	ISL2	ENSG00000159556	-1.0264175948393024	[763]	[1022]	-6	hSpCas9	negative selection	2339476
76337871	76337894	15	-	24336569	KBM7	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	1.0875227896455488	[156]	[909]	8	hSpCas9	negative selection	2339477
76336714	76336737	15	-	25494202	A375	resistance to PLX-4720 (puromycin)	AACACGCACTAGCCCCGGGCCGG	ISL2	ENSG00000159556	6.693751034092447	[21,101]	[2447,338]	9	dCas9-VP64	positive selection	2466441
76336714	76336737	15	-	25494202	A375	resistance to PLX-4720 (zeocin)	AACACGCACTAGCCCCGGGCCGG	ISL2	ENSG00000159556	0.1467749365217605	[140,39]	[19,43]	1	dCas9-VP64	positive selection	2561696
76337821	76337844	15	-	27260157	DLD1	viability	CCCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	-0.630326864727752	[]	[]	-5	hSpCas9	negative selection	2576932
76337770	76337793	15	+	27260157	DLD1	viability	CCCGGCAGAGAAGCCCGGGACGG	ISL2	ENSG00000159556	0.79423228170402	[]	[]	9	hSpCas9	negative selection	2577676
76337793	76337816	15	-	27260157	DLD1	viability	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	0.333923046831506	[]	[]	4	hSpCas9	negative selection	2580535
76337836	76337859	15	-	27260157	DLD1	viability	CGAGGTCGGGCGACACCCGCAGG	ISL2	ENSG00000159556	-1.19641153989791	[]	[]	-7	hSpCas9	negative selection	2580994
76337841	76337864	15	+	27260157	DLD1	viability	GGGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	0.450802494314447	[]	[]	7	hSpCas9	negative selection	2582787
76337849	76337872	15	-	27260157	DLD1	viability	GCCGCGTGCCACTCGAGGTCGGG	ISL2	ENSG00000159556	0.77867928368832	[]	[]	8	hSpCas9	negative selection	2583580
76337848	76337871	15	+	27260157	DLD1	viability	GCCCGACCTCGAGTGGCACGCGG	ISL2	ENSG00000159556	0.603166158569388	[]	[]	8	hSpCas9	negative selection	2605182
76337820	76337843	15	+	27260157	DLD1	viability	TCCACGACCAGTTTATCCTGCGG	ISL2	ENSG00000159556	0.163282135938974	[]	[]	3	hSpCas9	negative selection	2606680
76337915	76337938	15	+	27260157	DLD1	viability	TGCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	-0.440531601620997	[]	[]	-4	hSpCas9	negative selection	2606776
76337871	76337894	15	-	27260157	DLD1	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.208189146744196	[]	[]	3	hSpCas9	negative selection	2606989
76337783	76337806	15	+	27260157	DLD1	viability	CCCGGGACGGCCATGTGCGTGGG	ISL2	ENSG00000159556	-1.66127774013932	[]	[]	-8	hSpCas9	negative selection	2606992
76337827	76337850	15	-	27260157	DLD1	viability	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	-0.729401648714825	[]	[]	-5	hSpCas9	negative selection	2612829
76337943	76337966	15	-	27260157	DLD1	viability	GACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	-1.17983359609619	[]	[]	-7	hSpCas9	negative selection	2619083
76337782	76337805	15	+	27260157	DLD1	viability	GCCCGGGACGGCCATGTGCGTGG	ISL2	ENSG00000159556	-0.839028566534167	[]	[]	-6	hSpCas9	negative selection	2621715
76337896	76337919	15	-	27260157	DLD1	viability	TGCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	-1.16188411567941	[]	[]	-7	hSpCas9	negative selection	2621978
76337789	76337812	15	+	27260157	DLD1	viability	ACGGCCATGTGCGTGGGCTGCGG	ISL2	ENSG00000159556	-1.0440727879565	[]	[]	-7	hSpCas9	negative selection	2621986
76337783	76337806	15	-	27260157	DLD1	viability	CCCACGCACATGGCCGTCCCGGG	ISL2	ENSG00000159556	0.81088516315584	[]	[]	9	hSpCas9	negative selection	2640874
76338303	76338326	15	-	27260157	DLD1	viability	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	-0.888673139354946	[]	[]	-6	hSpCas9	negative selection	2642247
76337854	76337877	15	-	27260157	DLD1	viability	GGCAGGCCGCGTGCCACTCGAGG	ISL2	ENSG00000159556	0.610492437473065	[]	[]	8	hSpCas9	negative selection	2645321
76337821	76337844	15	-	27260157	HT1080	viability	CCCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	0.347060336861164	[]	[]	3	hSpCas9	negative selection	2653062
76337770	76337793	15	+	27260157	HT1080	viability	CCCGGCAGAGAAGCCCGGGACGG	ISL2	ENSG00000159556	0.778601954141687	[]	[]	6	hSpCas9	negative selection	2653806
76337793	76337816	15	-	27260157	HT1080	viability	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	0.0187641785964844	[]	[]	0	hSpCas9	negative selection	2656665
76337836	76337859	15	-	27260157	HT1080	viability	CGAGGTCGGGCGACACCCGCAGG	ISL2	ENSG00000159556	-0.556539030312453	[]	[]	-7	hSpCas9	negative selection	2657124
76337841	76337864	15	+	27260157	HT1080	viability	GGGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	-0.36876214670339	[]	[]	-7	hSpCas9	negative selection	2658917
76337849	76337872	15	-	27260157	HT1080	viability	GCCGCGTGCCACTCGAGGTCGGG	ISL2	ENSG00000159556	0.608302525957384	[]	[]	5	hSpCas9	negative selection	2659710
76337848	76337871	15	+	27260157	HT1080	viability	GCCCGACCTCGAGTGGCACGCGG	ISL2	ENSG00000159556	0.830877910907738	[]	[]	7	hSpCas9	negative selection	2681312
76337820	76337843	15	+	27260157	HT1080	viability	TCCACGACCAGTTTATCCTGCGG	ISL2	ENSG00000159556	0.34532611015366	[]	[]	3	hSpCas9	negative selection	2682810
76337915	76337938	15	+	27260157	HT1080	viability	TGCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	0.776660930515166	[]	[]	6	hSpCas9	negative selection	2682906
76337871	76337894	15	-	27260157	HT1080	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.562092211164845	[]	[]	5	hSpCas9	negative selection	2683119
76337783	76337806	15	+	27260157	HT1080	viability	CCCGGGACGGCCATGTGCGTGGG	ISL2	ENSG00000159556	0.501979684902846	[]	[]	4	hSpCas9	negative selection	2683122
76337827	76337850	15	-	27260157	HT1080	viability	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.741371444042189	[]	[]	6	hSpCas9	negative selection	2688959
76337943	76337966	15	-	27260157	HT1080	viability	GACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	0.906334981222309	[]	[]	7	hSpCas9	negative selection	2695213
76337782	76337805	15	+	27260157	HT1080	viability	GCCCGGGACGGCCATGTGCGTGG	ISL2	ENSG00000159556	-0.214243065084974	[]	[]	0	hSpCas9	negative selection	2697845
76337896	76337919	15	-	27260157	HT1080	viability	TGCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	-0.122922871353146	[]	[]	0	hSpCas9	negative selection	2698108
76337789	76337812	15	+	27260157	HT1080	viability	ACGGCCATGTGCGTGGGCTGCGG	ISL2	ENSG00000159556	-0.830410066717859	[]	[]	-8	hSpCas9	negative selection	2698116
76337783	76337806	15	-	27260157	HT1080	viability	CCCACGCACATGGCCGTCCCGGG	ISL2	ENSG00000159556	-0.278905685490576	[]	[]	-4	hSpCas9	negative selection	2717004
76338303	76338326	15	-	27260157	HT1080	viability	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	-0.483398645260705	[]	[]	-7	hSpCas9	negative selection	2718377
76337854	76337877	15	-	27260157	HT1080	viability	GGCAGGCCGCGTGCCACTCGAGG	ISL2	ENSG00000159556	0.905511790565855	[]	[]	7	hSpCas9	negative selection	2721451
76337821	76337844	15	-	27260157	MKN45	viability	CCCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	0.425123218099732	[]	[]	6	hSpCas9	negative selection	2729192
76337770	76337793	15	+	27260157	MKN45	viability	CCCGGCAGAGAAGCCCGGGACGG	ISL2	ENSG00000159556	1.10717038876017	[]	[]	8	hSpCas9	negative selection	2729936
76337793	76337816	15	-	27260157	MKN45	viability	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	0.474060729664723	[]	[]	6	hSpCas9	negative selection	2732795
76337836	76337859	15	-	27260157	MKN45	viability	CGAGGTCGGGCGACACCCGCAGG	ISL2	ENSG00000159556	-0.285280360379959	[]	[]	-1	hSpCas9	negative selection	2733254
76337841	76337864	15	+	27260157	MKN45	viability	GGGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	-0.0802866538885012	[]	[]	0	hSpCas9	negative selection	2735047
76337849	76337872	15	-	27260157	MKN45	viability	GCCGCGTGCCACTCGAGGTCGGG	ISL2	ENSG00000159556	-0.760205680834964	[]	[]	-7	hSpCas9	negative selection	2735840
76337848	76337871	15	+	27260157	MKN45	viability	GCCCGACCTCGAGTGGCACGCGG	ISL2	ENSG00000159556	1.08645974785196	[]	[]	8	hSpCas9	negative selection	2757442
76337820	76337843	15	+	27260157	MKN45	viability	TCCACGACCAGTTTATCCTGCGG	ISL2	ENSG00000159556	-0.328556075116121	[]	[]	-1	hSpCas9	negative selection	2758940
76337915	76337938	15	+	27260157	MKN45	viability	TGCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	0.674803668514225	[]	[]	7	hSpCas9	negative selection	2759036
76337871	76337894	15	-	27260157	MKN45	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	-0.288523427838918	[]	[]	-1	hSpCas9	negative selection	2759249
76337783	76337806	15	+	27260157	MKN45	viability	CCCGGGACGGCCATGTGCGTGGG	ISL2	ENSG00000159556	-0.503971490822259	[]	[]	-6	hSpCas9	negative selection	2759252
76337827	76337850	15	-	27260157	MKN45	viability	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.17891650892292	[]	[]	5	hSpCas9	negative selection	2765089
76337943	76337966	15	-	27260157	MKN45	viability	GACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	0.477831653229877	[]	[]	6	hSpCas9	negative selection	2771343
76337782	76337805	15	+	27260157	MKN45	viability	GCCCGGGACGGCCATGTGCGTGG	ISL2	ENSG00000159556	-2.26398015845062	[]	[]	-9	hSpCas9	negative selection	2773975
76337896	76337919	15	-	27260157	MKN45	viability	TGCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	0.232061774445235	[]	[]	5	hSpCas9	negative selection	2774238
76337789	76337812	15	+	27260157	MKN45	viability	ACGGCCATGTGCGTGGGCTGCGG	ISL2	ENSG00000159556	-0.516762337788926	[]	[]	-6	hSpCas9	negative selection	2774246
76337783	76337806	15	-	27260157	MKN45	viability	CCCACGCACATGGCCGTCCCGGG	ISL2	ENSG00000159556	0.123195436275692	[]	[]	4	hSpCas9	negative selection	2793134
76338303	76338326	15	-	27260157	MKN45	viability	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.193372554441142	[]	[]	5	hSpCas9	negative selection	2794507
76337854	76337877	15	-	27260157	MKN45	viability	GGCAGGCCGCGTGCCACTCGAGG	ISL2	ENSG00000159556	0.674074169769485	[]	[]	7	hSpCas9	negative selection	2797581
76337821	76337844	15	-	27260157	RKO	viability	CCCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	-0.487366384674194	[]	[]	-6	hSpCas9	negative selection	2805322
76337770	76337793	15	+	27260157	RKO	viability	CCCGGCAGAGAAGCCCGGGACGG	ISL2	ENSG00000159556	1.25759424791412	[]	[]	9	hSpCas9	negative selection	2806066
76337793	76337816	15	-	27260157	RKO	viability	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	0.549384225537263	[]	[]	3	hSpCas9	negative selection	2808925
76337836	76337859	15	-	27260157	RKO	viability	CGAGGTCGGGCGACACCCGCAGG	ISL2	ENSG00000159556	-0.228770761443423	[]	[]	-1	hSpCas9	negative selection	2809384
76337841	76337864	15	+	27260157	RKO	viability	GGGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	-0.061791714510819	[]	[]	0	hSpCas9	negative selection	2811177
76337849	76337872	15	-	27260157	RKO	viability	GCCGCGTGCCACTCGAGGTCGGG	ISL2	ENSG00000159556	-0.561154363677116	[]	[]	-7	hSpCas9	negative selection	2811970
76337848	76337871	15	+	27260157	RKO	viability	GCCCGACCTCGAGTGGCACGCGG	ISL2	ENSG00000159556	0.29167947749348	[]	[]	1	hSpCas9	negative selection	2833572
76337820	76337843	15	+	27260157	RKO	viability	TCCACGACCAGTTTATCCTGCGG	ISL2	ENSG00000159556	0.148447061993294	[]	[]	0	hSpCas9	negative selection	2835070
76337915	76337938	15	+	27260157	RKO	viability	TGCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	-0.253635318859284	[]	[]	-1	hSpCas9	negative selection	2835166
76337871	76337894	15	-	27260157	RKO	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.493267997322288	[]	[]	2	hSpCas9	negative selection	2835379
76337783	76337806	15	+	27260157	RKO	viability	CCCGGGACGGCCATGTGCGTGGG	ISL2	ENSG00000159556	0.0386151515922293	[]	[]	0	hSpCas9	negative selection	2835382
76337827	76337850	15	-	27260157	RKO	viability	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.1671005640632	[]	[]	0	hSpCas9	negative selection	2841219
76337943	76337966	15	-	27260157	RKO	viability	GACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	-0.913895049534645	[]	[]	-8	hSpCas9	negative selection	2847473
76337782	76337805	15	+	27260157	RKO	viability	GCCCGGGACGGCCATGTGCGTGG	ISL2	ENSG00000159556	-1.18080126490104	[]	[]	-8	hSpCas9	negative selection	2850105
76337896	76337919	15	-	27260157	RKO	viability	TGCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	-1.11526912539605	[]	[]	-8	hSpCas9	negative selection	2850368
76337789	76337812	15	+	27260157	RKO	viability	ACGGCCATGTGCGTGGGCTGCGG	ISL2	ENSG00000159556	-0.290310050500024	[]	[]	-6	hSpCas9	negative selection	2850376
76337783	76337806	15	-	27260157	RKO	viability	CCCACGCACATGGCCGTCCCGGG	ISL2	ENSG00000159556	0.535448221242583	[]	[]	3	hSpCas9	negative selection	2869264
76338303	76338326	15	-	27260157	RKO	viability	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.58143074537813	[]	[]	3	hSpCas9	negative selection	2870637
76337854	76337877	15	-	27260157	RKO	viability	GGCAGGCCGCGTGCCACTCGAGG	ISL2	ENSG00000159556	0.634008167535421	[]	[]	3	hSpCas9	negative selection	2873711
76337821	76337844	15	-	27260157	SF268	viability	CCCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	0.0971503127290762	[]	[]	0	hSpCas9	negative selection	2881452
76337770	76337793	15	+	27260157	SF268	viability	CCCGGCAGAGAAGCCCGGGACGG	ISL2	ENSG00000159556	0.824649672391758	[]	[]	8	hSpCas9	negative selection	2882196
76337793	76337816	15	-	27260157	SF268	viability	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	1.24840422510015	[]	[]	9	hSpCas9	negative selection	2885055
76337836	76337859	15	-	27260157	SF268	viability	CGAGGTCGGGCGACACCCGCAGG	ISL2	ENSG00000159556	-0.0260029802205507	[]	[]	0	hSpCas9	negative selection	2885514
76337841	76337864	15	+	27260157	SF268	viability	GGGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	-0.0429141049323028	[]	[]	0	hSpCas9	negative selection	2887307
76337849	76337872	15	-	27260157	SF268	viability	GCCGCGTGCCACTCGAGGTCGGG	ISL2	ENSG00000159556	0.274153210846833	[]	[]	4	hSpCas9	negative selection	2888100
76337848	76337871	15	+	27260157	SF268	viability	GCCCGACCTCGAGTGGCACGCGG	ISL2	ENSG00000159556	0.312824428381253	[]	[]	4	hSpCas9	negative selection	2909702
76337820	76337843	15	+	27260157	SF268	viability	TCCACGACCAGTTTATCCTGCGG	ISL2	ENSG00000159556	0.665315478339639	[]	[]	8	hSpCas9	negative selection	2911200
76337915	76337938	15	+	27260157	SF268	viability	TGCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	0.258898286674342	[]	[]	4	hSpCas9	negative selection	2911296
76337871	76337894	15	-	27260157	SF268	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	-0.0827012420304957	[]	[]	0	hSpCas9	negative selection	2911509
76337783	76337806	15	+	27260157	SF268	viability	CCCGGGACGGCCATGTGCGTGGG	ISL2	ENSG00000159556	0.39897215297302	[]	[]	4	hSpCas9	negative selection	2911512
76337827	76337850	15	-	27260157	SF268	viability	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	-0.772753413316299	[]	[]	-6	hSpCas9	negative selection	2917349
76337943	76337966	15	-	27260157	SF268	viability	GACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	-0.0448378735189711	[]	[]	0	hSpCas9	negative selection	2923603
76337782	76337805	15	+	27260157	SF268	viability	GCCCGGGACGGCCATGTGCGTGG	ISL2	ENSG00000159556	-0.676257894221515	[]	[]	-5	hSpCas9	negative selection	2926235
76337896	76337919	15	-	27260157	SF268	viability	TGCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	-0.278892010345385	[]	[]	-2	hSpCas9	negative selection	2926498
76337789	76337812	15	+	27260157	SF268	viability	ACGGCCATGTGCGTGGGCTGCGG	ISL2	ENSG00000159556	-0.932517680774544	[]	[]	-6	hSpCas9	negative selection	2926506
76337783	76337806	15	-	27260157	SF268	viability	CCCACGCACATGGCCGTCCCGGG	ISL2	ENSG00000159556	0.170012925795251	[]	[]	0	hSpCas9	negative selection	2945394
76338303	76338326	15	-	27260157	SF268	viability	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.0242381798067111	[]	[]	0	hSpCas9	negative selection	2946767
76337854	76337877	15	-	27260157	SF268	viability	GGCAGGCCGCGTGCCACTCGAGG	ISL2	ENSG00000159556	-0.483412736678941	[]	[]	-4	hSpCas9	negative selection	2949841
76338436	76338459	15	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	-1.1598733443653344	[2,2]	[0,0]	-9	hSpCas9	positive selection	2996047
76338420	76338443	15	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCAGGAGGCCGTGGTCGGCGCGG	ISL2	ENSG00000159556	-0.34372619321552284	[2,2]	[3,0]	-5	hSpCas9	positive selection	2996048
76338348	76338371	15	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	-0.09430323878254843	[2,1]	[1,1]	-1	hSpCas9	positive selection	2996049
76338495	76338518	15	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TACCGGGCAGATGCAGGCCGCGG	ISL2	ENSG00000159556	-0.4863508371702898	[2,3]	[3,0]	-6	hSpCas9	positive selection	2996050
76338436	76338459	15	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.4976675678851872	[2,2]	[1,4]	8	hSpCas9	positive selection	3063905
76338420	76338443	15	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCAGGAGGCCGTGGTCGGCGCGG	ISL2	ENSG00000159556	-0.4907447848252974	[2,2]	[1,0]	-7	hSpCas9	positive selection	3063906
76338348	76338371	15	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	-1.1966651255449081	[2,2]	[0,0]	-9	hSpCas9	positive selection	3063907
76338495	76338518	15	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TACCGGGCAGATGCAGGCCGCGG	ISL2	ENSG00000159556	0.074128117843661	[2,2]	[3,1]	1	hSpCas9	positive selection	3063908
76337848	76337871		+	24336571	A375	resistance to PLX after 7 days	GCCCGACCTCGAGTGGCACGCGG	ISL2	ENSG00000159556	-0.18614112977053746	[16,16]	[13,14]	-6	hSpCas9	positive selection	3121661
76337850	76337873		-	24336571	A375	resistance to PLX after 7 days	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.2909276341380731	[13,10]	[9,9]	-8	hSpCas9	positive selection	3121662
76336895	76336918		+	24336571	A375	resistance to PLX after 7 days	TATTTTTCATTATCCTTTTCTGG	ISL2	ENSG00000159556	-0.06446405951978412	[15,13]	[14,12]	-2	hSpCas9	positive selection	3121664
76336908	76336931		-	24336571	A375	resistance to PLX after 7 days	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.37136118507000493	[3,3]	[2,2]	-9	hSpCas9	positive selection	3121665
76337848	76337871		+	24336571	A375	resistance to PLX after 14 days	GCCCGACCTCGAGTGGCACGCGG	ISL2	ENSG00000159556	-0.26798355686073894	[10,10]	[4,2]	-3	hSpCas9	positive selection	3179454
76337850	76337873		-	24336571	A375	resistance to PLX after 14 days	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.5889371803297854	[11,11]	[3,2]	-7	hSpCas9	positive selection	3179455
76336895	76336918		+	24336571	A375	resistance to PLX after 14 days	TATTTTTCATTATCCTTTTCTGG	ISL2	ENSG00000159556	-0.046002612767820666	[8,14]	[5,4]	0	hSpCas9	positive selection	3179457
76336908	76336931		-	24336571	A375	resistance to PLX after 14 days	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	0.3640003904856821	[3,2]	[1,1]	3	hSpCas9	positive selection	3179458
76337848	76337871		+	24336571	A375	viability after 7 days	GCCCGACCTCGAGTGGCACGCGG	ISL2	ENSG00000159556	0.28588412752574316	[13]	[16,16]	4	hSpCas9	negative selection	3237247
76337850	76337873		-	24336571	A375	viability after 7 days	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	0.23856339933709098	[10]	[13,10]	3	hSpCas9	negative selection	3237248
76336895	76336918		+	24336571	A375	viability after 7 days	TATTTTTCATTATCCTTTTCTGG	ISL2	ENSG00000159556	-0.34368647977886135	[19]	[15,13]	-5	hSpCas9	negative selection	3237250
76336908	76336931		-	24336571	A375	viability after 7 days	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.8563505170586404	[7]	[3,3]	-8	hSpCas9	negative selection	3237251
76337848	76337871		+	24336571	A375	viability after 14 days	GCCCGACCTCGAGTGGCACGCGG	ISL2	ENSG00000159556	-0.26626627593475505	[13]	[10,10]	-3	hSpCas9	negative selection	3295040
76337850	76337873		-	24336571	A375	viability after 14 days	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	0.21086520140601658	[10]	[11,11]	2	hSpCas9	negative selection	3295041
76336895	76336918		+	24336571	A375	viability after 14 days	TATTTTTCATTATCCTTTTCTGG	ISL2	ENSG00000159556	-0.6137108580763551	[19]	[8,14]	-6	hSpCas9	negative selection	3295043
76336908	76336931		-	24336571	A375	viability after 14 days	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.9949403618904095	[7]	[3,2]	-8	hSpCas9	negative selection	3295044
76338379	76338402	15	-	27383988	293T	resistance to West Nile virus (flavivirus)	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.028076007416413237	[155,155]	[0,0]	0	hSpCas9	positive selection	3374694
76336908	76336931	15	-	27383988	293T	resistance to West Nile virus (flavivirus)	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	2.169863370195496	[33,33]	[0,0]	7	hSpCas9	positive selection	3374695
76337850	76337873	15	-	27383988	293T	resistance to West Nile virus (flavivirus)	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.5628527509693527	[225,225]	[0,0]	-4	hSpCas9	positive selection	3374696
76338435	76338458	15	+	26780180	HT29	viability (Avana library 4 designs)	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	1.29711676966975	[]	[]	5	hSpCas9	negative selection	3433436
76338420	76338443	15	-	26780180	HT29	viability (Avana library 4 designs)	GCAGGAGGCCGTGGTCGGCGCGG	ISL2	ENSG00000159556	1.42219234699365	[]	[]	5	hSpCas9	negative selection	3433437
76338348	76338371	15	-	26780180	HT29	viability (Avana library 4 designs)	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	2.20752990031247	[]	[]	7	hSpCas9	negative selection	3433438
76338495	76338518	15	-	26780180	HT29	viability (Avana library 4 designs)	TACCGGGCAGATGCAGGCCGCGG	ISL2	ENSG00000159556	1.60364690397381	[]	[]	6	hSpCas9	negative selection	3433439
76338435	76338458	15	+	26780180	A375	viability (Avana lentiCRISPRv2)	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	3.784332176807	[]	[]	6	hSpCas9	negative selection	3520048
76338420	76338443	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCAGGAGGCCGTGGTCGGCGCGG	ISL2	ENSG00000159556	2.3467345413506	[]	[]	3	hSpCas9	negative selection	3520049
76338495	76338518	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	TACCGGGCAGATGCAGGCCGCGG	ISL2	ENSG00000159556	4.8862462605793	[]	[]	8	hSpCas9	negative selection	3520050
76338348	76338371	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	4.36621409086433	[]	[]	7	hSpCas9	negative selection	3520051
76337943	76337966	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	GACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	1.42876128290718	[]	[]	2	hSpCas9	negative selection	3520052
76337871	76337894	15	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	6.40159121246314	[]	[]	9	hSpCas9	negative selection	3520053
76338435	76338458	15	+	26780180	A375	viability (Avana lentiGuide)	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	6.12140838399705	[]	[]	5	hSpCas9	negative selection	3628707
76338420	76338443	15	-	26780180	A375	viability (Avana lentiGuide)	GCAGGAGGCCGTGGTCGGCGCGG	ISL2	ENSG00000159556	7.76385399873125	[]	[]	6	hSpCas9	negative selection	3628708
76338495	76338518	15	-	26780180	A375	viability (Avana lentiGuide)	TACCGGGCAGATGCAGGCCGCGG	ISL2	ENSG00000159556	0.114817153438059	[]	[]	0	hSpCas9	negative selection	3628709
76338348	76338371	15	-	26780180	A375	viability (Avana lentiGuide)	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	-0.081487539312153	[]	[]	0	hSpCas9	negative selection	3628710
76337943	76337966	15	-	26780180	A375	viability (Avana lentiGuide)	GACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	-0.56644721154003	[]	[]	-1	hSpCas9	negative selection	3628711
76337871	76337894	15	-	26780180	A375	viability (Avana lentiGuide)	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	9.67388318135187	[]	[]	6	hSpCas9	negative selection	3628712
76338435	76338458	15	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.13541620164717583	[4]	[5,3]	3	hSpCas9	positive selection	3737366
76338420	76338443	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAGGAGGCCGTGGTCGGCGCGG	ISL2	ENSG00000159556	0.3966969106014192	[4]	[4,6]	9	hSpCas9	positive selection	3737367
76338495	76338518	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TACCGGGCAGATGCAGGCCGCGG	ISL2	ENSG00000159556	0.19446578193610914	[4]	[5,4]	5	hSpCas9	positive selection	3737368
76338348	76338371	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	0.4617876320611073	[3]	[4,5]	9	hSpCas9	positive selection	3737369
76337943	76337966	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	0.3457592526993034	[4]	[6,5]	9	hSpCas9	positive selection	3737370
76337871	76337894	15	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.3694668092272976	[4]	[6,5]	9	hSpCas9	positive selection	3737371
76338435	76338458	15	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	-0.2822131942170075	[5]	[2,4]	-4	hSpCas9	positive selection	3845973
76338420	76338443	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAGGAGGCCGTGGTCGGCGCGG	ISL2	ENSG00000159556	-0.9172117283163588	[5]	[2,0]	-8	hSpCas9	positive selection	3845974
76338495	76338518	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TACCGGGCAGATGCAGGCCGCGG	ISL2	ENSG00000159556	0.31062180144537477	[5]	[6,5]	8	hSpCas9	positive selection	3845975
76338348	76338371	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	0.35243540962084047	[3]	[3,4]	9	hSpCas9	positive selection	3845976
76337943	76337966	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	0.24147833463486762	[5]	[6,5]	6	hSpCas9	positive selection	3845977
76337871	76337894	15	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	-0.3010504296676135	[5]	[4,2]	-4	hSpCas9	positive selection	3845978
76337946	76337969	15	+	26780180	A375	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.758909963210153	[]	[]	3	hSpCas9	negative selection	3951990
76337902	76337925	15	-	26780180	A375	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	1.3559152812822	[]	[]	7	hSpCas9	negative selection	3951991
76338435	76338458	15	+	26780180	A375	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.498767803639479	[]	[]	1	hSpCas9	negative selection	3951992
76338379	76338402	15	-	26780180	A375	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	1.68302657126304	[]	[]	9	hSpCas9	negative selection	3951993
76337850	76337873	15	-	26780180	A375	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	1.58653535308707	[]	[]	8	hSpCas9	negative selection	3951994
76336908	76336931	15	-	26780180	A375	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	0.924312542826457	[]	[]	4	hSpCas9	negative selection	3951995
76337946	76337969	15	+	26780180	HT29	viability (GeCKOv2 library)	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.732897193993952	[]	[]	3	hSpCas9	negative selection	4059956
76337902	76337925	15	-	26780180	HT29	viability (GeCKOv2 library)	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	2.07546847278318	[]	[]	9	hSpCas9	negative selection	4059957
76338435	76338458	15	+	26780180	HT29	viability (GeCKOv2 library)	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.773343997798714	[]	[]	3	hSpCas9	negative selection	4059958
76338379	76338402	15	-	26780180	HT29	viability (GeCKOv2 library)	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	1.94422153081176	[]	[]	9	hSpCas9	negative selection	4059959
76337850	76337873	15	-	26780180	HT29	viability (GeCKOv2 library)	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	1.47290440151118	[]	[]	7	hSpCas9	negative selection	4059960
76336908	76336931	15	-	26780180	HT29	viability (GeCKOv2 library)	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	1.53984773597746	[]	[]	7	hSpCas9	negative selection	4059961
76337848	76337871	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCCCGACCTCGAGTGGCACGCGG	ISL2	ENSG00000159556	0.0615984606996839	[3]	[2,1]	1	hSpCas9	positive selection	4145365
76337850	76337873	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	0.012816457883724262	[3]	[3,1]	0	hSpCas9	positive selection	4145366
76336895	76336918	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TATTTTTCATTATCCTTTTCTGG	ISL2	ENSG00000159556	-0.02634289816359703	[3]	[1,2]	0	hSpCas9	positive selection	4145368
76336908	76336931	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.27921420455774537	[2]	[1,0]	-6	hSpCas9	positive selection	4145369
76337848	76337871	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCCCGACCTCGAGTGGCACGCGG	ISL2	ENSG00000159556	0.6657453533675497	[3]	[4,3,3,0]	4	hSpCas9	positive selection	4209387
76337850	76337873	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	0.8983699639657375	[3]	[1,2,0,3]	6	hSpCas9	positive selection	4209388
76336895	76336918	15	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TATTTTTCATTATCCTTTTCTGG	ISL2	ENSG00000159556	-0.07217184699640888	[4]	[3,3,0,0]	-1	hSpCas9	positive selection	4209390
76336908	76336931	15	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	0.6027368345709097	[2]	[0,2,4,0]	4	hSpCas9	positive selection	4209391
76337902	76337925	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.34603814433085733	[3]	[2,1]	-6	hSpCas9	positive selection	4277346
76337946	76337969	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.5929682373945574	[3]	[4,4]	9	hSpCas9	positive selection	4277347
76338435	76338458	15	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.02257038279061535	[2]	[2,1]	0	hSpCas9	positive selection	4277348
76338379	76338402	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	0.04134914529603039	[3]	[2,2]	0	hSpCas9	positive selection	4341602
76336908	76336931	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.3490278852689762	[2]	[0,0]	-6	hSpCas9	positive selection	4341603
76337850	76337873	15	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.410351903134663	[3]	[2,0]	-7	hSpCas9	positive selection	4341604
76337821	76337843	15	-	27760321	OCIAML3	viability	CCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	-0.25606802050869304	[584,401]	[281,367]	-3	hSpCas9	negative selection	4410401
76337842	76337864	15	+	27760321	OCIAML3	viability	GGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	0.11736124351747829	[401,375]	[314,349]	1	hSpCas9	negative selection	4410402
76337896	76337918	15	-	27760321	OCIAML3	viability	GCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	0.3447624067445244	[888,697]	[587,1036]	4	hSpCas9	negative selection	4410403
76337916	76337938	15	+	27760321	OCIAML3	viability	GCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	-0.0759508887662455	[455,361]	[242,377]	-1	hSpCas9	negative selection	4410404
76337943	76337965	15	-	27760321	OCIAML3	viability	ACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	-0.24258427341480415	[570,477]	[307,393]	-3	hSpCas9	negative selection	4410405
76337821	76337843	15	-	27760321	OCIAML2	viability	CCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	0.7668508683441706	[584,401]	[580,789]	9	hSpCas9	negative selection	4493864
76337842	76337864	15	+	27760321	OCIAML2	viability	GGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	0.6285132024143378	[401,375]	[396,604]	8	hSpCas9	negative selection	4493865
76337896	76337918	15	-	27760321	OCIAML2	viability	GCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	-0.008185607282107155	[888,697]	[602,674]	0	hSpCas9	negative selection	4493866
76337916	76337938	15	+	27760321	OCIAML2	viability	GCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	0.12480067943661145	[455,361]	[320,407]	1	hSpCas9	negative selection	4493867
76337943	76337965	15	-	27760321	OCIAML2	viability	ACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	0.07623783408208967	[570,477]	[366,548]	1	hSpCas9	negative selection	4493868
76337821	76337843	15	-	27760321	MV411	viability	CCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	0.653958841475015	[584,401]	[391,677]	5	hSpCas9	negative selection	4577327
76337842	76337864	15	+	27760321	MV411	viability	GGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	-1.1488520192810863	[401,375]	[152,59]	-6	hSpCas9	negative selection	4577328
76337896	76337918	15	-	27760321	MV411	viability	GCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	0.3840294791513593	[888,697]	[705,637]	2	hSpCas9	negative selection	4577329
76337916	76337938	15	+	27760321	MV411	viability	GCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	1.2096008157964173	[455,361]	[99,1401]	8	hSpCas9	negative selection	4577330
76337943	76337965	15	-	27760321	MV411	viability	ACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	1.5650880298007244	[570,477]	[1089,914]	9	hSpCas9	negative selection	4577331
76337821	76337843	15	-	27760321	HL60	viability	CCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	-0.4799943376946037	[584,401]	[304,264]	-5	hSpCas9	negative selection	4660790
76337842	76337864	15	+	27760321	HL60	viability	GGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	0.6198454726031408	[401,375]	[573,397]	7	hSpCas9	negative selection	4660791
76337896	76337918	15	-	27760321	HL60	viability	GCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	-0.2985415167736659	[888,697]	[458,591]	-3	hSpCas9	negative selection	4660792
76337916	76337938	15	+	27760321	HL60	viability	GCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	0.3017248594515294	[455,361]	[451,363]	4	hSpCas9	negative selection	4660793
76337943	76337965	15	-	27760321	HL60	viability	ACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	0.40450472395975107	[570,477]	[592,534]	5	hSpCas9	negative selection	4660794
76337821	76337843	15	-	27760321	HT1080	viability	CCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	0.9694550834383118	[401,313]	[284,272]	5	hSpCas9	negative selection	4744253
76337842	76337864	15	+	27760321	HT1080	viability	GGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	0.4874957222867625	[375,293]	[252,114]	2	hSpCas9	negative selection	4744254
76337896	76337918	15	-	27760321	HT1080	viability	GCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	-0.04571685658979274	[697,544]	[194,288]	0	hSpCas9	negative selection	4744255
76337916	76337938	15	+	27760321	HT1080	viability	GCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	1.2128374262570711	[361,282]	[251,347]	6	hSpCas9	negative selection	4744256
76337943	76337965	15	-	27760321	HT1080	viability	ACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	-0.2090033990360161	[477,372]	[96,200]	-1	hSpCas9	negative selection	4744257
76337821	76337843	15	-	27760321	HT29	viability after 7 days	CCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	0.6465259128662464	[401,313]	[955,637,603]	8	hSpCas9	negative selection	4827716
76337842	76337864	15	+	27760321	HT29	viability after 7 days	GGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	-0.14587014248731667	[375,293]	[335,502,322]	-2	hSpCas9	negative selection	4827717
76337896	76337918	15	-	27760321	HT29	viability after 7 days	GCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	0.17476256150757064	[697,544]	[791,994,901]	2	hSpCas9	negative selection	4827718
76337916	76337938	15	+	27760321	HT29	viability after 7 days	GCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	-0.11869043967878601	[361,282]	[353,523,266]	-2	hSpCas9	negative selection	4827719
76337943	76337965	15	-	27760321	HT29	viability after 7 days	ACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	0.055362220542064744	[477,372]	[759,724,256]	0	hSpCas9	negative selection	4827720
76337821	76337843	15	-	27760321	HT29	viability after 25 days	CCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	0.6925206746838467	[401,313]	[462,613,947]	7	hSpCas9	negative selection	4911179
76337842	76337864	15	+	27760321	HT29	viability after 25 days	GGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	0.49407066412294726	[375,293]	[690,354,563]	5	hSpCas9	negative selection	4911180
76337896	76337918	15	-	27760321	HT29	viability after 25 days	GCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	0.3628441533230222	[697,544]	[734,989,1037]	4	hSpCas9	negative selection	4911181
76337916	76337938	15	+	27760321	HT29	viability after 25 days	GCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	0.08704694198190628	[361,282]	[528,281,349]	0	hSpCas9	negative selection	4911182
76337943	76337965	15	-	27760321	HT29	viability after 25 days	ACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	0.46541161198632863	[477,372]	[508,742,782]	5	hSpCas9	negative selection	4911183
76337821	76337843	15	-	27760321	HT29	viability after 22 days	CCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	0.7393959326973659	[401,313]	[941,548,573]	8	hSpCas9	negative selection	4994642
76337842	76337864	15	+	27760321	HT29	viability after 22 days	GGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	0.6261320309880369	[375,293]	[663,381,746]	7	hSpCas9	negative selection	4994643
76337896	76337918	15	-	27760321	HT29	viability after 22 days	GCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	0.296964695892902	[697,544]	[1026,758,857]	3	hSpCas9	negative selection	4994644
76337916	76337938	15	+	27760321	HT29	viability after 22 days	GCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	0.005071277623542481	[361,282]	[303,384,435]	0	hSpCas9	negative selection	4994645
76337943	76337965	15	-	27760321	HT29	viability after 22 days	ACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	0.22750739822095795	[477,372]	[549,750,425]	2	hSpCas9	negative selection	4994646
76337821	76337843	15	-	27760321	HT29	viability after 19 days	CCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	1.0203548383437193	[401,313]	[581,1023,857]	9	hSpCas9	negative selection	5078105
76337842	76337864	15	+	27760321	HT29	viability after 19 days	GGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	0.3991956894282323	[375,293]	[573,528,422]	4	hSpCas9	negative selection	5078106
76337896	76337918	15	-	27760321	HT29	viability after 19 days	GCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	0.599271522419965	[697,544]	[913,1120,1173]	6	hSpCas9	negative selection	5078107
76337916	76337938	15	+	27760321	HT29	viability after 19 days	GCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	-0.014724886017138755	[361,282]	[409,489,205]	0	hSpCas9	negative selection	5078108
76337943	76337965	15	-	27760321	HT29	viability after 19 days	ACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	-0.15160737712737254	[477,372]	[363,444,494]	-1	hSpCas9	negative selection	5078109
76337821	76337843	15	-	27760321	HT29	viability after 16 days	CCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	0.585754200866312	[401,313]	[482,302,1013]	6	hSpCas9	negative selection	5161568
76337842	76337864	15	+	27760321	HT29	viability after 16 days	GGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	0.4422258327166959	[375,293]	[482,406,637]	5	hSpCas9	negative selection	5161569
76337896	76337918	15	-	27760321	HT29	viability after 16 days	GCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	0.1381068548632678	[697,544]	[647,781,853]	1	hSpCas9	negative selection	5161570
76337916	76337938	15	+	27760321	HT29	viability after 16 days	GCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	0.1438382587564679	[361,282]	[555,277,379]	1	hSpCas9	negative selection	5161571
76337943	76337965	15	-	27760321	HT29	viability after 16 days	ACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	0.40737066150917123	[477,372]	[506,678,694]	4	hSpCas9	negative selection	5161572
76337821	76337843	15	-	27760321	HT29	viability after 13 days	CCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	0.32792616579843703	[401,313]	[423,428,699]	4	hSpCas9	negative selection	5245031
76337842	76337864	15	+	27760321	HT29	viability after 13 days	GGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	0.06905746695349385	[375,293]	[401,461,361]	0	hSpCas9	negative selection	5245032
76337896	76337918	15	-	27760321	HT29	viability after 13 days	GCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	-0.06679787403878978	[697,544]	[551,715,790]	-1	hSpCas9	negative selection	5245033
76337916	76337938	15	+	27760321	HT29	viability after 13 days	GCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	0.6061841548223312	[361,282]	[575,671,466]	7	hSpCas9	negative selection	5245034
76337943	76337965	15	-	27760321	HT29	viability after 13 days	ACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	0.31506817437792733	[477,372]	[479,739,621]	4	hSpCas9	negative selection	5245035
76337821	76337843	15	-	27760321	HT29	viability after 10 days	CCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	0.6868182646167194	[401,313]	[710,571,867]	8	hSpCas9	negative selection	5328494
76337842	76337864	15	+	27760321	HT29	viability after 10 days	GGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	0.1433545012622727	[375,293]	[421,239,711]	1	hSpCas9	negative selection	5328495
76337896	76337918	15	-	27760321	HT29	viability after 10 days	GCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	0.17485796281684085	[697,544]	[828,1060,745]	2	hSpCas9	negative selection	5328496
76337916	76337938	15	+	27760321	HT29	viability after 10 days	GCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	-0.038466642103574006	[361,282]	[304,405,463]	0	hSpCas9	negative selection	5328497
76337943	76337965	15	-	27760321	HT29	viability after 10 days	ACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	0.10881582631027908	[477,372]	[702,483,529]	1	hSpCas9	negative selection	5328498
76337821	76337843	15	-	27760321	MOLM13	viability	CCGCAGGATAAACTGGTCGTGG	ISL2	ENSG00000159556	-0.7234257231711965	[584,401]	[164,167]	-4	hSpCas9	negative selection	5411957
76337842	76337864	15	+	27760321	MOLM13	viability	GGTGTCGCCCGACCTCGAGTGG	ISL2	ENSG00000159556	0.4988452615949237	[401,375]	[43,536]	3	hSpCas9	negative selection	5411958
76337896	76337918	15	-	27760321	MOLM13	viability	GCACGTCTCGTCCAGGTACTGG	ISL2	ENSG00000159556	-0.12149206803693957	[888,697]	[417,400]	-1	hSpCas9	negative selection	5411959
76337916	76337938	15	+	27760321	MOLM13	viability	GCACGTGCTTCGTGAGAGACGG	ISL2	ENSG00000159556	0.8208983154393314	[455,361]	[658,188]	6	hSpCas9	negative selection	5411960
76337943	76337965	15	-	27760321	MOLM13	viability	ACATAGTCCCGCTTGCAGTAGG	ISL2	ENSG00000159556	0.3093506272470293	[570,477]	[146,550]	2	hSpCas9	negative selection	5411961
76337902	76337925	15	-	27260156	BXPC3	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.05337853682388205	[670]	[586,692,643,798]	-1	hSpCas9	negative selection	5549806
76337946	76337969	15	+	27260156	BXPC3	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.21809464746758367	[659]	[767,779,845,818]	5	hSpCas9	negative selection	5549807
76338435	76338458	15	+	27260156	BXPC3	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.04223290200784968	[239]	[248,175,268,355]	0	hSpCas9	negative selection	5549808
76338379	76338402	15	-	27260156	BXPC3	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.028772728397681982	[472]	[476,522,395,543]	0	hSpCas9	negative selection	5614062
76336908	76336931	15	-	27260156	BXPC3	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.6288671347839794	[197]	[175,153,91,101]	-8	hSpCas9	negative selection	5614063
76337850	76337873	15	-	27260156	BXPC3	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.39548858894487593	[602]	[471,442,527,473]	-7	hSpCas9	negative selection	5614064
76337902	76337925	15	-	27260156	A673	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.02534789801594456	[670]	[909,681,746,845]	0	hSpCas9	negative selection	5671057
76337946	76337969	15	+	27260156	A673	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.2638825196352118	[659]	[1041,825,932,1020]	6	hSpCas9	negative selection	5671058
76338435	76338458	15	+	27260156	A673	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.10518916318605254	[239]	[356,277,294,315]	2	hSpCas9	negative selection	5671059
76338379	76338402	15	-	27260156	A673	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	0.12617940249486795	[472]	[562,555,561,802]	3	hSpCas9	negative selection	5735313
76336908	76336931	15	-	27260156	A673	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.4771966666442897	[197]	[174,167,145,195]	-8	hSpCas9	negative selection	5735314
76337850	76337873	15	-	27260156	A673	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.47566155116784536	[602]	[625,415,598,450]	-8	hSpCas9	negative selection	5735315
76337902	76337925	15	-	27260156	A375	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.07661428446308655	[670]	[788,916,735,572]	-1	hSpCas9	negative selection	5792308
76337946	76337969	15	+	27260156	A375	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.6293273255435122	[659]	[868,1785,1069,1127]	8	hSpCas9	negative selection	5792309
76338435	76338458	15	+	27260156	A375	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.18542228575341713	[239]	[320,284,296,360]	2	hSpCas9	negative selection	5792310
76338379	76338402	15	-	27260156	A375	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.14209525720314992	[472]	[544,442,578,433]	-2	hSpCas9	negative selection	5856564
76336908	76336931	15	-	27260156	A375	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.984380545754614	[197]	[169,96,184,23]	-8	hSpCas9	negative selection	5856565
76337850	76337873	15	-	27260156	A375	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.6551790919510693	[602]	[524,377,389,480]	-7	hSpCas9	negative selection	5856566
76337902	76337925	15	-	27260156	COLO741	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.12129083208252972	[670]	[723,781,846]	-3	hSpCas9	negative selection	5913559
76337946	76337969	15	+	27260156	COLO741	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.434130025590332	[659]	[1104,1325,992]	8	hSpCas9	negative selection	5913560
76338435	76338458	15	+	27260156	COLO741	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.11306061272734214	[239]	[338,298,354]	2	hSpCas9	negative selection	5913561
76338379	76338402	15	-	27260156	COLO741	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.47505709222877773	[472]	[513,500,304]	-7	hSpCas9	negative selection	5977815
76336908	76336931	15	-	27260156	COLO741	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.32443208999556905	[197]	[270,188,154]	-6	hSpCas9	negative selection	5977816
76337850	76337873	15	-	27260156	COLO741	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.7868624533167963	[602]	[426,601,317]	-9	hSpCas9	negative selection	5977817
76337902	76337925	15	-	27260156	CAL120	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	0.12356880791736391	[670]	[1186,823,761]	1	hSpCas9	negative selection	6034810
76337946	76337969	15	+	27260156	CAL120	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.4906303035695655	[659]	[1958,997,634]	7	hSpCas9	negative selection	6034811
76338435	76338458	15	+	27260156	CAL120	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	-0.1283496661642758	[239]	[227,435,150]	-2	hSpCas9	negative selection	6034812
76338379	76338402	15	-	27260156	CAL120	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.020105013585788548	[472]	[522,658,550]	0	hSpCas9	negative selection	6099066
76336908	76336931	15	-	27260156	CAL120	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	0.43410527580937674	[197]	[240,91,645]	6	hSpCas9	negative selection	6099067
76337850	76337873	15	-	27260156	CAL120	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.10095645251440871	[602]	[754,540,808]	-1	hSpCas9	negative selection	6099068
76337902	76337925	15	-	27260156	CADOES1	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.23649419050008236	[670]	[566,586,508,452]	-4	hSpCas9	negative selection	6156061
76337946	76337969	15	+	27260156	CADOES1	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.5241954984947806	[659]	[945,874,876,830]	8	hSpCas9	negative selection	6156062
76338435	76338458	15	+	27260156	CADOES1	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	-0.12604264375663976	[239]	[185,124,302,203]	-2	hSpCas9	negative selection	6156063
76338379	76338402	15	-	27260156	CADOES1	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.3106708927860958	[472]	[325,357,375,358]	-5	hSpCas9	negative selection	6220317
76336908	76336931	15	-	27260156	CADOES1	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.8718546326942362	[197]	[66,74,147,112]	-9	hSpCas9	negative selection	6220318
76337850	76337873	15	-	27260156	CADOES1	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.8571241780887784	[602]	[258,365,320,291]	-9	hSpCas9	negative selection	6220319
76337902	76337925	15	-	27260156	EWS502	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.2360638677135235	[670]	[542,471,710,706]	-4	hSpCas9	negative selection	6277312
76337946	76337969	15	+	27260156	EWS502	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.41166331274235435	[659]	[910,966,899,938]	7	hSpCas9	negative selection	6277313
76338435	76338458	15	+	27260156	EWS502	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	-0.012914684144319843	[239]	[210,328,281,181]	0	hSpCas9	negative selection	6277314
76338379	76338402	15	-	27260156	EWS502	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.2460167694875725	[472]	[359,509,476,339]	-4	hSpCas9	negative selection	6341568
76336908	76336931	15	-	27260156	EWS502	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.5033768413093038	[197]	[137,118,207,127]	-7	hSpCas9	negative selection	6341569
76337850	76337873	15	-	27260156	EWS502	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.6957117911177397	[602]	[421,384,442,317]	-8	hSpCas9	negative selection	6341570
76337902	76337925	15	-	27260156	EW8	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.17615182804934693	[670]	[632,470,377,475]	-3	hSpCas9	negative selection	6398563
76337946	76337969	15	+	27260156	EW8	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.5876166295111941	[659]	[813,813,797,788]	9	hSpCas9	negative selection	6398564
76338435	76338458	15	+	27260156	EW8	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.08889731256222899	[239]	[224,137,226,234]	1	hSpCas9	negative selection	6398565
76338379	76338402	15	-	27260156	EW8	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.2701713588263649	[472]	[375,309,293,300]	-5	hSpCas9	negative selection	6462819
76336908	76336931	15	-	27260156	EW8	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.41296512162804433	[197]	[245,79,105,65]	-6	hSpCas9	negative selection	6462820
76337850	76337873	15	-	27260156	EW8	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.34749746606218884	[602]	[588,491,234,267]	-6	hSpCas9	negative selection	6462821
76337902	76337925	15	-	27260156	CORL105	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.12214534733177723	[670]	[842,705,654,676]	-2	hSpCas9	negative selection	6519814
76337946	76337969	15	+	27260156	CORL105	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.3861907486545443	[659]	[1243,860,1014,930]	7	hSpCas9	negative selection	6519815
76338435	76338458	15	+	27260156	CORL105	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.14130719660826996	[239]	[266,353,346,274]	2	hSpCas9	negative selection	6519816
76338379	76338402	15	-	27260156	CORL105	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.2457861357901284	[472]	[355,431,653,451]	-4	hSpCas9	negative selection	6584070
76336908	76336931	15	-	27260156	CORL105	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.838031929766659	[197]	[191,74,167,92]	-9	hSpCas9	negative selection	6584071
76337850	76337873	15	-	27260156	CORL105	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.7614832676060587	[602]	[433,369,366,487]	-8	hSpCas9	negative selection	6584072
76337902	76337925	15	-	27260156	HS294T	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.3387726980527588	[670]	[129,176,251,281]	-5	hSpCas9	negative selection	6641065
76337946	76337969	15	+	27260156	HS294T	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.6607330776230319	[659]	[307,458,322,554]	8	hSpCas9	negative selection	6641066
76338435	76338458	15	+	27260156	HS294T	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.7203694709607064	[239]	[90,213,126,188]	8	hSpCas9	negative selection	6641067
76338379	76338402	15	-	27260156	HS294T	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.35647111003496745	[472]	[106,106,176,192]	-5	hSpCas9	negative selection	6705321
76336908	76336931	15	-	27260156	HS294T	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.765322684908426	[197]	[33,27,72,46]	-8	hSpCas9	negative selection	6705322
76337850	76337873	15	-	27260156	HS294T	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.5983570717779993	[602]	[117,167,130,210]	-7	hSpCas9	negative selection	6705323
76337902	76337925	15	-	27260156	HCC44	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.15663426238406747	[670]	[1065,421,621,669]	-3	hSpCas9	negative selection	6762316
76337946	76337969	15	+	27260156	HCC44	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.5522103100656716	[659]	[856,1042,1198,1267]	8	hSpCas9	negative selection	6762317
76338435	76338458	15	+	27260156	HCC44	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.029938659350961183	[239]	[365,241,162,326]	0	hSpCas9	negative selection	6762318
76338379	76338402	15	-	27260156	HCC44	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.21231509014092295	[472]	[527,293,611,464]	-3	hSpCas9	negative selection	6826572
76336908	76336931	15	-	27260156	HCC44	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-1.3477569077564142	[197]	[89,82,102,78]	-9	hSpCas9	negative selection	6826573
76337850	76337873	15	-	27260156	HCC44	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.9397886336372147	[602]	[298,241,553,368]	-8	hSpCas9	negative selection	6826574
76337902	76337925	15	-	27260156	G402	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.009870662642329275	[670]	[968,1161,595,576]	0	hSpCas9	negative selection	6883567
76337946	76337969	15	+	27260156	G402	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.6268486455328587	[659]	[1297,1536,1457,726]	7	hSpCas9	negative selection	6883568
76338435	76338458	15	+	27260156	G402	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.10799533843012565	[239]	[138,295,492,306]	1	hSpCas9	negative selection	6883569
76338379	76338402	15	-	27260156	G402	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.6108692243854926	[472]	[232,380,423,447]	-6	hSpCas9	negative selection	6947823
76336908	76336931	15	-	27260156	G402	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-2.541406881294418	[197]	[72,48,10,37]	-9	hSpCas9	negative selection	6947824
76337850	76337873	15	-	27260156	G402	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.7631669286937358	[602]	[376,706,367,294]	-7	hSpCas9	negative selection	6947825
76337902	76337925	15	-	27260156	L33	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.0973965589449668	[670]	[553,271,378,688]	-2	hSpCas9	negative selection	7004818
76337946	76337969	15	+	27260156	L33	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.09667966202627276	[659]	[766,258,374,823]	2	hSpCas9	negative selection	7004819
76338435	76338458	15	+	27260156	L33	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.5914749586488388	[239]	[282,170,185,450]	9	hSpCas9	negative selection	7004820
76338379	76338402	15	-	27260156	L33	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.2719115188856937	[472]	[414,152,276,337]	-6	hSpCas9	negative selection	7069074
76336908	76336931	15	-	27260156	L33	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.02611044813226382	[197]	[178,68,132,218]	0	hSpCas9	negative selection	7069075
76337850	76337873	15	-	27260156	L33	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.5301397838998676	[602]	[429,192,278,325]	-8	hSpCas9	negative selection	7069076
76337902	76337925	15	-	27260156	K562	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.3934256240983387	[670]	[320,528,495,457]	-5	hSpCas9	negative selection	7126069
76337946	76337969	15	+	27260156	K562	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.5132627729762004	[659]	[1305,913,535,648]	6	hSpCas9	negative selection	7126070
76338435	76338458	15	+	27260156	K562	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	-0.4087869071195289	[239]	[208,114,123,190]	-5	hSpCas9	negative selection	7126071
76338379	76338402	15	-	27260156	K562	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.20495534231637258	[472]	[207,447,532,268]	-3	hSpCas9	negative selection	7190325
76336908	76336931	15	-	27260156	K562	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.2899492790730749	[197]	[136,89,21,302]	-4	hSpCas9	negative selection	7190326
76337850	76337873	15	-	27260156	K562	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-1.0210610745969253	[602]	[172,250,286,326]	-8	hSpCas9	negative selection	7190327
76337902	76337925	15	-	27260156	HT29	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.21803075676302697	[670]	[826,698,721,576]	-4	hSpCas9	negative selection	7247320
76337946	76337969	15	+	27260156	HT29	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.12649303052359528	[659]	[839,1052,871,758]	2	hSpCas9	negative selection	7247321
76338435	76338458	15	+	27260156	HT29	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	-0.225297025350486	[239]	[243,230,292,228]	-4	hSpCas9	negative selection	7247322
76338379	76338402	15	-	27260156	HT29	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.11614582624556505	[472]	[484,514,534,572]	-2	hSpCas9	negative selection	7311576
76336908	76336931	15	-	27260156	HT29	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.2827222652854344	[197]	[283,184,177,153]	-5	hSpCas9	negative selection	7311577
76337850	76337873	15	-	27260156	HT29	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.8026486523513134	[602]	[378,434,459,403]	-8	hSpCas9	negative selection	7311578
76337902	76337925	15	-	27260156	MHHES1	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.12887542743055241	[670]	[699,751,661,650]	-2	hSpCas9	negative selection	7368571
76337946	76337969	15	+	27260156	MHHES1	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.09560969441771894	[659]	[935,868,790,626]	1	hSpCas9	negative selection	7368572
76338435	76338458	15	+	27260156	MHHES1	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.23143609543158883	[239]	[304,332,316,308]	4	hSpCas9	negative selection	7368573
76338379	76338402	15	-	27260156	MHHES1	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.11669688510662685	[472]	[360,590,624,394]	-2	hSpCas9	negative selection	7432827
76336908	76336931	15	-	27260156	MHHES1	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.04000797153600222	[197]	[293,207,234,149]	0	hSpCas9	negative selection	7432828
76337850	76337873	15	-	27260156	MHHES1	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-1.056482059861539	[602]	[373,397,420,158]	-9	hSpCas9	negative selection	7432829
76337902	76337925	15	-	27260156	MEWO	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.19390135084581867	[670]	[705,501,468]	-4	hSpCas9	negative selection	7489822
76337946	76337969	15	+	27260156	MEWO	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.4663663991109057	[659]	[1114,829,664]	8	hSpCas9	negative selection	7489823
76338435	76338458	15	+	27260156	MEWO	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.17950984198169273	[239]	[295,229,244]	4	hSpCas9	negative selection	7489824
76338379	76338402	15	-	27260156	MEWO	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.16319992403224742	[472]	[483,330,387]	-4	hSpCas9	negative selection	7554078
76336908	76336931	15	-	27260156	MEWO	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.48997464310202843	[197]	[179,128,95]	-8	hSpCas9	negative selection	7554079
76337850	76337873	15	-	27260156	MEWO	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.43718504919641304	[602]	[579,321,379]	-7	hSpCas9	negative selection	7554080
76337902	76337925	15	-	27260156	LNCAPCLONEFGC	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.12340148064493262	[670]	[575,582,472,584]	-2	hSpCas9	negative selection	7611073
76337946	76337969	15	+	27260156	LNCAPCLONEFGC	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.4738166760467253	[659]	[997,597,858,881]	7	hSpCas9	negative selection	7611074
76338435	76338458	15	+	27260156	LNCAPCLONEFGC	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.1155015861554044	[239]	[263,135,201,340]	1	hSpCas9	negative selection	7611075
76338379	76338402	15	-	27260156	LNCAPCLONEFGC	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	0.05303476935277129	[472]	[608,363,350,441]	0	hSpCas9	negative selection	7675329
76336908	76336931	15	-	27260156	LNCAPCLONEFGC	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.983094753132179	[197]	[44,119,138,64]	-8	hSpCas9	negative selection	7675330
76337850	76337873	15	-	27260156	LNCAPCLONEFGC	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.5837689680095249	[602]	[326,291,410,439]	-7	hSpCas9	negative selection	7675331
76337902	76337925	15	-	27260156	PANC0327	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.07637912125678226	[670]	[857,457,540,441]	-1	hSpCas9	negative selection	7732324
76337946	76337969	15	+	27260156	PANC0327	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.2731641484367031	[659]	[571,605,854,802]	4	hSpCas9	negative selection	7732325
76338435	76338458	15	+	27260156	PANC0327	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	-0.047691437307133544	[239]	[202,119,296,215]	0	hSpCas9	negative selection	7732326
76338379	76338402	15	-	27260156	PANC0327	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.4999864933280384	[472]	[373,316,237,262]	-6	hSpCas9	negative selection	7796580
76336908	76336931	15	-	27260156	PANC0327	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.26388278225400974	[197]	[133,20,159,285]	-4	hSpCas9	negative selection	7796581
76337850	76337873	15	-	27260156	PANC0327	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.561145958326915	[602]	[431,344,329,352]	-7	hSpCas9	negative selection	7796582
76337902	76337925	15	-	27260156	NCIH2009	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.23040776608699365	[670]	[868,897,640]	-3	hSpCas9	negative selection	7853575
76337946	76337969	15	+	27260156	NCIH2009	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.5822197916324755	[659]	[1628,1018,1546]	7	hSpCas9	negative selection	7853576
76338435	76338458	15	+	27260156	NCIH2009	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.6782822466405292	[239]	[719,431,494]	8	hSpCas9	negative selection	7853577
76338379	76338402	15	-	27260156	NCIH2009	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	0.051681528565223164	[472]	[851,669,564]	0	hSpCas9	negative selection	7917831
76336908	76336931	15	-	27260156	NCIH2009	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.2357527266534336	[197]	[493,157,104]	-3	hSpCas9	negative selection	7917832
76337850	76337873	15	-	27260156	NCIH2009	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.4355198578115912	[602]	[801,578,522]	-5	hSpCas9	negative selection	7917833
76337902	76337925	15	-	27260156	NCIH1373	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.05216528739227705	[670]	[721,404,1315,120]	0	hSpCas9	negative selection	7974826
76337946	76337969	15	+	27260156	NCIH1373	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.5853246763678323	[659]	[1270,746,1279,315]	6	hSpCas9	negative selection	7974827
76338435	76338458	15	+	27260156	NCIH1373	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	-0.6495088050905018	[239]	[118,184,167,53]	-6	hSpCas9	negative selection	7974828
76338379	76338402	15	-	27260156	NCIH1373	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.42530737128255486	[472]	[320,308,426,137]	-4	hSpCas9	negative selection	8039082
76336908	76336931	15	-	27260156	NCIH1373	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.42451612724269516	[197]	[198,102,128,64]	-4	hSpCas9	negative selection	8039083
76337850	76337873	15	-	27260156	NCIH1373	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.6930605455558805	[602]	[596,232,576,78]	-6	hSpCas9	negative selection	8039084
76337902	76337925	15	-	27260156	PATU8902	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.159689485159217	[670]	[1188,1043,555,589]	-2	hSpCas9	negative selection	8096077
76337946	76337969	15	+	27260156	PATU8902	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.8159206100500281	[659]	[1863,1012,1380,2344]	8	hSpCas9	negative selection	8096078
76338435	76338458	15	+	27260156	PATU8902	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	-0.05845961310961201	[239]	[461,493,120,245]	0	hSpCas9	negative selection	8096079
76338379	76338402	15	-	27260156	PATU8902	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.029589528983001573	[472]	[551,614,537,934]	0	hSpCas9	negative selection	8160333
76336908	76336931	15	-	27260156	PATU8902	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.6394860305576024	[197]	[176,194,153,187]	-6	hSpCas9	negative selection	8160334
76337850	76337873	15	-	27260156	PATU8902	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-1.004082864381477	[602]	[1067,148,199,285]	-7	hSpCas9	negative selection	8160335
76337902	76337925	15	-	27260156	PANC1	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.10690167902914971	[670]	[442,613,550,540]	-2	hSpCas9	negative selection	8217328
76337946	76337969	15	+	27260156	PANC1	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.4745214145285125	[659]	[690,808,939,716]	7	hSpCas9	negative selection	8217329
76338435	76338458	15	+	27260156	PANC1	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.22709396252463276	[239]	[161,140,276,344]	3	hSpCas9	negative selection	8217330
76338379	76338402	15	-	27260156	PANC1	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	0.01635631648039291	[472]	[421,450,424,355]	0	hSpCas9	negative selection	8281584
76336908	76336931	15	-	27260156	PANC1	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.20004551030172513	[197]	[239,149,126,81]	-3	hSpCas9	negative selection	8281585
76337850	76337873	15	-	27260156	PANC1	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.5524311220549651	[602]	[200,592,397,279]	-7	hSpCas9	negative selection	8281586
76337902	76337925	15	-	27260156	PANC0813	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	0.05512490803677039	[670]	[874,803,760,837]	0	hSpCas9	negative selection	8338579
76337946	76337969	15	+	27260156	PANC0813	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.15092263786386306	[659]	[914,755,898,875]	2	hSpCas9	negative selection	8338580
76338435	76338458	15	+	27260156	PANC0813	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.37196351531641203	[239]	[375,379,499,212]	6	hSpCas9	negative selection	8338581
76338379	76338402	15	-	27260156	PANC0813	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.04606764662523215	[472]	[628,340,570,614]	0	hSpCas9	negative selection	8402835
76336908	76336931	15	-	27260156	PANC0813	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.38750786291377315	[197]	[138,117,327,125]	-5	hSpCas9	negative selection	8402836
76337850	76337873	15	-	27260156	PANC0813	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.7020320606328359	[602]	[565,319,379,483]	-7	hSpCas9	negative selection	8402837
76337902	76337925	15	-	27260156	RDES	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.09880920397432258	[670]	[654,650,778,810]	-2	hSpCas9	negative selection	8459830
76337946	76337969	15	+	27260156	RDES	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.5956101438500448	[659]	[765,1101,1193,1661]	8	hSpCas9	negative selection	8459831
76338435	76338458	15	+	27260156	RDES	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.3146325411194958	[239]	[177,336,564,326]	5	hSpCas9	negative selection	8459832
76338379	76338402	15	-	27260156	RDES	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	0.1715703713679954	[472]	[547,772,630,451]	2	hSpCas9	negative selection	8524086
76336908	76336931	15	-	27260156	RDES	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.6966368844775577	[197]	[69,140,159,214]	-8	hSpCas9	negative selection	8524087
76337850	76337873	15	-	27260156	RDES	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.6646900010829638	[602]	[370,328,454,637]	-8	hSpCas9	negative selection	8524088
76337902	76337925	15	-	27260156	PC3	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	0.10695970153592926	[670]	[489,588,1181,838]	2	hSpCas9	negative selection	8581081
76337946	76337969	15	+	27260156	PC3	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.40759736357113463	[659]	[552,758,1698,862]	8	hSpCas9	negative selection	8581082
76338435	76338458	15	+	27260156	PC3	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	-0.34498003326445126	[239]	[99,117,308,305]	-7	hSpCas9	negative selection	8581083
76338379	76338402	15	-	27260156	PC3	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.2956543325697896	[472]	[263,370,605,394]	-6	hSpCas9	negative selection	8645337
76336908	76336931	15	-	27260156	PC3	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.09396643212114109	[197]	[130,221,197,194]	-2	hSpCas9	negative selection	8645338
76337850	76337873	15	-	27260156	PC3	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.8281146041267728	[602]	[187,280,766,324]	-9	hSpCas9	negative selection	8645339
76337902	76337925	15	-	27260156	PATU8988T	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	0.132157390719015	[670]	[679,587,1033,507]	2	hSpCas9	negative selection	8702332
76337946	76337969	15	+	27260156	PATU8988T	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.37295546830198734	[659]	[719,1111,745,746]	6	hSpCas9	negative selection	8702333
76338435	76338458	15	+	27260156	PATU8988T	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	-0.20134605075863732	[239]	[201,149,142,316]	-3	hSpCas9	negative selection	8702334
76338379	76338402	15	-	27260156	PATU8988T	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	0.08310197101831074	[472]	[379,512,337,729]	1	hSpCas9	negative selection	8766588
76336908	76336931	15	-	27260156	PATU8988T	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-1.535639564742308	[197]	[32,80,46,107]	-9	hSpCas9	negative selection	8766589
76337850	76337873	15	-	27260156	PATU8988T	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.5182976941406933	[602]	[250,510,575,286]	-7	hSpCas9	negative selection	8766590
76337902	76337925	15	-	27260156	T47D	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.24204353526022704	[670]	[681,649,546,770]	-5	hSpCas9	negative selection	8823583
76337946	76337969	15	+	27260156	T47D	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.22508634532699967	[659]	[916,785,936,965]	5	hSpCas9	negative selection	8823584
76338435	76338458	15	+	27260156	T47D	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.2195164222984317	[239]	[324,361,357,250]	5	hSpCas9	negative selection	8823585
76338379	76338402	15	-	27260156	T47D	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.12220905929352388	[472]	[494,582,441,498]	-3	hSpCas9	negative selection	8887839
76336908	76336931	15	-	27260156	T47D	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.5821195271378343	[197]	[175,179,142,113]	-8	hSpCas9	negative selection	8887840
76337850	76337873	15	-	27260156	T47D	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.5589786927134788	[602]	[510,500,460,430]	-8	hSpCas9	negative selection	8887841
76337902	76337925	15	-	27260156	SU8686	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.21139173323533783	[670]	[669,570,504,527]	-4	hSpCas9	negative selection	8944834
76337946	76337969	15	+	27260156	SU8686	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.15426284415747993	[659]	[597,617,888,856]	2	hSpCas9	negative selection	8944835
76338435	76338458	15	+	27260156	SU8686	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.37664974218670844	[239]	[315,282,225,427]	6	hSpCas9	negative selection	8944836
76338379	76338402	15	-	27260156	SU8686	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.1701665220665408	[472]	[329,395,424,546]	-3	hSpCas9	negative selection	9009090
76336908	76336931	15	-	27260156	SU8686	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.05877097970220957	[197]	[259,171,158,147]	-1	hSpCas9	negative selection	9009091
76337850	76337873	15	-	27260156	SU8686	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.6394902987015774	[602]	[286,397,387,484]	-7	hSpCas9	negative selection	9009092
76337902	76337925	15	-	27260156	SKES1	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	0.0006338005364412425	[670]	[749,658,736,548]	0	hSpCas9	negative selection	9066085
76337946	76337969	15	+	27260156	SKES1	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.3962336803721527	[659]	[957,946,822,763]	7	hSpCas9	negative selection	9066086
76338435	76338458	15	+	27260156	SKES1	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	-0.38623450319372377	[239]	[188,223,233,98]	-7	hSpCas9	negative selection	9066087
76338379	76338402	15	-	27260156	SKES1	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.4543781060911279	[472]	[509,332,311,251]	-7	hSpCas9	negative selection	9130341
76336908	76336931	15	-	27260156	SKES1	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.38721739504904074	[197]	[129,164,142,161]	-7	hSpCas9	negative selection	9130342
76337850	76337873	15	-	27260156	SKES1	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.5708800467097885	[602]	[514,469,368,297]	-8	hSpCas9	negative selection	9130343
76337902	76337925	15	-	27260156	TOV112D	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	0.3198080607844911	[670]	[1099,925,701,673]	6	hSpCas9	negative selection	9187336
76337946	76337969	15	+	27260156	TOV112D	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.638496240397591	[659]	[1144,1602,872,654]	9	hSpCas9	negative selection	9187337
76338435	76338458	15	+	27260156	TOV112D	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.2638497441155704	[239]	[309,412,269,195]	5	hSpCas9	negative selection	9187338
76338379	76338402	15	-	27260156	TOV112D	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.4910166024350138	[472]	[352,332,249,409]	-7	hSpCas9	negative selection	9251592
76336908	76336931	15	-	27260156	TOV112D	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.5076169918755287	[197]	[121,144,201,89]	-7	hSpCas9	negative selection	9251593
76337850	76337873	15	-	27260156	TOV112D	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.16033377459630738	[602]	[363,507,800,466]	-3	hSpCas9	negative selection	9251594
76337902	76337925	15	-	27260156	TC71	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.03654079615797362	[670]	[694,651,679,783]	-1	hSpCas9	negative selection	9308587
76337946	76337969	15	+	27260156	TC71	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.11135581013911244	[659]	[825,650,702,884]	3	hSpCas9	negative selection	9308588
76338435	76338458	15	+	27260156	TC71	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	0.2933935929303495	[239]	[281,290,321,369]	7	hSpCas9	negative selection	9308589
76338379	76338402	15	-	27260156	TC71	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.2368395354444517	[472]	[497,407,344,473]	-6	hSpCas9	negative selection	9372843
76336908	76336931	15	-	27260156	TC71	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.7121200164063448	[197]	[108,175,79,156]	-9	hSpCas9	negative selection	9372844
76337850	76337873	15	-	27260156	TC71	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.4099931051348688	[602]	[417,472,554,499]	-8	hSpCas9	negative selection	9372845
76337902	76337925	15	-	27260156	TC32	viability	AGCACGTGCACGTCTCGTCCAGG	ISL2	ENSG00000159556	-0.08937676180016946	[670]	[529,392,759,776]	-1	hSpCas9	negative selection	9429838
76337946	76337969	15	+	27260156	TC32	viability	ACTGCAAGCGGGACTATGTCAGG	ISL2	ENSG00000159556	0.37783549901309676	[659]	[708,575,1031,1009]	6	hSpCas9	negative selection	9429839
76338435	76338458	15	+	27260156	TC32	viability	CCTCCTGCTCGAGCGCGCCGCGG	ISL2	ENSG00000159556	-0.13304760879719613	[239]	[190,145,275,235]	-2	hSpCas9	negative selection	9429840
76338379	76338402	15	-	27260156	TC32	viability	CGCAGCGAGAACTCGTCCCCAGG	ISL2	ENSG00000159556	-0.1317454499306071	[472]	[350,332,574,402]	-2	hSpCas9	negative selection	9494094
76336908	76336931	15	-	27260156	TC32	viability	TCACCCATAGCACCCAGAAAAGG	ISL2	ENSG00000159556	-0.4510152168625632	[197]	[56,168,221,97]	-7	hSpCas9	negative selection	9494095
76337850	76337873	15	-	27260156	TC32	viability	GGCCGCGTGCCACTCGAGGTCGG	ISL2	ENSG00000159556	-0.8367718997032721	[602]	[244,226,503,352]	-9	hSpCas9	negative selection	9494096
76337793	76337816	15	-	27869803	HPAFII	viability after 27 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	-0.259635281859683	[1115]	[380,580,NaN]	-2	hSpCas9	negative selection	9554883
76337827	76337850	15	-	27869803	HPAFII	viability after 27 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.7480167337947985	[441]	[374,402,NaN]	6	hSpCas9	negative selection	9554884
76338303	76338326	15	-	27869803	HPAFII	viability after 27 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	-0.22237481042048776	[255]	[170,68,NaN]	-2	hSpCas9	negative selection	9554885
76337793	76337816	15	-	27869803	HPAFII	viability after 15 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	0.0902016814543094	[1115]	[1618,1063,NaN]	1	hSpCas9	negative selection	9637332
76337827	76337850	15	-	27869803	HPAFII	viability after 15 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.36674745085179516	[441]	[696,559,NaN]	4	hSpCas9	negative selection	9637333
76338303	76338326	15	-	27869803	HPAFII	viability after 15 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.47712646712541174	[255]	[628,229,NaN]	5	hSpCas9	negative selection	9637334
76337793	76337816	15	-	27869803	ASPC1	viability after 36 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	-0.23212200258554505	[2572]	[517,1179,599]	-2	hSpCas9	negative selection	9719781
76337827	76337850	15	-	27869803	ASPC1	viability after 36 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.3034528804219476	[894]	[261,575,316]	3	hSpCas9	negative selection	9719782
76338303	76338326	15	-	27869803	ASPC1	viability after 36 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.9287797404535088	[687]	[373,408,548]	8	hSpCas9	negative selection	9719783
76337793	76337816	15	-	27869803	PATU8988S	viability after 35 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	0.2174647342420717	[2239]	[799,1298,NaN]	2	hSpCas9	negative selection	9802230
76337827	76337850	15	-	27869803	PATU8988S	viability after 35 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	-0.08158038760695485	[840]	[359,279,NaN]	-1	hSpCas9	negative selection	9802231
76338303	76338326	15	-	27869803	PATU8988S	viability after 35 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	-0.6476629150909674	[833]	[172,255,NaN]	-6	hSpCas9	negative selection	9802232
76337793	76337816	15	-	27869803	PATU8988S	viability after 31 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	0.096808266983059	[2239]	[648,1344,NaN]	1	hSpCas9	negative selection	9884679
76337827	76337850	15	-	27869803	PATU8988S	viability after 31 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	-0.3689399863808353	[840]	[227,299,NaN]	-4	hSpCas9	negative selection	9884680
76338303	76338326	15	-	27869803	PATU8988S	viability after 31 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	-0.5295303510052897	[833]	[159,319,NaN]	-5	hSpCas9	negative selection	9884681
76337793	76337816	15	-	27869803	HPAFII	viability after 35 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	-0.43024677865734895	[1115]	[161,708,NaN]	-3	hSpCas9	negative selection	9967128
76337827	76337850	15	-	27869803	HPAFII	viability after 35 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.7737777048547534	[441]	[351,416,NaN]	5	hSpCas9	negative selection	9967129
76338303	76338326	15	-	27869803	HPAFII	viability after 35 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.2455386954196507	[255]	[147,159,NaN]	1	hSpCas9	negative selection	9967130
76337793	76337816	15	-	27869803	HPAFII	viability after 31 days	ACTCCCGCAGCCCACGCACATGG	ISL2	ENSG00000159556	-0.4457305819641373	[1115]	[221,718,NaN]	-3	hSpCas9	negative selection	10049577
76337827	76337850	15	-	27869803	HPAFII	viability after 31 days	GCGACACCCGCAGGATAAACTGG	ISL2	ENSG00000159556	0.7686419818025132	[441]	[424,419,NaN]	5	hSpCas9	negative selection	10049578
76338303	76338326	15	-	27869803	HPAFII	viability after 31 days	TGTCCCGCGCCCTCATCACCAGG	ISL2	ENSG00000159556	0.37844598931002327	[255]	[147,228,NaN]	2	hSpCas9	negative selection	10049579
76338264	76338287	15	+	28162770	P31FUJ	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	0.6471670918788514	[237]	[437]	7	hSpCas9	negative selection	10175953
76338348	76338371	15	-	28162770	P31FUJ	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	1.1925036303182923	[104]	[281]	9	hSpCas9	negative selection	10175954
76337871	76337894	15	-	28162770	P31FUJ	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.721770379404116	[370]	[718]	8	hSpCas9	negative selection	10175955
76338264	76338287	15	+	28162770	TF1	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	NaN	[NaN]	[282]	1	hSpCas9	negative selection	10345319
76338348	76338371	15	-	28162770	TF1	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	NaN	[NaN]	[84]	1	hSpCas9	negative selection	10345320
76337871	76337894	15	-	28162770	TF1	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	NaN	[NaN]	[470]	1	hSpCas9	negative selection	10345321
76338264	76338287	15	+	28162770	SKM1	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	0.6576078025529222	[70]	[197]	6	hSpCas9	negative selection	10514685
76338348	76338371	15	-	28162770	SKM1	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	0.832862815929307	[46]	[147]	7	hSpCas9	negative selection	10514686
76337871	76337894	15	-	28162770	SKM1	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.9892366585228267	[105]	[371]	8	hSpCas9	negative selection	10514687
76338264	76338287	15	+	28162770	SKM1	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	0.6576078025529222	[70]	[197]	6	hSpCas9	negative selection	10684051
76338348	76338371	15	-	28162770	SKM1	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	0.832862815929307	[46]	[147]	7	hSpCas9	negative selection	10684052
76337871	76337894	15	-	28162770	SKM1	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.9892366585228267	[105]	[371]	8	hSpCas9	negative selection	10684053
76338264	76338287	15	+	28162770	PL21	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	0.6802329973565211	[270]	[188]	6	hSpCas9	negative selection	10853417
76338348	76338371	15	-	28162770	PL21	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	0.16451570475859872	[122]	[59]	1	hSpCas9	negative selection	10853418
76337871	76337894	15	-	28162770	PL21	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	1.3903234549154324	[219]	[250]	9	hSpCas9	negative selection	10853419
76338264	76338287	15	+	28162770	P31FUJ	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	0.6471670918788514	[237]	[437]	7	hSpCas9	negative selection	11022783
76338348	76338371	15	-	28162770	P31FUJ	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	1.1925036303182923	[104]	[281]	9	hSpCas9	negative selection	11022784
76337871	76337894	15	-	28162770	P31FUJ	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.721770379404116	[370]	[718]	8	hSpCas9	negative selection	11022785
76338264	76338287	15	+	28162770	OCIAML5	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	1.1312546879893726	[86]	[343]	8	hSpCas9	negative selection	11192149
76338348	76338371	15	-	28162770	OCIAML5	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	-0.2267463325266998	[93]	[144]	-2	hSpCas9	negative selection	11192150
76337871	76337894	15	-	28162770	OCIAML5	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.37573934665881503	[265]	[622]	3	hSpCas9	negative selection	11192151
76338264	76338287	15	+	28162770	EOL1	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	-0.3062324352586325	[459]	[195]	-2	hSpCas9	negative selection	11361515
76338348	76338371	15	-	28162770	EOL1	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	-0.1359937703645162	[291]	[139]	-1	hSpCas9	negative selection	11361516
76337871	76337894	15	-	28162770	EOL1	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.383979390207832	[463]	[318]	3	hSpCas9	negative selection	11361517
76338264	76338287	15	+	28162770	MOLM13	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	0.9706371189775472	[342]	[485]	7	hSpCas9	negative selection	11530881
76338348	76338371	15	-	28162770	MOLM13	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	0.5563273462121627	[173]	[184]	4	hSpCas9	negative selection	11530882
76337871	76337894	15	-	28162770	MOLM13	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.5001657845683348	[441]	[451]	4	hSpCas9	negative selection	11530883
76338264	76338287	15	+	28162770	HEL	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	0.7947419254454071	[323]	[359]	7	hSpCas9	negative selection	11700247
76338348	76338371	15	-	28162770	HEL	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	0.7302016732506964	[191]	[203]	6	hSpCas9	negative selection	11700248
76337871	76337894	15	-	28162770	HEL	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.24966666421830452	[477]	[363]	2	hSpCas9	negative selection	11700249
76338264	76338287	15	+	28162770	MV411	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	1.2145729168771486	[221]	[433]	9	hSpCas9	negative selection	11869613
76338348	76338371	15	-	28162770	MV411	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	0.8789426374409617	[121]	[188]	7	hSpCas9	negative selection	11869614
76337871	76337894	15	-	28162770	MV411	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.5857356067779094	[332]	[420]	5	hSpCas9	negative selection	11869615
76338264	76338287	15	+	28162770	MONOMAC1	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	0.7704372494189989	[156]	[306]	7	hSpCas9	negative selection	12038979
76338348	76338371	15	-	28162770	MONOMAC1	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	-0.47165922716855935	[74]	[61]	-4	hSpCas9	negative selection	12038980
76337871	76337894	15	-	28162770	MONOMAC1	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.5670748891197754	[178]	[303]	5	hSpCas9	negative selection	12038981
76338264	76338287	15	+	28162770	OCIAML2	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	0.294185551850918	[58]	[400]	3	hSpCas9	negative selection	12208345
76338348	76338371	15	-	28162770	OCIAML2	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	-0.011198206604863932	[35]	[197]	0	hSpCas9	negative selection	12208346
76337871	76337894	15	-	28162770	OCIAML2	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.5973469685738457	[56]	[477]	6	hSpCas9	negative selection	12208347
76338264	76338287	15	+	28162770	OCIAML3	viability	CAAGTGCGCCAAGTGCCAGGTGG	ISL2	ENSG00000159556	1.2068922595961415	[63]	[445]	8	hSpCas9	negative selection	12377711
76338348	76338371	15	-	28162770	OCIAML3	viability	GGCGGCTGCACACGGAGCAGCGG	ISL2	ENSG00000159556	1.0754051821963044	[46]	[298]	8	hSpCas9	negative selection	12377712
76337871	76337894	15	-	28162770	OCIAML3	viability	GCACTCGGCACACTTGAGGCAGG	ISL2	ENSG00000159556	0.11613416576633284	[113]	[372]	1	hSpCas9	negative selection	12377713