| 157245916 | 157245939 | 5 | + | 26472758 | Jiyoye | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | -0.3556192025121915 | [262] | [154] | -3 | hSpCas9 | negative selection | 79876 | 157240154 | 157240177 | 5 | - | 26472758 | Jiyoye | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | -0.2260422878225039 | [379] | [244] | -2 | hSpCas9 | negative selection | 79877 | 157243727 | 157243750 | 5 | + | 26472758 | Jiyoye | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | 0.23598873149964963 | [142] | [126] | 1 | hSpCas9 | negative selection | 79878 | 157244360 | 157244383 | 5 | + | 26472758 | Jiyoye | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | -0.6923602920450409 | [59] | [27] | -5 | hSpCas9 | negative selection | 79879 | 157248896 | 157248919 | 5 | + | 26472758 | Jiyoye | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | -1.192433895179684 | [296] | [97] | -7 | hSpCas9 | negative selection | 79880 | 157244292 | 157244315 | 5 | + | 26472758 | Jiyoye | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | 3.214530303563477 | [0] | [6] | 9 | hSpCas9 | negative selection | 79881 | 157244433 | 157244456 | 5 | + | 26472758 | Jiyoye | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | -0.24490131507382018 | [32] | [20] | -2 | hSpCas9 | negative selection | 79882 | 157245916 | 157245939 | 5 | + | 26472758 | KBM7 | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | -0.7558686976644824 | [882,613] | [250,164] | -6 | hSpCas9 | negative selection | 270994 | 157240154 | 157240177 | 5 | - | 26472758 | KBM7 | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 0.3015534646906881 | [1366,790] | [870,378] | 3 | hSpCas9 | negative selection | 270995 | 157243727 | 157243750 | 5 | + | 26472758 | KBM7 | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | 0.1738524574972955 | [379,228] | [229,93] | 1 | hSpCas9 | negative selection | 270996 | 157244360 | 157244383 | 5 | + | 26472758 | KBM7 | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | -0.4430589859833125 | [99,118] | [30,44] | -4 | hSpCas9 | negative selection | 270997 | 157248896 | 157248919 | 5 | + | 26472758 | KBM7 | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | 0.3126602047635823 | [633,598] | [516,220] | 3 | hSpCas9 | negative selection | 270998 | 157244292 | 157244315 | 5 | + | 26472758 | KBM7 | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | -0.043690169373280074 | [91,78] | [40,36] | 0 | hSpCas9 | negative selection | 270999 | 157244433 | 157244456 | 5 | + | 26472758 | KBM7 | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | -0.018684683030686933 | [337,274] | [113,165] | 0 | hSpCas9 | negative selection | 271000 | 157245916 | 157245939 | 5 | + | 26472758 | Raji | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | -0.2932565355278034 | [564] | [106] | -2 | hSpCas9 | negative selection | 462112 | 157240154 | 157240177 | 5 | - | 26472758 | Raji | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 0.8663754358698047 | [415] | [175] | 7 | hSpCas9 | negative selection | 462113 | 157243727 | 157243750 | 5 | + | 26472758 | Raji | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | 0.5521683780464952 | [143] | [48] | 5 | hSpCas9 | negative selection | 462114 | 157244360 | 157244383 | 5 | + | 26472758 | Raji | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | 3.005503921354386 | [21] | [40] | 9 | hSpCas9 | negative selection | 462115 | 157248896 | 157248919 | 5 | + | 26472758 | Raji | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | -0.5485007512781741 | [270] | [42] | -4 | hSpCas9 | negative selection | 462116 | 157244292 | 157244315 | 5 | + | 26472758 | Raji | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | -1.0355744184684434 | [52] | [5] | -6 | hSpCas9 | negative selection | 462117 | 157244433 | 157244456 | 5 | + | 26472758 | Raji | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | -0.4437906518912733 | [210] | [35] | -4 | hSpCas9 | negative selection | 462118 | 157245916 | 157245939 | 5 | + | 26472758 | K562 | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | 1.4232218804552117 | [647] | [1466] | 9 | hSpCas9 | negative selection | 653230 | 157240154 | 157240177 | 5 | - | 26472758 | K562 | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 0.4638144177933363 | [894] | [1041] | 3 | hSpCas9 | negative selection | 653231 | 157243727 | 157243750 | 5 | + | 26472758 | K562 | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | 0.9744566012415831 | [166] | [276] | 7 | hSpCas9 | negative selection | 653232 | 157244360 | 157244383 | 5 | + | 26472758 | K562 | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | 0.6767342183771263 | [82] | [111] | 5 | hSpCas9 | negative selection | 653233 | 157248896 | 157248919 | 5 | + | 26472758 | K562 | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | -0.513434232973583 | [486] | [287] | -3 | hSpCas9 | negative selection | 653234 | 157244292 | 157244315 | 5 | + | 26472758 | K562 | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | 1.5168781462895096 | [88] | [214] | 9 | hSpCas9 | negative selection | 653235 | 157244433 | 157244456 | 5 | + | 26472758 | K562 | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | 0.6064378446457996 | [290] | [373] | 5 | hSpCas9 | negative selection | 653236 | 157181084 | 157181107 | 5 | - | 26627737 | DLD1 | viability | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.8714984785025511 | [185] | [92,179,56] | 8 | hSpCas9 | negative selection | 827767 | 157241642 | 157241665 | 5 | - | 26627737 | DLD1 | viability | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 0.4073205493530321 | [1142] | [570,470,391] | 4 | hSpCas9 | negative selection | 827768 | 157181084 | 157181107 | 5 | - | 26627737 | GBM cells | viability after 5 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.293390051682213 | [158] | [91,116] | 4 | hSpCas9 | negative selection | 910082 | 157241642 | 157241665 | 5 | - | 26627737 | GBM cells | viability after 5 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 0.3146203725724779 | [538] | [419,298] | 5 | hSpCas9 | negative selection | 910083 | 157181084 | 157181107 | 5 | - | 26627737 | GBM cells | viability after 13 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.7571543841599627 | [158] | [179,117] | 8 | hSpCas9 | negative selection | 992397 | 157241642 | 157241665 | 5 | - | 26627737 | GBM cells | viability after 13 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 0.1799304382128999 | [538] | [445,237] | 2 | hSpCas9 | negative selection | 992398 | 157181084 | 157181107 | 5 | - | 26627737 | GBM cells | viability after 21 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.7474805200934924 | [158] | [167,123] | 7 | hSpCas9 | negative selection | 1074712 | 157241642 | 157241665 | 5 | - | 26627737 | GBM cells | viability after 21 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | -0.10768345906618793 | [538] | [288,255] | -1 | hSpCas9 | negative selection | 1074713 | 157181084 | 157181107 | 5 | - | 26627737 | RPE1 | viability after 9 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 1.2634676513296839 | [145] | [100,120] | 7 | hSpCas9 | negative selection | 1157027 | 157241642 | 157241665 | 5 | - | 26627737 | RPE1 | viability after 9 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | -0.2528869553309576 | [2395] | [415,904] | -2 | hSpCas9 | negative selection | 1157028 | 157181084 | 157181107 | 5 | - | 26627737 | RPE1 | viability after 12 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 1.3197343123673286 | [145] | [111,82] | 7 | hSpCas9 | negative selection | 1239342 | 157241642 | 157241665 | 5 | - | 26627737 | RPE1 | viability after 12 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | -0.08061165231848655 | [2395] | [667,545] | 0 | hSpCas9 | negative selection | 1239343 | 157181084 | 157181107 | 5 | - | 26627737 | RPE1 | viability after 15 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 1.4263107754933864 | [145] | [82,137] | 7 | hSpCas9 | negative selection | 1321657 | 157241642 | 157241665 | 5 | - | 26627737 | RPE1 | viability after 15 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 0.3865179894749937 | [2395] | [1025,750] | 2 | hSpCas9 | negative selection | 1321658 | 157181084 | 157181107 | 5 | - | 26627737 | RPE1 | viability after 18 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 1.3247041089176521 | [145] | [45,154] | 7 | hSpCas9 | negative selection | 1403972 | 157241642 | 157241665 | 5 | - | 26627737 | RPE1 | viability after 18 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 0.08130849282781005 | [2395] | [613,758] | 0 | hSpCas9 | negative selection | 1403973 | 157181084 | 157181107 | 5 | - | 26627737 | HeLa | viability after 8 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.8622424510062157 | [123] | [152,64,88] | 7 | hSpCas9 | negative selection | 1486287 | 157241642 | 157241665 | 5 | - | 26627737 | HeLa | viability after 8 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 1.10577269317238 | [826] | [697,988,629] | 8 | hSpCas9 | negative selection | 1486288 | 157181084 | 157181107 | 5 | - | 26627737 | HeLa | viability after 12 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 1.300511904539621 | [123] | [219,129,30] | 8 | hSpCas9 | negative selection | 1568602 | 157241642 | 157241665 | 5 | - | 26627737 | HeLa | viability after 12 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 1.440024164892748 | [826] | [1148,760,895] | 8 | hSpCas9 | negative selection | 1568603 | 157181084 | 157181107 | 5 | - | 26627737 | HeLa | viability after 15 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.5749343312517095 | [123] | [106,20,98] | 4 | hSpCas9 | negative selection | 1650917 | 157241642 | 157241665 | 5 | - | 26627737 | HeLa | viability after 15 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 1.3913610434876813 | [826] | [909,1087,631] | 8 | hSpCas9 | negative selection | 1650918 | 157181084 | 157181107 | 5 | - | 26627737 | HeLa | viability after 18 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.5399488421080472 | [123] | [66,18,98] | 4 | hSpCas9 | negative selection | 1733232 | 157241642 | 157241665 | 5 | - | 26627737 | HeLa | viability after 18 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 1.3959775002366093 | [826] | [627,885,631] | 8 | hSpCas9 | negative selection | 1733233 | 157181084 | 157181107 | 5 | - | 26627737 | HCT116 | viability after 6 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | -0.46304143507709905 | [406] | [77,28] | -3 | hSpCas9 | negative selection | 1815547 | 157241642 | 157241665 | 5 | - | 26627737 | HCT116 | viability after 6 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 2.1372003103343955 | [1094] | [1308,452] | 9 | hSpCas9 | negative selection | 1815548 | 157181084 | 157181107 | 5 | - | 26627737 | HCT116 | viability after 8 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | -0.1555656994364646 | [198] | [79,115,98] | -2 | hSpCas9 | negative selection | 1897862 | 157241642 | 157241665 | 5 | - | 26627737 | HCT116 | viability after 8 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 0.5965291562102762 | [591] | [459,347,668] | 6 | hSpCas9 | negative selection | 1897863 | 157181084 | 157181107 | 5 | - | 26627737 | HCT116 | viability after 9 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | -0.6589541163397732 | [406] | [17,108] | -5 | hSpCas9 | negative selection | 1980177 | 157241642 | 157241665 | 5 | - | 26627737 | HCT116 | viability after 9 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 0.8670464915292326 | [1094] | [396,640] | 6 | hSpCas9 | negative selection | 1980178 | 157181084 | 157181107 | 5 | - | 26627737 | HCT116 | viability after 12 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | -0.37777467272206156 | [198] | [49,115,78] | -4 | hSpCas9 | negative selection | 2062492 | 157241642 | 157241665 | 5 | - | 26627737 | HCT116 | viability after 12 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 0.9790579884100666 | [591] | [680,496,652] | 8 | hSpCas9 | negative selection | 2062493 | 157181084 | 157181107 | 5 | - | 26627737 | HCT116 | viability after 15 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | -0.22269740208276412 | [198] | [201,49,54] | -2 | hSpCas9 | negative selection | 2144807 | 157241642 | 157241665 | 5 | - | 26627737 | HCT116 | viability after 15 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 1.0669112405669376 | [591] | [845,593,712] | 8 | hSpCas9 | negative selection | 2144808 | 157181084 | 157181107 | 5 | - | 26627737 | HCT116 | viability after 18 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | -0.13806669609394917 | [198] | [102,91,65] | -1 | hSpCas9 | negative selection | 2227122 | 157241642 | 157241665 | 5 | - | 26627737 | HCT116 | viability after 18 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 1.2152815215153514 | [591] | [841,647,496] | 8 | hSpCas9 | negative selection | 2227123 | 157180977 | 157181000 | 5 | + | 24336569 | HL60 | viability | CATGAACAACTTTATCCTCCTGG | ITK | ENSG00000113263 | -0.8122050742544741 | [423] | [510] | -6 | hSpCas9 | negative selection | 2272403 | 157180992 | 157181015 | 5 | - | 24336569 | HL60 | viability | TGATGAGCTGTTCTTCCAGGAGG | ITK | ENSG00000113263 | 0.3899694544618457 | [554] | [1538] | 3 | hSpCas9 | negative selection | 2272404 | 157181044 | 157181067 | 5 | - | 24336569 | HL60 | viability | AAGCGGACTTTAAAGTTCGAGGG | ITK | ENSG00000113263 | 0.5101621303732706 | [287] | [867] | 4 | hSpCas9 | negative selection | 2272405 | 157181061 | 157181084 | 5 | - | 24336569 | HL60 | viability | CTTTGGTTAACACAAAGAAGCGG | ITK | ENSG00000113263 | -0.25734059952304095 | [500] | [886] | -2 | hSpCas9 | negative selection | 2272406 | 157181070 | 157181093 | 5 | + | 24336569 | HL60 | viability | TGTGTTAACCAAAGCCAGCCTGG | ITK | ENSG00000113263 | 0.35114022541458073 | [601] | [1624] | 3 | hSpCas9 | negative selection | 2272407 | 157181078 | 157181101 | 5 | - | 24336569 | HL60 | viability | AAAGTATGCCAGGCTGGCTTTGG | ITK | ENSG00000113263 | 0.7797011205413069 | [514] | [1870] | 6 | hSpCas9 | negative selection | 2272408 | 157181084 | 157181107 | 5 | - | 24336569 | HL60 | viability | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | -0.18405296067278643 | [793] | [1478] | -1 | hSpCas9 | negative selection | 2272409 | 157181092 | 157181115 | 5 | + | 24336569 | HL60 | viability | GCATACTTTGAAGATCGTCATGG | ITK | ENSG00000113263 | 0.5372691367475039 | [379] | [1166] | 5 | hSpCas9 | negative selection | 2272410 | 157180977 | 157181000 | 5 | + | 24336569 | KBM7 | viability | CATGAACAACTTTATCCTCCTGG | ITK | ENSG00000113263 | 0.21957693108457166 | [198] | [631] | 2 | hSpCas9 | negative selection | 2339580 | 157180992 | 157181015 | 5 | - | 24336569 | KBM7 | viability | TGATGAGCTGTTCTTCCAGGAGG | ITK | ENSG00000113263 | -0.4956734847499276 | [548] | [1061] | -4 | hSpCas9 | negative selection | 2339581 | 157181044 | 157181067 | 5 | - | 24336569 | KBM7 | viability | AAGCGGACTTTAAAGTTCGAGGG | ITK | ENSG00000113263 | 1.3289609051581697 | [168] | [1157] | 9 | hSpCas9 | negative selection | 2339582 | 157181061 | 157181084 | 5 | - | 24336569 | KBM7 | viability | CTTTGGTTAACACAAAGAAGCGG | ITK | ENSG00000113263 | 0.42993679692612263 | [300] | [1105] | 4 | hSpCas9 | negative selection | 2339583 | 157181070 | 157181093 | 5 | + | 24336569 | KBM7 | viability | TGTGTTAACCAAAGCCAGCCTGG | ITK | ENSG00000113263 | 0.7902007941140143 | [412] | [1947] | 7 | hSpCas9 | negative selection | 2339584 | 157181078 | 157181101 | 5 | - | 24336569 | KBM7 | viability | AAAGTATGCCAGGCTGGCTTTGG | ITK | ENSG00000113263 | 0.6373893353511711 | [646] | [2744] | 6 | hSpCas9 | negative selection | 2339585 | 157181084 | 157181107 | 5 | - | 24336569 | KBM7 | viability | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.6779516855349764 | [461] | [2015] | 6 | hSpCas9 | negative selection | 2339586 | 157181092 | 157181115 | 5 | + | 24336569 | KBM7 | viability | GCATACTTTGAAGATCGTCATGG | ITK | ENSG00000113263 | 0.6457428535856162 | [317] | [1356] | 6 | hSpCas9 | negative selection | 2339587 | 157144533 | 157144556 | 5 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TCACTGCAAGCTCCACCTCCCAG | ITK | ENSG00000113263 | -1.3954490623194618 | [659,580] | [75,24] | -7 | dCas9-VP64 | positive selection | 2391061 | 157142933 | 157142956 | 5 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CGGAGCTAGAATTTCGTTAAAGG | ITK | ENSG00000113263 | 0.11322158221079892 | [1,12] | [1,0] | 0 | dCas9-VP64 | positive selection | 2396170 | 157224663 | 157224686 | 5 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TCCAGCTACTCGGGAGGCTGGGG | ITK | ENSG00000113263 | -0.3263248793387761 | [5,18] | [1,1] | -1 | dCas9-VP64 | positive selection | 2433402 | 157143020 | 157143043 | 5 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | ACTTTTAAAAGTCGTAGCTGAGG | ITK | ENSG00000113263 | 1.5297882564859253 | [86,65] | [83,9] | 6 | dCas9-VP64 | positive selection | 2435463 | 157142982 | 157143005 | 5 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GGGAGGAGTCAAACATACGTAGG | ITK | ENSG00000113263 | 1.3577952181053365 | [20,50] | [22,16] | 5 | dCas9-VP64 | positive selection | 2435464 | 157142999 | 157143022 | 5 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GTCAGTAACGGGTGGATGGGAGG | ITK | ENSG00000113263 | -0.5161576991259198 | [12,42] | [3,3] | -3 | dCas9-VP64 | positive selection | 2435465 | 157180711 | 157180734 | 5 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | ATACATACAGCCTTTGCTAATGG | ITK | ENSG00000113263 | 0.6792823324806603 | [30,75] | [25,9] | 3 | dCas9-VP64 | positive selection | 2438261 | 157180778 | 157180801 | 5 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GTTTCGGCCTTTGACATCAGAGG | ITK | ENSG00000113263 | 1.009156748385725 | [370,126] | [70,150] | 4 | dCas9-VP64 | positive selection | 2438262 | 157180756 | 157180779 | 5 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TTGTGAATTTTGAAAGGATGTGG | ITK | ENSG00000113263 | 2.536405736667832 | [156,185] | [40,411] | 8 | dCas9-VP64 | positive selection | 2438263 | 157166382 | 157166405 | 5 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | ATTGATTTGTTTTGTGGGGGAGG | ITK | ENSG00000113263 | 1.4379066073106253 | [161,158] | [35,159] | 5 | dCas9-VP64 | positive selection | 2463290 | 157166360 | 157166383 | 5 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GCTGGTGACACTGACCAGAGGGG | ITK | ENSG00000113263 | -0.3812618704803594 | [95,14] | [12,3] | -2 | dCas9-VP64 | positive selection | 2463291 | 157166406 | 157166429 | 5 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GGTCAGCCTCTCCCCTGTGGAGG | ITK | ENSG00000113263 | 2.680834394789609 | [10,1] | [5,11] | 8 | dCas9-VP64 | positive selection | 2463292 | 157144533 | 157144556 | 5 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TCACTGCAAGCTCCACCTCCCAG | ITK | ENSG00000113263 | 0.22022123063307442 | [237,267] | [67,121] | 1 | dCas9-VP64 | positive selection | 2486316 | 157142933 | 157142956 | 5 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CGGAGCTAGAATTTCGTTAAAGG | ITK | ENSG00000113263 | -0.03850343390170119 | [17,72] | [12,13] | 0 | dCas9-VP64 | positive selection | 2491425 | 157224663 | 157224686 | 5 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TCCAGCTACTCGGGAGGCTGGGG | ITK | ENSG00000113263 | 0.03970496149462466 | [46,104] | [37,12] | 0 | dCas9-VP64 | positive selection | 2528657 | 157143020 | 157143043 | 5 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | ACTTTTAAAAGTCGTAGCTGAGG | ITK | ENSG00000113263 | 0.3467080225438648 | [89,108] | [38,42] | 2 | dCas9-VP64 | positive selection | 2530718 | 157142982 | 157143005 | 5 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GGGAGGAGTCAAACATACGTAGG | ITK | ENSG00000113263 | -0.3831352465506288 | [18,76] | [6,14] | -4 | dCas9-VP64 | positive selection | 2530719 | 157142999 | 157143022 | 5 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GTCAGTAACGGGTGGATGGGAGG | ITK | ENSG00000113263 | -0.4309741768905121 | [72,63] | [16,14] | -4 | dCas9-VP64 | positive selection | 2530720 | 157180711 | 157180734 | 5 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | ATACATACAGCCTTTGCTAATGG | ITK | ENSG00000113263 | -0.52523264809288 | [164,123] | [25,38] | -5 | dCas9-VP64 | positive selection | 2533516 | 157180778 | 157180801 | 5 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GTTTCGGCCTTTGACATCAGAGG | ITK | ENSG00000113263 | 0.6368619312843184 | [93,68] | [25,54] | 5 | dCas9-VP64 | positive selection | 2533517 | 157180756 | 157180779 | 5 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TTGTGAATTTTGAAAGGATGTGG | ITK | ENSG00000113263 | -0.07509473646381393 | [81,199] | [32,52] | 0 | dCas9-VP64 | positive selection | 2533518 | 157166382 | 157166405 | 5 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | ATTGATTTGTTTTGTGGGGGAGG | ITK | ENSG00000113263 | -0.21368275831593742 | [143,60] | [33,23] | -2 | dCas9-VP64 | positive selection | 2558545 | 157166360 | 157166383 | 5 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GCTGGTGACACTGACCAGAGGGG | ITK | ENSG00000113263 | -0.1362895143180869 | [49,47] | [8,18] | -1 | dCas9-VP64 | positive selection | 2558546 | 157166406 | 157166429 | 5 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GGTCAGCCTCTCCCCTGTGGAGG | ITK | ENSG00000113263 | 1.965421127422595 | [87,172] | [80,244] | 8 | dCas9-VP64 | positive selection | 2558547 | 157181070 | 157181093 | 5 | + | 27260157 | DLD1 | viability | TGTGTTAACCAAAGCCAGCCTGG | ITK | ENSG00000113263 | 0.547120757803791 | [] | [] | 8 | hSpCas9 | negative selection | 2578298 | 157181061 | 157181084 | 5 | - | 27260157 | DLD1 | viability | CTTTGGTTAACACAAAGAAGCGG | ITK | ENSG00000113263 | -0.413091136326034 | [] | [] | -3 | hSpCas9 | negative selection | 2581491 | 157180977 | 157181000 | 5 | + | 27260157 | DLD1 | viability | CATGAACAACTTTATCCTCCTGG | ITK | ENSG00000113263 | 0.837242604384918 | [] | [] | 9 | hSpCas9 | negative selection | 2582123 | 157181044 | 157181067 | 5 | - | 27260157 | DLD1 | viability | AAGCGGACTTTAAAGTTCGAGGG | ITK | ENSG00000113263 | 0.876944936154859 | [] | [] | 9 | hSpCas9 | negative selection | 2587650 | 157240114 | 157240137 | 5 | - | 27260157 | DLD1 | viability | TCAGCCACATAGTATCGCTTAGG | ITK | ENSG00000113263 | -0.294431125011332 | [] | [] | -2 | hSpCas9 | negative selection | 2610386 | 157180992 | 157181015 | 5 | - | 27260157 | DLD1 | viability | TGATGAGCTGTTCTTCCAGGAGG | ITK | ENSG00000113263 | 0.765849494717657 | [] | [] | 8 | hSpCas9 | negative selection | 2613913 | 157181092 | 157181115 | 5 | + | 27260157 | DLD1 | viability | GCATACTTTGAAGATCGTCATGG | ITK | ENSG00000113263 | 0.369369500181355 | [] | [] | 4 | hSpCas9 | negative selection | 2617299 | 157238122 | 157238145 | 5 | + | 27260157 | DLD1 | viability | CCTTCATGGTAAGGGATTCCAGG | ITK | ENSG00000113263 | -0.2789833325009 | [] | [] | -2 | hSpCas9 | negative selection | 2619633 | 157241643 | 157241666 | 5 | + | 27260157 | DLD1 | viability | CAGGCCTGGTGACTCGACTCCGG | ITK | ENSG00000113263 | -0.0798020307440048 | [] | [] | 0 | hSpCas9 | negative selection | 2622426 | 157181088 | 157181111 | 5 | - | 27260157 | DLD1 | viability | GACGATCTTCAAAGTATGCCAGG | ITK | ENSG00000113263 | 0.864719267029413 | [] | [] | 9 | hSpCas9 | negative selection | 2622445 | 157181084 | 157181107 | 5 | - | 27260157 | DLD1 | viability | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | -0.0105790672514678 | [] | [] | 0 | hSpCas9 | negative selection | 2623376 | 157181078 | 157181101 | 5 | - | 27260157 | DLD1 | viability | AAAGTATGCCAGGCTGGCTTTGG | ITK | ENSG00000113263 | 0.549679487840206 | [] | [] | 8 | hSpCas9 | negative selection | 2648664 | 157181070 | 157181093 | 5 | + | 27260157 | HT1080 | viability | TGTGTTAACCAAAGCCAGCCTGG | ITK | ENSG00000113263 | -0.378970642942554 | [] | [] | -7 | hSpCas9 | negative selection | 2654428 | 157181061 | 157181084 | 5 | - | 27260157 | HT1080 | viability | CTTTGGTTAACACAAAGAAGCGG | ITK | ENSG00000113263 | -0.62971726500345 | [] | [] | -8 | hSpCas9 | negative selection | 2657621 | 157180977 | 157181000 | 5 | + | 27260157 | HT1080 | viability | CATGAACAACTTTATCCTCCTGG | ITK | ENSG00000113263 | 0.118508349749714 | [] | [] | 1 | hSpCas9 | negative selection | 2658253 | 157181044 | 157181067 | 5 | - | 27260157 | HT1080 | viability | AAGCGGACTTTAAAGTTCGAGGG | ITK | ENSG00000113263 | 1.00143377746523 | [] | [] | 8 | hSpCas9 | negative selection | 2663780 | 157240114 | 157240137 | 5 | - | 27260157 | HT1080 | viability | TCAGCCACATAGTATCGCTTAGG | ITK | ENSG00000113263 | -0.0912359129889033 | [] | [] | 0 | hSpCas9 | negative selection | 2686516 | 157180992 | 157181015 | 5 | - | 27260157 | HT1080 | viability | TGATGAGCTGTTCTTCCAGGAGG | ITK | ENSG00000113263 | 0.475468661411988 | [] | [] | 4 | hSpCas9 | negative selection | 2690043 | 157181092 | 157181115 | 5 | + | 27260157 | HT1080 | viability | GCATACTTTGAAGATCGTCATGG | ITK | ENSG00000113263 | 1.03975550763038 | [] | [] | 8 | hSpCas9 | negative selection | 2693429 | 157238122 | 157238145 | 5 | + | 27260157 | HT1080 | viability | CCTTCATGGTAAGGGATTCCAGG | ITK | ENSG00000113263 | 0.516928981520878 | [] | [] | 4 | hSpCas9 | negative selection | 2695763 | 157241643 | 157241666 | 5 | + | 27260157 | HT1080 | viability | CAGGCCTGGTGACTCGACTCCGG | ITK | ENSG00000113263 | -0.0832673287237294 | [] | [] | 0 | hSpCas9 | negative selection | 2698556 | 157181088 | 157181111 | 5 | - | 27260157 | HT1080 | viability | GACGATCTTCAAAGTATGCCAGG | ITK | ENSG00000113263 | 1.39331267439075 | [] | [] | 9 | hSpCas9 | negative selection | 2698575 | 157181084 | 157181107 | 5 | - | 27260157 | HT1080 | viability | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.247430997585277 | [] | [] | 2 | hSpCas9 | negative selection | 2699506 | 157181078 | 157181101 | 5 | - | 27260157 | HT1080 | viability | AAAGTATGCCAGGCTGGCTTTGG | ITK | ENSG00000113263 | -0.747557985380104 | [] | [] | -8 | hSpCas9 | negative selection | 2724794 | 157181070 | 157181093 | 5 | + | 27260157 | MKN45 | viability | TGTGTTAACCAAAGCCAGCCTGG | ITK | ENSG00000113263 | -0.109281060442613 | [] | [] | 0 | hSpCas9 | negative selection | 2730558 | 157181061 | 157181084 | 5 | - | 27260157 | MKN45 | viability | CTTTGGTTAACACAAAGAAGCGG | ITK | ENSG00000113263 | -0.668511157271352 | [] | [] | -7 | hSpCas9 | negative selection | 2733751 | 157180977 | 157181000 | 5 | + | 27260157 | MKN45 | viability | CATGAACAACTTTATCCTCCTGG | ITK | ENSG00000113263 | 0.779630213842935 | [] | [] | 7 | hSpCas9 | negative selection | 2734383 | 157181044 | 157181067 | 5 | - | 27260157 | MKN45 | viability | AAGCGGACTTTAAAGTTCGAGGG | ITK | ENSG00000113263 | 0.46112471974125 | [] | [] | 6 | hSpCas9 | negative selection | 2739910 | 157240114 | 157240137 | 5 | - | 27260157 | MKN45 | viability | TCAGCCACATAGTATCGCTTAGG | ITK | ENSG00000113263 | -1.33106619432185 | [] | [] | -8 | hSpCas9 | negative selection | 2762646 | 157180992 | 157181015 | 5 | - | 27260157 | MKN45 | viability | TGATGAGCTGTTCTTCCAGGAGG | ITK | ENSG00000113263 | 0.0338659979710518 | [] | [] | 0 | hSpCas9 | negative selection | 2766173 | 157181092 | 157181115 | 5 | + | 27260157 | MKN45 | viability | GCATACTTTGAAGATCGTCATGG | ITK | ENSG00000113263 | 0.70846848818593 | [] | [] | 7 | hSpCas9 | negative selection | 2769559 | 157238122 | 157238145 | 5 | + | 27260157 | MKN45 | viability | CCTTCATGGTAAGGGATTCCAGG | ITK | ENSG00000113263 | -0.181292597778671 | [] | [] | 0 | hSpCas9 | negative selection | 2771893 | 157241643 | 157241666 | 5 | + | 27260157 | MKN45 | viability | CAGGCCTGGTGACTCGACTCCGG | ITK | ENSG00000113263 | -0.23757330435758 | [] | [] | -1 | hSpCas9 | negative selection | 2774686 | 157181088 | 157181111 | 5 | - | 27260157 | MKN45 | viability | GACGATCTTCAAAGTATGCCAGG | ITK | ENSG00000113263 | 1.54946671786998 | [] | [] | 9 | hSpCas9 | negative selection | 2774705 | 157181084 | 157181107 | 5 | - | 27260157 | MKN45 | viability | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.247418391428881 | [] | [] | 5 | hSpCas9 | negative selection | 2775636 | 157181078 | 157181101 | 5 | - | 27260157 | MKN45 | viability | AAAGTATGCCAGGCTGGCTTTGG | ITK | ENSG00000113263 | 0.486238643992781 | [] | [] | 6 | hSpCas9 | negative selection | 2800924 | 157181070 | 157181093 | 5 | + | 27260157 | RKO | viability | TGTGTTAACCAAAGCCAGCCTGG | ITK | ENSG00000113263 | 0.389001327734296 | [] | [] | 2 | hSpCas9 | negative selection | 2806688 | 157181061 | 157181084 | 5 | - | 27260157 | RKO | viability | CTTTGGTTAACACAAAGAAGCGG | ITK | ENSG00000113263 | -0.350191654278313 | [] | [] | -6 | hSpCas9 | negative selection | 2809881 | 157180977 | 157181000 | 5 | + | 27260157 | RKO | viability | CATGAACAACTTTATCCTCCTGG | ITK | ENSG00000113263 | 0.445345458067417 | [] | [] | 2 | hSpCas9 | negative selection | 2810513 | 157181044 | 157181067 | 5 | - | 27260157 | RKO | viability | AAGCGGACTTTAAAGTTCGAGGG | ITK | ENSG00000113263 | 0.581495943011566 | [] | [] | 3 | hSpCas9 | negative selection | 2816040 | 157240114 | 157240137 | 5 | - | 27260157 | RKO | viability | TCAGCCACATAGTATCGCTTAGG | ITK | ENSG00000113263 | 0.245235904065059 | [] | [] | 1 | hSpCas9 | negative selection | 2838776 | 157180992 | 157181015 | 5 | - | 27260157 | RKO | viability | TGATGAGCTGTTCTTCCAGGAGG | ITK | ENSG00000113263 | -0.019885844130663 | [] | [] | 0 | hSpCas9 | negative selection | 2842303 | 157181092 | 157181115 | 5 | + | 27260157 | RKO | viability | GCATACTTTGAAGATCGTCATGG | ITK | ENSG00000113263 | 1.15599146974507 | [] | [] | 9 | hSpCas9 | negative selection | 2845689 | 157238122 | 157238145 | 5 | + | 27260157 | RKO | viability | CCTTCATGGTAAGGGATTCCAGG | ITK | ENSG00000113263 | -0.11322656072112 | [] | [] | 0 | hSpCas9 | negative selection | 2848023 | 157241643 | 157241666 | 5 | + | 27260157 | RKO | viability | CAGGCCTGGTGACTCGACTCCGG | ITK | ENSG00000113263 | 0.125190312619588 | [] | [] | 0 | hSpCas9 | negative selection | 2850816 | 157181088 | 157181111 | 5 | - | 27260157 | RKO | viability | GACGATCTTCAAAGTATGCCAGG | ITK | ENSG00000113263 | 1.52045258117526 | [] | [] | 9 | hSpCas9 | negative selection | 2850835 | 157181084 | 157181107 | 5 | - | 27260157 | RKO | viability | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 1.0676614873711 | [] | [] | 9 | hSpCas9 | negative selection | 2851766 | 157181078 | 157181101 | 5 | - | 27260157 | RKO | viability | AAAGTATGCCAGGCTGGCTTTGG | ITK | ENSG00000113263 | 0.616780389463963 | [] | [] | 3 | hSpCas9 | negative selection | 2877054 | 157181070 | 157181093 | 5 | + | 27260157 | SF268 | viability | TGTGTTAACCAAAGCCAGCCTGG | ITK | ENSG00000113263 | 0.878729617469715 | [] | [] | 9 | hSpCas9 | negative selection | 2882818 | 157181061 | 157181084 | 5 | - | 27260157 | SF268 | viability | CTTTGGTTAACACAAAGAAGCGG | ITK | ENSG00000113263 | 0.17966855063786 | [] | [] | 0 | hSpCas9 | negative selection | 2886011 | 157180977 | 157181000 | 5 | + | 27260157 | SF268 | viability | CATGAACAACTTTATCCTCCTGG | ITK | ENSG00000113263 | 0.4258390444595 | [] | [] | 4 | hSpCas9 | negative selection | 2886643 | 157181044 | 157181067 | 5 | - | 27260157 | SF268 | viability | AAGCGGACTTTAAAGTTCGAGGG | ITK | ENSG00000113263 | 0.61380763750523 | [] | [] | 8 | hSpCas9 | negative selection | 2892170 | 157240114 | 157240137 | 5 | - | 27260157 | SF268 | viability | TCAGCCACATAGTATCGCTTAGG | ITK | ENSG00000113263 | 0.010615848253727 | [] | [] | 0 | hSpCas9 | negative selection | 2914906 | 157180992 | 157181015 | 5 | - | 27260157 | SF268 | viability | TGATGAGCTGTTCTTCCAGGAGG | ITK | ENSG00000113263 | 0.78791358996271 | [] | [] | 8 | hSpCas9 | negative selection | 2918433 | 157181092 | 157181115 | 5 | + | 27260157 | SF268 | viability | GCATACTTTGAAGATCGTCATGG | ITK | ENSG00000113263 | 0.925380988882433 | [] | [] | 9 | hSpCas9 | negative selection | 2921819 | 157238122 | 157238145 | 5 | + | 27260157 | SF268 | viability | CCTTCATGGTAAGGGATTCCAGG | ITK | ENSG00000113263 | 0.533847929968941 | [] | [] | 8 | hSpCas9 | negative selection | 2924153 | 157241643 | 157241666 | 5 | + | 27260157 | SF268 | viability | CAGGCCTGGTGACTCGACTCCGG | ITK | ENSG00000113263 | 0.0106332392716104 | [] | [] | 0 | hSpCas9 | negative selection | 2926946 | 157181088 | 157181111 | 5 | - | 27260157 | SF268 | viability | GACGATCTTCAAAGTATGCCAGG | ITK | ENSG00000113263 | 1.30665833773349 | [] | [] | 9 | hSpCas9 | negative selection | 2926965 | 157181084 | 157181107 | 5 | - | 27260157 | SF268 | viability | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.435409675280884 | [] | [] | 7 | hSpCas9 | negative selection | 2927896 | 157181078 | 157181101 | 5 | - | 27260157 | SF268 | viability | AAAGTATGCCAGGCTGGCTTTGG | ITK | ENSG00000113263 | 0.241480854036202 | [] | [] | 3 | hSpCas9 | negative selection | 2953184 | 157181092 | 157181115 | 5 | + | 27013184 | SW480 | treatment with recombinant TRAIL | GCATACTTTGAAGATCGTCATGG | ITK | ENSG00000113263 | 0.4489586601009502 | [250,465] | [245,147] | 2 | hSpCas9 | positive selection | 2957851 | 157181093 | 157181116 | 5 | + | 27013184 | SW480 | treatment with recombinant TRAIL | CATACTTTGAAGATCGTCATGGG | ITK | ENSG00000113263 | -0.7488204653073602 | [113,131] | [44,11] | -3 | hSpCas9 | positive selection | 2957852 | 157181094 | 157181117 | 5 | + | 27013184 | SW480 | treatment with recombinant TRAIL | ATACTTTGAAGATCGTCATGGGG | ITK | ENSG00000113263 | 0.7656866008534862 | [46,56] | [62,1] | 4 | hSpCas9 | positive selection | 2957855 | 157180977 | 157181000 | 5 | + | 27013184 | SW480 | treatment with recombinant TRAIL | CATGAACAACTTTATCCTCCTGG | ITK | ENSG00000113263 | -0.38170488132289093 | [587,606] | [79,364] | -2 | hSpCas9 | positive selection | 2957858 | 157181061 | 157181084 | 5 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | CTTTGGTTAACACAAAGAAGCGG | ITK | ENSG00000113263 | -0.4259806546230847 | [2,2] | [3,0] | -6 | hSpCas9 | positive selection | 2996224 | 157180992 | 157181015 | 5 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | TGATGAGCTGTTCTTCCAGGAGG | ITK | ENSG00000113263 | -0.09505527186717425 | [4,4] | [4,2] | -1 | hSpCas9 | positive selection | 2996225 | 157181061 | 157181084 | 5 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | CTTTGGTTAACACAAAGAAGCGG | ITK | ENSG00000113263 | -0.5298294546060289 | [2,2] | [2,0] | -7 | hSpCas9 | positive selection | 3064082 | 157180992 | 157181015 | 5 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | TGATGAGCTGTTCTTCCAGGAGG | ITK | ENSG00000113263 | 0.001824272089322121 | [4,4] | [4,2] | 0 | hSpCas9 | positive selection | 3064083 | 157245970 | 157245993 | 5 | + | 27383988 | 293T | resistance to West Nile virus (flavivirus) | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.18561728440289318 | [173,173] | [0,0] | -1 | hSpCas9 | positive selection | 3374831 | 157245917 | 157245940 | 5 | + | 27383988 | 293T | resistance to West Nile virus (flavivirus) | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | 0.10757909194115295 | [141,141] | [0,0] | 0 | hSpCas9 | positive selection | 3374832 | 157181061 | 157181084 | 5 | - | 26780180 | HT29 | viability (Avana library 4 designs) | CTTTGGTTAACACAAAGAAGCGG | ITK | ENSG00000113263 | 2.00887962939592 | [] | [] | 7 | hSpCas9 | negative selection | 3433620 | 157180992 | 157181015 | 5 | - | 26780180 | HT29 | viability (Avana library 4 designs) | TGATGAGCTGTTCTTCCAGGAGG | ITK | ENSG00000113263 | 0.560014334741032 | [] | [] | 2 | hSpCas9 | negative selection | 3433621 | 157180992 | 157181015 | 5 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TGATGAGCTGTTCTTCCAGGAGG | ITK | ENSG00000113263 | 3.66622793434357 | [] | [] | 6 | hSpCas9 | negative selection | 3520319 | 157181061 | 157181084 | 5 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CTTTGGTTAACACAAAGAAGCGG | ITK | ENSG00000113263 | -2.53534953026618 | [] | [] | -3 | hSpCas9 | negative selection | 3520320 | 157181044 | 157181067 | 5 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | AAGCGGACTTTAAAGTTCGAGGG | ITK | ENSG00000113263 | 1.08881151293316 | [] | [] | 1 | hSpCas9 | negative selection | 3520321 | 157180992 | 157181015 | 5 | - | 26780180 | A375 | viability (Avana lentiGuide) | TGATGAGCTGTTCTTCCAGGAGG | ITK | ENSG00000113263 | -1.52025716522918 | [] | [] | -2 | hSpCas9 | negative selection | 3628978 | 157181061 | 157181084 | 5 | - | 26780180 | A375 | viability (Avana lentiGuide) | CTTTGGTTAACACAAAGAAGCGG | ITK | ENSG00000113263 | -2.62672057782716 | [] | [] | -5 | hSpCas9 | negative selection | 3628979 | 157181044 | 157181067 | 5 | - | 26780180 | A375 | viability (Avana lentiGuide) | AAGCGGACTTTAAAGTTCGAGGG | ITK | ENSG00000113263 | 0.957715670444398 | [] | [] | 1 | hSpCas9 | negative selection | 3628980 | 157180992 | 157181015 | 5 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TGATGAGCTGTTCTTCCAGGAGG | ITK | ENSG00000113263 | 0.046744714422008664 | [5] | [5,4] | 1 | hSpCas9 | positive selection | 3737637 | 157181061 | 157181084 | 5 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CTTTGGTTAACACAAAGAAGCGG | ITK | ENSG00000113263 | -0.655873478268052 | [5] | [5,1] | -7 | hSpCas9 | positive selection | 3737638 | 157181044 | 157181067 | 5 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | AAGCGGACTTTAAAGTTCGAGGG | ITK | ENSG00000113263 | 0.15075844838532618 | [5] | [5,5] | 4 | hSpCas9 | positive selection | 3737639 | 157180992 | 157181015 | 5 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TGATGAGCTGTTCTTCCAGGAGG | ITK | ENSG00000113263 | 0.1117679402965524 | [5] | [4,5] | 2 | hSpCas9 | positive selection | 3846244 | 157181061 | 157181084 | 5 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CTTTGGTTAACACAAAGAAGCGG | ITK | ENSG00000113263 | -0.2217450135102612 | [4] | [4,2] | -3 | hSpCas9 | positive selection | 3846245 | 157181044 | 157181067 | 5 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | AAGCGGACTTTAAAGTTCGAGGG | ITK | ENSG00000113263 | 0.09245766544039591 | [5] | [5,3] | 2 | hSpCas9 | positive selection | 3846246 | 157245970 | 157245993 | 5 | + | 26780180 | A375 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | 1.207742900644 | [] | [] | 6 | hSpCas9 | negative selection | 3952272 | 157245917 | 157245940 | 5 | + | 26780180 | A375 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | 1.49286005753672 | [] | [] | 8 | hSpCas9 | negative selection | 3952273 | 157245970 | 157245993 | 5 | + | 26780180 | HT29 | viability (GeCKOv2 library) | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | 1.3254412257421 | [] | [] | 6 | hSpCas9 | negative selection | 4060238 | 157245917 | 157245940 | 5 | + | 26780180 | HT29 | viability (GeCKOv2 library) | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | 1.59731649883095 | [] | [] | 8 | hSpCas9 | negative selection | 4060239 | 157245970 | 157245993 | 5 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | 0.0416131599966483 | [3] | [3,1] | 0 | hSpCas9 | positive selection | 4341754 | 157245917 | 157245940 | 5 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.02942382324898697 | [3] | [2,2] | 0 | hSpCas9 | positive selection | 4341755 | 157238176 | 157238198 | 5 | - | 27760321 | OCIAML3 | viability | CCATACCTTACAACAGCCTTGG | ITK | ENSG00000113263 | 0.23075108484829743 | [501,403] | [313,542] | 2 | hSpCas9 | negative selection | 4410635 | 157238176 | 157238198 | 5 | - | 27760321 | OCIAML2 | viability | CCATACCTTACAACAGCCTTGG | ITK | ENSG00000113263 | 0.4171549690414535 | [501,403] | [420,572] | 5 | hSpCas9 | negative selection | 4494098 | 157238176 | 157238198 | 5 | - | 27760321 | MV411 | viability | CCATACCTTACAACAGCCTTGG | ITK | ENSG00000113263 | 1.8264556074507694 | [501,403] | [1156,899] | 9 | hSpCas9 | negative selection | 4577561 | 157238176 | 157238198 | 5 | - | 27760321 | HL60 | viability | CCATACCTTACAACAGCCTTGG | ITK | ENSG00000113263 | 0.24503863772684858 | [501,403] | [372,502] | 3 | hSpCas9 | negative selection | 4661024 | 157238176 | 157238198 | 5 | - | 27760321 | HT1080 | viability | CCATACCTTACAACAGCCTTGG | ITK | ENSG00000113263 | 1.2575686184934312 | [403,314] | [297,390] | 6 | hSpCas9 | negative selection | 4744487 | 157238176 | 157238198 | 5 | - | 27760321 | HT29 | viability after 7 days | CCATACCTTACAACAGCCTTGG | ITK | ENSG00000113263 | 0.5478861609740174 | [403,314] | [519,779,702] | 8 | hSpCas9 | negative selection | 4827950 | 157238176 | 157238198 | 5 | - | 27760321 | HT29 | viability after 25 days | CCATACCTTACAACAGCCTTGG | ITK | ENSG00000113263 | 0.939037594813516 | [403,314] | [608,915,854] | 9 | hSpCas9 | negative selection | 4911413 | 157238176 | 157238198 | 5 | - | 27760321 | HT29 | viability after 22 days | CCATACCTTACAACAGCCTTGG | ITK | ENSG00000113263 | 0.813579413517322 | [403,314] | [811,642,733] | 8 | hSpCas9 | negative selection | 4994876 | 157238176 | 157238198 | 5 | - | 27760321 | HT29 | viability after 19 days | CCATACCTTACAACAGCCTTGG | ITK | ENSG00000113263 | 1.11337961009754 | [403,314] | [968,866,841] | 9 | hSpCas9 | negative selection | 5078339 | 157238176 | 157238198 | 5 | - | 27760321 | HT29 | viability after 16 days | CCATACCTTACAACAGCCTTGG | ITK | ENSG00000113263 | 0.5707246435054844 | [403,314] | [522,441,823] | 6 | hSpCas9 | negative selection | 5161802 | 157238176 | 157238198 | 5 | - | 27760321 | HT29 | viability after 13 days | CCATACCTTACAACAGCCTTGG | ITK | ENSG00000113263 | 0.6636857284017578 | [403,314] | [531,702,741] | 8 | hSpCas9 | negative selection | 5245265 | 157238176 | 157238198 | 5 | - | 27760321 | HT29 | viability after 10 days | CCATACCTTACAACAGCCTTGG | ITK | ENSG00000113263 | 0.7819634379622717 | [403,314] | [311,894,1103] | 9 | hSpCas9 | negative selection | 5328728 | 157238176 | 157238198 | 5 | - | 27760321 | MOLM13 | viability | CCATACCTTACAACAGCCTTGG | ITK | ENSG00000113263 | 1.0720319906083748 | [501,403] | [455,600] | 7 | hSpCas9 | negative selection | 5412191 | 157166266 | 157166289 | 5 | - | 27661255 | K562 | viability | GTGGTGGTGCCAGGAGATTTAGG | ITK | ENSG00000113263 | 0.0586346874710979 | [1501,1603] | [1378,1214] | 2 | dCas9-KRAB | negative selection | 5479234 | 157180930 | 157180953 | 5 | + | 27661255 | K562 | viability | GTGCTAAGAGGTGATGCCCAAGG | ITK | ENSG00000113263 | 0.20325412437848311 | [834,927] | [820,798] | 7 | dCas9-KRAB | negative selection | 5487457 | 157180887 | 157180910 | 5 | - | 27661255 | K562 | viability | GGGCAAAGAATGCAATGTGGAGG | ITK | ENSG00000113263 | 0.19490970476389208 | [835,694] | [779,635] | 6 | dCas9-KRAB | negative selection | 5487458 | 157245970 | 157245993 | 5 | + | 27260156 | BXPC3 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | 0.18382259521587352 | [591] | [891,469,571,886] | 4 | hSpCas9 | negative selection | 5614214 | 157245917 | 157245940 | 5 | + | 27260156 | BXPC3 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.2271441654460608 | [574] | [407,523,433,719] | -5 | hSpCas9 | negative selection | 5614215 | 157245970 | 157245993 | 5 | + | 27260156 | A673 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.32354807482248005 | [591] | [616,566,510,582] | -7 | hSpCas9 | negative selection | 5735465 | 157245917 | 157245940 | 5 | + | 27260156 | A673 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.35078646982769324 | [574] | [524,530,501,608] | -7 | hSpCas9 | negative selection | 5735466 | 157245970 | 157245993 | 5 | + | 27260156 | A375 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.39369602793473313 | [591] | [466,588,653,414] | -5 | hSpCas9 | negative selection | 5856716 | 157245917 | 157245940 | 5 | + | 27260156 | A375 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.34591521472182263 | [574] | [502,620,653,365] | -5 | hSpCas9 | negative selection | 5856717 | 157245970 | 157245993 | 5 | + | 27260156 | COLO741 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | 0.06190229038346645 | [591] | [956,734,695] | 1 | hSpCas9 | negative selection | 5977967 | 157245917 | 157245940 | 5 | + | 27260156 | COLO741 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.09140479024177584 | [574] | [593,729,731] | -2 | hSpCas9 | negative selection | 5977968 | 157245970 | 157245993 | 5 | + | 27260156 | CAL120 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | 0.17429673708886928 | [591] | [861,686,946] | 2 | hSpCas9 | negative selection | 6099218 | 157245917 | 157245940 | 5 | + | 27260156 | CAL120 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.44908945195253624 | [574] | [379,675,494] | -6 | hSpCas9 | negative selection | 6099219 | 157245970 | 157245993 | 5 | + | 27260156 | CADOES1 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.38690256571310294 | [591] | [393,446,356,488] | -6 | hSpCas9 | negative selection | 6220469 | 157245917 | 157245940 | 5 | + | 27260156 | CADOES1 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.09964273466560519 | [574] | [547,560,525,355] | -2 | hSpCas9 | negative selection | 6220470 | 157245970 | 157245993 | 5 | + | 27260156 | EWS502 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | 0.0616176050235257 | [591] | [526,648,621,845] | 1 | hSpCas9 | negative selection | 6341720 | 157245917 | 157245940 | 5 | + | 27260156 | EWS502 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.40815191016722735 | [574] | [440,393,450,559] | -6 | hSpCas9 | negative selection | 6341721 | 157245970 | 157245993 | 5 | + | 27260156 | EW8 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.5303292011074467 | [591] | [505,404,253,195] | -7 | hSpCas9 | negative selection | 6462971 | 157245917 | 157245940 | 5 | + | 27260156 | EW8 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.5604571836656185 | [574] | [348,329,284,307] | -7 | hSpCas9 | negative selection | 6462972 | 157245970 | 157245993 | 5 | + | 27260156 | CORL105 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.039193129807976124 | [591] | [594,737,776,599] | 0 | hSpCas9 | negative selection | 6584222 | 157245917 | 157245940 | 5 | + | 27260156 | CORL105 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.25899431472737594 | [574] | [577,531,593,551] | -5 | hSpCas9 | negative selection | 6584223 | 157245970 | 157245993 | 5 | + | 27260156 | HS294T | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.14600332366227717 | [591] | [188,173,182,298] | -2 | hSpCas9 | negative selection | 6705473 | 157245917 | 157245940 | 5 | + | 27260156 | HS294T | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.15897635827221485 | [574] | [116,169,372,133] | -2 | hSpCas9 | negative selection | 6705474 | 157245970 | 157245993 | 5 | + | 27260156 | HCC44 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.317431681733585 | [591] | [523,524,799,347] | -5 | hSpCas9 | negative selection | 6826724 | 157245917 | 157245940 | 5 | + | 27260156 | HCC44 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.5867305621797028 | [574] | [580,429,423,309] | -7 | hSpCas9 | negative selection | 6826725 | 157245970 | 157245993 | 5 | + | 27260156 | G402 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | 0.027904174994367092 | [591] | [864,522,672,880] | 0 | hSpCas9 | negative selection | 6947975 | 157245917 | 157245940 | 5 | + | 27260156 | G402 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.1946751977594949 | [574] | [814,579,827,270] | -2 | hSpCas9 | negative selection | 6947976 | 157245970 | 157245993 | 5 | + | 27260156 | L33 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | 0.02642411426707908 | [591] | [487,277,337,708] | 0 | hSpCas9 | negative selection | 7069226 | 157245917 | 157245940 | 5 | + | 27260156 | L33 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.287297992225683 | [574] | [465,227,246,468] | -6 | hSpCas9 | negative selection | 7069227 | 157245970 | 157245993 | 5 | + | 27260156 | K562 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.3492303652170144 | [591] | [368,622,454,229] | -4 | hSpCas9 | negative selection | 7190477 | 157245917 | 157245940 | 5 | + | 27260156 | K562 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.6633235283356635 | [574] | [367,393,201,329] | -7 | hSpCas9 | negative selection | 7190478 | 157245970 | 157245993 | 5 | + | 27260156 | HT29 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.20901600238131351 | [591] | [744,717,566,489] | -4 | hSpCas9 | negative selection | 7311728 | 157245917 | 157245940 | 5 | + | 27260156 | HT29 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.22971001252134823 | [574] | [520,580,764,515] | -4 | hSpCas9 | negative selection | 7311729 | 157245970 | 157245993 | 5 | + | 27260156 | MHHES1 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.25867592238788367 | [591] | [529,763,377,559] | -5 | hSpCas9 | negative selection | 7432979 | 157245917 | 157245940 | 5 | + | 27260156 | MHHES1 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.18495113084809015 | [574] | [579,601,691,429] | -3 | hSpCas9 | negative selection | 7432980 | 157245970 | 157245993 | 5 | + | 27260156 | MEWO | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.13781935779990204 | [591] | [495,427,584] | -3 | hSpCas9 | negative selection | 7554230 | 157245917 | 157245940 | 5 | + | 27260156 | MEWO | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.37255096427706463 | [574] | [373,501,361] | -7 | hSpCas9 | negative selection | 7554231 | 157245970 | 157245993 | 5 | + | 27260156 | LNCAPCLONEFGC | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.23140233547544087 | [591] | [354,591,416,449] | -4 | hSpCas9 | negative selection | 7675481 | 157245917 | 157245940 | 5 | + | 27260156 | LNCAPCLONEFGC | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.552441811242895 | [574] | [250,314,576,314] | -7 | hSpCas9 | negative selection | 7675482 | 157245970 | 157245993 | 5 | + | 27260156 | PANC0327 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.20958518205705978 | [591] | [337,495,448,520] | -3 | hSpCas9 | negative selection | 7796732 | 157245917 | 157245940 | 5 | + | 27260156 | PANC0327 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.3214387236976077 | [574] | [251,556,432,360] | -5 | hSpCas9 | negative selection | 7796733 | 157245970 | 157245993 | 5 | + | 27260156 | NCIH2009 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | 0.1617290511337971 | [591] | [1116,706,991] | 2 | hSpCas9 | negative selection | 7917983 | 157245917 | 157245940 | 5 | + | 27260156 | NCIH2009 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.17625681264682252 | [574] | [801,694,652] | -2 | hSpCas9 | negative selection | 7917984 | 157245970 | 157245993 | 5 | + | 27260156 | NCIH1373 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | 0.18682948375843977 | [591] | [910,761,644,189] | 1 | hSpCas9 | negative selection | 8039234 | 157245917 | 157245940 | 5 | + | 27260156 | NCIH1373 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.3289950336600069 | [574] | [673,609,337,115] | -3 | hSpCas9 | negative selection | 8039235 | 157245970 | 157245993 | 5 | + | 27260156 | PATU8902 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.927512229883195 | [591] | [522,486,213,579] | -7 | hSpCas9 | negative selection | 8160485 | 157245917 | 157245940 | 5 | + | 27260156 | PATU8902 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.43486867847307575 | [574] | [789,571,406,647] | -4 | hSpCas9 | negative selection | 8160486 | 157245970 | 157245993 | 5 | + | 27260156 | PANC1 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | 0.030758937432347533 | [591] | [313,592,558,607] | 0 | hSpCas9 | negative selection | 8281736 | 157245917 | 157245940 | 5 | + | 27260156 | PANC1 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.2558772177813671 | [574] | [376,453,381,438] | -4 | hSpCas9 | negative selection | 8281737 | 157245970 | 157245993 | 5 | + | 27260156 | PANC0813 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | 0.17495473735481326 | [591] | [680,909,666,865] | 3 | hSpCas9 | negative selection | 8402987 | 157245917 | 157245940 | 5 | + | 27260156 | PANC0813 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.3383640456249729 | [574] | [885,310,519,455] | -5 | hSpCas9 | negative selection | 8402988 | 157245970 | 157245993 | 5 | + | 27260156 | RDES | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.14706745164287835 | [591] | [556,540,724,644] | -2 | hSpCas9 | negative selection | 8524238 | 157245917 | 157245940 | 5 | + | 27260156 | RDES | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.3319911438069604 | [574] | [394,614,515,587] | -5 | hSpCas9 | negative selection | 8524239 | 157245970 | 157245993 | 5 | + | 27260156 | PC3 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.18219131958683984 | [591] | [425,477,772,478] | -4 | hSpCas9 | negative selection | 8645489 | 157245917 | 157245940 | 5 | + | 27260156 | PC3 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.33418296060626634 | [574] | [286,441,951,356] | -6 | hSpCas9 | negative selection | 8645490 | 157245970 | 157245993 | 5 | + | 27260156 | PATU8988T | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.49268522656298275 | [591] | [421,380,312,517] | -7 | hSpCas9 | negative selection | 8766740 | 157245917 | 157245940 | 5 | + | 27260156 | PATU8988T | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.38977870003198706 | [574] | [448,317,516,398] | -6 | hSpCas9 | negative selection | 8766741 | 157245970 | 157245993 | 5 | + | 27260156 | T47D | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.08051687309696931 | [591] | [727,657,526,698] | -2 | hSpCas9 | negative selection | 8887991 | 157245917 | 157245940 | 5 | + | 27260156 | T47D | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.3458394070453256 | [574] | [404,589,585,519] | -6 | hSpCas9 | negative selection | 8887992 | 157245970 | 157245993 | 5 | + | 27260156 | SU8686 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | 0.11506406694379201 | [591] | [514,686,727,613] | 2 | hSpCas9 | negative selection | 9009242 | 157245917 | 157245940 | 5 | + | 27260156 | SU8686 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.22012351650823123 | [574] | [370,563,459,575] | -4 | hSpCas9 | negative selection | 9009243 | 157245970 | 157245993 | 5 | + | 27260156 | SKES1 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.27206878527161565 | [591] | [412,570,472,492] | -5 | hSpCas9 | negative selection | 9130493 | 157245917 | 157245940 | 5 | + | 27260156 | SKES1 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.43289795661747665 | [574] | [508,441,458,311] | -7 | hSpCas9 | negative selection | 9130494 | 157245970 | 157245993 | 5 | + | 27260156 | TOV112D | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.1449271311905711 | [591] | [739,718,455,297] | -3 | hSpCas9 | negative selection | 9251744 | 157245917 | 157245940 | 5 | + | 27260156 | TOV112D | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.36153218594514513 | [574] | [515,412,511,350] | -6 | hSpCas9 | negative selection | 9251745 | 157245970 | 157245993 | 5 | + | 27260156 | TC71 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.44893387442557176 | [591] | [556,461,389,449] | -8 | hSpCas9 | negative selection | 9372995 | 157245917 | 157245940 | 5 | + | 27260156 | TC71 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.3535841565506931 | [574] | [450,416,567,491] | -7 | hSpCas9 | negative selection | 9372996 | 157245970 | 157245993 | 5 | + | 27260156 | TC32 | viability | ATAGCAGCAAGTCCGATGTGTGG | ITK | ENSG00000113263 | -0.1256082467053761 | [591] | [402,434,754,499] | -2 | hSpCas9 | negative selection | 9494246 | 157245917 | 157245940 | 5 | + | 27260156 | TC32 | viability | CACCAAATTCCCGGTGAAGTGGG | ITK | ENSG00000113263 | -0.12742132719163957 | [574] | [463,411,604,522] | -2 | hSpCas9 | negative selection | 9494247 | 157181084 | 157181107 | 5 | - | 27869803 | HPAFII | viability after 27 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.8803300778164476 | [157] | [129,171,NaN] | 7 | hSpCas9 | negative selection | 9590866 | 157241642 | 157241665 | 5 | - | 27869803 | HPAFII | viability after 27 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 0.7769429029548831 | [639] | [821,371,NaN] | 6 | hSpCas9 | negative selection | 9590867 | 157181084 | 157181107 | 5 | - | 27869803 | HPAFII | viability after 15 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.45084109128761907 | [157] | [220,238,NaN] | 5 | hSpCas9 | negative selection | 9673315 | 157241642 | 157241665 | 5 | - | 27869803 | HPAFII | viability after 15 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | -0.034062959635729584 | [639] | [783,601,NaN] | 0 | hSpCas9 | negative selection | 9673316 | 157181084 | 157181107 | 5 | - | 27869803 | ASPC1 | viability after 36 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.13206212169285336 | [335] | [201,117,83] | 1 | hSpCas9 | negative selection | 9755764 | 157241642 | 157241665 | 5 | - | 27869803 | ASPC1 | viability after 36 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 0.43639651938665347 | [1545] | [1176,460,622] | 4 | hSpCas9 | negative selection | 9755765 | 157181084 | 157181107 | 5 | - | 27869803 | PATU8988S | viability after 35 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | -0.055783935862334544 | [305] | [147,88,NaN] | 0 | hSpCas9 | negative selection | 9838213 | 157241642 | 157241665 | 5 | - | 27869803 | PATU8988S | viability after 35 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 0.6192290591183178 | [1225] | [740,775,NaN] | 6 | hSpCas9 | negative selection | 9838214 | 157181084 | 157181107 | 5 | - | 27869803 | PATU8988S | viability after 31 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | -0.0665800702598408 | [305] | [79,162,NaN] | 0 | hSpCas9 | negative selection | 9920662 | 157241642 | 157241665 | 5 | - | 27869803 | PATU8988S | viability after 31 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 0.6826308475146052 | [1225] | [642,964,NaN] | 7 | hSpCas9 | negative selection | 9920663 | 157181084 | 157181107 | 5 | - | 27869803 | HPAFII | viability after 35 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.8719938545902055 | [157] | [104,192,NaN] | 6 | hSpCas9 | negative selection | 10003111 | 157241642 | 157241665 | 5 | - | 27869803 | HPAFII | viability after 35 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 0.31495212556519325 | [639] | [490,303,NaN] | 2 | hSpCas9 | negative selection | 10003112 | 157181084 | 157181107 | 5 | - | 27869803 | HPAFII | viability after 31 days | ATCTTCAAAGTATGCCAGGCTGG | ITK | ENSG00000113263 | 0.6852038122779335 | [157] | [121,164,NaN] | 5 | hSpCas9 | negative selection | 10085560 | 157241642 | 157241665 | 5 | - | 27869803 | HPAFII | viability after 31 days | CGGAGTCGAGTCACCAGGCCTGG | ITK | ENSG00000113263 | 0.18230164577624852 | [639] | [419,393,NaN] | 1 | hSpCas9 | negative selection | 10085561 | 157245916 | 157245939 | 5 | + | 28162770 | P31FUJ | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | 0.35855806750492825 | [524] | [790] | 4 | hSpCas9 | negative selection | 10176415 | 157240154 | 157240177 | 5 | - | 28162770 | P31FUJ | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 0.3796102745917987 | [294] | [450] | 4 | hSpCas9 | negative selection | 10176416 | 157243727 | 157243750 | 5 | + | 28162770 | P31FUJ | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | -0.20915093634973325 | [120] | [122] | -2 | hSpCas9 | negative selection | 10176417 | 157244360 | 157244383 | 5 | + | 28162770 | P31FUJ | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | 0.01411253605613827 | [74] | [88] | 0 | hSpCas9 | negative selection | 10176418 | 157248896 | 157248919 | 5 | + | 28162770 | P31FUJ | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | -0.26137135661114963 | [203] | [199] | -2 | hSpCas9 | negative selection | 10176419 | 157244292 | 157244315 | 5 | + | 28162770 | P31FUJ | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | 0.9822106865564719 | [27] | [64] | 9 | hSpCas9 | negative selection | 10176420 | 157244433 | 157244456 | 5 | + | 28162770 | P31FUJ | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | -0.007735648779605253 | [153] | [179] | 0 | hSpCas9 | negative selection | 10176421 | 157245916 | 157245939 | 5 | + | 28162770 | TF1 | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | NaN | [NaN] | [637] | 1 | hSpCas9 | negative selection | 10345781 | 157240154 | 157240177 | 5 | - | 28162770 | TF1 | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | NaN | [NaN] | [357] | 1 | hSpCas9 | negative selection | 10345782 | 157243727 | 157243750 | 5 | + | 28162770 | TF1 | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | NaN | [NaN] | [119] | 1 | hSpCas9 | negative selection | 10345783 | 157244360 | 157244383 | 5 | + | 28162770 | TF1 | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | NaN | [NaN] | [60] | 1 | hSpCas9 | negative selection | 10345784 | 157248896 | 157248919 | 5 | + | 28162770 | TF1 | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | NaN | [NaN] | [155] | 1 | hSpCas9 | negative selection | 10345785 | 157244292 | 157244315 | 5 | + | 28162770 | TF1 | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | NaN | [NaN] | [28] | 1 | hSpCas9 | negative selection | 10345786 | 157244433 | 157244456 | 5 | + | 28162770 | TF1 | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | NaN | [NaN] | [174] | 1 | hSpCas9 | negative selection | 10345787 | 157245916 | 157245939 | 5 | + | 28162770 | SKM1 | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | 0.9427470526577386 | [107] | [366] | 8 | hSpCas9 | negative selection | 10515147 | 157240154 | 157240177 | 5 | - | 28162770 | SKM1 | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 0.24276855736823222 | [97] | [204] | 2 | hSpCas9 | negative selection | 10515148 | 157243727 | 157243750 | 5 | + | 28162770 | SKM1 | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | -0.575841110752608 | [42] | [50] | -4 | hSpCas9 | negative selection | 10515149 | 157244360 | 157244383 | 5 | + | 28162770 | SKM1 | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | 0.14628944225065643 | [22] | [44] | 1 | hSpCas9 | negative selection | 10515150 | 157248896 | 157248919 | 5 | + | 28162770 | SKM1 | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | -0.5559268378681608 | [78] | [94] | -4 | hSpCas9 | negative selection | 10515151 | 157244292 | 157244315 | 5 | + | 28162770 | SKM1 | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | 1.2077456453720468 | [11] | [48] | 9 | hSpCas9 | negative selection | 10515152 | 157244433 | 157244456 | 5 | + | 28162770 | SKM1 | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | 1.5958508168638925 | [31] | [170] | 9 | hSpCas9 | negative selection | 10515153 | 157245916 | 157245939 | 5 | + | 28162770 | SKM1 | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | 0.9427470526577386 | [107] | [366] | 8 | hSpCas9 | negative selection | 10684513 | 157240154 | 157240177 | 5 | - | 28162770 | SKM1 | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 0.24276855736823222 | [97] | [204] | 2 | hSpCas9 | negative selection | 10684514 | 157243727 | 157243750 | 5 | + | 28162770 | SKM1 | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | -0.575841110752608 | [42] | [50] | -4 | hSpCas9 | negative selection | 10684515 | 157244360 | 157244383 | 5 | + | 28162770 | SKM1 | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | 0.14628944225065643 | [22] | [44] | 1 | hSpCas9 | negative selection | 10684516 | 157248896 | 157248919 | 5 | + | 28162770 | SKM1 | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | -0.5559268378681608 | [78] | [94] | -4 | hSpCas9 | negative selection | 10684517 | 157244292 | 157244315 | 5 | + | 28162770 | SKM1 | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | 1.2077456453720468 | [11] | [48] | 9 | hSpCas9 | negative selection | 10684518 | 157244433 | 157244456 | 5 | + | 28162770 | SKM1 | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | 1.5958508168638925 | [31] | [170] | 9 | hSpCas9 | negative selection | 10684519 | 157245916 | 157245939 | 5 | + | 28162770 | PL21 | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | 0.6634969363404175 | [366] | [252] | 6 | hSpCas9 | negative selection | 10853879 | 157240154 | 157240177 | 5 | - | 28162770 | PL21 | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 0.41331350579638926 | [313] | [181] | 3 | hSpCas9 | negative selection | 10853880 | 157243727 | 157243750 | 5 | + | 28162770 | PL21 | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | -1.143814786728041 | [131] | [25] | -6 | hSpCas9 | negative selection | 10853881 | 157244360 | 157244383 | 5 | + | 28162770 | PL21 | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | -0.8197599429483851 | [72] | [17] | -5 | hSpCas9 | negative selection | 10853882 | 157248896 | 157248919 | 5 | + | 28162770 | PL21 | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | -0.09794173844367449 | [299] | [121] | 0 | hSpCas9 | negative selection | 10853883 | 157244292 | 157244315 | 5 | + | 28162770 | PL21 | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | -0.5912737636992622 | [44] | [12] | -4 | hSpCas9 | negative selection | 10853884 | 157244433 | 157244456 | 5 | + | 28162770 | PL21 | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | -0.32181308870603553 | [111] | [38] | -2 | hSpCas9 | negative selection | 10853885 | 157245916 | 157245939 | 5 | + | 28162770 | P31FUJ | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | 0.35855806750492825 | [524] | [790] | 4 | hSpCas9 | negative selection | 11023245 | 157240154 | 157240177 | 5 | - | 28162770 | P31FUJ | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 0.3796102745917987 | [294] | [450] | 4 | hSpCas9 | negative selection | 11023246 | 157243727 | 157243750 | 5 | + | 28162770 | P31FUJ | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | -0.20915093634973325 | [120] | [122] | -2 | hSpCas9 | negative selection | 11023247 | 157244360 | 157244383 | 5 | + | 28162770 | P31FUJ | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | 0.01411253605613827 | [74] | [88] | 0 | hSpCas9 | negative selection | 11023248 | 157248896 | 157248919 | 5 | + | 28162770 | P31FUJ | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | -0.26137135661114963 | [203] | [199] | -2 | hSpCas9 | negative selection | 11023249 | 157244292 | 157244315 | 5 | + | 28162770 | P31FUJ | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | 0.9822106865564719 | [27] | [64] | 9 | hSpCas9 | negative selection | 11023250 | 157244433 | 157244456 | 5 | + | 28162770 | P31FUJ | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | -0.007735648779605253 | [153] | [179] | 0 | hSpCas9 | negative selection | 11023251 | 157245916 | 157245939 | 5 | + | 28162770 | OCIAML5 | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | 0.3162704336751234 | [302] | [680] | 2 | hSpCas9 | negative selection | 11192611 | 157240154 | 157240177 | 5 | - | 28162770 | OCIAML5 | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 0.7792888353416103 | [152] | [473] | 6 | hSpCas9 | negative selection | 11192612 | 157243727 | 157243750 | 5 | + | 28162770 | OCIAML5 | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | -0.7976187868416205 | [129] | [134] | -5 | hSpCas9 | negative selection | 11192613 | 157244360 | 157244383 | 5 | + | 28162770 | OCIAML5 | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | -0.2945848065649479 | [52] | [77] | -2 | hSpCas9 | negative selection | 11192614 | 157248896 | 157248919 | 5 | + | 28162770 | OCIAML5 | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | 0.5345672134111807 | [108] | [284] | 4 | hSpCas9 | negative selection | 11192615 | 157244292 | 157244315 | 5 | + | 28162770 | OCIAML5 | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | 0.342949411541146 | [37] | [86] | 3 | hSpCas9 | negative selection | 11192616 | 157244433 | 157244456 | 5 | + | 28162770 | OCIAML5 | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | -0.3348486767786749 | [108] | [155] | -2 | hSpCas9 | negative selection | 11192617 | 157245916 | 157245939 | 5 | + | 28162770 | EOL1 | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | -0.333120124513444 | [482] | [201] | -3 | hSpCas9 | negative selection | 11361977 | 157240154 | 157240177 | 5 | - | 28162770 | EOL1 | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 0.9269909474988635 | [589] | [590] | 7 | hSpCas9 | negative selection | 11361978 | 157243727 | 157243750 | 5 | + | 28162770 | EOL1 | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | 2.2622719553647657 | [217] | [550] | 9 | hSpCas9 | negative selection | 11361979 | 157244360 | 157244383 | 5 | + | 28162770 | EOL1 | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | -0.21517699209607866 | [129] | [58] | -2 | hSpCas9 | negative selection | 11361980 | 157248896 | 157248919 | 5 | + | 28162770 | EOL1 | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | -0.3416469751565874 | [456] | [189] | -3 | hSpCas9 | negative selection | 11361981 | 157244292 | 157244315 | 5 | + | 28162770 | EOL1 | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | 0.07655086501558461 | [26] | [14] | 0 | hSpCas9 | negative selection | 11361982 | 157244433 | 157244456 | 5 | + | 28162770 | EOL1 | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | 1.5338748206908905 | [136] | [208] | 9 | hSpCas9 | negative selection | 11361983 | 157245916 | 157245939 | 5 | + | 28162770 | MOLM13 | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | 0.7898174764319412 | [487] | [609] | 6 | hSpCas9 | negative selection | 11531343 | 157240154 | 157240177 | 5 | - | 28162770 | MOLM13 | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 0.9492066141119401 | [451] | [630] | 7 | hSpCas9 | negative selection | 11531344 | 157243727 | 157243750 | 5 | + | 28162770 | MOLM13 | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | 0.637259606959717 | [288] | [324] | 5 | hSpCas9 | negative selection | 11531345 | 157244360 | 157244383 | 5 | + | 28162770 | MOLM13 | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | 1.436995373598795 | [117] | [230] | 9 | hSpCas9 | negative selection | 11531346 | 157248896 | 157248919 | 5 | + | 28162770 | MOLM13 | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | -0.5467573944198225 | [395] | [195] | -3 | hSpCas9 | negative selection | 11531347 | 157244292 | 157244315 | 5 | + | 28162770 | MOLM13 | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | 0.8193617520459564 | [28] | [36] | 6 | hSpCas9 | negative selection | 11531348 | 157244433 | 157244456 | 5 | + | 28162770 | MOLM13 | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | 0.565405887458841 | [142] | [152] | 4 | hSpCas9 | negative selection | 11531349 | 157245916 | 157245939 | 5 | + | 28162770 | HEL | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | 0.7562871282493161 | [402] | [435] | 6 | hSpCas9 | negative selection | 11700709 | 157240154 | 157240177 | 5 | - | 28162770 | HEL | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 1.3898068297045265 | [369] | [620] | 9 | hSpCas9 | negative selection | 11700710 | 157243727 | 157243750 | 5 | + | 28162770 | HEL | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | 0.5421348910619513 | [192] | [179] | 4 | hSpCas9 | negative selection | 11700711 | 157244360 | 157244383 | 5 | + | 28162770 | HEL | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | 0.2683433172188592 | [104] | [80] | 2 | hSpCas9 | negative selection | 11700712 | 157248896 | 157248919 | 5 | + | 28162770 | HEL | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | -0.8157753334798601 | [392] | [142] | -5 | hSpCas9 | negative selection | 11700713 | 157244292 | 157244315 | 5 | + | 28162770 | HEL | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | -0.6791892628870055 | [59] | [23] | -4 | hSpCas9 | negative selection | 11700714 | 157244433 | 157244456 | 5 | + | 28162770 | HEL | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | 0.501077682776766 | [138] | [125] | 4 | hSpCas9 | negative selection | 11700715 | 157245916 | 157245939 | 5 | + | 28162770 | MV411 | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | -0.06677557897658137 | [372] | [299] | 0 | hSpCas9 | negative selection | 11870075 | 157240154 | 157240177 | 5 | - | 28162770 | MV411 | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 0.9040610366313779 | [287] | [453] | 7 | hSpCas9 | negative selection | 11870076 | 157243727 | 157243750 | 5 | + | 28162770 | MV411 | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | 0.22995012405393428 | [165] | [163] | 2 | hSpCas9 | negative selection | 11870077 | 157244360 | 157244383 | 5 | + | 28162770 | MV411 | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | 0.46392937067953904 | [104] | [121] | 4 | hSpCas9 | negative selection | 11870078 | 157248896 | 157248919 | 5 | + | 28162770 | MV411 | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | -0.4537179674429037 | [251] | [154] | -3 | hSpCas9 | negative selection | 11870079 | 157244292 | 157244315 | 5 | + | 28162770 | MV411 | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | 1.759336589314208 | [26] | [76] | 9 | hSpCas9 | negative selection | 11870080 | 157244433 | 157244456 | 5 | + | 28162770 | MV411 | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | 0.8886441621435507 | [108] | [169] | 7 | hSpCas9 | negative selection | 11870081 | 157245916 | 157245939 | 5 | + | 28162770 | MONOMAC1 | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | 0.3427736172692274 | [237] | [345] | 3 | hSpCas9 | negative selection | 12039441 | 157240154 | 157240177 | 5 | - | 28162770 | MONOMAC1 | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 0.741562608276303 | [203] | [390] | 7 | hSpCas9 | negative selection | 12039442 | 157243727 | 157243750 | 5 | + | 28162770 | MONOMAC1 | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | -0.058060433910743336 | [88] | [97] | 0 | hSpCas9 | negative selection | 12039443 | 157244360 | 157244383 | 5 | + | 28162770 | MONOMAC1 | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | -0.3940736941191074 | [46] | [40] | -3 | hSpCas9 | negative selection | 12039444 | 157248896 | 157248919 | 5 | + | 28162770 | MONOMAC1 | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | -0.3146884357138268 | [165] | [152] | -3 | hSpCas9 | negative selection | 12039445 | 157244292 | 157244315 | 5 | + | 28162770 | MONOMAC1 | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | -0.4111616524124013 | [28] | [24] | -4 | hSpCas9 | negative selection | 12039446 | 157244433 | 157244456 | 5 | + | 28162770 | MONOMAC1 | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | 0.7571594633273215 | [63] | [123] | 7 | hSpCas9 | negative selection | 12039447 | 157245916 | 157245939 | 5 | + | 28162770 | OCIAML2 | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | 0.12727173118649304 | [73] | [447] | 1 | hSpCas9 | negative selection | 12208807 | 157240154 | 157240177 | 5 | - | 28162770 | OCIAML2 | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 1.50720852483368 | [40] | [645] | 9 | hSpCas9 | negative selection | 12208808 | 157243727 | 157243750 | 5 | + | 28162770 | OCIAML2 | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | -0.7735569581994676 | [32] | [106] | -5 | hSpCas9 | negative selection | 12208809 | 157244360 | 157244383 | 5 | + | 28162770 | OCIAML2 | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | 0.1314061888379363 | [13] | [84] | 1 | hSpCas9 | negative selection | 12208810 | 157248896 | 157248919 | 5 | + | 28162770 | OCIAML2 | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | -0.15426125569669957 | [51] | [258] | -1 | hSpCas9 | negative selection | 12208811 | 157244292 | 157244315 | 5 | + | 28162770 | OCIAML2 | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | 0.9888017933951361 | [4] | [54] | 8 | hSpCas9 | negative selection | 12208812 | 157244433 | 157244456 | 5 | + | 28162770 | OCIAML2 | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | -1.1335948379645902 | [18] | [47] | -6 | hSpCas9 | negative selection | 12208813 | 157245916 | 157245939 | 5 | + | 28162770 | OCIAML3 | viability | GCACCAAATTCCCGGTGAAGTGG | ITK | ENSG00000113263 | 0.1598317724064391 | [101] | [343] | 1 | hSpCas9 | negative selection | 12378173 | 157240154 | 157240177 | 5 | - | 28162770 | OCIAML3 | viability | ATAGTTGATGAGAAGAGGGATGG | ITK | ENSG00000113263 | 0.4059923596758367 | [80] | [323] | 4 | hSpCas9 | negative selection | 12378174 | 157243727 | 157243750 | 5 | + | 28162770 | OCIAML3 | viability | GCTATCAAAACCATTCGGGAAGG | ITK | ENSG00000113263 | 0.2616024503406619 | [41] | [151] | 2 | hSpCas9 | negative selection | 12378175 | 157244360 | 157244383 | 5 | + | 28162770 | OCIAML3 | viability | CAGATTATCTACGCACCCAGCGG | ITK | ENSG00000113263 | -0.009045139603007124 | [15] | [47] | 0 | hSpCas9 | negative selection | 12378176 | 157248896 | 157248919 | 5 | + | 28162770 | OCIAML3 | viability | AAACCGAAGCAACTCAGAGGTGG | ITK | ENSG00000113263 | 1.2452720491296776 | [82] | [593] | 8 | hSpCas9 | negative selection | 12378177 | 157244292 | 157244315 | 5 | + | 28162770 | OCIAML3 | viability | GTATGGGGTGTGCCTGGAGCAGG | ITK | ENSG00000113263 | -0.5940076403241632 | [16] | [33] | -4 | hSpCas9 | negative selection | 12378178 | 157244433 | 157244456 | 5 | + | 28162770 | OCIAML3 | viability | GGGCATGGCCTACCTGGAAGAGG | ITK | ENSG00000113263 | 0.47416386231741625 | [30] | [129] | 4 | hSpCas9 | negative selection | 12378179 |