| 27219054 | 27219077 | 16 | - | 26472758 | Jiyoye | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -0.8407521319377123 | [94] | [39] | -5 | hSpCas9 | negative selection | 82163 | 27210185 | 27210208 | 16 | - | 26472758 | Jiyoye | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -0.05225623713142405 | [142] | [103] | 0 | hSpCas9 | negative selection | 82164 | 27210237 | 27210260 | 16 | + | 26472758 | Jiyoye | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -6.002215554631828 | [84] | [0] | -9 | hSpCas9 | negative selection | 82165 | 27210309 | 27210332 | 16 | + | 26472758 | Jiyoye | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | 5.53645839845084 | [0] | [34] | 9 | hSpCas9 | negative selection | 82166 | 27210534 | 27210557 | 16 | - | 26472758 | Jiyoye | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -0.7896253259278336 | [148] | [64] | -5 | hSpCas9 | negative selection | 82167 | 27219054 | 27219077 | 16 | - | 26472758 | KBM7 | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -2.344338865815813 | [377,190] | [23,26] | -9 | hSpCas9 | negative selection | 273281 | 27210185 | 27210208 | 16 | - | 26472758 | KBM7 | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -0.6641373668245587 | [902,802] | [227,274] | -5 | hSpCas9 | negative selection | 273282 | 27210237 | 27210260 | 16 | + | 26472758 | KBM7 | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -2.964361138274949 | [292,179] | [23,4] | -9 | hSpCas9 | negative selection | 273283 | 27210309 | 27210332 | 16 | + | 26472758 | KBM7 | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | -1.126061344187807 | [411,221] | [65,66] | -7 | hSpCas9 | negative selection | 273284 | 27210534 | 27210557 | 16 | - | 26472758 | KBM7 | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | 0.037174390201519476 | [504,419] | [181,257] | 0 | hSpCas9 | negative selection | 273285 | 27219054 | 27219077 | 16 | - | 26472758 | Raji | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -0.25301870732839854 | [189] | [36] | -2 | hSpCas9 | negative selection | 464399 | 27210185 | 27210208 | 16 | - | 26472758 | Raji | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | 0.2877502835375588 | [412] | [116] | 2 | hSpCas9 | negative selection | 464400 | 27210237 | 27210260 | 16 | + | 26472758 | Raji | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -1.1694566699852245 | [125] | [12] | -7 | hSpCas9 | negative selection | 464401 | 27210309 | 27210332 | 16 | + | 26472758 | Raji | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | 0.3151884204870012 | [141] | [40] | 3 | hSpCas9 | negative selection | 464402 | 27210534 | 27210557 | 16 | - | 26472758 | Raji | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -0.8048405045379597 | [270] | [35] | -6 | hSpCas9 | negative selection | 464403 | 27219054 | 27219077 | 16 | - | 26472758 | K562 | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -1.6989977439671855 | [199] | [51] | -7 | hSpCas9 | negative selection | 655517 | 27210185 | 27210208 | 16 | - | 26472758 | K562 | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -1.1616771289096741 | [696] | [262] | -6 | hSpCas9 | negative selection | 655518 | 27210237 | 27210260 | 16 | + | 26472758 | K562 | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -6.247434368663228 | [179] | [1] | -9 | hSpCas9 | negative selection | 655519 | 27210309 | 27210332 | 16 | + | 26472758 | K562 | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | -0.675854079862819 | [175] | [92] | -4 | hSpCas9 | negative selection | 655520 | 27210534 | 27210557 | 16 | - | 26472758 | K562 | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -1.460676351212737 | [387] | [118] | -6 | hSpCas9 | negative selection | 655521 | 27210353 | 27210376 | 16 | + | 26627737 | DLD1 | viability | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -1.6590230351263031 | [487] | [23,119,9] | -8 | hSpCas9 | negative selection | 793356 | 27215974 | 27215997 | 16 | - | 26627737 | DLD1 | viability | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -1.9665962710486957 | [238] | [26,10,18] | -8 | hSpCas9 | negative selection | 793357 | 27220467 | 27220490 | 16 | + | 26627737 | DLD1 | viability | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | -0.12655817150474874 | [328] | [102,77,99] | -1 | hSpCas9 | negative selection | 793358 | 27220652 | 27220675 | 16 | - | 26627737 | DLD1 | viability | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | -0.8435568906161899 | [311] | [94,39,30] | -7 | hSpCas9 | negative selection | 793359 | 27210353 | 27210376 | 16 | + | 26627737 | GBM cells | viability after 5 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | 0.10278620825133568 | [223] | [116,140] | 1 | hSpCas9 | negative selection | 875671 | 27215974 | 27215997 | 16 | - | 26627737 | GBM cells | viability after 5 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -0.1010861251143143 | [222] | [106,115] | -1 | hSpCas9 | negative selection | 875672 | 27220467 | 27220490 | 16 | + | 26627737 | GBM cells | viability after 5 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 0.20376845641410657 | [169] | [98,110] | 3 | hSpCas9 | negative selection | 875673 | 27220652 | 27220675 | 16 | - | 26627737 | GBM cells | viability after 5 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | 0.259661218663576 | [175] | [105,119] | 4 | hSpCas9 | negative selection | 875674 | 27210353 | 27210376 | 16 | + | 26627737 | GBM cells | viability after 13 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -0.37767676854624443 | [223] | [76,106] | -4 | hSpCas9 | negative selection | 957986 | 27215974 | 27215997 | 16 | - | 26627737 | GBM cells | viability after 13 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | 0.33338164695148825 | [222] | [152,151] | 4 | hSpCas9 | negative selection | 957987 | 27220467 | 27220490 | 16 | + | 26627737 | GBM cells | viability after 13 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 0.08493023609998868 | [169] | [104,91] | 1 | hSpCas9 | negative selection | 957988 | 27220652 | 27220675 | 16 | - | 26627737 | GBM cells | viability after 13 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | 0.3107879817404139 | [175] | [118,117] | 4 | hSpCas9 | negative selection | 957989 | 27210353 | 27210376 | 16 | + | 26627737 | GBM cells | viability after 21 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -1.2759104381402089 | [223] | [55,44] | -8 | hSpCas9 | negative selection | 1040301 | 27215974 | 27215997 | 16 | - | 26627737 | GBM cells | viability after 21 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -0.18987571118262336 | [222] | [112,99] | -2 | hSpCas9 | negative selection | 1040302 | 27220467 | 27220490 | 16 | + | 26627737 | GBM cells | viability after 21 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 0.8787238095057931 | [169] | [173,165] | 8 | hSpCas9 | negative selection | 1040303 | 27220652 | 27220675 | 16 | - | 26627737 | GBM cells | viability after 21 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | 0.0888199214270759 | [175] | [108,94] | 0 | hSpCas9 | negative selection | 1040304 | 27210353 | 27210376 | 16 | + | 26627737 | RPE1 | viability after 9 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | 1.059281779519721 | [392] | [203,323] | 6 | hSpCas9 | negative selection | 1122616 | 27215974 | 27215997 | 16 | - | 26627737 | RPE1 | viability after 9 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | 1.7570022385618427 | [293] | [204,447] | 8 | hSpCas9 | negative selection | 1122617 | 27220467 | 27220490 | 16 | + | 26627737 | RPE1 | viability after 9 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | -0.3476756405211773 | [713] | [193,151] | -2 | hSpCas9 | negative selection | 1122618 | 27220652 | 27220675 | 16 | - | 26627737 | RPE1 | viability after 9 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | -0.1025371086168676 | [578] | [146,196] | 0 | hSpCas9 | negative selection | 1122619 | 27210353 | 27210376 | 16 | + | 26627737 | RPE1 | viability after 12 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | 0.9929525186117574 | [392] | [248,168] | 6 | hSpCas9 | negative selection | 1204931 | 27215974 | 27215997 | 16 | - | 26627737 | RPE1 | viability after 12 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | 1.0781674027740462 | [293] | [124,210] | 6 | hSpCas9 | negative selection | 1204932 | 27220467 | 27220490 | 16 | + | 26627737 | RPE1 | viability after 12 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | -0.6228394496366395 | [713] | [143,103] | -4 | hSpCas9 | negative selection | 1204933 | 27220652 | 27220675 | 16 | - | 26627737 | RPE1 | viability after 12 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | -0.34114137583328175 | [578] | [98,147] | -2 | hSpCas9 | negative selection | 1204934 | 27210353 | 27210376 | 16 | + | 26627737 | RPE1 | viability after 15 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | 1.0737420399152846 | [392] | [261,206] | 6 | hSpCas9 | negative selection | 1287246 | 27215974 | 27215997 | 16 | - | 26627737 | RPE1 | viability after 15 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | 0.9158862434969779 | [293] | [189,124] | 5 | hSpCas9 | negative selection | 1287247 | 27220467 | 27220490 | 16 | + | 26627737 | RPE1 | viability after 15 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | -0.9592874457515045 | [713] | [166,42] | -6 | hSpCas9 | negative selection | 1287248 | 27220652 | 27220675 | 16 | - | 26627737 | RPE1 | viability after 15 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | -1.4078056762421367 | [578] | [76,46] | -7 | hSpCas9 | negative selection | 1287249 | 27210353 | 27210376 | 16 | + | 26627737 | RPE1 | viability after 18 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -0.5143750999338578 | [392] | [66,81] | -3 | hSpCas9 | negative selection | 1369561 | 27215974 | 27215997 | 16 | - | 26627737 | RPE1 | viability after 18 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | 1.0026638414035827 | [293] | [201,112] | 6 | hSpCas9 | negative selection | 1369562 | 27220467 | 27220490 | 16 | + | 26627737 | RPE1 | viability after 18 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | -1.5475838409079143 | [713] | [77,52] | -7 | hSpCas9 | negative selection | 1369563 | 27220652 | 27220675 | 16 | - | 26627737 | RPE1 | viability after 18 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | -0.9956150415172019 | [578] | [88,66] | -6 | hSpCas9 | negative selection | 1369564 | 27210353 | 27210376 | 16 | + | 26627737 | HeLa | viability after 8 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -1.3765473123447678 | [628] | [96,46,165] | -8 | hSpCas9 | negative selection | 1451876 | 27215974 | 27215997 | 16 | - | 26627737 | HeLa | viability after 8 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | 0.42140668229411443 | [237] | [202,173,58] | 4 | hSpCas9 | negative selection | 1451877 | 27220467 | 27220490 | 16 | + | 26627737 | HeLa | viability after 8 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 1.8475294475704696 | [163] | [191,348,217] | 9 | hSpCas9 | negative selection | 1451878 | 27220652 | 27220675 | 16 | - | 26627737 | HeLa | viability after 8 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | 0.5673329668944987 | [294] | [310,166,123] | 5 | hSpCas9 | negative selection | 1451879 | 27210353 | 27210376 | 16 | + | 26627737 | HeLa | viability after 12 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -1.0097032822943746 | [628] | [172,143,69] | -7 | hSpCas9 | negative selection | 1534191 | 27215974 | 27215997 | 16 | - | 26627737 | HeLa | viability after 12 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | 0.08027471089126603 | [237] | [172,46,99] | 0 | hSpCas9 | negative selection | 1534192 | 27220467 | 27220490 | 16 | + | 26627737 | HeLa | viability after 12 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 0.45613741315676515 | [163] | [53,109,111] | 4 | hSpCas9 | negative selection | 1534193 | 27220652 | 27220675 | 16 | - | 26627737 | HeLa | viability after 12 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | 0.21824826155310653 | [294] | [63,190,162] | 2 | hSpCas9 | negative selection | 1534194 | 27210353 | 27210376 | 16 | + | 26627737 | HeLa | viability after 15 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -1.8244870760176806 | [628] | [61,70,84] | -9 | hSpCas9 | negative selection | 1616506 | 27215974 | 27215997 | 16 | - | 26627737 | HeLa | viability after 15 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | 0.0432314971799721 | [237] | [146,62,87] | 0 | hSpCas9 | negative selection | 1616507 | 27220467 | 27220490 | 16 | + | 26627737 | HeLa | viability after 15 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 0.9149693266860518 | [163] | [232,56,82] | 7 | hSpCas9 | negative selection | 1616508 | 27220652 | 27220675 | 16 | - | 26627737 | HeLa | viability after 15 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | 0.42288695288684186 | [294] | [183,109,190] | 3 | hSpCas9 | negative selection | 1616509 | 27210353 | 27210376 | 16 | + | 26627737 | HeLa | viability after 18 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -1.8044364347286357 | [628] | [44,56,84] | -9 | hSpCas9 | negative selection | 1698821 | 27215974 | 27215997 | 16 | - | 26627737 | HeLa | viability after 18 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | 0.027059514929489326 | [237] | [94,53,87] | 0 | hSpCas9 | negative selection | 1698822 | 27220467 | 27220490 | 16 | + | 26627737 | HeLa | viability after 18 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 0.9528034022780081 | [163] | [162,46,82] | 7 | hSpCas9 | negative selection | 1698823 | 27220652 | 27220675 | 16 | - | 26627737 | HeLa | viability after 18 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | 0.3934544012064643 | [294] | [117,89,190] | 3 | hSpCas9 | negative selection | 1698824 | 27210353 | 27210376 | 16 | + | 26627737 | HCT116 | viability after 6 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -0.9449920846774051 | [847] | [56,75] | -5 | hSpCas9 | negative selection | 1781136 | 27215974 | 27215997 | 16 | - | 26627737 | HCT116 | viability after 6 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -1.6698048151652114 | [589] | [52,15] | -7 | hSpCas9 | negative selection | 1781137 | 27220467 | 27220490 | 16 | + | 26627737 | HCT116 | viability after 6 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 1.6287572081688995 | [560] | [400,201] | 8 | hSpCas9 | negative selection | 1781138 | 27220652 | 27220675 | 16 | - | 26627737 | HCT116 | viability after 6 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | 1.2306803031956808 | [699] | [216,280] | 6 | hSpCas9 | negative selection | 1781139 | 27210353 | 27210376 | 16 | + | 26627737 | HCT116 | viability after 8 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | 0.25646909411784624 | [136] | [62,112,93] | 3 | hSpCas9 | negative selection | 1863451 | 27215974 | 27215997 | 16 | - | 26627737 | HCT116 | viability after 8 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -0.13273929804541676 | [268] | [134,86,182] | -1 | hSpCas9 | negative selection | 1863452 | 27220467 | 27220490 | 16 | + | 26627737 | HCT116 | viability after 8 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 0.29809403580610994 | [157] | [92,47,178] | 3 | hSpCas9 | negative selection | 1863453 | 27220652 | 27220675 | 16 | - | 26627737 | HCT116 | viability after 8 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | -0.3895003905657289 | [314] | [124,190,81] | -4 | hSpCas9 | negative selection | 1863454 | 27210353 | 27210376 | 16 | + | 26627737 | HCT116 | viability after 9 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -1.8635030012481992 | [847] | [102,29] | -8 | hSpCas9 | negative selection | 1945766 | 27215974 | 27215997 | 16 | - | 26627737 | HCT116 | viability after 9 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -1.674037021397952 | [589] | [21,70] | -8 | hSpCas9 | negative selection | 1945767 | 27220467 | 27220490 | 16 | + | 26627737 | HCT116 | viability after 9 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 0.09359801323605003 | [560] | [251,86] | 0 | hSpCas9 | negative selection | 1945768 | 27220652 | 27220675 | 16 | - | 26627737 | HCT116 | viability after 9 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | -1.577009815101338 | [699] | [127,10] | -8 | hSpCas9 | negative selection | 1945769 | 27210353 | 27210376 | 16 | + | 26627737 | HCT116 | viability after 12 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -0.16753219750831616 | [136] | [78,63,47] | -2 | hSpCas9 | negative selection | 2028081 | 27215974 | 27215997 | 16 | - | 26627737 | HCT116 | viability after 12 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -0.5224794670465788 | [268] | [71,74,149] | -5 | hSpCas9 | negative selection | 2028082 | 27220467 | 27220490 | 16 | + | 26627737 | HCT116 | viability after 12 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | -0.25462984307746195 | [157] | [57,35,114] | -3 | hSpCas9 | negative selection | 2028083 | 27220652 | 27220675 | 16 | - | 26627737 | HCT116 | viability after 12 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | -0.3258434824931582 | [314] | [93,149,155] | -3 | hSpCas9 | negative selection | 2028084 | 27210353 | 27210376 | 16 | + | 26627737 | HCT116 | viability after 15 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | 0.06005886664590676 | [136] | [148,87,17] | 0 | hSpCas9 | negative selection | 2110396 | 27215974 | 27215997 | 16 | - | 26627737 | HCT116 | viability after 15 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -1.4711269523787538 | [268] | [23,57,80] | -8 | hSpCas9 | negative selection | 2110397 | 27220467 | 27220490 | 16 | + | 26627737 | HCT116 | viability after 15 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | -0.4947120460664757 | [157] | [120,7,70] | -5 | hSpCas9 | negative selection | 2110398 | 27220652 | 27220675 | 16 | - | 26627737 | HCT116 | viability after 15 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | -0.5188689244856484 | [314] | [104,129,140] | -5 | hSpCas9 | negative selection | 2110399 | 27210353 | 27210376 | 16 | + | 26627737 | HCT116 | viability after 18 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | 0.6605563579699074 | [136] | [29,195,80] | 5 | hSpCas9 | negative selection | 2192711 | 27215974 | 27215997 | 16 | - | 26627737 | HCT116 | viability after 18 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -2.166157872973365 | [268] | [25,20,40] | -9 | hSpCas9 | negative selection | 2192712 | 27220467 | 27220490 | 16 | + | 26627737 | HCT116 | viability after 18 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | -0.2696737569830968 | [157] | [71,51,66] | -2 | hSpCas9 | negative selection | 2192713 | 27220652 | 27220675 | 16 | - | 26627737 | HCT116 | viability after 18 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | -0.5326369617207034 | [314] | [78,105,131] | -5 | hSpCas9 | negative selection | 2192714 | 27210120 | 27210143 | 16 | - | 24336569 | HL60 | viability | AGTGGGTGTCTCCAGCCATCGGG | KDM8 | ENSG00000155666 | 1.1249867768385302 | [272] | [1259] | 8 | hSpCas9 | negative selection | 2272978 | 27210155 | 27210178 | 16 | - | 24336569 | HL60 | viability | TAAAGTGCCTTCTCTGGCCAGGG | KDM8 | ENSG00000155666 | 0.051238436857217406 | [300] | [659] | 0 | hSpCas9 | negative selection | 2272979 | 27210161 | 27210184 | 16 | - | 24336569 | HL60 | viability | CTCCCATAAAGTGCCTTCTCTGG | KDM8 | ENSG00000155666 | 1.1547615085827814 | [214] | [1012] | 8 | hSpCas9 | negative selection | 2272980 | 27210170 | 27210193 | 16 | + | 24336569 | HL60 | viability | GCACTTTATGGGAGGCCCTCAGG | KDM8 | ENSG00000155666 | -2.0517167572348445 | [287] | [146] | -9 | hSpCas9 | negative selection | 2272981 | 27210185 | 27210208 | 16 | - | 24336569 | HL60 | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -0.13287961012944532 | [456] | [881] | -1 | hSpCas9 | negative selection | 2272982 | 27210198 | 27210221 | 16 | - | 24336569 | HL60 | viability | GGTCTTCTTTACTGTGCGGCAGG | KDM8 | ENSG00000155666 | 0.7978544169486406 | [242] | [893] | 6 | hSpCas9 | negative selection | 2272983 | 27210214 | 27210237 | 16 | + | 24336569 | HL60 | viability | GAAGACCTGAAGTTGGACCTCGG | KDM8 | ENSG00000155666 | 0.39286392309066653 | [726] | [2019] | 3 | hSpCas9 | negative selection | 2272984 | 27210237 | 27210260 | 16 | + | 24336569 | HL60 | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -0.9773556972881579 | [587] | [631] | -7 | hSpCas9 | negative selection | 2272985 | 27210276 | 27210299 | 16 | + | 24336569 | HL60 | viability | AGCCACTGAGCTCTTCTACGAGG | KDM8 | ENSG00000155666 | 0.5900028578038012 | [560] | [1786] | 5 | hSpCas9 | negative selection | 2272986 | 27210281 | 27210304 | 16 | + | 24336569 | HL60 | viability | CTGAGCTCTTCTACGAGGGCAGG | KDM8 | ENSG00000155666 | 1.6694808399217929 | [189] | [1278] | 9 | hSpCas9 | negative selection | 2272987 | 27210120 | 27210143 | 16 | - | 24336569 | KBM7 | viability | AGTGGGTGTCTCCAGCCATCGGG | KDM8 | ENSG00000155666 | 1.4030128193493179 | [215] | [1557] | 9 | hSpCas9 | negative selection | 2340155 | 27210155 | 27210178 | 16 | - | 24336569 | KBM7 | viability | TAAAGTGCCTTCTCTGGCCAGGG | KDM8 | ENSG00000155666 | 0.6555142964152212 | [188] | [811] | 6 | hSpCas9 | negative selection | 2340156 | 27210161 | 27210184 | 16 | - | 24336569 | KBM7 | viability | CTCCCATAAAGTGCCTTCTCTGG | KDM8 | ENSG00000155666 | 1.561686699405969 | [193] | [1561] | 9 | hSpCas9 | negative selection | 2340157 | 27210170 | 27210193 | 16 | + | 24336569 | KBM7 | viability | GCACTTTATGGGAGGCCCTCAGG | KDM8 | ENSG00000155666 | 0.6296638023835781 | [99] | [421] | 6 | hSpCas9 | negative selection | 2340158 | 27210185 | 27210208 | 16 | - | 24336569 | KBM7 | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -0.457871951556716 | [421] | [837] | -4 | hSpCas9 | negative selection | 2340159 | 27210198 | 27210221 | 16 | - | 24336569 | KBM7 | viability | GGTCTTCTTTACTGTGCGGCAGG | KDM8 | ENSG00000155666 | 0.2903168684918145 | [154] | [516] | 2 | hSpCas9 | negative selection | 2340160 | 27210214 | 27210237 | 16 | + | 24336569 | KBM7 | viability | GAAGACCTGAAGTTGGACCTCGG | KDM8 | ENSG00000155666 | 0.19600603913717113 | [425] | [1330] | 1 | hSpCas9 | negative selection | 2340161 | 27210237 | 27210260 | 16 | + | 24336569 | KBM7 | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -5.3220483144650235 | [395] | [26] | -9 | hSpCas9 | negative selection | 2340162 | 27210276 | 27210299 | 16 | + | 24336569 | KBM7 | viability | AGCCACTGAGCTCTTCTACGAGG | KDM8 | ENSG00000155666 | -1.685270754268213 | [394] | [334] | -8 | hSpCas9 | negative selection | 2340163 | 27210281 | 27210304 | 16 | + | 24336569 | KBM7 | viability | CTGAGCTCTTCTACGAGGGCAGG | KDM8 | ENSG00000155666 | 1.452053844921347 | [92] | [693] | 9 | hSpCas9 | negative selection | 2340164 | 27203806 | 27203829 | 16 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | AATGCAATTTAGCTCGTCGCCGG | KDM8 | ENSG00000155666 | 1.84599653057974 | [128,456] | [14,469] | 6 | dCas9-VP64 | positive selection | 2402418 | 27203834 | 27203857 | 16 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | CTTTCCCTTTATCCTCCCGCAGG | KDM8 | ENSG00000155666 | -0.7463826380196636 | [619,25] | [69,9] | -4 | dCas9-VP64 | positive selection | 2402419 | 27203870 | 27203893 | 16 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GTATGCTCGTCTCTTGGCAGTGG | KDM8 | ENSG00000155666 | -1.2583204750554273 | [31,72] | [5,2] | -7 | dCas9-VP64 | positive selection | 2402420 | 27213243 | 27213266 | 16 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GTGTGTGTGTGTGTGTGTGTAAG | KDM8 | ENSG00000155666 | 4.847110262494055 | [32,12] | [264,23] | 9 | dCas9-VP64 | positive selection | 2428702 | 27211702 | 27211725 | 16 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GGAGTCTCACTCTGTCACCCCGG | KDM8 | ENSG00000155666 | 0.5662063265134789 | [296,266] | [152,24] | 2 | dCas9-VP64 | positive selection | 2439461 | 27207173 | 27207196 | 16 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | TGAGGTGGGTGGATCACTTGTGG | KDM8 | ENSG00000155666 | 0.9269503688862448 | [9,0] | [1,1] | 4 | dCas9-VP64 | positive selection | 2463155 | 27203806 | 27203829 | 16 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | AATGCAATTTAGCTCGTCGCCGG | KDM8 | ENSG00000155666 | 0.737963822950483 | [106,53] | [54,33] | 5 | dCas9-VP64 | positive selection | 2497673 | 27203834 | 27203857 | 16 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | CTTTCCCTTTATCCTCCCGCAGG | KDM8 | ENSG00000155666 | -0.2147151854989706 | [228,47] | [64,14] | -2 | dCas9-VP64 | positive selection | 2497674 | 27203870 | 27203893 | 16 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GTATGCTCGTCTCTTGGCAGTGG | KDM8 | ENSG00000155666 | 0.26343008818408303 | [79,144] | [24,60] | 2 | dCas9-VP64 | positive selection | 2497675 | 27213243 | 27213266 | 16 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GTGTGTGTGTGTGTGTGTGTAAG | KDM8 | ENSG00000155666 | 0.8889753160498469 | [90,141] | [86,53] | 6 | dCas9-VP64 | positive selection | 2523957 | 27211702 | 27211725 | 16 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GGAGTCTCACTCTGTCACCCCGG | KDM8 | ENSG00000155666 | -0.8868396810076964 | [300,188] | [54,31] | -8 | dCas9-VP64 | positive selection | 2534716 | 27207173 | 27207196 | 16 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | TGAGGTGGGTGGATCACTTGTGG | KDM8 | ENSG00000155666 | -0.7008385215102662 | [31,39] | [9,2] | -6 | dCas9-VP64 | positive selection | 2558410 | 27210479 | 27210502 | 16 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GCCCATGTCACAGACCCGCAGGG | KDM8 | ENSG00000155666 | -0.5443679622825007 | [3,3] | [2,1] | -7 | hSpCas9 | positive selection | 2997115 | 27210278 | 27210301 | 16 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GCCCTCGTAGAAGAGCTCAGTGG | KDM8 | ENSG00000155666 | -0.7903328574272637 | [1,1] | [0,0] | -8 | hSpCas9 | positive selection | 2997116 | 27210286 | 27210309 | 16 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GCTCTTCTACGAGGGCAGGAGGG | KDM8 | ENSG00000155666 | -1.484839397745137 | [4,4] | [0,0] | -9 | hSpCas9 | positive selection | 2997117 | 27210479 | 27210502 | 16 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GCCCATGTCACAGACCCGCAGGG | KDM8 | ENSG00000155666 | -0.7509197230326494 | [3,3] | [2,0] | -8 | hSpCas9 | positive selection | 3064973 | 27210278 | 27210301 | 16 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GCCCTCGTAGAAGAGCTCAGTGG | KDM8 | ENSG00000155666 | -0.9512991511632981 | [1,1] | [0,0] | -9 | hSpCas9 | positive selection | 3064974 | 27210286 | 27210309 | 16 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GCTCTTCTACGAGGGCAGGAGGG | KDM8 | ENSG00000155666 | -0.28707118405971077 | [4,4] | [1,2] | -4 | hSpCas9 | positive selection | 3064975 | 27210106 | 27210129 | | - | 24336571 | A375 | resistance to PLX after 7 days | GCCATCGGGCCACCACCAGCTGG | KDM8 | ENSG00000155666 | 0.5582435760474778 | [3,4] | [5,7] | 9 | hSpCas9 | positive selection | 3122753 | 27210347 | 27210370 | | - | 24336571 | A375 | resistance to PLX after 7 days | GCCCGTGTTGAGCTTCTCCCAGG | KDM8 | ENSG00000155666 | 0.2491216533050565 | [12,10] | [13,12] | 7 | hSpCas9 | positive selection | 3122754 | 27210106 | 27210129 | | - | 24336571 | A375 | resistance to PLX after 14 days | GCCATCGGGCCACCACCAGCTGG | KDM8 | ENSG00000155666 | 0.14154411973532066 | [4,4] | [1,2] | 1 | hSpCas9 | positive selection | 3180546 | 27210347 | 27210370 | | - | 24336571 | A375 | resistance to PLX after 14 days | GCCCGTGTTGAGCTTCTCCCAGG | KDM8 | ENSG00000155666 | -0.5946777703478043 | [12,5] | [2,1] | -7 | hSpCas9 | positive selection | 3180547 | 27210106 | 27210129 | | - | 24336571 | A375 | viability after 7 days | GCCATCGGGCCACCACCAGCTGG | KDM8 | ENSG00000155666 | 0.23789639784802397 | [3] | [3,4] | 3 | hSpCas9 | negative selection | 3238339 | 27210347 | 27210370 | | - | 24336571 | A375 | viability after 7 days | GCCCGTGTTGAGCTTCTCCCAGG | KDM8 | ENSG00000155666 | -1.1424758709048604 | [27] | [12,10] | -9 | hSpCas9 | negative selection | 3238340 | 27210106 | 27210129 | | - | 24336571 | A375 | viability after 14 days | GCCATCGGGCCACCACCAGCTGG | KDM8 | ENSG00000155666 | 0.3663545006928981 | [3] | [4,4] | 5 | hSpCas9 | negative selection | 3296132 | 27210347 | 27210370 | | - | 24336571 | A375 | viability after 14 days | GCCCGTGTTGAGCTTCTCCCAGG | KDM8 | ENSG00000155666 | -1.3491491133576043 | [27] | [12,5] | -9 | hSpCas9 | negative selection | 3296133 | 27210479 | 27210502 | 16 | - | 26780180 | HT29 | viability (Avana library 4 designs) | GCCCATGTCACAGACCCGCAGGG | KDM8 | ENSG00000155666 | 3.86866637582361 | [] | [] | 9 | hSpCas9 | negative selection | 3434531 | 27210278 | 27210301 | 16 | - | 26780180 | HT29 | viability (Avana library 4 designs) | GCCCTCGTAGAAGAGCTCAGTGG | KDM8 | ENSG00000155666 | 4.28705647442344 | [] | [] | 9 | hSpCas9 | negative selection | 3434532 | 27210285 | 27210308 | 16 | + | 26780180 | HT29 | viability (Avana library 4 designs) | GCTCTTCTACGAGGGCAGGAGGG | KDM8 | ENSG00000155666 | 4.2082108693724 | [] | [] | 9 | hSpCas9 | negative selection | 3434533 | 27210285 | 27210308 | 16 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCTCTTCTACGAGGGCAGGAGGG | KDM8 | ENSG00000155666 | -9.32397828453126 | [] | [] | -7 | hSpCas9 | negative selection | 3521676 | 27210278 | 27210301 | 16 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCCCTCGTAGAAGAGCTCAGTGG | KDM8 | ENSG00000155666 | -10.2915285662061 | [] | [] | -7 | hSpCas9 | negative selection | 3521677 | 27210479 | 27210502 | 16 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCCCATGTCACAGACCCGCAGGG | KDM8 | ENSG00000155666 | -4.15808192873878 | [] | [] | -5 | hSpCas9 | negative selection | 3521678 | 27210231 | 27210254 | 16 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TCCTCTCCACTTTCTCCCCGAGG | KDM8 | ENSG00000155666 | 1.73849134619589 | [] | [] | 2 | hSpCas9 | negative selection | 3521679 | 27210285 | 27210308 | 16 | + | 26780180 | A375 | viability (Avana lentiGuide) | GCTCTTCTACGAGGGCAGGAGGG | KDM8 | ENSG00000155666 | 14.0367462173274 | [] | [] | 7 | hSpCas9 | negative selection | 3630335 | 27210278 | 27210301 | 16 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCCCTCGTAGAAGAGCTCAGTGG | KDM8 | ENSG00000155666 | 8.87694644116807 | [] | [] | 6 | hSpCas9 | negative selection | 3630336 | 27210479 | 27210502 | 16 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCCCATGTCACAGACCCGCAGGG | KDM8 | ENSG00000155666 | 9.38128770881672 | [] | [] | 6 | hSpCas9 | negative selection | 3630337 | 27210231 | 27210254 | 16 | - | 26780180 | A375 | viability (Avana lentiGuide) | TCCTCTCCACTTTCTCCCCGAGG | KDM8 | ENSG00000155666 | 10.9954831432596 | [] | [] | 7 | hSpCas9 | negative selection | 3630338 | 27210285 | 27210308 | 16 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCTCTTCTACGAGGGCAGGAGGG | KDM8 | ENSG00000155666 | -0.07843065727857705 | [5] | [5,5] | -1 | hSpCas9 | positive selection | 3738994 | 27210278 | 27210301 | 16 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCCCTCGTAGAAGAGCTCAGTGG | KDM8 | ENSG00000155666 | -1.4396873871490519 | [4] | [0,0] | -9 | hSpCas9 | positive selection | 3738995 | 27210479 | 27210502 | 16 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCCCATGTCACAGACCCGCAGGG | KDM8 | ENSG00000155666 | 0.03795633149074374 | [5] | [6,3] | 0 | hSpCas9 | positive selection | 3738996 | 27210231 | 27210254 | 16 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TCCTCTCCACTTTCTCCCCGAGG | KDM8 | ENSG00000155666 | 0.10920857836210324 | [5] | [6,5] | 3 | hSpCas9 | positive selection | 3738997 | 27210285 | 27210308 | 16 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCTCTTCTACGAGGGCAGGAGGG | KDM8 | ENSG00000155666 | -0.9372144698531867 | [6] | [0,3] | -8 | hSpCas9 | positive selection | 3847601 | 27210278 | 27210301 | 16 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCCCTCGTAGAAGAGCTCAGTGG | KDM8 | ENSG00000155666 | -2.1804931528803073 | [4] | [0,0] | -9 | hSpCas9 | positive selection | 3847602 | 27210479 | 27210502 | 16 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCCCATGTCACAGACCCGCAGGG | KDM8 | ENSG00000155666 | -0.3306349568810781 | [5] | [3,3] | -4 | hSpCas9 | positive selection | 3847603 | 27210231 | 27210254 | 16 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TCCTCTCCACTTTCTCCCCGAGG | KDM8 | ENSG00000155666 | -0.0023156387935985845 | [8] | [6,6] | 0 | hSpCas9 | positive selection | 3847604 | 27215945 | 27215968 | 16 | - | 26780180 | A375 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | 1.52100860314644 | [] | [] | 8 | hSpCas9 | negative selection | 3953623 | 27215936 | 27215959 | 16 | + | 26780180 | A375 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | 1.0079211740527 | [] | [] | 5 | hSpCas9 | negative selection | 3953624 | 27215945 | 27215968 | 16 | - | 26780180 | HT29 | viability (GeCKOv2 library) | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | 1.70495602731991 | [] | [] | 8 | hSpCas9 | negative selection | 4061589 | 27215936 | 27215959 | 16 | + | 26780180 | HT29 | viability (GeCKOv2 library) | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | 1.24661746410341 | [] | [] | 6 | hSpCas9 | negative selection | 4061590 | 27210106 | 27210129 | 16 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | GCCATCGGGCCACCACCAGCTGG | KDM8 | ENSG00000155666 | 0.2204702509188407 | [2] | [3,0] | 5 | hSpCas9 | positive selection | 4146552 | 27210347 | 27210370 | 16 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | GCCCGTGTTGAGCTTCTCCCAGG | KDM8 | ENSG00000155666 | -0.6909259629798796 | [4] | [1,1] | -9 | hSpCas9 | positive selection | 4146553 | 27210106 | 27210129 | 16 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | GCCATCGGGCCACCACCAGCTGG | KDM8 | ENSG00000155666 | -0.12804451921805876 | [2] | [2,0,0,0] | -2 | hSpCas9 | positive selection | 4210574 | 27210347 | 27210370 | 16 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | GCCCGTGTTGAGCTTCTCCCAGG | KDM8 | ENSG00000155666 | 0.8901929728100227 | [4] | [2,4,0,3] | 6 | hSpCas9 | positive selection | 4210575 | 27215945 | 27215968 | 16 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.3864716272225676 | [3] | [2,0] | -7 | hSpCas9 | positive selection | 4278218 | 27215936 | 27215959 | 16 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.4448328123351899 | [1] | [1,0] | -7 | hSpCas9 | positive selection | 4278219 | 27210216 | 27210238 | 16 | + | 27760321 | OCIAML3 | viability | AGACCTGAAGTTGGACCTCGGG | KDM8 | ENSG00000155666 | 0.12966986999417773 | [573,480] | [393,521] | 1 | hSpCas9 | negative selection | 4411769 | 27210285 | 27210307 | 16 | + | 27760321 | OCIAML3 | viability | GCTCTTCTACGAGGGCAGGAGG | KDM8 | ENSG00000155666 | 0.15592029109743413 | [523,511] | [464,435] | 1 | hSpCas9 | negative selection | 4411770 | 27210354 | 27210376 | 16 | + | 27760321 | OCIAML3 | viability | GAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | 0.08591810883637463 | [602,455] | [438,431] | 1 | hSpCas9 | negative selection | 4411771 | 27210479 | 27210501 | 16 | + | 27760321 | OCIAML3 | viability | CCCTGCGGGTCTGTGACATGGG | KDM8 | ENSG00000155666 | -0.5997865618157342 | [544,568] | [251,336] | -5 | hSpCas9 | negative selection | 4411772 | 27210534 | 27210556 | 16 | - | 27760321 | OCIAML3 | viability | GATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -1.0361788969263697 | [242,178] | [100,51] | -7 | hSpCas9 | negative selection | 4411773 | 27210216 | 27210238 | 16 | + | 27760321 | OCIAML2 | viability | AGACCTGAAGTTGGACCTCGGG | KDM8 | ENSG00000155666 | 0.0978814353981835 | [573,480] | [409,513] | 1 | hSpCas9 | negative selection | 4495232 | 27210285 | 27210307 | 16 | + | 27760321 | OCIAML2 | viability | GCTCTTCTACGAGGGCAGGAGG | KDM8 | ENSG00000155666 | 0.01888940936002123 | [523,511] | [406,449] | 0 | hSpCas9 | negative selection | 4495233 | 27210354 | 27210376 | 16 | + | 27760321 | OCIAML2 | viability | GAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | 0.26932686050590865 | [602,455] | [417,635] | 3 | hSpCas9 | negative selection | 4495234 | 27210479 | 27210501 | 16 | + | 27760321 | OCIAML2 | viability | CCCTGCGGGTCTGTGACATGGG | KDM8 | ENSG00000155666 | -0.0030224309535720195 | [544,568] | [400,518] | 0 | hSpCas9 | negative selection | 4495235 | 27210534 | 27210556 | 16 | - | 27760321 | OCIAML2 | viability | GATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -0.2873762727971061 | [242,178] | [157,112] | -4 | hSpCas9 | negative selection | 4495236 | 27210216 | 27210238 | 16 | + | 27760321 | MV411 | viability | AGACCTGAAGTTGGACCTCGGG | KDM8 | ENSG00000155666 | -0.5213849297749709 | [573,480] | [195,309] | -4 | hSpCas9 | negative selection | 4578695 | 27210285 | 27210307 | 16 | + | 27760321 | MV411 | viability | GCTCTTCTACGAGGGCAGGAGG | KDM8 | ENSG00000155666 | 0.2443371414464943 | [523,511] | [474,301] | 1 | hSpCas9 | negative selection | 4578696 | 27210354 | 27210376 | 16 | + | 27760321 | MV411 | viability | GAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -1.3589331836297391 | [602,455] | [41,274] | -7 | hSpCas9 | negative selection | 4578697 | 27210479 | 27210501 | 16 | + | 27760321 | MV411 | viability | CCCTGCGGGTCTGTGACATGGG | KDM8 | ENSG00000155666 | -1.888455189629059 | [544,568] | [74,136] | -8 | hSpCas9 | negative selection | 4578698 | 27210534 | 27210556 | 16 | - | 27760321 | MV411 | viability | GATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -1.565868775029422 | [242,178] | [46,45] | -7 | hSpCas9 | negative selection | 4578699 | 27210216 | 27210238 | 16 | + | 27760321 | HL60 | viability | AGACCTGAAGTTGGACCTCGGG | KDM8 | ENSG00000155666 | -0.5260943575782979 | [573,480] | [249,348] | -5 | hSpCas9 | negative selection | 4662158 | 27210285 | 27210307 | 16 | + | 27760321 | HL60 | viability | GCTCTTCTACGAGGGCAGGAGG | KDM8 | ENSG00000155666 | 0.3586457650526764 | [523,511] | [620,461] | 4 | hSpCas9 | negative selection | 4662159 | 27210354 | 27210376 | 16 | + | 27760321 | HL60 | viability | GAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | 0.38281095276398297 | [602,455] | [406,720] | 5 | hSpCas9 | negative selection | 4662160 | 27210479 | 27210501 | 16 | + | 27760321 | HL60 | viability | CCCTGCGGGTCTGTGACATGGG | KDM8 | ENSG00000155666 | 0.30288713804832795 | [544,568] | [468,664] | 4 | hSpCas9 | negative selection | 4662161 | 27210534 | 27210556 | 16 | - | 27760321 | HL60 | viability | GATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -0.12446565249611874 | [242,178] | [128,185] | -1 | hSpCas9 | negative selection | 4662162 | 27210216 | 27210238 | 16 | + | 27760321 | HT1080 | viability | AGACCTGAAGTTGGACCTCGGG | KDM8 | ENSG00000155666 | -1.3433226324282994 | [480,375] | [9,129] | -5 | hSpCas9 | negative selection | 4745621 | 27210285 | 27210307 | 16 | + | 27760321 | HT1080 | viability | GCTCTTCTACGAGGGCAGGAGG | KDM8 | ENSG00000155666 | -1.862010635242203 | [511,399] | [59,38] | -6 | hSpCas9 | negative selection | 4745622 | 27210354 | 27210376 | 16 | + | 27760321 | HT1080 | viability | GAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -4.8256144345163 | [455,355] | [9,0] | -8 | hSpCas9 | negative selection | 4745623 | 27210479 | 27210501 | 16 | + | 27760321 | HT1080 | viability | CCCTGCGGGTCTGTGACATGGG | KDM8 | ENSG00000155666 | -4.257818528903292 | [568,443] | [0,20] | -8 | hSpCas9 | negative selection | 4745624 | 27210534 | 27210556 | 16 | - | 27760321 | HT1080 | viability | GATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -5.989785225073555 | [178,139] | [0,0] | -9 | hSpCas9 | negative selection | 4745625 | 27210216 | 27210238 | 16 | + | 27760321 | HT29 | viability after 7 days | AGACCTGAAGTTGGACCTCGGG | KDM8 | ENSG00000155666 | 0.35414717155951386 | [480,375] | [959,474,712] | 5 | hSpCas9 | negative selection | 4829084 | 27210285 | 27210307 | 16 | + | 27760321 | HT29 | viability after 7 days | GCTCTTCTACGAGGGCAGGAGG | KDM8 | ENSG00000155666 | 0.37337602216901716 | [511,399] | [1040,530,745] | 6 | hSpCas9 | negative selection | 4829085 | 27210354 | 27210376 | 16 | + | 27760321 | HT29 | viability after 7 days | GAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | 0.4280412540755425 | [455,355] | [823,778,525] | 6 | hSpCas9 | negative selection | 4829086 | 27210479 | 27210501 | 16 | + | 27760321 | HT29 | viability after 7 days | CCCTGCGGGTCTGTGACATGGG | KDM8 | ENSG00000155666 | 0.13882040099825504 | [568,443] | [846,812,514] | 2 | hSpCas9 | negative selection | 4829087 | 27210534 | 27210556 | 16 | - | 27760321 | HT29 | viability after 7 days | GATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -0.4945360462142878 | [178,139] | [124,207,101] | -6 | hSpCas9 | negative selection | 4829088 | 27210216 | 27210238 | 16 | + | 27760321 | HT29 | viability after 25 days | AGACCTGAAGTTGGACCTCGGG | KDM8 | ENSG00000155666 | -0.7316630464308531 | [480,375] | [224,426,229] | -6 | hSpCas9 | negative selection | 4912547 | 27210285 | 27210307 | 16 | + | 27760321 | HT29 | viability after 25 days | GCTCTTCTACGAGGGCAGGAGG | KDM8 | ENSG00000155666 | -2.403376322885712 | [511,399] | [151,32,107] | -8 | hSpCas9 | negative selection | 4912548 | 27210354 | 27210376 | 16 | + | 27760321 | HT29 | viability after 25 days | GAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -0.9455641756377853 | [455,355] | [262,173,288] | -6 | hSpCas9 | negative selection | 4912549 | 27210479 | 27210501 | 16 | + | 27760321 | HT29 | viability after 25 days | CCCTGCGGGTCTGTGACATGGG | KDM8 | ENSG00000155666 | -3.165626794962248 | [568,443] | [22,82,92] | -8 | hSpCas9 | negative selection | 4912550 | 27210534 | 27210556 | 16 | - | 27760321 | HT29 | viability after 25 days | GATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -2.6137193832533745 | [178,139] | [0,69,18] | -8 | hSpCas9 | negative selection | 4912551 | 27210216 | 27210238 | 16 | + | 27760321 | HT29 | viability after 22 days | AGACCTGAAGTTGGACCTCGGG | KDM8 | ENSG00000155666 | -0.6445475365194758 | [480,375] | [142,435,376] | -5 | hSpCas9 | negative selection | 4996010 | 27210285 | 27210307 | 16 | + | 27760321 | HT29 | viability after 22 days | GCTCTTCTACGAGGGCAGGAGG | KDM8 | ENSG00000155666 | -2.5266587349048404 | [511,399] | [159,84,26] | -8 | hSpCas9 | negative selection | 4996011 | 27210354 | 27210376 | 16 | + | 27760321 | HT29 | viability after 22 days | GAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -0.7926908673366996 | [455,355] | [297,253,259] | -6 | hSpCas9 | negative selection | 4996012 | 27210479 | 27210501 | 16 | + | 27760321 | HT29 | viability after 22 days | CCCTGCGGGTCTGTGACATGGG | KDM8 | ENSG00000155666 | -2.185976379155876 | [568,443] | [117,172,94] | -8 | hSpCas9 | negative selection | 4996013 | 27210534 | 27210556 | 16 | - | 27760321 | HT29 | viability after 22 days | GATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -2.6804368348101475 | [178,139] | [2,54,28] | -8 | hSpCas9 | negative selection | 4996014 | 27210216 | 27210238 | 16 | + | 27760321 | HT29 | viability after 19 days | AGACCTGAAGTTGGACCTCGGG | KDM8 | ENSG00000155666 | -0.5488093452657827 | [480,375] | [381,485,148] | -5 | hSpCas9 | negative selection | 5079473 | 27210285 | 27210307 | 16 | + | 27760321 | HT29 | viability after 19 days | GCTCTTCTACGAGGGCAGGAGG | KDM8 | ENSG00000155666 | -1.4430328569045427 | [511,399] | [237,252,92] | -7 | hSpCas9 | negative selection | 5079474 | 27210354 | 27210376 | 16 | + | 27760321 | HT29 | viability after 19 days | GAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -0.8892763576614111 | [455,355] | [411,84,270] | -6 | hSpCas9 | negative selection | 5079475 | 27210479 | 27210501 | 16 | + | 27760321 | HT29 | viability after 19 days | CCCTGCGGGTCTGTGACATGGG | KDM8 | ENSG00000155666 | -1.211623631041727 | [568,443] | [507,201,73] | -7 | hSpCas9 | negative selection | 5079476 | 27210534 | 27210556 | 16 | - | 27760321 | HT29 | viability after 19 days | GATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -2.3379665454397065 | [178,139] | [71,30,9] | -8 | hSpCas9 | negative selection | 5079477 | 27210216 | 27210238 | 16 | + | 27760321 | HT29 | viability after 16 days | AGACCTGAAGTTGGACCTCGGG | KDM8 | ENSG00000155666 | -0.13183595618248517 | [480,375] | [350,609,338] | -1 | hSpCas9 | negative selection | 5162936 | 27210285 | 27210307 | 16 | + | 27760321 | HT29 | viability after 16 days | GCTCTTCTACGAGGGCAGGAGG | KDM8 | ENSG00000155666 | -0.7457212373063777 | [511,399] | [377,293,247] | -6 | hSpCas9 | negative selection | 5162937 | 27210354 | 27210376 | 16 | + | 27760321 | HT29 | viability after 16 days | GAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -0.15063595875419494 | [455,355] | [508,216,515] | -1 | hSpCas9 | negative selection | 5162938 | 27210479 | 27210501 | 16 | + | 27760321 | HT29 | viability after 16 days | CCCTGCGGGTCTGTGACATGGG | KDM8 | ENSG00000155666 | -1.306467895246914 | [568,443] | [351,186,160] | -7 | hSpCas9 | negative selection | 5162939 | 27210534 | 27210556 | 16 | - | 27760321 | HT29 | viability after 16 days | GATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -1.7795140162783432 | [178,139] | [112,40,7] | -8 | hSpCas9 | negative selection | 5162940 | 27210216 | 27210238 | 16 | + | 27760321 | HT29 | viability after 13 days | AGACCTGAAGTTGGACCTCGGG | KDM8 | ENSG00000155666 | 0.14221347234044046 | [480,375] | [606,647,399] | 1 | hSpCas9 | negative selection | 5246399 | 27210285 | 27210307 | 16 | + | 27760321 | HT29 | viability after 13 days | GCTCTTCTACGAGGGCAGGAGG | KDM8 | ENSG00000155666 | -0.6315025166214989 | [511,399] | [250,335,431] | -6 | hSpCas9 | negative selection | 5246400 | 27210354 | 27210376 | 16 | + | 27760321 | HT29 | viability after 13 days | GAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | 0.25972696424278596 | [455,355] | [465,680,545] | 3 | hSpCas9 | negative selection | 5246401 | 27210479 | 27210501 | 16 | + | 27760321 | HT29 | viability after 13 days | CCCTGCGGGTCTGTGACATGGG | KDM8 | ENSG00000155666 | -0.32594450896764404 | [568,443] | [532,198,661] | -4 | hSpCas9 | negative selection | 5246402 | 27210534 | 27210556 | 16 | - | 27760321 | HT29 | viability after 13 days | GATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -0.6302504670368554 | [178,139] | [121,139,97] | -6 | hSpCas9 | negative selection | 5246403 | 27210216 | 27210238 | 16 | + | 27760321 | HT29 | viability after 10 days | AGACCTGAAGTTGGACCTCGGG | KDM8 | ENSG00000155666 | 0.2947051453990435 | [480,375] | [802,773,400] | 4 | hSpCas9 | negative selection | 5329862 | 27210285 | 27210307 | 16 | + | 27760321 | HT29 | viability after 10 days | GCTCTTCTACGAGGGCAGGAGG | KDM8 | ENSG00000155666 | 0.020538998019785537 | [511,399] | [605,433,685] | 0 | hSpCas9 | negative selection | 5329863 | 27210354 | 27210376 | 16 | + | 27760321 | HT29 | viability after 10 days | GAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | 0.49072234487233823 | [455,355] | [669,514,940] | 6 | hSpCas9 | negative selection | 5329864 | 27210479 | 27210501 | 16 | + | 27760321 | HT29 | viability after 10 days | CCCTGCGGGTCTGTGACATGGG | KDM8 | ENSG00000155666 | 0.06060638622263165 | [568,443] | [622,686,668] | 0 | hSpCas9 | negative selection | 5329865 | 27210534 | 27210556 | 16 | - | 27760321 | HT29 | viability after 10 days | GATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -0.0895255603339482 | [178,139] | [165,165,227] | -1 | hSpCas9 | negative selection | 5329866 | 27210216 | 27210238 | 16 | + | 27760321 | MOLM13 | viability | AGACCTGAAGTTGGACCTCGGG | KDM8 | ENSG00000155666 | -0.7767163125690795 | [573,480] | [212,138] | -5 | hSpCas9 | negative selection | 5413325 | 27210285 | 27210307 | 16 | + | 27760321 | MOLM13 | viability | GCTCTTCTACGAGGGCAGGAGG | KDM8 | ENSG00000155666 | -1.3415327269110817 | [523,511] | [73,150] | -6 | hSpCas9 | negative selection | 5413326 | 27210354 | 27210376 | 16 | + | 27760321 | MOLM13 | viability | GAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | 1.008948048682628 | [602,455] | [248,891] | 7 | hSpCas9 | negative selection | 5413327 | 27210479 | 27210501 | 16 | + | 27760321 | MOLM13 | viability | CCCTGCGGGTCTGTGACATGGG | KDM8 | ENSG00000155666 | -0.7392486511066496 | [544,568] | [98,265] | -4 | hSpCas9 | negative selection | 5413328 | 27210534 | 27210556 | 16 | - | 27760321 | MOLM13 | viability | GATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -1.5102555359946241 | [242,178] | [82,5] | -7 | hSpCas9 | negative selection | 5413329 | 27203523 | 27203546 | 16 | + | 27661255 | K562 | viability | GATACTCCTATGCTAGCCTCTGG | KDM8 | ENSG00000155666 | 0.011074974936524873 | [332,427] | [366,251] | 0 | dCas9-KRAB | negative selection | 5488248 | 27204015 | 27204038 | 16 | - | 27661255 | K562 | viability | GGCTGGTTGCCTAAAAGCAGCGG | KDM8 | ENSG00000155666 | -0.7366267593576865 | [339,490] | [212,184] | -8 | dCas9-KRAB | negative selection | 5488249 | 27215945 | 27215968 | 16 | - | 27260156 | BXPC3 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.44328189627241366 | [539] | [310,465,396,502] | -7 | hSpCas9 | negative selection | 5550678 | 27215936 | 27215959 | 16 | + | 27260156 | BXPC3 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.07888416907618989 | [116] | [102,108,133,118] | -2 | hSpCas9 | negative selection | 5550679 | 27215945 | 27215968 | 16 | - | 27260156 | A673 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.35645085950264976 | [539] | [521,480,475,550] | -7 | hSpCas9 | negative selection | 5671929 | 27215936 | 27215959 | 16 | + | 27260156 | A673 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.5028909368354593 | [116] | [125,129,89,49] | -8 | hSpCas9 | negative selection | 5671930 | 27215945 | 27215968 | 16 | - | 27260156 | A375 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -1.1650062779436916 | [539] | [277,419,216,233] | -8 | hSpCas9 | negative selection | 5793180 | 27215936 | 27215959 | 16 | + | 27260156 | A375 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -1.7148555157941185 | [116] | [9,105,25,33] | -9 | hSpCas9 | negative selection | 5793181 | 27215945 | 27215968 | 16 | - | 27260156 | COLO741 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.2537398014468999 | [539] | [683,543,519] | -5 | hSpCas9 | negative selection | 5914431 | 27215936 | 27215959 | 16 | + | 27260156 | COLO741 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.35141524958220494 | [116] | [162,115,78] | -6 | hSpCas9 | negative selection | 5914432 | 27215945 | 27215968 | 16 | - | 27260156 | CAL120 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.5500780667944956 | [539] | [499,489,393] | -7 | hSpCas9 | negative selection | 6035682 | 27215936 | 27215959 | 16 | + | 27260156 | CAL120 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.6392258547467864 | [116] | [105,66,108] | -7 | hSpCas9 | negative selection | 6035683 | 27215945 | 27215968 | 16 | - | 27260156 | CADOES1 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.45776813402122307 | [539] | [358,319,484,295] | -7 | hSpCas9 | negative selection | 6156933 | 27215936 | 27215959 | 16 | + | 27260156 | CADOES1 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.1832276352534401 | [116] | [102,168,53,55] | -3 | hSpCas9 | negative selection | 6156934 | 27215945 | 27215968 | 16 | - | 27260156 | EWS502 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.2360952256322808 | [539] | [410,625,355,553] | -4 | hSpCas9 | negative selection | 6278184 | 27215936 | 27215959 | 16 | + | 27260156 | EWS502 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -1.005348982191459 | [116] | [54,53,93,43] | -8 | hSpCas9 | negative selection | 6278185 | 27215945 | 27215968 | 16 | - | 27260156 | EW8 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.7664102544864677 | [539] | [351,226,213,252] | -8 | hSpCas9 | negative selection | 6399435 | 27215936 | 27215959 | 16 | + | 27260156 | EW8 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.9997102703186131 | [116] | [65,20,67,32] | -9 | hSpCas9 | negative selection | 6399436 | 27215945 | 27215968 | 16 | - | 27260156 | CORL105 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.35126011060176165 | [539] | [409,504,547,523] | -6 | hSpCas9 | negative selection | 6520686 | 27215936 | 27215959 | 16 | + | 27260156 | CORL105 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.4360332041318036 | [116] | [114,58,112,120] | -7 | hSpCas9 | negative selection | 6520687 | 27215945 | 27215968 | 16 | - | 27260156 | HS294T | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.15250783299660325 | [539] | [141,141,173,320] | -2 | hSpCas9 | negative selection | 6641937 | 27215936 | 27215959 | 16 | + | 27260156 | HS294T | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.9069364721497717 | [116] | [24,13,31,25] | -8 | hSpCas9 | negative selection | 6641938 | 27215945 | 27215968 | 16 | - | 27260156 | HCC44 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.6781149121069158 | [539] | [545,214,500,322] | -7 | hSpCas9 | negative selection | 6763188 | 27215936 | 27215959 | 16 | + | 27260156 | HCC44 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.5084011003520303 | [116] | [26,135,138,65] | -6 | hSpCas9 | negative selection | 6763189 | 27215945 | 27215968 | 16 | - | 27260156 | G402 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.6387407602214139 | [539] | [192,285,515,643] | -7 | hSpCas9 | negative selection | 6884439 | 27215936 | 27215959 | 16 | + | 27260156 | G402 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.6897491321997511 | [116] | [72,17,223,34] | -7 | hSpCas9 | negative selection | 6884440 | 27215945 | 27215968 | 16 | - | 27260156 | L33 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | 0.16149126606919897 | [539] | [532,284,329,662] | 3 | hSpCas9 | negative selection | 7005690 | 27215936 | 27215959 | 16 | + | 27260156 | L33 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | 0.2946452255355909 | [116] | [113,64,115,117] | 6 | hSpCas9 | negative selection | 7005691 | 27215945 | 27215968 | 16 | - | 27260156 | K562 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.16605848575486057 | [539] | [419,492,477,329] | -2 | hSpCas9 | negative selection | 7126941 | 27215936 | 27215959 | 16 | + | 27260156 | K562 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.425181876297517 | [116] | [83,149,45,37] | -5 | hSpCas9 | negative selection | 7126942 | 27215945 | 27215968 | 16 | - | 27260156 | HT29 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.520304442700042 | [539] | [538,543,344,417] | -7 | hSpCas9 | negative selection | 7248192 | 27215936 | 27215959 | 16 | + | 27260156 | HT29 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.7329510018933436 | [116] | [74,164,42,66] | -8 | hSpCas9 | negative selection | 7248193 | 27215945 | 27215968 | 16 | - | 27260156 | MHHES1 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.3227539575042771 | [539] | [477,495,616,370] | -6 | hSpCas9 | negative selection | 7369443 | 27215936 | 27215959 | 16 | + | 27260156 | MHHES1 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.33550668269964934 | [116] | [142,150,24,104] | -6 | hSpCas9 | negative selection | 7369444 | 27215945 | 27215968 | 16 | - | 27260156 | MEWO | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.2996171816806268 | [539] | [424,432,375] | -6 | hSpCas9 | negative selection | 7490694 | 27215936 | 27215959 | 16 | + | 27260156 | MEWO | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.010201065977100132 | [116] | [133,97,98] | 0 | hSpCas9 | negative selection | 7490695 | 27215945 | 27215968 | 16 | - | 27260156 | LNCAPCLONEFGC | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.58558002129866 | [539] | [307,291,357,352] | -7 | hSpCas9 | negative selection | 7611945 | 27215936 | 27215959 | 16 | + | 27260156 | LNCAPCLONEFGC | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.36131443621908943 | [116] | [53,68,72,133] | -5 | hSpCas9 | negative selection | 7611946 | 27215945 | 27215968 | 16 | - | 27260156 | PANC0327 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.3799814801668083 | [539] | [326,585,365,163] | -5 | hSpCas9 | negative selection | 7733196 | 27215936 | 27215959 | 16 | + | 27260156 | PANC0327 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -1.3693939949726959 | [116] | [47,43,16,51] | -9 | hSpCas9 | negative selection | 7733197 | 27215945 | 27215968 | 16 | - | 27260156 | NCIH2009 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.9382043139842264 | [539] | [627,385,212] | -8 | hSpCas9 | negative selection | 7854447 | 27215936 | 27215959 | 16 | + | 27260156 | NCIH2009 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -1.0858734176881817 | [116] | [48,41,134] | -8 | hSpCas9 | negative selection | 7854448 | 27215945 | 27215968 | 16 | - | 27260156 | NCIH1373 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.6728095413131115 | [539] | [214,252,513,138] | -6 | hSpCas9 | negative selection | 7975698 | 27215936 | 27215959 | 16 | + | 27260156 | NCIH1373 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.9599146657472151 | [116] | [39,39,93,24] | -7 | hSpCas9 | negative selection | 7975699 | 27215945 | 27215968 | 16 | - | 27260156 | PATU8902 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -1.0233636368351113 | [539] | [348,520,271,359] | -7 | hSpCas9 | negative selection | 8096949 | 27215936 | 27215959 | 16 | + | 27260156 | PATU8902 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.1764600533103935 | [116] | [95,279,15,227] | -2 | hSpCas9 | negative selection | 8096950 | 27215945 | 27215968 | 16 | - | 27260156 | PANC1 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.1935683944320979 | [539] | [345,653,190,464] | -3 | hSpCas9 | negative selection | 8218200 | 27215936 | 27215959 | 16 | + | 27260156 | PANC1 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -1.060205749662945 | [116] | [61,39,46,41] | -8 | hSpCas9 | negative selection | 8218201 | 27215945 | 27215968 | 16 | - | 27260156 | PANC0813 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.44515806335559427 | [539] | [544,407,620,305] | -6 | hSpCas9 | negative selection | 8339451 | 27215936 | 27215959 | 16 | + | 27260156 | PANC0813 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -1.5107542825866114 | [116] | [91,27,31,44] | -9 | hSpCas9 | negative selection | 8339452 | 27215945 | 27215968 | 16 | - | 27260156 | RDES | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.06877802366042135 | [539] | [461,610,477,862] | -1 | hSpCas9 | negative selection | 8460702 | 27215936 | 27215959 | 16 | + | 27260156 | RDES | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | 0.22813137931718308 | [116] | [116,174,145,200] | 3 | hSpCas9 | negative selection | 8460703 | 27215945 | 27215968 | 16 | - | 27260156 | PC3 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | 0.3008859751090107 | [539] | [398,792,870,716] | 6 | hSpCas9 | negative selection | 8581953 | 27215936 | 27215959 | 16 | + | 27260156 | PC3 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.16521409768659945 | [116] | [33,116,170,145] | -4 | hSpCas9 | negative selection | 8581954 | 27215945 | 27215968 | 16 | - | 27260156 | PATU8988T | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.8246605294027199 | [539] | [262,437,257,227] | -8 | hSpCas9 | negative selection | 8703204 | 27215936 | 27215959 | 16 | + | 27260156 | PATU8988T | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -1.4617624850577102 | [116] | [14,8,118,14] | -9 | hSpCas9 | negative selection | 8703205 | 27215945 | 27215968 | 16 | - | 27260156 | T47D | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.2347188859245106 | [539] | [565,474,509,594] | -5 | hSpCas9 | negative selection | 8824455 | 27215936 | 27215959 | 16 | + | 27260156 | T47D | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.27654130112594766 | [116] | [83,178,65,115] | -6 | hSpCas9 | negative selection | 8824456 | 27215945 | 27215968 | 16 | - | 27260156 | SU8686 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.14161128301320042 | [539] | [529,443,376,602] | -2 | hSpCas9 | negative selection | 8945706 | 27215936 | 27215959 | 16 | + | 27260156 | SU8686 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.7234346002032175 | [116] | [80,67,42,89] | -8 | hSpCas9 | negative selection | 8945707 | 27215945 | 27215968 | 16 | - | 27260156 | SKES1 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.0724640476724368 | [539] | [431,700,581,357] | -1 | hSpCas9 | negative selection | 9066957 | 27215936 | 27215959 | 16 | + | 27260156 | SKES1 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.012823768466974972 | [116] | [197,135,93,54] | 0 | hSpCas9 | negative selection | 9066958 | 27215945 | 27215968 | 16 | - | 27260156 | TOV112D | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.23152500052637814 | [539] | [796,393,355,310] | -4 | hSpCas9 | negative selection | 9188208 | 27215936 | 27215959 | 16 | + | 27260156 | TOV112D | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.41432002293086523 | [116] | [79,113,99,63] | -7 | hSpCas9 | negative selection | 9188209 | 27215945 | 27215968 | 16 | - | 27260156 | TC71 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.09179350719496895 | [539] | [533,538,569,527] | -2 | hSpCas9 | negative selection | 9309459 | 27215936 | 27215959 | 16 | + | 27260156 | TC71 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | -0.45743206888171883 | [116] | [62,60,99,144] | -8 | hSpCas9 | negative selection | 9309460 | 27215945 | 27215968 | 16 | - | 27260156 | TC32 | viability | GCAAGGTACCCGACGTCCCTTGG | KDM8 | ENSG00000155666 | -0.2386819690323364 | [539] | [399,324,491,537] | -4 | hSpCas9 | negative selection | 9430710 | 27215936 | 27215959 | 16 | + | 27260156 | TC32 | viability | GTGGATTAGCCAAGGGACGTCGG | KDM8 | ENSG00000155666 | 0.03925155873047226 | [116] | [73,47,258,120] | 0 | hSpCas9 | negative selection | 9430711 | 27210353 | 27210376 | 16 | + | 27869803 | HPAFII | viability after 27 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -1.465019655783385 | [231] | [41,45,NaN] | -7 | hSpCas9 | negative selection | 9556362 | 27215974 | 27215997 | 16 | - | 27869803 | HPAFII | viability after 27 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -1.8828820510932163 | [168] | [28,19,NaN] | -8 | hSpCas9 | negative selection | 9556363 | 27220467 | 27220490 | 16 | + | 27869803 | HPAFII | viability after 27 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 0.2793153717460294 | [215] | [283,15,NaN] | 2 | hSpCas9 | negative selection | 9556364 | 27220652 | 27220675 | 16 | - | 27869803 | HPAFII | viability after 27 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | -0.219445843492738 | [151] | [66,69,NaN] | -2 | hSpCas9 | negative selection | 9556365 | 27210353 | 27210376 | 16 | + | 27869803 | HPAFII | viability after 15 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -0.9237924444874379 | [231] | [107,145,NaN] | -7 | hSpCas9 | negative selection | 9638811 | 27215974 | 27215997 | 16 | - | 27869803 | HPAFII | viability after 15 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -0.9780261813603538 | [168] | [180,36,NaN] | -7 | hSpCas9 | negative selection | 9638812 | 27220467 | 27220490 | 16 | + | 27869803 | HPAFII | viability after 15 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 0.0012929516830711418 | [215] | [404,124,NaN] | 0 | hSpCas9 | negative selection | 9638813 | 27220652 | 27220675 | 16 | - | 27869803 | HPAFII | viability after 15 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | 0.11033670646174853 | [151] | [274,114,NaN] | 1 | hSpCas9 | negative selection | 9638814 | 27210353 | 27210376 | 16 | + | 27869803 | ASPC1 | viability after 36 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | 0.08772371122514011 | [412] | [179,191,101] | 0 | hSpCas9 | negative selection | 9721260 | 27215974 | 27215997 | 16 | - | 27869803 | ASPC1 | viability after 36 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -0.49926395463718054 | [455] | [308,23,43] | -5 | hSpCas9 | negative selection | 9721261 | 27220467 | 27220490 | 16 | + | 27869803 | ASPC1 | viability after 36 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | -0.027825194943935982 | [345] | [208,102,65] | 0 | hSpCas9 | negative selection | 9721262 | 27220652 | 27220675 | 16 | - | 27869803 | ASPC1 | viability after 36 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | 0.02370174049520557 | [476] | [216,264,57] | 0 | hSpCas9 | negative selection | 9721263 | 27210353 | 27210376 | 16 | + | 27869803 | PATU8988S | viability after 35 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -1.4195549623070947 | [418] | [99,25,NaN] | -8 | hSpCas9 | negative selection | 9803709 | 27215974 | 27215997 | 16 | - | 27869803 | PATU8988S | viability after 35 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -0.46189916302025025 | [312] | [101,80,NaN] | -5 | hSpCas9 | negative selection | 9803710 | 27220467 | 27220490 | 16 | + | 27869803 | PATU8988S | viability after 35 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 0.06364598997361592 | [421] | [232,121,NaN] | 0 | hSpCas9 | negative selection | 9803711 | 27220652 | 27220675 | 16 | - | 27869803 | PATU8988S | viability after 35 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | -1.3716903366543933 | [445] | [31,106,NaN] | -8 | hSpCas9 | negative selection | 9803712 | 27210353 | 27210376 | 16 | + | 27869803 | PATU8988S | viability after 31 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -0.5672032993991581 | [418] | [121,100,NaN] | -6 | hSpCas9 | negative selection | 9886158 | 27215974 | 27215997 | 16 | - | 27869803 | PATU8988S | viability after 31 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -0.7921280330594467 | [312] | [46,103,NaN] | -7 | hSpCas9 | negative selection | 9886159 | 27220467 | 27220490 | 16 | + | 27869803 | PATU8988S | viability after 31 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 0.25360124515343296 | [421] | [237,152,NaN] | 3 | hSpCas9 | negative selection | 9886160 | 27220652 | 27220675 | 16 | - | 27869803 | PATU8988S | viability after 31 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | -0.8721946504096352 | [445] | [79,118,NaN] | -7 | hSpCas9 | negative selection | 9886161 | 27210353 | 27210376 | 16 | + | 27869803 | HPAFII | viability after 35 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -2.6463896316312594 | [231] | [6,31,NaN] | -8 | hSpCas9 | negative selection | 9968607 | 27215974 | 27215997 | 16 | - | 27869803 | HPAFII | viability after 35 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -2.2067198942589985 | [168] | [26,8,NaN] | -8 | hSpCas9 | negative selection | 9968608 | 27220467 | 27220490 | 16 | + | 27869803 | HPAFII | viability after 35 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 0.9244296249830752 | [215] | [342,54,NaN] | 6 | hSpCas9 | negative selection | 9968609 | 27220652 | 27220675 | 16 | - | 27869803 | HPAFII | viability after 35 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | 0.12430450066090659 | [151] | [65,103,NaN] | 0 | hSpCas9 | negative selection | 9968610 | 27210353 | 27210376 | 16 | + | 27869803 | HPAFII | viability after 31 days | AGAAGCTCAACACGGGCACATGG | KDM8 | ENSG00000155666 | -2.8748626759476323 | [231] | [0,35,NaN] | -8 | hSpCas9 | negative selection | 10051056 | 27215974 | 27215997 | 16 | - | 27869803 | HPAFII | viability after 31 days | GACTTACCTGGTCAAAGAGCTGG | KDM8 | ENSG00000155666 | -2.0996698247623247 | [168] | [24,18,NaN] | -8 | hSpCas9 | negative selection | 10051057 | 27220467 | 27220490 | 16 | + | 27869803 | HPAFII | viability after 31 days | TCTCCATAACACGAGCCAGGTGG | KDM8 | ENSG00000155666 | 0.982236456497129 | [215] | [439,20,NaN] | 7 | hSpCas9 | negative selection | 10051058 | 27220652 | 27220675 | 16 | - | 27869803 | HPAFII | viability after 31 days | AGTATTTCACCGGGATGAACAGG | KDM8 | ENSG00000155666 | -0.08722823113837574 | [151] | [86,72,NaN] | 0 | hSpCas9 | negative selection | 10051059 | 27219054 | 27219077 | 16 | - | 28162770 | P31FUJ | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -2.3514467009129976 | [151] | [34] | -8 | hSpCas9 | negative selection | 10178652 | 27210185 | 27210208 | 16 | - | 28162770 | P31FUJ | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -0.1535389258897254 | [300] | [317] | -1 | hSpCas9 | negative selection | 10178653 | 27210237 | 27210260 | 16 | + | 28162770 | P31FUJ | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -1.882615849485503 | [90] | [28] | -8 | hSpCas9 | negative selection | 10178654 | 27210309 | 27210332 | 16 | + | 28162770 | P31FUJ | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | -3.5096424097732033 | [125] | [12] | -9 | hSpCas9 | negative selection | 10178655 | 27210534 | 27210557 | 16 | - | 28162770 | P31FUJ | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -0.3859589924757991 | [138] | [124] | -3 | hSpCas9 | negative selection | 10178656 | 27219054 | 27219077 | 16 | - | 28162770 | TF1 | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | NaN | [NaN] | [15] | 1 | hSpCas9 | negative selection | 10348018 | 27210185 | 27210208 | 16 | - | 28162770 | TF1 | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | NaN | [NaN] | [53] | 1 | hSpCas9 | negative selection | 10348019 | 27210237 | 27210260 | 16 | + | 28162770 | TF1 | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | NaN | [NaN] | [0] | 1 | hSpCas9 | negative selection | 10348020 | 27210309 | 27210332 | 16 | + | 28162770 | TF1 | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | NaN | [NaN] | [0] | 1 | hSpCas9 | negative selection | 10348021 | 27210534 | 27210557 | 16 | - | 28162770 | TF1 | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | NaN | [NaN] | [54] | 1 | hSpCas9 | negative selection | 10348022 | 27219054 | 27219077 | 16 | - | 28162770 | SKM1 | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -2.0443941193584534 | [34] | [14] | -8 | hSpCas9 | negative selection | 10517384 | 27210185 | 27210208 | 16 | - | 28162770 | SKM1 | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -1.8551685619572047 | [87] | [42] | -8 | hSpCas9 | negative selection | 10517385 | 27210237 | 27210260 | 16 | + | 28162770 | SKM1 | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -4.345563654079018 | [45] | [3] | -9 | hSpCas9 | negative selection | 10517386 | 27210309 | 27210332 | 16 | + | 28162770 | SKM1 | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | -1.3000489948266498 | [38] | [27] | -7 | hSpCas9 | negative selection | 10517387 | 27210534 | 27210557 | 16 | - | 28162770 | SKM1 | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -1.0110355224120224 | [56] | [49] | -6 | hSpCas9 | negative selection | 10517388 | 27219054 | 27219077 | 16 | - | 28162770 | SKM1 | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -2.0443941193584534 | [34] | [14] | -8 | hSpCas9 | negative selection | 10686750 | 27210185 | 27210208 | 16 | - | 28162770 | SKM1 | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -1.8551685619572047 | [87] | [42] | -8 | hSpCas9 | negative selection | 10686751 | 27210237 | 27210260 | 16 | + | 28162770 | SKM1 | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -4.345563654079018 | [45] | [3] | -9 | hSpCas9 | negative selection | 10686752 | 27210309 | 27210332 | 16 | + | 28162770 | SKM1 | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | -1.3000489948266498 | [38] | [27] | -7 | hSpCas9 | negative selection | 10686753 | 27210534 | 27210557 | 16 | - | 28162770 | SKM1 | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -1.0110355224120224 | [56] | [49] | -6 | hSpCas9 | negative selection | 10686754 | 27219054 | 27219077 | 16 | - | 28162770 | PL21 | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -0.787369441327483 | [114] | [28] | -5 | hSpCas9 | negative selection | 10856116 | 27210185 | 27210208 | 16 | - | 28162770 | PL21 | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -0.41483545529827576 | [339] | [110] | -3 | hSpCas9 | negative selection | 10856117 | 27210237 | 27210260 | 16 | + | 28162770 | PL21 | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -2.030158004932474 | [121] | [12] | -8 | hSpCas9 | negative selection | 10856118 | 27210309 | 27210332 | 16 | + | 28162770 | PL21 | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | 0.420908293346104 | [126] | [73] | 3 | hSpCas9 | negative selection | 10856119 | 27210534 | 27210557 | 16 | - | 28162770 | PL21 | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | 0.4307525426307366 | [149] | [87] | 4 | hSpCas9 | negative selection | 10856120 | 27219054 | 27219077 | 16 | - | 28162770 | P31FUJ | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -2.3514467009129976 | [151] | [34] | -8 | hSpCas9 | negative selection | 11025482 | 27210185 | 27210208 | 16 | - | 28162770 | P31FUJ | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -0.1535389258897254 | [300] | [317] | -1 | hSpCas9 | negative selection | 11025483 | 27210237 | 27210260 | 16 | + | 28162770 | P31FUJ | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -1.882615849485503 | [90] | [28] | -8 | hSpCas9 | negative selection | 11025484 | 27210309 | 27210332 | 16 | + | 28162770 | P31FUJ | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | -3.5096424097732033 | [125] | [12] | -9 | hSpCas9 | negative selection | 11025485 | 27210534 | 27210557 | 16 | - | 28162770 | P31FUJ | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -0.3859589924757991 | [138] | [124] | -3 | hSpCas9 | negative selection | 11025486 | 27219054 | 27219077 | 16 | - | 28162770 | OCIAML5 | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -0.9154919510056307 | [92] | [88] | -5 | hSpCas9 | negative selection | 11194848 | 27210185 | 27210208 | 16 | - | 28162770 | OCIAML5 | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -0.019620667843562423 | [113] | [202] | 0 | hSpCas9 | negative selection | 11194849 | 27210237 | 27210260 | 16 | + | 28162770 | OCIAML5 | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -6.7100475659915695 | [57] | [0] | -9 | hSpCas9 | negative selection | 11194850 | 27210309 | 27210332 | 16 | + | 28162770 | OCIAML5 | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | -4.530138475976634 | [63] | [4] | -9 | hSpCas9 | negative selection | 11194851 | 27210534 | 27210557 | 16 | - | 28162770 | OCIAML5 | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -1.936600081075665 | [122] | [57] | -8 | hSpCas9 | negative selection | 11194852 | 27219054 | 27219077 | 16 | - | 28162770 | EOL1 | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -0.23017482322810756 | [117] | [52] | -2 | hSpCas9 | negative selection | 11364214 | 27210185 | 27210208 | 16 | - | 28162770 | EOL1 | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -1.9897223544035814 | [587] | [77] | -8 | hSpCas9 | negative selection | 11364215 | 27210237 | 27210260 | 16 | + | 28162770 | EOL1 | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -2.051204682182788 | [235] | [29] | -8 | hSpCas9 | negative selection | 11364216 | 27210309 | 27210332 | 16 | + | 28162770 | EOL1 | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | -2.386239765711627 | [257] | [25] | -8 | hSpCas9 | negative selection | 11364217 | 27210534 | 27210557 | 16 | - | 28162770 | EOL1 | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -0.6432905513594127 | [334] | [112] | -5 | hSpCas9 | negative selection | 11364218 | 27219054 | 27219077 | 16 | - | 28162770 | MOLM13 | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -2.5484124307845217 | [177] | [21] | -8 | hSpCas9 | negative selection | 11533580 | 27210185 | 27210208 | 16 | - | 28162770 | MOLM13 | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | 0.32948576727513523 | [480] | [436] | 2 | hSpCas9 | negative selection | 11533581 | 27210237 | 27210260 | 16 | + | 28162770 | MOLM13 | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -3.1468204625706293 | [146] | [11] | -8 | hSpCas9 | negative selection | 11533582 | 27210309 | 27210332 | 16 | + | 28162770 | MOLM13 | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | -3.4746251237946613 | [122] | [7] | -8 | hSpCas9 | negative selection | 11533583 | 27210534 | 27210557 | 16 | - | 28162770 | MOLM13 | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -1.091872565051435 | [226] | [76] | -5 | hSpCas9 | negative selection | 11533584 | 27219054 | 27219077 | 16 | - | 28162770 | HEL | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -3.492420751281279 | [122] | [6] | -9 | hSpCas9 | negative selection | 11702946 | 27210185 | 27210208 | 16 | - | 28162770 | HEL | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -0.4399484503019095 | [376] | [177] | -3 | hSpCas9 | negative selection | 11702947 | 27210237 | 27210260 | 16 | + | 28162770 | HEL | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -2.36783040970983 | [136] | [16] | -8 | hSpCas9 | negative selection | 11702948 | 27210309 | 27210332 | 16 | + | 28162770 | HEL | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | -2.950785682224223 | [168] | [13] | -8 | hSpCas9 | negative selection | 11702949 | 27210534 | 27210557 | 16 | - | 28162770 | HEL | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -0.4166940815188009 | [222] | [106] | -3 | hSpCas9 | negative selection | 11702950 | 27219054 | 27219077 | 16 | - | 28162770 | MV411 | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -2.967575340188075 | [129] | [13] | -9 | hSpCas9 | negative selection | 11872312 | 27210185 | 27210208 | 16 | - | 28162770 | MV411 | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -0.24256200617729062 | [315] | [224] | -2 | hSpCas9 | negative selection | 11872313 | 27210237 | 27210260 | 16 | + | 28162770 | MV411 | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -3.8229517771086226 | [83] | [4] | -9 | hSpCas9 | negative selection | 11872314 | 27210309 | 27210332 | 16 | + | 28162770 | MV411 | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | -1.2423677168980407 | [131] | [46] | -7 | hSpCas9 | negative selection | 11872315 | 27210534 | 27210557 | 16 | - | 28162770 | MV411 | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -1.5715364545416621 | [186] | [52] | -7 | hSpCas9 | negative selection | 11872316 | 27219054 | 27219077 | 16 | - | 28162770 | MONOMAC1 | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -1.7599730414507109 | [64] | [21] | -8 | hSpCas9 | negative selection | 12041678 | 27210185 | 27210208 | 16 | - | 28162770 | MONOMAC1 | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -0.37909717436078333 | [193] | [170] | -3 | hSpCas9 | negative selection | 12041679 | 27210237 | 27210260 | 16 | + | 28162770 | MONOMAC1 | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -1.103927442668072 | [74] | [39] | -7 | hSpCas9 | negative selection | 12041680 | 27210309 | 27210332 | 16 | + | 28162770 | MONOMAC1 | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | -0.21614567000725837 | [75] | [74] | -2 | hSpCas9 | negative selection | 12041681 | 27210534 | 27210557 | 16 | - | 28162770 | MONOMAC1 | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -0.8250680696725959 | [118] | [76] | -6 | hSpCas9 | negative selection | 12041682 | 27219054 | 27219077 | 16 | - | 28162770 | OCIAML2 | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -2.807664812519732 | [23] | [18] | -9 | hSpCas9 | negative selection | 12211044 | 27210185 | 27210208 | 16 | - | 28162770 | OCIAML2 | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -1.019968416232596 | [59] | [163] | -6 | hSpCas9 | negative selection | 12211045 | 27210237 | 27210260 | 16 | + | 28162770 | OCIAML2 | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -2.400240497350763 | [19] | [20] | -8 | hSpCas9 | negative selection | 12211046 | 27210309 | 27210332 | 16 | + | 28162770 | OCIAML2 | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | -2.8665585015733006 | [24] | [18] | -9 | hSpCas9 | negative selection | 12211047 | 27210534 | 27210557 | 16 | - | 28162770 | OCIAML2 | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | -2.1227065218218546 | [43] | [55] | -8 | hSpCas9 | negative selection | 12211048 | 27219054 | 27219077 | 16 | - | 28162770 | OCIAML3 | viability | AGTGGGGAGATGGTTCCCTGGGG | KDM8 | ENSG00000155666 | -2.272079545436801 | [31] | [19] | -8 | hSpCas9 | negative selection | 12380410 | 27210185 | 27210208 | 16 | - | 28162770 | OCIAML3 | viability | GTGCGGCAGGAGCGCCCTGAGGG | KDM8 | ENSG00000155666 | -1.3716152189877153 | [95] | [111] | -7 | hSpCas9 | negative selection | 12380411 | 27210237 | 27210260 | 16 | + | 28162770 | OCIAML3 | viability | GGAGAAAGTGGAGAGGAGCGTGG | KDM8 | ENSG00000155666 | -1.9159357352115254 | [19] | [15] | -8 | hSpCas9 | negative selection | 12380412 | 27210309 | 27210332 | 16 | + | 28162770 | OCIAML3 | viability | CGAGTGTCTGCAGAGCAGCGAGG | KDM8 | ENSG00000155666 | -1.5236183124327651 | [39] | [41] | -8 | hSpCas9 | negative selection | 12380413 | 27210534 | 27210557 | 16 | - | 28162770 | OCIAML3 | viability | GGATGGCAGCGACTTTAAGAAGG | KDM8 | ENSG00000155666 | 0.1929986363416386 | [50] | [175] | 1 | hSpCas9 | negative selection | 12380414 |