Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:23276
• Symbol:KLHL18
• Description:kelch like family member 18

DataSource: http://genomecrispr.dkfz.de/#!/results/KLHL18

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
47282953	47282976	3	+	26472758	Jiyoye	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-2.9246681822465717	[291]	[28]	-9	hSpCas9	negative selection	85292
47333240	47333263	3	-	26472758	Jiyoye	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	1.5182066938946173	[24]	[53]	8	hSpCas9	negative selection	85293
47283042	47283065	3	+	26472758	Jiyoye	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	0.28688114778816165	[49]	[45]	2	hSpCas9	negative selection	85294
47334683	47334706	3	+	26472758	Jiyoye	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	0.5300321292914069	[89]	[97]	4	hSpCas9	negative selection	85295
47282965	47282988	3	+	26472758	Jiyoye	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	1.1937717433966801	[39]	[68]	7	hSpCas9	negative selection	85296
47319676	47319699	3	-	26472758	Jiyoye	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	1.342726673779031	[102]	[196]	7	hSpCas9	negative selection	85297
47333182	47333205	3	+	26472758	Jiyoye	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	2.1296414059769644	[9]	[32]	9	hSpCas9	negative selection	85298
47334775	47334798	3	-	26472758	Jiyoye	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	3.86660700014317	[0]	[10]	9	hSpCas9	negative selection	85299
47336661	47336684	3	+	26472758	Jiyoye	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	0.09647454204176531	[159]	[128]	0	hSpCas9	negative selection	85300
47336677	47336700	3	+	26472758	Jiyoye	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	0.01847827440581007	[198]	[151]	0	hSpCas9	negative selection	85301
47282953	47282976	3	+	26472758	KBM7	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-2.6059714333042594	[1105,585]	[89,39]	-9	hSpCas9	negative selection	276410
47333240	47333263	3	-	26472758	KBM7	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	-0.029843187472348376	[174,188]	[73,93]	0	hSpCas9	negative selection	276411
47283042	47283065	3	+	26472758	KBM7	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	0.6105928028063159	[377,233]	[234,197]	6	hSpCas9	negative selection	276412
47334683	47334706	3	+	26472758	KBM7	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	-0.45173179605287833	[611,491]	[271,113]	-4	hSpCas9	negative selection	276413
47282965	47282988	3	+	26472758	KBM7	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	-0.6668692412674262	[377,215]	[39,126]	-5	hSpCas9	negative selection	276414
47319676	47319699	3	-	26472758	KBM7	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	0.029677685275295684	[1000,828]	[378,488]	0	hSpCas9	negative selection	276415
47333182	47333205	3	+	26472758	KBM7	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	0.04380456723687087	[247,249]	[152,92]	0	hSpCas9	negative selection	276416
47334775	47334798	3	-	26472758	KBM7	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	1.1803392678530722	[16,6]	[15,8]	9	hSpCas9	negative selection	276417
47336661	47336684	3	+	26472758	KBM7	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	-0.09735279967832383	[782,458]	[172,350]	-1	hSpCas9	negative selection	276418
47336677	47336700	3	+	26472758	KBM7	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	-0.0018439847301948697	[772,790]	[398,342]	0	hSpCas9	negative selection	276419
47282953	47282976	3	+	26472758	Raji	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-2.0890136774299037	[494]	[26]	-8	hSpCas9	negative selection	467528
47333240	47333263	3	-	26472758	Raji	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	-0.03309768817623082	[96]	[21]	0	hSpCas9	negative selection	467529
47283042	47283065	3	+	26472758	Raji	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	1.1073835353735995	[101]	[50]	8	hSpCas9	negative selection	467530
47334683	47334706	3	+	26472758	Raji	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	-1.062541466068713	[305]	[33]	-7	hSpCas9	negative selection	467531
47282965	47282988	3	+	26472758	Raji	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	0.3860995634396629	[121]	[36]	3	hSpCas9	negative selection	467532
47319676	47319699	3	-	26472758	Raji	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	0.152153405493622	[348]	[89]	1	hSpCas9	negative selection	467533
47333182	47333205	3	+	26472758	Raji	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	-1.6114347120823471	[78]	[5]	-8	hSpCas9	negative selection	467534
47334775	47334798	3	-	26472758	Raji	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	0.37041794120739313	[29]	[8]	3	hSpCas9	negative selection	467535
47336661	47336684	3	+	26472758	Raji	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	0.05293575135122314	[215]	[51]	0	hSpCas9	negative selection	467536
47336677	47336700	3	+	26472758	Raji	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	0.5466685808991207	[294]	[99]	5	hSpCas9	negative selection	467537
47282953	47282976	3	+	26472758	K562	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-2.1673948707381108	[744]	[139]	-7	hSpCas9	negative selection	658646
47333240	47333263	3	-	26472758	K562	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	0.10404607130189447	[150]	[136]	0	hSpCas9	negative selection	658647
47283042	47283065	3	+	26472758	K562	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	0.6005625378917223	[199]	[255]	5	hSpCas9	negative selection	658648
47334683	47334706	3	+	26472758	K562	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	-3.3594028003060252	[461]	[37]	-8	hSpCas9	negative selection	658649
47282965	47282988	3	+	26472758	K562	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	-0.6815806908897761	[132]	[69]	-4	hSpCas9	negative selection	658650
47319676	47319699	3	-	26472758	K562	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	-0.9906661072731585	[684]	[290]	-5	hSpCas9	negative selection	658651
47333182	47333205	3	+	26472758	K562	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	0.16273493007273898	[108]	[102]	1	hSpCas9	negative selection	658652
47334775	47334798	3	-	26472758	K562	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	0.20594457985181114	[37]	[36]	1	hSpCas9	negative selection	658653
47336661	47336684	3	+	26472758	K562	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	-0.8824933848157728	[569]	[260]	-5	hSpCas9	negative selection	658654
47336677	47336700	3	+	26472758	K562	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	-0.8851140849749084	[721]	[329]	-5	hSpCas9	negative selection	658655
47283047	47283070	3	+	26627737	DLD1	viability	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	-0.2267451392336872	[423]	[198,111,39]	-2	hSpCas9	negative selection	821987
47319730	47319753	3	+	26627737	DLD1	viability	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.5583934163903631	[468]	[217,250,184]	5	hSpCas9	negative selection	821988
47322687	47322710	3	+	26627737	DLD1	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	1.6776585309281176	[0]	[0,0,0]	9	hSpCas9	negative selection	821989
47330089	47330112	3	+	26627737	DLD1	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.024241272459739976	[516]	[285,119,80]	0	hSpCas9	negative selection	821990
47333213	47333236	3	-	26627737	DLD1	viability	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	0.6084446168845165	[173]	[159,70,25]	6	hSpCas9	negative selection	821991
47334759	47334782	3	-	26627737	DLD1	viability	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.06939066601931443	[1412]	[529,496,377]	0	hSpCas9	negative selection	821992
47283047	47283070	3	+	26627737	GBM cells	viability after 5 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	-0.2742008139954246	[282]	[112,137]	-4	hSpCas9	negative selection	904302
47319730	47319753	3	+	26627737	GBM cells	viability after 5 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.3368657661125314	[405]	[279,269]	5	hSpCas9	negative selection	904303
47322687	47322710	3	+	26627737	GBM cells	viability after 5 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.8989138748856851	[0]	[0,0]	9	hSpCas9	negative selection	904304
47330089	47330112	3	+	26627737	GBM cells	viability after 5 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.4523654028616245	[215]	[153,162]	6	hSpCas9	negative selection	904305
47333213	47333236	3	-	26627737	GBM cells	viability after 5 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	-0.2895312145274244	[195]	[96,74]	-4	hSpCas9	negative selection	904306
47334759	47334782	3	-	26627737	GBM cells	viability after 5 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.15366880295491248	[465]	[303,251]	2	hSpCas9	negative selection	904307
47283047	47283070	3	+	26627737	GBM cells	viability after 13 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	-0.6210345905157256	[282]	[122,80]	-6	hSpCas9	negative selection	986617
47319730	47319753	3	+	26627737	GBM cells	viability after 13 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.1963605235068301	[405]	[306,207]	2	hSpCas9	negative selection	986618
47322687	47322710	3	+	26627737	GBM cells	viability after 13 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.8821031235784469	[0]	[0,0]	9	hSpCas9	negative selection	986619
47330089	47330112	3	+	26627737	GBM cells	viability after 13 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.7095790196480143	[215]	[189,192]	8	hSpCas9	negative selection	986620
47333213	47333236	3	-	26627737	GBM cells	viability after 13 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	0.12180335875796802	[195]	[166,73]	1	hSpCas9	negative selection	986621
47334759	47334782	3	-	26627737	GBM cells	viability after 13 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.314394630526984	[465]	[293,330]	4	hSpCas9	negative selection	986622
47283047	47283070	3	+	26627737	GBM cells	viability after 21 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	-0.6791285239561647	[282]	[118,74]	-5	hSpCas9	negative selection	1068932
47319730	47319753	3	+	26627737	GBM cells	viability after 21 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.36920919386697104	[405]	[298,271]	4	hSpCas9	negative selection	1068933
47322687	47322710	3	+	26627737	GBM cells	viability after 21 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.8802332996156581	[0]	[0,0]	8	hSpCas9	negative selection	1068934
47330089	47330112	3	+	26627737	GBM cells	viability after 21 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.27158917076628425	[215]	[137,144]	3	hSpCas9	negative selection	1068935
47333213	47333236	3	-	26627737	GBM cells	viability after 21 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	-0.31925120653273914	[195]	[88,81]	-3	hSpCas9	negative selection	1068936
47334759	47334782	3	-	26627737	GBM cells	viability after 21 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.7252841727090824	[465]	[440,397]	7	hSpCas9	negative selection	1068937
47283047	47283070	3	+	26627737	RPE1	viability after 9 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	-0.005129652777540128	[1019]	[260,391]	0	hSpCas9	negative selection	1151247
47319730	47319753	3	+	26627737	RPE1	viability after 9 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.012958917726337504	[1453]	[395,540]	0	hSpCas9	negative selection	1151248
47322687	47322710	3	+	26627737	RPE1	viability after 9 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	1.6754465303148196	[0]	[0,0]	8	hSpCas9	negative selection	1151249
47330089	47330112	3	+	26627737	RPE1	viability after 9 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.4740896020287061	[1281]	[105,524]	-3	hSpCas9	negative selection	1151250
47333213	47333236	3	-	26627737	RPE1	viability after 9 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	0.9612842874930676	[121]	[100,39]	6	hSpCas9	negative selection	1151251
47334759	47334782	3	-	26627737	RPE1	viability after 9 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	1.0670502920786045	[1385]	[778,1076]	6	hSpCas9	negative selection	1151252
47283047	47283070	3	+	26627737	RPE1	viability after 12 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	0.467485697522551	[1019]	[307,453]	3	hSpCas9	negative selection	1233562
47319730	47319753	3	+	26627737	RPE1	viability after 12 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.0562448068372553	[1453]	[411,399]	0	hSpCas9	negative selection	1233563
47322687	47322710	3	+	26627737	RPE1	viability after 12 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	1.8961114116731377	[0]	[0,0]	8	hSpCas9	negative selection	1233564
47330089	47330112	3	+	26627737	RPE1	viability after 12 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.9548852500599988	[1281]	[64,296]	-6	hSpCas9	negative selection	1233565
47333213	47333236	3	-	26627737	RPE1	viability after 12 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	0.8466191630517699	[121]	[73,42]	5	hSpCas9	negative selection	1233566
47334759	47334782	3	-	26627737	RPE1	viability after 12 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.6436376510988288	[1385]	[674,482]	4	hSpCas9	negative selection	1233567
47283047	47283070	3	+	26627737	RPE1	viability after 15 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	-0.13011571044371217	[1019]	[226,298]	-1	hSpCas9	negative selection	1315877
47319730	47319753	3	+	26627737	RPE1	viability after 15 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.031247135857682462	[1453]	[430,409]	0	hSpCas9	negative selection	1315878
47322687	47322710	3	+	26627737	RPE1	viability after 15 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	1.8217488738718943	[0]	[0,0]	8	hSpCas9	negative selection	1315879
47330089	47330112	3	+	26627737	RPE1	viability after 15 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-1.2552129684342697	[1281]	[127,174]	-7	hSpCas9	negative selection	1315880
47333213	47333236	3	-	26627737	RPE1	viability after 15 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	1.5907606242630634	[121]	[162,46]	8	hSpCas9	negative selection	1315881
47334759	47334782	3	-	26627737	RPE1	viability after 15 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.8039488314520916	[1385]	[599,765]	5	hSpCas9	negative selection	1315882
47283047	47283070	3	+	26627737	RPE1	viability after 18 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	-0.021905515200960513	[1019]	[259,282]	0	hSpCas9	negative selection	1398192
47319730	47319753	3	+	26627737	RPE1	viability after 18 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.17231605183026255	[1453]	[519,358]	1	hSpCas9	negative selection	1398193
47322687	47322710	3	+	26627737	RPE1	viability after 18 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	1.889668260100743	[0]	[0,0]	8	hSpCas9	negative selection	1398194
47330089	47330112	3	+	26627737	RPE1	viability after 18 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.87581955311625	[1281]	[72,311]	-5	hSpCas9	negative selection	1398195
47333213	47333236	3	-	26627737	RPE1	viability after 18 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	1.5767769857012228	[121]	[118,75]	8	hSpCas9	negative selection	1398196
47334759	47334782	3	-	26627737	RPE1	viability after 18 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.8768642166891539	[1385]	[624,752]	5	hSpCas9	negative selection	1398197
47283047	47283070	3	+	26627737	HeLa	viability after 8 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	-0.6383860025832091	[458]	[192,104,102]	-6	hSpCas9	negative selection	1480507
47319730	47319753	3	+	26627737	HeLa	viability after 8 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	-1.0930095221804692	[891]	[266,32,258]	-8	hSpCas9	negative selection	1480508
47322687	47322710	3	+	26627737	HeLa	viability after 8 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	1.200473099817617	[0]	[0,0,0]	8	hSpCas9	negative selection	1480509
47330089	47330112	3	+	26627737	HeLa	viability after 8 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.27079839883454293	[748]	[283,370,165]	-3	hSpCas9	negative selection	1480510
47333213	47333236	3	-	26627737	HeLa	viability after 8 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	1.674547975719581	[95]	[138,183,81]	9	hSpCas9	negative selection	1480511
47334759	47334782	3	-	26627737	HeLa	viability after 8 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	2.2436901663798077	[195]	[710,99,463]	9	hSpCas9	negative selection	1480512
47283047	47283070	3	+	26627737	HeLa	viability after 12 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	0.4123916965992322	[458]	[224,153,387]	3	hSpCas9	negative selection	1562822
47319730	47319753	3	+	26627737	HeLa	viability after 12 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	-0.7895505511260499	[891]	[201,160,281]	-6	hSpCas9	negative selection	1562823
47322687	47322710	3	+	26627737	HeLa	viability after 12 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	1.2748581272013126	[0]	[0,0,0]	8	hSpCas9	negative selection	1562824
47330089	47330112	3	+	26627737	HeLa	viability after 12 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.40402839340496277	[748]	[257,247,194]	-4	hSpCas9	negative selection	1562825
47333213	47333236	3	-	26627737	HeLa	viability after 12 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	1.3317419849868686	[95]	[34,96,165]	8	hSpCas9	negative selection	1562826
47334759	47334782	3	-	26627737	HeLa	viability after 12 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	2.2556684648667016	[195]	[708,186,294]	9	hSpCas9	negative selection	1562827
47283047	47283070	3	+	26627737	HeLa	viability after 15 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	0.02684522643884707	[458]	[79,211,287]	0	hSpCas9	negative selection	1645137
47319730	47319753	3	+	26627737	HeLa	viability after 15 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	-0.7171245647706257	[891]	[233,213,213]	-6	hSpCas9	negative selection	1645138
47322687	47322710	3	+	26627737	HeLa	viability after 15 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	1.2965331123080048	[0]	[0,0,0]	8	hSpCas9	negative selection	1645139
47330089	47330112	3	+	26627737	HeLa	viability after 15 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.0016222609164409096	[748]	[336,347,221]	0	hSpCas9	negative selection	1645140
47333213	47333236	3	-	26627737	HeLa	viability after 15 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	1.9419633657370625	[95]	[158,181,105]	9	hSpCas9	negative selection	1645141
47334759	47334782	3	-	26627737	HeLa	viability after 15 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	2.477445757523269	[195]	[373,213,770]	9	hSpCas9	negative selection	1645142
47283047	47283070	3	+	26627737	HeLa	viability after 18 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	0.00046096563605063645	[458]	[52,167,287]	0	hSpCas9	negative selection	1727452
47319730	47319753	3	+	26627737	HeLa	viability after 18 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	-0.6616769155685626	[891]	[169,181,213]	-5	hSpCas9	negative selection	1727453
47322687	47322710	3	+	26627737	HeLa	viability after 18 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	1.6067387639618715	[0]	[0,0,0]	9	hSpCas9	negative selection	1727454
47330089	47330112	3	+	26627737	HeLa	viability after 18 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.020036971832031902	[748]	[227,296,221]	0	hSpCas9	negative selection	1727455
47333213	47333236	3	-	26627737	HeLa	viability after 18 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	1.9730183258391092	[95]	[107,156,105]	9	hSpCas9	negative selection	1727456
47334759	47334782	3	-	26627737	HeLa	viability after 18 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	2.4705864606085566	[195]	[242,181,770]	9	hSpCas9	negative selection	1727457
47283047	47283070	3	+	26627737	HCT116	viability after 6 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	0.06664764313100918	[570]	[171,50]	0	hSpCas9	negative selection	1809767
47319730	47319753	3	+	26627737	HCT116	viability after 6 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.3740912297812877	[701]	[240,88]	2	hSpCas9	negative selection	1809768
47322687	47322710	3	+	26627737	HCT116	viability after 6 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	2.6692602571875668	[0]	[0,0]	9	hSpCas9	negative selection	1809769
47330089	47330112	3	+	26627737	HCT116	viability after 6 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.6841999141411205	[982]	[130,312]	4	hSpCas9	negative selection	1809770
47333213	47333236	3	-	26627737	HCT116	viability after 6 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	0.7335697011266433	[316]	[107,68]	4	hSpCas9	negative selection	1809771
47334759	47334782	3	-	26627737	HCT116	viability after 6 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.5057603994034658	[1700]	[253,448]	3	hSpCas9	negative selection	1809772
47283047	47283070	3	+	26627737	HCT116	viability after 8 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	0.9468323760504179	[171]	[170,121,253]	8	hSpCas9	negative selection	1892082
47319730	47319753	3	+	26627737	HCT116	viability after 8 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.9135509669141499	[339]	[503,252,304]	8	hSpCas9	negative selection	1892083
47322687	47322710	3	+	26627737	HCT116	viability after 8 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.8598070938499998	[0]	[0,0,0]	7	hSpCas9	negative selection	1892084
47330089	47330112	3	+	26627737	HCT116	viability after 8 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.5693096154303534	[530]	[278,113,199]	-6	hSpCas9	negative selection	1892085
47333213	47333236	3	-	26627737	HCT116	viability after 8 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	1.3820405894839733	[82]	[50,153,150]	9	hSpCas9	negative selection	1892086
47334759	47334782	3	-	26627737	HCT116	viability after 8 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	-0.1967802244114476	[809]	[388,450,328]	-2	hSpCas9	negative selection	1892087
47283047	47283070	3	+	26627737	HCT116	viability after 9 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	0.7655547552087251	[570]	[180,320]	5	hSpCas9	negative selection	1974397
47319730	47319753	3	+	26627737	HCT116	viability after 9 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.13698310013338094	[701]	[328,108]	1	hSpCas9	negative selection	1974398
47322687	47322710	3	+	26627737	HCT116	viability after 9 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	1.9049898113534676	[0]	[0,0]	9	hSpCas9	negative selection	1974399
47330089	47330112	3	+	26627737	HCT116	viability after 9 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.5402387720190577	[982]	[108,236]	-4	hSpCas9	negative selection	1974400
47333213	47333236	3	-	26627737	HCT116	viability after 9 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	0.059917395572721244	[316]	[85,89]	0	hSpCas9	negative selection	1974401
47334759	47334782	3	-	26627737	HCT116	viability after 9 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.15319357894115115	[1700]	[489,516]	1	hSpCas9	negative selection	1974402
47283047	47283070	3	+	26627737	HCT116	viability after 12 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	1.332496440876044	[171]	[243,207,228]	8	hSpCas9	negative selection	2056712
47319730	47319753	3	+	26627737	HCT116	viability after 12 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.9668164050047379	[339]	[302,482,268]	8	hSpCas9	negative selection	2056713
47322687	47322710	3	+	26627737	HCT116	viability after 12 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.9281650954308303	[0]	[0,0,0]	7	hSpCas9	negative selection	2056714
47330089	47330112	3	+	26627737	HCT116	viability after 12 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.09839128638071648	[530]	[278,286,214]	-1	hSpCas9	negative selection	2056715
47333213	47333236	3	-	26627737	HCT116	viability after 12 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	1.3610619165017181	[82]	[64,100,173]	9	hSpCas9	negative selection	2056716
47334759	47334782	3	-	26627737	HCT116	viability after 12 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.33650939516306755	[809]	[607,565,432]	3	hSpCas9	negative selection	2056717
47283047	47283070	3	+	26627737	HCT116	viability after 15 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	1.3588472605266344	[171]	[272,116,370]	8	hSpCas9	negative selection	2139027
47319730	47319753	3	+	26627737	HCT116	viability after 15 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.8264099919287144	[339]	[435,294,318]	7	hSpCas9	negative selection	2139028
47322687	47322710	3	+	26627737	HCT116	viability after 15 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.8001368291432343	[0]	[0,0,0]	7	hSpCas9	negative selection	2139029
47330089	47330112	3	+	26627737	HCT116	viability after 15 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.046272160801651196	[530]	[167,294,461]	0	hSpCas9	negative selection	2139030
47333213	47333236	3	-	26627737	HCT116	viability after 15 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	1.566768850031265	[82]	[147,97,177]	9	hSpCas9	negative selection	2139031
47334759	47334782	3	-	26627737	HCT116	viability after 15 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.41029595198484636	[809]	[766,676,430]	4	hSpCas9	negative selection	2139032
47283047	47283070	3	+	26627737	HCT116	viability after 18 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	1.5814573030971557	[171]	[142,202,410]	9	hSpCas9	negative selection	2221342
47319730	47319753	3	+	26627737	HCT116	viability after 18 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.9182958973365367	[339]	[356,273,302]	7	hSpCas9	negative selection	2221343
47322687	47322710	3	+	26627737	HCT116	viability after 18 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	1.0485523756554223	[0]	[0,0,0]	7	hSpCas9	negative selection	2221344
47330089	47330112	3	+	26627737	HCT116	viability after 18 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.14907872252589238	[530]	[276,201,384]	1	hSpCas9	negative selection	2221345
47333213	47333236	3	-	26627737	HCT116	viability after 18 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	1.9716852994321281	[82]	[182,113,178]	9	hSpCas9	negative selection	2221346
47334759	47334782	3	-	26627737	HCT116	viability after 18 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.8127512671241479	[809]	[855,640,563]	6	hSpCas9	negative selection	2221347
47282926	47282949	3	-	25494202	A375	resistance to PLX-4720 (puromycin)	ACTGCGCAGGCCTCGCCGGCCGG	KLHL18	ENSG00000114648	0.28026941569218194	[27,100]	[20,12]	1	dCas9-VP64	positive selection	2473949
47282950	47282973	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	GCAGCGGCCGGGGAAGATGGTGG	KLHL18	ENSG00000114648	-0.09805975681336365	[60,0]	[10,0]	0	dCas9-VP64	positive selection	2473950
47283014	47283037	3	+	25494202	A375	resistance to PLX-4720 (puromycin)	GTGTCTGAGTTGCCTAGTCGCGG	KLHL18	ENSG00000114648	1.9977456672446459	[127,72]	[77,97]	7	dCas9-VP64	positive selection	2473951
47282926	47282949	3	-	25494202	A375	resistance to PLX-4720 (zeocin)	ACTGCGCAGGCCTCGCCGGCCGG	KLHL18	ENSG00000114648	-1.120500485000551	[33,303]	[27,20]	-9	dCas9-VP64	positive selection	2569204
47282950	47282973	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	GCAGCGGCCGGGGAAGATGGTGG	KLHL18	ENSG00000114648	2.904073147038573	[14,30]	[4,105]	9	dCas9-VP64	positive selection	2569205
47283014	47283037	3	+	25494202	A375	resistance to PLX-4720 (zeocin)	GTGTCTGAGTTGCCTAGTCGCGG	KLHL18	ENSG00000114648	-0.2979600234597281	[88,150]	[38,23]	-3	dCas9-VP64	positive selection	2569206
47333256	47333279	3	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ACTCTGTCTGAAAGGAACTGGGG	KLHL18	ENSG00000114648	0.9140235231361249	[3,2]	[4,6]	9	hSpCas9	positive selection	2997779
47334759	47334782	3	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.18737043103900478	[2,2]	[1,3]	4	hSpCas9	positive selection	2997780
47322688	47322711	3	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.039646208436701684	[3,3]	[3,2]	0	hSpCas9	positive selection	2997781
47319675	47319698	3	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	-0.4914321903215555	[2,2]	[2,0]	-6	hSpCas9	positive selection	2997782
47333256	47333279	3	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ACTCTGTCTGAAAGGAACTGGGG	KLHL18	ENSG00000114648	-0.5658580213311064	[3,3]	[1,0]	-7	hSpCas9	positive selection	3065637
47334759	47334782	3	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.18472558815318765	[2,2]	[2,2]	3	hSpCas9	positive selection	3065638
47322688	47322711	3	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	1.1972679282800769	[3,3]	[3,7]	9	hSpCas9	positive selection	3065639
47319675	47319698	3	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	-0.15331449609797204	[2,2]	[1,1]	-2	hSpCas9	positive selection	3065640
47333233	47333256		+	24336571	A375	resistance to PLX after 7 days	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.19121950341730676	[21,26]	[21,20]	-6	hSpCas9	positive selection	3123406
47329958	47329981		-	24336571	A375	resistance to PLX after 7 days	CGCACACCCAGGCAGTTTTTTGG	KLHL18	ENSG00000114648	0.06555544727332041	[26,27]	[28,28]	2	hSpCas9	positive selection	3123407
47330089	47330112		+	24336571	A375	resistance to PLX after 7 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.3673686872824047	[3,2]	[1,2]	-9	hSpCas9	positive selection	3123408
47329951	47329974		+	24336571	A375	resistance to PLX after 7 days	GCTTCACCCAAAAAACTGCCTGG	KLHL18	ENSG00000114648	0.31389388645348204	[4,4]	[5,6]	8	hSpCas9	positive selection	3123409
47333182	47333205		+	24336571	A375	resistance to PLX after 7 days	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	0.3645779987437954	[4,6]	[8,6]	8	hSpCas9	positive selection	3123410
47333233	47333256		+	24336571	A375	resistance to PLX after 14 days	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.5308501486458522	[22,25]	[6,8]	-6	hSpCas9	positive selection	3181199
47329958	47329981		-	24336571	A375	resistance to PLX after 14 days	CGCACACCCAGGCAGTTTTTTGG	KLHL18	ENSG00000114648	-0.981185115366192	[40,40]	[9,7]	-9	hSpCas9	positive selection	3181200
47330089	47330112		+	24336571	A375	resistance to PLX after 14 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.8504414579803252	[2,1]	[1,1]	7	hSpCas9	positive selection	3181201
47329951	47329974		+	24336571	A375	resistance to PLX after 14 days	GCTTCACCCAAAAAACTGCCTGG	KLHL18	ENSG00000114648	0.18184041626775493	[4,8]	[2,2]	2	hSpCas9	positive selection	3181202
47333182	47333205		+	24336571	A375	resistance to PLX after 14 days	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	0.5127522705743647	[4,9]	[3,4]	5	hSpCas9	positive selection	3181203
47333233	47333256		+	24336571	A375	viability after 7 days	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.1726201157230275	[22]	[21,26]	2	hSpCas9	negative selection	3238992
47329958	47329981		-	24336571	A375	viability after 7 days	CGCACACCCAGGCAGTTTTTTGG	KLHL18	ENSG00000114648	0.3937374388862377	[21]	[26,27]	6	hSpCas9	negative selection	3238993
47330089	47330112		+	24336571	A375	viability after 7 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.4755981634462021	[1]	[3,2]	7	hSpCas9	negative selection	3238994
47329951	47329974		+	24336571	A375	viability after 7 days	GCTTCACCCAAAAAACTGCCTGG	KLHL18	ENSG00000114648	-0.45787415011330235	[7]	[4,4]	-6	hSpCas9	negative selection	3238995
47333182	47333205		+	24336571	A375	viability after 7 days	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	-0.33662233343395354	[7]	[4,6]	-5	hSpCas9	negative selection	3238996
47333233	47333256		+	24336571	A375	viability after 14 days	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.21212367907148388	[22]	[22,25]	2	hSpCas9	negative selection	3296785
47329958	47329981		-	24336571	A375	viability after 14 days	CGCACACCCAGGCAGTTTTTTGG	KLHL18	ENSG00000114648	0.949707157146325	[21]	[40,40]	9	hSpCas9	negative selection	3296786
47330089	47330112		+	24336571	A375	viability after 14 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.0746376892055447	[1]	[2,1]	-1	hSpCas9	negative selection	3296787
47329951	47329974		+	24336571	A375	viability after 14 days	GCTTCACCCAAAAAACTGCCTGG	KLHL18	ENSG00000114648	-0.16131548012988872	[7]	[4,8]	-2	hSpCas9	negative selection	3296788
47333182	47333205		+	24336571	A375	viability after 14 days	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	-0.06502260942338056	[7]	[4,9]	0	hSpCas9	negative selection	3296789
47319679	47319702	3	-	27383988	293T	resistance to West Nile virus (flavivirus)	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	0.5024387092823666	[107,107]	[0,0]	2	hSpCas9	positive selection	3375999
47333233	47333256	3	+	27383988	293T	resistance to West Nile virus (flavivirus)	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.14880175466766601	[137,137]	[0,0]	0	hSpCas9	positive selection	3376000
47333217	47333240	3	-	27383988	293T	resistance to West Nile virus (flavivirus)	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	0.47596649792117546	[109,109]	[0,0]	2	hSpCas9	positive selection	3376001
47333256	47333279	3	-	26780180	HT29	viability (Avana library 4 designs)	ACTCTGTCTGAAAGGAACTGGGG	KLHL18	ENSG00000114648	1.1447513132051	[]	[]	4	hSpCas9	negative selection	3435219
47334759	47334782	3	-	26780180	HT29	viability (Avana library 4 designs)	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.84380323659639	[]	[]	3	hSpCas9	negative selection	3435220
47322687	47322710	3	+	26780180	HT29	viability (Avana library 4 designs)	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.298142370907661	[]	[]	1	hSpCas9	negative selection	3435221
47319675	47319698	3	-	26780180	HT29	viability (Avana library 4 designs)	GGCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	1.49734706912022	[]	[]	6	hSpCas9	negative selection	3435222
47319675	47319698	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	3.59755310313125	[]	[]	6	hSpCas9	negative selection	3522688
47333256	47333279	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	ACTCTGTCTGAAAGGAACTGGGG	KLHL18	ENSG00000114648	3.12099355336456	[]	[]	5	hSpCas9	negative selection	3522689
47334759	47334782	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	4.40818321679679	[]	[]	7	hSpCas9	negative selection	3522690
47322687	47322710	3	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	-4.05885628272914	[]	[]	-5	hSpCas9	negative selection	3522691
47319676	47319699	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	-0.0295801484576489	[]	[]	0	hSpCas9	negative selection	3522692
47330087	47330110	3	-	26780180	A375	viability (Avana lentiCRISPRv2)	AGCTCAAGCACGTCTTCCAAGGG	KLHL18	ENSG00000114648	-1.6822317418568	[]	[]	-2	hSpCas9	negative selection	3522693
47319675	47319698	3	-	26780180	A375	viability (Avana lentiGuide)	GGCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	8.47881650814684	[]	[]	6	hSpCas9	negative selection	3631347
47333256	47333279	3	-	26780180	A375	viability (Avana lentiGuide)	ACTCTGTCTGAAAGGAACTGGGG	KLHL18	ENSG00000114648	2.15083874847278	[]	[]	2	hSpCas9	negative selection	3631348
47334759	47334782	3	-	26780180	A375	viability (Avana lentiGuide)	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	-5.7774463668863	[]	[]	-8	hSpCas9	negative selection	3631349
47322687	47322710	3	+	26780180	A375	viability (Avana lentiGuide)	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	2.19093741964746	[]	[]	2	hSpCas9	negative selection	3631350
47319676	47319699	3	-	26780180	A375	viability (Avana lentiGuide)	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	5.50355552300816	[]	[]	5	hSpCas9	negative selection	3631351
47330087	47330110	3	-	26780180	A375	viability (Avana lentiGuide)	AGCTCAAGCACGTCTTCCAAGGG	KLHL18	ENSG00000114648	0.676807864959721	[]	[]	0	hSpCas9	negative selection	3631352
47319675	47319698	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	0.12738537633667907	[4]	[4,3]	3	hSpCas9	positive selection	3740006
47333256	47333279	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ACTCTGTCTGAAAGGAACTGGGG	KLHL18	ENSG00000114648	-0.2503208966746768	[4]	[5,2]	-4	hSpCas9	positive selection	3740007
47334759	47334782	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.22165018006124965	[3]	[3,4]	6	hSpCas9	positive selection	3740008
47322687	47322710	3	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	-0.1508707725252547	[4]	[4,3]	-2	hSpCas9	positive selection	3740009
47319676	47319699	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	0.03276667789223822	[5]	[5,5]	0	hSpCas9	positive selection	3740010
47330087	47330110	3	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AGCTCAAGCACGTCTTCCAAGGG	KLHL18	ENSG00000114648	-0.15765277405017852	[6]	[4,5]	-3	hSpCas9	positive selection	3740011
47319675	47319698	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	-0.5587290118051065	[5]	[4,1]	-6	hSpCas9	positive selection	3848613
47333256	47333279	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ACTCTGTCTGAAAGGAACTGGGG	KLHL18	ENSG00000114648	-0.1922270450656438	[4]	[4,2]	-3	hSpCas9	positive selection	3848614
47334759	47334782	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	-0.2804499944011373	[4]	[3,2]	-4	hSpCas9	positive selection	3848615
47322687	47322710	3	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.04218266247894728	[4]	[4,3]	0	hSpCas9	positive selection	3848616
47319676	47319699	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	0.034560631980798756	[6]	[5,5]	0	hSpCas9	positive selection	3848617
47330087	47330110	3	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AGCTCAAGCACGTCTTCCAAGGG	KLHL18	ENSG00000114648	-0.016002799998025535	[6]	[6,4]	0	hSpCas9	positive selection	3848618
47333233	47333256	3	+	26780180	A375	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	1.20700679201619	[]	[]	6	hSpCas9	negative selection	3954659
47322697	47322720	3	-	26780180	A375	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.540546537182275	[]	[]	1	hSpCas9	negative selection	3954660
47333217	47333240	3	-	26780180	A375	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	1.1633931675715	[]	[]	6	hSpCas9	negative selection	3954661
47330089	47330112	3	+	26780180	A375	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.53919325313001	[]	[]	1	hSpCas9	negative selection	3954662
47322687	47322710	3	+	26780180	A375	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.51658410842419	[]	[]	1	hSpCas9	negative selection	3954663
47319679	47319702	3	-	26780180	A375	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	1.76783085954695	[]	[]	9	hSpCas9	negative selection	3954664
47333233	47333256	3	+	26780180	HT29	viability (GeCKOv2 library)	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	1.46269451511686	[]	[]	7	hSpCas9	negative selection	4062625
47322697	47322720	3	-	26780180	HT29	viability (GeCKOv2 library)	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	1.16755926599807	[]	[]	5	hSpCas9	negative selection	4062626
47333217	47333240	3	-	26780180	HT29	viability (GeCKOv2 library)	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	1.00818920709127	[]	[]	4	hSpCas9	negative selection	4062627
47330089	47330112	3	+	26780180	HT29	viability (GeCKOv2 library)	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.689967538201828	[]	[]	2	hSpCas9	negative selection	4062628
47322687	47322710	3	+	26780180	HT29	viability (GeCKOv2 library)	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.143551115329669	[]	[]	0	hSpCas9	negative selection	4062629
47319679	47319702	3	-	26780180	HT29	viability (GeCKOv2 library)	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	1.43870327536893	[]	[]	7	hSpCas9	negative selection	4062630
47333233	47333256	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.1409566178518999	[4]	[3,2]	3	hSpCas9	positive selection	4147342
47329958	47329981	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CGCACACCCAGGCAGTTTTTTGG	KLHL18	ENSG00000114648	0.0393617113652025	[4]	[3,3]	1	hSpCas9	positive selection	4147343
47330089	47330112	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.19905558985314253	[0]	[0,0]	-5	hSpCas9	positive selection	4147344
47329951	47329974	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCTTCACCCAAAAAACTGCCTGG	KLHL18	ENSG00000114648	-0.15357443928937908	[2]	[1,1]	-4	hSpCas9	positive selection	4147345
47333182	47333205	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	0.15471746408821005	[3]	[2,2]	4	hSpCas9	positive selection	4147346
47333233	47333256	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.8203683851662036	[4]	[3,4,4,2]	5	hSpCas9	positive selection	4211364
47329958	47329981	3	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CGCACACCCAGGCAGTTTTTTGG	KLHL18	ENSG00000114648	0.46415645421884144	[3]	[3,5,1,0]	3	hSpCas9	positive selection	4211365
47330089	47330112	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.16963431075511196	[3]	[0,4,1,0]	1	hSpCas9	positive selection	4211366
47329951	47329974	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCTTCACCCAAAAAACTGCCTGG	KLHL18	ENSG00000114648	-0.2850305629919247	[3]	[1,2,0,0]	-4	hSpCas9	positive selection	4211367
47333182	47333205	3	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	-0.1851245438028108	[2]	[0,0,1,0]	-3	hSpCas9	positive selection	4211368
47322687	47322710	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.26352400958497857	[1]	[2,1]	5	hSpCas9	positive selection	4278819
47322697	47322720	3	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.3171187651816585	[2]	[3,1]	6	hSpCas9	positive selection	4278820
47330089	47330112	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.15373901633258447	[0]	[1,0]	3	hSpCas9	positive selection	4278821
47319679	47319702	3	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.034624511279687326	[2]	[3,1]	0	hSpCas9	positive selection	4343075
47333233	47333256	3	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.050419095597446784	[3]	[3,1]	1	hSpCas9	positive selection	4343076
47333217	47333240	3	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	0.2654621299905206	[2]	[2,2]	5	hSpCas9	positive selection	4343077
47319675	47319697	3	-	27760321	OCIAML3	viability	GCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	-0.12608700678810303	[283,242]	[179,198]	-1	hSpCas9	negative selection	4412621
47322693	47322715	3	+	27760321	OCIAML3	viability	CATTCCTTCGAGAACGGTGAGG	KLHL18	ENSG00000114648	-0.11429266285918172	[587,555]	[381,454]	-1	hSpCas9	negative selection	4412622
47333176	47333198	3	-	27760321	OCIAML3	viability	TCCCGGTCGTATCTGACCCAGG	KLHL18	ENSG00000114648	-0.43130894843721956	[599,507]	[294,352]	-4	hSpCas9	negative selection	4412623
47333291	47333313	3	-	27760321	OCIAML3	viability	TTTGTGGCAGCAACGCACCAGG	KLHL18	ENSG00000114648	-0.02981874458343267	[533,406]	[318,407]	0	hSpCas9	negative selection	4412624
47334775	47334797	3	-	27760321	OCIAML3	viability	GCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-0.22597647085969788	[675,540]	[328,502]	-2	hSpCas9	negative selection	4412625
47319675	47319697	3	-	27760321	OCIAML2	viability	GCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	-0.0035709359094748816	[283,242]	[173,261]	0	hSpCas9	negative selection	4496084
47322693	47322715	3	+	27760321	OCIAML2	viability	CATTCCTTCGAGAACGGTGAGG	KLHL18	ENSG00000114648	0.21666637559762647	[587,555]	[419,693]	3	hSpCas9	negative selection	4496085
47333176	47333198	3	-	27760321	OCIAML2	viability	TCCCGGTCGTATCTGACCCAGG	KLHL18	ENSG00000114648	-0.28016495285118215	[599,507]	[277,485]	-3	hSpCas9	negative selection	4496086
47333291	47333313	3	-	27760321	OCIAML2	viability	TTTGTGGCAGCAACGCACCAGG	KLHL18	ENSG00000114648	-0.07643913608665516	[533,406]	[292,443]	-1	hSpCas9	negative selection	4496087
47334775	47334797	3	-	27760321	OCIAML2	viability	GCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-0.19129972122413513	[675,540]	[359,518]	-2	hSpCas9	negative selection	4496088
47319675	47319697	3	-	27760321	MV411	viability	GCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	0.3696112165288015	[283,242]	[177,292]	2	hSpCas9	negative selection	4579547
47322693	47322715	3	+	27760321	MV411	viability	CATTCCTTCGAGAACGGTGAGG	KLHL18	ENSG00000114648	0.4645826973060465	[587,555]	[500,551]	3	hSpCas9	negative selection	4579548
47333176	47333198	3	-	27760321	MV411	viability	TCCCGGTCGTATCTGACCCAGG	KLHL18	ENSG00000114648	0.20413519068475722	[599,507]	[497,301]	1	hSpCas9	negative selection	4579549
47333291	47333313	3	-	27760321	MV411	viability	TTTGTGGCAGCAACGCACCAGG	KLHL18	ENSG00000114648	-0.9858122394134062	[533,406]	[99,238]	-6	hSpCas9	negative selection	4579550
47334775	47334797	3	-	27760321	MV411	viability	GCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-0.48327475497972794	[675,540]	[257,326]	-3	hSpCas9	negative selection	4579551
47319675	47319697	3	-	27760321	HL60	viability	GCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	0.5258017850054105	[283,242]	[339,275]	6	hSpCas9	negative selection	4663010
47322693	47322715	3	+	27760321	HL60	viability	CATTCCTTCGAGAACGGTGAGG	KLHL18	ENSG00000114648	0.06201661903171507	[587,555]	[529,443]	0	hSpCas9	negative selection	4663011
47333176	47333198	3	-	27760321	HL60	viability	TCCCGGTCGTATCTGACCCAGG	KLHL18	ENSG00000114648	-0.38174757985197494	[599,507]	[415,271]	-4	hSpCas9	negative selection	4663012
47333291	47333313	3	-	27760321	HL60	viability	TTTGTGGCAGCAACGCACCAGG	KLHL18	ENSG00000114648	0.03815433478848096	[533,406]	[343,441]	0	hSpCas9	negative selection	4663013
47334775	47334797	3	-	27760321	HL60	viability	GCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-0.15202050126063588	[675,540]	[419,470]	-2	hSpCas9	negative selection	4663014
47319675	47319697	3	-	27760321	HT1080	viability	GCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	0.43592317895181865	[242,189]	[88,146]	2	hSpCas9	negative selection	4746473
47322693	47322715	3	+	27760321	HT1080	viability	CATTCCTTCGAGAACGGTGAGG	KLHL18	ENSG00000114648	-0.09201750031217498	[555,433]	[258,103]	0	hSpCas9	negative selection	4746474
47333176	47333198	3	-	27760321	HT1080	viability	TCCCGGTCGTATCTGACCCAGG	KLHL18	ENSG00000114648	0.6951985804485146	[507,396]	[278,305]	4	hSpCas9	negative selection	4746475
47333291	47333313	3	-	27760321	HT1080	viability	TTTGTGGCAGCAACGCACCAGG	KLHL18	ENSG00000114648	0.2874247714036373	[406,317]	[265,77]	1	hSpCas9	negative selection	4746476
47334775	47334797	3	-	27760321	HT1080	viability	GCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-1.0583259121809978	[540,421]	[9,181]	-4	hSpCas9	negative selection	4746477
47319675	47319697	3	-	27760321	HT29	viability after 7 days	GCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	0.35835339601064564	[242,189]	[318,460,286]	5	hSpCas9	negative selection	4829936
47322693	47322715	3	+	27760321	HT29	viability after 7 days	CATTCCTTCGAGAACGGTGAGG	KLHL18	ENSG00000114648	0.10123700104812644	[555,433]	[556,751,718]	1	hSpCas9	negative selection	4829937
47333176	47333198	3	-	27760321	HT29	viability after 7 days	TCCCGGTCGTATCTGACCCAGG	KLHL18	ENSG00000114648	0.025322553214370602	[507,396]	[662,636,488]	0	hSpCas9	negative selection	4829938
47333291	47333313	3	-	27760321	HT29	viability after 7 days	TTTGTGGCAGCAACGCACCAGG	KLHL18	ENSG00000114648	0.029428719746735325	[406,317]	[544,500,392]	0	hSpCas9	negative selection	4829939
47334775	47334797	3	-	27760321	HT29	viability after 7 days	GCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-0.09325864788333066	[540,421]	[819,302,648]	-1	hSpCas9	negative selection	4829940
47319675	47319697	3	-	27760321	HT29	viability after 25 days	GCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	0.2568453042803638	[242,189]	[333,203,351]	2	hSpCas9	negative selection	4913399
47322693	47322715	3	+	27760321	HT29	viability after 25 days	CATTCCTTCGAGAACGGTGAGG	KLHL18	ENSG00000114648	-0.05614615605385603	[555,433]	[562,456,617]	0	hSpCas9	negative selection	4913400
47333176	47333198	3	-	27760321	HT29	viability after 25 days	TCCCGGTCGTATCTGACCCAGG	KLHL18	ENSG00000114648	0.027811818176689318	[507,396]	[363,580,659]	0	hSpCas9	negative selection	4913401
47333291	47333313	3	-	27760321	HT29	viability after 25 days	TTTGTGGCAGCAACGCACCAGG	KLHL18	ENSG00000114648	0.1077985696567188	[406,317]	[285,665,390]	1	hSpCas9	negative selection	4913402
47334775	47334797	3	-	27760321	HT29	viability after 25 days	GCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	0.17247976361424078	[540,421]	[645,615,592]	1	hSpCas9	negative selection	4913403
47319675	47319697	3	-	27760321	HT29	viability after 22 days	GCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	0.11364271987291863	[242,189]	[347,231,229]	1	hSpCas9	negative selection	4996862
47322693	47322715	3	+	27760321	HT29	viability after 22 days	CATTCCTTCGAGAACGGTGAGG	KLHL18	ENSG00000114648	0.2135535199927206	[555,433]	[896,559,525]	2	hSpCas9	negative selection	4996863
47333176	47333198	3	-	27760321	HT29	viability after 22 days	TCCCGGTCGTATCTGACCCAGG	KLHL18	ENSG00000114648	0.1838897193182732	[507,396]	[635,516,628]	1	hSpCas9	negative selection	4996864
47333291	47333313	3	-	27760321	HT29	viability after 22 days	TTTGTGGCAGCAACGCACCAGG	KLHL18	ENSG00000114648	0.23251171309451796	[406,317]	[610,572,287]	2	hSpCas9	negative selection	4996865
47334775	47334797	3	-	27760321	HT29	viability after 22 days	GCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	0.5187150944886039	[540,421]	[1258,726,389]	6	hSpCas9	negative selection	4996866
47319675	47319697	3	-	27760321	HT29	viability after 19 days	GCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	0.15122896314962286	[242,189]	[182,378,253]	1	hSpCas9	negative selection	5080325
47322693	47322715	3	+	27760321	HT29	viability after 19 days	CATTCCTTCGAGAACGGTGAGG	KLHL18	ENSG00000114648	-0.28251363036982297	[555,433]	[609,438,365]	-3	hSpCas9	negative selection	5080326
47333176	47333198	3	-	27760321	HT29	viability after 19 days	TCCCGGTCGTATCTGACCCAGG	KLHL18	ENSG00000114648	0.14902819664718975	[507,396]	[511,527,670]	1	hSpCas9	negative selection	5080327
47333291	47333313	3	-	27760321	HT29	viability after 19 days	TTTGTGGCAGCAACGCACCAGG	KLHL18	ENSG00000114648	0.2676956922090382	[406,317]	[680,546,295]	2	hSpCas9	negative selection	5080328
47334775	47334797	3	-	27760321	HT29	viability after 19 days	GCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-0.22888588358011686	[540,421]	[843,255,352]	-2	hSpCas9	negative selection	5080329
47319675	47319697	3	-	27760321	HT29	viability after 16 days	GCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	0.49861087481477234	[242,189]	[271,498,244]	6	hSpCas9	negative selection	5163788
47322693	47322715	3	+	27760321	HT29	viability after 16 days	CATTCCTTCGAGAACGGTGAGG	KLHL18	ENSG00000114648	-0.6603146334285831	[555,433]	[261,382,396]	-6	hSpCas9	negative selection	5163789
47333176	47333198	3	-	27760321	HT29	viability after 16 days	TCCCGGTCGTATCTGACCCAGG	KLHL18	ENSG00000114648	0.07870009892914942	[507,396]	[487,517,593]	0	hSpCas9	negative selection	5163790
47333291	47333313	3	-	27760321	HT29	viability after 16 days	TTTGTGGCAGCAACGCACCAGG	KLHL18	ENSG00000114648	0.04502088718424409	[406,317]	[347,365,535]	0	hSpCas9	negative selection	5163791
47334775	47334797	3	-	27760321	HT29	viability after 16 days	GCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-0.43985168734985924	[540,421]	[478,283,438]	-4	hSpCas9	negative selection	5163792
47319675	47319697	3	-	27760321	HT29	viability after 13 days	GCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	0.45617805485828455	[242,189]	[601,151,282]	6	hSpCas9	negative selection	5247251
47322693	47322715	3	+	27760321	HT29	viability after 13 days	CATTCCTTCGAGAACGGTGAGG	KLHL18	ENSG00000114648	-0.3954171973324927	[555,433]	[501,429,380]	-5	hSpCas9	negative selection	5247252
47333176	47333198	3	-	27760321	HT29	viability after 13 days	TCCCGGTCGTATCTGACCCAGG	KLHL18	ENSG00000114648	-0.21211772917021265	[507,396]	[426,400,526]	-2	hSpCas9	negative selection	5247253
47333291	47333313	3	-	27760321	HT29	viability after 13 days	TTTGTGGCAGCAACGCACCAGG	KLHL18	ENSG00000114648	0.029050792888835907	[406,317]	[520,420,349]	0	hSpCas9	negative selection	5247254
47334775	47334797	3	-	27760321	HT29	viability after 13 days	GCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-0.1587655003742987	[540,421]	[604,552,351]	-2	hSpCas9	negative selection	5247255
47319675	47319697	3	-	27760321	HT29	viability after 10 days	GCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	-0.4433593028425411	[242,189]	[188,234,173]	-5	hSpCas9	negative selection	5330714
47322693	47322715	3	+	27760321	HT29	viability after 10 days	CATTCCTTCGAGAACGGTGAGG	KLHL18	ENSG00000114648	-0.22425921264172724	[555,433]	[615,447,520]	-3	hSpCas9	negative selection	5330715
47333176	47333198	3	-	27760321	HT29	viability after 10 days	TCCCGGTCGTATCTGACCCAGG	KLHL18	ENSG00000114648	0.4347897103262324	[507,396]	[586,920,786]	6	hSpCas9	negative selection	5330716
47333291	47333313	3	-	27760321	HT29	viability after 10 days	TTTGTGGCAGCAACGCACCAGG	KLHL18	ENSG00000114648	0.25129879998385785	[406,317]	[429,723,468]	3	hSpCas9	negative selection	5330717
47334775	47334797	3	-	27760321	HT29	viability after 10 days	GCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-0.010295679080208786	[540,421]	[644,443,694]	0	hSpCas9	negative selection	5330718
47319675	47319697	3	-	27760321	MOLM13	viability	GCTGCTAAGACAATCCGGTGGG	KLHL18	ENSG00000114648	-0.4665668562089281	[283,242]	[197,29]	-3	hSpCas9	negative selection	5414177
47322693	47322715	3	+	27760321	MOLM13	viability	CATTCCTTCGAGAACGGTGAGG	KLHL18	ENSG00000114648	-0.7044345472217874	[587,555]	[120,263]	-4	hSpCas9	negative selection	5414178
47333176	47333198	3	-	27760321	MOLM13	viability	TCCCGGTCGTATCTGACCCAGG	KLHL18	ENSG00000114648	-0.4443692098258486	[599,507]	[384,95]	-3	hSpCas9	negative selection	5414179
47333291	47333313	3	-	27760321	MOLM13	viability	TTTGTGGCAGCAACGCACCAGG	KLHL18	ENSG00000114648	0.1348414882307458	[533,406]	[326,256]	0	hSpCas9	negative selection	5414180
47334775	47334797	3	-	27760321	MOLM13	viability	GCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	0.06569378350245197	[675,540]	[508,227]	0	hSpCas9	negative selection	5414181
47283134	47283157	3	+	27661255	K562	viability	GTCGAGCGGGGAGTAAAAAGGGG	KLHL18	ENSG00000114648	-0.1667112215115526	[678,583]	[509,399]	-5	dCas9-KRAB	negative selection	5488913
47283322	47283345	3	+	27661255	K562	viability	GCCGCTTAGGCCCTTGGAGTGGG	KLHL18	ENSG00000114648	0.6552878277765171	[73,206]	[183,164]	9	dCas9-KRAB	negative selection	5488914
47283331	47283354	3	+	27661255	K562	viability	GCCCTTGGAGTGGGAGACACGGG	KLHL18	ENSG00000114648	1.4540586584085498	[0,56]	[50,69]	9	dCas9-KRAB	negative selection	5488915
47282909	47282932	3	-	27661255	K562	viability	GGCCGGCTAGACACTAACCAGGG	KLHL18	ENSG00000114648	-0.003692430612552422	[1112,1343]	[1103,865]	0	dCas9-KRAB	negative selection	5488916
47283360	47283383	3	-	27661255	K562	viability	GTCTGCATGACAGAAAAAGGAGG	KLHL18	ENSG00000114648	-0.11530053352882114	[1027,1066]	[819,730]	-4	dCas9-KRAB	negative selection	5488917
47322687	47322710	3	+	27260156	BXPC3	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.49372813701026874	[193]	[210,280,285,382]	9	hSpCas9	negative selection	5551279
47322697	47322720	3	-	27260156	BXPC3	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.37987662671709915	[374]	[445,494,509,605]	7	hSpCas9	negative selection	5551280
47330089	47330112	3	+	27260156	BXPC3	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.6181123895209142	[46]	[27,107,82,86]	9	hSpCas9	negative selection	5551281
47319679	47319702	3	-	27260156	BXPC3	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.16706509266942401	[410]	[299,378,495,361]	-4	hSpCas9	negative selection	5615535
47333233	47333256	3	+	27260156	BXPC3	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.06342807690844654	[536]	[615,537,614,571]	1	hSpCas9	negative selection	5615536
47333217	47333240	3	-	27260156	BXPC3	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.05397983900278486	[344]	[338,284,309,472]	-1	hSpCas9	negative selection	5615537
47322687	47322710	3	+	27260156	A673	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.3001117186951522	[193]	[348,195,219,397]	7	hSpCas9	negative selection	5672530
47322697	47322720	3	-	27260156	A673	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.44554021458802956	[374]	[583,682,606,569]	8	hSpCas9	negative selection	5672531
47330089	47330112	3	+	27260156	A673	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.23219058132915116	[46]	[53,85,73,47]	5	hSpCas9	negative selection	5672532
47319679	47319702	3	-	27260156	A673	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.1848357431545675	[410]	[469,411,344,518]	-4	hSpCas9	negative selection	5736786
47333233	47333256	3	+	27260156	A673	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.2448861074456108	[536]	[760,704,772,819]	6	hSpCas9	negative selection	5736787
47333217	47333240	3	-	27260156	A673	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.1351687999819577	[344]	[411,375,410,308]	-3	hSpCas9	negative selection	5736788
47322687	47322710	3	+	27260156	A375	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.7036500818321659	[193]	[298,289,521,353]	9	hSpCas9	negative selection	5793781
47322697	47322720	3	-	27260156	A375	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.1387943291627527	[374]	[529,455,494,446]	2	hSpCas9	negative selection	5793782
47330089	47330112	3	+	27260156	A375	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.24218831284239428	[46]	[72,50,53,77]	3	hSpCas9	negative selection	5793783
47319679	47319702	3	-	27260156	A375	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	0.0555502710950167	[410]	[552,444,641,362]	0	hSpCas9	negative selection	5858037
47333233	47333256	3	+	27260156	A375	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.04725040381885895	[536]	[755,509,611,542]	0	hSpCas9	negative selection	5858038
47333217	47333240	3	-	27260156	A375	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.1035366659236941	[344]	[338,629,282,291]	-1	hSpCas9	negative selection	5858039
47322687	47322710	3	+	27260156	COLO741	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.6617311114743666	[193]	[446,367,366]	9	hSpCas9	negative selection	5915032
47322697	47322720	3	-	27260156	COLO741	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.574291772833559	[374]	[649,861,627]	9	hSpCas9	negative selection	5915033
47330089	47330112	3	+	27260156	COLO741	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.14680167855769044	[46]	[30,51,75]	-3	hSpCas9	negative selection	5915034
47319679	47319702	3	-	27260156	COLO741	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	0.04372791625416578	[410]	[488,610,519]	0	hSpCas9	negative selection	5979288
47333233	47333256	3	+	27260156	COLO741	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.19610356916655103	[536]	[774,477,559]	-4	hSpCas9	negative selection	5979289
47333217	47333240	3	-	27260156	COLO741	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.4896089740455079	[344]	[354,267,320]	-8	hSpCas9	negative selection	5979290
47322687	47322710	3	+	27260156	CAL120	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.8856690200082089	[193]	[711,390,277]	9	hSpCas9	negative selection	6036283
47322697	47322720	3	-	27260156	CAL120	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.29808683203182906	[374]	[747,580,420]	4	hSpCas9	negative selection	6036284
47330089	47330112	3	+	27260156	CAL120	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-1.2482395160190154	[46]	[11,37,21]	-9	hSpCas9	negative selection	6036285
47319679	47319702	3	-	27260156	CAL120	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.2592906216963723	[410]	[505,438,349]	-4	hSpCas9	negative selection	6100539
47333233	47333256	3	+	27260156	CAL120	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.6967061884306489	[536]	[418,478,340]	-7	hSpCas9	negative selection	6100540
47333217	47333240	3	-	27260156	CAL120	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-1.1546335632824933	[344]	[224,149,207]	-9	hSpCas9	negative selection	6100541
47322687	47322710	3	+	27260156	CADOES1	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	1.0126854105316718	[193]	[420,393,305,333]	9	hSpCas9	negative selection	6157534
47322697	47322720	3	-	27260156	CADOES1	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.33867224083562897	[374]	[434,695,289,339]	5	hSpCas9	negative selection	6157535
47330089	47330112	3	+	27260156	CADOES1	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.5833362107454296	[46]	[75,50,41,93]	8	hSpCas9	negative selection	6157536
47319679	47319702	3	-	27260156	CADOES1	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.37676742208805825	[410]	[284,281,330,278]	-6	hSpCas9	negative selection	6221790
47333233	47333256	3	+	27260156	CADOES1	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.424854793973952	[536]	[420,391,279,395]	-6	hSpCas9	negative selection	6221791
47333217	47333240	3	-	27260156	CADOES1	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.10185696471447186	[344]	[286,257,298,353]	-2	hSpCas9	negative selection	6221792
47322687	47322710	3	+	27260156	EWS502	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.4116294852521636	[193]	[275,259,292,262]	7	hSpCas9	negative selection	6278785
47322697	47322720	3	-	27260156	EWS502	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.5916091820973248	[374]	[550,582,797,458]	8	hSpCas9	negative selection	6278786
47330089	47330112	3	+	27260156	EWS502	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.9918362288466618	[46]	[102,59,170,60]	9	hSpCas9	negative selection	6278787
47319679	47319702	3	-	27260156	EWS502	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.36872117756736056	[410]	[252,362,441,296]	-6	hSpCas9	negative selection	6343041
47333233	47333256	3	+	27260156	EWS502	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.10456702123097598	[536]	[385,373,614,781]	-2	hSpCas9	negative selection	6343042
47333217	47333240	3	-	27260156	EWS502	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	0.005858945897023238	[344]	[240,421,295,530]	0	hSpCas9	negative selection	6343043
47322687	47322710	3	+	27260156	EW8	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.14461331754548823	[193]	[184,249,122,146]	2	hSpCas9	negative selection	6400036
47322697	47322720	3	-	27260156	EW8	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.7347783132479984	[374]	[559,366,442,666]	9	hSpCas9	negative selection	6400037
47330089	47330112	3	+	27260156	EW8	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.7458205059170289	[46]	[5,19,9,54]	-8	hSpCas9	negative selection	6400038
47319679	47319702	3	-	27260156	EW8	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.27793835137369793	[410]	[299,270,219,318]	-5	hSpCas9	negative selection	6464292
47333233	47333256	3	+	27260156	EW8	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.008701809552884687	[536]	[414,369,339,616]	0	hSpCas9	negative selection	6464293
47333217	47333240	3	-	27260156	EW8	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	0.05215355379744563	[344]	[320,243,318,272]	0	hSpCas9	negative selection	6464294
47322687	47322710	3	+	27260156	CORL105	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.4802431806187123	[193]	[434,200,369,275]	8	hSpCas9	negative selection	6521287
47322697	47322720	3	-	27260156	CORL105	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.46785615258234065	[374]	[636,651,513,610]	8	hSpCas9	negative selection	6521288
47330089	47330112	3	+	27260156	CORL105	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	1.5291157984193255	[46]	[206,105,209,122]	9	hSpCas9	negative selection	6521289
47319679	47319702	3	-	27260156	CORL105	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.1940426089010778	[410]	[395,474,348,448]	-4	hSpCas9	negative selection	6585543
47333233	47333256	3	+	27260156	CORL105	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.03604488180456614	[536]	[758,486,782,577]	0	hSpCas9	negative selection	6585544
47333217	47333240	3	-	27260156	CORL105	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.3048218299300633	[344]	[301,265,384,363]	-5	hSpCas9	negative selection	6585545
47322687	47322710	3	+	27260156	HS294T	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.20475015486619919	[193]	[97,99,53,92]	2	hSpCas9	negative selection	6642538
47322697	47322720	3	-	27260156	HS294T	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.7551509815530824	[374]	[327,195,225,216]	8	hSpCas9	negative selection	6642539
47330089	47330112	3	+	27260156	HS294T	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.6530770211662746	[46]	[19,31,28,34]	8	hSpCas9	negative selection	6642540
47319679	47319702	3	-	27260156	HS294T	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.11812356216091566	[410]	[87,203,174,116]	-2	hSpCas9	negative selection	6706794
47333233	47333256	3	+	27260156	HS294T	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.26901673428770756	[536]	[179,121,204,554]	3	hSpCas9	negative selection	6706795
47333217	47333240	3	-	27260156	HS294T	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	0.2693751468826511	[344]	[323,83,96,116]	3	hSpCas9	negative selection	6706796
47322687	47322710	3	+	27260156	HCC44	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.120422610369612	[193]	[321,163,247,237]	2	hSpCas9	negative selection	6763789
47322697	47322720	3	-	27260156	HCC44	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.6130144464166434	[374]	[812,418,815,618]	8	hSpCas9	negative selection	6763790
47330089	47330112	3	+	27260156	HCC44	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.8318119626781546	[46]	[46,11,38,26]	-8	hSpCas9	negative selection	6763791
47319679	47319702	3	-	27260156	HCC44	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	0.14329452509037627	[410]	[499,411,555,598]	2	hSpCas9	negative selection	6828045
47333233	47333256	3	+	27260156	HCC44	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.2981362734014169	[536]	[497,424,565,504]	-5	hSpCas9	negative selection	6828046
47333217	47333240	3	-	27260156	HCC44	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.08818754821224467	[344]	[498,361,287,316]	-1	hSpCas9	negative selection	6828047
47322687	47322710	3	+	27260156	G402	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.29793263283237725	[193]	[380,131,347,304]	4	hSpCas9	negative selection	6885040
47322697	47322720	3	-	27260156	G402	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.4778682851138404	[374]	[720,574,493,758]	6	hSpCas9	negative selection	6885041
47330089	47330112	3	+	27260156	G402	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	1.0159695722944933	[46]	[44,150,222,39]	9	hSpCas9	negative selection	6885042
47319679	47319702	3	-	27260156	G402	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	0.018311061289064318	[410]	[378,665,525,451]	0	hSpCas9	negative selection	6949296
47333233	47333256	3	+	27260156	G402	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.43643804887652393	[536]	[542,447,607,348]	-5	hSpCas9	negative selection	6949297
47333217	47333240	3	-	27260156	G402	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	0.24421978063635105	[344]	[462,398,798,328]	3	hSpCas9	negative selection	6949298
47322687	47322710	3	+	27260156	L33	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.3670801959398339	[193]	[198,128,157,236]	7	hSpCas9	negative selection	7006291
47322697	47322720	3	-	27260156	L33	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.6281791252629341	[374]	[541,255,362,574]	9	hSpCas9	negative selection	7006292
47330089	47330112	3	+	27260156	L33	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.9524654000796473	[46]	[71,52,62,62]	9	hSpCas9	negative selection	7006293
47319679	47319702	3	-	27260156	L33	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.3937956729711032	[410]	[380,129,197,236]	-7	hSpCas9	negative selection	7070547
47333233	47333256	3	+	27260156	L33	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.09554318283357616	[536]	[441,268,337,660]	2	hSpCas9	negative selection	7070548
47333217	47333240	3	-	27260156	L33	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.24674069597129406	[344]	[284,153,159,247]	-5	hSpCas9	negative selection	7070549
47322687	47322710	3	+	27260156	K562	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.45021007515891176	[193]	[238,276,234,195]	6	hSpCas9	negative selection	7127542
47322697	47322720	3	-	27260156	K562	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.38533780372039367	[374]	[260,356,773,337]	5	hSpCas9	negative selection	7127543
47330089	47330112	3	+	27260156	K562	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-2.397883642577059	[46]	[14,1,7,6]	-9	hSpCas9	negative selection	7127544
47319679	47319702	3	-	27260156	K562	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.2667614654865378	[410]	[285,511,280,158]	-3	hSpCas9	negative selection	7191798
47333233	47333256	3	+	27260156	K562	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.706789336527981	[536]	[264,295,248,347]	-7	hSpCas9	negative selection	7191799
47333217	47333240	3	-	27260156	K562	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-1.232033366463261	[344]	[154,167,129,77]	-8	hSpCas9	negative selection	7191800
47322687	47322710	3	+	27260156	HT29	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.4569785566836013	[193]	[376,255,362,297]	8	hSpCas9	negative selection	7248793
47322697	47322720	3	-	27260156	HT29	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.6275322023021123	[374]	[756,578,816,657]	9	hSpCas9	negative selection	7248794
47330089	47330112	3	+	27260156	HT29	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.16952159177159887	[46]	[110,16,53,72]	3	hSpCas9	negative selection	7248795
47319679	47319702	3	-	27260156	HT29	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.37189915613539104	[410]	[551,409,321,284]	-6	hSpCas9	negative selection	7313049
47333233	47333256	3	+	27260156	HT29	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.13346160907151014	[536]	[544,565,692,568]	-3	hSpCas9	negative selection	7313050
47333217	47333240	3	-	27260156	HT29	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	0.1350932424441691	[344]	[499,800,341,253]	2	hSpCas9	negative selection	7313051
47322687	47322710	3	+	27260156	MHHES1	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.24971922067389274	[193]	[347,349,170,197]	4	hSpCas9	negative selection	7370044
47322697	47322720	3	-	27260156	MHHES1	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.5411387989334654	[374]	[351,827,674,585]	8	hSpCas9	negative selection	7370045
47330089	47330112	3	+	27260156	MHHES1	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.0745589760874954	[46]	[58,85,59,26]	1	hSpCas9	negative selection	7370046
47319679	47319702	3	-	27260156	MHHES1	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.19736358431134524	[410]	[666,270,412,297]	-4	hSpCas9	negative selection	7434300
47333233	47333256	3	+	27260156	MHHES1	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.3982194109459827	[536]	[574,444,312,494]	-6	hSpCas9	negative selection	7434301
47333217	47333240	3	-	27260156	MHHES1	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.07147673356425094	[344]	[524,352,361,270]	-1	hSpCas9	negative selection	7434302
47322687	47322710	3	+	27260156	MEWO	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.6611531105748768	[193]	[315,202,347]	9	hSpCas9	negative selection	7491295
47322697	47322720	3	-	27260156	MEWO	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.7207583025525637	[374]	[568,715,446]	9	hSpCas9	negative selection	7491296
47330089	47330112	3	+	27260156	MEWO	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.21026850480844894	[46]	[47,59,43]	4	hSpCas9	negative selection	7491297
47319679	47319702	3	-	27260156	MEWO	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.14535789143933506	[410]	[387,290,371]	-3	hSpCas9	negative selection	7555551
47333233	47333256	3	+	27260156	MEWO	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.05585448678755045	[536]	[570,525,478]	1	hSpCas9	negative selection	7555552
47333217	47333240	3	-	27260156	MEWO	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.17863083080341619	[344]	[349,291,225]	-4	hSpCas9	negative selection	7555553
47322687	47322710	3	+	27260156	LNCAPCLONEFGC	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	1.066388855431103	[193]	[373,351,510,256]	9	hSpCas9	negative selection	7612546
47322697	47322720	3	-	27260156	LNCAPCLONEFGC	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.3409400286640579	[374]	[384,307,519,529]	5	hSpCas9	negative selection	7612547
47330089	47330112	3	+	27260156	LNCAPCLONEFGC	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.23695595685945925	[46]	[8,54,30,47]	-4	hSpCas9	negative selection	7612548
47319679	47319702	3	-	27260156	LNCAPCLONEFGC	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	0.036809174935163724	[410]	[337,421,390,375]	0	hSpCas9	negative selection	7676802
47333233	47333256	3	+	27260156	LNCAPCLONEFGC	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.32110310914474166	[536]	[394,322,432,416]	-5	hSpCas9	negative selection	7676803
47333217	47333240	3	-	27260156	LNCAPCLONEFGC	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.2957877437393815	[344]	[249,283,211,263]	-4	hSpCas9	negative selection	7676804
47322687	47322710	3	+	27260156	PANC0327	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.0907986855685683	[193]	[377,67,207,110]	1	hSpCas9	negative selection	7733797
47322697	47322720	3	-	27260156	PANC0327	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.17448039356763712	[374]	[392,346,472,295]	2	hSpCas9	negative selection	7733798
47330089	47330112	3	+	27260156	PANC0327	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	1.5401923597507767	[46]	[92,223,58,93]	9	hSpCas9	negative selection	7733799
47319679	47319702	3	-	27260156	PANC0327	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.6400367375152719	[410]	[218,156,358,210]	-7	hSpCas9	negative selection	7798053
47333233	47333256	3	+	27260156	PANC0327	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.5203608787695808	[536]	[342,354,249,379]	-6	hSpCas9	negative selection	7798054
47333217	47333240	3	-	27260156	PANC0327	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.3479648059193306	[344]	[240,173,380,175]	-5	hSpCas9	negative selection	7798055
47322687	47322710	3	+	27260156	NCIH2009	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.18957727454741202	[193]	[389,297,254]	2	hSpCas9	negative selection	7855048
47322697	47322720	3	-	27260156	NCIH2009	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.6795852700468936	[374]	[974,780,787]	8	hSpCas9	negative selection	7855049
47330089	47330112	3	+	27260156	NCIH2009	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.6786135796977706	[46]	[170,58,98]	8	hSpCas9	negative selection	7855050
47319679	47319702	3	-	27260156	NCIH2009	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	0.38343927311466386	[410]	[996,357,946]	5	hSpCas9	negative selection	7919304
47333233	47333256	3	+	27260156	NCIH2009	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.16702206508628237	[536]	[867,881,779]	2	hSpCas9	negative selection	7919305
47333217	47333240	3	-	27260156	NCIH2009	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.3610909973526512	[344]	[395,392,339]	-5	hSpCas9	negative selection	7919306
47322687	47322710	3	+	27260156	NCIH1373	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.057354232779833314	[193]	[148,298,179,67]	0	hSpCas9	negative selection	7976299
47322697	47322720	3	-	27260156	NCIH1373	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.8657967026098194	[374]	[1178,830,406,184]	8	hSpCas9	negative selection	7976300
47330089	47330112	3	+	27260156	NCIH1373	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	1.0672977971274622	[46]	[211,130,20,23]	9	hSpCas9	negative selection	7976301
47319679	47319702	3	-	27260156	NCIH1373	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.6451130614320257	[410]	[280,331,236,84]	-6	hSpCas9	negative selection	8040555
47333233	47333256	3	+	27260156	NCIH1373	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.6155721101849638	[536]	[348,579,402,51]	-6	hSpCas9	negative selection	8040556
47333217	47333240	3	-	27260156	NCIH1373	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	0.15625179538476852	[344]	[392,369,512,116]	1	hSpCas9	negative selection	8040557
47322687	47322710	3	+	27260156	PATU8902	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	1.183557352833468	[193]	[631,561,365,999]	9	hSpCas9	negative selection	8097550
47322697	47322720	3	-	27260156	PATU8902	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.6771209217242542	[374]	[772,1209,501,950]	7	hSpCas9	negative selection	8097551
47330089	47330112	3	+	27260156	PATU8902	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.00944479089428052	[46]	[3,45,16,228]	0	hSpCas9	negative selection	8097552
47319679	47319702	3	-	27260156	PATU8902	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	0.21287933984820379	[410]	[548,788,540,821]	2	hSpCas9	negative selection	8161806
47333233	47333256	3	+	27260156	PATU8902	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.008497704965771902	[536]	[850,781,749,559]	0	hSpCas9	negative selection	8161807
47333217	47333240	3	-	27260156	PATU8902	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.4401182547149742	[344]	[655,126,267,383]	-4	hSpCas9	negative selection	8161808
47322687	47322710	3	+	27260156	PANC1	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.4504634808866017	[193]	[95,341,256,236]	7	hSpCas9	negative selection	8218801
47322697	47322720	3	-	27260156	PANC1	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.5192674747327257	[374]	[549,518,439,356]	8	hSpCas9	negative selection	8218802
47330089	47330112	3	+	27260156	PANC1	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.12029481285208332	[46]	[78,21,8,56]	2	hSpCas9	negative selection	8218803
47319679	47319702	3	-	27260156	PANC1	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.2754177844409972	[410]	[172,457,292,276]	-4	hSpCas9	negative selection	8283057
47333233	47333256	3	+	27260156	PANC1	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.45849532632037293	[536]	[277,414,368,298]	-6	hSpCas9	negative selection	8283058
47333217	47333240	3	-	27260156	PANC1	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.34396348201660937	[344]	[183,245,323,187]	-5	hSpCas9	negative selection	8283059
47322687	47322710	3	+	27260156	PANC0813	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.3276133712063093	[193]	[457,146,296,258]	5	hSpCas9	negative selection	8340052
47322697	47322720	3	-	27260156	PANC0813	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.5300875357308271	[374]	[731,584,650,586]	8	hSpCas9	negative selection	8340053
47330089	47330112	3	+	27260156	PANC0813	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	1.5480093298509379	[46]	[135,71,278,156]	9	hSpCas9	negative selection	8340054
47319679	47319702	3	-	27260156	PANC0813	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.21178869877922282	[410]	[480,372,407,410]	-3	hSpCas9	negative selection	8404308
47333233	47333256	3	+	27260156	PANC0813	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.04281606976330349	[536]	[632,743,572,505]	0	hSpCas9	negative selection	8404309
47333217	47333240	3	-	27260156	PANC0813	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.7682805920787286	[344]	[212,240,220,271]	-8	hSpCas9	negative selection	8404310
47322687	47322710	3	+	27260156	RDES	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.28523745879987983	[193]	[240,194,292,381]	4	hSpCas9	negative selection	8461303
47322697	47322720	3	-	27260156	RDES	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.5702087114619816	[374]	[588,497,710,793]	8	hSpCas9	negative selection	8461304
47330089	47330112	3	+	27260156	RDES	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.7201139958847649	[46]	[24,31,30,45]	-8	hSpCas9	negative selection	8461305
47319679	47319702	3	-	27260156	RDES	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.26374656096891824	[410]	[315,337,461,485]	-4	hSpCas9	negative selection	8525559
47333233	47333256	3	+	27260156	RDES	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.18940116096015971	[536]	[498,519,476,682]	-3	hSpCas9	negative selection	8525560
47333217	47333240	3	-	27260156	RDES	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.5373362039087108	[344]	[242,349,214,272]	-7	hSpCas9	negative selection	8525561
47322687	47322710	3	+	27260156	PC3	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.4233913656027464	[193]	[180,296,308,273]	8	hSpCas9	negative selection	8582554
47322697	47322720	3	-	27260156	PC3	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.8397569726195524	[374]	[446,641,1021,734]	9	hSpCas9	negative selection	8582555
47330089	47330112	3	+	27260156	PC3	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.5670733414324771	[46]	[10,61,177,93]	9	hSpCas9	negative selection	8582556
47319679	47319702	3	-	27260156	PC3	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	0.0357643156065498	[410]	[252,370,651,535]	0	hSpCas9	negative selection	8646810
47333233	47333256	3	+	27260156	PC3	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.11595476996577703	[536]	[324,575,1033,624]	2	hSpCas9	negative selection	8646811
47333217	47333240	3	-	27260156	PC3	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.18871533937130286	[344]	[244,313,563,166]	-4	hSpCas9	negative selection	8646812
47322687	47322710	3	+	27260156	PATU8988T	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.4744442141721472	[193]	[359,173,297,195]	7	hSpCas9	negative selection	8703805
47322697	47322720	3	-	27260156	PATU8988T	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.08499230140818065	[374]	[288,443,359,455]	1	hSpCas9	negative selection	8703806
47330089	47330112	3	+	27260156	PATU8988T	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.6115629717832873	[46]	[23,122,81,51]	8	hSpCas9	negative selection	8703807
47319679	47319702	3	-	27260156	PATU8988T	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.38718527108347633	[410]	[250,307,403,245]	-6	hSpCas9	negative selection	8768061
47333233	47333256	3	+	27260156	PATU8988T	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.01956299968019351	[536]	[399,511,641,489]	0	hSpCas9	negative selection	8768062
47333217	47333240	3	-	27260156	PATU8988T	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.10779261623741626	[344]	[253,322,391,264]	-2	hSpCas9	negative selection	8768063
47322687	47322710	3	+	27260156	T47D	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.34006963289346814	[193]	[242,256,286,361]	7	hSpCas9	negative selection	8825056
47322697	47322720	3	-	27260156	T47D	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.4715443080233236	[374]	[535,508,721,663]	8	hSpCas9	negative selection	8825057
47330089	47330112	3	+	27260156	T47D	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.1487384573106394	[46]	[25,76,55,82]	3	hSpCas9	negative selection	8825058
47319679	47319702	3	-	27260156	T47D	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.10085908355360798	[410]	[463,343,463,524]	-2	hSpCas9	negative selection	8889312
47333233	47333256	3	+	27260156	T47D	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.08004803603491978	[536]	[626,684,660,669]	1	hSpCas9	negative selection	8889313
47333217	47333240	3	-	27260156	T47D	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	0.0392871067170763	[344]	[390,369,429,465]	0	hSpCas9	negative selection	8889314
47322687	47322710	3	+	27260156	SU8686	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.531312813421713	[193]	[356,237,266,236]	8	hSpCas9	negative selection	8946307
47322697	47322720	3	-	27260156	SU8686	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.4404465414084455	[374]	[448,389,485,749]	7	hSpCas9	negative selection	8946308
47330089	47330112	3	+	27260156	SU8686	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.4488664112015863	[46]	[23,119,39,66]	7	hSpCas9	negative selection	8946309
47319679	47319702	3	-	27260156	SU8686	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.31046026658735926	[410]	[293,316,389,315]	-5	hSpCas9	negative selection	9010563
47333233	47333256	3	+	27260156	SU8686	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.0646653335340383	[536]	[587,457,652,531]	1	hSpCas9	negative selection	9010564
47333217	47333240	3	-	27260156	SU8686	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.2934929853318648	[344]	[207,340,220,354]	-5	hSpCas9	negative selection	9010565
47322687	47322710	3	+	27260156	SKES1	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.4971975492373957	[193]	[233,295,305,252]	8	hSpCas9	negative selection	9067558
47322697	47322720	3	-	27260156	SKES1	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.3353278646712884	[374]	[553,513,425,412]	7	hSpCas9	negative selection	9067559
47330089	47330112	3	+	27260156	SKES1	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.8001607105202413	[46]	[126,55,83,63]	9	hSpCas9	negative selection	9067560
47319679	47319702	3	-	27260156	SKES1	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.25912496792460205	[410]	[396,398,312,279]	-5	hSpCas9	negative selection	9131814
47333233	47333256	3	+	27260156	SKES1	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.032496151417526625	[536]	[702,671,455,325]	0	hSpCas9	negative selection	9131815
47333217	47333240	3	-	27260156	SKES1	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.41305445781734157	[344]	[267,429,189,175]	-7	hSpCas9	negative selection	9131816
47322687	47322710	3	+	27260156	TOV112D	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.10679734422805898	[193]	[200,301,156,198]	2	hSpCas9	negative selection	9188809
47322697	47322720	3	-	27260156	TOV112D	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.6860460570947776	[374]	[506,639,351,908]	9	hSpCas9	negative selection	9188810
47330089	47330112	3	+	27260156	TOV112D	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.6181488179963464	[46]	[59,195,14,47]	9	hSpCas9	negative selection	9188811
47319679	47319702	3	-	27260156	TOV112D	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	0.2426396284996295	[410]	[700,646,397,264]	4	hSpCas9	negative selection	9253065
47333233	47333256	3	+	27260156	TOV112D	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.18077162995295687	[536]	[481,472,487,454]	-4	hSpCas9	negative selection	9253066
47333217	47333240	3	-	27260156	TOV112D	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.11470857295675357	[344]	[274,702,151,238]	-2	hSpCas9	negative selection	9253067
47322687	47322710	3	+	27260156	TC71	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.4853719772831371	[193]	[321,286,300,250]	9	hSpCas9	negative selection	9310060
47322697	47322720	3	-	27260156	TC71	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.4501930142912336	[374]	[517,565,413,713]	9	hSpCas9	negative selection	9310061
47330089	47330112	3	+	27260156	TC71	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.7706422566916955	[46]	[67,106,115,49]	9	hSpCas9	negative selection	9310062
47319679	47319702	3	-	27260156	TC71	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.29878736810058815	[410]	[332,342,415,337]	-7	hSpCas9	negative selection	9374316
47333233	47333256	3	+	27260156	TC71	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	0.05177633966708867	[536]	[555,521,607,707]	1	hSpCas9	negative selection	9374317
47333217	47333240	3	-	27260156	TC71	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.025017481013445864	[344]	[319,372,393,366]	0	hSpCas9	negative selection	9374318
47322687	47322710	3	+	27260156	TC32	viability	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.6997245311541584	[193]	[257,131,252,602]	9	hSpCas9	negative selection	9431311
47322697	47322720	3	-	27260156	TC32	viability	CATCACCTCACCGTTCTCGAAGG	KLHL18	ENSG00000114648	0.7223030166676275	[374]	[440,491,675,759]	9	hSpCas9	negative selection	9431312
47330089	47330112	3	+	27260156	TC32	viability	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.19698277883914317	[46]	[70,28,48,55]	3	hSpCas9	negative selection	9431313
47319679	47319702	3	-	27260156	TC32	viability	TCGAGGCTGCTAAGACAATCCGG	KLHL18	ENSG00000114648	-0.1440748651778284	[410]	[220,408,420,328]	-3	hSpCas9	negative selection	9495567
47333233	47333256	3	+	27260156	TC32	viability	ATATCCGCCTGCCCCTCTGTCGG	KLHL18	ENSG00000114648	-0.28508262528273476	[536]	[282,320,525,583]	-5	hSpCas9	negative selection	9495568
47333217	47333240	3	-	27260156	TC32	viability	CGGATATTGGACAGCAGCTCAGG	KLHL18	ENSG00000114648	-0.42048298037111137	[344]	[266,148,233,340]	-7	hSpCas9	negative selection	9495569
47283047	47283070	3	+	27869803	HPAFII	viability after 27 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	1.1400279712743882	[258]	[376,235,NaN]	8	hSpCas9	negative selection	9585058
47319730	47319753	3	+	27869803	HPAFII	viability after 27 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	1.1330933068654314	[344]	[165,590,NaN]	8	hSpCas9	negative selection	9585059
47322687	47322710	3	+	27869803	HPAFII	viability after 27 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.927580454375704	[0]	[0,0,NaN]	7	hSpCas9	negative selection	9585060
47330089	47330112	3	+	27869803	HPAFII	viability after 27 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.45470657282633337	[309]	[446,36,NaN]	3	hSpCas9	negative selection	9585061
47333213	47333236	3	-	27869803	HPAFII	viability after 27 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	-0.3471112844045443	[182]	[25,116,NaN]	-3	hSpCas9	negative selection	9585062
47334759	47334782	3	-	27869803	HPAFII	viability after 27 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	1.3940726235095269	[501]	[811,594,NaN]	9	hSpCas9	negative selection	9585063
47283047	47283070	3	+	27869803	HPAFII	viability after 15 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	0.5625778708081065	[258]	[629,274,NaN]	6	hSpCas9	negative selection	9667507
47319730	47319753	3	+	27869803	HPAFII	viability after 15 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.6652455094166646	[344]	[587,587,NaN]	7	hSpCas9	negative selection	9667508
47322687	47322710	3	+	27869803	HPAFII	viability after 15 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	-0.10397428375416773	[0]	[0,0,NaN]	-1	hSpCas9	negative selection	9667509
47330089	47330112	3	+	27869803	HPAFII	viability after 15 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.09589247599919931	[309]	[672,158,NaN]	1	hSpCas9	negative selection	9667510
47333213	47333236	3	-	27869803	HPAFII	viability after 15 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	-0.25299664598066696	[182]	[66,225,NaN]	-3	hSpCas9	negative selection	9667511
47334759	47334782	3	-	27869803	HPAFII	viability after 15 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.7371952392702559	[501]	[1079,786,NaN]	8	hSpCas9	negative selection	9667512
47283047	47283070	3	+	27869803	ASPC1	viability after 36 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	-0.9506414014275824	[607]	[158,109,73]	-7	hSpCas9	negative selection	9749956
47319730	47319753	3	+	27869803	ASPC1	viability after 36 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	0.25410443473576666	[684]	[434,123,304]	2	hSpCas9	negative selection	9749957
47322687	47322710	3	+	27869803	ASPC1	viability after 36 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	-0.2371060834162454	[1293]	[292,330,483]	-2	hSpCas9	negative selection	9749958
47330089	47330112	3	+	27869803	ASPC1	viability after 36 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	-0.02050092213199678	[784]	[388,128,295]	0	hSpCas9	negative selection	9749959
47333213	47333236	3	-	27869803	ASPC1	viability after 36 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	0.14185238907111308	[362]	[86,167,152]	1	hSpCas9	negative selection	9749960
47334759	47334782	3	-	27869803	ASPC1	viability after 36 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.8747217379617624	[1014]	[1560,313,269]	8	hSpCas9	negative selection	9749961
47283047	47283070	3	+	27869803	PATU8988S	viability after 35 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	0.45201158715972606	[590]	[371,278,NaN]	5	hSpCas9	negative selection	9832405
47319730	47319753	3	+	27869803	PATU8988S	viability after 35 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	-0.19812800881565235	[760]	[338,194,NaN]	-2	hSpCas9	negative selection	9832406
47322687	47322710	3	+	27869803	PATU8988S	viability after 35 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.6556205301474624	[1002]	[571,700,NaN]	7	hSpCas9	negative selection	9832407
47330089	47330112	3	+	27869803	PATU8988S	viability after 35 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.7317519026947937	[603]	[391,415,NaN]	7	hSpCas9	negative selection	9832408
47333213	47333236	3	-	27869803	PATU8988S	viability after 35 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	-0.66486052743633	[306]	[72,82,NaN]	-6	hSpCas9	negative selection	9832409
47334759	47334782	3	-	27869803	PATU8988S	viability after 35 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.3683732407075766	[1020]	[673,386,NaN]	4	hSpCas9	negative selection	9832410
47283047	47283070	3	+	27869803	PATU8988S	viability after 31 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	0.09425113495101865	[590]	[284,208,NaN]	1	hSpCas9	negative selection	9914854
47319730	47319753	3	+	27869803	PATU8988S	viability after 31 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	-0.5512612603480801	[760]	[192,224,NaN]	-6	hSpCas9	negative selection	9914855
47322687	47322710	3	+	27869803	PATU8988S	viability after 31 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.2258100124400063	[1002]	[384,572,NaN]	3	hSpCas9	negative selection	9914856
47330089	47330112	3	+	27869803	PATU8988S	viability after 31 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.45640558098062256	[603]	[245,437,NaN]	5	hSpCas9	negative selection	9914857
47333213	47333236	3	-	27869803	PATU8988S	viability after 31 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	-0.5677003643659599	[306]	[42,132,NaN]	-6	hSpCas9	negative selection	9914858
47334759	47334782	3	-	27869803	PATU8988S	viability after 31 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	0.43199388112089654	[1020]	[550,546,NaN]	5	hSpCas9	negative selection	9914859
47283047	47283070	3	+	27869803	HPAFII	viability after 35 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	1.3172756980568352	[258]	[274,384,NaN]	8	hSpCas9	negative selection	9997303
47319730	47319753	3	+	27869803	HPAFII	viability after 35 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	1.3856885266713652	[344]	[128,824,NaN]	8	hSpCas9	negative selection	9997304
47322687	47322710	3	+	27869803	HPAFII	viability after 35 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.9820885529966752	[0]	[0,0,NaN]	6	hSpCas9	negative selection	9997305
47330089	47330112	3	+	27869803	HPAFII	viability after 35 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.031060694046547044	[309]	[276,28,NaN]	0	hSpCas9	negative selection	9997306
47333213	47333236	3	-	27869803	HPAFII	viability after 35 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	0.5891809095572141	[182]	[57,230,NaN]	4	hSpCas9	negative selection	9997307
47334759	47334782	3	-	27869803	HPAFII	viability after 35 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	1.6423906497762004	[501]	[941,625,NaN]	9	hSpCas9	negative selection	9997308
47283047	47283070	3	+	27869803	HPAFII	viability after 31 days	ATGGAGGAGATCCGGCGGCAGGG	KLHL18	ENSG00000114648	0.9776587946475919	[258]	[313,255,NaN]	7	hSpCas9	negative selection	10079752
47319730	47319753	3	+	27869803	HPAFII	viability after 31 days	TGACATGATGGAGTGCAAGCAGG	KLHL18	ENSG00000114648	1.3422459878440365	[344]	[220,784,NaN]	8	hSpCas9	negative selection	10079753
47322687	47322710	3	+	27869803	HPAFII	viability after 31 days	GCTGCACATTCCTTCGAGAACGG	KLHL18	ENSG00000114648	0.8333711996752582	[0]	[0,0,NaN]	6	hSpCas9	negative selection	10079754
47330089	47330112	3	+	27869803	HPAFII	viability after 31 days	CTTGGAAGACGTGCTTGAGCTGG	KLHL18	ENSG00000114648	0.03846960933611898	[309]	[338,3,NaN]	0	hSpCas9	negative selection	10079755
47333213	47333236	3	-	27869803	HPAFII	viability after 31 days	TATTGGACAGCAGCTCAGGCAGG	KLHL18	ENSG00000114648	-0.5185711553090203	[182]	[8,139,NaN]	-3	hSpCas9	negative selection	10079756
47334759	47334782	3	-	27869803	HPAFII	viability after 31 days	GCGATGGATGTGCAGCAGCGTGG	KLHL18	ENSG00000114648	1.1988919844092265	[501]	[763,518,NaN]	8	hSpCas9	negative selection	10079757
47282953	47282976	3	+	28162770	P31FUJ	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-5.5726522072990035	[242]	[5]	-9	hSpCas9	negative selection	10180398
47333240	47333263	3	-	28162770	P31FUJ	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	0.43123186729797613	[141]	[224]	5	hSpCas9	negative selection	10180399
47283042	47283065	3	+	28162770	P31FUJ	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	-0.6101692857271677	[125]	[96]	-5	hSpCas9	negative selection	10180400
47334683	47334706	3	+	28162770	P31FUJ	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	0.3168848215592469	[137]	[201]	3	hSpCas9	negative selection	10180401
47282965	47282988	3	+	28162770	P31FUJ	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	-0.18443918285297967	[87]	[90]	-2	hSpCas9	negative selection	10180402
47319676	47319699	3	-	28162770	P31FUJ	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	-0.6870244872540662	[310]	[226]	-5	hSpCas9	negative selection	10180403
47333182	47333205	3	+	28162770	P31FUJ	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	-0.13658688915507555	[115]	[123]	-1	hSpCas9	negative selection	10180404
47334775	47334798	3	-	28162770	P31FUJ	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	0.6891952835843482	[18]	[35]	7	hSpCas9	negative selection	10180405
47336661	47336684	3	+	28162770	P31FUJ	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	-0.3523838201670513	[263]	[242]	-3	hSpCas9	negative selection	10180406
47336677	47336700	3	+	28162770	P31FUJ	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	-0.4726292190868472	[443]	[375]	-4	hSpCas9	negative selection	10180407
47282953	47282976	3	+	28162770	TF1	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	NaN	[NaN]	[22]	1	hSpCas9	negative selection	10349764
47333240	47333263	3	-	28162770	TF1	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	NaN	[NaN]	[400]	1	hSpCas9	negative selection	10349765
47283042	47283065	3	+	28162770	TF1	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	NaN	[NaN]	[65]	1	hSpCas9	negative selection	10349766
47334683	47334706	3	+	28162770	TF1	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	NaN	[NaN]	[186]	1	hSpCas9	negative selection	10349767
47282965	47282988	3	+	28162770	TF1	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	NaN	[NaN]	[52]	1	hSpCas9	negative selection	10349768
47319676	47319699	3	-	28162770	TF1	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	NaN	[NaN]	[270]	1	hSpCas9	negative selection	10349769
47333182	47333205	3	+	28162770	TF1	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	NaN	[NaN]	[211]	1	hSpCas9	negative selection	10349770
47334775	47334798	3	-	28162770	TF1	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	NaN	[NaN]	[18]	1	hSpCas9	negative selection	10349771
47336661	47336684	3	+	28162770	TF1	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	NaN	[NaN]	[213]	1	hSpCas9	negative selection	10349772
47336677	47336700	3	+	28162770	TF1	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	NaN	[NaN]	[144]	1	hSpCas9	negative selection	10349773
47282953	47282976	3	+	28162770	SKM1	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-2.2473075327546765	[93]	[34]	-8	hSpCas9	negative selection	10519130
47333240	47333263	3	-	28162770	SKM1	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	0.34305754824849094	[32]	[73]	3	hSpCas9	negative selection	10519131
47283042	47283065	3	+	28162770	SKM1	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	0.05246741989413539	[35]	[65]	0	hSpCas9	negative selection	10519132
47334683	47334706	3	+	28162770	SKM1	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	-0.6699986045769556	[53]	[59]	-5	hSpCas9	negative selection	10519133
47282965	47282988	3	+	28162770	SKM1	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	0.10399772053421752	[19]	[37]	1	hSpCas9	negative selection	10519134
47319676	47319699	3	-	28162770	SKM1	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	-0.4032885405997633	[97]	[130]	-3	hSpCas9	negative selection	10519135
47333182	47333205	3	+	28162770	SKM1	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	0.41065905876826947	[19]	[46]	4	hSpCas9	negative selection	10519136
47334775	47334798	3	-	28162770	SKM1	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	2.116597757313851	[2]	[22]	9	hSpCas9	negative selection	10519137
47336661	47336684	3	+	28162770	SKM1	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	0.0690639304248305	[54]	[101]	0	hSpCas9	negative selection	10519138
47336677	47336700	3	+	28162770	SKM1	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	-1.2022737791401727	[81]	[62]	-7	hSpCas9	negative selection	10519139
47282953	47282976	3	+	28162770	SKM1	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-2.2473075327546765	[93]	[34]	-8	hSpCas9	negative selection	10688496
47333240	47333263	3	-	28162770	SKM1	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	0.34305754824849094	[32]	[73]	3	hSpCas9	negative selection	10688497
47283042	47283065	3	+	28162770	SKM1	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	0.05246741989413539	[35]	[65]	0	hSpCas9	negative selection	10688498
47334683	47334706	3	+	28162770	SKM1	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	-0.6699986045769556	[53]	[59]	-5	hSpCas9	negative selection	10688499
47282965	47282988	3	+	28162770	SKM1	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	0.10399772053421752	[19]	[37]	1	hSpCas9	negative selection	10688500
47319676	47319699	3	-	28162770	SKM1	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	-0.4032885405997633	[97]	[130]	-3	hSpCas9	negative selection	10688501
47333182	47333205	3	+	28162770	SKM1	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	0.41065905876826947	[19]	[46]	4	hSpCas9	negative selection	10688502
47334775	47334798	3	-	28162770	SKM1	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	2.116597757313851	[2]	[22]	9	hSpCas9	negative selection	10688503
47336661	47336684	3	+	28162770	SKM1	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	0.0690639304248305	[54]	[101]	0	hSpCas9	negative selection	10688504
47336677	47336700	3	+	28162770	SKM1	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	-1.2022737791401727	[81]	[62]	-7	hSpCas9	negative selection	10688505
47282953	47282976	3	+	28162770	PL21	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-1.246943611720332	[348]	[63]	-7	hSpCas9	negative selection	10857862
47333240	47333263	3	-	28162770	PL21	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	1.5949992318305335	[107]	[141]	9	hSpCas9	negative selection	10857863
47283042	47283065	3	+	28162770	PL21	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	1.3209940093637058	[102]	[111]	9	hSpCas9	negative selection	10857864
47334683	47334706	3	+	28162770	PL21	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	-1.1217884803980422	[164]	[32]	-6	hSpCas9	negative selection	10857865
47282965	47282988	3	+	28162770	PL21	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	-2.095316269036851	[107]	[10]	-8	hSpCas9	negative selection	10857866
47319676	47319699	3	-	28162770	PL21	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	0.45905791185088207	[350]	[209]	4	hSpCas9	negative selection	10857867
47333182	47333205	3	+	28162770	PL21	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	1.136945788002126	[69]	[66]	8	hSpCas9	negative selection	10857868
47334775	47334798	3	-	28162770	PL21	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-0.7998603855106801	[3]	[0]	-5	hSpCas9	negative selection	10857869
47336661	47336684	3	+	28162770	PL21	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	0.2630708702157768	[156]	[81]	2	hSpCas9	negative selection	10857870
47336677	47336700	3	+	28162770	PL21	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	-0.10102992023124485	[275]	[111]	0	hSpCas9	negative selection	10857871
47282953	47282976	3	+	28162770	P31FUJ	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-5.5726522072990035	[242]	[5]	-9	hSpCas9	negative selection	11027228
47333240	47333263	3	-	28162770	P31FUJ	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	0.43123186729797613	[141]	[224]	5	hSpCas9	negative selection	11027229
47283042	47283065	3	+	28162770	P31FUJ	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	-0.6101692857271677	[125]	[96]	-5	hSpCas9	negative selection	11027230
47334683	47334706	3	+	28162770	P31FUJ	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	0.3168848215592469	[137]	[201]	3	hSpCas9	negative selection	11027231
47282965	47282988	3	+	28162770	P31FUJ	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	-0.18443918285297967	[87]	[90]	-2	hSpCas9	negative selection	11027232
47319676	47319699	3	-	28162770	P31FUJ	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	-0.6870244872540662	[310]	[226]	-5	hSpCas9	negative selection	11027233
47333182	47333205	3	+	28162770	P31FUJ	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	-0.13658688915507555	[115]	[123]	-1	hSpCas9	negative selection	11027234
47334775	47334798	3	-	28162770	P31FUJ	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	0.6891952835843482	[18]	[35]	7	hSpCas9	negative selection	11027235
47336661	47336684	3	+	28162770	P31FUJ	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	-0.3523838201670513	[263]	[242]	-3	hSpCas9	negative selection	11027236
47336677	47336700	3	+	28162770	P31FUJ	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	-0.4726292190868472	[443]	[375]	-4	hSpCas9	negative selection	11027237
47282953	47282976	3	+	28162770	OCIAML5	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-4.876450729490956	[178]	[10]	-9	hSpCas9	negative selection	11196594
47333240	47333263	3	-	28162770	OCIAML5	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	0.3267365819247682	[71]	[162]	2	hSpCas9	negative selection	11196595
47283042	47283065	3	+	28162770	OCIAML5	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	1.329683865975105	[53]	[244]	9	hSpCas9	negative selection	11196596
47334683	47334706	3	+	28162770	OCIAML5	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	-0.43456081599440355	[145]	[194]	-3	hSpCas9	negative selection	11196597
47282965	47282988	3	+	28162770	OCIAML5	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	0.004569253964825659	[36]	[66]	0	hSpCas9	negative selection	11196598
47319676	47319699	3	-	28162770	OCIAML5	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	0.355926471411835	[186]	[431]	3	hSpCas9	negative selection	11196599
47333182	47333205	3	+	28162770	OCIAML5	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	0.5963939299522971	[47]	[130]	5	hSpCas9	negative selection	11196600
47334775	47334798	3	-	28162770	OCIAML5	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	0.23539627038634237	[7]	[16]	2	hSpCas9	negative selection	11196601
47336661	47336684	3	+	28162770	OCIAML5	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	0.18847158901088024	[192]	[396]	1	hSpCas9	negative selection	11196602
47336677	47336700	3	+	28162770	OCIAML5	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	0.061156986300430094	[196]	[370]	0	hSpCas9	negative selection	11196603
47282953	47282976	3	+	28162770	EOL1	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-2.9545978335550798	[514]	[34]	-9	hSpCas9	negative selection	11365960
47333240	47333263	3	-	28162770	EOL1	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	1.3551821259003969	[137]	[185]	9	hSpCas9	negative selection	11365961
47283042	47283065	3	+	28162770	EOL1	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	0.470829804127631	[188]	[137]	4	hSpCas9	negative selection	11365962
47334683	47334706	3	+	28162770	EOL1	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	0.5456296980983426	[354]	[272]	5	hSpCas9	negative selection	11365963
47282965	47282988	3	+	28162770	EOL1	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	-1.8196133239998753	[200]	[29]	-8	hSpCas9	negative selection	11365964
47319676	47319699	3	-	28162770	EOL1	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	-0.7859456112344805	[683]	[208]	-5	hSpCas9	negative selection	11365965
47333182	47333205	3	+	28162770	EOL1	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	0.06750572541257771	[95]	[52]	0	hSpCas9	negative selection	11365966
47334775	47334798	3	-	28162770	EOL1	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-1.660414729150622	[17]	[2]	-8	hSpCas9	negative selection	11365967
47336661	47336684	3	+	28162770	EOL1	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	-0.44468603809518464	[278]	[107]	-3	hSpCas9	negative selection	11365968
47336677	47336700	3	+	28162770	EOL1	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	0.3358907872916368	[390]	[259]	3	hSpCas9	negative selection	11365969
47282953	47282976	3	+	28162770	MOLM13	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-2.3394655405130256	[412]	[58]	-8	hSpCas9	negative selection	11535326
47333240	47333263	3	-	28162770	MOLM13	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	-0.16014184106846352	[152]	[98]	-1	hSpCas9	negative selection	11535327
47283042	47283065	3	+	28162770	MOLM13	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	0.8448588399899031	[143]	[186]	6	hSpCas9	negative selection	11535328
47334683	47334706	3	+	28162770	MOLM13	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	0.1017614827466814	[231]	[179]	0	hSpCas9	negative selection	11535329
47282965	47282988	3	+	28162770	MOLM13	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	0.9775637549614977	[117]	[167]	7	hSpCas9	negative selection	11535330
47319676	47319699	3	-	28162770	MOLM13	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	-0.13466717919131566	[494]	[325]	-1	hSpCas9	negative selection	11535331
47333182	47333205	3	+	28162770	MOLM13	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	1.3423584994607198	[71]	[131]	8	hSpCas9	negative selection	11535332
47334775	47334798	3	-	28162770	MOLM13	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-0.339465540513026	[13]	[7]	-2	hSpCas9	negative selection	11535333
47336661	47336684	3	+	28162770	MOLM13	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	0.11399217707963905	[307]	[240]	0	hSpCas9	negative selection	11535334
47336677	47336700	3	+	28162770	MOLM13	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	-0.3129121214717089	[322]	[187]	-2	hSpCas9	negative selection	11535335
47282953	47282976	3	+	28162770	HEL	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-2.9422236687207994	[443]	[36]	-8	hSpCas9	negative selection	11704692
47333240	47333263	3	-	28162770	HEL	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	-0.7688920658352373	[140]	[52]	-5	hSpCas9	negative selection	11704693
47283042	47283065	3	+	28162770	HEL	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	0.5625684833163737	[147]	[139]	5	hSpCas9	negative selection	11704694
47334683	47334706	3	+	28162770	HEL	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	-0.4225526282513622	[225]	[107]	-3	hSpCas9	negative selection	11704695
47282965	47282988	3	+	28162770	HEL	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	0.21042334128967777	[111]	[82]	1	hSpCas9	negative selection	11704696
47319676	47319699	3	-	28162770	HEL	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	0.4966363399949911	[487]	[440]	4	hSpCas9	negative selection	11704697
47333182	47333205	3	+	28162770	HEL	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	-0.8877758846984225	[51]	[17]	-5	hSpCas9	negative selection	11704698
47334775	47334798	3	-	28162770	HEL	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-1.5796535893360915	[13]	[2]	-7	hSpCas9	negative selection	11704699
47336661	47336684	3	+	28162770	HEL	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	-0.23723046429287298	[218]	[118]	-2	hSpCas9	negative selection	11704700
47336677	47336700	3	+	28162770	HEL	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	-0.6998159134769633	[316]	[124]	-4	hSpCas9	negative selection	11704701
47282953	47282976	3	+	28162770	MV411	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-3.8400252904675645	[322]	[18]	-9	hSpCas9	negative selection	11874058
47333240	47333263	3	-	28162770	MV411	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	0.9351137379525101	[130]	[210]	8	hSpCas9	negative selection	11874059
47283042	47283065	3	+	28162770	MV411	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	0.6030965029826874	[92]	[118]	5	hSpCas9	negative selection	11874060
47334683	47334706	3	+	28162770	MV411	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	-0.7855775064451875	[220]	[107]	-5	hSpCas9	negative selection	11874061
47282965	47282988	3	+	28162770	MV411	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	-0.9308996904757374	[85]	[37]	-6	hSpCas9	negative selection	11874062
47319676	47319699	3	-	28162770	MV411	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	0.0756130164249813	[284]	[252]	0	hSpCas9	negative selection	11874063
47333182	47333205	3	+	28162770	MV411	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	-0.0246419946540255	[63]	[52]	0	hSpCas9	negative selection	11874064
47334775	47334798	3	-	28162770	MV411	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	3.2474375507827755	[1]	[15]	9	hSpCas9	negative selection	11874065
47336661	47336684	3	+	28162770	MV411	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	0.052709158339890566	[197]	[172]	0	hSpCas9	negative selection	11874066
47336677	47336700	3	+	28162770	MV411	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	0.169993465357427	[286]	[271]	1	hSpCas9	negative selection	11874067
47282953	47282976	3	+	28162770	MONOMAC1	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-1.3063354895503654	[232]	[107]	-7	hSpCas9	negative selection	12043424
47333240	47333263	3	-	28162770	MONOMAC1	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	0.7923159087409378	[67]	[134]	7	hSpCas9	negative selection	12043425
47283042	47283065	3	+	28162770	MONOMAC1	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	0.1591069631657216	[49]	[63]	1	hSpCas9	negative selection	12043426
47334683	47334706	3	+	28162770	MONOMAC1	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	-0.5536019436189334	[136]	[106]	-5	hSpCas9	negative selection	12043427
47282965	47282988	3	+	28162770	MONOMAC1	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	-1.0403113433721005	[60]	[33]	-7	hSpCas9	negative selection	12043428
47319676	47319699	3	-	28162770	MONOMAC1	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	0.2340605031153894	[200]	[270]	2	hSpCas9	negative selection	12043429
47333182	47333205	3	+	28162770	MONOMAC1	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	0.8554305728345819	[26]	[55]	7	hSpCas9	negative selection	12043430
47334775	47334798	3	-	28162770	MONOMAC1	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-1.78199934778071	[2]	[0]	-8	hSpCas9	negative selection	12043431
47336661	47336684	3	+	28162770	MONOMAC1	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	-0.7934041110529593	[126]	[83]	-6	hSpCas9	negative selection	12043432
47336677	47336700	3	+	28162770	MONOMAC1	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	-0.09192014124533954	[171]	[184]	-1	hSpCas9	negative selection	12043433
47282953	47282976	3	+	28162770	OCIAML2	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-2.515023944600615	[65]	[63]	-8	hSpCas9	negative selection	12212790
47333240	47333263	3	-	28162770	OCIAML2	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	-0.28620525410473385	[21]	[99]	-2	hSpCas9	negative selection	12212791
47283042	47283065	3	+	28162770	OCIAML2	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	0.06280237483891293	[18]	[109]	0	hSpCas9	negative selection	12212792
47334683	47334706	3	+	28162770	OCIAML2	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	-0.20592659904774874	[35]	[172]	-2	hSpCas9	negative selection	12212793
47282965	47282988	3	+	28162770	OCIAML2	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	0.8128241218305655	[18]	[184]	7	hSpCas9	negative selection	12212794
47319676	47319699	3	-	28162770	OCIAML2	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	-0.15998753790131404	[76]	[381]	-1	hSpCas9	negative selection	12212795
47333182	47333205	3	+	28162770	OCIAML2	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	-0.1905219060494261	[13]	[67]	-1	hSpCas9	negative selection	12212796
47334775	47334798	3	-	28162770	OCIAML2	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	-0.5961607073260202	[2]	[10]	-4	hSpCas9	negative selection	12212797
47336661	47336684	3	+	28162770	OCIAML2	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	0.2857010937909761	[36]	[249]	2	hSpCas9	negative selection	12212798
47336677	47336700	3	+	28162770	OCIAML2	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	-0.3621053684639922	[47]	[206]	-3	hSpCas9	negative selection	12212799
47282953	47282976	3	+	28162770	OCIAML3	viability	GCGGCCGGGGAAGATGGTGGAGG	KLHL18	ENSG00000114648	-2.169122355088972	[72]	[48]	-8	hSpCas9	negative selection	12382156
47333240	47333263	3	-	28162770	OCIAML3	viability	ACTGGGGCCGACAGAGGGGCAGG	KLHL18	ENSG00000114648	0.7491369404728949	[26]	[136]	6	hSpCas9	negative selection	12382157
47283042	47283065	3	+	28162770	OCIAML3	viability	GCGTCATGGAGGAGATCCGGCGG	KLHL18	ENSG00000114648	1.167832622481072	[22]	[155]	8	hSpCas9	negative selection	12382158
47334683	47334706	3	+	28162770	OCIAML3	viability	GGACCTGGTAGACGAAGCAAAGG	KLHL18	ENSG00000114648	0.17152710603881405	[34]	[118]	1	hSpCas9	negative selection	12382159
47282965	47282988	3	+	28162770	OCIAML3	viability	GATGGTGGAGGACGGCGCGGAGG	KLHL18	ENSG00000114648	-1.2069845172149158	[38]	[50]	-7	hSpCas9	negative selection	12382160
47319676	47319699	3	-	28162770	OCIAML3	viability	AGGCTGCTAAGACAATCCGGTGG	KLHL18	ENSG00000114648	-0.8284728939611861	[99]	[169]	-6	hSpCas9	negative selection	12382161
47333182	47333205	3	+	28162770	OCIAML3	viability	TCAGATACGACCGGGAGCAGAGG	KLHL18	ENSG00000114648	0.585316059120399	[16]	[76]	5	hSpCas9	negative selection	12382162
47334775	47334798	3	-	28162770	OCIAML3	viability	AGCGTAGATAAGTCCAGCGATGG	KLHL18	ENSG00000114648	3.213347281733441	[0]	[27]	9	hSpCas9	negative selection	12382163
47336661	47336684	3	+	28162770	OCIAML3	viability	GAGGATATGACGGCCAGCTACGG	KLHL18	ENSG00000114648	-0.6623946153044132	[53]	[102]	-5	hSpCas9	negative selection	12382164
47336677	47336700	3	+	28162770	OCIAML3	viability	GCTACGGCTGAGCACTGTGGAGG	KLHL18	ENSG00000114648	0.17354627367546593	[83]	[285]	1	hSpCas9	negative selection	12382165