| 25227295 | 25227318 | 12 | - | 26472758 | Jiyoye | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | 3.010516411541884 | [12] | [78] | 9 | hSpCas9 | negative selection | 86069 | 25245310 | 25245333 | 12 | + | 26472758 | Jiyoye | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | 5.53645839845084 | [0] | [34] | 9 | hSpCas9 | negative selection | 86070 | 25245341 | 25245364 | 12 | - | 26472758 | Jiyoye | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | -0.17288831980244357 | [440] | [294] | -1 | hSpCas9 | negative selection | 86071 | 25227320 | 25227343 | 12 | - | 26472758 | Jiyoye | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | -0.06489306280934914 | [257] | [185] | 0 | hSpCas9 | negative selection | 86072 | 25225730 | 25225753 | 12 | - | 26472758 | Jiyoye | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | 0.034900201857831936 | [276] | [213] | 0 | hSpCas9 | negative selection | 86073 | 25225670 | 25225693 | 12 | - | 26472758 | Jiyoye | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | -0.8061291670026156 | [210] | [90] | -5 | hSpCas9 | negative selection | 86074 | 25227305 | 25227328 | 12 | - | 26472758 | Jiyoye | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.6042122285654273 | [40] | [46] | 4 | hSpCas9 | negative selection | 86075 | 25227345 | 25227368 | 12 | - | 26472758 | Jiyoye | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | -0.40854840408888693 | [388] | [220] | -3 | hSpCas9 | negative selection | 86076 | 25227295 | 25227318 | 12 | - | 26472758 | KBM7 | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | -0.8695937252097419 | [613,473] | [75,194] | -6 | hSpCas9 | negative selection | 277187 | 25245310 | 25245333 | 12 | + | 26472758 | KBM7 | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | 0.6002542305077794 | [352,266] | [248,191] | 6 | hSpCas9 | negative selection | 277188 | 25245341 | 25245364 | 12 | - | 26472758 | KBM7 | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | -3.1747945044492845 | [1678,1161] | [73,71] | -9 | hSpCas9 | negative selection | 277189 | 25227320 | 25227343 | 12 | - | 26472758 | KBM7 | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | -1.7049922630486136 | [941,926] | [185,89] | -8 | hSpCas9 | negative selection | 277190 | 25225730 | 25225753 | 12 | - | 26472758 | KBM7 | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | -1.3636507508021125 | [1059,699] | [125,186] | -7 | hSpCas9 | negative selection | 277191 | 25225670 | 25225693 | 12 | - | 26472758 | KBM7 | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | -0.8985289410750164 | [559,402] | [166,77] | -6 | hSpCas9 | negative selection | 277192 | 25227305 | 25227328 | 12 | - | 26472758 | KBM7 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -1.1215554061952717 | [512,289] | [89,79] | -7 | hSpCas9 | negative selection | 277193 | 25227345 | 25227368 | 12 | - | 26472758 | KBM7 | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | 0.1570460164363483 | [1164,901] | [491,577] | 1 | hSpCas9 | negative selection | 277194 | 25227295 | 25227318 | 12 | - | 26472758 | Raji | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | -0.5739834493006191 | [262] | [40] | -4 | hSpCas9 | negative selection | 468305 | 25245310 | 25245333 | 12 | + | 26472758 | Raji | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | -0.8510373608750008 | [170] | [21] | -6 | hSpCas9 | negative selection | 468306 | 25245341 | 25245364 | 12 | - | 26472758 | Raji | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | 0.005845508911537234 | [617] | [143] | 0 | hSpCas9 | negative selection | 468307 | 25227320 | 25227343 | 12 | - | 26472758 | Raji | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | 0.31063671288197625 | [270] | [77] | 3 | hSpCas9 | negative selection | 468308 | 25225730 | 25225753 | 12 | - | 26472758 | Raji | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | 0.48135837803055714 | [391] | [126] | 4 | hSpCas9 | negative selection | 468309 | 25225670 | 25225693 | 12 | - | 26472758 | Raji | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | -0.1780186834886488 | [311] | [63] | -1 | hSpCas9 | negative selection | 468310 | 25227305 | 25227328 | 12 | - | 26472758 | Raji | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -1.0355744184684437 | [158] | [17] | -6 | hSpCas9 | negative selection | 468311 | 25227345 | 25227368 | 12 | - | 26472758 | Raji | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | 1.2196497676245115 | [345] | [186] | 9 | hSpCas9 | negative selection | 468312 | 25227295 | 25227318 | 12 | - | 26472758 | K562 | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | -0.6573172560186872 | [453] | [242] | -4 | hSpCas9 | negative selection | 659423 | 25245310 | 25245333 | 12 | + | 26472758 | K562 | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | 0.022026306329999024 | [160] | [137] | 0 | hSpCas9 | negative selection | 659424 | 25245341 | 25245364 | 12 | - | 26472758 | K562 | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | -0.6177720604712575 | [1286] | [707] | -4 | hSpCas9 | negative selection | 659425 | 25227320 | 25227343 | 12 | - | 26472758 | K562 | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | -0.007327606417263266 | [661] | [555] | 0 | hSpCas9 | negative selection | 659426 | 25225730 | 25225753 | 12 | - | 26472758 | K562 | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | -0.07155464408329426 | [543] | [436] | 0 | hSpCas9 | negative selection | 659427 | 25225670 | 25225693 | 12 | - | 26472758 | K562 | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | 0.5779451479670682 | [445] | [561] | 5 | hSpCas9 | negative selection | 659428 | 25227305 | 25227328 | 12 | - | 26472758 | K562 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -0.006475115295134781 | [212] | [178] | 0 | hSpCas9 | negative selection | 659429 | 25227345 | 25227368 | 12 | - | 26472758 | K562 | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | 0.29090774554165244 | [854] | [882] | 2 | hSpCas9 | negative selection | 659430 | 25220867 | 25220890 | 12 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | ATACAAAAATCAGTCAGGTGTGG | KRAS | ENSG00000133703 | 0.6473066130133476 | [37,123] | [42,11] | 2 | dCas9-VP64 | positive selection | 2389526 | 25216428 | 25216451 | 12 | - | 25494202 | A375 | resistance to PLX-4720 (puromycin) | ATACAAAAATCAGTCAGGTGTGG | KRAS | ENSG00000133703 | 0.6473066130133476 | [37,123] | [42,11] | 2 | dCas9-VP64 | positive selection | 2389531 | 25249330 | 25249353 | 12 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GAGGTTGCAGTGAGCCGAGACGG | KRAS | ENSG00000133703 | 0.6330757747468561 | [50,16] | [8,13] | 2 | dCas9-VP64 | positive selection | 2476958 | 25220867 | 25220890 | 12 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | ATACAAAAATCAGTCAGGTGTGG | KRAS | ENSG00000133703 | 0.8677968216831808 | [99,192] | [113,60] | 6 | dCas9-VP64 | positive selection | 2484781 | 25216428 | 25216451 | 12 | - | 25494202 | A375 | resistance to PLX-4720 (zeocin) | ATACAAAAATCAGTCAGGTGTGG | KRAS | ENSG00000133703 | 0.8677968216831808 | [99,192] | [113,60] | 6 | dCas9-VP64 | positive selection | 2484786 | 25249330 | 25249353 | 12 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GAGGTTGCAGTGAGCCGAGACGG | KRAS | ENSG00000133703 | 0.34517561365305327 | [29,16] | [7,9] | 2 | dCas9-VP64 | positive selection | 2572213 | 25227387 | 25227410 | 12 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | AATTACTACTTGCTTCCTGTAGG | KRAS | ENSG00000133703 | -0.48544145692218366 | [3,3] | [3,0] | -6 | hSpCas9 | positive selection | 2998069 | 25227319 | 25227342 | 12 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | AGAGGAGTACAGTGCAATGAGGG | KRAS | ENSG00000133703 | -0.38423891445620306 | [3,3] | [4,0] | -5 | hSpCas9 | positive selection | 2998070 | 25245273 | 25245296 | 12 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | CGAATATGATCCAACAATAGAGG | KRAS | ENSG00000133703 | 0.8456355625647127 | [3,3] | [2,8] | 9 | hSpCas9 | positive selection | 2998071 | 25227401 | 25227424 | 12 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | TCCCTTCTCAGGATTCCTACAGG | KRAS | ENSG00000133703 | 0.2640035084151677 | [3,3] | [3,4] | 5 | hSpCas9 | positive selection | 2998072 | 25227387 | 25227410 | 12 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | AATTACTACTTGCTTCCTGTAGG | KRAS | ENSG00000133703 | -0.3308224085009439 | [3,3] | [2,0] | -5 | hSpCas9 | positive selection | 3065927 | 25227319 | 25227342 | 12 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | AGAGGAGTACAGTGCAATGAGGG | KRAS | ENSG00000133703 | -0.532702922234199 | [3,3] | [2,0] | -7 | hSpCas9 | positive selection | 3065928 | 25245273 | 25245296 | 12 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | CGAATATGATCCAACAATAGAGG | KRAS | ENSG00000133703 | -0.26288269102465645 | [3,3] | [3,0] | -4 | hSpCas9 | positive selection | 3065929 | 25227401 | 25227424 | 12 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | TCCCTTCTCAGGATTCCTACAGG | KRAS | ENSG00000133703 | 0.4429044156256772 | [3,3] | [4,3] | 7 | hSpCas9 | positive selection | 3065930 | 25227305 | 25227328 | | - | 24336571 | A375 | resistance to PLX after 7 days | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.32510746461648093 | [9,7] | [10,10] | 8 | hSpCas9 | positive selection | 3123686 | 25227305 | 25227328 | | - | 24336571 | A375 | resistance to PLX after 14 days | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 1.5824639687484234 | [5,9] | [9,12] | 9 | hSpCas9 | positive selection | 3181479 | 25227305 | 25227328 | | - | 24336571 | A375 | viability after 7 days | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.43468400032753324 | [6] | [9,7] | 6 | hSpCas9 | negative selection | 3239272 | 25227305 | 25227328 | | - | 24336571 | A375 | viability after 14 days | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.3004107685820525 | [6] | [5,9] | 4 | hSpCas9 | negative selection | 3297065 | 25225720 | 25225743 | 12 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | 0.16986337019549572 | [135,135] | [0,0] | 0 | hSpCas9 | positive selection | 3376209 | 25215475 | 25215498 | 12 | - | 27383988 | 293T | resistance to West Nile virus (flavivirus) | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | 1.797894592808538 | [43,43] | [0,0] | 7 | hSpCas9 | positive selection | 3376210 | 25227386 | 25227409 | 12 | + | 26780180 | HT29 | viability (Avana library 4 designs) | AATTACTACTTGCTTCCTGTAGG | KRAS | ENSG00000133703 | 1.71830040893906 | [] | [] | 6 | hSpCas9 | negative selection | 3435521 | 25227319 | 25227342 | 12 | - | 26780180 | HT29 | viability (Avana library 4 designs) | AGAGGAGTACAGTGCAATGAGGG | KRAS | ENSG00000133703 | 1.66439377439668 | [] | [] | 6 | hSpCas9 | negative selection | 3435522 | 25245273 | 25245296 | 12 | - | 26780180 | HT29 | viability (Avana library 4 designs) | CGAATATGATCCAACAATAGAGG | KRAS | ENSG00000133703 | 2.97187545772855 | [] | [] | 8 | hSpCas9 | negative selection | 3435523 | 25227401 | 25227424 | 12 | - | 26780180 | HT29 | viability (Avana library 4 designs) | TCCCTTCTCAGGATTCCTACAGG | KRAS | ENSG00000133703 | 0.928184980653495 | [] | [] | 3 | hSpCas9 | negative selection | 3435524 | 25227401 | 25227424 | 12 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TCCCTTCTCAGGATTCCTACAGG | KRAS | ENSG00000133703 | 2.28822753636483 | [] | [] | 3 | hSpCas9 | negative selection | 3523129 | 25227386 | 25227409 | 12 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | AATTACTACTTGCTTCCTGTAGG | KRAS | ENSG00000133703 | -9.51421387458573 | [] | [] | -7 | hSpCas9 | negative selection | 3523130 | 25227319 | 25227342 | 12 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | AGAGGAGTACAGTGCAATGAGGG | KRAS | ENSG00000133703 | 1.12943185576063 | [] | [] | 1 | hSpCas9 | negative selection | 3523131 | 25245273 | 25245296 | 12 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CGAATATGATCCAACAATAGAGG | KRAS | ENSG00000133703 | -12.6105103147737 | [] | [] | -8 | hSpCas9 | negative selection | 3523132 | 25227337 | 25227360 | 12 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -3.58368508760022 | [] | [] | -4 | hSpCas9 | negative selection | 3523133 | 25227298 | 25227321 | 12 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GGACCAGTACATGAGGACTGGGG | KRAS | ENSG00000133703 | 3.17425362768997 | [] | [] | 5 | hSpCas9 | negative selection | 3523134 | 25227401 | 25227424 | 12 | - | 26780180 | A375 | viability (Avana lentiGuide) | TCCCTTCTCAGGATTCCTACAGG | KRAS | ENSG00000133703 | -2.50081258974686 | [] | [] | -4 | hSpCas9 | negative selection | 3631788 | 25227386 | 25227409 | 12 | + | 26780180 | A375 | viability (Avana lentiGuide) | AATTACTACTTGCTTCCTGTAGG | KRAS | ENSG00000133703 | 7.6701561845403 | [] | [] | 6 | hSpCas9 | negative selection | 3631789 | 25227319 | 25227342 | 12 | - | 26780180 | A375 | viability (Avana lentiGuide) | AGAGGAGTACAGTGCAATGAGGG | KRAS | ENSG00000133703 | -0.138232151630188 | [] | [] | 0 | hSpCas9 | negative selection | 3631790 | 25245273 | 25245296 | 12 | - | 26780180 | A375 | viability (Avana lentiGuide) | CGAATATGATCCAACAATAGAGG | KRAS | ENSG00000133703 | 1.06130106742864 | [] | [] | 1 | hSpCas9 | negative selection | 3631791 | 25227337 | 25227360 | 12 | - | 26780180 | A375 | viability (Avana lentiGuide) | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 2.27118167389633 | [] | [] | 2 | hSpCas9 | negative selection | 3631792 | 25227298 | 25227321 | 12 | - | 26780180 | A375 | viability (Avana lentiGuide) | GGACCAGTACATGAGGACTGGGG | KRAS | ENSG00000133703 | 14.6888538277748 | [] | [] | 8 | hSpCas9 | negative selection | 3631793 | 25227401 | 25227424 | 12 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TCCCTTCTCAGGATTCCTACAGG | KRAS | ENSG00000133703 | -0.0401981790141209 | [5] | [6,3] | 0 | hSpCas9 | positive selection | 3740447 | 25227386 | 25227409 | 12 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | AATTACTACTTGCTTCCTGTAGG | KRAS | ENSG00000133703 | -0.6640056335556827 | [6] | [4,2] | -7 | hSpCas9 | positive selection | 3740448 | 25227319 | 25227342 | 12 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | AGAGGAGTACAGTGCAATGAGGG | KRAS | ENSG00000133703 | 0.46932975150844003 | [5] | [6,8] | 9 | hSpCas9 | positive selection | 3740449 | 25245273 | 25245296 | 12 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CGAATATGATCCAACAATAGAGG | KRAS | ENSG00000133703 | -0.8875097484053248 | [6] | [3,2] | -8 | hSpCas9 | positive selection | 3740450 | 25227337 | 25227360 | 12 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.17985114426466842 | [0] | [0,1] | 5 | hSpCas9 | positive selection | 3740451 | 25227298 | 25227321 | 12 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GGACCAGTACATGAGGACTGGGG | KRAS | ENSG00000133703 | -0.058147811434659885 | [4] | [3,4] | -1 | hSpCas9 | positive selection | 3740452 | 25227401 | 25227424 | 12 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TCCCTTCTCAGGATTCCTACAGG | KRAS | ENSG00000133703 | 0.27542940040047026 | [5] | [6,6] | 7 | hSpCas9 | positive selection | 3849054 | 25227386 | 25227409 | 12 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | AATTACTACTTGCTTCCTGTAGG | KRAS | ENSG00000133703 | -0.327076340397956 | [5] | [3,3] | -4 | hSpCas9 | positive selection | 3849055 | 25227319 | 25227342 | 12 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | AGAGGAGTACAGTGCAATGAGGG | KRAS | ENSG00000133703 | 0.9302828512328604 | [5] | [9,10] | 9 | hSpCas9 | positive selection | 3849056 | 25245273 | 25245296 | 12 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CGAATATGATCCAACAATAGAGG | KRAS | ENSG00000133703 | -0.005849270428138126 | [4] | [4,3] | 0 | hSpCas9 | positive selection | 3849057 | 25227337 | 25227360 | 12 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.4311201558111455 | [1] | [0,0] | -5 | hSpCas9 | positive selection | 3849058 | 25227298 | 25227321 | 12 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GGACCAGTACATGAGGACTGGGG | KRAS | ENSG00000133703 | 0.09398374063285868 | [5] | [3,5] | 2 | hSpCas9 | positive selection | 3849059 | 25215475 | 25215498 | 12 | - | 26780180 | A375 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | 1.75016529318427 | [] | [] | 9 | hSpCas9 | negative selection | 3955141 | 25227305 | 25227328 | 12 | - | 26780180 | A375 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 1.05226050472708 | [] | [] | 5 | hSpCas9 | negative selection | 3955142 | 25225720 | 25225743 | 12 | - | 26780180 | A375 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | 1.47968993739535 | [] | [] | 8 | hSpCas9 | negative selection | 3955143 | 25227337 | 25227360 | 12 | - | 26780180 | A375 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 1.39684138787806 | [] | [] | 7 | hSpCas9 | negative selection | 3955144 | 25209876 | 25209899 | 12 | + | 26780180 | A375 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.768116448428465 | [] | [] | 3 | hSpCas9 | negative selection | 3955145 | 25215475 | 25215498 | 12 | - | 26780180 | HT29 | viability (GeCKOv2 library) | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | 1.81643406472502 | [] | [] | 8 | hSpCas9 | negative selection | 4063107 | 25227305 | 25227328 | 12 | - | 26780180 | HT29 | viability (GeCKOv2 library) | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.808255909915405 | [] | [] | 3 | hSpCas9 | negative selection | 4063108 | 25225720 | 25225743 | 12 | - | 26780180 | HT29 | viability (GeCKOv2 library) | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | 0.887341618774554 | [] | [] | 4 | hSpCas9 | negative selection | 4063109 | 25227337 | 25227360 | 12 | - | 26780180 | HT29 | viability (GeCKOv2 library) | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.133354743668098 | [] | [] | 0 | hSpCas9 | negative selection | 4063110 | 25209876 | 25209899 | 12 | + | 26780180 | HT29 | viability (GeCKOv2 library) | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.269414606033542 | [] | [] | 0 | hSpCas9 | negative selection | 4063111 | 25227305 | 25227328 | 12 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiCRISPRv1) | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.6673498989395792 | [4] | [7,3] | 9 | hSpCas9 | positive selection | 4147638 | 25227305 | 25227328 | 12 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv1 lentiGuide) | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 1.1947968781509366 | [4] | [5,3,13,1] | 8 | hSpCas9 | positive selection | 4211660 | 25227337 | 25227360 | 12 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 1.206069727185501 | [3] | [6,5] | 9 | hSpCas9 | positive selection | 4279059 | 25227305 | 25227328 | 12 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.21161118400777906 | [2] | [2,1] | 4 | hSpCas9 | positive selection | 4279060 | 25209876 | 25209899 | 12 | + | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.03147735880835478 | [2] | [3,1] | 0 | hSpCas9 | positive selection | 4279061 | 25225720 | 25225743 | 12 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | 0.03337290488536334 | [3] | [2,1] | 0 | hSpCas9 | positive selection | 4343315 | 25215475 | 25215498 | 12 | - | 26780180 | A375 | resistance to vemurafenib (GeCKOv2 lentiGuide) | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.5675342283112181 | [2] | [1,0] | -8 | hSpCas9 | positive selection | 4343316 | 25225682 | 25225704 | 12 | + | 27760321 | OCIAML3 | viability | TTGTGTCTACTGTTCTAGAAGG | KRAS | ENSG00000133703 | -3.0328564401031217 | [63,84] | [11,0] | -9 | hSpCas9 | negative selection | 4412999 | 25227230 | 25227252 | 12 | - | 27760321 | OCIAML3 | viability | AGATATTCACCATTATAGGTGG | KRAS | ENSG00000133703 | -3.6529962146942783 | [8,21] | [0,0] | -9 | hSpCas9 | negative selection | 4413000 | 25227299 | 25227321 | 12 | - | 27760321 | OCIAML3 | viability | GGACCAGTACATGAGGACTGGG | KRAS | ENSG00000133703 | -0.773735787162444 | [569,439] | [270,174] | -6 | hSpCas9 | negative selection | 4413001 | 25227337 | 25227359 | 12 | - | 27760321 | OCIAML3 | viability | CTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.28924654691123575 | [366,348] | [152,328] | -3 | hSpCas9 | negative selection | 4413002 | 25227354 | 25227376 | 12 | + | 27760321 | OCIAML3 | viability | TCGAGAATATCCAAGAGACAGG | KRAS | ENSG00000133703 | -1.1722778559177107 | [130,124] | [17,78] | -8 | hSpCas9 | negative selection | 4413003 | 25225682 | 25225704 | 12 | + | 27760321 | OCIAML2 | viability | TTGTGTCTACTGTTCTAGAAGG | KRAS | ENSG00000133703 | -0.38484435055676647 | [63,84] | [48,43] | -4 | hSpCas9 | negative selection | 4496462 | 25227230 | 25227252 | 12 | - | 27760321 | OCIAML2 | viability | AGATATTCACCATTATAGGTGG | KRAS | ENSG00000133703 | -3.701741579959327 | [8,21] | [0,0] | -9 | hSpCas9 | negative selection | 4496463 | 25227299 | 25227321 | 12 | - | 27760321 | OCIAML2 | viability | GGACCAGTACATGAGGACTGGG | KRAS | ENSG00000133703 | 0.5075548601066703 | [569,439] | [475,708] | 7 | hSpCas9 | negative selection | 4496464 | 25227337 | 25227359 | 12 | - | 27760321 | OCIAML2 | viability | CTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.2464048307182444 | [366,348] | [327,364] | 3 | hSpCas9 | negative selection | 4496465 | 25227354 | 25227376 | 12 | + | 27760321 | OCIAML2 | viability | TCGAGAATATCCAAGAGACAGG | KRAS | ENSG00000133703 | -0.06874643539315461 | [130,124] | [97,99] | -1 | hSpCas9 | negative selection | 4496466 | 25225682 | 25225704 | 12 | + | 27760321 | MV411 | viability | TTGTGTCTACTGTTCTAGAAGG | KRAS | ENSG00000133703 | 0.8184529446595543 | [63,84] | [71,111] | 6 | hSpCas9 | negative selection | 4579925 | 25227230 | 25227252 | 12 | - | 27760321 | MV411 | viability | AGATATTCACCATTATAGGTGG | KRAS | ENSG00000133703 | -3.4079176457795963 | [8,21] | [0,0] | -9 | hSpCas9 | negative selection | 4579926 | 25227299 | 25227321 | 12 | - | 27760321 | MV411 | viability | GGACCAGTACATGAGGACTGGG | KRAS | ENSG00000133703 | -0.904584526736532 | [569,439] | [81,318] | -6 | hSpCas9 | negative selection | 4579927 | 25227337 | 25227359 | 12 | - | 27760321 | MV411 | viability | CTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.08933783882005181 | [366,348] | [137,348] | 0 | hSpCas9 | negative selection | 4579928 | 25227354 | 25227376 | 12 | + | 27760321 | MV411 | viability | TCGAGAATATCCAAGAGACAGG | KRAS | ENSG00000133703 | -0.9824304124835312 | [130,124] | [53,25] | -6 | hSpCas9 | negative selection | 4579929 | 25225682 | 25225704 | 12 | + | 27760321 | HL60 | viability | TTGTGTCTACTGTTCTAGAAGG | KRAS | ENSG00000133703 | -0.7845869880120309 | [63,84] | [30,40] | -7 | hSpCas9 | negative selection | 4663388 | 25227230 | 25227252 | 12 | - | 27760321 | HL60 | viability | AGATATTCACCATTATAGGTGG | KRAS | ENSG00000133703 | -3.715787807573733 | [8,21] | [0,0] | -9 | hSpCas9 | negative selection | 4663389 | 25227299 | 25227321 | 12 | - | 27760321 | HL60 | viability | GGACCAGTACATGAGGACTGGG | KRAS | ENSG00000133703 | -0.269000402705996 | [569,439] | [301,379] | -3 | hSpCas9 | negative selection | 4663390 | 25227337 | 25227359 | 12 | - | 27760321 | HL60 | viability | CTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.1307808390686689 | [366,348] | [256,387] | 1 | hSpCas9 | negative selection | 4663391 | 25227354 | 25227376 | 12 | + | 27760321 | HL60 | viability | TCGAGAATATCCAAGAGACAGG | KRAS | ENSG00000133703 | -0.07884601773071664 | [130,124] | [86,111] | -1 | hSpCas9 | negative selection | 4663392 | 25225682 | 25225704 | 12 | + | 27760321 | HT1080 | viability | TTGTGTCTACTGTTCTAGAAGG | KRAS | ENSG00000133703 | -1.4117101793406763 | [84,66] | [8,13] | -5 | hSpCas9 | negative selection | 4746851 | 25227230 | 25227252 | 12 | - | 27760321 | HT1080 | viability | AGATATTCACCATTATAGGTGG | KRAS | ENSG00000133703 | -2.95669589080409 | [21,16] | [0,0] | -7 | hSpCas9 | negative selection | 4746852 | 25227299 | 25227321 | 12 | - | 27760321 | HT1080 | viability | GGACCAGTACATGAGGACTGGG | KRAS | ENSG00000133703 | 1.0648073021869529 | [439,343] | [446,194] | 6 | hSpCas9 | negative selection | 4746853 | 25227337 | 25227359 | 12 | - | 27760321 | HT1080 | viability | CTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 1.5938458059224674 | [348,272] | [479,257] | 8 | hSpCas9 | negative selection | 4746854 | 25227354 | 25227376 | 12 | + | 27760321 | HT1080 | viability | TCGAGAATATCCAAGAGACAGG | KRAS | ENSG00000133703 | 1.7242352471132087 | [124,97] | [110,185] | 8 | hSpCas9 | negative selection | 4746855 | 25225682 | 25225704 | 12 | + | 27760321 | HT29 | viability after 7 days | TTGTGTCTACTGTTCTAGAAGG | KRAS | ENSG00000133703 | -0.962751727540053 | [84,66] | [38,64,44] | -8 | hSpCas9 | negative selection | 4830314 | 25227230 | 25227252 | 12 | - | 27760321 | HT29 | viability after 7 days | AGATATTCACCATTATAGGTGG | KRAS | ENSG00000133703 | -0.40882038195504755 | [21,16] | [0,0,50] | -6 | hSpCas9 | negative selection | 4830315 | 25227299 | 25227321 | 12 | - | 27760321 | HT29 | viability after 7 days | GGACCAGTACATGAGGACTGGG | KRAS | ENSG00000133703 | 0.2878268414327094 | [439,343] | [729,690,445] | 4 | hSpCas9 | negative selection | 4830316 | 25227337 | 25227359 | 12 | - | 27760321 | HT29 | viability after 7 days | CTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.2177303242905968 | [348,272] | [574,427,408] | 3 | hSpCas9 | negative selection | 4830317 | 25227354 | 25227376 | 12 | + | 27760321 | HT29 | viability after 7 days | TCGAGAATATCCAAGAGACAGG | KRAS | ENSG00000133703 | 0.20566299609073968 | [124,97] | [83,162,234] | 3 | hSpCas9 | negative selection | 4830318 | 25225682 | 25225704 | 12 | + | 27760321 | HT29 | viability after 25 days | TTGTGTCTACTGTTCTAGAAGG | KRAS | ENSG00000133703 | -0.3674943563271831 | [84,66] | [112,36,46] | -4 | hSpCas9 | negative selection | 4913777 | 25227230 | 25227252 | 12 | - | 27760321 | HT29 | viability after 25 days | AGATATTCACCATTATAGGTGG | KRAS | ENSG00000133703 | -4.476378155650614 | [21,16] | [0,0,0] | -9 | hSpCas9 | negative selection | 4913778 | 25227299 | 25227321 | 12 | - | 27760321 | HT29 | viability after 25 days | GGACCAGTACATGAGGACTGGG | KRAS | ENSG00000133703 | 0.16044973120131564 | [439,343] | [368,456,704] | 1 | hSpCas9 | negative selection | 4913779 | 25227337 | 25227359 | 12 | - | 27760321 | HT29 | viability after 25 days | CTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.26890941908414545 | [348,272] | [483,417,372] | 2 | hSpCas9 | negative selection | 4913780 | 25227354 | 25227376 | 12 | + | 27760321 | HT29 | viability after 25 days | TCGAGAATATCCAAGAGACAGG | KRAS | ENSG00000133703 | -0.5659080574616739 | [124,97] | [69,121,64] | -5 | hSpCas9 | negative selection | 4913781 | 25225682 | 25225704 | 12 | + | 27760321 | HT29 | viability after 22 days | TTGTGTCTACTGTTCTAGAAGG | KRAS | ENSG00000133703 | -0.769074479046369 | [84,66] | [99,48,3] | -6 | hSpCas9 | negative selection | 4997240 | 25227230 | 25227252 | 12 | - | 27760321 | HT29 | viability after 22 days | AGATATTCACCATTATAGGTGG | KRAS | ENSG00000133703 | -1.998122372894966 | [21,16] | [0,14,0] | -8 | hSpCas9 | negative selection | 4997241 | 25227299 | 25227321 | 12 | - | 27760321 | HT29 | viability after 22 days | GGACCAGTACATGAGGACTGGG | KRAS | ENSG00000133703 | 0.015250437326090854 | [439,343] | [251,424,704] | 0 | hSpCas9 | negative selection | 4997242 | 25227337 | 25227359 | 12 | - | 27760321 | HT29 | viability after 22 days | CTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.1884869320985561 | [348,272] | [356,433,439] | 2 | hSpCas9 | negative selection | 4997243 | 25227354 | 25227376 | 12 | + | 27760321 | HT29 | viability after 22 days | TCGAGAATATCCAAGAGACAGG | KRAS | ENSG00000133703 | -0.732466297703958 | [124,97] | [65,101,64] | -6 | hSpCas9 | negative selection | 4997244 | 25225682 | 25225704 | 12 | + | 27760321 | HT29 | viability after 19 days | TTGTGTCTACTGTTCTAGAAGG | KRAS | ENSG00000133703 | -1.2534066120561187 | [84,66] | [47,62,0] | -7 | hSpCas9 | negative selection | 5080703 | 25227230 | 25227252 | 12 | - | 27760321 | HT29 | viability after 19 days | AGATATTCACCATTATAGGTGG | KRAS | ENSG00000133703 | -4.47785673508666 | [21,16] | [0,0,0] | -9 | hSpCas9 | negative selection | 5080704 | 25227299 | 25227321 | 12 | - | 27760321 | HT29 | viability after 19 days | GGACCAGTACATGAGGACTGGG | KRAS | ENSG00000133703 | -0.17497297228630151 | [439,343] | [386,428,374] | -2 | hSpCas9 | negative selection | 5080705 | 25227337 | 25227359 | 12 | - | 27760321 | HT29 | viability after 19 days | CTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.7834326501266329 | [348,272] | [281,829,686] | 7 | hSpCas9 | negative selection | 5080706 | 25227354 | 25227376 | 12 | + | 27760321 | HT29 | viability after 19 days | TCGAGAATATCCAAGAGACAGG | KRAS | ENSG00000133703 | -1.0836041272677286 | [124,97] | [70,32,76] | -6 | hSpCas9 | negative selection | 5080707 | 25225682 | 25225704 | 12 | + | 27760321 | HT29 | viability after 16 days | TTGTGTCTACTGTTCTAGAAGG | KRAS | ENSG00000133703 | -0.08088766351523491 | [84,66] | [75,152,9] | -1 | hSpCas9 | negative selection | 5164166 | 25227230 | 25227252 | 12 | - | 27760321 | HT29 | viability after 16 days | AGATATTCACCATTATAGGTGG | KRAS | ENSG00000133703 | -1.4109704279896604 | [21,16] | [0,4,17] | -8 | hSpCas9 | negative selection | 5164167 | 25227299 | 25227321 | 12 | - | 27760321 | HT29 | viability after 16 days | GGACCAGTACATGAGGACTGGG | KRAS | ENSG00000133703 | 0.02219492290637365 | [439,343] | [534,316,495] | 0 | hSpCas9 | negative selection | 5164168 | 25227337 | 25227359 | 12 | - | 27760321 | HT29 | viability after 16 days | CTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.11931342839909112 | [348,272] | [517,460,165] | 1 | hSpCas9 | negative selection | 5164169 | 25227354 | 25227376 | 12 | + | 27760321 | HT29 | viability after 16 days | TCGAGAATATCCAAGAGACAGG | KRAS | ENSG00000133703 | -0.8516975373092754 | [124,97] | [111,48,50] | -6 | hSpCas9 | negative selection | 5164170 | 25225682 | 25225704 | 12 | + | 27760321 | HT29 | viability after 13 days | TTGTGTCTACTGTTCTAGAAGG | KRAS | ENSG00000133703 | 0.15314016701979183 | [84,66] | [84,190,22] | 1 | hSpCas9 | negative selection | 5247629 | 25227230 | 25227252 | 12 | - | 27760321 | HT29 | viability after 13 days | AGATATTCACCATTATAGGTGG | KRAS | ENSG00000133703 | -4.498679682109876 | [21,16] | [0,0,0] | -9 | hSpCas9 | negative selection | 5247630 | 25227299 | 25227321 | 12 | - | 27760321 | HT29 | viability after 13 days | GGACCAGTACATGAGGACTGGG | KRAS | ENSG00000133703 | 0.20251036956812749 | [439,343] | [561,520,488] | 2 | hSpCas9 | negative selection | 5247631 | 25227337 | 25227359 | 12 | - | 27760321 | HT29 | viability after 13 days | CTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.5528116916306126 | [348,272] | [774,549,277] | 7 | hSpCas9 | negative selection | 5247632 | 25227354 | 25227376 | 12 | + | 27760321 | HT29 | viability after 13 days | TCGAGAATATCCAAGAGACAGG | KRAS | ENSG00000133703 | -0.825113176295377 | [124,97] | [52,124,42] | -7 | hSpCas9 | negative selection | 5247633 | 25225682 | 25225704 | 12 | + | 27760321 | HT29 | viability after 10 days | TTGTGTCTACTGTTCTAGAAGG | KRAS | ENSG00000133703 | -0.6472683337828551 | [84,66] | [63,101,17] | -6 | hSpCas9 | negative selection | 5331092 | 25227230 | 25227252 | 12 | - | 27760321 | HT29 | viability after 10 days | AGATATTCACCATTATAGGTGG | KRAS | ENSG00000133703 | -4.60469098927022 | [21,16] | [0,0,0] | -9 | hSpCas9 | negative selection | 5331093 | 25227299 | 25227321 | 12 | - | 27760321 | HT29 | viability after 10 days | GGACCAGTACATGAGGACTGGG | KRAS | ENSG00000133703 | 0.30962054476481526 | [439,343] | [492,699,628] | 4 | hSpCas9 | negative selection | 5331094 | 25227337 | 25227359 | 12 | - | 27760321 | HT29 | viability after 10 days | CTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.15814911552184135 | [348,272] | [220,568,511] | 2 | hSpCas9 | negative selection | 5331095 | 25227354 | 25227376 | 12 | + | 27760321 | HT29 | viability after 10 days | TCGAGAATATCCAAGAGACAGG | KRAS | ENSG00000133703 | -0.7044866756078658 | [124,97] | [52,92,109] | -7 | hSpCas9 | negative selection | 5331096 | 25225682 | 25225704 | 12 | + | 27760321 | MOLM13 | viability | TTGTGTCTACTGTTCTAGAAGG | KRAS | ENSG00000133703 | -5.414704342108516 | [63,84] | [0,0] | -9 | hSpCas9 | negative selection | 5414555 | 25227230 | 25227252 | 12 | - | 27760321 | MOLM13 | viability | AGATATTCACCATTATAGGTGG | KRAS | ENSG00000133703 | -3.181860832952001 | [8,21] | [0,0] | -9 | hSpCas9 | negative selection | 5414556 | 25227299 | 25227321 | 12 | - | 27760321 | MOLM13 | viability | GGACCAGTACATGAGGACTGGG | KRAS | ENSG00000133703 | 0.668452042043385 | [569,439] | [374,512] | 4 | hSpCas9 | negative selection | 5414557 | 25227337 | 25227359 | 12 | - | 27760321 | MOLM13 | viability | CTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.4951551127111339 | [366,348] | [15,251] | -3 | hSpCas9 | negative selection | 5414558 | 25227354 | 25227376 | 12 | + | 27760321 | MOLM13 | viability | TCGAGAATATCCAAGAGACAGG | KRAS | ENSG00000133703 | -1.6299198493692657 | [130,124] | [4,38] | -7 | hSpCas9 | negative selection | 5414559 | 25250396 | 25250419 | 12 | - | 27661255 | K562 | viability | GGGCCGGCTGCCCCTCGGAGCGG | KRAS | ENSG00000133703 | -0.13731174626504167 | [705,910] | [678,503] | -5 | dCas9-KRAB | negative selection | 5489182 | 25227337 | 25227360 | 12 | - | 27260156 | BXPC3 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.38891506513941054 | [481] | [709,681,594,636] | 8 | hSpCas9 | negative selection | 5551519 | 25227305 | 25227328 | 12 | - | 27260156 | BXPC3 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.14135382749435932 | [239] | [243,321,235,306] | 3 | hSpCas9 | negative selection | 5551520 | 25209876 | 25209899 | 12 | + | 27260156 | BXPC3 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.2815066968473959 | [444] | [634,502,565,547] | 6 | hSpCas9 | negative selection | 5551521 | 25225720 | 25225743 | 12 | - | 27260156 | BXPC3 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.13701243661194984 | [497] | [447,532,485,415] | -3 | hSpCas9 | negative selection | 5615775 | 25215475 | 25215498 | 12 | - | 27260156 | BXPC3 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.3413104261373944 | [290] | [263,210,185,303] | -6 | hSpCas9 | negative selection | 5615776 | 25227337 | 25227360 | 12 | - | 27260156 | A673 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.16911630259731916 | [481] | [660,597,690,653] | 4 | hSpCas9 | negative selection | 5672770 | 25227305 | 25227328 | 12 | - | 27260156 | A673 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.08986064736424704 | [239] | [348,333,210,338] | 2 | hSpCas9 | negative selection | 5672771 | 25209876 | 25209899 | 12 | + | 27260156 | A673 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.20824260904064973 | [444] | [769,553,529,634] | 5 | hSpCas9 | negative selection | 5672772 | 25225720 | 25225743 | 12 | - | 27260156 | A673 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.24870134155197476 | [497] | [499,549,470,488] | -6 | hSpCas9 | negative selection | 5737026 | 25215475 | 25215498 | 12 | - | 27260156 | A673 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.6892449543351872 | [290] | [251,272,109,235] | -9 | hSpCas9 | negative selection | 5737027 | 25227337 | 25227360 | 12 | - | 27260156 | A375 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.20186671432440226 | [481] | [703,723,572,602] | 3 | hSpCas9 | negative selection | 5794021 | 25227305 | 25227328 | 12 | - | 27260156 | A375 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -0.22241713898390048 | [239] | [115,326,386,151] | -3 | hSpCas9 | negative selection | 5794022 | 25209876 | 25209899 | 12 | + | 27260156 | A375 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.4308923164548426 | [444] | [713,700,729,659] | 6 | hSpCas9 | negative selection | 5794023 | 25225720 | 25225743 | 12 | - | 27260156 | A375 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.24884001569709283 | [497] | [490,569,496,417] | -4 | hSpCas9 | negative selection | 5858277 | 25215475 | 25215498 | 12 | - | 27260156 | A375 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.2587260630218685 | [290] | [301,212,321,287] | -4 | hSpCas9 | negative selection | 5858278 | 25227337 | 25227360 | 12 | - | 27260156 | COLO741 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.6618669341421914 | [481] | [703,1351,851] | 9 | hSpCas9 | negative selection | 5915272 | 25227305 | 25227328 | 12 | - | 27260156 | COLO741 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.20682119842154134 | [239] | [360,352,347] | 4 | hSpCas9 | negative selection | 5915273 | 25209876 | 25209899 | 12 | + | 27260156 | COLO741 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.26155002014999307 | [444] | [728,675,644] | 5 | hSpCas9 | negative selection | 5915274 | 25225720 | 25225743 | 12 | - | 27260156 | COLO741 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.24438808029347225 | [497] | [586,540,489] | -5 | hSpCas9 | negative selection | 5979528 | 25215475 | 25215498 | 12 | - | 27260156 | COLO741 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.3804616536580262 | [290] | [244,337,270] | -7 | hSpCas9 | negative selection | 5979529 | 25227337 | 25227360 | 12 | - | 27260156 | CAL120 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.22146703607776605 | [481] | [1091,771,299] | 3 | hSpCas9 | negative selection | 6036523 | 25227305 | 25227328 | 12 | - | 27260156 | CAL120 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -0.1280446113128837 | [239] | [372,313,149] | -2 | hSpCas9 | negative selection | 6036524 | 25209876 | 25209899 | 12 | + | 27260156 | CAL120 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.6524055243267508 | [444] | [790,722,1080] | 8 | hSpCas9 | negative selection | 6036525 | 25225720 | 25225743 | 12 | - | 27260156 | CAL120 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.44025177394841253 | [497] | [480,455,436] | -6 | hSpCas9 | negative selection | 6100779 | 25215475 | 25215498 | 12 | - | 27260156 | CAL120 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.21195425428819226 | [290] | [475,264,222] | -3 | hSpCas9 | negative selection | 6100780 | 25227337 | 25227360 | 12 | - | 27260156 | CADOES1 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.10531885085333181 | [481] | [281,468,431,486] | -2 | hSpCas9 | negative selection | 6157774 | 25227305 | 25227328 | 12 | - | 27260156 | CADOES1 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.3240527972253898 | [239] | [230,326,176,386] | 5 | hSpCas9 | negative selection | 6157775 | 25209876 | 25209899 | 12 | + | 27260156 | CADOES1 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.33937967638141986 | [444] | [469,527,437,663] | 6 | hSpCas9 | negative selection | 6157776 | 25225720 | 25225743 | 12 | - | 27260156 | CADOES1 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.23399126693045766 | [497] | [421,282,398,473] | -4 | hSpCas9 | negative selection | 6222030 | 25215475 | 25215498 | 12 | - | 27260156 | CADOES1 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.23070706191500612 | [290] | [82,313,196,332] | -4 | hSpCas9 | negative selection | 6222031 | 25227337 | 25227360 | 12 | - | 27260156 | EWS502 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.2602467726297079 | [481] | [401,334,447,532] | -4 | hSpCas9 | negative selection | 6279025 | 25227305 | 25227328 | 12 | - | 27260156 | EWS502 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -0.3830973199352423 | [239] | [90,234,236,229] | -6 | hSpCas9 | negative selection | 6279026 | 25209876 | 25209899 | 12 | + | 27260156 | EWS502 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.32130312457956434 | [444] | [597,592,665,488] | 5 | hSpCas9 | negative selection | 6279027 | 25225720 | 25225743 | 12 | - | 27260156 | EWS502 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.876828343048217 | [497] | [251,350,260,284] | -8 | hSpCas9 | negative selection | 6343281 | 25215475 | 25215498 | 12 | - | 27260156 | EWS502 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -1.1833186960572943 | [290] | [139,153,106,139] | -9 | hSpCas9 | negative selection | 6343282 | 25227337 | 25227360 | 12 | - | 27260156 | EW8 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.04913604793962348 | [481] | [402,460,386,259] | -1 | hSpCas9 | negative selection | 6400276 | 25227305 | 25227328 | 12 | - | 27260156 | EW8 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -0.22102740256530407 | [239] | [225,146,133,171] | -4 | hSpCas9 | negative selection | 6400277 | 25209876 | 25209899 | 12 | + | 27260156 | EW8 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.14042354614608987 | [444] | [584,276,379,369] | 2 | hSpCas9 | negative selection | 6400278 | 25225720 | 25225743 | 12 | - | 27260156 | EW8 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.32238844645056364 | [497] | [357,357,264,322] | -6 | hSpCas9 | negative selection | 6464532 | 25215475 | 25215498 | 12 | - | 27260156 | EW8 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.7034363692068145 | [290] | [155,151,97,181] | -8 | hSpCas9 | negative selection | 6464533 | 25227337 | 25227360 | 12 | - | 27260156 | CORL105 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.14095301253170406 | [481] | [633,694,641,519] | 2 | hSpCas9 | negative selection | 6521527 | 25227305 | 25227328 | 12 | - | 27260156 | CORL105 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.09374982822215461 | [239] | [344,214,366,285] | 1 | hSpCas9 | negative selection | 6521528 | 25209876 | 25209899 | 12 | + | 27260156 | CORL105 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.15777757262626557 | [444] | [436,638,599,644] | 3 | hSpCas9 | negative selection | 6521529 | 25225720 | 25225743 | 12 | - | 27260156 | CORL105 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.2209338428170756 | [497] | [415,449,529,606] | -4 | hSpCas9 | negative selection | 6585783 | 25215475 | 25215498 | 12 | - | 27260156 | CORL105 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | 0.013141116817438125 | [290] | [374,354,330,312] | 0 | hSpCas9 | negative selection | 6585784 | 25227337 | 25227360 | 12 | - | 27260156 | HS294T | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.9640957648062642 | [481] | [77,73,102,135] | -8 | hSpCas9 | negative selection | 6642778 | 25227305 | 25227328 | 12 | - | 27260156 | HS294T | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -0.07040965441311009 | [239] | [16,18,105,246] | -1 | hSpCas9 | negative selection | 6642779 | 25209876 | 25209899 | 12 | + | 27260156 | HS294T | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | -0.159266464033942 | [444] | [104,121,138,275] | -2 | hSpCas9 | negative selection | 6642780 | 25225720 | 25225743 | 12 | - | 27260156 | HS294T | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.944755336921681 | [497] | [57,38,118,207] | -8 | hSpCas9 | negative selection | 6707034 | 25215475 | 25215498 | 12 | - | 27260156 | HS294T | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.8280871535000497 | [290] | [57,65,49,82] | -8 | hSpCas9 | negative selection | 6707035 | 25227337 | 25227360 | 12 | - | 27260156 | HCC44 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -2.823465337842956 | [481] | [53,84,82,82] | -9 | hSpCas9 | negative selection | 6764029 | 25227305 | 25227328 | 12 | - | 27260156 | HCC44 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -1.7391009538465287 | [239] | [73,92,98,59] | -9 | hSpCas9 | negative selection | 6764030 | 25209876 | 25209899 | 12 | + | 27260156 | HCC44 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | -0.0699636228285382 | [444] | [487,313,571,576] | -1 | hSpCas9 | negative selection | 6764031 | 25225720 | 25225743 | 12 | - | 27260156 | HCC44 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -1.7912893530842302 | [497] | [163,222,220,46] | -9 | hSpCas9 | negative selection | 6828285 | 25215475 | 25215498 | 12 | - | 27260156 | HCC44 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.3290222030623108 | [290] | [340,155,368,221] | -5 | hSpCas9 | negative selection | 6828286 | 25227337 | 25227360 | 12 | - | 27260156 | G402 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.07593341213512884 | [481] | [545,579,775,564] | 0 | hSpCas9 | negative selection | 6885280 | 25227305 | 25227328 | 12 | - | 27260156 | G402 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -0.35844681111589405 | [239] | [69,91,639,86] | -4 | hSpCas9 | negative selection | 6885281 | 25209876 | 25209899 | 12 | + | 27260156 | G402 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.241679733066561 | [444] | [471,654,798,616] | 3 | hSpCas9 | negative selection | 6885282 | 25225720 | 25225743 | 12 | - | 27260156 | G402 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.05359124324160551 | [497] | [472,450,897,497] | 0 | hSpCas9 | negative selection | 6949536 | 25215475 | 25215498 | 12 | - | 27260156 | G402 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.3537566316413826 | [290] | [445,199,372,118] | -4 | hSpCas9 | negative selection | 6949537 | 25227337 | 25227360 | 12 | - | 27260156 | L33 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.021481019039358687 | [481] | [530,198,332,352] | 0 | hSpCas9 | negative selection | 7006531 | 25227305 | 25227328 | 12 | - | 27260156 | L33 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.1903089580680447 | [239] | [330,83,166,291] | 4 | hSpCas9 | negative selection | 7006532 | 25209876 | 25209899 | 12 | + | 27260156 | L33 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.14662040757067446 | [444] | [435,158,418,481] | 3 | hSpCas9 | negative selection | 7006533 | 25225720 | 25225743 | 12 | - | 27260156 | L33 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.2922925098113677 | [497] | [404,131,261,481] | -6 | hSpCas9 | negative selection | 7070787 | 25215475 | 25215498 | 12 | - | 27260156 | L33 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.3754281008270334 | [290] | [174,98,107,308] | -7 | hSpCas9 | negative selection | 7070788 | 25227337 | 25227360 | 12 | - | 27260156 | K562 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.39414646818690635 | [481] | [168,255,711,165] | -5 | hSpCas9 | negative selection | 7127782 | 25227305 | 25227328 | 12 | - | 27260156 | K562 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.01321401912340614 | [239] | [137,264,310,148] | 0 | hSpCas9 | negative selection | 7127783 | 25209876 | 25209899 | 12 | + | 27260156 | K562 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.5597158375382262 | [444] | [803,619,405,522] | 7 | hSpCas9 | negative selection | 7127784 | 25225720 | 25225743 | 12 | - | 27260156 | K562 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.4367528339368544 | [497] | [432,311,263,305] | -5 | hSpCas9 | negative selection | 7192038 | 25215475 | 25215498 | 12 | - | 27260156 | K562 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | 0.012499368917100795 | [290] | [265,345,363,89] | 0 | hSpCas9 | negative selection | 7192039 | 25227337 | 25227360 | 12 | - | 27260156 | HT29 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.19495574471867966 | [481] | [738,726,685,550] | 4 | hSpCas9 | negative selection | 7249033 | 25227305 | 25227328 | 12 | - | 27260156 | HT29 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.004503368894010817 | [239] | [412,276,243,247] | 0 | hSpCas9 | negative selection | 7249034 | 25209876 | 25209899 | 12 | + | 27260156 | HT29 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.36195047170313804 | [444] | [658,950,669,534] | 7 | hSpCas9 | negative selection | 7249035 | 25225720 | 25225743 | 12 | - | 27260156 | HT29 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.2424491647568659 | [497] | [614,582,497,377] | -5 | hSpCas9 | negative selection | 7313289 | 25215475 | 25215498 | 12 | - | 27260156 | HT29 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.7104049531117876 | [290] | [269,339,159,119] | -8 | hSpCas9 | negative selection | 7313290 | 25227337 | 25227360 | 12 | - | 27260156 | MHHES1 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.019974713916380143 | [481] | [684,422,595,451] | 0 | hSpCas9 | negative selection | 7370284 | 25227305 | 25227328 | 12 | - | 27260156 | MHHES1 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -0.14788053374178056 | [239] | [317,310,121,235] | -3 | hSpCas9 | negative selection | 7370285 | 25209876 | 25209899 | 12 | + | 27260156 | MHHES1 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.5476331599262564 | [444] | [748,693,966,546] | 8 | hSpCas9 | negative selection | 7370286 | 25225720 | 25225743 | 12 | - | 27260156 | MHHES1 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.6303423714801806 | [497] | [240,520,438,264] | -8 | hSpCas9 | negative selection | 7434540 | 25215475 | 25215498 | 12 | - | 27260156 | MHHES1 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.4568067405085089 | [290] | [191,345,296,142] | -7 | hSpCas9 | negative selection | 7434541 | 25227337 | 25227360 | 12 | - | 27260156 | MEWO | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.5076409228630826 | [481] | [343,247,364] | -8 | hSpCas9 | negative selection | 7491535 | 25227305 | 25227328 | 12 | - | 27260156 | MEWO | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.23020254855865796 | [239] | [345,280,178] | 5 | hSpCas9 | negative selection | 7491536 | 25209876 | 25209899 | 12 | + | 27260156 | MEWO | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | -0.07114277884818011 | [444] | [299,423,445] | -1 | hSpCas9 | negative selection | 7491537 | 25225720 | 25225743 | 12 | - | 27260156 | MEWO | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | 0.004380409638671243 | [497] | [462,474,462] | 0 | hSpCas9 | negative selection | 7555791 | 25215475 | 25215498 | 12 | - | 27260156 | MEWO | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.7640536464762749 | [290] | [232,155,105] | -9 | hSpCas9 | negative selection | 7555792 | 25227337 | 25227360 | 12 | - | 27260156 | LNCAPCLONEFGC | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.16888853293945402 | [481] | [589,415,550,417] | 2 | hSpCas9 | negative selection | 7612786 | 25227305 | 25227328 | 12 | - | 27260156 | LNCAPCLONEFGC | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.10524862689301295 | [239] | [164,129,452,227] | 1 | hSpCas9 | negative selection | 7612787 | 25209876 | 25209899 | 12 | + | 27260156 | LNCAPCLONEFGC | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.40400390758195903 | [444] | [461,432,794,489] | 6 | hSpCas9 | negative selection | 7612788 | 25225720 | 25225743 | 12 | - | 27260156 | LNCAPCLONEFGC | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.3249807932182492 | [497] | [369,251,553,299] | -5 | hSpCas9 | negative selection | 7677042 | 25215475 | 25215498 | 12 | - | 27260156 | LNCAPCLONEFGC | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.15096053492748807 | [290] | [218,213,355,179] | -2 | hSpCas9 | negative selection | 7677043 | 25227337 | 25227360 | 12 | - | 27260156 | PANC0327 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -2.4444578152435037 | [481] | [104,38,127,49] | -9 | hSpCas9 | negative selection | 7734037 | 25227305 | 25227328 | 12 | - | 27260156 | PANC0327 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -2.179468398713623 | [239] | [78,14,48,51] | -9 | hSpCas9 | negative selection | 7734038 | 25209876 | 25209899 | 12 | + | 27260156 | PANC0327 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.44575353846926197 | [444] | [291,413,932,510] | 6 | hSpCas9 | negative selection | 7734039 | 25225720 | 25225743 | 12 | - | 27260156 | PANC0327 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -1.4532256686074743 | [497] | [154,174,196,116] | -9 | hSpCas9 | negative selection | 7798293 | 25215475 | 25215498 | 12 | - | 27260156 | PANC0327 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.34986201913952 | [290] | [258,86,297,186] | -5 | hSpCas9 | negative selection | 7798294 | 25227337 | 25227360 | 12 | - | 27260156 | NCIH2009 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -2.055087304664114 | [481] | [229,233,33] | -9 | hSpCas9 | negative selection | 7855288 | 25227305 | 25227328 | 12 | - | 27260156 | NCIH2009 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -1.116092795346386 | [239] | [173,189,102] | -8 | hSpCas9 | negative selection | 7855289 | 25209876 | 25209899 | 12 | + | 27260156 | NCIH2009 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | -0.4038829076817513 | [444] | [576,476,375] | -5 | hSpCas9 | negative selection | 7855290 | 25225720 | 25225743 | 12 | - | 27260156 | NCIH2009 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -2.307222527937521 | [497] | [203,142,86] | -9 | hSpCas9 | negative selection | 7919544 | 25215475 | 25215498 | 12 | - | 27260156 | NCIH2009 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.37796124635712414 | [290] | [507,237,231] | -5 | hSpCas9 | negative selection | 7919545 | 25227337 | 25227360 | 12 | - | 27260156 | NCIH1373 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -3.100549801024528 | [481] | [49,106,37,12] | -9 | hSpCas9 | negative selection | 7976539 | 25227305 | 25227328 | 12 | - | 27260156 | NCIH1373 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -1.1382920752483263 | [239] | [99,162,102,29] | -8 | hSpCas9 | negative selection | 7976540 | 25209876 | 25209899 | 12 | + | 27260156 | NCIH1373 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.39720369985775766 | [444] | [561,723,485,221] | 4 | hSpCas9 | negative selection | 7976541 | 25225720 | 25225743 | 12 | - | 27260156 | NCIH1373 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -2.2992965486003776 | [497] | [208,72,76,29] | -9 | hSpCas9 | negative selection | 8040795 | 25215475 | 25215498 | 12 | - | 27260156 | NCIH1373 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.05363722435580953 | [290] | [562,254,148,88] | 0 | hSpCas9 | negative selection | 8040796 | 25227337 | 25227360 | 12 | - | 27260156 | PATU8902 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -4.861725302924016 | [481] | [64,3,2,24] | -9 | hSpCas9 | negative selection | 8097790 | 25227305 | 25227328 | 12 | - | 27260156 | PATU8902 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -2.023595131353358 | [239] | [23,160,8,163] | -9 | hSpCas9 | negative selection | 8097791 | 25209876 | 25209899 | 12 | + | 27260156 | PATU8902 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | -1.8626386855354973 | [444] | [111,120,247,180] | -9 | hSpCas9 | negative selection | 8097792 | 25225720 | 25225743 | 12 | - | 27260156 | PATU8902 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -2.2558837171634196 | [497] | [425,30,52,81] | -9 | hSpCas9 | negative selection | 8162046 | 25215475 | 25215498 | 12 | - | 27260156 | PATU8902 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.21565261845046202 | [290] | [176,582,67,680] | -2 | hSpCas9 | negative selection | 8162047 | 25227337 | 25227360 | 12 | - | 27260156 | PANC1 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -4.279655434472543 | [481] | [14,14,26,25] | -9 | hSpCas9 | negative selection | 8219041 | 25227305 | 25227328 | 12 | - | 27260156 | PANC1 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -1.9550467967674419 | [239] | [42,47,59,58] | -9 | hSpCas9 | negative selection | 8219042 | 25209876 | 25209899 | 12 | + | 27260156 | PANC1 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | -0.26477511182140107 | [444] | [303,554,291,186] | -4 | hSpCas9 | negative selection | 8219043 | 25225720 | 25225743 | 12 | - | 27260156 | PANC1 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -1.5756484622107991 | [497] | [186,282,63,75] | -9 | hSpCas9 | negative selection | 8283297 | 25215475 | 25215498 | 12 | - | 27260156 | PANC1 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.763722263095019 | [290] | [162,169,219,53] | -8 | hSpCas9 | negative selection | 8283298 | 25227337 | 25227360 | 12 | - | 27260156 | PANC0813 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -1.7964915226624438 | [481] | [127,86,184,243] | -9 | hSpCas9 | negative selection | 8340292 | 25227305 | 25227328 | 12 | - | 27260156 | PANC0813 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -1.8272162084551586 | [239] | [66,49,107,90] | -9 | hSpCas9 | negative selection | 8340293 | 25209876 | 25209899 | 12 | + | 27260156 | PANC0813 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.07071832918377191 | [444] | [552,437,673,531] | 1 | hSpCas9 | negative selection | 8340294 | 25225720 | 25225743 | 12 | - | 27260156 | PANC0813 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -1.7305505049702146 | [497] | [134,139,260,165] | -9 | hSpCas9 | negative selection | 8404548 | 25215475 | 25215498 | 12 | - | 27260156 | PANC0813 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.12182013116310242 | [290] | [374,366,305,218] | -2 | hSpCas9 | negative selection | 8404549 | 25227337 | 25227360 | 12 | - | 27260156 | RDES | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.2744759492886526 | [481] | [412,412,500,515] | -5 | hSpCas9 | negative selection | 8461543 | 25227305 | 25227328 | 12 | - | 27260156 | RDES | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -0.331040415720842 | [239] | [166,228,196,299] | -5 | hSpCas9 | negative selection | 8461544 | 25209876 | 25209899 | 12 | + | 27260156 | RDES | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.20796920973446675 | [444] | [492,504,682,717] | 3 | hSpCas9 | negative selection | 8461545 | 25225720 | 25225743 | 12 | - | 27260156 | RDES | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.5630164838940988 | [497] | [325,330,316,615] | -7 | hSpCas9 | negative selection | 8525799 | 25215475 | 25215498 | 12 | - | 27260156 | RDES | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.4676539927756326 | [290] | [222,195,188,379] | -7 | hSpCas9 | negative selection | 8525800 | 25227337 | 25227360 | 12 | - | 27260156 | PC3 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.07247241056076678 | [481] | [345,330,880,642] | 1 | hSpCas9 | negative selection | 8582794 | 25227305 | 25227328 | 12 | - | 27260156 | PC3 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.023611316653819436 | [239] | [179,234,511,146] | 0 | hSpCas9 | negative selection | 8582795 | 25209876 | 25209899 | 12 | + | 27260156 | PC3 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.22388735695735268 | [444] | [327,446,905,581] | 5 | hSpCas9 | negative selection | 8582796 | 25225720 | 25225743 | 12 | - | 27260156 | PC3 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.09557898587658448 | [497] | [262,494,817,464] | -2 | hSpCas9 | negative selection | 8647050 | 25215475 | 25215498 | 12 | - | 27260156 | PC3 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | 0.3749280455349318 | [290] | [67,149,1614,288] | 7 | hSpCas9 | negative selection | 8647051 | 25227337 | 25227360 | 12 | - | 27260156 | PATU8988T | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -1.9466597550883846 | [481] | [63,231,89,106] | -9 | hSpCas9 | negative selection | 8704045 | 25227305 | 25227328 | 12 | - | 27260156 | PATU8988T | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -1.7118684746166533 | [239] | [113,33,88,39] | -9 | hSpCas9 | negative selection | 8704046 | 25209876 | 25209899 | 12 | + | 27260156 | PATU8988T | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | -0.2530461182431332 | [444] | [457,456,293,233] | -4 | hSpCas9 | negative selection | 8704047 | 25225720 | 25225743 | 12 | - | 27260156 | PATU8988T | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -1.0444316953280426 | [497] | [247,181,234,265] | -9 | hSpCas9 | negative selection | 8768301 | 25215475 | 25215498 | 12 | - | 27260156 | PATU8988T | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.12405311034945798 | [290] | [222,148,350,300] | -2 | hSpCas9 | negative selection | 8768302 | 25227337 | 25227360 | 12 | - | 27260156 | T47D | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.09725036342402335 | [481] | [591,542,470,491] | -2 | hSpCas9 | negative selection | 8825296 | 25227305 | 25227328 | 12 | - | 27260156 | T47D | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.08523892680276857 | [239] | [326,352,266,232] | 1 | hSpCas9 | negative selection | 8825297 | 25209876 | 25209899 | 12 | + | 27260156 | T47D | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.24296901900518886 | [444] | [626,665,612,540] | 5 | hSpCas9 | negative selection | 8825298 | 25225720 | 25225743 | 12 | - | 27260156 | T47D | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.4140253505539244 | [497] | [406,364,496,478] | -7 | hSpCas9 | negative selection | 8889552 | 25215475 | 25215498 | 12 | - | 27260156 | T47D | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.2289271698407479 | [290] | [209,286,319,340] | -5 | hSpCas9 | negative selection | 8889553 | 25227337 | 25227360 | 12 | - | 27260156 | SU8686 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -2.5543656584798837 | [481] | [42,116,61,105] | -9 | hSpCas9 | negative selection | 8946547 | 25227305 | 25227328 | 12 | - | 27260156 | SU8686 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -1.8003686173722746 | [239] | [48,60,71,98] | -9 | hSpCas9 | negative selection | 8946548 | 25209876 | 25209899 | 12 | + | 27260156 | SU8686 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.06186029341855447 | [444] | [455,396,420,593] | 1 | hSpCas9 | negative selection | 8946549 | 25225720 | 25225743 | 12 | - | 27260156 | SU8686 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -2.2959479831363536 | [497] | [95,74,135,98] | -9 | hSpCas9 | negative selection | 9010803 | 25215475 | 25215498 | 12 | - | 27260156 | SU8686 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.4443121109631135 | [290] | [273,188,191,181] | -6 | hSpCas9 | negative selection | 9010804 | 25227337 | 25227360 | 12 | - | 27260156 | SKES1 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.014852762092818432 | [481] | [516,360,559,487] | 0 | hSpCas9 | negative selection | 9067798 | 25227305 | 25227328 | 12 | - | 27260156 | SKES1 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -0.3394018068200553 | [239] | [161,230,201,163] | -6 | hSpCas9 | negative selection | 9067799 | 25209876 | 25209899 | 12 | + | 27260156 | SKES1 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.29747508569360465 | [444] | [587,546,574,479] | 6 | hSpCas9 | negative selection | 9067800 | 25225720 | 25225743 | 12 | - | 27260156 | SKES1 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.009187054382694418 | [497] | [561,518,450,454] | 0 | hSpCas9 | negative selection | 9132054 | 25215475 | 25215498 | 12 | - | 27260156 | SKES1 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.8054933935036294 | [290] | [172,183,173,137] | -9 | hSpCas9 | negative selection | 9132055 | 25227337 | 25227360 | 12 | - | 27260156 | TOV112D | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | 0.1176064891720762 | [481] | [551,819,439,361] | 2 | hSpCas9 | negative selection | 9189049 | 25227305 | 25227328 | 12 | - | 27260156 | TOV112D | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -0.018793653204842276 | [239] | [270,237,180,260] | 0 | hSpCas9 | negative selection | 9189050 | 25209876 | 25209899 | 12 | + | 27260156 | TOV112D | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.231100823744809 | [444] | [551,793,410,406] | 4 | hSpCas9 | negative selection | 9189051 | 25225720 | 25225743 | 12 | - | 27260156 | TOV112D | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.20490612452453716 | [497] | [506,461,353,420] | -4 | hSpCas9 | negative selection | 9253305 | 25215475 | 25215498 | 12 | - | 27260156 | TOV112D | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | 0.08019620057369237 | [290] | [178,684,365,89] | 1 | hSpCas9 | negative selection | 9253306 | 25227337 | 25227360 | 12 | - | 27260156 | TC71 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.01178243055142348 | [481] | [489,457,466,644] | 0 | hSpCas9 | negative selection | 9310300 | 25227305 | 25227328 | 12 | - | 27260156 | TC71 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -0.2379927759461773 | [239] | [196,234,290,142] | -6 | hSpCas9 | negative selection | 9310301 | 25209876 | 25209899 | 12 | + | 27260156 | TC71 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | -0.01592156772537237 | [444] | [549,439,363,538] | 0 | hSpCas9 | negative selection | 9310302 | 25225720 | 25225743 | 12 | - | 27260156 | TC71 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.20355942545618771 | [497] | [358,489,531,473] | -5 | hSpCas9 | negative selection | 9374556 | 25215475 | 25215498 | 12 | - | 27260156 | TC71 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.3668241460891891 | [290] | [194,234,273,264] | -7 | hSpCas9 | negative selection | 9374557 | 25227337 | 25227360 | 12 | - | 27260156 | TC32 | viability | TCTCGACACAGCAGGTCAAGAGG | KRAS | ENSG00000133703 | -0.14981454258605764 | [481] | [420,285,519,447] | -3 | hSpCas9 | negative selection | 9431551 | 25227305 | 25227328 | 12 | - | 27260156 | TC32 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -0.453426343560295 | [239] | [160,130,273,111] | -7 | hSpCas9 | negative selection | 9431552 | 25209876 | 25209899 | 12 | + | 27260156 | TC32 | viability | TTCTCGAACTAATGTATAGAAGG | KRAS | ENSG00000133703 | 0.11766500279350295 | [444] | [414,438,486,460] | 2 | hSpCas9 | negative selection | 9431553 | 25225720 | 25225743 | 12 | - | 27260156 | TC32 | viability | GATGTACCTATGGTCCTAGTAGG | KRAS | ENSG00000133703 | -0.5092411309819211 | [497] | [262,203,580,349] | -7 | hSpCas9 | negative selection | 9495807 | 25215475 | 25215498 | 12 | - | 27260156 | TC32 | viability | AGCAAAGAAGAAAAGACTCCTGG | KRAS | ENSG00000133703 | -0.5481469506621287 | [290] | [191,167,234,153] | -8 | hSpCas9 | negative selection | 9495808 | 25227295 | 25227318 | 12 | - | 28162770 | P31FUJ | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | 0.3741028491874548 | [173] | [264] | 4 | hSpCas9 | negative selection | 10181146 | 25245310 | 25245333 | 12 | + | 28162770 | P31FUJ | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | 0.01833011236312343 | [141] | [168] | 0 | hSpCas9 | negative selection | 10181147 | 25245341 | 25245364 | 12 | - | 28162770 | P31FUJ | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | 0.8005349794597341 | [384] | [787] | 8 | hSpCas9 | negative selection | 10181148 | 25227320 | 25227343 | 12 | - | 28162770 | P31FUJ | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | 0.4646350255651902 | [221] | [359] | 5 | hSpCas9 | negative selection | 10181149 | 25225730 | 25225753 | 12 | - | 28162770 | P31FUJ | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | 0.8253875592576281 | [327] | [682] | 8 | hSpCas9 | negative selection | 10181150 | 25225670 | 25225693 | 12 | - | 28162770 | P31FUJ | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | 0.9700940412962722 | [148] | [342] | 9 | hSpCas9 | negative selection | 10181151 | 25227305 | 25227328 | 12 | - | 28162770 | P31FUJ | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.4808936104289805 | [174] | [286] | 5 | hSpCas9 | negative selection | 10181152 | 25227345 | 25227368 | 12 | - | 28162770 | P31FUJ | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | 0.4783374023839224 | [495] | [811] | 5 | hSpCas9 | negative selection | 10181153 | 25227295 | 25227318 | 12 | - | 28162770 | TF1 | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | NaN | [NaN] | [78] | 1 | hSpCas9 | negative selection | 10350512 | 25245310 | 25245333 | 12 | + | 28162770 | TF1 | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | NaN | [NaN] | [270] | 1 | hSpCas9 | negative selection | 10350513 | 25245341 | 25245364 | 12 | - | 28162770 | TF1 | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | NaN | [NaN] | [9] | 1 | hSpCas9 | negative selection | 10350514 | 25227320 | 25227343 | 12 | - | 28162770 | TF1 | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | NaN | [NaN] | [36] | 1 | hSpCas9 | negative selection | 10350515 | 25225730 | 25225753 | 12 | - | 28162770 | TF1 | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | NaN | [NaN] | [48] | 1 | hSpCas9 | negative selection | 10350516 | 25225670 | 25225693 | 12 | - | 28162770 | TF1 | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | NaN | [NaN] | [38] | 1 | hSpCas9 | negative selection | 10350517 | 25227305 | 25227328 | 12 | - | 28162770 | TF1 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | NaN | [NaN] | [41] | 1 | hSpCas9 | negative selection | 10350518 | 25227345 | 25227368 | 12 | - | 28162770 | TF1 | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | NaN | [NaN] | [592] | 1 | hSpCas9 | negative selection | 10350519 | 25227295 | 25227318 | 12 | - | 28162770 | SKM1 | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | -2.217930374353145 | [49] | [18] | -8 | hSpCas9 | negative selection | 10519878 | 25245310 | 25245333 | 12 | + | 28162770 | SKM1 | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | -0.32450203855118853 | [33] | [47] | -3 | hSpCas9 | negative selection | 10519879 | 25245341 | 25245364 | 12 | - | 28162770 | SKM1 | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | -4.384937892413163 | [129] | [10] | -9 | hSpCas9 | negative selection | 10519880 | 25227320 | 25227343 | 12 | - | 28162770 | SKM1 | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | -4.540819945477953 | [78] | [5] | -9 | hSpCas9 | negative selection | 10519881 | 25225730 | 25225753 | 12 | - | 28162770 | SKM1 | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | -4.016379743188857 | [118] | [12] | -9 | hSpCas9 | negative selection | 10519882 | 25225670 | 25225693 | 12 | - | 28162770 | SKM1 | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | -3.034995421356204 | [50] | [10] | -9 | hSpCas9 | negative selection | 10519883 | 25227305 | 25227328 | 12 | - | 28162770 | SKM1 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -4.366322214245816 | [34] | [2] | -9 | hSpCas9 | negative selection | 10519884 | 25227345 | 25227368 | 12 | - | 28162770 | SKM1 | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | -1.2294260131909742 | [125] | [94] | -7 | hSpCas9 | negative selection | 10519885 | 25227295 | 25227318 | 12 | - | 28162770 | SKM1 | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | -2.217930374353145 | [49] | [18] | -8 | hSpCas9 | negative selection | 10689244 | 25245310 | 25245333 | 12 | + | 28162770 | SKM1 | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | -0.32450203855118853 | [33] | [47] | -3 | hSpCas9 | negative selection | 10689245 | 25245341 | 25245364 | 12 | - | 28162770 | SKM1 | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | -4.384937892413163 | [129] | [10] | -9 | hSpCas9 | negative selection | 10689246 | 25227320 | 25227343 | 12 | - | 28162770 | SKM1 | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | -4.540819945477953 | [78] | [5] | -9 | hSpCas9 | negative selection | 10689247 | 25225730 | 25225753 | 12 | - | 28162770 | SKM1 | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | -4.016379743188857 | [118] | [12] | -9 | hSpCas9 | negative selection | 10689248 | 25225670 | 25225693 | 12 | - | 28162770 | SKM1 | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | -3.034995421356204 | [50] | [10] | -9 | hSpCas9 | negative selection | 10689249 | 25227305 | 25227328 | 12 | - | 28162770 | SKM1 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -4.366322214245816 | [34] | [2] | -9 | hSpCas9 | negative selection | 10689250 | 25227345 | 25227368 | 12 | - | 28162770 | SKM1 | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | -1.2294260131909742 | [125] | [94] | -7 | hSpCas9 | negative selection | 10689251 | 25227295 | 25227318 | 12 | - | 28162770 | PL21 | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | -0.7366665590234858 | [133] | [34] | -5 | hSpCas9 | negative selection | 10858610 | 25245310 | 25245333 | 12 | + | 28162770 | PL21 | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | 0.007494536546924557 | [79] | [34] | 0 | hSpCas9 | negative selection | 10858611 | 25245341 | 25245364 | 12 | - | 28162770 | PL21 | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | -7.623227625556916 | [452] | [0] | -9 | hSpCas9 | negative selection | 10858612 | 25227320 | 25227343 | 12 | - | 28162770 | PL21 | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | -3.057876716577849 | [286] | [14] | -9 | hSpCas9 | negative selection | 10858613 | 25225730 | 25225753 | 12 | - | 28162770 | PL21 | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | -2.5891813847380223 | [317] | [22] | -9 | hSpCas9 | negative selection | 10858614 | 25225670 | 25225693 | 12 | - | 28162770 | PL21 | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | -1.7028986556235919 | [186] | [24] | -8 | hSpCas9 | negative selection | 10858615 | 25227305 | 25227328 | 12 | - | 28162770 | PL21 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.11267677323898062 | [67] | [31] | 1 | hSpCas9 | negative selection | 10858616 | 25227345 | 25227368 | 12 | - | 28162770 | PL21 | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | 0.6609227039897463 | [387] | [266] | 6 | hSpCas9 | negative selection | 10858617 | 25227295 | 25227318 | 12 | - | 28162770 | P31FUJ | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | 0.3741028491874548 | [173] | [264] | 4 | hSpCas9 | negative selection | 11027976 | 25245310 | 25245333 | 12 | + | 28162770 | P31FUJ | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | 0.01833011236312343 | [141] | [168] | 0 | hSpCas9 | negative selection | 11027977 | 25245341 | 25245364 | 12 | - | 28162770 | P31FUJ | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | 0.8005349794597341 | [384] | [787] | 8 | hSpCas9 | negative selection | 11027978 | 25227320 | 25227343 | 12 | - | 28162770 | P31FUJ | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | 0.4646350255651902 | [221] | [359] | 5 | hSpCas9 | negative selection | 11027979 | 25225730 | 25225753 | 12 | - | 28162770 | P31FUJ | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | 0.8253875592576281 | [327] | [682] | 8 | hSpCas9 | negative selection | 11027980 | 25225670 | 25225693 | 12 | - | 28162770 | P31FUJ | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | 0.9700940412962722 | [148] | [342] | 9 | hSpCas9 | negative selection | 11027981 | 25227305 | 25227328 | 12 | - | 28162770 | P31FUJ | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.4808936104289805 | [174] | [286] | 5 | hSpCas9 | negative selection | 11027982 | 25227345 | 25227368 | 12 | - | 28162770 | P31FUJ | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | 0.4783374023839224 | [495] | [811] | 5 | hSpCas9 | negative selection | 11027983 | 25227295 | 25227318 | 12 | - | 28162770 | OCIAML5 | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | -1.3301138676686413 | [77] | [55] | -6 | hSpCas9 | negative selection | 11197342 | 25245310 | 25245333 | 12 | + | 28162770 | OCIAML5 | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | -0.2624426927729779 | [102] | [154] | -2 | hSpCas9 | negative selection | 11197343 | 25245341 | 25245364 | 12 | - | 28162770 | OCIAML5 | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | -0.7718962221800137 | [174] | [184] | -5 | hSpCas9 | negative selection | 11197344 | 25227320 | 25227343 | 12 | - | 28162770 | OCIAML5 | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | 0.582217017359491 | [120] | [326] | 5 | hSpCas9 | negative selection | 11197345 | 25225730 | 25225753 | 12 | - | 28162770 | OCIAML5 | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | -0.28140245319540935 | [168] | [250] | -2 | hSpCas9 | negative selection | 11197346 | 25225670 | 25225693 | 12 | - | 28162770 | OCIAML5 | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | 0.19586790619970507 | [73] | [152] | 1 | hSpCas9 | negative selection | 11197347 | 25227305 | 25227328 | 12 | - | 28162770 | OCIAML5 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 1.020058606583845 | [55] | [204] | 8 | hSpCas9 | negative selection | 11197348 | 25227345 | 25227368 | 12 | - | 28162770 | OCIAML5 | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | 1.014994597317875 | [212] | [776] | 8 | hSpCas9 | negative selection | 11197349 | 25227295 | 25227318 | 12 | - | 28162770 | EOL1 | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | -0.7030066058750896 | [274] | [88] | -5 | hSpCas9 | negative selection | 11366708 | 25245310 | 25245333 | 12 | + | 28162770 | EOL1 | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | -0.026542627948518804 | [115] | [59] | 0 | hSpCas9 | negative selection | 11366709 | 25245341 | 25245364 | 12 | - | 28162770 | EOL1 | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | -1.9885063154303437 | [820] | [108] | -8 | hSpCas9 | negative selection | 11366710 | 25227320 | 25227343 | 12 | - | 28162770 | EOL1 | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | -0.8321810774171017 | [391] | [115] | -5 | hSpCas9 | negative selection | 11366711 | 25225730 | 25225753 | 12 | - | 28162770 | EOL1 | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | -0.974168892592284 | [659] | [176] | -6 | hSpCas9 | negative selection | 11366712 | 25225670 | 25225693 | 12 | - | 28162770 | EOL1 | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | 0.3995673756776108 | [317] | [220] | 3 | hSpCas9 | negative selection | 11366713 | 25227305 | 25227328 | 12 | - | 28162770 | EOL1 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -0.223350923541779 | [194] | [87] | -2 | hSpCas9 | negative selection | 11366714 | 25227345 | 25227368 | 12 | - | 28162770 | EOL1 | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | 1.3381153827539238 | [490] | [653] | 9 | hSpCas9 | negative selection | 11366715 | 25227295 | 25227318 | 12 | - | 28162770 | MOLM13 | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | 0.873528182821173 | [230] | [305] | 6 | hSpCas9 | negative selection | 11536074 | 25245310 | 25245333 | 12 | + | 28162770 | MOLM13 | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | 1.4288952499287153 | [149] | [291] | 9 | hSpCas9 | negative selection | 11536075 | 25245341 | 25245364 | 12 | - | 28162770 | MOLM13 | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | -0.5670704568092212 | [542] | [264] | -3 | hSpCas9 | negative selection | 11536076 | 25227320 | 25227343 | 12 | - | 28162770 | MOLM13 | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | 0.48820936592417463 | [422] | [428] | 3 | hSpCas9 | negative selection | 11536077 | 25225730 | 25225753 | 12 | - | 28162770 | MOLM13 | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | 0.3361307933737011 | [400] | [365] | 2 | hSpCas9 | negative selection | 11536078 | 25225670 | 25225693 | 12 | - | 28162770 | MOLM13 | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | 0.6370471960286956 | [208] | [234] | 5 | hSpCas9 | negative selection | 11536079 | 25227305 | 25227328 | 12 | - | 28162770 | MOLM13 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.3657089867381005 | [116] | [108] | 2 | hSpCas9 | negative selection | 11536080 | 25227345 | 25227368 | 12 | - | 28162770 | MOLM13 | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | 0.6260957844485335 | [672] | [750] | 5 | hSpCas9 | negative selection | 11536081 | 25227295 | 25227318 | 12 | - | 28162770 | HEL | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | -0.06352996494293278 | [185] | [113] | 0 | hSpCas9 | negative selection | 11705440 | 25245310 | 25245333 | 12 | + | 28162770 | HEL | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | 1.2066397171936833 | [160] | [237] | 9 | hSpCas9 | negative selection | 11705441 | 25245341 | 25245364 | 12 | - | 28162770 | HEL | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | 0.07832370868328642 | [487] | [329] | 0 | hSpCas9 | negative selection | 11705442 | 25227320 | 25227343 | 12 | - | 28162770 | HEL | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | 0.9909782040035664 | [325] | [414] | 8 | hSpCas9 | negative selection | 11705443 | 25225730 | 25225753 | 12 | - | 28162770 | HEL | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | 0.5662406945263134 | [425] | [403] | 5 | hSpCas9 | negative selection | 11705444 | 25225670 | 25225693 | 12 | - | 28162770 | HEL | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | 0.12903501444902277 | [236] | [165] | 1 | hSpCas9 | negative selection | 11705445 | 25227305 | 25227328 | 12 | - | 28162770 | HEL | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -1.579653589336091 | [139] | [29] | -7 | hSpCas9 | negative selection | 11705446 | 25227345 | 25227368 | 12 | - | 28162770 | HEL | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | 0.6038659403560669 | [488] | [475] | 5 | hSpCas9 | negative selection | 11705447 | 25227295 | 25227318 | 12 | - | 28162770 | MV411 | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | -0.713391851936547 | [108] | [55] | -5 | hSpCas9 | negative selection | 11874806 | 25245310 | 25245333 | 12 | + | 28162770 | MV411 | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | 0.6485358591037454 | [155] | [205] | 6 | hSpCas9 | negative selection | 11874807 | 25245341 | 25245364 | 12 | - | 28162770 | MV411 | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | -0.900461144329538 | [389] | [175] | -6 | hSpCas9 | negative selection | 11874808 | 25227320 | 25227343 | 12 | - | 28162770 | MV411 | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | 0.3994406442278253 | [206] | [229] | 3 | hSpCas9 | negative selection | 11874809 | 25225730 | 25225753 | 12 | - | 28162770 | MV411 | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | 0.16095803005730713 | [274] | [258] | 1 | hSpCas9 | negative selection | 11874810 | 25225670 | 25225693 | 12 | - | 28162770 | MV411 | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | 0.4028920694167544 | [166] | [185] | 3 | hSpCas9 | negative selection | 11874811 | 25227305 | 25227328 | 12 | - | 28162770 | MV411 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -0.681479351155742 | [98] | [51] | -5 | hSpCas9 | negative selection | 11874812 | 25227345 | 25227368 | 12 | - | 28162770 | MV411 | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | 0.399068767684746 | [387] | [430] | 3 | hSpCas9 | negative selection | 11874813 | 25227295 | 25227318 | 12 | - | 28162770 | MONOMAC1 | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | -0.6564684656968511 | [87] | [63] | -5 | hSpCas9 | negative selection | 12044172 | 25245310 | 25245333 | 12 | + | 28162770 | MONOMAC1 | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | 1.718265988365165 | [56] | [214] | 9 | hSpCas9 | negative selection | 12044173 | 25245341 | 25245364 | 12 | - | 28162770 | MONOMAC1 | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | -1.5727943586765862 | [313] | [120] | -8 | hSpCas9 | negative selection | 12044174 | 25227320 | 25227343 | 12 | - | 28162770 | MONOMAC1 | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | 0.695249335640193 | [138] | [257] | 6 | hSpCas9 | negative selection | 12044175 | 25225730 | 25225753 | 12 | - | 28162770 | MONOMAC1 | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | -1.4064902126885035 | [258] | [111] | -8 | hSpCas9 | negative selection | 12044176 | 25225670 | 25225693 | 12 | - | 28162770 | MONOMAC1 | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | 0.4094267228725247 | [110] | [168] | 4 | hSpCas9 | negative selection | 12044177 | 25227305 | 25227328 | 12 | - | 28162770 | MONOMAC1 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -1.2779568424431211 | [54] | [25] | -7 | hSpCas9 | negative selection | 12044178 | 25227345 | 25227368 | 12 | - | 28162770 | MONOMAC1 | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | -0.031158678679943375 | [237] | [266] | 0 | hSpCas9 | negative selection | 12044179 | 25227295 | 25227318 | 12 | - | 28162770 | OCIAML2 | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | 0.34433828092531793 | [26] | [189] | 3 | hSpCas9 | negative selection | 12213538 | 25245310 | 25245333 | 12 | + | 28162770 | OCIAML2 | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | 0.6618204707814882 | [12] | [113] | 6 | hSpCas9 | negative selection | 12213539 | 25245341 | 25245364 | 12 | - | 28162770 | OCIAML2 | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | -0.062237639605329576 | [67] | [360] | 0 | hSpCas9 | negative selection | 12213540 | 25227320 | 25227343 | 12 | - | 28162770 | OCIAML2 | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | 0.9613210569730293 | [52] | [571] | 8 | hSpCas9 | negative selection | 12213541 | 25225730 | 25225753 | 12 | - | 28162770 | OCIAML2 | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | 0.3924883683374516 | [57] | [421] | 4 | hSpCas9 | negative selection | 12213542 | 25225670 | 25225693 | 12 | - | 28162770 | OCIAML2 | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | 0.8789546125480666 | [30] | [315] | 8 | hSpCas9 | negative selection | 12213543 | 25227305 | 25227328 | 12 | - | 28162770 | OCIAML2 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | 0.7728242116221165 | [16] | [160] | 7 | hSpCas9 | negative selection | 12213544 | 25227345 | 25227368 | 12 | - | 28162770 | OCIAML2 | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | 0.7503104620603744 | [70] | [661] | 7 | hSpCas9 | negative selection | 12213545 | 25227295 | 25227318 | 12 | - | 28162770 | OCIAML3 | viability | CCAGTACATGAGGACTGGGGAGG | KRAS | ENSG00000133703 | -1.4930787314733824 | [68] | [73] | -7 | hSpCas9 | negative selection | 12382904 | 25245310 | 25245333 | 12 | + | 28162770 | OCIAML3 | viability | CTGAATTAGCTGTATCGTCAAGG | KRAS | ENSG00000133703 | 0.6180428367908258 | [29] | [138] | 5 | hSpCas9 | negative selection | 12382905 | 25245341 | 25245364 | 12 | - | 28162770 | OCIAML3 | viability | GTAGTTGGAGCTGGTGGCGTAGG | KRAS | ENSG00000133703 | -0.6138161214043436 | [109] | [216] | -5 | hSpCas9 | negative selection | 12382906 | 25227320 | 25227343 | 12 | - | 28162770 | OCIAML3 | viability | AAGAGGAGTACAGTGCAATGAGG | KRAS | ENSG00000133703 | -1.043315041687753 | [70] | [103] | -6 | hSpCas9 | negative selection | 12382907 | 25225730 | 25225753 | 12 | - | 28162770 | OCIAML3 | viability | GGACTCTGAAGATGTACCTATGG | KRAS | ENSG00000133703 | -0.22722530965254029 | [75] | [195] | -2 | hSpCas9 | negative selection | 12382908 | 25225670 | 25225693 | 12 | - | 28162770 | OCIAML3 | viability | AGTAGACACAAAACAGGCTCAGG | KRAS | ENSG00000133703 | -0.5642602969301111 | [47] | [97] | -4 | hSpCas9 | negative selection | 12382909 | 25227305 | 25227328 | 12 | - | 28162770 | OCIAML3 | viability | CAATGAGGGACCAGTACATGAGG | KRAS | ENSG00000133703 | -1.1442047228846428 | [40] | [55] | -7 | hSpCas9 | negative selection | 12382910 | 25227345 | 25227368 | 12 | - | 28162770 | OCIAML3 | viability | TTGGATATTCTCGACACAGCAGG | KRAS | ENSG00000133703 | 0.6784870947586968 | [94] | [458] | 6 | hSpCas9 | negative selection | 12382911 |