| 36940026 | 36940049 | CHR_HSCHR17_7_CTG4 | - | 26472758 | Jiyoye | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000274577 | 0.24081699508375332 | [302] | [269] | 1 | hSpCas9 | negative selection | 90369 | 36938196 | 36938219 | 17 | - | 26472758 | Jiyoye | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | 0.24081699508375332 | [302] | [269] | 1 | hSpCas9 | negative selection | 90370 | 36940026 | 36940049 | CHR_HSCHR17_7_CTG4 | - | 26472758 | KBM7 | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000274577 | 0.8218288701837797 | [1429,886] | [1218,698] | 8 | hSpCas9 | negative selection | 281487 | 36938196 | 36938219 | 17 | - | 26472758 | KBM7 | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | 0.8218288701837797 | [1429,886] | [1218,698] | 8 | hSpCas9 | negative selection | 281488 | 36940026 | 36940049 | CHR_HSCHR17_7_CTG4 | - | 26472758 | Raji | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000274577 | 0.6608045188083653 | [446] | [163] | 6 | hSpCas9 | negative selection | 472605 | 36938196 | 36938219 | 17 | - | 26472758 | Raji | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | 0.6608045188083653 | [446] | [163] | 6 | hSpCas9 | negative selection | 472606 | 36940026 | 36940049 | CHR_HSCHR17_7_CTG4 | - | 26472758 | K562 | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000274577 | 0.39737065050504583 | [911] | [1013] | 3 | hSpCas9 | negative selection | 663723 | 36938196 | 36938219 | 17 | - | 26472758 | K562 | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | 0.39737065050504583 | [911] | [1013] | 3 | hSpCas9 | negative selection | 663724 | 36938241 | 36938264 | 17 | + | 26627737 | DLD1 | viability | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.0626887276778269 | [356] | [38,137,165] | 0 | hSpCas9 | negative selection | 797192 | 36938241 | 36938264 | 17 | + | 26627737 | GBM cells | viability after 5 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | -0.4847332052456116 | [196] | [73,76] | -6 | hSpCas9 | negative selection | 879507 | 36938241 | 36938264 | 17 | + | 26627737 | GBM cells | viability after 13 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | -0.3000567156998223 | [196] | [61,106] | -4 | hSpCas9 | negative selection | 961822 | 36938241 | 36938264 | 17 | + | 26627737 | GBM cells | viability after 21 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.4108606784550515 | [196] | [158,126] | 4 | hSpCas9 | negative selection | 1044137 | 36938241 | 36938264 | 17 | + | 26627737 | RPE1 | viability after 9 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.7817462947790972 | [400] | [193,243] | 5 | hSpCas9 | negative selection | 1126452 | 36938241 | 36938264 | 17 | + | 26627737 | RPE1 | viability after 12 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 1.2986570729192546 | [400] | [197,335] | 7 | hSpCas9 | negative selection | 1208767 | 36938241 | 36938264 | 17 | + | 26627737 | RPE1 | viability after 15 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 1.489368271275861 | [400] | [234,398] | 7 | hSpCas9 | negative selection | 1291082 | 36938241 | 36938264 | 17 | + | 26627737 | RPE1 | viability after 18 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 1.4030132443497445 | [400] | [276,295] | 7 | hSpCas9 | negative selection | 1373397 | 36938241 | 36938264 | 17 | + | 26627737 | HeLa | viability after 8 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.8318920711102247 | [184] | [109,175,136] | 6 | hSpCas9 | negative selection | 1455712 | 36938241 | 36938264 | 17 | + | 26627737 | HeLa | viability after 12 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.8902220343576723 | [184] | [167,149,106] | 7 | hSpCas9 | negative selection | 1538027 | 36938241 | 36938264 | 17 | + | 26627737 | HeLa | viability after 15 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 1.2825031666577107 | [184] | [206,162,178] | 8 | hSpCas9 | negative selection | 1620342 | 36938241 | 36938264 | 17 | + | 26627737 | HeLa | viability after 18 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 1.3095146319892177 | [184] | [143,136,178] | 8 | hSpCas9 | negative selection | 1702657 | 36938241 | 36938264 | 17 | + | 26627737 | HCT116 | viability after 6 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | -0.4420164416708352 | [349] | [93,10] | -3 | hSpCas9 | negative selection | 1784972 | 36938241 | 36938264 | 17 | + | 26627737 | HCT116 | viability after 8 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.6730961991531379 | [103] | [102,134,36] | 6 | hSpCas9 | negative selection | 1867287 | 36938241 | 36938264 | 17 | + | 26627737 | HCT116 | viability after 9 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | -0.0151911598330019 | [349] | [168,31] | 0 | hSpCas9 | negative selection | 1949602 | 36938241 | 36938264 | 17 | + | 26627737 | HCT116 | viability after 12 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 1.291187824902034 | [103] | [165,156,75] | 8 | hSpCas9 | negative selection | 2031917 | 36938241 | 36938264 | 17 | + | 26627737 | HCT116 | viability after 15 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 1.0004009974341082 | [103] | [180,69,114] | 8 | hSpCas9 | negative selection | 2114232 | 36938241 | 36938264 | 17 | + | 26627737 | HCT116 | viability after 18 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.7614980187845533 | [103] | [72,121,56] | 6 | hSpCas9 | negative selection | 2196547 | 36938192 | 36938215 | 17 | + | 24336569 | HL60 | viability | AAGACCATGGTTCACTGTGCCGG | LHX1 | ENSG00000273706 | -0.08534753511612453 | [371] | [741] | 0 | hSpCas9 | negative selection | 2274631 | 36938225 | 36938248 | 17 | - | 24336569 | HL60 | viability | AAGAGAAAGCGGTCCAGGATGGG | LHX1 | ENSG00000273706 | -0.26357851107912267 | [935] | [1649] | -2 | hSpCas9 | negative selection | 2274632 | 36938230 | 36938253 | 17 | - | 24336569 | HL60 | viability | CGTTCAAGAGAAAGCGGTCCAGG | LHX1 | ENSG00000273706 | -0.019454438353471826 | [295] | [617] | 0 | hSpCas9 | negative selection | 2274633 | 36938236 | 36938259 | 17 | + | 24336569 | HL60 | viability | CCGCTTTCTCTTGAACGTGCTGG | LHX1 | ENSG00000273706 | 0.4540686908365081 | [286] | [831] | 4 | hSpCas9 | negative selection | 2274634 | 36938241 | 36938264 | 17 | + | 24336569 | HL60 | viability | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | -0.05738996565003873 | [831] | [1691] | 0 | hSpCas9 | negative selection | 2274635 | 36938247 | 36938270 | 17 | + | 24336569 | HL60 | viability | TGAACGTGCTGGACAGGGCCTGG | LHX1 | ENSG00000273706 | -0.279021118972574 | [1386] | [2418] | -2 | hSpCas9 | negative selection | 2274636 | 36938265 | 36938288 | 17 | - | 24336569 | HL60 | viability | CTGGACGCACTTGACGTGCCAGG | LHX1 | ENSG00000273706 | 0.4315051864982721 | [314] | [898] | 4 | hSpCas9 | negative selection | 2274637 | 36938284 | 36938307 | 17 | - | 24336569 | HL60 | viability | TGCATTTACATTCACAGCACTGG | LHX1 | ENSG00000273706 | -0.8162748100914285 | [445] | [535] | -6 | hSpCas9 | negative selection | 2274638 | 36938308 | 36938331 | 17 | - | 24336569 | HL60 | viability | TGGAGAAGCACTTCTCGGTCAGG | LHX1 | ENSG00000273706 | 0.7151288524455646 | [345] | [1201] | 6 | hSpCas9 | negative selection | 2274639 | 36938313 | 36938336 | 17 | - | 24336569 | HL60 | viability | TTCCCTGGAGAAGCACTTCTCGG | LHX1 | ENSG00000273706 | 0.25008556038947616 | [268] | [676] | 2 | hSpCas9 | negative selection | 2274640 | 36938192 | 36938215 | 17 | + | 24336569 | KBM7 | viability | AAGACCATGGTTCACTGTGCCGG | LHX1 | ENSG00000273706 | 0.4431286581671814 | [513] | [1905] | 4 | hSpCas9 | negative selection | 2341808 | 36938225 | 36938248 | 17 | - | 24336569 | KBM7 | viability | AAGAGAAAGCGGTCCAGGATGGG | LHX1 | ENSG00000273706 | -0.37835116142442754 | [650] | [1365] | -3 | hSpCas9 | negative selection | 2341809 | 36938230 | 36938253 | 17 | - | 24336569 | KBM7 | viability | CGTTCAAGAGAAAGCGGTCCAGG | LHX1 | ENSG00000273706 | 0.937251468167855 | [183] | [960] | 7 | hSpCas9 | negative selection | 2341810 | 36938236 | 36938259 | 17 | + | 24336569 | KBM7 | viability | CCGCTTTCTCTTGAACGTGCTGG | LHX1 | ENSG00000273706 | -0.2047949863812567 | [280] | [664] | -2 | hSpCas9 | negative selection | 2341811 | 36938241 | 36938264 | 17 | + | 24336569 | KBM7 | viability | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.5867855063796846 | [642] | [2633] | 5 | hSpCas9 | negative selection | 2341812 | 36938247 | 36938270 | 17 | + | 24336569 | KBM7 | viability | TGAACGTGCTGGACAGGGCCTGG | LHX1 | ENSG00000273706 | 0.6090666301776272 | [667] | [2778] | 5 | hSpCas9 | negative selection | 2341813 | 36938265 | 36938288 | 17 | - | 24336569 | KBM7 | viability | CTGGACGCACTTGACGTGCCAGG | LHX1 | ENSG00000273706 | 0.6792355648053343 | [350] | [1532] | 6 | hSpCas9 | negative selection | 2341814 | 36938284 | 36938307 | 17 | - | 24336569 | KBM7 | viability | TGCATTTACATTCACAGCACTGG | LHX1 | ENSG00000273706 | -0.379099458666116 | [287] | [603] | -3 | hSpCas9 | negative selection | 2341815 | 36938308 | 36938331 | 17 | - | 24336569 | KBM7 | viability | TGGAGAAGCACTTCTCGGTCAGG | LHX1 | ENSG00000273706 | 0.3997694534052305 | [370] | [1334] | 3 | hSpCas9 | negative selection | 2341816 | 36938313 | 36938336 | 17 | - | 24336569 | KBM7 | viability | TTCCCTGGAGAAGCACTTCTCGG | LHX1 | ENSG00000273706 | -0.801783694460001 | [564] | [883] | -6 | hSpCas9 | negative selection | 2341817 | 36939190 | 36939213 | CHR_HSCHR17_7_CTG4 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | AGGGAAGGAGCGAGTGCGCCTGG | LHX1 | ENSG00000274577 | 4.058911249664017 | [70,6] | [29,260] | 9 | dCas9-VP64 | positive selection | 2438291 | 36937360 | 36937383 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | AGGGAAGGAGCGAGTGCGCCTGG | LHX1 | ENSG00000273706 | 4.058911249664017 | [70,6] | [29,260] | 9 | dCas9-VP64 | positive selection | 2438292 | 36937313 | 36937336 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GAGGCCGCCAGGCAGGCCAAGGG | LHX1 | ENSG00000273706 | -1.1332284259631777 | [194,6] | [14,2] | -6 | dCas9-VP64 | positive selection | 2438293 | 36939143 | 36939166 | CHR_HSCHR17_7_CTG4 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GAGGCCGCCAGGCAGGCCAAGGG | LHX1 | ENSG00000274577 | -1.1332284259631777 | [194,6] | [14,2] | -6 | dCas9-VP64 | positive selection | 2438294 | 36939121 | 36939144 | CHR_HSCHR17_7_CTG4 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GGAGGGTCGCCCTGAGGACACGG | LHX1 | ENSG00000274577 | 1.2590257488124865 | [35,30] | [26,7] | 5 | dCas9-VP64 | positive selection | 2438295 | 36937291 | 36937314 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (puromycin) | GGAGGGTCGCCCTGAGGACACGG | LHX1 | ENSG00000273706 | 1.2590257488124865 | [35,30] | [26,7] | 5 | dCas9-VP64 | positive selection | 2438296 | 36939190 | 36939213 | CHR_HSCHR17_7_CTG4 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | AGGGAAGGAGCGAGTGCGCCTGG | LHX1 | ENSG00000274577 | -0.12291918432891902 | [94,67] | [37,10] | -1 | dCas9-VP64 | positive selection | 2533546 | 36937360 | 36937383 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | AGGGAAGGAGCGAGTGCGCCTGG | LHX1 | ENSG00000273706 | -0.12291918432891902 | [94,67] | [37,10] | -1 | dCas9-VP64 | positive selection | 2533547 | 36937313 | 36937336 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GAGGCCGCCAGGCAGGCCAAGGG | LHX1 | ENSG00000273706 | 0.51162211890238 | [66,21] | [30,10] | 4 | dCas9-VP64 | positive selection | 2533548 | 36939143 | 36939166 | CHR_HSCHR17_7_CTG4 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GAGGCCGCCAGGCAGGCCAAGGG | LHX1 | ENSG00000274577 | 0.51162211890238 | [66,21] | [30,10] | 4 | dCas9-VP64 | positive selection | 2533549 | 36939121 | 36939144 | CHR_HSCHR17_7_CTG4 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GGAGGGTCGCCCTGAGGACACGG | LHX1 | ENSG00000274577 | -0.26368943391005684 | [173,117] | [46,32] | -2 | dCas9-VP64 | positive selection | 2533550 | 36937291 | 36937314 | 17 | + | 25494202 | A375 | resistance to PLX-4720 (zeocin) | GGAGGGTCGCCCTGAGGACACGG | LHX1 | ENSG00000273706 | -0.26368943391005684 | [173,117] | [46,32] | -2 | dCas9-VP64 | positive selection | 2533551 | 36938265 | 36938288 | 17 | - | 27260157 | DLD1 | viability | CTGGACGCACTTGACGTGCCAGG | LHX1 | ENSG00000273706 | 1.02891436648963 | [] | [] | 9 | hSpCas9 | negative selection | 2579072 | 36938313 | 36938336 | 17 | - | 27260157 | DLD1 | viability | TTCCCTGGAGAAGCACTTCTCGG | LHX1 | ENSG00000273706 | 0.887534001966447 | [] | [] | 9 | hSpCas9 | negative selection | 2581577 | 36938225 | 36938248 | 17 | - | 27260157 | DLD1 | viability | AAGAGAAAGCGGTCCAGGATGGG | LHX1 | ENSG00000273706 | 0.104167082321704 | [] | [] | 3 | hSpCas9 | negative selection | 2581594 | 36938230 | 36938253 | 17 | - | 27260157 | DLD1 | viability | CGTTCAAGAGAAAGCGGTCCAGG | LHX1 | ENSG00000273706 | -0.243224413646402 | [] | [] | -2 | hSpCas9 | negative selection | 2586391 | 36938284 | 36938307 | 17 | - | 27260157 | DLD1 | viability | TGCATTTACATTCACAGCACTGG | LHX1 | ENSG00000273706 | 0.870756093781253 | [] | [] | 9 | hSpCas9 | negative selection | 2605508 | 36938241 | 36938264 | 17 | + | 27260157 | DLD1 | viability | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.337051640926424 | [] | [] | 4 | hSpCas9 | negative selection | 2607523 | 36938247 | 36938270 | 17 | + | 27260157 | DLD1 | viability | TGAACGTGCTGGACAGGGCCTGG | LHX1 | ENSG00000273706 | 0.800201010418416 | [] | [] | 9 | hSpCas9 | negative selection | 2612562 | 36938192 | 36938215 | 17 | + | 27260157 | DLD1 | viability | AAGACCATGGTTCACTGTGCCGG | LHX1 | ENSG00000273706 | -0.0620699071596508 | [] | [] | 0 | hSpCas9 | negative selection | 2614800 | 36938236 | 36938259 | 17 | + | 27260157 | DLD1 | viability | CCGCTTTCTCTTGAACGTGCTGG | LHX1 | ENSG00000273706 | -1.26499691751675 | [] | [] | -7 | hSpCas9 | negative selection | 2623569 | 36938308 | 36938331 | 17 | - | 27260157 | DLD1 | viability | TGGAGAAGCACTTCTCGGTCAGG | LHX1 | ENSG00000273706 | -0.0769646394496257 | [] | [] | 0 | hSpCas9 | negative selection | 2648705 | 36938265 | 36938288 | 17 | - | 27260157 | HT1080 | viability | CTGGACGCACTTGACGTGCCAGG | LHX1 | ENSG00000273706 | 1.19107194027728 | [] | [] | 8 | hSpCas9 | negative selection | 2655202 | 36938313 | 36938336 | 17 | - | 27260157 | HT1080 | viability | TTCCCTGGAGAAGCACTTCTCGG | LHX1 | ENSG00000273706 | 0.801155366227057 | [] | [] | 7 | hSpCas9 | negative selection | 2657707 | 36938225 | 36938248 | 17 | - | 27260157 | HT1080 | viability | AAGAGAAAGCGGTCCAGGATGGG | LHX1 | ENSG00000273706 | 0.394955733337796 | [] | [] | 3 | hSpCas9 | negative selection | 2657724 | 36938230 | 36938253 | 17 | - | 27260157 | HT1080 | viability | CGTTCAAGAGAAAGCGGTCCAGG | LHX1 | ENSG00000273706 | -1.48749866594047 | [] | [] | -9 | hSpCas9 | negative selection | 2662521 | 36938284 | 36938307 | 17 | - | 27260157 | HT1080 | viability | TGCATTTACATTCACAGCACTGG | LHX1 | ENSG00000273706 | 0.841583330369886 | [] | [] | 7 | hSpCas9 | negative selection | 2681638 | 36938241 | 36938264 | 17 | + | 27260157 | HT1080 | viability | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.885645627337968 | [] | [] | 7 | hSpCas9 | negative selection | 2683653 | 36938247 | 36938270 | 17 | + | 27260157 | HT1080 | viability | TGAACGTGCTGGACAGGGCCTGG | LHX1 | ENSG00000273706 | 0.669360438055816 | [] | [] | 6 | hSpCas9 | negative selection | 2688692 | 36938192 | 36938215 | 17 | + | 27260157 | HT1080 | viability | AAGACCATGGTTCACTGTGCCGG | LHX1 | ENSG00000273706 | 1.04777695062261 | [] | [] | 8 | hSpCas9 | negative selection | 2690930 | 36938236 | 36938259 | 17 | + | 27260157 | HT1080 | viability | CCGCTTTCTCTTGAACGTGCTGG | LHX1 | ENSG00000273706 | -1.16684457447917 | [] | [] | -8 | hSpCas9 | negative selection | 2699699 | 36938308 | 36938331 | 17 | - | 27260157 | HT1080 | viability | TGGAGAAGCACTTCTCGGTCAGG | LHX1 | ENSG00000273706 | -0.0233133177363879 | [] | [] | 0 | hSpCas9 | negative selection | 2724835 | 36938265 | 36938288 | 17 | - | 27260157 | MKN45 | viability | CTGGACGCACTTGACGTGCCAGG | LHX1 | ENSG00000273706 | 1.12039694474729 | [] | [] | 8 | hSpCas9 | negative selection | 2731332 | 36938313 | 36938336 | 17 | - | 27260157 | MKN45 | viability | TTCCCTGGAGAAGCACTTCTCGG | LHX1 | ENSG00000273706 | 0.171280995060055 | [] | [] | 5 | hSpCas9 | negative selection | 2733837 | 36938225 | 36938248 | 17 | - | 27260157 | MKN45 | viability | AAGAGAAAGCGGTCCAGGATGGG | LHX1 | ENSG00000273706 | 0.919628498022357 | [] | [] | 8 | hSpCas9 | negative selection | 2733854 | 36938230 | 36938253 | 17 | - | 27260157 | MKN45 | viability | CGTTCAAGAGAAAGCGGTCCAGG | LHX1 | ENSG00000273706 | -0.992126675185821 | [] | [] | -7 | hSpCas9 | negative selection | 2738651 | 36938284 | 36938307 | 17 | - | 27260157 | MKN45 | viability | TGCATTTACATTCACAGCACTGG | LHX1 | ENSG00000273706 | 0.00611433799015201 | [] | [] | 0 | hSpCas9 | negative selection | 2757768 | 36938241 | 36938264 | 17 | + | 27260157 | MKN45 | viability | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.302029639959777 | [] | [] | 5 | hSpCas9 | negative selection | 2759783 | 36938247 | 36938270 | 17 | + | 27260157 | MKN45 | viability | TGAACGTGCTGGACAGGGCCTGG | LHX1 | ENSG00000273706 | 0.310495123770094 | [] | [] | 5 | hSpCas9 | negative selection | 2764822 | 36938192 | 36938215 | 17 | + | 27260157 | MKN45 | viability | AAGACCATGGTTCACTGTGCCGG | LHX1 | ENSG00000273706 | 0.0736443158053714 | [] | [] | 0 | hSpCas9 | negative selection | 2767060 | 36938236 | 36938259 | 17 | + | 27260157 | MKN45 | viability | CCGCTTTCTCTTGAACGTGCTGG | LHX1 | ENSG00000273706 | -2.14479636408316 | [] | [] | -9 | hSpCas9 | negative selection | 2775829 | 36938308 | 36938331 | 17 | - | 27260157 | MKN45 | viability | TGGAGAAGCACTTCTCGGTCAGG | LHX1 | ENSG00000273706 | -1.33402070149543 | [] | [] | -8 | hSpCas9 | negative selection | 2800965 | 36938265 | 36938288 | 17 | - | 27260157 | RKO | viability | CTGGACGCACTTGACGTGCCAGG | LHX1 | ENSG00000273706 | 1.1883649641899 | [] | [] | 9 | hSpCas9 | negative selection | 2807462 | 36938313 | 36938336 | 17 | - | 27260157 | RKO | viability | TTCCCTGGAGAAGCACTTCTCGG | LHX1 | ENSG00000273706 | 0.224370080838561 | [] | [] | 1 | hSpCas9 | negative selection | 2809967 | 36938225 | 36938248 | 17 | - | 27260157 | RKO | viability | AAGAGAAAGCGGTCCAGGATGGG | LHX1 | ENSG00000273706 | 0.768790171907436 | [] | [] | 8 | hSpCas9 | negative selection | 2809984 | 36938230 | 36938253 | 17 | - | 27260157 | RKO | viability | CGTTCAAGAGAAAGCGGTCCAGG | LHX1 | ENSG00000273706 | -0.678324954948196 | [] | [] | -7 | hSpCas9 | negative selection | 2814781 | 36938284 | 36938307 | 17 | - | 27260157 | RKO | viability | TGCATTTACATTCACAGCACTGG | LHX1 | ENSG00000273706 | 0.217738477445822 | [] | [] | 1 | hSpCas9 | negative selection | 2833898 | 36938241 | 36938264 | 17 | + | 27260157 | RKO | viability | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.532134273614232 | [] | [] | 3 | hSpCas9 | negative selection | 2835913 | 36938247 | 36938270 | 17 | + | 27260157 | RKO | viability | TGAACGTGCTGGACAGGGCCTGG | LHX1 | ENSG00000273706 | 0.998521765391558 | [] | [] | 9 | hSpCas9 | negative selection | 2840952 | 36938192 | 36938215 | 17 | + | 27260157 | RKO | viability | AAGACCATGGTTCACTGTGCCGG | LHX1 | ENSG00000273706 | 1.43008952370543 | [] | [] | 9 | hSpCas9 | negative selection | 2843190 | 36938236 | 36938259 | 17 | + | 27260157 | RKO | viability | CCGCTTTCTCTTGAACGTGCTGG | LHX1 | ENSG00000273706 | -1.77418191040107 | [] | [] | -9 | hSpCas9 | negative selection | 2851959 | 36938308 | 36938331 | 17 | - | 27260157 | RKO | viability | TGGAGAAGCACTTCTCGGTCAGG | LHX1 | ENSG00000273706 | 0.322596790393728 | [] | [] | 1 | hSpCas9 | negative selection | 2877095 | 36938265 | 36938288 | 17 | - | 27260157 | SF268 | viability | CTGGACGCACTTGACGTGCCAGG | LHX1 | ENSG00000273706 | 1.10086830949175 | [] | [] | 9 | hSpCas9 | negative selection | 2883592 | 36938313 | 36938336 | 17 | - | 27260157 | SF268 | viability | TTCCCTGGAGAAGCACTTCTCGG | LHX1 | ENSG00000273706 | 1.00923471470122 | [] | [] | 9 | hSpCas9 | negative selection | 2886097 | 36938225 | 36938248 | 17 | - | 27260157 | SF268 | viability | AAGAGAAAGCGGTCCAGGATGGG | LHX1 | ENSG00000273706 | -0.276983678778751 | [] | [] | -2 | hSpCas9 | negative selection | 2886114 | 36938230 | 36938253 | 17 | - | 27260157 | SF268 | viability | CGTTCAAGAGAAAGCGGTCCAGG | LHX1 | ENSG00000273706 | -0.324833954501529 | [] | [] | -3 | hSpCas9 | negative selection | 2890911 | 36938284 | 36938307 | 17 | - | 27260157 | SF268 | viability | TGCATTTACATTCACAGCACTGG | LHX1 | ENSG00000273706 | -0.397992020514827 | [] | [] | -3 | hSpCas9 | negative selection | 2910028 | 36938241 | 36938264 | 17 | + | 27260157 | SF268 | viability | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.941494248082951 | [] | [] | 9 | hSpCas9 | negative selection | 2912043 | 36938247 | 36938270 | 17 | + | 27260157 | SF268 | viability | TGAACGTGCTGGACAGGGCCTGG | LHX1 | ENSG00000273706 | 0.0963291334296027 | [] | [] | 0 | hSpCas9 | negative selection | 2917082 | 36938192 | 36938215 | 17 | + | 27260157 | SF268 | viability | AAGACCATGGTTCACTGTGCCGG | LHX1 | ENSG00000273706 | 0.222326561181695 | [] | [] | 3 | hSpCas9 | negative selection | 2919320 | 36938236 | 36938259 | 17 | + | 27260157 | SF268 | viability | CCGCTTTCTCTTGAACGTGCTGG | LHX1 | ENSG00000273706 | -2.04789642172318 | [] | [] | -8 | hSpCas9 | negative selection | 2928089 | 36938308 | 36938331 | 17 | - | 27260157 | SF268 | viability | TGGAGAAGCACTTCTCGGTCAGG | LHX1 | ENSG00000273706 | -0.416114369154696 | [] | [] | -3 | hSpCas9 | negative selection | 2953225 | 36938236 | 36938259 | 17 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | CCAGCACGTTCAAGAGAAAGCGG | LHX1 | ENSG00000273706 | 0.6133588579596867 | [3,2] | [3,4] | 9 | hSpCas9 | positive selection | 2999386 | 36938312 | 36938335 | 17 | + | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GACCGAGAAGTGCTTCTCCAGGG | LHX1 | ENSG00000273706 | -0.22440012628048908 | [2,3] | [2,1] | -3 | hSpCas9 | positive selection | 2999387 | 36938196 | 36938219 | 17 | - | 27453484 | HT29 | resistance to T3SS1-dependent cytotoxicity | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | -1.0512632036045664 | [2,2] | [1,0] | -9 | hSpCas9 | positive selection | 2999388 | 36938236 | 36938259 | 17 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | CCAGCACGTTCAAGAGAAAGCGG | LHX1 | ENSG00000273706 | 0.1746282859461628 | [3,3] | [2,2] | 3 | hSpCas9 | positive selection | 3067244 | 36938312 | 36938335 | 17 | + | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GACCGAGAAGTGCTTCTCCAGGG | LHX1 | ENSG00000273706 | -0.03098291529613717 | [2,2] | [3,0] | 0 | hSpCas9 | positive selection | 3067245 | 36938196 | 36938219 | 17 | - | 27453484 | HT29 | resistance to T3SS2-dependent cytotoxicity | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | -0.44297623088624943 | [2,2] | [1,0] | -6 | hSpCas9 | positive selection | 3067246 | 36938236 | 36938259 | 17 | - | 26780180 | HT29 | viability (Avana library 4 designs) | CCAGCACGTTCAAGAGAAAGCGG | LHX1 | ENSG00000273706 | 0.531027920110939 | [] | [] | 2 | hSpCas9 | negative selection | 3436933 | 36938311 | 36938334 | 17 | + | 26780180 | HT29 | viability (Avana library 4 designs) | GACCGAGAAGTGCTTCTCCAGGG | LHX1 | ENSG00000273706 | 0.41521903601743 | [] | [] | 1 | hSpCas9 | negative selection | 3436934 | 36938196 | 36938219 | 17 | - | 26780180 | HT29 | viability (Avana library 4 designs) | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | 2.73513426041117 | [] | [] | 8 | hSpCas9 | negative selection | 3436935 | 36938196 | 36938219 | 17 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | 5.4831137935089 | [] | [] | 8 | hSpCas9 | negative selection | 3525400 | 36938236 | 36938259 | 17 | - | 26780180 | A375 | viability (Avana lentiCRISPRv2) | CCAGCACGTTCAAGAGAAAGCGG | LHX1 | ENSG00000273706 | 4.07982100119233 | [] | [] | 6 | hSpCas9 | negative selection | 3525401 | 36938311 | 36938334 | 17 | + | 26780180 | A375 | viability (Avana lentiCRISPRv2) | GACCGAGAAGTGCTTCTCCAGGG | LHX1 | ENSG00000273706 | -2.32135975329293 | [] | [] | -3 | hSpCas9 | negative selection | 3525402 | 36938196 | 36938219 | 17 | - | 26780180 | A375 | viability (Avana lentiGuide) | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | 8.37301430043494 | [] | [] | 6 | hSpCas9 | negative selection | 3634059 | 36938236 | 36938259 | 17 | - | 26780180 | A375 | viability (Avana lentiGuide) | CCAGCACGTTCAAGAGAAAGCGG | LHX1 | ENSG00000273706 | -4.66281264257853 | [] | [] | -7 | hSpCas9 | negative selection | 3634060 | 36938311 | 36938334 | 17 | + | 26780180 | A375 | viability (Avana lentiGuide) | GACCGAGAAGTGCTTCTCCAGGG | LHX1 | ENSG00000273706 | 3.80154187609528 | [] | [] | 4 | hSpCas9 | negative selection | 3634061 | 36938196 | 36938219 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | -0.03192307238463493 | [4] | [4,3] | 0 | hSpCas9 | positive selection | 3742718 | 36938236 | 36938259 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | CCAGCACGTTCAAGAGAAAGCGG | LHX1 | ENSG00000273706 | 0.15237054138896947 | [4] | [5,4] | 4 | hSpCas9 | positive selection | 3742719 | 36938311 | 36938334 | 17 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiCRISPRv2) | GACCGAGAAGTGCTTCTCCAGGG | LHX1 | ENSG00000273706 | -0.12907156292663102 | [5] | [4,4] | -2 | hSpCas9 | positive selection | 3742720 | 36938196 | 36938219 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | -0.1635465512974077 | [5] | [3,4] | -2 | hSpCas9 | positive selection | 3851325 | 36938236 | 36938259 | 17 | - | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | CCAGCACGTTCAAGAGAAAGCGG | LHX1 | ENSG00000273706 | -0.15304294125073703 | [4] | [3,2] | -2 | hSpCas9 | positive selection | 3851326 | 36938311 | 36938334 | 17 | + | 26780180 | A375 | resistance to vemurafenib (Avana lentiGuide) | GACCGAGAAGTGCTTCTCCAGGG | LHX1 | ENSG00000273706 | 0.11545479481165231 | [5] | [4,4] | 2 | hSpCas9 | positive selection | 3851327 | 36937136 | 36937159 | 17 | + | 27661255 | K562 | viability | GCGACTGTGGGGTTAGACGGAGG | LHX1 | ENSG00000273706 | 0.08584224003943408 | [556,542] | [486,448] | 3 | dCas9-KRAB | negative selection | 5490232 | 36937291 | 36937314 | 17 | + | 27661255 | K562 | viability | GGAGGGTCGCCCTGAGGACACGG | LHX1 | ENSG00000273706 | 0.17060290873775397 | [1160,1214] | [1185,965] | 6 | dCas9-KRAB | negative selection | 5490233 | 36937341 | 36937364 | 17 | + | 27661255 | K562 | viability | GTGACTGGGCTGGGGCGGTAGGG | LHX1 | ENSG00000273706 | 0.08840536337403782 | [1049,1121] | [958,888] | 3 | dCas9-KRAB | negative selection | 5490234 | 36937909 | 36937932 | 17 | - | 27661255 | K562 | viability | GGGCGAGGAAAAGAAGTCTCAGG | LHX1 | ENSG00000273706 | 0.0312106789336285 | [1295,1205] | [1022,1021] | 1 | dCas9-KRAB | negative selection | 5490235 | 36938241 | 36938264 | 17 | + | 27869803 | HPAFII | viability after 27 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.26679968891515005 | [189] | [159,86,NaN] | 2 | hSpCas9 | negative selection | 9560210 | 36938241 | 36938264 | 17 | + | 27869803 | HPAFII | viability after 15 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | -0.14476499551032807 | [189] | [217,163,NaN] | -2 | hSpCas9 | negative selection | 9642659 | 36938241 | 36938264 | 17 | + | 27869803 | ASPC1 | viability after 36 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 1.8465208494863836 | [286] | [451,163,447] | 9 | hSpCas9 | negative selection | 9725108 | 36938241 | 36938264 | 17 | + | 27869803 | PATU8988S | viability after 35 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.15611812674534042 | [290] | [171,88,NaN] | 1 | hSpCas9 | negative selection | 9807557 | 36938241 | 36938264 | 17 | + | 27869803 | PATU8988S | viability after 31 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.28690884832805297 | [290] | [163,112,NaN] | 3 | hSpCas9 | negative selection | 9890006 | 36938241 | 36938264 | 17 | + | 27869803 | HPAFII | viability after 35 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.7887144188209578 | [189] | [144,189,NaN] | 5 | hSpCas9 | negative selection | 9972455 | 36938241 | 36938264 | 17 | + | 27869803 | HPAFII | viability after 31 days | TTCTCTTGAACGTGCTGGACAGG | LHX1 | ENSG00000273706 | 0.8123925319421033 | [189] | [192,180,NaN] | 6 | hSpCas9 | negative selection | 10054904 | 36938196 | 36938219 | 17 | - | 28162770 | P31FUJ | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | -0.4049416269221331 | [488] | [433] | -4 | hSpCas9 | negative selection | 10184306 | 36938196 | 36938219 | 17 | - | 28162770 | TF1 | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | NaN | [NaN] | [446] | 1 | hSpCas9 | negative selection | 10353672 | 36938196 | 36938219 | 17 | - | 28162770 | SKM1 | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | 0.08918903502013853 | [133] | [251] | 0 | hSpCas9 | negative selection | 10523038 | 36938196 | 36938219 | 17 | - | 28162770 | SKM1 | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | 0.08918903502013853 | [133] | [251] | 0 | hSpCas9 | negative selection | 10692404 | 36938196 | 36938219 | 17 | - | 28162770 | PL21 | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | -0.4276178259726223 | [478] | [154] | -3 | hSpCas9 | negative selection | 10861770 | 36938196 | 36938219 | 17 | - | 28162770 | P31FUJ | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | -0.4049416269221331 | [488] | [433] | -4 | hSpCas9 | negative selection | 11031136 | 36938196 | 36938219 | 17 | - | 28162770 | OCIAML5 | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | 0.2961166514242488 | [207] | [460] | 2 | hSpCas9 | negative selection | 11200502 | 36938196 | 36938219 | 17 | - | 28162770 | EOL1 | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | 0.2306508992962144 | [989] | [611] | 2 | hSpCas9 | negative selection | 11369868 | 36938196 | 36938219 | 17 | - | 28162770 | MOLM13 | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | -0.5232215266191518 | [808] | [406] | -3 | hSpCas9 | negative selection | 11539234 | 36938196 | 36938219 | 17 | - | 28162770 | HEL | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | 0.006932653864729188 | [591] | [380] | 0 | hSpCas9 | negative selection | 11708600 | 36938196 | 36938219 | 17 | - | 28162770 | MV411 | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | -0.41052678088128747 | [455] | [288] | -3 | hSpCas9 | negative selection | 11877966 | 36938196 | 36938219 | 17 | - | 28162770 | MONOMAC1 | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | -0.46833886887694787 | [349] | [289] | -4 | hSpCas9 | negative selection | 12047332 | 36938196 | 36938219 | 17 | - | 28162770 | OCIAML2 | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | 0.5913301668591906 | [93] | [784] | 6 | hSpCas9 | negative selection | 12216698 | 36938196 | 36938219 | 17 | - | 28162770 | OCIAML3 | viability | GCAGCCGGCACAGTGAACCATGG | LHX1 | ENSG00000273706 | 0.7826376242722677 | [118] | [617] | 7 | hSpCas9 | negative selection | 12386064 |