Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:4035
• Symbol:LRP1
• Description:LDL receptor related protein 1

DataSource: http://genomecrispr.dkfz.de/#!/results/LRP1

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
57129000	57129023	12	+	26472758	Jiyoye	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	0.5327062635897324	[54]	[59]	4	hSpCas9	negative selection	92315
57143777	57143800	12	+	26472758	Jiyoye	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	-0.7627496199364392	[35]	[15]	-5	hSpCas9	negative selection	92316
57176064	57176087	12	+	26472758	Jiyoye	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	0.9754591410803992	[144]	[214]	6	hSpCas9	negative selection	92317
57178518	57178541	12	+	26472758	Jiyoye	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	0.6348044512084685	[274]	[321]	4	hSpCas9	negative selection	92318
57184898	57184921	12	+	26472758	Jiyoye	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	0.3704168314957555	[158]	[154]	2	hSpCas9	negative selection	92319
57197114	57197137	12	+	26472758	Jiyoye	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	0.4375490305493922	[140]	[143]	3	hSpCas9	negative selection	92320
57211772	57211795	12	-	26472758	Jiyoye	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	0.5810048374041019	[163]	[184]	4	hSpCas9	negative selection	92321
57128972	57128995	12	-	26472758	Jiyoye	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	-1.1246757827557203	[239]	[82]	-6	hSpCas9	negative selection	92322
57141490	57141513	12	+	26472758	Jiyoye	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	-0.41998802163191096	[54]	[30]	-3	hSpCas9	negative selection	92323
57143742	57143765	12	-	26472758	Jiyoye	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	-0.9503766231122103	[204]	[79]	-6	hSpCas9	negative selection	92325
57129000	57129023	12	+	26472758	KBM7	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	0.15894252809197873	[312,140]	[74,150]	1	hSpCas9	negative selection	283433
57143777	57143800	12	+	26472758	KBM7	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	0.19747640194538674	[140,126]	[20,117]	2	hSpCas9	negative selection	283434
57176064	57176087	12	+	26472758	KBM7	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	0.6402342181089088	[797,615]	[592,442]	7	hSpCas9	negative selection	283435
57178518	57178541	12	+	26472758	KBM7	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	0.5772498552104923	[1170,720]	[655,645]	6	hSpCas9	negative selection	283436
57184898	57184921	12	+	26472758	KBM7	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	-0.3199406916612852	[625,379]	[163,204]	-3	hSpCas9	negative selection	283437
57197114	57197137	12	+	26472758	KBM7	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	-0.11667714557146502	[372,223]	[64,181]	-1	hSpCas9	negative selection	283438
57211772	57211795	12	-	26472758	KBM7	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	0.197991868206852	[915,1047]	[462,600]	2	hSpCas9	negative selection	283439
57128972	57128995	12	-	26472758	KBM7	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	-0.7860282780794671	[563,333]	[75,158]	-6	hSpCas9	negative selection	283440
57141490	57141513	12	+	26472758	KBM7	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	-0.14575928854159326	[191,65]	[73,32]	-1	hSpCas9	negative selection	283441
57143742	57143765	12	-	26472758	KBM7	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	0.061130376509770976	[458,449]	[217,228]	0	hSpCas9	negative selection	283443
57129000	57129023	12	+	26472758	Raji	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	0.317306604747831	[82]	[23]	3	hSpCas9	negative selection	474551
57143777	57143800	12	+	26472758	Raji	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	-0.9432425376963687	[115]	[13]	-6	hSpCas9	negative selection	474552
57176064	57176087	12	+	26472758	Raji	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	0.03481490942295462	[529]	[125]	0	hSpCas9	negative selection	474553
57178518	57178541	12	+	26472758	Raji	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	0.9945829328974729	[358]	[165]	8	hSpCas9	negative selection	474554
57184898	57184921	12	+	26472758	Raji	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	-0.9913504182117603	[256]	[29]	-6	hSpCas9	negative selection	474555
57197114	57197137	12	+	26472758	Raji	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	-0.5092878250748949	[183]	[29]	-4	hSpCas9	negative selection	474556
57211772	57211795	12	-	26472758	Raji	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	0.5000035685448461	[453]	[148]	5	hSpCas9	negative selection	474557
57128972	57128995	12	-	26472758	Raji	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	-0.3989691306511902	[249]	[43]	-3	hSpCas9	negative selection	474558
57141490	57141513	12	+	26472758	Raji	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	-0.2759451041779064	[119]	[22]	-2	hSpCas9	negative selection	474559
57143742	57143765	12	-	26472758	Raji	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	-0.2737066319819066	[223]	[42]	-2	hSpCas9	negative selection	474561
57129000	57129023	12	+	26472758	K562	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	-0.12964699055609064	[161]	[124]	-1	hSpCas9	negative selection	665669
57143777	57143800	12	+	26472758	K562	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	-1.1233130568340404	[159]	[61]	-6	hSpCas9	negative selection	665670
57176064	57176087	12	+	26472758	K562	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	-1.2245504779898895	[644]	[232]	-6	hSpCas9	negative selection	665671
57178518	57178541	12	+	26472758	K562	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	-0.36121310999003087	[702]	[461]	-2	hSpCas9	negative selection	665672
57184898	57184921	12	+	26472758	K562	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	-0.13568498150300978	[543]	[417]	-1	hSpCas9	negative selection	665673
57197114	57197137	12	+	26472758	K562	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	-0.4395537788858749	[195]	[121]	-3	hSpCas9	negative selection	665674
57211772	57211795	12	-	26472758	K562	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	-0.19239571400764854	[711]	[525]	-1	hSpCas9	negative selection	665675
57128972	57128995	12	-	26472758	K562	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	0.060845555220526946	[384]	[338]	0	hSpCas9	negative selection	665676
57141490	57141513	12	+	26472758	K562	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	-1.6486660684170413	[77]	[20]	-7	hSpCas9	negative selection	665677
57143742	57143765	12	-	26472758	K562	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	-0.30510410379941744	[381]	[260]	-2	hSpCas9	negative selection	665679
57128996	57129019	12	-	26627737	DLD1	viability	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.3452856312142363	[899]	[319,390,361]	3	hSpCas9	negative selection	784864
57138504	57138527	12	+	26627737	DLD1	viability	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	0.2585199271511158	[190]	[46,82,82]	2	hSpCas9	negative selection	784865
57141442	57141465	12	+	26627737	DLD1	viability	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	1.4561726558179429	[209]	[282,109,148]	9	hSpCas9	negative selection	784866
57143683	57143706	12	+	26627737	DLD1	viability	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	1.7203301597468406	[136]	[135,177,114]	9	hSpCas9	negative selection	784867
57149703	57149726	12	+	26627737	DLD1	viability	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-0.4699119797869615	[795]	[125,174,229]	-5	hSpCas9	negative selection	784868
57128996	57129019	12	-	26627737	GBM cells	viability after 5 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	-0.0517115141407396	[516]	[312,221]	-1	hSpCas9	negative selection	867179
57138504	57138527	12	+	26627737	GBM cells	viability after 5 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-0.8209782059215793	[195]	[48,69]	-8	hSpCas9	negative selection	867180
57141442	57141465	12	+	26627737	GBM cells	viability after 5 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	-0.19822728352484612	[214]	[106,93]	-3	hSpCas9	negative selection	867181
57143683	57143706	12	+	26627737	GBM cells	viability after 5 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	0.5439314990778042	[148]	[119,112]	7	hSpCas9	negative selection	867182
57149703	57149726	12	+	26627737	GBM cells	viability after 5 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-0.18480795101181735	[336]	[157,159]	-3	hSpCas9	negative selection	867183
57128996	57129019	12	-	26627737	GBM cells	viability after 13 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	-0.13631644327081804	[516]	[284,230]	-2	hSpCas9	negative selection	949494
57138504	57138527	12	+	26627737	GBM cells	viability after 13 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-0.603323703591794	[195]	[69,69]	-6	hSpCas9	negative selection	949495
57141442	57141465	12	+	26627737	GBM cells	viability after 13 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	0.25658603760089327	[214]	[97,172]	3	hSpCas9	negative selection	949496
57143683	57143706	12	+	26627737	GBM cells	viability after 13 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	0.006446934454015674	[148]	[78,82]	0	hSpCas9	negative selection	949497
57149703	57149726	12	+	26627737	GBM cells	viability after 13 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-0.25545076568811476	[336]	[161,145]	-3	hSpCas9	negative selection	949498
57128996	57129019	12	-	26627737	GBM cells	viability after 21 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	-0.17339902659813278	[516]	[270,228]	-1	hSpCas9	negative selection	1031809
57138504	57138527	12	+	26627737	GBM cells	viability after 21 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	0.028551346252852494	[195]	[105,110]	0	hSpCas9	negative selection	1031810
57141442	57141465	12	+	26627737	GBM cells	viability after 21 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	-0.44094940902888213	[214]	[84,86]	-4	hSpCas9	negative selection	1031811
57143683	57143706	12	+	26627737	GBM cells	viability after 21 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	0.1047450957745687	[148]	[85,87]	1	hSpCas9	negative selection	1031812
57149703	57149726	12	+	26627737	GBM cells	viability after 21 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-0.5226468069926873	[336]	[116,136]	-5	hSpCas9	negative selection	1031813
57128996	57129019	12	-	26627737	RPE1	viability after 9 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	-0.4896621435086552	[2802]	[703,522]	-3	hSpCas9	negative selection	1114124
57138504	57138527	12	+	26627737	RPE1	viability after 9 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-0.6550813318391837	[345]	[25,123]	-5	hSpCas9	negative selection	1114125
57141442	57141465	12	+	26627737	RPE1	viability after 9 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	0.2896150716028444	[589]	[206,249]	2	hSpCas9	negative selection	1114126
57143683	57143706	12	+	26627737	RPE1	viability after 9 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	0.5048732565261076	[579]	[306,193]	3	hSpCas9	negative selection	1114127
57149703	57149726	12	+	26627737	RPE1	viability after 9 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-0.08686138090454354	[1452]	[240,669]	0	hSpCas9	negative selection	1114128
57128996	57129019	12	-	26627737	RPE1	viability after 12 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	-0.6482948898957781	[2802]	[581,372]	-4	hSpCas9	negative selection	1196439
57138504	57138527	12	+	26627737	RPE1	viability after 12 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-0.6876602552693962	[345]	[13,103]	-5	hSpCas9	negative selection	1196440
57141442	57141465	12	+	26627737	RPE1	viability after 12 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	-0.9870469779481172	[589]	[78,80]	-6	hSpCas9	negative selection	1196441
57143683	57143706	12	+	26627737	RPE1	viability after 12 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	1.1198839364120634	[579]	[496,170]	6	hSpCas9	negative selection	1196442
57149703	57149726	12	+	26627737	RPE1	viability after 12 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-0.48798832506422185	[1452]	[221,337]	-3	hSpCas9	negative selection	1196443
57128996	57129019	12	-	26627737	RPE1	viability after 15 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	-0.61367596355717	[2802]	[591,446]	-4	hSpCas9	negative selection	1278754
57138504	57138527	12	+	26627737	RPE1	viability after 15 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-1.9838524699426585	[345]	[10,37]	-8	hSpCas9	negative selection	1278755
57141442	57141465	12	+	26627737	RPE1	viability after 15 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	-0.5789395402265101	[589]	[154,69]	-4	hSpCas9	negative selection	1278756
57143683	57143706	12	+	26627737	RPE1	viability after 15 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	0.7435481311931695	[579]	[375,176]	4	hSpCas9	negative selection	1278757
57149703	57149726	12	+	26627737	RPE1	viability after 15 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	0.17762365288402826	[1452]	[471,457]	1	hSpCas9	negative selection	1278758
57128996	57129019	12	-	26627737	RPE1	viability after 18 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	-0.6715919856946171	[2802]	[646,290]	-4	hSpCas9	negative selection	1361069
57138504	57138527	12	+	26627737	RPE1	viability after 18 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-2.6834467049761477	[345]	[0,28]	-9	hSpCas9	negative selection	1361070
57141442	57141465	12	+	26627737	RPE1	viability after 18 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	0.31168849469760307	[589]	[171,224]	2	hSpCas9	negative selection	1361071
57143683	57143706	12	+	26627737	RPE1	viability after 18 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	0.8649131131750849	[579]	[388,173]	5	hSpCas9	negative selection	1361072
57149703	57149726	12	+	26627737	RPE1	viability after 18 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	0.26300917285309167	[1452]	[558,375]	1	hSpCas9	negative selection	1361073
57128996	57129019	12	-	26627737	HeLa	viability after 8 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.1313805055896895	[1270]	[454,557,759]	1	hSpCas9	negative selection	1443384
57138504	57138527	12	+	26627737	HeLa	viability after 8 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	0.2755052410102635	[214]	[157,143,51]	2	hSpCas9	negative selection	1443385
57141442	57141465	12	+	26627737	HeLa	viability after 8 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	-0.4913992858810925	[489]	[299,55,132]	-5	hSpCas9	negative selection	1443386
57143683	57143706	12	+	26627737	HeLa	viability after 8 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	-0.6525225970768699	[577]	[40,225,184]	-6	hSpCas9	negative selection	1443387
57149703	57149726	12	+	26627737	HeLa	viability after 8 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-0.22319451012034053	[700]	[385,291,141]	-2	hSpCas9	negative selection	1443388
57128996	57129019	12	-	26627737	HeLa	viability after 12 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	-0.14654435925494114	[1270]	[661,521,239]	-1	hSpCas9	negative selection	1525699
57138504	57138527	12	+	26627737	HeLa	viability after 12 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-0.4350415571061117	[214]	[84,81,28]	-4	hSpCas9	negative selection	1525700
57141442	57141465	12	+	26627737	HeLa	viability after 12 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	0.01878044055583411	[489]	[370,103,155]	0	hSpCas9	negative selection	1525701
57143683	57143706	12	+	26627737	HeLa	viability after 12 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	-0.1191663048449757	[577]	[97,108,460]	-1	hSpCas9	negative selection	1525702
57149703	57149726	12	+	26627737	HeLa	viability after 12 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-0.3323664422428946	[700]	[362,202,130]	-3	hSpCas9	negative selection	1525703
57128996	57129019	12	-	26627737	HeLa	viability after 15 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.19511788635153238	[1270]	[582,555,641]	1	hSpCas9	negative selection	1608014
57138504	57138527	12	+	26627737	HeLa	viability after 15 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-1.491856629293077	[214]	[52,21,16]	-8	hSpCas9	negative selection	1608015
57141442	57141465	12	+	26627737	HeLa	viability after 15 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	-0.7610737239232287	[489]	[224,41,81]	-6	hSpCas9	negative selection	1608016
57143683	57143706	12	+	26627737	HeLa	viability after 15 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	-0.5742000278071908	[577]	[170,59,249]	-5	hSpCas9	negative selection	1608017
57149703	57149726	12	+	26627737	HeLa	viability after 15 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-0.3197097314261743	[700]	[242,295,139]	-3	hSpCas9	negative selection	1608018
57128996	57129019	12	-	26627737	HeLa	viability after 18 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.20151445962104075	[1270]	[394,461,641]	1	hSpCas9	negative selection	1690329
57138504	57138527	12	+	26627737	HeLa	viability after 18 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-1.3368665627008363	[214]	[40,19,16]	-8	hSpCas9	negative selection	1690330
57141442	57141465	12	+	26627737	HeLa	viability after 18 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	-0.6694596989254664	[489]	[164,35,81]	-5	hSpCas9	negative selection	1690331
57143683	57143706	12	+	26627737	HeLa	viability after 18 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	-0.573640307329091	[577]	[112,51,249]	-5	hSpCas9	negative selection	1690332
57149703	57149726	12	+	26627737	HeLa	viability after 18 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-0.315568918361961	[700]	[161,247,139]	-3	hSpCas9	negative selection	1690333
57128996	57129019	12	-	26627737	HCT116	viability after 6 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.7032117160744089	[1964]	[413,551]	4	hSpCas9	negative selection	1772644
57138504	57138527	12	+	26627737	HCT116	viability after 6 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	0.3164879980486295	[230]	[41,46]	1	hSpCas9	negative selection	1772645
57141442	57141465	12	+	26627737	HCT116	viability after 6 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	-0.7406148879564455	[601]	[84,40]	-4	hSpCas9	negative selection	1772646
57143683	57143706	12	+	26627737	HCT116	viability after 6 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	0.2869566179106187	[658]	[137,119]	1	hSpCas9	negative selection	1772647
57149703	57149726	12	+	26627737	HCT116	viability after 6 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	0.3590599170008679	[719]	[159,136]	2	hSpCas9	negative selection	1772648
57128996	57129019	12	-	26627737	HCT116	viability after 8 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.3629241425718086	[947]	[560,583,865]	4	hSpCas9	negative selection	1854959
57138504	57138527	12	+	26627737	HCT116	viability after 8 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-0.11838055941223691	[124]	[36,98,53]	-1	hSpCas9	negative selection	1854960
57141442	57141465	12	+	26627737	HCT116	viability after 8 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	0.9064152497969202	[131]	[158,162,87]	7	hSpCas9	negative selection	1854961
57143683	57143706	12	+	26627737	HCT116	viability after 8 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	0.3007078307766216	[249]	[130,260,116]	3	hSpCas9	negative selection	1854962
57149703	57149726	12	+	26627737	HCT116	viability after 8 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	0.020924691935718	[390]	[131,282,238]	0	hSpCas9	negative selection	1854963
57128996	57129019	12	-	26627737	HCT116	viability after 9 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.5971966224948309	[1964]	[986,640]	4	hSpCas9	negative selection	1937274
57138504	57138527	12	+	26627737	HCT116	viability after 9 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	0.12397819652536768	[230]	[150,0]	0	hSpCas9	negative selection	1937275
57141442	57141465	12	+	26627737	HCT116	viability after 9 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	-0.1922160114545948	[601]	[176,111]	-1	hSpCas9	negative selection	1937276
57143683	57143706	12	+	26627737	HCT116	viability after 9 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	0.7516252100651118	[658]	[307,286]	5	hSpCas9	negative selection	1937277
57149703	57149726	12	+	26627737	HCT116	viability after 9 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-1.3818075787936284	[719]	[32,105]	-7	hSpCas9	negative selection	1937278
57128996	57129019	12	-	26627737	HCT116	viability after 12 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.25603238617333135	[947]	[551,569,665]	2	hSpCas9	negative selection	2019589
57138504	57138527	12	+	26627737	HCT116	viability after 12 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	0.5318190120322132	[124]	[78,122,84]	5	hSpCas9	negative selection	2019590
57141442	57141465	12	+	26627737	HCT116	viability after 12 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	0.3531054946887019	[131]	[29,89,150]	3	hSpCas9	negative selection	2019591
57143683	57143706	12	+	26627737	HCT116	viability after 12 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	-0.5049633577137632	[249]	[81,105,90]	-5	hSpCas9	negative selection	2019592
57149703	57149726	12	+	26627737	HCT116	viability after 12 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-0.15950883738656574	[390]	[125,265,166]	-2	hSpCas9	negative selection	2019593
57128996	57129019	12	-	26627737	HCT116	viability after 15 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.3027205458031408	[947]	[798,465,763]	3	hSpCas9	negative selection	2101904
57138504	57138527	12	+	26627737	HCT116	viability after 15 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	0.02299649944123172	[124]	[112,62,47]	0	hSpCas9	negative selection	2101905
57141442	57141465	12	+	26627737	HCT116	viability after 15 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	-0.10412567623198088	[131]	[80,72,58]	-1	hSpCas9	negative selection	2101906
57143683	57143706	12	+	26627737	HCT116	viability after 15 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	-0.20920761868995402	[249]	[158,108,108]	-2	hSpCas9	negative selection	2101907
57149703	57149726	12	+	26627737	HCT116	viability after 15 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	0.20979081011220235	[390]	[254,303,219]	2	hSpCas9	negative selection	2101908
57128996	57129019	12	-	26627737	HCT116	viability after 18 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.6033696494858862	[947]	[616,667,810]	5	hSpCas9	negative selection	2184219
57138504	57138527	12	+	26627737	HCT116	viability after 18 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	0.383326804148031	[124]	[72,50,115]	3	hSpCas9	negative selection	2184220
57141442	57141465	12	+	26627737	HCT116	viability after 18 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	0.2348886068848035	[131]	[83,73,66]	2	hSpCas9	negative selection	2184221
57143683	57143706	12	+	26627737	HCT116	viability after 18 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	-0.11021258320914512	[249]	[114,169,43]	-1	hSpCas9	negative selection	2184222
57149703	57149726	12	+	26627737	HCT116	viability after 18 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	1.0971608816138012	[390]	[647,228,344]	8	hSpCas9	negative selection	2184223
57128973	57128996	12	-	24336569	HL60	viability	GCAGCAGCAGGAGCAACGGCGGG	LRP1	ENSG00000123384	-0.561008055439705	[464]	[666]	-5	hSpCas9	negative selection	2275064
57128996	57129019	12	-	24336569	HL60	viability	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	-0.3363391735734298	[1339]	[2245]	-3	hSpCas9	negative selection	2275065
57129010	57129033	12	+	24336569	HL60	viability	CTGGTCGCGGCGGCTATCGACGG	LRP1	ENSG00000123384	0.7274876063630371	[128]	[451]	6	hSpCas9	negative selection	2275066
57138476	57138499	12	-	24336569	HL60	viability	TCTCTGCAGGCAAACTGCTTGGG	LRP1	ENSG00000123384	0.6089476986759897	[210]	[680]	5	hSpCas9	negative selection	2275067
57138489	57138512	12	-	24336569	HL60	viability	ACAGGTTATTTGATCTCTGCAGG	LRP1	ENSG00000123384	-0.4798996325706104	[287]	[436]	-4	hSpCas9	negative selection	2275068
57138499	57138522	12	+	24336569	HL60	viability	TCAAATAACCTGTATCTCAAAGG	LRP1	ENSG00000123384	0.19898098875371695	[754]	[1833]	2	hSpCas9	negative selection	2275069
57138504	57138527	12	+	24336569	HL60	viability	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-0.6974750376092824	[363]	[474]	-6	hSpCas9	negative selection	2275070
57138515	57138538	12	+	24336569	HL60	viability	TCAAAGGGCTGGCGGTGCGACGG	LRP1	ENSG00000123384	0.21536799635146853	[1008]	[2478]	2	hSpCas9	negative selection	2275071
57138522	57138545	12	+	24336569	HL60	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	-0.08731898615945055	[1357]	[2704]	0	hSpCas9	negative selection	2275072
57138536	57138559	12	+	24336569	HL60	viability	GGTGAGAGGGACTGCCCAGACGG	LRP1	ENSG00000123384	0.32483180325836747	[537]	[1425]	3	hSpCas9	negative selection	2275073
57128973	57128996	12	-	24336569	KBM7	viability	GCAGCAGCAGGAGCAACGGCGGG	LRP1	ENSG00000123384	-0.46634622594441777	[618]	[1221]	-4	hSpCas9	negative selection	2342241
57128996	57129019	12	-	24336569	KBM7	viability	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.36201690234123984	[826]	[2898]	3	hSpCas9	negative selection	2342242
57129010	57129033	12	+	24336569	KBM7	viability	CTGGTCGCGGCGGCTATCGACGG	LRP1	ENSG00000123384	-0.15948049889658067	[232]	[568]	-1	hSpCas9	negative selection	2342243
57138476	57138499	12	-	24336569	KBM7	viability	TCTCTGCAGGCAAACTGCTTGGG	LRP1	ENSG00000123384	-0.5207097673883414	[697]	[1326]	-4	hSpCas9	negative selection	2342244
57138489	57138512	12	-	24336569	KBM7	viability	ACAGGTTATTTGATCTCTGCAGG	LRP1	ENSG00000123384	0.2221059830777008	[247]	[788]	2	hSpCas9	negative selection	2342245
57138499	57138522	12	+	24336569	KBM7	viability	TCAAATAACCTGTATCTCAAAGG	LRP1	ENSG00000123384	0.5012333485923279	[458]	[1771]	4	hSpCas9	negative selection	2342246
57138504	57138527	12	+	24336569	KBM7	viability	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-0.12362056643414909	[283]	[710]	-1	hSpCas9	negative selection	2342247
57138515	57138538	12	+	24336569	KBM7	viability	TCAAAGGGCTGGCGGTGCGACGG	LRP1	ENSG00000123384	0.5703427114483799	[619]	[2510]	5	hSpCas9	negative selection	2342248
57138522	57138545	12	+	24336569	KBM7	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.436176132913493	[900]	[3324]	4	hSpCas9	negative selection	2342249
57138536	57138559	12	+	24336569	KBM7	viability	GGTGAGAGGGACTGCCCAGACGG	LRP1	ENSG00000123384	-0.6711098388839283	[316]	[542]	-5	hSpCas9	negative selection	2342250
57128995	57129020	12	+	24717434	HeLa	essential genes for diphteria toxin toxicity	CCCCTGCTCTCAGCTCTGGTCGCGG	LRP1	ENSG00000123384	0.04106198933530188	[2313,2624,2393]	[0,0,0]	0	hSpCas9	positive selection	2381055
57129001	57129023	12	+	24717434	HeLa	essential genes for diphteria toxin toxicity	CTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	-0.24741870652530082	[3215,2748,3019]	[0,0,0]	-2	hSpCas9	positive selection	2381056
57138521	57138545	12	+	24717434	HeLa	essential genes for diphteria toxin toxicity	GGCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	1.5898450199526304	[757,957,787]	[0,0,0]	4	hSpCas9	positive selection	2381057
57128995	57129020	12	+	24717434	HeLa	essential genes for PA/LFnDTA toxicity	CCCCTGCTCTCAGCTCTGGTCGCGG	LRP1	ENSG00000123384	0.040653849385563434	[2313,2624,2393]	[0,0,0]	0	hSpCas9	positive selection	2382319
57129001	57129023	12	+	24717434	HeLa	essential genes for PA/LFnDTA toxicity	CTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	-0.24740228904012468	[3215,2748,3019]	[0,0,0]	-2	hSpCas9	positive selection	2382320
57138521	57138545	12	+	24717434	HeLa	essential genes for PA/LFnDTA toxicity	GGCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	1.5891811159748914	[757,957,787]	[0,0,0]	4	hSpCas9	positive selection	2382321
57182410	57182433	12	-	25494202	A375	resistance to PLX-4720 (puromycin)	TTCAAGTGATTCTCCTGCCTAGG	LRP1	ENSG00000123384	0.04005304646372276	[213,38]	[51,1]	0	dCas9-VP64	positive selection	2478061
57182410	57182433	12	-	25494202	A375	resistance to PLX-4720 (zeocin)	TTCAAGTGATTCTCCTGCCTAGG	LRP1	ENSG00000123384	-0.7043264998708204	[149,257]	[17,60]	-6	dCas9-VP64	positive selection	2573316
57159822	57159845	12	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ACAGGCATCCACAATGTGGAGGG	LRP1	ENSG00000123384	0.20195724533607826	[3,2]	[3,2]	4	hSpCas9	positive selection	2999976
57173154	57173177	12	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ACTGTCCCTCTGCAGCCACGAGG	LRP1	ENSG00000123384	-1.0568587127258433	[2,2]	[1,0]	-9	hSpCas9	positive selection	2999977
57173211	57173234	12	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGATGCATAGTCCATCCAGCCGG	LRP1	ENSG00000123384	-0.15346632759764658	[3,3]	[3,1]	-2	hSpCas9	positive selection	2999978
57159959	57159982	12	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGGCAAAATGACACACCCCAGGG	LRP1	ENSG00000123384	0.138355719422041	[4,3]	[3,3]	3	hSpCas9	positive selection	2999979
57159822	57159845	12	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ACAGGCATCCACAATGTGGAGGG	LRP1	ENSG00000123384	0.03431404471302621	[3,3]	[3,1]	0	hSpCas9	positive selection	3067834
57173154	57173177	12	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ACTGTCCCTCTGCAGCCACGAGG	LRP1	ENSG00000123384	-0.6612837107039449	[2,2]	[1,0]	-8	hSpCas9	positive selection	3067835
57173211	57173234	12	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGATGCATAGTCCATCCAGCCGG	LRP1	ENSG00000123384	0.15004244314738155	[3,3]	[1,3]	2	hSpCas9	positive selection	3067836
57159959	57159982	12	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGGCAAAATGACACACCCCAGGG	LRP1	ENSG00000123384	0.1288968568696718	[4,4]	[4,2]	2	hSpCas9	positive selection	3067837
57138547	57138570		+	24336571	A375	resistance to PLX after 7 days	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	0.26205865532408307	[9,8]	[10,10]	7	hSpCas9	positive selection	3125180
57141402	57141425		+	24336571	A375	resistance to PLX after 7 days	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	-0.17880744842333043	[18,14]	[13,15]	-5	hSpCas9	positive selection	3125181
57138522	57138545		+	24336571	A375	resistance to PLX after 7 days	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	-0.03682613054143408	[7,9]	[7,9]	-1	hSpCas9	positive selection	3125182
57138547	57138570		+	24336571	A375	resistance to PLX after 14 days	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	1.0794606874551047	[6,5]	[7,4]	8	hSpCas9	positive selection	3182973
57141402	57141425		+	24336571	A375	resistance to PLX after 14 days	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	-0.6588150751881738	[13,18]	[3,4]	-7	hSpCas9	positive selection	3182974
57138522	57138545		+	24336571	A375	resistance to PLX after 14 days	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	-0.080646551374422	[8,6]	[3,2]	-1	hSpCas9	positive selection	3182975
57138547	57138570		+	24336571	A375	viability after 7 days	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.09001094770084417	[10]	[9,8]	-1	hSpCas9	negative selection	3240766
57141402	57141425		+	24336571	A375	viability after 7 days	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.5735850477356247	[11]	[18,14]	8	hSpCas9	negative selection	3240767
57138522	57138545		+	24336571	A375	viability after 7 days	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.6658987254844455	[5]	[7,9]	8	hSpCas9	negative selection	3240768
57138547	57138570		+	24336571	A375	viability after 14 days	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.5617849868785504	[10]	[6,5]	-6	hSpCas9	negative selection	3298559
57141402	57141425		+	24336571	A375	viability after 14 days	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.5716720309586505	[11]	[13,18]	7	hSpCas9	negative selection	3298560
57138522	57138545		+	24336571	A375	viability after 14 days	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.455300739009342	[5]	[8,6]	6	hSpCas9	negative selection	3298561
57141402	57141425	12	+	27383988	293T	resistance to West Nile virus (flavivirus)	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	-1.7341956346298601	[508,508]	[0,0]	-9	hSpCas9	positive selection	3377555
57143716	57143739	12	-	27383988	293T	resistance to West Nile virus (flavivirus)	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.5849008694743394	[101,101]	[0,0]	3	hSpCas9	positive selection	3377556
57143717	57143740	12	+	27383988	293T	resistance to West Nile virus (flavivirus)	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.28956824844180157	[186,186]	[0,0]	-2	hSpCas9	positive selection	3377557
57159821	57159844	12	+	26780180	HT29	viability (Avana library 4 designs)	ACAGGCATCCACAATGTGGAGGG	LRP1	ENSG00000123384	1.30790212564648	[]	[]	5	hSpCas9	negative selection	3437545
57173153	57173176	12	+	26780180	HT29	viability (Avana library 4 designs)	ACTGTCCCTCTGCAGCCACGAGG	LRP1	ENSG00000123384	1.16745053932985	[]	[]	4	hSpCas9	negative selection	3437546
57173211	57173234	12	-	26780180	HT29	viability (Avana library 4 designs)	GGATGCATAGTCCATCCAGCCGG	LRP1	ENSG00000123384	1.27206069956996	[]	[]	5	hSpCas9	negative selection	3437547
57159958	57159981	12	+	26780180	HT29	viability (Avana library 4 designs)	GGGCAAAATGACACACCCCAGGG	LRP1	ENSG00000123384	1.20329229998923	[]	[]	5	hSpCas9	negative selection	3437548
57159958	57159981	12	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGGCAAAATGACACACCCCAGGG	LRP1	ENSG00000123384	3.74764106311413	[]	[]	6	hSpCas9	negative selection	3526319
57173153	57173176	12	+	26780180	A375	viability (Avana lentiCRISPRv2)	ACTGTCCCTCTGCAGCCACGAGG	LRP1	ENSG00000123384	3.98343689742965	[]	[]	6	hSpCas9	negative selection	3526320
57159821	57159844	12	+	26780180	A375	viability (Avana lentiCRISPRv2)	ACAGGCATCCACAATGTGGAGGG	LRP1	ENSG00000123384	2.62289626881234	[]	[]	4	hSpCas9	negative selection	3526321
57173211	57173234	12	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGATGCATAGTCCATCCAGCCGG	LRP1	ENSG00000123384	-4.63050511423466	[]	[]	-5	hSpCas9	negative selection	3526322
57159892	57159915	12	+	26780180	A375	viability (Avana lentiCRISPRv2)	GCCCAAAAAGACAATCAGCGTGG	LRP1	ENSG00000123384	-3.82833935346757	[]	[]	-4	hSpCas9	negative selection	3526323
57178535	57178558	12	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGTGTTGGTCCTCTGTACCACGG	LRP1	ENSG00000123384	2.23897389999968	[]	[]	3	hSpCas9	negative selection	3526324
57159958	57159981	12	+	26780180	A375	viability (Avana lentiGuide)	GGGCAAAATGACACACCCCAGGG	LRP1	ENSG00000123384	-6.09502132734465	[]	[]	-9	hSpCas9	negative selection	3634978
57173153	57173176	12	+	26780180	A375	viability (Avana lentiGuide)	ACTGTCCCTCTGCAGCCACGAGG	LRP1	ENSG00000123384	5.78144748115065	[]	[]	5	hSpCas9	negative selection	3634979
57159821	57159844	12	+	26780180	A375	viability (Avana lentiGuide)	ACAGGCATCCACAATGTGGAGGG	LRP1	ENSG00000123384	-1.86072753302323	[]	[]	-3	hSpCas9	negative selection	3634980
57173211	57173234	12	-	26780180	A375	viability (Avana lentiGuide)	GGATGCATAGTCCATCCAGCCGG	LRP1	ENSG00000123384	2.45662813778971	[]	[]	2	hSpCas9	negative selection	3634981
57159892	57159915	12	+	26780180	A375	viability (Avana lentiGuide)	GCCCAAAAAGACAATCAGCGTGG	LRP1	ENSG00000123384	0.232394392965762	[]	[]	0	hSpCas9	negative selection	3634982
57178535	57178558	12	-	26780180	A375	viability (Avana lentiGuide)	GGTGTTGGTCCTCTGTACCACGG	LRP1	ENSG00000123384	0.707615252965086	[]	[]	0	hSpCas9	negative selection	3634983
57159958	57159981	12	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGGCAAAATGACACACCCCAGGG	LRP1	ENSG00000123384	0.07205220032993503	[5]	[5,5]	1	hSpCas9	positive selection	3743637
57173153	57173176	12	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ACTGTCCCTCTGCAGCCACGAGG	LRP1	ENSG00000123384	-0.013779275557771087	[4]	[4,3]	0	hSpCas9	positive selection	3743638
57159821	57159844	12	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ACAGGCATCCACAATGTGGAGGG	LRP1	ENSG00000123384	0.061747343614063366	[4]	[5,4]	1	hSpCas9	positive selection	3743639
57173211	57173234	12	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGATGCATAGTCCATCCAGCCGG	LRP1	ENSG00000123384	-0.2073932220617951	[4]	[4,2]	-3	hSpCas9	positive selection	3743640
57159892	57159915	12	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCCCAAAAAGACAATCAGCGTGG	LRP1	ENSG00000123384	-0.06513049349786598	[5]	[5,4]	-1	hSpCas9	positive selection	3743641
57178535	57178558	12	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGTGTTGGTCCTCTGTACCACGG	LRP1	ENSG00000123384	0.15178035899254494	[6]	[6,6]	4	hSpCas9	positive selection	3743642
57159958	57159981	12	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGGCAAAATGACACACCCCAGGG	LRP1	ENSG00000123384	0.39857984985082073	[5]	[6,6]	9	hSpCas9	positive selection	3852244
57173153	57173176	12	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ACTGTCCCTCTGCAGCCACGAGG	LRP1	ENSG00000123384	-0.5257169485196552	[4]	[2,2]	-6	hSpCas9	positive selection	3852245
57159821	57159844	12	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ACAGGCATCCACAATGTGGAGGG	LRP1	ENSG00000123384	0.0038178787634212674	[4]	[2,4]	0	hSpCas9	positive selection	3852246
57173211	57173234	12	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGATGCATAGTCCATCCAGCCGG	LRP1	ENSG00000123384	-0.2415359980477101	[5]	[3,4]	-3	hSpCas9	positive selection	3852247
57159892	57159915	12	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCCCAAAAAGACAATCAGCGTGG	LRP1	ENSG00000123384	0.15390978927284993	[6]	[6,6]	3	hSpCas9	positive selection	3852248
57178535	57178558	12	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGTGTTGGTCCTCTGTACCACGG	LRP1	ENSG00000123384	0.13768793968655624	[6]	[6,5]	3	hSpCas9	positive selection	3852249
57141500	57141523	12	-	26780180	A375	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	1.38274990429968	[]	[]	7	hSpCas9	negative selection	3957892
57143716	57143739	12	-	26780180	A375	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.331626326390081	[]	[]	0	hSpCas9	negative selection	3957893
57143717	57143740	12	+	26780180	A375	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.781137817661945	[]	[]	3	hSpCas9	negative selection	3957894
57138547	57138570	12	+	26780180	A375	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	1.30421159518682	[]	[]	7	hSpCas9	negative selection	3957895
57141402	57141425	12	+	26780180	A375	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	1.63125583113117	[]	[]	8	hSpCas9	negative selection	3957896
57138522	57138545	12	+	26780180	A375	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.885021525739211	[]	[]	4	hSpCas9	negative selection	3957897
57141500	57141523	12	-	26780180	HT29	viability (GeCKOv2 library)	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	1.08700327242532	[]	[]	5	hSpCas9	negative selection	4065858
57143716	57143739	12	-	26780180	HT29	viability (GeCKOv2 library)	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	1.23292029171923	[]	[]	6	hSpCas9	negative selection	4065859
57143717	57143740	12	+	26780180	HT29	viability (GeCKOv2 library)	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	1.07747488634704	[]	[]	5	hSpCas9	negative selection	4065860
57138547	57138570	12	+	26780180	HT29	viability (GeCKOv2 library)	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	0.782173316016514	[]	[]	3	hSpCas9	negative selection	4065861
57141402	57141425	12	+	26780180	HT29	viability (GeCKOv2 library)	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	1.17267528709606	[]	[]	5	hSpCas9	negative selection	4065862
57138522	57138545	12	+	26780180	HT29	viability (GeCKOv2 library)	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.305065008956336	[]	[]	0	hSpCas9	negative selection	4065863
57138547	57138570	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	0.08608073536828574	[3]	[1,2]	2	hSpCas9	positive selection	4149293
57141402	57141425	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	-0.16249386430188953	[4]	[2,2]	-4	hSpCas9	positive selection	4149294
57138522	57138545	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	-0.2627670878044003	[3]	[1,1]	-6	hSpCas9	positive selection	4149295
57138547	57138570	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.1249706872913716	[4]	[2,1,1,0]	-2	hSpCas9	positive selection	4213315
57141402	57141425	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.9194963039414108	[4]	[1,2,2,4]	6	hSpCas9	positive selection	4213316
57138522	57138545	12	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	-0.19877852969920717	[2]	[0,0,1,0]	-3	hSpCas9	positive selection	4213317
57138547	57138570	12	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	0.24163311276363744	[3]	[2,3]	5	hSpCas9	positive selection	4280856
57141500	57141523	12	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.09713364519644647	[3]	[2,2]	-2	hSpCas9	positive selection	4280857
57138522	57138545	12	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.42304520295138376	[3]	[3,3]	8	hSpCas9	positive selection	4280858
57141402	57141425	12	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.4628701206116492	[4]	[3,4]	8	hSpCas9	positive selection	4345115
57143716	57143739	12	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.43933462735587314	[2]	[2,2]	8	hSpCas9	positive selection	4345116
57143717	57143740	12	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.7038531272679341	[3]	[3,5]	9	hSpCas9	positive selection	4345117
57159871	57159893	12	+	27760321	OCIAML3	viability	TCTGTACTGGACGGACGATGGG	LRP1	ENSG00000123384	-1.1504625002326427	[533,462]	[205,134]	-7	hSpCas9	negative selection	4415117
57161066	57161088	12	-	27760321	OCIAML3	viability	GTCTCGATGCGGTCGTAGAAGG	LRP1	ENSG00000123384	-0.5441120909104512	[477,519]	[278,256]	-5	hSpCas9	negative selection	4415118
57166099	57166121	12	-	27760321	OCIAML3	viability	TCGCACTTGAATCGGTCCGAGG	LRP1	ENSG00000123384	0.641887267586552	[861,735]	[964,980]	7	hSpCas9	negative selection	4415119
57184357	57184379	12	-	27760321	OCIAML3	viability	GCCGAGACCGCTCAATACGCGG	LRP1	ENSG00000123384	0.018847415678581794	[508,415]	[335,401]	0	hSpCas9	negative selection	4415120
57185089	57185111	12	-	27760321	OCIAML3	viability	CCGCGCTTGATAGAGCCGTTGG	LRP1	ENSG00000123384	-0.7332898926129977	[903,675]	[364,372]	-6	hSpCas9	negative selection	4415121
57159871	57159893	12	+	27760321	OCIAML2	viability	TCTGTACTGGACGGACGATGGG	LRP1	ENSG00000123384	-0.21970791385012778	[533,462]	[284,424]	-3	hSpCas9	negative selection	4498580
57161066	57161088	12	-	27760321	OCIAML2	viability	GTCTCGATGCGGTCGTAGAAGG	LRP1	ENSG00000123384	0.0682180242189504	[477,519]	[394,466]	0	hSpCas9	negative selection	4498581
57166099	57166121	12	-	27760321	OCIAML2	viability	TCGCACTTGAATCGGTCCGAGG	LRP1	ENSG00000123384	0.21489645189079287	[861,735]	[736,761]	3	hSpCas9	negative selection	4498582
57184357	57184379	12	-	27760321	OCIAML2	viability	GCCGAGACCGCTCAATACGCGG	LRP1	ENSG00000123384	0.3787434160673477	[508,415]	[351,657]	5	hSpCas9	negative selection	4498583
57185089	57185111	12	-	27760321	OCIAML2	viability	CCGCGCTTGATAGAGCCGTTGG	LRP1	ENSG00000123384	-0.34304271162021055	[903,675]	[464,544]	-4	hSpCas9	negative selection	4498584
57159871	57159893	12	+	27760321	MV411	viability	TCTGTACTGGACGGACGATGGG	LRP1	ENSG00000123384	-1.4733609574130964	[533,462]	[80,173]	-7	hSpCas9	negative selection	4582043
57161066	57161088	12	-	27760321	MV411	viability	GTCTCGATGCGGTCGTAGAAGG	LRP1	ENSG00000123384	0.3062992764850964	[477,519]	[315,550]	2	hSpCas9	negative selection	4582044
57166099	57166121	12	-	27760321	MV411	viability	TCGCACTTGAATCGGTCCGAGG	LRP1	ENSG00000123384	0.7582172311136076	[861,735]	[846,951]	5	hSpCas9	negative selection	4582045
57184357	57184379	12	-	27760321	MV411	viability	GCCGAGACCGCTCAATACGCGG	LRP1	ENSG00000123384	-0.28380243308087755	[508,415]	[75,509]	-2	hSpCas9	negative selection	4582046
57185089	57185111	12	-	27760321	MV411	viability	CCGCGCTTGATAGAGCCGTTGG	LRP1	ENSG00000123384	-1.0112630026706575	[903,675]	[279,220]	-6	hSpCas9	negative selection	4582047
57159871	57159893	12	+	27760321	HL60	viability	TCTGTACTGGACGGACGATGGG	LRP1	ENSG00000123384	0.3341535093540063	[533,462]	[479,545]	4	hSpCas9	negative selection	4665506
57161066	57161088	12	-	27760321	HL60	viability	GTCTCGATGCGGTCGTAGAAGG	LRP1	ENSG00000123384	0.1976141669107097	[477,519]	[407,536]	2	hSpCas9	negative selection	4665507
57166099	57166121	12	-	27760321	HL60	viability	TCGCACTTGAATCGGTCCGAGG	LRP1	ENSG00000123384	0.8298796013551991	[861,735]	[1254,1051]	8	hSpCas9	negative selection	4665508
57184357	57184379	12	-	27760321	HL60	viability	GCCGAGACCGCTCAATACGCGG	LRP1	ENSG00000123384	0.25308088217150143	[508,415]	[464,429]	3	hSpCas9	negative selection	4665509
57185089	57185111	12	-	27760321	HL60	viability	CCGCGCTTGATAGAGCCGTTGG	LRP1	ENSG00000123384	-0.12220326605943543	[903,675]	[648,522]	-1	hSpCas9	negative selection	4665510
57159871	57159893	12	+	27760321	HT1080	viability	TCTGTACTGGACGGACGATGGG	LRP1	ENSG00000123384	-0.44031429589797844	[462,360]	[140,98]	-2	hSpCas9	negative selection	4748969
57161066	57161088	12	-	27760321	HT1080	viability	GTCTCGATGCGGTCGTAGAAGG	LRP1	ENSG00000123384	1.5191155788569743	[519,405]	[647,397]	8	hSpCas9	negative selection	4748970
57166099	57166121	12	-	27760321	HT1080	viability	TCGCACTTGAATCGGTCCGAGG	LRP1	ENSG00000123384	-0.11360542288534681	[735,574]	[185,301]	0	hSpCas9	negative selection	4748971
57184357	57184379	12	-	27760321	HT1080	viability	GCCGAGACCGCTCAATACGCGG	LRP1	ENSG00000123384	0.191136404364189	[415,324]	[210,121]	0	hSpCas9	negative selection	4748972
57185089	57185111	12	-	27760321	HT1080	viability	CCGCGCTTGATAGAGCCGTTGG	LRP1	ENSG00000123384	0.30314033030737364	[675,527]	[293,297]	1	hSpCas9	negative selection	4748973
57159871	57159893	12	+	27760321	HT29	viability after 7 days	TCTGTACTGGACGGACGATGGG	LRP1	ENSG00000123384	-0.2398530359430672	[462,360]	[490,377,480]	-3	hSpCas9	negative selection	4832432
57161066	57161088	12	-	27760321	HT29	viability after 7 days	GTCTCGATGCGGTCGTAGAAGG	LRP1	ENSG00000123384	-0.2733158742601108	[519,405]	[497,558,422]	-4	hSpCas9	negative selection	4832433
57166099	57166121	12	-	27760321	HT29	viability after 7 days	TCGCACTTGAATCGGTCCGAGG	LRP1	ENSG00000123384	0.0169165700751559	[735,574]	[1033,729,819]	0	hSpCas9	negative selection	4832434
57184357	57184379	12	-	27760321	HT29	viability after 7 days	GCCGAGACCGCTCAATACGCGG	LRP1	ENSG00000123384	0.5458967680020317	[415,324]	[870,623,617]	8	hSpCas9	negative selection	4832435
57185089	57185111	12	-	27760321	HT29	viability after 7 days	CCGCGCTTGATAGAGCCGTTGG	LRP1	ENSG00000123384	0.03921680962661833	[675,527]	[880,715,799]	0	hSpCas9	negative selection	4832436
57159871	57159893	12	+	27760321	HT29	viability after 25 days	TCTGTACTGGACGGACGATGGG	LRP1	ENSG00000123384	-0.38214026446878724	[462,360]	[391,295,396]	-4	hSpCas9	negative selection	4915895
57161066	57161088	12	-	27760321	HT29	viability after 25 days	GTCTCGATGCGGTCGTAGAAGG	LRP1	ENSG00000123384	-0.839790157304474	[519,405]	[207,284,410]	-6	hSpCas9	negative selection	4915896
57166099	57166121	12	-	27760321	HT29	viability after 25 days	TCGCACTTGAATCGGTCCGAGG	LRP1	ENSG00000123384	0.4094111866783404	[735,574]	[786,1012,1219]	4	hSpCas9	negative selection	4915897
57184357	57184379	12	-	27760321	HT29	viability after 25 days	GCCGAGACCGCTCAATACGCGG	LRP1	ENSG00000123384	0.7314362775134572	[415,324]	[461,649,1046]	8	hSpCas9	negative selection	4915898
57185089	57185111	12	-	27760321	HT29	viability after 25 days	CCGCGCTTGATAGAGCCGTTGG	LRP1	ENSG00000123384	0.0727931998818323	[675,527]	[781,574,818]	0	hSpCas9	negative selection	4915899
57159871	57159893	12	+	27760321	HT29	viability after 22 days	TCTGTACTGGACGGACGATGGG	LRP1	ENSG00000123384	0.15362741362502783	[462,360]	[556,352,679]	1	hSpCas9	negative selection	4999358
57161066	57161088	12	-	27760321	HT29	viability after 22 days	GTCTCGATGCGGTCGTAGAAGG	LRP1	ENSG00000123384	-0.46491731726058344	[519,405]	[317,384,462]	-4	hSpCas9	negative selection	4999359
57166099	57166121	12	-	27760321	HT29	viability after 22 days	TCGCACTTGAATCGGTCCGAGG	LRP1	ENSG00000123384	0.33957453040987595	[735,574]	[735,1067,1079]	3	hSpCas9	negative selection	4999360
57184357	57184379	12	-	27760321	HT29	viability after 22 days	GCCGAGACCGCTCAATACGCGG	LRP1	ENSG00000123384	0.7194216051309935	[415,324]	[819,555,736]	7	hSpCas9	negative selection	4999361
57185089	57185111	12	-	27760321	HT29	viability after 22 days	CCGCGCTTGATAGAGCCGTTGG	LRP1	ENSG00000123384	6.9591902564059e-05	[675,527]	[589,894,604]	0	hSpCas9	negative selection	4999362
57159871	57159893	12	+	27760321	HT29	viability after 19 days	TCTGTACTGGACGGACGATGGG	LRP1	ENSG00000123384	0.10589304120929885	[462,360]	[527,621,377]	0	hSpCas9	negative selection	5082821
57161066	57161088	12	-	27760321	HT29	viability after 19 days	GTCTCGATGCGGTCGTAGAAGG	LRP1	ENSG00000123384	-0.5441791905454827	[519,405]	[491,416,199]	-5	hSpCas9	negative selection	5082822
57166099	57166121	12	-	27760321	HT29	viability after 19 days	TCGCACTTGAATCGGTCCGAGG	LRP1	ENSG00000123384	0.3994917692444103	[735,574]	[852,925,1165]	4	hSpCas9	negative selection	5082823
57184357	57184379	12	-	27760321	HT29	viability after 19 days	GCCGAGACCGCTCAATACGCGG	LRP1	ENSG00000123384	1.3117671268866546	[415,324]	[507,1022,1547]	9	hSpCas9	negative selection	5082824
57185089	57185111	12	-	27760321	HT29	viability after 19 days	CCGCGCTTGATAGAGCCGTTGG	LRP1	ENSG00000123384	0.06854388237479947	[675,527]	[1116,717,384]	0	hSpCas9	negative selection	5082825
57159871	57159893	12	+	27760321	HT29	viability after 16 days	TCTGTACTGGACGGACGATGGG	LRP1	ENSG00000123384	-0.6101926601826188	[462,360]	[305,270,329]	-5	hSpCas9	negative selection	5166284
57161066	57161088	12	-	27760321	HT29	viability after 16 days	GTCTCGATGCGGTCGTAGAAGG	LRP1	ENSG00000123384	-0.7617511595831401	[519,405]	[199,325,379]	-6	hSpCas9	negative selection	5166285
57166099	57166121	12	-	27760321	HT29	viability after 16 days	TCGCACTTGAATCGGTCCGAGG	LRP1	ENSG00000123384	0.33903253884895534	[735,574]	[810,772,1191]	4	hSpCas9	negative selection	5166286
57184357	57184379	12	-	27760321	HT29	viability after 16 days	GCCGAGACCGCTCAATACGCGG	LRP1	ENSG00000123384	0.14969119750102056	[415,324]	[497,502,380]	1	hSpCas9	negative selection	5166287
57185089	57185111	12	-	27760321	HT29	viability after 16 days	CCGCGCTTGATAGAGCCGTTGG	LRP1	ENSG00000123384	-0.06013727806670177	[675,527]	[545,515,869]	0	hSpCas9	negative selection	5166288
57159871	57159893	12	+	27760321	HT29	viability after 13 days	TCTGTACTGGACGGACGATGGG	LRP1	ENSG00000123384	-0.678712712124695	[462,360]	[233,263,391]	-6	hSpCas9	negative selection	5249747
57161066	57161088	12	-	27760321	HT29	viability after 13 days	GTCTCGATGCGGTCGTAGAAGG	LRP1	ENSG00000123384	-0.43647456776209637	[519,405]	[310,416,458]	-5	hSpCas9	negative selection	5249748
57166099	57166121	12	-	27760321	HT29	viability after 13 days	TCGCACTTGAATCGGTCCGAGG	LRP1	ENSG00000123384	0.5473083682844427	[735,574]	[1324,924,1084]	7	hSpCas9	negative selection	5249749
57184357	57184379	12	-	27760321	HT29	viability after 13 days	GCCGAGACCGCTCAATACGCGG	LRP1	ENSG00000123384	0.6228200321926939	[415,324]	[580,626,770]	7	hSpCas9	negative selection	5249750
57185089	57185111	12	-	27760321	HT29	viability after 13 days	CCGCGCTTGATAGAGCCGTTGG	LRP1	ENSG00000123384	-0.23774001765085384	[675,527]	[594,677,508]	-3	hSpCas9	negative selection	5249751
57159871	57159893	12	+	27760321	HT29	viability after 10 days	TCTGTACTGGACGGACGATGGG	LRP1	ENSG00000123384	-0.1934142898115439	[462,360]	[523,447,378]	-3	hSpCas9	negative selection	5333210
57161066	57161088	12	-	27760321	HT29	viability after 10 days	GTCTCGATGCGGTCGTAGAAGG	LRP1	ENSG00000123384	-0.2717996725851464	[519,405]	[450,402,577]	-3	hSpCas9	negative selection	5333211
57166099	57166121	12	-	27760321	HT29	viability after 10 days	TCGCACTTGAATCGGTCCGAGG	LRP1	ENSG00000123384	0.22463844455127002	[735,574]	[756,1065,1046]	3	hSpCas9	negative selection	5333212
57184357	57184379	12	-	27760321	HT29	viability after 10 days	GCCGAGACCGCTCAATACGCGG	LRP1	ENSG00000123384	0.8766513573133762	[415,324]	[968,953,632]	9	hSpCas9	negative selection	5333213
57185089	57185111	12	-	27760321	HT29	viability after 10 days	CCGCGCTTGATAGAGCCGTTGG	LRP1	ENSG00000123384	0.05007708505748387	[675,527]	[853,753,726]	0	hSpCas9	negative selection	5333214
57159871	57159893	12	+	27760321	MOLM13	viability	TCTGTACTGGACGGACGATGGG	LRP1	ENSG00000123384	-0.3591858764536937	[533,462]	[141,283]	-2	hSpCas9	negative selection	5416673
57161066	57161088	12	-	27760321	MOLM13	viability	GTCTCGATGCGGTCGTAGAAGG	LRP1	ENSG00000123384	0.13407008451126057	[477,519]	[202,402]	0	hSpCas9	negative selection	5416674
57166099	57166121	12	-	27760321	MOLM13	viability	TCGCACTTGAATCGGTCCGAGG	LRP1	ENSG00000123384	0.45886304885387397	[861,735]	[958,326]	3	hSpCas9	negative selection	5416675
57184357	57184379	12	-	27760321	MOLM13	viability	GCCGAGACCGCTCAATACGCGG	LRP1	ENSG00000123384	-0.10280571380334377	[508,415]	[89,370]	0	hSpCas9	negative selection	5416676
57185089	57185111	12	-	27760321	MOLM13	viability	CCGCGCTTGATAGAGCCGTTGG	LRP1	ENSG00000123384	-0.5241439798981665	[903,675]	[363,258]	-3	hSpCas9	negative selection	5416677
57128881	57128904	12	+	27661255	K562	viability	GGGGGACCCCCCAACTGGGGGGG	LRP1	ENSG00000123384	0.1255671977277979	[125,152]	[125,116]	4	dCas9-KRAB	negative selection	5490871
57128550	57128573	12	-	27661255	K562	viability	GGGGCTTGATGGAGCTCTGGGGG	LRP1	ENSG00000123384	0.047645451900910185	[1572,1939]	[1515,1383]	1	dCas9-KRAB	negative selection	5490872
57138547	57138570	12	+	27260156	BXPC3	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.1996823965620733	[631]	[571,577,477,680]	-4	hSpCas9	negative selection	5553316
57141500	57141523	12	-	27260156	BXPC3	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.07523414920114546	[783]	[644,784,860,838]	-2	hSpCas9	negative selection	5553317
57138522	57138545	12	+	27260156	BXPC3	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.40599837823445956	[471]	[508,655,707,768]	8	hSpCas9	negative selection	5553318
57141402	57141425	12	+	27260156	BXPC3	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	-0.013545312906603213	[1029]	[1042,1015,1114,1095]	0	hSpCas9	negative selection	5617575
57143716	57143739	12	-	27260156	BXPC3	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.07731138391688525	[361]	[336,290,485,508]	1	hSpCas9	negative selection	5617576
57143717	57143740	12	+	27260156	BXPC3	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.031246006992039832	[572]	[655,507,545,632]	0	hSpCas9	negative selection	5617577
57138547	57138570	12	+	27260156	A673	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.03394199912508511	[631]	[775,592,891,706]	-1	hSpCas9	negative selection	5674567
57141500	57141523	12	-	27260156	A673	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.19869227105922027	[783]	[872,683,840,894]	-5	hSpCas9	negative selection	5674568
57138522	57138545	12	+	27260156	A673	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.2121559449557774	[471]	[753,688,569,620]	5	hSpCas9	negative selection	5674569
57141402	57141425	12	+	27260156	A673	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.09385584218073206	[1029]	[1484,1234,1283,1292]	2	hSpCas9	negative selection	5738826
57143716	57143739	12	-	27260156	A673	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.048848896636098205	[361]	[552,480,367,404]	1	hSpCas9	negative selection	5738827
57143717	57143740	12	+	27260156	A673	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.02216723905591822	[572]	[653,622,755,759]	0	hSpCas9	negative selection	5738828
57138547	57138570	12	+	27260156	A375	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.13568277632292997	[631]	[581,763,686,664]	-2	hSpCas9	negative selection	5795818
57141500	57141523	12	-	27260156	A375	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.06696633550746167	[783]	[867,908,910,816]	-1	hSpCas9	negative selection	5795819
57138522	57138545	12	+	27260156	A375	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.39923776351780305	[471]	[777,867,613,671]	6	hSpCas9	negative selection	5795820
57141402	57141425	12	+	27260156	A375	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.22402291153115317	[1029]	[1137,1896,1338,1317]	3	hSpCas9	negative selection	5860077
57143716	57143739	12	-	27260156	A375	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.02875885654512983	[361]	[324,643,412,376]	0	hSpCas9	negative selection	5860078
57143717	57143740	12	+	27260156	A375	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.22190783498489874	[572]	[912,795,759,666]	3	hSpCas9	negative selection	5860079
57138547	57138570	12	+	27260156	COLO741	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.5479688517050988	[631]	[686,512,472]	-8	hSpCas9	negative selection	5917069
57141500	57141523	12	-	27260156	COLO741	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.22125585710295093	[783]	[1027,884,689]	-5	hSpCas9	negative selection	5917070
57138522	57138545	12	+	27260156	COLO741	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.11744459146606426	[471]	[664,543,745]	2	hSpCas9	negative selection	5917071
57141402	57141425	12	+	27260156	COLO741	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.1198635245240316	[1029]	[1753,1439,1141]	2	hSpCas9	negative selection	5981328
57143716	57143739	12	-	27260156	COLO741	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.01198315202278516	[361]	[549,392,440]	0	hSpCas9	negative selection	5981329
57143717	57143740	12	+	27260156	COLO741	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.07985722416254554	[572]	[906,779,652]	1	hSpCas9	negative selection	5981330
57138547	57138570	12	+	27260156	CAL120	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.4565273911026103	[631]	[595,633,493]	-6	hSpCas9	negative selection	6038320
57141500	57141523	12	-	27260156	CAL120	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.22997192888636275	[783]	[579,804,1067]	-3	hSpCas9	negative selection	6038321
57138522	57138545	12	+	27260156	CAL120	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.7580444368636339	[471]	[1297,990,740]	9	hSpCas9	negative selection	6038322
57141402	57141425	12	+	27260156	CAL120	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.0974898519717291	[1029]	[1103,1419,1545]	1	hSpCas9	negative selection	6102579
57143716	57143739	12	-	27260156	CAL120	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.14693392677052386	[361]	[422,291,505]	-2	hSpCas9	negative selection	6102580
57143717	57143740	12	+	27260156	CAL120	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.19308861310052738	[572]	[795,706,936]	3	hSpCas9	negative selection	6102581
57138547	57138570	12	+	27260156	CADOES1	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.1956611585774547	[631]	[455,553,560,480]	-3	hSpCas9	negative selection	6159571
57141500	57141523	12	-	27260156	CADOES1	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.13706224038423132	[783]	[533,638,728,753]	-2	hSpCas9	negative selection	6159572
57138522	57138545	12	+	27260156	CADOES1	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.40237509717162445	[471]	[664,549,640,459]	6	hSpCas9	negative selection	6159573
57141402	57141425	12	+	27260156	CADOES1	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.2952134457104585	[1029]	[1197,1108,1211,1182]	5	hSpCas9	negative selection	6223830
57143716	57143739	12	-	27260156	CADOES1	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.07405338716480564	[361]	[257,429,376,352]	1	hSpCas9	negative selection	6223831
57143717	57143740	12	+	27260156	CADOES1	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.18904913031380538	[572]	[498,649,533,752]	3	hSpCas9	negative selection	6223832
57138547	57138570	12	+	27260156	EWS502	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.5298491692058417	[631]	[329,376,590,584]	-7	hSpCas9	negative selection	6280822
57141500	57141523	12	-	27260156	EWS502	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.31097416470957073	[783]	[695,579,797,597]	-5	hSpCas9	negative selection	6280823
57138522	57138545	12	+	27260156	EWS502	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.08421988291385392	[471]	[410,588,518,616]	1	hSpCas9	negative selection	6280824
57141402	57141425	12	+	27260156	EWS502	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.3287385361146973	[1029]	[1306,1410,1241,1530]	6	hSpCas9	negative selection	6345081
57143716	57143739	12	-	27260156	EWS502	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.10812645311895186	[361]	[188,482,318,451]	-2	hSpCas9	negative selection	6345082
57143717	57143740	12	+	27260156	EWS502	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.16348241288558552	[572]	[487,385,547,772]	-3	hSpCas9	negative selection	6345083
57138547	57138570	12	+	27260156	EW8	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.5867427944813004	[631]	[348,356,323,336]	-8	hSpCas9	negative selection	6402073
57141500	57141523	12	-	27260156	EW8	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.32195642998866947	[783]	[602,630,377,452]	-5	hSpCas9	negative selection	6402074
57138522	57138545	12	+	27260156	EW8	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.2536106873901856	[471]	[431,423,388,585]	4	hSpCas9	negative selection	6402075
57141402	57141425	12	+	27260156	EW8	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.090662809975812	[1029]	[884,813,863,992]	1	hSpCas9	negative selection	6466332
57143716	57143739	12	-	27260156	EW8	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.16514783515407566	[361]	[346,237,407,309]	3	hSpCas9	negative selection	6466333
57143717	57143740	12	+	27260156	EW8	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.053270345331239394	[572]	[454,456,421,459]	-1	hSpCas9	negative selection	6466334
57138547	57138570	12	+	27260156	CORL105	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.38559296786568725	[631]	[522,561,668,525]	-6	hSpCas9	negative selection	6523324
57141500	57141523	12	-	27260156	CORL105	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.0028599346310889118	[783]	[807,808,1239,855]	0	hSpCas9	negative selection	6523325
57138522	57138545	12	+	27260156	CORL105	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.48891194031053176	[471]	[551,922,789,827]	8	hSpCas9	negative selection	6523326
57141402	57141425	12	+	27260156	CORL105	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.196087083327247	[1029]	[1408,1181,1530,1430]	3	hSpCas9	negative selection	6587583
57143716	57143739	12	-	27260156	CORL105	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.10087649751079542	[361]	[455,301,411,416]	-2	hSpCas9	negative selection	6587584
57143717	57143740	12	+	27260156	CORL105	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.06732225806869979	[572]	[780,575,645,803]	1	hSpCas9	negative selection	6587585
57138547	57138570	12	+	27260156	HS294T	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	0.008261120352219264	[631]	[203,371,184,215]	0	hSpCas9	negative selection	6644575
57141500	57141523	12	-	27260156	HS294T	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	0.12391090789751791	[783]	[293,305,336,398]	1	hSpCas9	negative selection	6644576
57138522	57138545	12	+	27260156	HS294T	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.4273753902228188	[471]	[181,239,325,237]	6	hSpCas9	negative selection	6644577
57141402	57141425	12	+	27260156	HS294T	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.4403053475544354	[1029]	[480,528,664,480]	6	hSpCas9	negative selection	6708834
57143716	57143739	12	-	27260156	HS294T	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.18686080746450565	[361]	[179,154,174,117]	2	hSpCas9	negative selection	6708835
57143717	57143740	12	+	27260156	HS294T	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.30441628401850074	[572]	[115,163,237,210]	-4	hSpCas9	negative selection	6708836
57138547	57138570	12	+	27260156	HCC44	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.30488084241122393	[631]	[674,457,807,438]	-5	hSpCas9	negative selection	6765826
57141500	57141523	12	-	27260156	HCC44	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	0.2255505411662414	[783]	[1057,1014,1359,774]	3	hSpCas9	negative selection	6765827
57138522	57138545	12	+	27260156	HCC44	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.6586446427705952	[471]	[1012,531,1065,850]	9	hSpCas9	negative selection	6765828
57141402	57141425	12	+	27260156	HCC44	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.3261339859261403	[1029]	[1910,891,1748,1449]	5	hSpCas9	negative selection	6830085
57143716	57143739	12	-	27260156	HCC44	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.11211511775903743	[361]	[360,317,551,319]	-2	hSpCas9	negative selection	6830086
57143717	57143740	12	+	27260156	HCC44	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.06182689760022453	[572]	[899,420,628,584]	-1	hSpCas9	negative selection	6830087
57138547	57138570	12	+	27260156	G402	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	0.041955809849978376	[631]	[637,657,687,1140]	0	hSpCas9	negative selection	6887077
57141500	57141523	12	-	27260156	G402	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.41632883835147755	[783]	[688,897,586,697]	-5	hSpCas9	negative selection	6887078
57138522	57138545	12	+	27260156	G402	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.6684797134335937	[471]	[1242,604,896,940]	8	hSpCas9	negative selection	6887079
57141402	57141425	12	+	27260156	G402	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.2929288745047589	[1029]	[1755,1642,1500,1301]	3	hSpCas9	negative selection	6951336
57143716	57143739	12	-	27260156	G402	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.12406705177953592	[361]	[341,267,638,355]	-1	hSpCas9	negative selection	6951337
57143717	57143740	12	+	27260156	G402	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.25662512129864357	[572]	[471,1193,840,800]	3	hSpCas9	negative selection	6951338
57138547	57138570	12	+	27260156	L33	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.18751763090538223	[631]	[653,232,312,496]	-4	hSpCas9	negative selection	7008328
57141500	57141523	12	-	27260156	L33	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	0.1326027272612028	[783]	[920,305,493,980]	3	hSpCas9	negative selection	7008329
57138522	57138545	12	+	27260156	L33	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.19848160858414512	[471]	[445,261,352,521]	4	hSpCas9	negative selection	7008330
57141402	57141425	12	+	27260156	L33	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.011520772763962794	[1029]	[1140,396,694,935]	0	hSpCas9	negative selection	7072587
57143716	57143739	12	-	27260156	L33	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.043326090772151715	[361]	[435,150,237,307]	1	hSpCas9	negative selection	7072588
57143717	57143740	12	+	27260156	L33	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.10392394604664199	[572]	[496,225,302,601]	-2	hSpCas9	negative selection	7072589
57138547	57138570	12	+	27260156	K562	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.21342565632802163	[631]	[412,451,638,427]	-3	hSpCas9	negative selection	7129579
57141500	57141523	12	-	27260156	K562	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.1509710377289527	[783]	[631,785,650,462]	-2	hSpCas9	negative selection	7129580
57138522	57138545	12	+	27260156	K562	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.3986261005536327	[471]	[438,631,886,275]	5	hSpCas9	negative selection	7129581
57141402	57141425	12	+	27260156	K562	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.29714782296227993	[1029]	[1134,818,1483,1043]	4	hSpCas9	negative selection	7193838
57143716	57143739	12	-	27260156	K562	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.21159928022005026	[361]	[237,244,365,256]	-3	hSpCas9	negative selection	7193839
57143717	57143740	12	+	27260156	K562	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.6411285907859015	[572]	[1376,437,1024,403]	7	hSpCas9	negative selection	7193840
57138547	57138570	12	+	27260156	HT29	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.0687153070084694	[631]	[738,863,631,704]	-1	hSpCas9	negative selection	7250830
57141500	57141523	12	-	27260156	HT29	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.08218624610744463	[783]	[1095,993,720,816]	-2	hSpCas9	negative selection	7250831
57138522	57138545	12	+	27260156	HT29	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.13802548468449582	[471]	[714,831,522,491]	2	hSpCas9	negative selection	7250832
57141402	57141425	12	+	27260156	HT29	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.15711316848127455	[1029]	[1175,1319,1551,1490]	3	hSpCas9	negative selection	7315089
57143716	57143739	12	-	27260156	HT29	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.19577084552643753	[361]	[427,334,482,297]	-4	hSpCas9	negative selection	7315090
57143717	57143740	12	+	27260156	HT29	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.06005122156247583	[572]	[837,881,714,512]	1	hSpCas9	negative selection	7315091
57138547	57138570	12	+	27260156	MHHES1	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.4093396061583624	[631]	[547,673,479,461]	-6	hSpCas9	negative selection	7372081
57141500	57141523	12	-	27260156	MHHES1	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.10369242667000056	[783]	[1297,647,725,670]	-2	hSpCas9	negative selection	7372082
57138522	57138545	12	+	27260156	MHHES1	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.15456493894931245	[471]	[543,859,533,465]	3	hSpCas9	negative selection	7372083
57141402	57141425	12	+	27260156	MHHES1	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.04348753051774512	[1029]	[1101,1322,1248,1103]	0	hSpCas9	negative selection	7436340
57143716	57143739	12	-	27260156	MHHES1	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.159494964214516	[361]	[439,559,555,300]	3	hSpCas9	negative selection	7436341
57143717	57143740	12	+	27260156	MHHES1	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.28159386040420775	[572]	[340,773,549,463]	-5	hSpCas9	negative selection	7436342
57138547	57138570	12	+	27260156	MEWO	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.13879490083766233	[631]	[806,394,461]	-3	hSpCas9	negative selection	7493332
57141500	57141523	12	-	27260156	MEWO	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	0.012703716994893588	[783]	[868,685,689]	0	hSpCas9	negative selection	7493333
57138522	57138545	12	+	27260156	MEWO	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.020174347157853233	[471]	[547,390,423]	0	hSpCas9	negative selection	7493334
57141402	57141425	12	+	27260156	MEWO	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	-0.0633889466458597	[1029]	[947,800,1022]	-1	hSpCas9	negative selection	7557591
57143716	57143739	12	-	27260156	MEWO	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.021933732069913947	[361]	[479,319,257]	0	hSpCas9	negative selection	7557592
57143717	57143740	12	+	27260156	MEWO	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.10764667385153193	[572]	[675,526,548]	2	hSpCas9	negative selection	7557593
57138547	57138570	12	+	27260156	LNCAPCLONEFGC	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.4005709669847515	[631]	[533,417,368,402]	-6	hSpCas9	negative selection	7614583
57141500	57141523	12	-	27260156	LNCAPCLONEFGC	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.011820308123614787	[783]	[857,558,685,717]	0	hSpCas9	negative selection	7614584
57138522	57138545	12	+	27260156	LNCAPCLONEFGC	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.40137679370968116	[471]	[708,465,704,402]	6	hSpCas9	negative selection	7614585
57141402	57141425	12	+	27260156	LNCAPCLONEFGC	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.28857960013906014	[1029]	[1139,943,1363,1155]	4	hSpCas9	negative selection	7678842
57143716	57143739	12	-	27260156	LNCAPCLONEFGC	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.08570819913711242	[361]	[300,250,414,441]	1	hSpCas9	negative selection	7678843
57143717	57143740	12	+	27260156	LNCAPCLONEFGC	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.10547877141254908	[572]	[580,550,656,458]	1	hSpCas9	negative selection	7678844
57138547	57138570	12	+	27260156	PANC0327	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.38075676979018475	[631]	[259,573,375,481]	-5	hSpCas9	negative selection	7735834
57141500	57141523	12	-	27260156	PANC0327	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.5152637782464876	[783]	[426,407,432,685]	-6	hSpCas9	negative selection	7735835
57138522	57138545	12	+	27260156	PANC0327	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.3566671249243637	[471]	[439,418,763,531]	5	hSpCas9	negative selection	7735836
57141402	57141425	12	+	27260156	PANC0327	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.037588849665206814	[1029]	[1306,773,627,1097]	0	hSpCas9	negative selection	7800093
57143716	57143739	12	-	27260156	PANC0327	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.0012754207484260704	[361]	[433,293,384,184]	0	hSpCas9	negative selection	7800094
57143717	57143740	12	+	27260156	PANC0327	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.06723126875888341	[572]	[545,346,564,699]	1	hSpCas9	negative selection	7800095
57138547	57138570	12	+	27260156	NCIH2009	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	0.07613094300417961	[631]	[896,780,1108]	1	hSpCas9	negative selection	7857085
57141500	57141523	12	-	27260156	NCIH2009	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.3260195892251032	[783]	[1142,827,702]	-4	hSpCas9	negative selection	7857086
57138522	57138545	12	+	27260156	NCIH2009	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.7327415225080803	[471]	[1026,829,1419]	8	hSpCas9	negative selection	7857087
57141402	57141425	12	+	27260156	NCIH2009	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.20051933508436548	[1029]	[2822,1393,976]	2	hSpCas9	negative selection	7921344
57143716	57143739	12	-	27260156	NCIH2009	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.550856824541875	[361]	[748,637,837]	7	hSpCas9	negative selection	7921345
57143717	57143740	12	+	27260156	NCIH2009	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.2955449282275171	[572]	[973,892,1078]	4	hSpCas9	negative selection	7921346
57138547	57138570	12	+	27260156	NCIH1373	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.5795470403172724	[631]	[523,586,424,90]	-5	hSpCas9	negative selection	7978336
57141500	57141523	12	-	27260156	NCIH1373	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.43677402661413234	[783]	[534,920,334,201]	-4	hSpCas9	negative selection	7978337
57138522	57138545	12	+	27260156	NCIH1373	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.5687618489154831	[471]	[730,602,987,215]	5	hSpCas9	negative selection	7978338
57141402	57141425	12	+	27260156	NCIH1373	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.22700485726061204	[1029]	[1835,1077,1166,375]	2	hSpCas9	negative selection	8042595
57143716	57143739	12	-	27260156	NCIH1373	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.4098507829055682	[361]	[433,349,191,67]	-4	hSpCas9	negative selection	8042596
57143717	57143740	12	+	27260156	NCIH1373	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.1556099041066816	[572]	[939,380,392,177]	-1	hSpCas9	negative selection	8042597
57138547	57138570	12	+	27260156	PATU8902	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.1904863232711212	[631]	[861,435,1155,488]	-2	hSpCas9	negative selection	8099587
57141500	57141523	12	-	27260156	PATU8902	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.204080581702766	[783]	[1068,743,804,1234]	-2	hSpCas9	negative selection	8099588
57138522	57138545	12	+	27260156	PATU8902	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.5827144782560091	[471]	[1050,1035,673,1284]	6	hSpCas9	negative selection	8099589
57141402	57141425	12	+	27260156	PATU8902	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.2744968704677022	[1029]	[1714,1966,1597,1675]	2	hSpCas9	negative selection	8163846
57143716	57143739	12	-	27260156	PATU8902	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.7285206792283745	[361]	[979,733,434,1348]	7	hSpCas9	negative selection	8163847
57143717	57143740	12	+	27260156	PATU8902	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.36048409355738675	[572]	[589,986,1400,1018]	3	hSpCas9	negative selection	8163848
57138547	57138570	12	+	27260156	PANC1	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	0.045382770086058954	[631]	[642,561,714,346]	0	hSpCas9	negative selection	8220838
57141500	57141523	12	-	27260156	PANC1	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	0.15390943300129867	[783]	[658,919,951,528]	2	hSpCas9	negative selection	8220839
57138522	57138545	12	+	27260156	PANC1	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.2758615087963545	[471]	[564,505,494,404]	4	hSpCas9	negative selection	8220840
57141402	57141425	12	+	27260156	PANC1	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.16360309368415904	[1029]	[980,1159,1035,831]	2	hSpCas9	negative selection	8285097
57143716	57143739	12	-	27260156	PANC1	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.4668814542143543	[361]	[429,473,383,431]	7	hSpCas9	negative selection	8285098
57143717	57143740	12	+	27260156	PANC1	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.22411225154317294	[572]	[626,653,739,326]	3	hSpCas9	negative selection	8285099
57138547	57138570	12	+	27260156	PANC0813	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.27131989168193954	[631]	[654,464,784,561]	-4	hSpCas9	negative selection	8342089
57141500	57141523	12	-	27260156	PANC0813	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.012453577453795828	[783]	[1129,842,955,750]	0	hSpCas9	negative selection	8342090
57138522	57138545	12	+	27260156	PANC0813	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.49507568092199544	[471]	[1155,726,739,548]	7	hSpCas9	negative selection	8342091
57141402	57141425	12	+	27260156	PANC0813	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.13928716176349054	[1029]	[1284,1396,1543,1110]	2	hSpCas9	negative selection	8406348
57143716	57143739	12	-	27260156	PANC0813	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.2853125485351887	[361]	[507,735,515,321]	4	hSpCas9	negative selection	8406349
57143717	57143740	12	+	27260156	PANC0813	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.36194205426994785	[572]	[493,524,678,400]	-5	hSpCas9	negative selection	8406350
57138547	57138570	12	+	27260156	RDES	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.738207563396482	[631]	[453,339,379,578]	-8	hSpCas9	negative selection	8463340
57141500	57141523	12	-	27260156	RDES	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.6290061342237221	[783]	[478,634,701,507]	-8	hSpCas9	negative selection	8463341
57138522	57138545	12	+	27260156	RDES	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.2009847100862202	[471]	[615,505,714,659]	3	hSpCas9	negative selection	8463342
57141402	57141425	12	+	27260156	RDES	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.18429586267608	[1029]	[1134,960,1517,1904]	3	hSpCas9	negative selection	8527599
57143716	57143739	12	-	27260156	RDES	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.273311535331473	[361]	[285,333,291,488]	-5	hSpCas9	negative selection	8527600
57143717	57143740	12	+	27260156	RDES	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.05973887360819127	[572]	[490,589,697,792]	-1	hSpCas9	negative selection	8527601
57138547	57138570	12	+	27260156	PC3	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	0.1020425995367154	[631]	[461,567,1043,808]	2	hSpCas9	negative selection	8584591
57141500	57141523	12	-	27260156	PC3	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	0.1912933100424642	[783]	[391,786,1756,1143]	4	hSpCas9	negative selection	8584592
57138522	57138545	12	+	27260156	PC3	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.2242156658512064	[471]	[367,378,1082,612]	5	hSpCas9	negative selection	8584593
57141402	57141425	12	+	27260156	PC3	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	-0.0009177803129336581	[1029]	[653,897,1769,1146]	0	hSpCas9	negative selection	8648850
57143716	57143739	12	-	27260156	PC3	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.3488710993872541	[361]	[387,284,797,483]	7	hSpCas9	negative selection	8648851
57143717	57143740	12	+	27260156	PC3	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.05011163839837743	[572]	[274,501,963,713]	-1	hSpCas9	negative selection	8648852
57138547	57138570	12	+	27260156	PATU8988T	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.29398964646001746	[631]	[388,549,513,547]	-5	hSpCas9	negative selection	8705842
57141500	57141523	12	-	27260156	PATU8988T	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.2107828382776732	[783]	[479,619,673,856]	-4	hSpCas9	negative selection	8705843
57138522	57138545	12	+	27260156	PATU8988T	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.9974540676412789	[471]	[1026,967,859,782]	9	hSpCas9	negative selection	8705844
57141402	57141425	12	+	27260156	PATU8988T	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.025254842740586536	[1029]	[1243,1288,720,810]	0	hSpCas9	negative selection	8770101
57143716	57143739	12	-	27260156	PATU8988T	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.06699811561315205	[361]	[283,336,304,416]	-1	hSpCas9	negative selection	8770102
57143717	57143740	12	+	27260156	PATU8988T	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.03896657625313896	[572]	[347,585,518,721]	0	hSpCas9	negative selection	8770103
57138547	57138570	12	+	27260156	T47D	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.32239062935590757	[631]	[575,542,590,650]	-6	hSpCas9	negative selection	8827093
57141500	57141523	12	-	27260156	T47D	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	0.017975623518503125	[783]	[996,791,947,974]	0	hSpCas9	negative selection	8827094
57138522	57138545	12	+	27260156	T47D	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.3898118487790079	[471]	[746,683,766,684]	8	hSpCas9	negative selection	8827095
57141402	57141425	12	+	27260156	T47D	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.20039553040050984	[1029]	[1424,1329,1401,1360]	4	hSpCas9	negative selection	8891352
57143716	57143739	12	-	27260156	T47D	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.12235589579189299	[361]	[443,493,421,473]	2	hSpCas9	negative selection	8891353
57143717	57143740	12	+	27260156	T47D	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.1149910499537474	[572]	[510,723,537,685]	-3	hSpCas9	negative selection	8891354
57138547	57138570	12	+	27260156	SU8686	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.3067946511343368	[631]	[536,503,353,641]	-5	hSpCas9	negative selection	8948344
57141500	57141523	12	-	27260156	SU8686	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.1977492164506598	[783]	[589,596,702,867]	-3	hSpCas9	negative selection	8948345
57138522	57138545	12	+	27260156	SU8686	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.38209818282742736	[471]	[514,429,648,927]	6	hSpCas9	negative selection	8948346
57141402	57141425	12	+	27260156	SU8686	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.011545115839930009	[1029]	[926,813,1212,1233]	0	hSpCas9	negative selection	9012603
57143716	57143739	12	-	27260156	SU8686	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	0.08504374129847203	[361]	[310,337,444,452]	1	hSpCas9	negative selection	9012604
57143717	57143740	12	+	27260156	SU8686	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.001214249986052407	[572]	[632,560,548,505]	0	hSpCas9	negative selection	9012605
57138547	57138570	12	+	27260156	SKES1	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.4822241557045883	[631]	[540,519,486,291]	-8	hSpCas9	negative selection	9069595
57141500	57141523	12	-	27260156	SKES1	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.11898755769033986	[783]	[822,719,786,573]	-3	hSpCas9	negative selection	9069596
57138522	57138545	12	+	27260156	SKES1	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.1068285677553174	[471]	[537,575,430,492]	2	hSpCas9	negative selection	9069597
57141402	57141425	12	+	27260156	SKES1	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.1378277866186739	[1029]	[1387,1232,933,1018]	3	hSpCas9	negative selection	9133854
57143716	57143739	12	-	27260156	SKES1	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.17006998737539125	[361]	[393,283,302,306]	-4	hSpCas9	negative selection	9133855
57143717	57143740	12	+	27260156	SKES1	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.1592486582894822	[572]	[647,635,774,502]	3	hSpCas9	negative selection	9133856
57138547	57138570	12	+	27260156	TOV112D	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.014244295214179692	[631]	[751,772,489,539]	0	hSpCas9	negative selection	9190846
57141500	57141523	12	-	27260156	TOV112D	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.007235445790554906	[783]	[1051,682,661,726]	0	hSpCas9	negative selection	9190847
57138522	57138545	12	+	27260156	TOV112D	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.41659756988223207	[471]	[587,820,668,491]	7	hSpCas9	negative selection	9190848
57141402	57141425	12	+	27260156	TOV112D	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	-0.04346868469385479	[1029]	[891,1477,939,805]	-1	hSpCas9	negative selection	9255105
57143716	57143739	12	-	27260156	TOV112D	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.1434418785433651	[361]	[450,322,273,274]	-3	hSpCas9	negative selection	9255106
57143717	57143740	12	+	27260156	TOV112D	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	0.22762952540165082	[572]	[698,862,499,673]	4	hSpCas9	negative selection	9255107
57138547	57138570	12	+	27260156	TC71	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	-0.07963804013059456	[631]	[664,492,728,675]	-2	hSpCas9	negative selection	9312097
57141500	57141523	12	-	27260156	TC71	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.22480185149887877	[783]	[560,752,772,795]	-6	hSpCas9	negative selection	9312098
57138522	57138545	12	+	27260156	TC71	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.11931821299569403	[471]	[473,616,485,629]	3	hSpCas9	negative selection	9312099
57141402	57141425	12	+	27260156	TC71	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.009116687714582739	[1029]	[1160,1047,1060,1178]	0	hSpCas9	negative selection	9376356
57143716	57143739	12	-	27260156	TC71	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.0767659194751587	[361]	[300,396,325,455]	-2	hSpCas9	negative selection	9376357
57143717	57143740	12	+	27260156	TC71	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.15687223077112353	[572]	[571,553,556,517]	-4	hSpCas9	negative selection	9376358
57138547	57138570	12	+	27260156	TC32	viability	CTGCCCAGACGGATCTGACGAGG	LRP1	ENSG00000123384	0.018626722176814547	[631]	[758,373,690,628]	0	hSpCas9	negative selection	9433348
57141500	57141523	12	-	27260156	TC32	viability	AAAGTCCTTACCTCGGCAGTGGG	LRP1	ENSG00000123384	-0.10691708940807176	[783]	[659,412,802,963]	-2	hSpCas9	negative selection	9433349
57138522	57138545	12	+	27260156	TC32	viability	GCTGGCGGTGCGACGGTGAGAGG	LRP1	ENSG00000123384	0.18632288975412475	[471]	[505,453,581,474]	3	hSpCas9	negative selection	9433350
57141402	57141425	12	+	27260156	TC32	viability	GCCAAACGAGCATAACTGCCTGG	LRP1	ENSG00000123384	0.1499378023405884	[1029]	[1129,708,1508,1091]	2	hSpCas9	negative selection	9497607
57143716	57143739	12	-	27260156	TC32	viability	CATCGAGTGTGGGGACACAATGG	LRP1	ENSG00000123384	-0.38906994700408903	[361]	[310,131,313,321]	-6	hSpCas9	negative selection	9497608
57143717	57143740	12	+	27260156	TC32	viability	CATTGTGTCCCCACACTCGATGG	LRP1	ENSG00000123384	-0.18150116913702127	[572]	[428,238,705,644]	-3	hSpCas9	negative selection	9497609
57128996	57129019	12	-	27869803	HPAFII	viability after 27 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.5071785650430614	[742]	[738,401,NaN]	4	hSpCas9	negative selection	9547864
57138504	57138527	12	+	27869803	HPAFII	viability after 27 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-1.1506571199545437	[123]	[12,42,NaN]	-7	hSpCas9	negative selection	9547865
57141442	57141465	12	+	27869803	HPAFII	viability after 27 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	-0.7584435741273274	[171]	[89,22,NaN]	-5	hSpCas9	negative selection	9547866
57143683	57143706	12	+	27869803	HPAFII	viability after 27 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	-0.9917184450012171	[206]	[27,76,NaN]	-6	hSpCas9	negative selection	9547867
57149703	57149726	12	+	27869803	HPAFII	viability after 27 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-0.37472176812436936	[301]	[110,131,NaN]	-3	hSpCas9	negative selection	9547868
57128996	57129019	12	-	27869803	HPAFII	viability after 15 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.30268112850699325	[742]	[1447,696,NaN]	3	hSpCas9	negative selection	9630313
57138504	57138527	12	+	27869803	HPAFII	viability after 15 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-0.36229675886027324	[123]	[152,72,NaN]	-4	hSpCas9	negative selection	9630314
57141442	57141465	12	+	27869803	HPAFII	viability after 15 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	0.25708672438783803	[171]	[342,144,NaN]	3	hSpCas9	negative selection	9630315
57143683	57143706	12	+	27869803	HPAFII	viability after 15 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	-0.5984132595432428	[206]	[178,126,NaN]	-6	hSpCas9	negative selection	9630316
57149703	57149726	12	+	27869803	HPAFII	viability after 15 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	0.2887401742627729	[301]	[578,282,NaN]	3	hSpCas9	negative selection	9630317
57128996	57129019	12	-	27869803	ASPC1	viability after 36 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.9004617119352258	[1717]	[1376,733,1232]	8	hSpCas9	negative selection	9712762
57138504	57138527	12	+	27869803	ASPC1	viability after 36 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-1.2336552517559003	[365]	[55,78,32]	-8	hSpCas9	negative selection	9712763
57141442	57141465	12	+	27869803	ASPC1	viability after 36 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	-0.7268784313816055	[544]	[95,148,99]	-6	hSpCas9	negative selection	9712764
57143683	57143706	12	+	27869803	ASPC1	viability after 36 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	0.4752163275612529	[400]	[127,466,22]	5	hSpCas9	negative selection	9712765
57149703	57149726	12	+	27869803	ASPC1	viability after 36 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	0.43907391874028073	[796]	[593,205,356]	4	hSpCas9	negative selection	9712766
57128996	57129019	12	-	27869803	PATU8988S	viability after 35 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	1.051466414085375	[1213]	[1184,840,NaN]	9	hSpCas9	negative selection	9795211
57138504	57138527	12	+	27869803	PATU8988S	viability after 35 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-0.35917946589781136	[306]	[49,142,NaN]	-4	hSpCas9	negative selection	9795212
57141442	57141465	12	+	27869803	PATU8988S	viability after 35 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	1.593741565414671	[516]	[618,637,NaN]	9	hSpCas9	negative selection	9795213
57143683	57143706	12	+	27869803	PATU8988S	viability after 35 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	-0.29635984165279616	[359]	[146,88,NaN]	-3	hSpCas9	negative selection	9795214
57149703	57149726	12	+	27869803	PATU8988S	viability after 35 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-1.028861645470764	[667]	[67,195,NaN]	-7	hSpCas9	negative selection	9795215
57128996	57129019	12	-	27869803	PATU8988S	viability after 31 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.7265810859128079	[1213]	[822,772,NaN]	8	hSpCas9	negative selection	9877660
57138504	57138527	12	+	27869803	PATU8988S	viability after 31 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-0.19860072198304146	[306]	[63,160,NaN]	-2	hSpCas9	negative selection	9877661
57141442	57141465	12	+	27869803	PATU8988S	viability after 31 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	1.2970427879103885	[516]	[323,738,NaN]	9	hSpCas9	negative selection	9877662
57143683	57143706	12	+	27869803	PATU8988S	viability after 31 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	-0.6243639412528644	[359]	[93,91,NaN]	-6	hSpCas9	negative selection	9877663
57149703	57149726	12	+	27869803	PATU8988S	viability after 31 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-0.11544089046732842	[667]	[233,260,NaN]	-1	hSpCas9	negative selection	9877664
57128996	57129019	12	-	27869803	HPAFII	viability after 35 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.4369856379787116	[742]	[575,433,NaN]	3	hSpCas9	negative selection	9960109
57138504	57138527	12	+	27869803	HPAFII	viability after 35 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-0.3734299735063662	[123]	[23,75,NaN]	-2	hSpCas9	negative selection	9960110
57141442	57141465	12	+	27869803	HPAFII	viability after 35 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	-1.4121032431694422	[171]	[59,1,NaN]	-6	hSpCas9	negative selection	9960111
57143683	57143706	12	+	27869803	HPAFII	viability after 35 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	-2.0512122112714115	[206]	[5,46,NaN]	-8	hSpCas9	negative selection	9960112
57149703	57149726	12	+	27869803	HPAFII	viability after 35 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-0.4742827158345695	[301]	[94,126,NaN]	-3	hSpCas9	negative selection	9960113
57128996	57129019	12	-	27869803	HPAFII	viability after 31 days	CGCGACCAGAGCTGAGAGCAGGG	LRP1	ENSG00000123384	0.26455217325845637	[742]	[509,490,NaN]	2	hSpCas9	negative selection	10042558
57138504	57138527	12	+	27869803	HPAFII	viability after 31 days	TAACCTGTATCTCAAAGGGCTGG	LRP1	ENSG00000123384	-0.8417783868891924	[123]	[34,42,NaN]	-5	hSpCas9	negative selection	10042559
57141442	57141465	12	+	27869803	HPAFII	viability after 31 days	CCCATGTCCCGCCTCTGCAATGG	LRP1	ENSG00000123384	-1.1762468028863393	[171]	[80,0,NaN]	-6	hSpCas9	negative selection	10042560
57143683	57143706	12	+	27869803	HPAFII	viability after 31 days	CCAAGGCAACTGCTCTCGCCTGG	LRP1	ENSG00000123384	-1.7429550576517487	[206]	[16,53,NaN]	-7	hSpCas9	negative selection	10042561
57149703	57149726	12	+	27869803	HPAFII	viability after 31 days	GAGAACGAGGTGACACAACACGG	LRP1	ENSG00000123384	-0.6862805149629756	[301]	[67,145,NaN]	-4	hSpCas9	negative selection	10042562
57129000	57129023	12	+	28162770	P31FUJ	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	0.24112898391803372	[89]	[124]	2	hSpCas9	negative selection	10185770
57143777	57143800	12	+	28162770	P31FUJ	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	-0.5608564020985823	[117]	[93]	-5	hSpCas9	negative selection	10185771
57176064	57176087	12	+	28162770	P31FUJ	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	0.15480206474135294	[291]	[381]	1	hSpCas9	negative selection	10185772
57178518	57178541	12	+	28162770	P31FUJ	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	0.37488037280686126	[398]	[607]	4	hSpCas9	negative selection	10185773
57184898	57184921	12	+	28162770	P31FUJ	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	-0.1012053216311658	[177]	[194]	-1	hSpCas9	negative selection	10185774
57197114	57197137	12	+	28162770	P31FUJ	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	-1.5028913677821227	[163]	[67]	-7	hSpCas9	negative selection	10185775
57211772	57211795	12	-	28162770	P31FUJ	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	0.02407340854063955	[625]	[747]	0	hSpCas9	negative selection	10185776
57128972	57128995	12	-	28162770	P31FUJ	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	0.230765188792124	[284]	[392]	2	hSpCas9	negative selection	10185777
57141490	57141513	12	+	28162770	P31FUJ	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	0.15596964017065962	[96]	[126]	1	hSpCas9	negative selection	10185778
57143742	57143765	12	-	28162770	P31FUJ	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	0.03520334356968424	[337]	[406]	0	hSpCas9	negative selection	10185779
57129000	57129023	12	+	28162770	TF1	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	NaN	[NaN]	[14]	1	hSpCas9	negative selection	10355136
57143777	57143800	12	+	28162770	TF1	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	NaN	[NaN]	[89]	1	hSpCas9	negative selection	10355137
57176064	57176087	12	+	28162770	TF1	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	NaN	[NaN]	[156]	1	hSpCas9	negative selection	10355138
57178518	57178541	12	+	28162770	TF1	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	NaN	[NaN]	[359]	1	hSpCas9	negative selection	10355139
57184898	57184921	12	+	28162770	TF1	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	NaN	[NaN]	[198]	1	hSpCas9	negative selection	10355140
57197114	57197137	12	+	28162770	TF1	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	NaN	[NaN]	[147]	1	hSpCas9	negative selection	10355141
57211772	57211795	12	-	28162770	TF1	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	NaN	[NaN]	[473]	1	hSpCas9	negative selection	10355142
57128972	57128995	12	-	28162770	TF1	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	NaN	[NaN]	[145]	1	hSpCas9	negative selection	10355143
57141490	57141513	12	+	28162770	TF1	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	NaN	[NaN]	[16]	1	hSpCas9	negative selection	10355144
57143742	57143765	12	-	28162770	TF1	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	NaN	[NaN]	[233]	1	hSpCas9	negative selection	10355145
57129000	57129023	12	+	28162770	SKM1	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	0.22380199159111935	[30]	[63]	2	hSpCas9	negative selection	10524502
57143777	57143800	12	+	28162770	SKM1	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	-1.2370391973008492	[15]	[11]	-7	hSpCas9	negative selection	10524503
57176064	57176087	12	+	28162770	SKM1	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	0.7368715738304897	[92]	[273]	7	hSpCas9	negative selection	10524504
57178518	57178541	12	+	28162770	SKM1	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	0.40039072331444214	[122]	[286]	4	hSpCas9	negative selection	10524505
57184898	57184921	12	+	28162770	SKM1	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	-0.0009718390673248006	[59]	[105]	0	hSpCas9	negative selection	10524506
57197114	57197137	12	+	28162770	SKM1	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	-0.28358178323787964	[41]	[60]	-2	hSpCas9	negative selection	10524507
57211772	57211795	12	-	28162770	SKM1	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	0.07456871232258888	[158]	[295]	0	hSpCas9	negative selection	10524508
57128972	57128995	12	-	28162770	SKM1	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	1.0948043664515956	[57]	[218]	8	hSpCas9	negative selection	10524509
57141490	57141513	12	+	28162770	SKM1	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	-0.9215373715729199	[29]	[27]	-6	hSpCas9	negative selection	10524510
57143742	57143765	12	-	28162770	SKM1	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	-0.08864735740817825	[79]	[132]	0	hSpCas9	negative selection	10524511
57129000	57129023	12	+	28162770	SKM1	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	0.22380199159111935	[30]	[63]	2	hSpCas9	negative selection	10693868
57143777	57143800	12	+	28162770	SKM1	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	-1.2370391973008492	[15]	[11]	-7	hSpCas9	negative selection	10693869
57176064	57176087	12	+	28162770	SKM1	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	0.7368715738304897	[92]	[273]	7	hSpCas9	negative selection	10693870
57178518	57178541	12	+	28162770	SKM1	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	0.40039072331444214	[122]	[286]	4	hSpCas9	negative selection	10693871
57184898	57184921	12	+	28162770	SKM1	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	-0.0009718390673248006	[59]	[105]	0	hSpCas9	negative selection	10693872
57197114	57197137	12	+	28162770	SKM1	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	-0.28358178323787964	[41]	[60]	-2	hSpCas9	negative selection	10693873
57211772	57211795	12	-	28162770	SKM1	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	0.07456871232258888	[158]	[295]	0	hSpCas9	negative selection	10693874
57128972	57128995	12	-	28162770	SKM1	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	1.0948043664515956	[57]	[218]	8	hSpCas9	negative selection	10693875
57141490	57141513	12	+	28162770	SKM1	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	-0.9215373715729199	[29]	[27]	-6	hSpCas9	negative selection	10693876
57143742	57143765	12	-	28162770	SKM1	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	-0.08864735740817825	[79]	[132]	0	hSpCas9	negative selection	10693877
57129000	57129023	12	+	28162770	PL21	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	-0.08163135392605958	[123]	[50]	0	hSpCas9	negative selection	10863234
57143777	57143800	12	+	28162770	PL21	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	-3.00931375113963	[73]	[3]	-9	hSpCas9	negative selection	10863235
57176064	57176087	12	+	28162770	PL21	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	0.4282989790446545	[320]	[187]	4	hSpCas9	negative selection	10863236
57178518	57178541	12	+	28162770	PL21	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	0.5871627375985673	[389]	[254]	5	hSpCas9	negative selection	10863237
57184898	57184921	12	+	28162770	PL21	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	-0.6692762757005354	[189]	[51]	-5	hSpCas9	negative selection	10863238
57197114	57197137	12	+	28162770	PL21	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	-0.476163197770262	[162]	[50]	-3	hSpCas9	negative selection	10863239
57211772	57211795	12	-	28162770	PL21	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	-0.08791705781890635	[441]	[180]	0	hSpCas9	negative selection	10863240
57128972	57128995	12	-	28162770	PL21	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	0.08108694284555694	[201]	[92]	0	hSpCas9	negative selection	10863241
57141490	57141513	12	+	28162770	PL21	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	0.3403172725375805	[97]	[53]	3	hSpCas9	negative selection	10863242
57143742	57143765	12	-	28162770	PL21	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	-1.0201903403902355	[232]	[49]	-6	hSpCas9	negative selection	10863243
57129000	57129023	12	+	28162770	P31FUJ	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	0.24112898391803372	[89]	[124]	2	hSpCas9	negative selection	11032600
57143777	57143800	12	+	28162770	P31FUJ	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	-0.5608564020985823	[117]	[93]	-5	hSpCas9	negative selection	11032601
57176064	57176087	12	+	28162770	P31FUJ	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	0.15480206474135294	[291]	[381]	1	hSpCas9	negative selection	11032602
57178518	57178541	12	+	28162770	P31FUJ	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	0.37488037280686126	[398]	[607]	4	hSpCas9	negative selection	11032603
57184898	57184921	12	+	28162770	P31FUJ	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	-0.1012053216311658	[177]	[194]	-1	hSpCas9	negative selection	11032604
57197114	57197137	12	+	28162770	P31FUJ	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	-1.5028913677821227	[163]	[67]	-7	hSpCas9	negative selection	11032605
57211772	57211795	12	-	28162770	P31FUJ	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	0.02407340854063955	[625]	[747]	0	hSpCas9	negative selection	11032606
57128972	57128995	12	-	28162770	P31FUJ	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	0.230765188792124	[284]	[392]	2	hSpCas9	negative selection	11032607
57141490	57141513	12	+	28162770	P31FUJ	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	0.15596964017065962	[96]	[126]	1	hSpCas9	negative selection	11032608
57143742	57143765	12	-	28162770	P31FUJ	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	0.03520334356968424	[337]	[406]	0	hSpCas9	negative selection	11032609
57129000	57129023	12	+	28162770	OCIAML5	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	0.19855950220597074	[27]	[57]	1	hSpCas9	negative selection	11201966
57143777	57143800	12	+	28162770	OCIAML5	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	0.12907440188468705	[76]	[151]	1	hSpCas9	negative selection	11201967
57176064	57176087	12	+	28162770	OCIAML5	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	-0.14390500534516876	[171]	[280]	-1	hSpCas9	negative selection	11201968
57178518	57178541	12	+	28162770	OCIAML5	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	0.4955481676870148	[166]	[424]	4	hSpCas9	negative selection	11201969
57184898	57184921	12	+	28162770	OCIAML5	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	0.2519564936792313	[106]	[229]	2	hSpCas9	negative selection	11201970
57197114	57197137	12	+	28162770	OCIAML5	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	0.8529266335639292	[72]	[237]	7	hSpCas9	negative selection	11201971
57211772	57211795	12	-	28162770	OCIAML5	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	0.2477973236053821	[292]	[627]	2	hSpCas9	negative selection	11201972
57128972	57128995	12	-	28162770	OCIAML5	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	-0.14919875390421897	[136]	[222]	-1	hSpCas9	negative selection	11201973
57141490	57141513	12	+	28162770	OCIAML5	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	0.230395589327976	[50]	[107]	2	hSpCas9	negative selection	11201974
57143742	57143765	12	-	28162770	OCIAML5	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	-0.01979401660206348	[204]	[364]	0	hSpCas9	negative selection	11201975
57129000	57129023	12	+	28162770	EOL1	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	0.7546227701282222	[161]	[143]	6	hSpCas9	negative selection	11371332
57143777	57143800	12	+	28162770	EOL1	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	0.3530057866117	[106]	[71]	3	hSpCas9	negative selection	11371333
57176064	57176087	12	+	28162770	EOL1	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	1.1843541545500993	[521]	[624]	8	hSpCas9	negative selection	11371334
57178518	57178541	12	+	28162770	EOL1	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	0.5032512818200086	[769]	[574]	4	hSpCas9	negative selection	11371335
57184898	57184921	12	+	28162770	EOL1	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	0.49076654995099334	[438]	[324]	4	hSpCas9	negative selection	11371336
57197114	57197137	12	+	28162770	EOL1	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	-0.7770596480028921	[308]	[94]	-5	hSpCas9	negative selection	11371337
57211772	57211795	12	-	28162770	EOL1	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	0.5644699321334234	[660]	[514]	5	hSpCas9	negative selection	11371338
57128972	57128995	12	-	28162770	EOL1	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	-0.7956745587610952	[256]	[77]	-5	hSpCas9	negative selection	11371339
57141490	57141513	12	+	28162770	EOL1	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	-0.2849055940584153	[110]	[47]	-2	hSpCas9	negative selection	11371340
57143742	57143765	12	-	28162770	EOL1	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	1.0576565532631141	[268]	[294]	8	hSpCas9	negative selection	11371341
57129000	57129023	12	+	28162770	MOLM13	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	0.7163264111654147	[148]	[176]	5	hSpCas9	negative selection	11540698
57143777	57143800	12	+	28162770	MOLM13	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	-1.5495980451842621	[165]	[40]	-6	hSpCas9	negative selection	11540699
57176064	57176087	12	+	28162770	MOLM13	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	0.8437562835427451	[419]	[544]	6	hSpCas9	negative selection	11540700
57178518	57178541	12	+	28162770	MOLM13	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	0.04055261731529147	[588]	[437]	0	hSpCas9	negative selection	11540701
57184898	57184921	12	+	28162770	MOLM13	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	0.5416377215258913	[285]	[300]	4	hSpCas9	negative selection	11540702
57197114	57197137	12	+	28162770	MOLM13	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	0.8106220915712374	[178]	[226]	6	hSpCas9	negative selection	11540703
57211772	57211795	12	-	28162770	MOLM13	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	0.22492535028662397	[670]	[566]	1	hSpCas9	negative selection	11540704
57128972	57128995	12	-	28162770	MOLM13	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	-0.3809690926925246	[334]	[185]	-2	hSpCas9	negative selection	11540705
57141490	57141513	12	+	28162770	MOLM13	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	1.480489418324212	[113]	[229]	9	hSpCas9	negative selection	11540706
57143742	57143765	12	-	28162770	MOLM13	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	-1.2618446433905515	[198]	[59]	-6	hSpCas9	negative selection	11540707
57129000	57129023	12	+	28162770	HEL	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	-0.24360438620407587	[121]	[65]	-2	hSpCas9	negative selection	11710064
57143777	57143800	12	+	28162770	HEL	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	0.264227208746627	[103]	[79]	2	hSpCas9	negative selection	11710065
57176064	57176087	12	+	28162770	HEL	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	0.1735146463454723	[424]	[306]	1	hSpCas9	negative selection	11710066
57178518	57178541	12	+	28162770	HEL	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	0.4328916639830226	[457]	[395]	3	hSpCas9	negative selection	11710067
57184898	57184921	12	+	28162770	HEL	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	0.3646822355489102	[250]	[206]	3	hSpCas9	negative selection	11710068
57197114	57197137	12	+	28162770	HEL	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	-0.028638420538272313	[171]	[107]	0	hSpCas9	negative selection	11710069
57211772	57211795	12	-	28162770	HEL	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	-0.4777948333071316	[523]	[240]	-3	hSpCas9	negative selection	11710070
57128972	57128995	12	-	28162770	HEL	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	0.6320124254072984	[269]	[267]	5	hSpCas9	negative selection	11710071
57141490	57141513	12	+	28162770	HEL	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	-0.49476469174957804	[98]	[44]	-3	hSpCas9	negative selection	11710072
57143742	57143765	12	-	28162770	HEL	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	-0.6936888325821203	[249]	[98]	-4	hSpCas9	negative selection	11710073
57129000	57129023	12	+	28162770	MV411	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	0.20436882889088925	[101]	[98]	1	hSpCas9	negative selection	11879430
57143777	57143800	12	+	28162770	MV411	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	0.6917396445668141	[60]	[82]	6	hSpCas9	negative selection	11879431
57176064	57176087	12	+	28162770	MV411	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	0.5180187656699172	[285]	[344]	4	hSpCas9	negative selection	11879432
57178518	57178541	12	+	28162770	MV411	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	0.5586392390770791	[377]	[468]	5	hSpCas9	negative selection	11879433
57184898	57184921	12	+	28162770	MV411	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	-0.32695570822819353	[203]	[136]	-2	hSpCas9	negative selection	11879434
57197114	57197137	12	+	28162770	MV411	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	0.36818971024338554	[125]	[136]	3	hSpCas9	negative selection	11879435
57211772	57211795	12	-	28162770	MV411	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	0.48243441225270844	[406]	[478]	4	hSpCas9	negative selection	11879436
57128972	57128995	12	-	28162770	MV411	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	0.40880053872166355	[168]	[188]	3	hSpCas9	negative selection	11879437
57141490	57141513	12	+	28162770	MV411	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	0.8649679139603621	[72]	[111]	7	hSpCas9	negative selection	11879438
57143742	57143765	12	-	28162770	MV411	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	0.7913241085010159	[189]	[276]	7	hSpCas9	negative selection	11879439
57129000	57129023	12	+	28162770	MONOMAC1	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	0.28213098963900585	[65]	[91]	3	hSpCas9	negative selection	12048796
57143777	57143800	12	+	28162770	MONOMAC1	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	0.5399287471066524	[50]	[84]	5	hSpCas9	negative selection	12048797
57176064	57176087	12	+	28162770	MONOMAC1	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	0.565129301231795	[226]	[384]	5	hSpCas9	negative selection	12048798
57178518	57178541	12	+	28162770	MONOMAC1	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	-0.7463754380499886	[239]	[163]	-6	hSpCas9	negative selection	12048799
57184898	57184921	12	+	28162770	MONOMAC1	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	-0.5432124881935934	[149]	[117]	-4	hSpCas9	negative selection	12048800
57197114	57197137	12	+	28162770	MONOMAC1	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	0.11524107779408951	[119]	[148]	1	hSpCas9	negative selection	12048801
57211772	57211795	12	-	28162770	MONOMAC1	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	-0.12443309810271375	[309]	[325]	-1	hSpCas9	negative selection	12048802
57128972	57128995	12	-	28162770	MONOMAC1	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	-0.9450576297347555	[130]	[77]	-6	hSpCas9	negative selection	12048803
57141490	57141513	12	+	28162770	MONOMAC1	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	-0.06273575534796239	[40]	[44]	0	hSpCas9	negative selection	12048804
57143742	57143765	12	-	28162770	MONOMAC1	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	-0.6923621352960335	[116]	[82]	-5	hSpCas9	negative selection	12048805
57129000	57129023	12	+	28162770	OCIAML2	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	-0.23616457160513837	[16]	[79]	-2	hSpCas9	negative selection	12218162
57143777	57143800	12	+	28162770	OCIAML2	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	1.9353625344336756	[4]	[105]	9	hSpCas9	negative selection	12218163
57176064	57176087	12	+	28162770	OCIAML2	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	0.38070279387604533	[59]	[432]	3	hSpCas9	negative selection	12218164
57178518	57178541	12	+	28162770	OCIAML2	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	0.608197791180166	[68]	[582]	6	hSpCas9	negative selection	12218165
57184898	57184921	12	+	28162770	OCIAML2	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	0.49284429873272484	[39]	[311]	5	hSpCas9	negative selection	12218166
57197114	57197137	12	+	28162770	OCIAML2	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	-0.6377398110774195	[31]	[113]	-5	hSpCas9	negative selection	12218167
57211772	57211795	12	-	28162770	OCIAML2	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	-0.3178595448389159	[93]	[417]	-3	hSpCas9	negative selection	12218168
57128972	57128995	12	-	28162770	OCIAML2	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	-0.13020538673740936	[30]	[156]	-1	hSpCas9	negative selection	12218169
57141490	57141513	12	+	28162770	OCIAML2	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	0.276604104377872	[13]	[93]	2	hSpCas9	negative selection	12218170
57143742	57143765	12	-	28162770	OCIAML2	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	-0.019968416232595987	[29]	[163]	0	hSpCas9	negative selection	12218171
57129000	57129023	12	+	28162770	OCIAML3	viability	GCTCTCAGCTCTGGTCGCGGCGG	LRP1	ENSG00000123384	0.25101769969949583	[26]	[96]	2	hSpCas9	negative selection	12387528
57143777	57143800	12	+	28162770	OCIAML3	viability	GCAGATGGCAAGACCTGCAAAGG	LRP1	ENSG00000123384	1.8028825122444214	[14]	[157]	9	hSpCas9	negative selection	12387529
57176064	57176087	12	+	28162770	OCIAML3	viability	GTGGAGGACAAGATCTACCGCGG	LRP1	ENSG00000123384	-0.44426052081948103	[95]	[212]	-3	hSpCas9	negative selection	12387530
57178518	57178541	12	+	28162770	OCIAML3	viability	GACCGGCCACAATGTCACCGTGG	LRP1	ENSG00000123384	0.010854417834697871	[95]	[291]	0	hSpCas9	negative selection	12387531
57184898	57184921	12	+	28162770	OCIAML3	viability	GACAGGTGAGAACCGCGAGGTGG	LRP1	ENSG00000123384	0.16555938277917565	[56]	[192]	1	hSpCas9	negative selection	12387532
57197114	57197137	12	+	28162770	OCIAML3	viability	GAGGGCTATGCACCCCGCGGCGG	LRP1	ENSG00000123384	0.26658930301042055	[37]	[137]	2	hSpCas9	negative selection	12387533
57211772	57211795	12	-	28162770	OCIAML3	viability	AAGACGTGCTCCTCACACCGGGG	LRP1	ENSG00000123384	0.2460134706537629	[130]	[468]	2	hSpCas9	negative selection	12387534
57128972	57128995	12	-	28162770	OCIAML3	viability	CAGCAGCAGGAGCAACGGCGGGG	LRP1	ENSG00000123384	0.3832722831757531	[47]	[188]	3	hSpCas9	negative selection	12387535
57141490	57141513	12	+	28162770	OCIAML3	viability	GATGAGGGGCCCCACTGCCGAGG	LRP1	ENSG00000123384	-0.1651643415202888	[25]	[69]	-1	hSpCas9	negative selection	12387536
57143742	57143765	12	-	28162770	OCIAML3	viability	GCTGCTGTTGCAGTAGCAGGTGG	LRP1	ENSG00000123384	0.5089106726214034	[70]	[304]	5	hSpCas9	negative selection	12387537