Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:53353
• Symbol:LRP1B
• Description:LDL receptor related protein 1B

DataSource: http://genomecrispr.dkfz.de/#!/results/LRP1B

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
140886158	140886181	2	-	26472758	Jiyoye	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	-0.7024491096686246	[122]	[56]	-5	hSpCas9	negative selection	92348
140908055	140908078	2	-	26472758	Jiyoye	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	0.24571195881175711	[169]	[151]	1	hSpCas9	negative selection	92349
140867737	140867760	2	+	26472758	Jiyoye	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	1.188535095030533	[31]	[54]	7	hSpCas9	negative selection	92350
140238192	140238215	2	-	26472758	Jiyoye	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	1.7170306440926608	[47]	[118]	8	hSpCas9	negative selection	92351
141188477	141188500	2	+	26472758	Jiyoye	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	6.747025384390498	[0]	[80]	9	hSpCas9	negative selection	92352
141015865	141015888	2	-	26472758	Jiyoye	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	2.371842308393593	[61]	[241]	9	hSpCas9	negative selection	92353
141013697	141013720	2	+	26472758	Jiyoye	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	1.8270786359565332	[36]	[98]	8	hSpCas9	negative selection	92354
141013611	141013634	2	-	26472758	Jiyoye	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	-0.6777135160806396	[139]	[65]	-5	hSpCas9	negative selection	92355
140989593	140989616	2	-	26472758	Jiyoye	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	1.7608123361205739	[44]	[114]	8	hSpCas9	negative selection	92356
140923082	140923105	2	+	26472758	Jiyoye	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	0.059252078085566484	[83]	[65]	0	hSpCas9	negative selection	92357
140886158	140886181	2	-	26472758	KBM7	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	-0.9268700362853315	[451,254]	[87,82]	-6	hSpCas9	negative selection	283466
140908055	140908078	2	-	26472758	KBM7	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	0.007389857183265847	[565,590]	[353,204]	0	hSpCas9	negative selection	283467
140867737	140867760	2	+	26472758	KBM7	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	-0.004473535408654805	[575,289]	[251,147]	0	hSpCas9	negative selection	283468
140238192	140238215	2	-	26472758	KBM7	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	0.926874487859771	[432,433]	[654,151]	8	hSpCas9	negative selection	283469
141188477	141188500	2	+	26472758	KBM7	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	-0.45389285899915366	[265,212]	[115,50]	-4	hSpCas9	negative selection	283470
141015865	141015888	2	-	26472758	KBM7	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	0.4245459660865004	[771,648]	[614,295]	4	hSpCas9	negative selection	283471
141013697	141013720	2	+	26472758	KBM7	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	-0.23514285165419935	[330,231]	[101,118]	-2	hSpCas9	negative selection	283472
141013611	141013634	2	-	26472758	KBM7	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	0.18771690148010678	[306,291]	[136,181]	2	hSpCas9	negative selection	283473
140989593	140989616	2	-	26472758	KBM7	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	0.044635491397108776	[521,460]	[303,178]	0	hSpCas9	negative selection	283474
140923082	140923105	2	+	26472758	KBM7	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	-0.45069362212498904	[352,445]	[153,126]	-4	hSpCas9	negative selection	283475
140886158	140886181	2	-	26472758	Raji	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	-0.5904730217534901	[278]	[42]	-5	hSpCas9	negative selection	474584
140908055	140908078	2	-	26472758	Raji	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	0.6189583800561391	[288]	[102]	6	hSpCas9	negative selection	474585
140867737	140867760	2	+	26472758	Raji	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	-0.2796395877356478	[203]	[38]	-2	hSpCas9	negative selection	474586
140238192	140238215	2	-	26472758	Raji	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	1.0283119643824008	[149]	[70]	8	hSpCas9	negative selection	474587
141188477	141188500	2	+	26472758	Raji	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	-2.4603009739157216	[165]	[6]	-9	hSpCas9	negative selection	474588
141015865	141015888	2	-	26472758	Raji	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	0.20659313930149886	[294]	[78]	2	hSpCas9	negative selection	474589
141013697	141013720	2	+	26472758	Raji	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	0.8479969065549501	[78]	[32]	7	hSpCas9	negative selection	474590
141013611	141013634	2	-	26472758	Raji	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	-0.246253419241101	[137]	[26]	-2	hSpCas9	negative selection	474591
140989593	140989616	2	-	26472758	Raji	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	-0.49017900212719023	[229]	[37]	-4	hSpCas9	negative selection	474592
140923082	140923105	2	+	26472758	Raji	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	-0.36578813989000014	[210]	[37]	-3	hSpCas9	negative selection	474593
140886158	140886181	2	-	26472758	K562	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	-1.4324662624957485	[242]	[75]	-6	hSpCas9	negative selection	665702
140908055	140908078	2	-	26472758	K562	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	1.3060732455802362	[354]	[740]	9	hSpCas9	negative selection	665703
140867737	140867760	2	+	26472758	K562	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	-1.7066716718526067	[463]	[119]	-7	hSpCas9	negative selection	665704
140238192	140238215	2	-	26472758	K562	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	0.26908078190071594	[289]	[294]	2	hSpCas9	negative selection	665705
141188477	141188500	2	+	26472758	K562	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	0.6925145155245862	[150]	[205]	6	hSpCas9	negative selection	665706
141015865	141015888	2	-	26472758	K562	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	-0.35519054901911085	[593]	[391]	-2	hSpCas9	negative selection	665707
141013697	141013720	2	+	26472758	K562	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	-0.8058155748536897	[262]	[126]	-5	hSpCas9	negative selection	665708
141013611	141013634	2	-	26472758	K562	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	0.23766136149113815	[213]	[212]	1	hSpCas9	negative selection	665709
140989593	140989616	2	-	26472758	K562	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	0.1208440425479145	[401]	[368]	0	hSpCas9	negative selection	665710
140923082	140923105	2	+	26472758	K562	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	-0.8457790813051312	[329]	[154]	-5	hSpCas9	negative selection	665711
141055151	141055174	2	-	26627737	DLD1	viability	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	-0.0149112965458289	[972]	[366,295,247]	0	hSpCas9	negative selection	808753
141062198	141062221	2	-	26627737	DLD1	viability	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.22977011383038493	[1136]	[614,423,238]	2	hSpCas9	negative selection	808754
141188509	141188532	2	+	26627737	DLD1	viability	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	0.18564631767817874	[580]	[202,187,224]	2	hSpCas9	negative selection	808756
141480486	141480509	2	+	26627737	DLD1	viability	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	-1.089514227054892	[379]	[61,59,46]	-7	hSpCas9	negative selection	808757
141810362	141810385	2	+	26627737	DLD1	viability	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	1.4629509749243128	[126]	[71,124,128]	9	hSpCas9	negative selection	808758
142130672	142130695	2	-	26627737	DLD1	viability	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-0.8236537390999334	[281]	[76,66,11]	-7	hSpCas9	negative selection	808760
141055151	141055174	2	-	26627737	GBM cells	viability after 5 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.6439845186889468	[283]	[231,243]	8	hSpCas9	negative selection	891068
141062198	141062221	2	-	26627737	GBM cells	viability after 5 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.20109803447463293	[514]	[299,334]	3	hSpCas9	negative selection	891069
141188509	141188532	2	+	26627737	GBM cells	viability after 5 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	-0.4501746778031124	[562]	[244,196]	-6	hSpCas9	negative selection	891071
141480486	141480509	2	+	26627737	GBM cells	viability after 5 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	-0.3729986822945611	[162]	[58,75]	-5	hSpCas9	negative selection	891072
141810362	141810385	2	+	26627737	GBM cells	viability after 5 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.3702195938112748	[131]	[101,80]	5	hSpCas9	negative selection	891073
142130672	142130695	2	-	26627737	GBM cells	viability after 5 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	0.04866099439036753	[127]	[55,85]	0	hSpCas9	negative selection	891075
141055151	141055174	2	-	26627737	GBM cells	viability after 13 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.7918197632657294	[283]	[295,242]	8	hSpCas9	negative selection	973383
141062198	141062221	2	-	26627737	GBM cells	viability after 13 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.588172569728838	[514]	[429,411]	7	hSpCas9	negative selection	973384
141188509	141188532	2	+	26627737	GBM cells	viability after 13 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	-0.760444140443354	[562]	[208,156]	-7	hSpCas9	negative selection	973386
141480486	141480509	2	+	26627737	GBM cells	viability after 13 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	-0.25803203382418505	[162]	[127,29]	-3	hSpCas9	negative selection	973387
141810362	141810385	2	+	26627737	GBM cells	viability after 13 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.1640062977250435	[131]	[82,77]	2	hSpCas9	negative selection	973388
142130672	142130695	2	-	26627737	GBM cells	viability after 13 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	0.2774482390547759	[127]	[92,76]	3	hSpCas9	negative selection	973390
141055151	141055174	2	-	26627737	GBM cells	viability after 21 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.9144247616970743	[283]	[306,275]	8	hSpCas9	negative selection	1055698
141062198	141062221	2	-	26627737	GBM cells	viability after 21 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.6318777387117918	[514]	[443,423]	6	hSpCas9	negative selection	1055699
141188509	141188532	2	+	26627737	GBM cells	viability after 21 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	-0.5297449987245706	[562]	[214,208]	-5	hSpCas9	negative selection	1055701
141480486	141480509	2	+	26627737	GBM cells	viability after 21 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	-0.46649250170427137	[162]	[61,65]	-4	hSpCas9	negative selection	1055702
141810362	141810385	2	+	26627737	GBM cells	viability after 21 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.36079437161408423	[131]	[89,93]	4	hSpCas9	negative selection	1055703
142130672	142130695	2	-	26627737	GBM cells	viability after 21 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	0.9532441935129258	[127]	[142,126]	8	hSpCas9	negative selection	1055705
141055151	141055174	2	-	26627737	RPE1	viability after 9 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	-0.28220339204557	[2571]	[552,802]	-2	hSpCas9	negative selection	1138013
141062198	141062221	2	-	26627737	RPE1	viability after 9 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.3411970746161963	[1791]	[625,819]	2	hSpCas9	negative selection	1138014
141188509	141188532	2	+	26627737	RPE1	viability after 9 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	-0.7659889842471135	[1419]	[191,350]	-5	hSpCas9	negative selection	1138016
141480486	141480509	2	+	26627737	RPE1	viability after 9 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	2.416470341055379	[41]	[74,63]	9	hSpCas9	negative selection	1138017
141810362	141810385	2	+	26627737	RPE1	viability after 9 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.6951415017740034	[248]	[106,150]	4	hSpCas9	negative selection	1138018
142130672	142130695	2	-	26627737	RPE1	viability after 9 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-1.5101071856084585	[1233]	[108,169]	-8	hSpCas9	negative selection	1138020
141055151	141055174	2	-	26627737	RPE1	viability after 12 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	-0.2779623695388074	[2571]	[464,680]	-2	hSpCas9	negative selection	1220328
141062198	141062221	2	-	26627737	RPE1	viability after 12 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.19279355540138887	[1791]	[542,557]	1	hSpCas9	negative selection	1220329
141188509	141188532	2	+	26627737	RPE1	viability after 12 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	-0.5593922556543578	[1419]	[237,280]	-4	hSpCas9	negative selection	1220331
141480486	141480509	2	+	26627737	RPE1	viability after 12 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	2.733711457083043	[41]	[93,54]	9	hSpCas9	negative selection	1220332
141810362	141810385	2	+	26627737	RPE1	viability after 12 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.8191018075162106	[248]	[135,98]	5	hSpCas9	negative selection	1220333
142130672	142130695	2	-	26627737	RPE1	viability after 12 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-2.037242116590071	[1233]	[55,106]	-8	hSpCas9	negative selection	1220335
141055151	141055174	2	-	26627737	RPE1	viability after 15 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.31676899200541087	[2571]	[753,1052]	2	hSpCas9	negative selection	1302643
141062198	141062221	2	-	26627737	RPE1	viability after 15 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.05547698562385972	[1791]	[622,433]	0	hSpCas9	negative selection	1302644
141188509	141188532	2	+	26627737	RPE1	viability after 15 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	-0.7958759555258259	[1419]	[294,169]	-5	hSpCas9	negative selection	1302646
141480486	141480509	2	+	26627737	RPE1	viability after 15 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	3.521375347887231	[41]	[196,77]	9	hSpCas9	negative selection	1302647
141810362	141810385	2	+	26627737	RPE1	viability after 15 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.7743111941812931	[248]	[121,118]	5	hSpCas9	negative selection	1302648
142130672	142130695	2	-	26627737	RPE1	viability after 15 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-2.343401750425257	[1233]	[80,56]	-8	hSpCas9	negative selection	1302650
141055151	141055174	2	-	26627737	RPE1	viability after 18 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	-0.2546365827874262	[2571]	[502,665]	-2	hSpCas9	negative selection	1384958
141062198	141062221	2	-	26627737	RPE1	viability after 18 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	-0.1741124790251556	[1791]	[475,377]	-1	hSpCas9	negative selection	1384959
141188509	141188532	2	+	26627737	RPE1	viability after 18 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	-1.3498190751203674	[1419]	[247,45]	-7	hSpCas9	negative selection	1384961
141480486	141480509	2	+	26627737	RPE1	viability after 18 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	3.2736669194635355	[41]	[112,105]	9	hSpCas9	negative selection	1384962
141810362	141810385	2	+	26627737	RPE1	viability after 18 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.3542605140024979	[248]	[82,88]	2	hSpCas9	negative selection	1384963
142130672	142130695	2	-	26627737	RPE1	viability after 18 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-1.6198305070183057	[1233]	[74,143]	-7	hSpCas9	negative selection	1384965
141055151	141055174	2	-	26627737	HeLa	viability after 8 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.8079940000633112	[582]	[674,230,474]	6	hSpCas9	negative selection	1467273
141062198	141062221	2	-	26627737	HeLa	viability after 8 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	1.0493208129013625	[575]	[781,504,339]	7	hSpCas9	negative selection	1467274
141188509	141188532	2	+	26627737	HeLa	viability after 8 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	-0.09961270682813039	[617]	[447,107,240]	-1	hSpCas9	negative selection	1467276
141480486	141480509	2	+	26627737	HeLa	viability after 8 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	1.3128636895794878	[159]	[137,226,147]	8	hSpCas9	negative selection	1467277
141810362	141810385	2	+	26627737	HeLa	viability after 8 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	1.3419951736835172	[168]	[118,380,53]	8	hSpCas9	negative selection	1467278
142130672	142130695	2	-	26627737	HeLa	viability after 8 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-0.7106380226603635	[271]	[90,26,100]	-6	hSpCas9	negative selection	1467280
141055151	141055174	2	-	26627737	HeLa	viability after 12 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.8789446063229309	[582]	[187,450,681]	6	hSpCas9	negative selection	1549588
141062198	141062221	2	-	26627737	HeLa	viability after 12 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.3498629918518197	[575]	[306,361,234]	3	hSpCas9	negative selection	1549589
141188509	141188532	2	+	26627737	HeLa	viability after 12 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	-0.0009307778213504259	[617]	[245,230,290]	0	hSpCas9	negative selection	1549591
141480486	141480509	2	+	26627737	HeLa	viability after 12 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	1.2267804904153947	[159]	[114,202,139]	8	hSpCas9	negative selection	1549592
141810362	141810385	2	+	26627737	HeLa	viability after 12 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.437261241827651	[168]	[52,136,87]	4	hSpCas9	negative selection	1549593
142130672	142130695	2	-	26627737	HeLa	viability after 12 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-0.7961878670964591	[271]	[34,48,110]	-6	hSpCas9	negative selection	1549595
141055151	141055174	2	-	26627737	HeLa	viability after 15 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.6780606183201241	[582]	[269,232,658]	5	hSpCas9	negative selection	1631903
141062198	141062221	2	-	26627737	HeLa	viability after 15 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.7353877420543881	[575]	[470,249,453]	6	hSpCas9	negative selection	1631904
141188509	141188532	2	+	26627737	HeLa	viability after 15 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	-0.12558216710253434	[617]	[164,75,469]	-1	hSpCas9	negative selection	1631906
141480486	141480509	2	+	26627737	HeLa	viability after 15 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	0.5670828254254755	[159]	[81,191,8]	4	hSpCas9	negative selection	1631907
141810362	141810385	2	+	26627737	HeLa	viability after 15 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.5233001126571732	[168]	[121,127,41]	4	hSpCas9	negative selection	1631908
142130672	142130695	2	-	26627737	HeLa	viability after 15 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-1.2046180033008254	[271]	[75,16,50]	-8	hSpCas9	negative selection	1631910
141055151	141055174	2	-	26627737	HeLa	viability after 18 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.6972580712233041	[582]	[178,207,658]	5	hSpCas9	negative selection	1714218
141062198	141062221	2	-	26627737	HeLa	viability after 18 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.747437626871614	[575]	[323,204,453]	6	hSpCas9	negative selection	1714219
141188509	141188532	2	+	26627737	HeLa	viability after 18 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	-0.1517188942341713	[617]	[104,59,469]	-1	hSpCas9	negative selection	1714221
141480486	141480509	2	+	26627737	HeLa	viability after 18 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	0.5217698921498397	[159]	[49,157,8]	4	hSpCas9	negative selection	1714222
141810362	141810385	2	+	26627737	HeLa	viability after 18 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.49261428460718515	[168]	[72,111,41]	4	hSpCas9	negative selection	1714223
142130672	142130695	2	-	26627737	HeLa	viability after 18 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-1.2023766159601694	[271]	[51,12,50]	-8	hSpCas9	negative selection	1714225
141055151	141055174	2	-	26627737	HCT116	viability after 6 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.49302384933786003	[892]	[194,198]	2	hSpCas9	negative selection	1796533
141062198	141062221	2	-	26627737	HCT116	viability after 6 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	2.2678805952357664	[1523]	[440,1546]	9	hSpCas9	negative selection	1796534
141188509	141188532	2	+	26627737	HCT116	viability after 6 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	1.5849125536128081	[799]	[268,436]	7	hSpCas9	negative selection	1796536
141480486	141480509	2	+	26627737	HCT116	viability after 6 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	0.9149231200662993	[235]	[87,59]	5	hSpCas9	negative selection	1796537
141810362	141810385	2	+	26627737	HCT116	viability after 6 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	-1.2243997634186816	[106]	[12,3]	-6	hSpCas9	negative selection	1796538
142130672	142130695	2	-	26627737	HCT116	viability after 6 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	1.1173382107794694	[267]	[73,100]	6	hSpCas9	negative selection	1796540
141055151	141055174	2	-	26627737	HCT116	viability after 8 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.47235734513378497	[347]	[198,255,340]	5	hSpCas9	negative selection	1878848
141062198	141062221	2	-	26627737	HCT116	viability after 8 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	-0.17100882220205893	[720]	[342,323,390]	-2	hSpCas9	negative selection	1878849
141188509	141188532	2	+	26627737	HCT116	viability after 8 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	0.0261820146755245	[387]	[141,226,281]	0	hSpCas9	negative selection	1878851
141480486	141480509	2	+	26627737	HCT116	viability after 8 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	-0.3087538838879591	[221]	[130,78,86]	-4	hSpCas9	negative selection	1878852
141810362	141810385	2	+	26627737	HCT116	viability after 8 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.17210928575280704	[108]	[77,40,83]	2	hSpCas9	negative selection	1878853
142130672	142130695	2	-	26627737	HCT116	viability after 8 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-1.5506333674570327	[336]	[39,106,42]	-9	hSpCas9	negative selection	1878855
141055151	141055174	2	-	26627737	HCT116	viability after 9 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.6511391709720751	[892]	[350,392]	5	hSpCas9	negative selection	1961163
141062198	141062221	2	-	26627737	HCT116	viability after 9 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	-0.35409964691778606	[1523]	[414,241]	-2	hSpCas9	negative selection	1961164
141188509	141188532	2	+	26627737	HCT116	viability after 9 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	-0.5101343388783361	[799]	[254,66]	-4	hSpCas9	negative selection	1961166
141480486	141480509	2	+	26627737	HCT116	viability after 9 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	-2.152766148942792	[235]	[2,22]	-8	hSpCas9	negative selection	1961167
141810362	141810385	2	+	26627737	HCT116	viability after 9 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.5745947787527808	[106]	[22,57]	4	hSpCas9	negative selection	1961168
142130672	142130695	2	-	26627737	HCT116	viability after 9 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-1.2906235761683218	[267]	[64,0]	-7	hSpCas9	negative selection	1961170
141055151	141055174	2	-	26627737	HCT116	viability after 12 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.08236233715647795	[347]	[156,271,156]	0	hSpCas9	negative selection	2043478
141062198	141062221	2	-	26627737	HCT116	viability after 12 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	-0.16731721967186886	[720]	[346,320,342]	-2	hSpCas9	negative selection	2043479
141188509	141188532	2	+	26627737	HCT116	viability after 12 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	0.195077974587808	[387]	[130,386,194]	2	hSpCas9	negative selection	2043481
141480486	141480509	2	+	26627737	HCT116	viability after 12 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	-1.006830177827096	[221]	[17,111,48]	-8	hSpCas9	negative selection	2043482
141810362	141810385	2	+	26627737	HCT116	viability after 12 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.17741889015903123	[108]	[76,53,61]	1	hSpCas9	negative selection	2043483
142130672	142130695	2	-	26627737	HCT116	viability after 12 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-1.111261180895856	[336]	[41,145,62]	-8	hSpCas9	negative selection	2043485
141055151	141055174	2	-	26627737	HCT116	viability after 15 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.3538029033435564	[347]	[282,350,136]	3	hSpCas9	negative selection	2125793
141062198	141062221	2	-	26627737	HCT116	viability after 15 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	-0.08397551529627711	[720]	[565,294,332]	-1	hSpCas9	negative selection	2125794
141188509	141188532	2	+	26627737	HCT116	viability after 15 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	-0.1708392598435627	[387]	[166,219,202]	-2	hSpCas9	negative selection	2125796
141480486	141480509	2	+	26627737	HCT116	viability after 15 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	-0.493770516345979	[221]	[59,124,82]	-5	hSpCas9	negative selection	2125797
141810362	141810385	2	+	26627737	HCT116	viability after 15 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.39892589681498514	[108]	[97,27,122]	4	hSpCas9	negative selection	2125798
142130672	142130695	2	-	26627737	HCT116	viability after 15 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-1.3357352834612781	[336]	[56,123,46]	-8	hSpCas9	negative selection	2125800
141055151	141055174	2	-	26627737	HCT116	viability after 18 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	1.1236843761730348	[347]	[285,457,348]	8	hSpCas9	negative selection	2208108
141062198	141062221	2	-	26627737	HCT116	viability after 18 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.4361403889127089	[720]	[550,505,349]	4	hSpCas9	negative selection	2208109
141188509	141188532	2	+	26627737	HCT116	viability after 18 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	0.19891705053366487	[387]	[138,305,193]	1	hSpCas9	negative selection	2208111
141480486	141480509	2	+	26627737	HCT116	viability after 18 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	-1.0122984769495584	[221]	[24,52,82]	-7	hSpCas9	negative selection	2208112
141810362	141810385	2	+	26627737	HCT116	viability after 18 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.7298875978677588	[108]	[120,40,103]	6	hSpCas9	negative selection	2208113
142130672	142130695	2	-	26627737	HCT116	viability after 18 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-0.3868454320204021	[336]	[63,164,142]	-4	hSpCas9	negative selection	2208115
142130672	142130694	2	-	24717434	HeLa	essential genes for diphteria toxin toxicity	GGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	0.8635246881861306	[1625,1025,1517]	[0,0,0]	3	hSpCas9	positive selection	2381064
142130672	142130694	2	-	24717434	HeLa	essential genes for diphteria toxin toxicity	GGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	0.8635246881861306	[1625,1025,1517]	[0,0,0]	3	hSpCas9	positive selection	2381065
142130660	142130685	2	-	24717434	HeLa	essential genes for diphteria toxin toxicity	CCGATTGCCAGGGTGCTGACCGTGG	LRP1B	ENSG00000168702	-1.0970816331530437	[6574,4601,5072]	[0,0,0]	-8	hSpCas9	positive selection	2381066
142130660	142130685	2	-	24717434	HeLa	essential genes for diphteria toxin toxicity	CCGATTGCCAGGGTGCTGACCGTGG	LRP1B	ENSG00000168702	-1.0970816331530437	[6574,4601,5072]	[0,0,0]	-8	hSpCas9	positive selection	2381067
141480410	141480435	2	-	24717434	HeLa	essential genes for diphteria toxin toxicity	ACTGCCCAGATGGGTATGACGAAGG	LRP1B	ENSG00000168702	3.166850721460853	[4928,4207,3808]	[31,5,7]	6	hSpCas9	positive selection	2381068
141480410	141480435	2	-	24717434	HeLa	essential genes for diphteria toxin toxicity	ACTGCCCAGATGGGTATGACGAAGG	LRP1B	ENSG00000168702	3.166850721460853	[4928,4207,3808]	[31,5,7]	6	hSpCas9	positive selection	2381069
142130672	142130694	2	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	GGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	0.864163319001724	[1625,1025,1517]	[0,0,0]	2	hSpCas9	positive selection	2382328
142130672	142130694	2	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	GGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	0.864163319001724	[1625,1025,1517]	[0,0,0]	2	hSpCas9	positive selection	2382329
142130660	142130685	2	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	CCGATTGCCAGGGTGCTGACCGTGG	LRP1B	ENSG00000168702	-1.0970966892973988	[6574,4601,5072]	[0,0,0]	-9	hSpCas9	positive selection	2382330
142130660	142130685	2	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	CCGATTGCCAGGGTGCTGACCGTGG	LRP1B	ENSG00000168702	-1.0970966892973988	[6574,4601,5072]	[0,0,0]	-9	hSpCas9	positive selection	2382331
141480410	141480435	2	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	ACTGCCCAGATGGGTATGACGAAGG	LRP1B	ENSG00000168702	13.513505201388009	[4928,4207,3808]	[23735,29913,6265]	9	hSpCas9	positive selection	2382332
141480410	141480435	2	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	ACTGCCCAGATGGGTATGACGAAGG	LRP1B	ENSG00000168702	13.513505201388009	[4928,4207,3808]	[23735,29913,6265]	9	hSpCas9	positive selection	2382333
141818811	141818834	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCGTGAGCTACCGCACCTGG	LRP1B	ENSG00000168702	-0.46798260111423184	[1242,12]	[184,3]	-2	dCas9-VP64	positive selection	2387812
140610658	140610681	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCACTGCAAGCTCCACCTCCGGG	LRP1B	ENSG00000168702	-1.3954490623194618	[659,580]	[75,24]	-7	dCas9-VP64	positive selection	2391097
140295132	140295155	2	-	25494202	A375	resistance to PLX-4720 (puromycin)	TGTAATCCCAGCACTTTGAGAGG	LRP1B	ENSG00000168702	-0.7112509309644206	[46,33]	[6,2]	-4	dCas9-VP64	positive selection	2394239
141737140	141737163	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	TGAGGAATTTGAGACCAGCCTGG	LRP1B	ENSG00000168702	-0.3545855777379132	[130,359]	[7,79]	-2	dCas9-VP64	positive selection	2397906
141227033	141227056	2	-	25494202	A375	resistance to PLX-4720 (puromycin)	TTGTTGTTGTTGTTGTTGTTAGG	LRP1B	ENSG00000168702	-1.2553913082042603	[104,179]	[19,4]	-7	dCas9-VP64	positive selection	2401308
141593680	141593703	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	TGCAGTCCGCAGTCTGGCCTGGG	LRP1B	ENSG00000168702	1.4343036299875762	[392,325]	[62,376]	5	dCas9-VP64	positive selection	2404017
141421377	141421400	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	AAATTAGCCGGGCGTAGTGGCGG	LRP1B	ENSG00000168702	-0.8514681672512537	[13,97]	[5,6]	-5	dCas9-VP64	positive selection	2404284
140428817	140428840	2	-	25494202	A375	resistance to PLX-4720 (puromycin)	CTAAGTTGGCACCAGAGTTGTGG	LRP1B	ENSG00000168702	-0.9245438828404792	[27,124]	[11,4]	-5	dCas9-VP64	positive selection	2406917
140820255	140820278	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCATCAGCCACCACACCTGG	LRP1B	ENSG00000168702	3.13947332771205	[140,99]	[396,56]	8	dCas9-VP64	positive selection	2409199
140674014	140674037	2	-	25494202	A375	resistance to PLX-4720 (puromycin)	GCAGAGGTTGCAGTGAGCCAGAG	LRP1B	ENSG00000168702	1.1995393964604157	[18,52]	[7,28]	5	dCas9-VP64	positive selection	2409429
141622084	141622107	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	TTTCTCCATGTTGGTCAGGCAGG	LRP1B	ENSG00000168702	-2.2958931667653815	[393,165]	[8,14]	-9	dCas9-VP64	positive selection	2417394
141886920	141886943	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	TGTGTGTGTGTATGTGTGTGAGG	LRP1B	ENSG00000168702	1.195166826125428	[347,53]	[57,144]	5	dCas9-VP64	positive selection	2417937
141715425	141715448	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	TGTGCCACTGCACTCCAGTCCAG	LRP1B	ENSG00000168702	0.7065915118721766	[198,108]	[43,65]	3	dCas9-VP64	positive selection	2424067
140678801	140678824	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGAGTCTCTCTCTGTCGCCCGGG	LRP1B	ENSG00000168702	1.6026852076585545	[0,1]	[0,0]	6	dCas9-VP64	positive selection	2429626
141814306	141814329	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCAGGCTGTTCTTGGTTTGAAGG	LRP1B	ENSG00000168702	0.4620145810398085	[102,66]	[29,19]	2	dCas9-VP64	positive selection	2437559
141579980	141580003	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	GTGAGCCACCGCGCCCAGCCTGG	LRP1B	ENSG00000168702	-0.6476236116882323	[118,215]	[30,13]	-3	dCas9-VP64	positive selection	2438096
141846009	141846032	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	AAAGAGAGAGAGAGAGAGAACAG	LRP1B	ENSG00000168702	0.6316515901792452	[28,11]	[9,2]	2	dCas9-VP64	positive selection	2441166
140470568	140470591	2	-	25494202	A375	resistance to PLX-4720 (puromycin)	TCACTGCAAACTCCGCCTCCCAG	LRP1B	ENSG00000168702	-1.1801124495404707	[373,350]	[49,18]	-6	dCas9-VP64	positive selection	2448364
140772971	140772994	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	CACCTGTAATACCAACTACTCGG	LRP1B	ENSG00000168702	-0.20904487410036232	[411,186]	[69,40]	-1	dCas9-VP64	positive selection	2448701
142086373	142086396	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	GCCGAGGTGGACGGATCACGAGG	LRP1B	ENSG00000168702	0.16474050611641577	[16,25]	[4,4]	0	dCas9-VP64	positive selection	2448761
140990112	140990135	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGAGAATCGCTTGAACCCAAG	LRP1B	ENSG00000168702	-1.1949452889942442	[147,110]	[6,17]	-7	dCas9-VP64	positive selection	2450022
141185984	141186007	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGAGAATCGCTTGAACCCTGG	LRP1B	ENSG00000168702	-1.1949452889942442	[147,110]	[6,17]	-7	dCas9-VP64	positive selection	2450153
141650148	141650171	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCAGCCTGGGTGACAGAGCAAAG	LRP1B	ENSG00000168702	-0.21879118015331467	[3,55]	[3,6]	-1	dCas9-VP64	positive selection	2450562
141186006	141186029	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	GAGGCAGAGGTTGCAGTGAGAGG	LRP1B	ENSG00000168702	2.8458860914044886	[4,6]	[4,13]	8	dCas9-VP64	positive selection	2464610
140964302	140964325	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	ATCACAGGGAGACAGGCCTCCGG	LRP1B	ENSG00000168702	-0.5128660059315574	[210,125]	[31,18]	-2	dCas9-VP64	positive selection	2471081
140772981	140773004	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	ACCAACTACTCGGGAGGCTGAGG	LRP1B	ENSG00000168702	-0.5304241382685226	[52,15]	[7,0]	-3	dCas9-VP64	positive selection	2474362
141488532	141488555	2	+	25494202	A375	resistance to PLX-4720 (puromycin)	CACTGCAGCCTTGACCTCCCTGG	LRP1B	ENSG00000168702	-0.13547020725059378	[412,709]	[41,189]	0	dCas9-VP64	positive selection	2474502
140320807	140320830	2	-	25494202	A375	resistance to PLX-4720 (puromycin)	CTCAGGTGATCCGCCTGCCTAAG	LRP1B	ENSG00000168702	-1.0260640950785338	[143,176]	[21,11]	-6	dCas9-VP64	positive selection	2475164
141818811	141818834	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCGTGAGCTACCGCACCTGG	LRP1B	ENSG00000168702	0.19591410252065838	[56,235]	[12,91]	1	dCas9-VP64	positive selection	2483067
140610658	140610681	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCACTGCAAGCTCCACCTCCGGG	LRP1B	ENSG00000168702	0.22022123063307442	[237,267]	[67,121]	1	dCas9-VP64	positive selection	2486352
140295132	140295155	2	-	25494202	A375	resistance to PLX-4720 (zeocin)	TGTAATCCCAGCACTTTGAGAGG	LRP1B	ENSG00000168702	-0.5384167306991928	[64,169]	[16,33]	-5	dCas9-VP64	positive selection	2489494
141737140	141737163	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	TGAGGAATTTGAGACCAGCCTGG	LRP1B	ENSG00000168702	0.5456180239884447	[52,30]	[16,22]	4	dCas9-VP64	positive selection	2493161
141227033	141227056	2	-	25494202	A375	resistance to PLX-4720 (zeocin)	TTGTTGTTGTTGTTGTTGTTAGG	LRP1B	ENSG00000168702	-0.6691815338040683	[248,92]	[41,27]	-6	dCas9-VP64	positive selection	2496563
141593680	141593703	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	TGCAGTCCGCAGTCTGGCCTGGG	LRP1B	ENSG00000168702	-0.2809677616647409	[196,65]	[40,29]	-3	dCas9-VP64	positive selection	2499272
141421377	141421400	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	AAATTAGCCGGGCGTAGTGGCGG	LRP1B	ENSG00000168702	0.40157018881037165	[169,39]	[83,8]	3	dCas9-VP64	positive selection	2499539
140428817	140428840	2	-	25494202	A375	resistance to PLX-4720 (zeocin)	CTAAGTTGGCACCAGAGTTGTGG	LRP1B	ENSG00000168702	1.4514715903805788	[109,48]	[33,106]	7	dCas9-VP64	positive selection	2502172
140820255	140820278	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCATCAGCCACCACACCTGG	LRP1B	ENSG00000168702	2.698989317197104	[135,124]	[110,433]	9	dCas9-VP64	positive selection	2504454
140674014	140674037	2	-	25494202	A375	resistance to PLX-4720 (zeocin)	GCAGAGGTTGCAGTGAGCCAGAG	LRP1B	ENSG00000168702	-0.6764771816619682	[119,87]	[20,20]	-6	dCas9-VP64	positive selection	2504684
141622084	141622107	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	TTTCTCCATGTTGGTCAGGCAGG	LRP1B	ENSG00000168702	0.6223741115754664	[126,133]	[38,89]	4	dCas9-VP64	positive selection	2512649
141886920	141886943	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	TGTGTGTGTGTATGTGTGTGAGG	LRP1B	ENSG00000168702	-0.09077218876109017	[446,496]	[116,169]	0	dCas9-VP64	positive selection	2513192
141715425	141715448	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	TGTGCCACTGCACTCCAGTCCAG	LRP1B	ENSG00000168702	-0.12403431172340174	[312,117]	[32,93]	-1	dCas9-VP64	positive selection	2519322
140678801	140678824	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGAGTCTCTCTCTGTCGCCCGGG	LRP1B	ENSG00000168702	0.31611073697098746	[6,38]	[2,13]	2	dCas9-VP64	positive selection	2524881
141814306	141814329	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCAGGCTGTTCTTGGTTTGAAGG	LRP1B	ENSG00000168702	-0.8040202208265178	[94,159]	[24,21]	-7	dCas9-VP64	positive selection	2532814
141579980	141580003	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	GTGAGCCACCGCGCCCAGCCTGG	LRP1B	ENSG00000168702	-0.5349507089340686	[327,308]	[84,58]	-5	dCas9-VP64	positive selection	2533351
141846009	141846032	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	AAAGAGAGAGAGAGAGAGAACAG	LRP1B	ENSG00000168702	0.43533825533627796	[75,43]	[28,22]	3	dCas9-VP64	positive selection	2536421
140470568	140470591	2	-	25494202	A375	resistance to PLX-4720 (zeocin)	TCACTGCAAACTCCGCCTCCCAG	LRP1B	ENSG00000168702	1.4145647280039761	[84,145]	[146,55]	7	dCas9-VP64	positive selection	2543619
140772971	140772994	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	CACCTGTAATACCAACTACTCGG	LRP1B	ENSG00000168702	0.7947980887601276	[215,263]	[62,203]	5	dCas9-VP64	positive selection	2543956
142086373	142086396	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	GCCGAGGTGGACGGATCACGAGG	LRP1B	ENSG00000168702	0.6847734529827498	[13,14]	[8,5]	5	dCas9-VP64	positive selection	2544016
140990112	140990135	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGAGAATCGCTTGAACCCAAG	LRP1B	ENSG00000168702	1.2597172262171965	[381,372]	[459,141]	7	dCas9-VP64	positive selection	2545277
141185984	141186007	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGAGAATCGCTTGAACCCTGG	LRP1B	ENSG00000168702	1.2597172262171965	[381,372]	[459,141]	7	dCas9-VP64	positive selection	2545408
141650148	141650171	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCAGCCTGGGTGACAGAGCAAAG	LRP1B	ENSG00000168702	1.4992476200347653	[28,23]	[15,31]	8	dCas9-VP64	positive selection	2545817
141186006	141186029	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	GAGGCAGAGGTTGCAGTGAGAGG	LRP1B	ENSG00000168702	0.5694698539005818	[43,11]	[11,14]	4	dCas9-VP64	positive selection	2559865
140964302	140964325	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	ATCACAGGGAGACAGGCCTCCGG	LRP1B	ENSG00000168702	0.03705330659255135	[204,230]	[34,107]	0	dCas9-VP64	positive selection	2566336
140772981	140773004	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	ACCAACTACTCGGGAGGCTGAGG	LRP1B	ENSG00000168702	-0.09188539124364214	[49,15]	[10,8]	0	dCas9-VP64	positive selection	2569617
141488532	141488555	2	+	25494202	A375	resistance to PLX-4720 (zeocin)	CACTGCAGCCTTGACCTCCCTGG	LRP1B	ENSG00000168702	0.2584978845854493	[172,83]	[35,62]	2	dCas9-VP64	positive selection	2569757
140320807	140320830	2	-	25494202	A375	resistance to PLX-4720 (zeocin)	CTCAGGTGATCCGCCTGCCTAAG	LRP1B	ENSG00000168702	0.2626572524246065	[103,174]	[69,39]	2	dCas9-VP64	positive selection	2570419
140867775	140867798	2	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	AACATGATAGAAATCATCCGAGG	LRP1B	ENSG00000168702	0.7342405516641712	[2,2]	[3,4]	9	hSpCas9	positive selection	2999988
140868208	140868231	2	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	ATAGAGGCAGATTCAATGCGAGG	LRP1B	ENSG00000168702	0.1979014487718408	[4,4]	[4,4]	4	hSpCas9	positive selection	2999989
141049083	141049106	2	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CGTGAAAGTCTAAAGCACGAGGG	LRP1B	ENSG00000168702	0.6413399421107598	[2,2]	[3,4]	9	hSpCas9	positive selection	2999990
140886158	140886181	2	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	-0.9180468797008792	[1,1]	[0,0]	-9	hSpCas9	positive selection	2999991
140867775	140867798	2	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	AACATGATAGAAATCATCCGAGG	LRP1B	ENSG00000168702	0.057081751867043506	[2,2]	[2,0]	1	hSpCas9	positive selection	3067846
140868208	140868231	2	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	ATAGAGGCAGATTCAATGCGAGG	LRP1B	ENSG00000168702	0.18520195879046852	[4,4]	[4,3]	3	hSpCas9	positive selection	3067847
141049083	141049106	2	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CGTGAAAGTCTAAAGCACGAGGG	LRP1B	ENSG00000168702	-0.1487078285456669	[2,2]	[3,0]	-2	hSpCas9	positive selection	3067848
140886158	140886181	2	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	0.03217301423233376	[1,1]	[0,0]	0	hSpCas9	positive selection	3067849
141810287	141810310		+	24336571	A375	resistance to PLX after 7 days	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	-0.2097515909717128	[7,13]	[7,9]	-6	hSpCas9	positive selection	3125194
141810345	141810368		+	24336571	A375	resistance to PLX after 7 days	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.06061935963950338	[19,17]	[18,16]	-2	hSpCas9	positive selection	3125195
140982237	140982260		-	24336571	A375	resistance to PLX after 7 days	GACCAGTTTTCTTGCGGAAATGG	LRP1B	ENSG00000168702	-0.382577807290959	[6,5]	[3,4]	-9	hSpCas9	positive selection	3125196
140982235	140982258		+	24336571	A375	resistance to PLX after 7 days	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.32799308956300255	[4,4]	[4,6]	8	hSpCas9	positive selection	3125197
141810334	141810357		-	24336571	A375	resistance to PLX after 7 days	TGACTTGTGTCTCCCAGAGCTGG	LRP1B	ENSG00000168702	-0.05216094768985547	[13,12]	[12,11]	-1	hSpCas9	positive selection	3125198
141810287	141810310		+	24336571	A375	resistance to PLX after 14 days	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	-0.4961621200133848	[8,8]	[2,1]	-6	hSpCas9	positive selection	3182987
141810345	141810368		+	24336571	A375	resistance to PLX after 14 days	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.1189195451974494	[18,18]	[8,9]	1	hSpCas9	positive selection	3182988
140982237	140982260		-	24336571	A375	resistance to PLX after 14 days	GACCAGTTTTCTTGCGGAAATGG	LRP1B	ENSG00000168702	0.6570673778826541	[4,2]	[2,2]	6	hSpCas9	positive selection	3182989
140982235	140982258		+	24336571	A375	resistance to PLX after 14 days	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.9110475881334594	[3,2]	[2,3]	7	hSpCas9	positive selection	3182990
141810334	141810357		-	24336571	A375	resistance to PLX after 14 days	TGACTTGTGTCTCCCAGAGCTGG	LRP1B	ENSG00000168702	-0.09887355389219044	[6,11]	[3,3]	-1	hSpCas9	positive selection	3182991
141810287	141810310		+	24336571	A375	viability after 7 days	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.10410624437252392	[9]	[7,13]	1	hSpCas9	negative selection	3240780
141810345	141810368		+	24336571	A375	viability after 7 days	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	1.0188296671509458	[9]	[19,17]	9	hSpCas9	negative selection	3240781
140982237	140982260		-	24336571	A375	viability after 7 days	GACCAGTTTTCTTGCGGAAATGG	LRP1B	ENSG00000168702	0.32252324531443055	[4]	[6,5]	5	hSpCas9	negative selection	3240782
140982235	140982258		+	24336571	A375	viability after 7 days	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.15228413677993902	[5]	[4,4]	-2	hSpCas9	negative selection	3240783
141810334	141810357		-	24336571	A375	viability after 7 days	TGACTTGTGTCTCCCAGAGCTGG	LRP1B	ENSG00000168702	-0.11764176065284959	[14]	[13,12]	-2	hSpCas9	negative selection	3240784
141810287	141810310		+	24336571	A375	viability after 14 days	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	-0.15675335658668743	[9]	[8,8]	-2	hSpCas9	negative selection	3298573
141810345	141810368		+	24336571	A375	viability after 14 days	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	1.0400179931035174	[9]	[18,18]	9	hSpCas9	negative selection	3298574
140982237	140982260		-	24336571	A375	viability after 14 days	GACCAGTTTTCTTGCGGAAATGG	LRP1B	ENSG00000168702	-0.3262626141583653	[4]	[4,2]	-4	hSpCas9	negative selection	3298575
140982235	140982258		+	24336571	A375	viability after 14 days	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.45485825113197453	[5]	[3,2]	-5	hSpCas9	negative selection	3298576
141810334	141810357		-	24336571	A375	viability after 14 days	TGACTTGTGTCTCCCAGAGCTGG	LRP1B	ENSG00000168702	-0.5681341078089438	[14]	[6,11]	-6	hSpCas9	negative selection	3298577
140982235	140982258	2	+	27383988	293T	resistance to West Nile virus (flavivirus)	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.11777485904704146	[140,140]	[0,0]	0	hSpCas9	positive selection	3377566
141810287	141810310	2	+	27383988	293T	resistance to West Nile virus (flavivirus)	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	3.0576538666094706	[146,146]	[7,7]	8	hSpCas9	positive selection	3377567
140982169	140982192	2	-	27383988	293T	resistance to West Nile virus (flavivirus)	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	-0.3425866307412928	[193,193]	[0,0]	-2	hSpCas9	positive selection	3377568
140867775	140867798	2	-	26780180	HT29	viability (Avana library 4 designs)	AACATGATAGAAATCATCCGAGG	LRP1B	ENSG00000168702	1.90857176437915	[]	[]	7	hSpCas9	negative selection	3437557
140868207	140868230	2	+	26780180	HT29	viability (Avana library 4 designs)	ATAGAGGCAGATTCAATGCGAGG	LRP1B	ENSG00000168702	0.0694933183216551	[]	[]	0	hSpCas9	negative selection	3437558
141049082	141049105	2	+	26780180	HT29	viability (Avana library 4 designs)	CGTGAAAGTCTAAAGCACGAGGG	LRP1B	ENSG00000168702	1.859475452629	[]	[]	7	hSpCas9	negative selection	3437559
140886158	140886181	2	-	26780180	HT29	viability (Avana library 4 designs)	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	1.42598066659147	[]	[]	5	hSpCas9	negative selection	3437560
140868207	140868230	2	+	26780180	A375	viability (Avana lentiCRISPRv2)	ATAGAGGCAGATTCAATGCGAGG	LRP1B	ENSG00000168702	4.78793445666458	[]	[]	7	hSpCas9	negative selection	3526337
141049082	141049105	2	+	26780180	A375	viability (Avana lentiCRISPRv2)	CGTGAAAGTCTAAAGCACGAGGG	LRP1B	ENSG00000168702	-1.57128344488681	[]	[]	-2	hSpCas9	negative selection	3526338
140886158	140886181	2	-	26780180	A375	viability (Avana lentiCRISPRv2)	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	-2.22200405490706	[]	[]	-3	hSpCas9	negative selection	3526339
140867775	140867798	2	-	26780180	A375	viability (Avana lentiCRISPRv2)	AACATGATAGAAATCATCCGAGG	LRP1B	ENSG00000168702	-2.17823580181863	[]	[]	-3	hSpCas9	negative selection	3526340
140776175	140776198	2	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGAACCTGCAGCAAAAGAGACGG	LRP1B	ENSG00000168702	-8.44804294151738	[]	[]	-7	hSpCas9	negative selection	3526341
141019946	141019969	2	-	26780180	A375	viability (Avana lentiCRISPRv2)	GGTGAAATGTCTCATCCCAGAGG	LRP1B	ENSG00000168702	2.07525292972299	[]	[]	3	hSpCas9	negative selection	3526342
140868207	140868230	2	+	26780180	A375	viability (Avana lentiGuide)	ATAGAGGCAGATTCAATGCGAGG	LRP1B	ENSG00000168702	-2.46386108496047	[]	[]	-4	hSpCas9	negative selection	3634996
141049082	141049105	2	+	26780180	A375	viability (Avana lentiGuide)	CGTGAAAGTCTAAAGCACGAGGG	LRP1B	ENSG00000168702	-3.68536234991094	[]	[]	-6	hSpCas9	negative selection	3634997
140886158	140886181	2	-	26780180	A375	viability (Avana lentiGuide)	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	12.0614308133601	[]	[]	7	hSpCas9	negative selection	3634998
140867775	140867798	2	-	26780180	A375	viability (Avana lentiGuide)	AACATGATAGAAATCATCCGAGG	LRP1B	ENSG00000168702	9.95211847559416	[]	[]	7	hSpCas9	negative selection	3634999
140776175	140776198	2	-	26780180	A375	viability (Avana lentiGuide)	GGAACCTGCAGCAAAAGAGACGG	LRP1B	ENSG00000168702	-5.45202215750114	[]	[]	-8	hSpCas9	negative selection	3635000
141019946	141019969	2	-	26780180	A375	viability (Avana lentiGuide)	GGTGAAATGTCTCATCCCAGAGG	LRP1B	ENSG00000168702	-5.38485542206081	[]	[]	-8	hSpCas9	negative selection	3635001
140868207	140868230	2	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	ATAGAGGCAGATTCAATGCGAGG	LRP1B	ENSG00000168702	0.15580626539034242	[6]	[7,6]	4	hSpCas9	positive selection	3743655
141049082	141049105	2	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CGTGAAAGTCTAAAGCACGAGGG	LRP1B	ENSG00000168702	-0.658268332701652	[4]	[3,1]	-7	hSpCas9	positive selection	3743656
140886158	140886181	2	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	-1.1521078347441434	[4]	[1,0]	-9	hSpCas9	positive selection	3743657
140867775	140867798	2	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	AACATGATAGAAATCATCCGAGG	LRP1B	ENSG00000168702	-0.37430821887304944	[5]	[4,3]	-5	hSpCas9	positive selection	3743658
140776175	140776198	2	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGAACCTGCAGCAAAAGAGACGG	LRP1B	ENSG00000168702	-0.2542381615632493	[4]	[4,2]	-4	hSpCas9	positive selection	3743659
141019946	141019969	2	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGTGAAATGTCTCATCCCAGAGG	LRP1B	ENSG00000168702	0.1475476332042207	[4]	[5,4]	4	hSpCas9	positive selection	3743660
140868207	140868230	2	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	ATAGAGGCAGATTCAATGCGAGG	LRP1B	ENSG00000168702	0.16975669889408418	[6]	[6,5]	4	hSpCas9	positive selection	3852262
141049082	141049105	2	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CGTGAAAGTCTAAAGCACGAGGG	LRP1B	ENSG00000168702	-0.736843624336272	[4]	[1,2]	-7	hSpCas9	positive selection	3852263
140886158	140886181	2	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	-1.8811239131101236	[3]	[0,0]	-9	hSpCas9	positive selection	3852264
140867775	140867798	2	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	AACATGATAGAAATCATCCGAGG	LRP1B	ENSG00000168702	-0.04560677037141264	[4]	[3,2]	0	hSpCas9	positive selection	3852265
140776175	140776198	2	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGAACCTGCAGCAAAAGAGACGG	LRP1B	ENSG00000168702	0.20420406438165833	[5]	[4,4]	5	hSpCas9	positive selection	3852266
141019946	141019969	2	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGTGAAATGTCTCATCCCAGAGG	LRP1B	ENSG00000168702	0.16566623760593507	[4]	[4,3]	4	hSpCas9	positive selection	3852267
141810287	141810310	2	+	26780180	A375	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	1.26325189383091	[]	[]	6	hSpCas9	negative selection	3957914
140951895	140951918	2	-	26780180	A375	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	0.179566431539002	[]	[]	0	hSpCas9	negative selection	3957915
141810345	141810368	2	+	26780180	A375	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.865593161822184	[]	[]	3	hSpCas9	negative selection	3957916
140951859	140951882	2	-	26780180	A375	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	1.18912749830501	[]	[]	6	hSpCas9	negative selection	3957917
140982235	140982258	2	+	26780180	A375	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	1.40949843456193	[]	[]	7	hSpCas9	negative selection	3957918
140982169	140982192	2	-	26780180	A375	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	1.1120552667851	[]	[]	5	hSpCas9	negative selection	3957919
141810287	141810310	2	+	26780180	HT29	viability (GeCKOv2 library)	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.713078277114267	[]	[]	2	hSpCas9	negative selection	4065880
140951895	140951918	2	-	26780180	HT29	viability (GeCKOv2 library)	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	0.240624092418841	[]	[]	0	hSpCas9	negative selection	4065881
141810345	141810368	2	+	26780180	HT29	viability (GeCKOv2 library)	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	1.05004321060921	[]	[]	5	hSpCas9	negative selection	4065882
140951859	140951882	2	-	26780180	HT29	viability (GeCKOv2 library)	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	2.3054947109228	[]	[]	9	hSpCas9	negative selection	4065883
140982235	140982258	2	+	26780180	HT29	viability (GeCKOv2 library)	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	1.24724514214087	[]	[]	6	hSpCas9	negative selection	4065884
140982169	140982192	2	-	26780180	HT29	viability (GeCKOv2 library)	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	1.41885887631001	[]	[]	7	hSpCas9	negative selection	4065885
141810287	141810310	2	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	-0.030919840922077862	[3]	[2,1]	0	hSpCas9	positive selection	4149309
141810345	141810368	2	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.25543329497216855	[4]	[3,3]	6	hSpCas9	positive selection	4149310
140982237	140982260	2	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GACCAGTTTTCTTGCGGAAATGG	LRP1B	ENSG00000168702	0.07746332748277046	[2]	[2,1]	2	hSpCas9	positive selection	4149311
140982235	140982258	2	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.33871176699637096	[2]	[0,1]	-7	hSpCas9	positive selection	4149312
141810334	141810357	2	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TGACTTGTGTCTCCCAGAGCTGG	LRP1B	ENSG00000168702	0.01820098175614163	[3]	[2,1]	0	hSpCas9	positive selection	4149313
141810287	141810310	2	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.7138740364655427	[2]	[3,2,1,0]	4	hSpCas9	positive selection	4213331
141810345	141810368	2	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.45525857753871257	[3]	[3,1,4,0]	3	hSpCas9	positive selection	4213332
140982237	140982260	2	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GACCAGTTTTCTTGCGGAAATGG	LRP1B	ENSG00000168702	1.5417938521071806	[2]	[2,2,0,3]	9	hSpCas9	positive selection	4213333
140982235	140982258	2	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	1.9920654664161197	[1]	[1,2,0,3]	9	hSpCas9	positive selection	4213334
141810334	141810357	2	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TGACTTGTGTCTCCCAGAGCTGG	LRP1B	ENSG00000168702	-0.30041256635778624	[3]	[3,0,0,0]	-4	hSpCas9	positive selection	4213335
140951895	140951918	2	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	0.07690363782950138	[0]	[0,0]	1	hSpCas9	positive selection	4280868
141810345	141810368	2	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.03648967765272998	[3]	[3,2]	0	hSpCas9	positive selection	4280869
140951859	140951882	2	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	-0.23571734024042532	[2]	[2,0]	-5	hSpCas9	positive selection	4280870
140833638	140833661	2	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.5174786129511587	[4]	[5,4]	9	hSpCas9	positive selection	4312349
140704933	140704956	2	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.7293518280699013	[2]	[4,3]	9	hSpCas9	positive selection	4315665
140586627	140586650	2	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	-0.3920195619201358	[2]	[2,0]	-7	hSpCas9	positive selection	4317463
140586669	140586692	2	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.5920502063756593	[2]	[3,3]	9	hSpCas9	positive selection	4317464
140586623	140586646	2	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.30953093039049706	[3]	[3,0]	-6	hSpCas9	positive selection	4317465
140586672	140586695	2	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.42320079718950865	[3]	[4,3]	8	hSpCas9	positive selection	4317466
140982235	140982258	2	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.09376723153900057	[2]	[3,0]	-2	hSpCas9	positive selection	4345127
141810287	141810310	2	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.38837568759076635	[2]	[3,1]	7	hSpCas9	positive selection	4345128
140982169	140982192	2	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.2893399892060811	[2]	[2,2]	6	hSpCas9	positive selection	4345129
140776142	140776164	2	+	27760321	OCIAML3	viability	GAAGTCTTATTCCGTAGGATGG	LRP1B	ENSG00000168702	0.1839564158470135	[143,97]	[80,138]	2	hSpCas9	negative selection	4415134
140883946	140883968	2	-	27760321	OCIAML3	viability	TGACAGTCGACTGGATAGCAGG	LRP1B	ENSG00000168702	-0.6882241290387527	[397,350]	[180,181]	-6	hSpCas9	negative selection	4415135
140903141	140903163	2	-	27760321	OCIAML3	viability	AGTGTTCGCTGAACAATGGAGG	LRP1B	ENSG00000168702	-0.03380737147886449	[449,380]	[291,347]	0	hSpCas9	negative selection	4415136
141013695	141013717	2	+	27760321	OCIAML3	viability	ATGATGCGACAGTCCGAAAGGG	LRP1B	ENSG00000168702	0.29653420159406385	[261,218]	[167,310]	3	hSpCas9	negative selection	4415137
141015779	141015801	2	-	27760321	OCIAML3	viability	TGGCCAAACGGTTTAACTCTGG	LRP1B	ENSG00000168702	0.6450258945823637	[323,246]	[299,406]	7	hSpCas9	negative selection	4415138
140776142	140776164	2	+	27760321	OCIAML2	viability	GAAGTCTTATTCCGTAGGATGG	LRP1B	ENSG00000168702	-0.37118365132485676	[143,97]	[69,80]	-4	hSpCas9	negative selection	4498597
140883946	140883968	2	-	27760321	OCIAML2	viability	TGACAGTCGACTGGATAGCAGG	LRP1B	ENSG00000168702	0.3247240929520431	[397,350]	[439,297]	4	hSpCas9	negative selection	4498598
140903141	140903163	2	-	27760321	OCIAML2	viability	AGTGTTCGCTGAACAATGGAGG	LRP1B	ENSG00000168702	0.14399174779245363	[449,380]	[335,414]	2	hSpCas9	negative selection	4498599
141013695	141013717	2	+	27760321	OCIAML2	viability	ATGATGCGACAGTCCGAAAGGG	LRP1B	ENSG00000168702	0.5268447706190721	[261,218]	[232,339]	7	hSpCas9	negative selection	4498600
141015779	141015801	2	-	27760321	OCIAML2	viability	TGGCCAAACGGTTTAACTCTGG	LRP1B	ENSG00000168702	-0.06802832535379566	[323,246]	[171,279]	-1	hSpCas9	negative selection	4498601
140776142	140776164	2	+	27760321	MV411	viability	GAAGTCTTATTCCGTAGGATGG	LRP1B	ENSG00000168702	-0.41323460570102566	[143,97]	[85,18]	-3	hSpCas9	negative selection	4582060
140883946	140883968	2	-	27760321	MV411	viability	TGACAGTCGACTGGATAGCAGG	LRP1B	ENSG00000168702	0.15603981557377752	[397,350]	[90,550]	1	hSpCas9	negative selection	4582061
140903141	140903163	2	-	27760321	MV411	viability	AGTGTTCGCTGAACAATGGAGG	LRP1B	ENSG00000168702	-0.9226349050540528	[449,380]	[66,259]	-6	hSpCas9	negative selection	4582062
141013695	141013717	2	+	27760321	MV411	viability	ATGATGCGACAGTCCGAAAGGG	LRP1B	ENSG00000168702	-0.2646432698359861	[261,218]	[97,181]	-2	hSpCas9	negative selection	4582063
141015779	141015801	2	-	27760321	MV411	viability	TGGCCAAACGGTTTAACTCTGG	LRP1B	ENSG00000168702	0.11546257298613127	[323,246]	[335,1]	0	hSpCas9	negative selection	4582064
140776142	140776164	2	+	27760321	HL60	viability	GAAGTCTTATTCCGTAGGATGG	LRP1B	ENSG00000168702	0.8137553598727767	[143,97]	[174,167]	8	hSpCas9	negative selection	4665523
140883946	140883968	2	-	27760321	HL60	viability	TGACAGTCGACTGGATAGCAGG	LRP1B	ENSG00000168702	0.18959701784029892	[397,350]	[239,462]	2	hSpCas9	negative selection	4665524
140903141	140903163	2	-	27760321	HL60	viability	AGTGTTCGCTGAACAATGGAGG	LRP1B	ENSG00000168702	-0.2309449061237774	[449,380]	[343,228]	-3	hSpCas9	negative selection	4665525
141013695	141013717	2	+	27760321	HL60	viability	ATGATGCGACAGTCCGAAAGGG	LRP1B	ENSG00000168702	-0.5331740857126163	[261,218]	[108,162]	-5	hSpCas9	negative selection	4665526
141015779	141015801	2	-	27760321	HL60	viability	TGGCCAAACGGTTTAACTCTGG	LRP1B	ENSG00000168702	-0.10820500217144291	[323,246]	[170,260]	-1	hSpCas9	negative selection	4665527
140776142	140776164	2	+	27760321	HT1080	viability	GAAGTCTTATTCCGTAGGATGG	LRP1B	ENSG00000168702	-0.0648981782746989	[97,76]	[50,13]	0	hSpCas9	negative selection	4748986
140883946	140883968	2	-	27760321	HT1080	viability	TGACAGTCGACTGGATAGCAGG	LRP1B	ENSG00000168702	0.3347067481894516	[350,273]	[156,156]	1	hSpCas9	negative selection	4748987
140903141	140903163	2	-	27760321	HT1080	viability	AGTGTTCGCTGAACAATGGAGG	LRP1B	ENSG00000168702	0.10217082880722006	[380,297]	[85,209]	0	hSpCas9	negative selection	4748988
141013695	141013717	2	+	27760321	HT1080	viability	ATGATGCGACAGTCCGAAAGGG	LRP1B	ENSG00000168702	0.663001118824994	[218,170]	[101,145]	3	hSpCas9	negative selection	4748989
141015779	141015801	2	-	27760321	HT1080	viability	TGGCCAAACGGTTTAACTCTGG	LRP1B	ENSG00000168702	-0.07757840753555434	[246,192]	[136,23]	0	hSpCas9	negative selection	4748990
140776142	140776164	2	+	27760321	HT29	viability after 7 days	GAAGTCTTATTCCGTAGGATGG	LRP1B	ENSG00000168702	0.028957575472346786	[97,76]	[91,163,85]	0	hSpCas9	negative selection	4832449
140883946	140883968	2	-	27760321	HT29	viability after 7 days	TGACAGTCGACTGGATAGCAGG	LRP1B	ENSG00000168702	-0.48277589771622326	[350,273]	[423,277,182]	-6	hSpCas9	negative selection	4832450
140903141	140903163	2	-	27760321	HT29	viability after 7 days	AGTGTTCGCTGAACAATGGAGG	LRP1B	ENSG00000168702	-0.5529633997657574	[380,297]	[173,159,532]	-7	hSpCas9	negative selection	4832451
141013695	141013717	2	+	27760321	HT29	viability after 7 days	ATGATGCGACAGTCCGAAAGGG	LRP1B	ENSG00000168702	0.42489572829548516	[218,170]	[195,512,281]	6	hSpCas9	negative selection	4832452
141015779	141015801	2	-	27760321	HT29	viability after 7 days	TGGCCAAACGGTTTAACTCTGG	LRP1B	ENSG00000168702	-0.2622505818081666	[246,192]	[319,155,242]	-4	hSpCas9	negative selection	4832453
140776142	140776164	2	+	27760321	HT29	viability after 25 days	GAAGTCTTATTCCGTAGGATGG	LRP1B	ENSG00000168702	0.7305940955551526	[97,76]	[219,93,181]	8	hSpCas9	negative selection	4915912
140883946	140883968	2	-	27760321	HT29	viability after 25 days	TGACAGTCGACTGGATAGCAGG	LRP1B	ENSG00000168702	0.0061397539413200475	[350,273]	[276,380,429]	0	hSpCas9	negative selection	4915913
140903141	140903163	2	-	27760321	HT29	viability after 25 days	AGTGTTCGCTGAACAATGGAGG	LRP1B	ENSG00000168702	-0.5377194739859525	[380,297]	[231,327,240]	-5	hSpCas9	negative selection	4915914
141013695	141013717	2	+	27760321	HT29	viability after 25 days	ATGATGCGACAGTCCGAAAGGG	LRP1B	ENSG00000168702	-0.0018454550804335446	[218,170]	[132,196,356]	0	hSpCas9	negative selection	4915915
141015779	141015801	2	-	27760321	HT29	viability after 25 days	TGGCCAAACGGTTTAACTCTGG	LRP1B	ENSG00000168702	0.041885965304364614	[246,192]	[232,283,260]	0	hSpCas9	negative selection	4915916
140776142	140776164	2	+	27760321	HT29	viability after 22 days	GAAGTCTTATTCCGTAGGATGG	LRP1B	ENSG00000168702	0.19713393030505366	[97,76]	[46,71,231]	2	hSpCas9	negative selection	4999375
140883946	140883968	2	-	27760321	HT29	viability after 22 days	TGACAGTCGACTGGATAGCAGG	LRP1B	ENSG00000168702	0.42993108374732164	[350,273]	[470,552,435]	4	hSpCas9	negative selection	4999376
140903141	140903163	2	-	27760321	HT29	viability after 22 days	AGTGTTCGCTGAACAATGGAGG	LRP1B	ENSG00000168702	-0.1389341104379225	[380,297]	[184,542,345]	-1	hSpCas9	negative selection	4999377
141013695	141013717	2	+	27760321	HT29	viability after 22 days	ATGATGCGACAGTCCGAAAGGG	LRP1B	ENSG00000168702	0.061995358219888885	[218,170]	[143,272,291]	0	hSpCas9	negative selection	4999378
141015779	141015801	2	-	27760321	HT29	viability after 22 days	TGGCCAAACGGTTTAACTCTGG	LRP1B	ENSG00000168702	0.3044193472950338	[246,192]	[199,365,379]	3	hSpCas9	negative selection	4999379
140776142	140776164	2	+	27760321	HT29	viability after 19 days	GAAGTCTTATTCCGTAGGATGG	LRP1B	ENSG00000168702	0.6641639697183281	[97,76]	[169,13,287]	6	hSpCas9	negative selection	5082838
140883946	140883968	2	-	27760321	HT29	viability after 19 days	TGACAGTCGACTGGATAGCAGG	LRP1B	ENSG00000168702	-0.44652616926113003	[350,273]	[439,230,138]	-4	hSpCas9	negative selection	5082839
140903141	140903163	2	-	27760321	HT29	viability after 19 days	AGTGTTCGCTGAACAATGGAGG	LRP1B	ENSG00000168702	-0.1543878122145917	[380,297]	[201,663,171]	-1	hSpCas9	negative selection	5082840
141013695	141013717	2	+	27760321	HT29	viability after 19 days	ATGATGCGACAGTCCGAAAGGG	LRP1B	ENSG00000168702	-0.5985183041979144	[218,170]	[163,144,134]	-5	hSpCas9	negative selection	5082841
141015779	141015801	2	-	27760321	HT29	viability after 19 days	TGGCCAAACGGTTTAACTCTGG	LRP1B	ENSG00000168702	-0.009887805741542244	[246,192]	[298,213,241]	0	hSpCas9	negative selection	5082842
140776142	140776164	2	+	27760321	HT29	viability after 16 days	GAAGTCTTATTCCGTAGGATGG	LRP1B	ENSG00000168702	-0.18731867479807462	[97,76]	[101,67,89]	-2	hSpCas9	negative selection	5166301
140883946	140883968	2	-	27760321	HT29	viability after 16 days	TGACAGTCGACTGGATAGCAGG	LRP1B	ENSG00000168702	0.3457727693351932	[350,273]	[430,506,391]	4	hSpCas9	negative selection	5166302
140903141	140903163	2	-	27760321	HT29	viability after 16 days	AGTGTTCGCTGAACAATGGAGG	LRP1B	ENSG00000168702	-0.29928393953621535	[380,297]	[232,229,457]	-3	hSpCas9	negative selection	5166303
141013695	141013717	2	+	27760321	HT29	viability after 16 days	ATGATGCGACAGTCCGAAAGGG	LRP1B	ENSG00000168702	-0.35797806686073563	[218,170]	[42,194,259]	-4	hSpCas9	negative selection	5166304
141015779	141015801	2	-	27760321	HT29	viability after 16 days	TGGCCAAACGGTTTAACTCTGG	LRP1B	ENSG00000168702	-0.1104924187417502	[246,192]	[265,134,288]	-1	hSpCas9	negative selection	5166305
140776142	140776164	2	+	27760321	HT29	viability after 13 days	GAAGTCTTATTCCGTAGGATGG	LRP1B	ENSG00000168702	-0.9528569550947421	[97,76]	[13,65,75]	-7	hSpCas9	negative selection	5249764
140883946	140883968	2	-	27760321	HT29	viability after 13 days	TGACAGTCGACTGGATAGCAGG	LRP1B	ENSG00000168702	0.018018160110027742	[350,273]	[482,302,317]	0	hSpCas9	negative selection	5249765
140903141	140903163	2	-	27760321	HT29	viability after 13 days	AGTGTTCGCTGAACAATGGAGG	LRP1B	ENSG00000168702	-0.011750776772744179	[380,297]	[217,674,285]	0	hSpCas9	negative selection	5249766
141013695	141013717	2	+	27760321	HT29	viability after 13 days	ATGATGCGACAGTCCGAAAGGG	LRP1B	ENSG00000168702	-0.26419666826772736	[218,170]	[183,88,285]	-3	hSpCas9	negative selection	5249767
141015779	141015801	2	-	27760321	HT29	viability after 13 days	TGGCCAAACGGTTTAACTCTGG	LRP1B	ENSG00000168702	0.3525864108523327	[246,192]	[464,231,282]	4	hSpCas9	negative selection	5249768
140776142	140776164	2	+	27760321	HT29	viability after 10 days	GAAGTCTTATTCCGTAGGATGG	LRP1B	ENSG00000168702	-0.2742786830219641	[97,76]	[68,117,84]	-3	hSpCas9	negative selection	5333227
140883946	140883968	2	-	27760321	HT29	viability after 10 days	TGACAGTCGACTGGATAGCAGG	LRP1B	ENSG00000168702	0.38255063511778375	[350,273]	[479,563,483]	5	hSpCas9	negative selection	5333228
140903141	140903163	2	-	27760321	HT29	viability after 10 days	AGTGTTCGCTGAACAATGGAGG	LRP1B	ENSG00000168702	-0.4471209362333304	[380,297]	[150,485,300]	-5	hSpCas9	negative selection	5333229
141013695	141013717	2	+	27760321	HT29	viability after 10 days	ATGATGCGACAGTCCGAAAGGG	LRP1B	ENSG00000168702	0.214976814108791	[218,170]	[234,328,284]	3	hSpCas9	negative selection	5333230
141015779	141015801	2	-	27760321	HT29	viability after 10 days	TGGCCAAACGGTTTAACTCTGG	LRP1B	ENSG00000168702	0.3484556350994441	[246,192]	[440,264,340]	5	hSpCas9	negative selection	5333231
140776142	140776164	2	+	27760321	MOLM13	viability	GAAGTCTTATTCCGTAGGATGG	LRP1B	ENSG00000168702	-1.5092363391966381	[143,97]	[0,42]	-7	hSpCas9	negative selection	5416690
140883946	140883968	2	-	27760321	MOLM13	viability	TGACAGTCGACTGGATAGCAGG	LRP1B	ENSG00000168702	0.02619796608090516	[397,350]	[143,274]	0	hSpCas9	negative selection	5416691
140903141	140903163	2	-	27760321	MOLM13	viability	AGTGTTCGCTGAACAATGGAGG	LRP1B	ENSG00000168702	-0.12453094057065897	[449,380]	[223,205]	-1	hSpCas9	negative selection	5416692
141013695	141013717	2	+	27760321	MOLM13	viability	ATGATGCGACAGTCCGAAAGGG	LRP1B	ENSG00000168702	-1.6316285476045151	[261,218]	[68,21]	-7	hSpCas9	negative selection	5416693
141015779	141015801	2	-	27760321	MOLM13	viability	TGGCCAAACGGTTTAACTCTGG	LRP1B	ENSG00000168702	0.46339251614481836	[323,246]	[80,338]	3	hSpCas9	negative selection	5416694
142130703	142130726	2	+	27661255	K562	viability	GAGTAAGGCGAGGAGAAACTCGG	LRP1B	ENSG00000168702	0.03561226955825747	[1086,1119]	[983,833]	1	dCas9-KRAB	negative selection	5490879
142130725	142130748	2	+	27661255	K562	viability	GACATTGTGGTCGCCCGGTAAGG	LRP1B	ENSG00000168702	0.024511520824441413	[1276,1067]	[1040,882]	0	dCas9-KRAB	negative selection	5490880
142130812	142130835	2	+	27661255	K562	viability	GCTTGGAGCCTGGAATCGAGCGG	LRP1B	ENSG00000168702	-0.23303533711203955	[662,588]	[461,395]	-6	dCas9-KRAB	negative selection	5490881
142130920	142130943	2	+	27661255	K562	viability	GTGGAGGGATGCGCGCGTGCGGG	LRP1B	ENSG00000168702	0.07883983392330379	[525,528]	[478,415]	2	dCas9-KRAB	negative selection	5490882
142130930	142130953	2	+	27661255	K562	viability	GCGCGCGTGCGGGAGAGAGGAGG	LRP1B	ENSG00000168702	-0.7246567342088736	[361,498]	[241,176]	-8	dCas9-KRAB	negative selection	5490883
140951895	140951918	2	-	27260156	BXPC3	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.4548453131230641	[17]	[10,14,15,12]	-7	hSpCas9	negative selection	5553328
141810345	141810368	2	+	27260156	BXPC3	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.04511757838722008	[792]	[803,916,778,924]	1	hSpCas9	negative selection	5553329
140951859	140951882	2	-	27260156	BXPC3	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.1727912134719154	[341]	[377,415,427,387]	4	hSpCas9	negative selection	5553330
140833638	140833661	2	-	27260156	BXPC3	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.4883601507731874	[1116]	[1502,1463,1753,1877]	9	hSpCas9	negative selection	5584809
140704933	140704956	2	-	27260156	BXPC3	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.8917852460460765	[383]	[669,684,863,772]	9	hSpCas9	negative selection	5588125
140586627	140586650	2	+	27260156	BXPC3	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.17224175370082884	[242]	[169,261,368,367]	4	hSpCas9	negative selection	5589923
140586669	140586692	2	+	27260156	BXPC3	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.22248550593339506	[443]	[493,502,656,514]	5	hSpCas9	negative selection	5589924
140586623	140586646	2	-	27260156	BXPC3	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	0.15476423885319446	[766]	[704,810,959,1146]	3	hSpCas9	negative selection	5589925
140586672	140586695	2	-	27260156	BXPC3	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.5225895579067674	[929]	[1174,1503,1328,1612]	9	hSpCas9	negative selection	5589926
140982235	140982258	2	+	27260156	BXPC3	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.0173269304569853	[340]	[390,316,307,431]	0	hSpCas9	negative selection	5617587
141810287	141810310	2	+	27260156	BXPC3	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.10491892087433052	[250]	[325,181,306,317]	2	hSpCas9	negative selection	5617588
140982169	140982192	2	-	27260156	BXPC3	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.19733735558816068	[427]	[430,497,556,581]	4	hSpCas9	negative selection	5617589
140951895	140951918	2	-	27260156	A673	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.3188463470807248	[17]	[18,11,14,23]	-7	hSpCas9	negative selection	5674579
141810345	141810368	2	+	27260156	A673	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.07632050653971534	[792]	[951,878,869,916]	-2	hSpCas9	negative selection	5674580
140951859	140951882	2	-	27260156	A673	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.11501212721272402	[341]	[569,389,453,375]	2	hSpCas9	negative selection	5674581
140833638	140833661	2	-	27260156	A673	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.3473317139730021	[1116]	[1783,1696,1593,1759]	7	hSpCas9	negative selection	5706060
140704933	140704956	2	-	27260156	A673	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.7600724534489762	[383]	[872,686,777,797]	9	hSpCas9	negative selection	5709376
140586627	140586650	2	+	27260156	A673	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.40665391739290346	[242]	[400,441,319,383]	8	hSpCas9	negative selection	5711174
140586669	140586692	2	+	27260156	A673	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.12221597625036643	[443]	[618,587,500,618]	3	hSpCas9	negative selection	5711175
140586623	140586646	2	-	27260156	A673	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	0.0037991941694087705	[766]	[932,807,1042,909]	0	hSpCas9	negative selection	5711176
140586672	140586695	2	-	27260156	A673	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.47127211213967324	[929]	[1726,1464,1541,1473]	9	hSpCas9	negative selection	5711177
140982235	140982258	2	+	27260156	A673	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.07901766486147849	[340]	[443,307,345,464]	-2	hSpCas9	negative selection	5738838
141810287	141810310	2	+	27260156	A673	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.19225852131046317	[250]	[481,290,241,381]	4	hSpCas9	negative selection	5738839
140982169	140982192	2	-	27260156	A673	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.1643788104651213	[427]	[619,572,583,527]	4	hSpCas9	negative selection	5738840
140951895	140951918	2	-	27260156	A375	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-1.1903948540745768	[17]	[12,12,7,3]	-8	hSpCas9	negative selection	5795830
141810345	141810368	2	+	27260156	A375	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.08528064663572088	[792]	[1077,1349,674,886]	1	hSpCas9	negative selection	5795831
140951859	140951882	2	-	27260156	A375	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.22072039685141703	[341]	[529,588,396,372]	3	hSpCas9	negative selection	5795832
140833638	140833661	2	-	27260156	A375	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.7220281444509917	[1116]	[2183,2163,2419,1867]	9	hSpCas9	negative selection	5827311
140704933	140704956	2	-	27260156	A375	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.3215174200688575	[383]	[1560,1143,993,822]	9	hSpCas9	negative selection	5830627
140586627	140586650	2	+	27260156	A375	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.7006770147890347	[242]	[255,426,571,568]	9	hSpCas9	negative selection	5832425
140586669	140586692	2	+	27260156	A375	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.20663621556970585	[443]	[759,678,561,423]	3	hSpCas9	negative selection	5832426
140586623	140586646	2	-	27260156	A375	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.004567520925714885	[766]	[816,969,928,865]	0	hSpCas9	negative selection	5832427
140586672	140586695	2	-	27260156	A375	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.6746035736959983	[929]	[1861,2090,1670,1395]	8	hSpCas9	negative selection	5832428
140982235	140982258	2	+	27260156	A375	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.03949292884194594	[340]	[399,460,301,394]	0	hSpCas9	negative selection	5860089
141810287	141810310	2	+	27260156	A375	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.5151130238564379	[250]	[515,281,245,590]	7	hSpCas9	negative selection	5860090
140982169	140982192	2	-	27260156	A375	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.2039809978780036	[427]	[665,626,487,532]	3	hSpCas9	negative selection	5860091
140951895	140951918	2	-	27260156	COLO741	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	0.5959882324650883	[17]	[12,34,52]	9	hSpCas9	negative selection	5917081
141810345	141810368	2	+	27260156	COLO741	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.08956766738740396	[792]	[1049,962,856]	-2	hSpCas9	negative selection	5917082
140951859	140951882	2	-	27260156	COLO741	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	-0.0433720112767384	[341]	[487,413,377]	-1	hSpCas9	negative selection	5917083
140833638	140833661	2	-	27260156	COLO741	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.4399418618967381	[1116]	[1946,1757,2087]	8	hSpCas9	negative selection	5948562
140704933	140704956	2	-	27260156	COLO741	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.8047984249951786	[383]	[885,831,853]	9	hSpCas9	negative selection	5951878
140586627	140586650	2	+	27260156	COLO741	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.14576662942640972	[242]	[356,290,379]	3	hSpCas9	negative selection	5953676
140586669	140586692	2	+	27260156	COLO741	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.1466653091060238	[443]	[712,483,687]	3	hSpCas9	negative selection	5953677
140586623	140586646	2	-	27260156	COLO741	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	0.148182766356187	[766]	[1158,1383,744]	3	hSpCas9	negative selection	5953678
140586672	140586695	2	-	27260156	COLO741	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.4984695556372247	[929]	[2337,1462,1313]	8	hSpCas9	negative selection	5953679
140982235	140982258	2	+	27260156	COLO741	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.13414283181830317	[340]	[514,492,431]	3	hSpCas9	negative selection	5981340
141810287	141810310	2	+	27260156	COLO741	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.03659458659560111	[250]	[306,441,241]	0	hSpCas9	negative selection	5981341
140982169	140982192	2	-	27260156	COLO741	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	-0.01086630950264078	[427]	[497,535,585]	0	hSpCas9	negative selection	5981342
140951895	140951918	2	-	27260156	CAL120	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	0.768368973253907	[17]	[123,0,2]	9	hSpCas9	negative selection	6038332
141810345	141810368	2	+	27260156	CAL120	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.3757538680086484	[792]	[1304,1295,1243]	5	hSpCas9	negative selection	6038333
140951859	140951882	2	-	27260156	CAL120	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.10310431058974123	[341]	[504,508,365]	1	hSpCas9	negative selection	6038334
140833638	140833661	2	-	27260156	CAL120	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.5265017881907526	[1116]	[1963,2036,1998]	7	hSpCas9	negative selection	6069813
140704933	140704956	2	-	27260156	CAL120	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.6881345440799984	[383]	[802,664,844]	8	hSpCas9	negative selection	6073129
140586627	140586650	2	+	27260156	CAL120	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.08104102637575761	[242]	[191,360,385]	1	hSpCas9	negative selection	6074927
140586669	140586692	2	+	27260156	CAL120	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	-0.055256981783603554	[443]	[499,544,544]	-1	hSpCas9	negative selection	6074928
140586623	140586646	2	-	27260156	CAL120	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.2408365481574672	[766]	[1076,729,658]	-4	hSpCas9	negative selection	6074929
140586672	140586695	2	-	27260156	CAL120	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.8378744367033257	[929]	[2245,1499,2477]	9	hSpCas9	negative selection	6074930
140982235	140982258	2	+	27260156	CAL120	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.2361953563464258	[340]	[562,347,595]	3	hSpCas9	negative selection	6102591
141810287	141810310	2	+	27260156	CAL120	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.23531235260567218	[250]	[307,423,361]	3	hSpCas9	negative selection	6102592
140982169	140982192	2	-	27260156	CAL120	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.5854581731616355	[427]	[1008,913,510]	8	hSpCas9	negative selection	6102593
140951895	140951918	2	-	27260156	CADOES1	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.9692788573380264	[17]	[1,4,23,2]	-9	hSpCas9	negative selection	6159583
141810345	141810368	2	+	27260156	CADOES1	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.06149718665386461	[792]	[500,840,697,790]	-1	hSpCas9	negative selection	6159584
140951859	140951882	2	-	27260156	CADOES1	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	-0.05186282467920278	[341]	[363,297,289,273]	-1	hSpCas9	negative selection	6159585
140833638	140833661	2	-	27260156	CADOES1	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.54072367850921	[1116]	[1258,1671,1500,1617]	8	hSpCas9	negative selection	6191064
140704933	140704956	2	-	27260156	CADOES1	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.1133072281314311	[383]	[812,941,661,669]	9	hSpCas9	negative selection	6194380
140586627	140586650	2	+	27260156	CADOES1	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.37639311621153937	[242]	[332,196,328,314]	6	hSpCas9	negative selection	6196178
140586669	140586692	2	+	27260156	CADOES1	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.3605671881162812	[443]	[605,552,498,459]	6	hSpCas9	negative selection	6196179
140586623	140586646	2	-	27260156	CADOES1	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.09986405302604684	[766]	[713,345,801,804]	-2	hSpCas9	negative selection	6196180
140586672	140586695	2	-	27260156	CADOES1	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.5464897236408597	[929]	[1187,1296,1340,1225]	8	hSpCas9	negative selection	6196181
140982235	140982258	2	+	27260156	CADOES1	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.173195526725075	[340]	[433,264,373,356]	3	hSpCas9	negative selection	6223842
141810287	141810310	2	+	27260156	CADOES1	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.7188071569339679	[250]	[414,319,432,367]	9	hSpCas9	negative selection	6223843
140982169	140982192	2	-	27260156	CADOES1	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	-0.11336717597830606	[427]	[254,365,436,415]	-2	hSpCas9	negative selection	6223844
140951895	140951918	2	-	27260156	EWS502	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.31289023883790446	[17]	[23,23,6,3]	-5	hSpCas9	negative selection	6280834
141810345	141810368	2	+	27260156	EWS502	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.2842592972186079	[792]	[544,691,798,742]	-5	hSpCas9	negative selection	6280835
140951859	140951882	2	-	27260156	EWS502	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.20371809051741208	[341]	[335,482,398,458]	3	hSpCas9	negative selection	6280836
140833638	140833661	2	-	27260156	EWS502	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.4631283376734252	[1116]	[1600,1313,1703,1937]	7	hSpCas9	negative selection	6312315
140704933	140704956	2	-	27260156	EWS502	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.9830546361508551	[383]	[815,745,770,885]	9	hSpCas9	negative selection	6315631
140586627	140586650	2	+	27260156	EWS502	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.34958806751384297	[242]	[267,474,216,351]	6	hSpCas9	negative selection	6317429
140586669	140586692	2	+	27260156	EWS502	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.17426274543509063	[443]	[621,479,506,499]	3	hSpCas9	negative selection	6317430
140586623	140586646	2	-	27260156	EWS502	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.03494994427833131	[766]	[737,834,885,709]	0	hSpCas9	negative selection	6317431
140586672	140586695	2	-	27260156	EWS502	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.28388757369802753	[929]	[1005,1260,1354,1192]	5	hSpCas9	negative selection	6317432
140982235	140982258	2	+	27260156	EWS502	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.18730225658311445	[340]	[261,311,358,343]	-3	hSpCas9	negative selection	6345093
141810287	141810310	2	+	27260156	EWS502	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.24044482462768413	[250]	[394,229,302,320]	4	hSpCas9	negative selection	6345094
140982169	140982192	2	-	27260156	EWS502	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	-0.27123185114866266	[427]	[310,402,376,419]	-5	hSpCas9	negative selection	6345095
140951895	140951918	2	-	27260156	EW8	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.1050378822571334	[17]	[0,27,18,3]	-2	hSpCas9	negative selection	6402085
141810345	141810368	2	+	27260156	EW8	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.07100953466324611	[792]	[519,591,778,515]	-1	hSpCas9	negative selection	6402086
140951859	140951882	2	-	27260156	EW8	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	-0.014310595239219126	[341]	[388,242,259,219]	0	hSpCas9	negative selection	6402087
140833638	140833661	2	-	27260156	EW8	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.4248259630548086	[1116]	[1464,1305,951,1206]	7	hSpCas9	negative selection	6433566
140704933	140704956	2	-	27260156	EW8	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.1111416607445403	[383]	[648,811,530,716]	9	hSpCas9	negative selection	6436882
140586627	140586650	2	+	27260156	EW8	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	-0.04132556343591798	[242]	[236,130,116,296]	-1	hSpCas9	negative selection	6438680
140586669	140586692	2	+	27260156	EW8	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	-0.03339674906416662	[443]	[385,288,355,376]	0	hSpCas9	negative selection	6438681
140586623	140586646	2	-	27260156	EW8	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	0.13256109564708451	[766]	[619,860,675,561]	2	hSpCas9	negative selection	6438682
140586672	140586695	2	-	27260156	EW8	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.562879725114751	[929]	[1169,1010,937,1365]	8	hSpCas9	negative selection	6438683
140982235	140982258	2	+	27260156	EW8	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.09810354594865744	[340]	[235,376,218,356]	1	hSpCas9	negative selection	6466344
141810287	141810310	2	+	27260156	EW8	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.37825144786323794	[250]	[314,276,207,271]	7	hSpCas9	negative selection	6466345
140982169	140982192	2	-	27260156	EW8	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	-0.045932928695865016	[427]	[420,391,275,273]	-1	hSpCas9	negative selection	6466346
140951895	140951918	2	-	27260156	CORL105	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.9187888327983913	[17]	[3,31,4,1]	-9	hSpCas9	negative selection	6523336
141810345	141810368	2	+	27260156	CORL105	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.011171954618706348	[792]	[942,917,1119,790]	0	hSpCas9	negative selection	6523337
140951859	140951882	2	-	27260156	CORL105	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.33239652552560606	[341]	[566,515,550,391]	6	hSpCas9	negative selection	6523338
140833638	140833661	2	-	27260156	CORL105	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.5790534408190009	[1116]	[2142,1771,2526,1472]	9	hSpCas9	negative selection	6554817
140704933	140704956	2	-	27260156	CORL105	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.9964168821783872	[383]	[902,797,978,921]	9	hSpCas9	negative selection	6558133
140586627	140586650	2	+	27260156	CORL105	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.7804076711659804	[242]	[467,416,415,641]	9	hSpCas9	negative selection	6559931
140586669	140586692	2	+	27260156	CORL105	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.5009249288600364	[443]	[707,841,733,654]	8	hSpCas9	negative selection	6559932
140586623	140586646	2	-	27260156	CORL105	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.08541292939264467	[766]	[735,718,1104,863]	-1	hSpCas9	negative selection	6559933
140586672	140586695	2	-	27260156	CORL105	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.6586250447207398	[929]	[1738,1714,1875,1569]	9	hSpCas9	negative selection	6559934
140982235	140982258	2	+	27260156	CORL105	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.11516549058625936	[340]	[412,301,640,407]	2	hSpCas9	negative selection	6587595
141810287	141810310	2	+	27260156	CORL105	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.2859127074245593	[250]	[397,245,444,360]	5	hSpCas9	negative selection	6587596
140982169	140982192	2	-	27260156	CORL105	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.20200708649252436	[427]	[429,556,626,693]	4	hSpCas9	negative selection	6587597
140951895	140951918	2	-	27260156	HS294T	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.22581839500868917	[17]	[8,0,5,7]	-3	hSpCas9	negative selection	6644587
141810345	141810368	2	+	27260156	HS294T	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.1017854707427257	[792]	[225,352,237,336]	-1	hSpCas9	negative selection	6644588
140951859	140951882	2	-	27260156	HS294T	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	-0.3431965691191765	[341]	[93,81,109,137]	-5	hSpCas9	negative selection	6644589
140833638	140833661	2	-	27260156	HS294T	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.6618312227106697	[1116]	[442,815,605,924]	8	hSpCas9	negative selection	6676068
140704933	140704956	2	-	27260156	HS294T	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.7819173755968434	[383]	[240,326,221,223]	8	hSpCas9	negative selection	6679384
140586627	140586650	2	+	27260156	HS294T	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.27893777441633416	[242]	[62,96,87,232]	4	hSpCas9	negative selection	6681182
140586669	140586692	2	+	27260156	HS294T	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.5167513878185888	[443]	[231,178,204,393]	7	hSpCas9	negative selection	6681183
140586623	140586646	2	-	27260156	HS294T	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	0.18362739393273086	[766]	[368,288,372,308]	2	hSpCas9	negative selection	6681184
140586672	140586695	2	-	27260156	HS294T	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.5393332039283043	[929]	[442,582,451,634]	7	hSpCas9	negative selection	6681185
140982235	140982258	2	+	27260156	HS294T	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.028851119875988374	[340]	[82,181,105,151]	0	hSpCas9	negative selection	6708846
141810287	141810310	2	+	27260156	HS294T	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.3890449763751198	[250]	[95,110,104,213]	5	hSpCas9	negative selection	6708847
140982169	140982192	2	-	27260156	HS294T	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.30037405989923727	[427]	[153,170,203,308]	4	hSpCas9	negative selection	6708848
140951895	140951918	2	-	27260156	HCC44	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.2929951746722397	[17]	[30,0,12,23]	-5	hSpCas9	negative selection	6765838
141810345	141810368	2	+	27260156	HCC44	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.02992275348887763	[792]	[1013,826,1042,817]	0	hSpCas9	negative selection	6765839
140951859	140951882	2	-	27260156	HCC44	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	-0.019286820840396957	[341]	[325,543,337,282]	0	hSpCas9	negative selection	6765840
140833638	140833661	2	-	27260156	HCC44	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.6853676068088359	[1116]	[2047,1584,2416,2185]	9	hSpCas9	negative selection	6797319
140704933	140704956	2	-	27260156	HCC44	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.115269974218005	[383]	[1275,707,1276,626]	9	hSpCas9	negative selection	6800635
140586627	140586650	2	+	27260156	HCC44	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.023537479124237648	[242]	[399,171,323,253]	0	hSpCas9	negative selection	6802433
140586669	140586692	2	+	27260156	HCC44	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	-0.06227464966937987	[443]	[502,318,682,474]	-1	hSpCas9	negative selection	6802434
140586623	140586646	2	-	27260156	HCC44	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	0.021987046604477256	[766]	[800,501,1138,1155]	0	hSpCas9	negative selection	6802435
140586672	140586695	2	-	27260156	HCC44	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.573091976829043	[929]	[1584,1222,1733,1776]	8	hSpCas9	negative selection	6802436
140982235	140982258	2	+	27260156	HCC44	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.12910974893839428	[340]	[298,280,588,286]	-2	hSpCas9	negative selection	6830097
141810287	141810310	2	+	27260156	HCC44	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.5461964457127404	[250]	[537,351,447,344]	8	hSpCas9	negative selection	6830098
140982169	140982192	2	-	27260156	HCC44	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.05916153492189598	[427]	[526,382,775,396]	0	hSpCas9	negative selection	6830099
140951895	140951918	2	-	27260156	G402	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.546879650651384	[17]	[24,31,0,4]	-6	hSpCas9	negative selection	6887089
141810345	141810368	2	+	27260156	G402	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.30683299776017814	[792]	[1354,1212,1023,1213]	4	hSpCas9	negative selection	6887090
140951859	140951882	2	-	27260156	G402	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.22461109178695512	[341]	[364,825,345,416]	3	hSpCas9	negative selection	6887091
140833638	140833661	2	-	27260156	G402	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.7267752589794951	[1116]	[2498,3022,2047,1557]	8	hSpCas9	negative selection	6918570
140704933	140704956	2	-	27260156	G402	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.6857243425463642	[383]	[1349,1663,1192,1788]	9	hSpCas9	negative selection	6921886
140586627	140586650	2	+	27260156	G402	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.7764350918992657	[242]	[213,840,644,315]	8	hSpCas9	negative selection	6923684
140586669	140586692	2	+	27260156	G402	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	-0.0332507898402955	[443]	[485,443,487,678]	0	hSpCas9	negative selection	6923685
140586623	140586646	2	-	27260156	G402	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.1991656412355639	[766]	[1018,1170,645,487]	-3	hSpCas9	negative selection	6923686
140586672	140586695	2	-	27260156	G402	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.3962763075377198	[929]	[1699,1305,1802,1192]	5	hSpCas9	negative selection	6923687
140982235	140982258	2	+	27260156	G402	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.13607093220665495	[340]	[743,330,174,603]	1	hSpCas9	negative selection	6951348
141810287	141810310	2	+	27260156	G402	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.5300614212837318	[250]	[513,386,209,652]	6	hSpCas9	negative selection	6951349
140982169	140982192	2	-	27260156	G402	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.3152543768577268	[427]	[590,390,853,732]	4	hSpCas9	negative selection	6951350
140951895	140951918	2	-	27260156	L33	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	0.3195602255473107	[17]	[21,5,11,33]	6	hSpCas9	negative selection	7008340
141810345	141810368	2	+	27260156	L33	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.1793001144171137	[792]	[788,212,392,862]	-4	hSpCas9	negative selection	7008341
140951859	140951882	2	-	27260156	L33	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	-0.00518031869040253	[341]	[240,137,224,428]	0	hSpCas9	negative selection	7008342
140833638	140833661	2	-	27260156	L33	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.19011131384664504	[1116]	[1222,462,774,1509]	4	hSpCas9	negative selection	7039821
140704933	140704956	2	-	27260156	L33	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.954592024289603	[383]	[759,335,410,741]	9	hSpCas9	negative selection	7043137
140586627	140586650	2	+	27260156	L33	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.2162887807416204	[242]	[304,109,207,224]	5	hSpCas9	negative selection	7044935
140586669	140586692	2	+	27260156	L33	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.32376153392831974	[443]	[465,200,409,615]	7	hSpCas9	negative selection	7044936
140586623	140586646	2	-	27260156	L33	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.10339090811116891	[766]	[887,262,378,717]	-2	hSpCas9	negative selection	7044937
140586672	140586695	2	-	27260156	L33	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.6942897057447692	[929]	[1312,613,1067,1513]	9	hSpCas9	negative selection	7044938
140982235	140982258	2	+	27260156	L33	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.14213889679153452	[340]	[328,150,172,262]	-3	hSpCas9	negative selection	7072599
141810287	141810310	2	+	27260156	L33	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.371224291983545	[250]	[344,84,198,427]	7	hSpCas9	negative selection	7072600
140982169	140982192	2	-	27260156	L33	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	-0.14854632165720077	[427]	[320,158,312,339]	-3	hSpCas9	negative selection	7072601
140951895	140951918	2	-	27260156	K562	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	0.7373356831827942	[17]	[43,2,17,39]	8	hSpCas9	negative selection	7129591
141810345	141810368	2	+	27260156	K562	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.14606880494908125	[792]	[820,709,598,451]	-2	hSpCas9	negative selection	7129592
140951859	140951882	2	-	27260156	K562	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.09325740458509718	[341]	[274,373,174,452]	1	hSpCas9	negative selection	7129593
140833638	140833661	2	-	27260156	K562	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.4778959032818497	[1116]	[965,1625,1718,1204]	6	hSpCas9	negative selection	7161072
140704933	140704956	2	-	27260156	K562	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.0830959946621679	[383]	[740,520,667,921]	9	hSpCas9	negative selection	7164388
140586627	140586650	2	+	27260156	K562	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.19845220264551744	[242]	[88,265,357,261]	2	hSpCas9	negative selection	7166186
140586669	140586692	2	+	27260156	K562	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.027332608337979347	[443]	[573,417,211,413]	0	hSpCas9	negative selection	7166187
140586623	140586646	2	-	27260156	K562	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	0.1504460790676435	[766]	[1045,993,457,577]	1	hSpCas9	negative selection	7166188
140586672	140586695	2	-	27260156	K562	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.6133298359596944	[929]	[1147,1901,1265,806]	7	hSpCas9	negative selection	7166189
140982235	140982258	2	+	27260156	K562	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.09244089719553977	[340]	[444,356,195,166]	-1	hSpCas9	negative selection	7193850
141810287	141810310	2	+	27260156	K562	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.9431102707846715	[250]	[140,1018,415,172]	9	hSpCas9	negative selection	7193851
140982169	140982192	2	-	27260156	K562	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.3684122329618669	[427]	[328,684,449,491]	4	hSpCas9	negative selection	7193852
140951895	140951918	2	-	27260156	HT29	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	0.4450268495781238	[17]	[58,11,21,26]	8	hSpCas9	negative selection	7250842
141810345	141810368	2	+	27260156	HT29	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.19960143215317672	[792]	[769,728,847,972]	-4	hSpCas9	negative selection	7250843
140951859	140951882	2	-	27260156	HT29	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.12720373501278354	[341]	[577,464,304,472]	2	hSpCas9	negative selection	7250844
140833638	140833661	2	-	27260156	HT29	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.5359441929816875	[1116]	[2143,2493,1984,1370]	9	hSpCas9	negative selection	7282323
140704933	140704956	2	-	27260156	HT29	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.9450630216691609	[383]	[1060,898,824,824]	9	hSpCas9	negative selection	7285639
140586627	140586650	2	+	27260156	HT29	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.5770267996705736	[242]	[429,453,544,342]	9	hSpCas9	negative selection	7287437
140586669	140586692	2	+	27260156	HT29	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.2279110188683626	[443]	[671,788,587,506]	4	hSpCas9	negative selection	7287438
140586623	140586646	2	-	27260156	HT29	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.0296436760334865	[766]	[963,939,977,786]	0	hSpCas9	negative selection	7287439
140586672	140586695	2	-	27260156	HT29	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.6788648605073657	[929]	[1806,1954,1878,1620]	9	hSpCas9	negative selection	7287440
140982235	140982258	2	+	27260156	HT29	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.09651188259116844	[340]	[632,432,450,285]	1	hSpCas9	negative selection	7315101
141810287	141810310	2	+	27260156	HT29	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.0627573146414584	[250]	[322,426,239,294]	1	hSpCas9	negative selection	7315102
140982169	140982192	2	-	27260156	HT29	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.2749789812550586	[427]	[700,790,600,460]	5	hSpCas9	negative selection	7315103
140951895	140951918	2	-	27260156	MHHES1	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.8329442099981659	[17]	[9,14,21,0]	-9	hSpCas9	negative selection	7372093
141810345	141810368	2	+	27260156	MHHES1	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.12360562740683945	[792]	[1044,829,830,627]	-2	hSpCas9	negative selection	7372094
140951859	140951882	2	-	27260156	MHHES1	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	-0.31005429263004636	[341]	[384,364,222,282]	-5	hSpCas9	negative selection	7372095
140833638	140833661	2	-	27260156	MHHES1	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.5161426703820873	[1116]	[2244,2243,1298,1526]	8	hSpCas9	negative selection	7403574
140704933	140704956	2	-	27260156	MHHES1	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.2372819526878178	[383]	[1216,1144,1217,609]	9	hSpCas9	negative selection	7406890
140586627	140586650	2	+	27260156	MHHES1	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.1285156773136329	[242]	[384,388,189,254]	2	hSpCas9	negative selection	7408688
140586669	140586692	2	+	27260156	MHHES1	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.05947052671118456	[443]	[695,373,485,521]	1	hSpCas9	negative selection	7408689
140586623	140586646	2	-	27260156	MHHES1	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	0.1909738082537734	[766]	[1143,1025,1028,791]	3	hSpCas9	negative selection	7408690
140586672	140586695	2	-	27260156	MHHES1	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.5659398017886608	[929]	[1917,1718,1622,1079]	8	hSpCas9	negative selection	7408691
140982235	140982258	2	+	27260156	MHHES1	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.06268504255966767	[340]	[424,350,410,404]	1	hSpCas9	negative selection	7436352
141810287	141810310	2	+	27260156	MHHES1	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.4356751199034633	[250]	[760,322,312,204]	7	hSpCas9	negative selection	7436353
140982169	140982192	2	-	27260156	MHHES1	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	-0.3356505824740044	[427]	[481,316,422,317]	-6	hSpCas9	negative selection	7436354
140951895	140951918	2	-	27260156	MEWO	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.2950519699785774	[17]	[17,13,9]	-6	hSpCas9	negative selection	7493344
141810345	141810368	2	+	27260156	MEWO	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.20399351382347208	[792]	[776,610,569]	-4	hSpCas9	negative selection	7493345
140951859	140951882	2	-	27260156	MEWO	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	-0.12422919389880727	[341]	[300,306,273]	-3	hSpCas9	negative selection	7493346
140833638	140833661	2	-	27260156	MEWO	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.42704352758777575	[1116]	[1732,1251,1293]	8	hSpCas9	negative selection	7524825
140704933	140704956	2	-	27260156	MEWO	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.8608802600403339	[383]	[735,533,703]	9	hSpCas9	negative selection	7528141
140586627	140586650	2	+	27260156	MEWO	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.3500220513786465	[242]	[262,298,301]	7	hSpCas9	negative selection	7529939
140586669	140586692	2	+	27260156	MEWO	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.14195416948711456	[443]	[616,387,400]	3	hSpCas9	negative selection	7529940
140586623	140586646	2	-	27260156	MEWO	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	0.009228338228782551	[766]	[859,533,799]	0	hSpCas9	negative selection	7529941
140586672	140586695	2	-	27260156	MEWO	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.35222621506026597	[929]	[1123,977,1232]	7	hSpCas9	negative selection	7529942
140982235	140982258	2	+	27260156	MEWO	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.04440050090530884	[340]	[287,281,353]	-1	hSpCas9	negative selection	7557603
141810287	141810310	2	+	27260156	MEWO	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	-0.0009705990187894864	[250]	[227,164,309]	0	hSpCas9	negative selection	7557604
140982169	140982192	2	-	27260156	MEWO	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.2500673593216397	[427]	[533,415,489]	5	hSpCas9	negative selection	7557605
140951895	140951918	2	-	27260156	LNCAPCLONEFGC	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	0.08092346767967484	[17]	[23,25,1,13]	1	hSpCas9	negative selection	7614595
141810345	141810368	2	+	27260156	LNCAPCLONEFGC	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.21196817800541345	[792]	[876,785,880,792]	3	hSpCas9	negative selection	7614596
140951859	140951882	2	-	27260156	LNCAPCLONEFGC	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.29198948224828214	[341]	[415,248,440,427]	4	hSpCas9	negative selection	7614597
140833638	140833661	2	-	27260156	LNCAPCLONEFGC	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.6815796939007026	[1116]	[1666,1607,1699,1526]	9	hSpCas9	negative selection	7646076
140704933	140704956	2	-	27260156	LNCAPCLONEFGC	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.10722744592342	[383]	[693,692,770,846]	9	hSpCas9	negative selection	7649392
140586627	140586650	2	+	27260156	LNCAPCLONEFGC	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.29100914508694564	[242]	[160,414,278,215]	4	hSpCas9	negative selection	7651190
140586669	140586692	2	+	27260156	LNCAPCLONEFGC	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.14919741238828085	[443]	[440,418,481,448]	2	hSpCas9	negative selection	7651191
140586623	140586646	2	-	27260156	LNCAPCLONEFGC	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	0.16682656071603785	[766]	[721,499,1224,757]	2	hSpCas9	negative selection	7651192
140586672	140586695	2	-	27260156	LNCAPCLONEFGC	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.6547894195517878	[929]	[1119,1183,1825,1261]	9	hSpCas9	negative selection	7651193
140982235	140982258	2	+	27260156	LNCAPCLONEFGC	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.34818300578464206	[340]	[364,349,426,438]	5	hSpCas9	negative selection	7678854
141810287	141810310	2	+	27260156	LNCAPCLONEFGC	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.2750057653014293	[250]	[224,223,317,343]	4	hSpCas9	negative selection	7678855
140982169	140982192	2	-	27260156	LNCAPCLONEFGC	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	-0.148213583737838	[427]	[332,352,266,433]	-2	hSpCas9	negative selection	7678856
140951895	140951918	2	-	27260156	PANC0327	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.1330960731456683	[17]	[2,32,15,2]	-2	hSpCas9	negative selection	7735846
141810345	141810368	2	+	27260156	PANC0327	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.12856714923880275	[792]	[1014,472,992,657]	1	hSpCas9	negative selection	7735847
140951859	140951882	2	-	27260156	PANC0327	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	-0.047859567461869146	[341]	[292,396,226,244]	0	hSpCas9	negative selection	7735848
140833638	140833661	2	-	27260156	PANC0327	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.6813786893541498	[1116]	[1346,1386,1817,1818]	8	hSpCas9	negative selection	7767327
140704933	140704956	2	-	27260156	PANC0327	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.7941376206936773	[383]	[452,482,886,545]	9	hSpCas9	negative selection	7770643
140586627	140586650	2	+	27260156	PANC0327	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.4942922176951753	[242]	[190,296,415,303]	7	hSpCas9	negative selection	7772441
140586669	140586692	2	+	27260156	PANC0327	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	-0.1536658247067435	[443]	[337,359,327,389]	-2	hSpCas9	negative selection	7772442
140586623	140586646	2	-	27260156	PANC0327	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	0.4872929173452034	[766]	[790,971,1214,826]	7	hSpCas9	negative selection	7772443
140586672	140586695	2	-	27260156	PANC0327	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.6375452008041393	[929]	[1206,1299,1282,1341]	8	hSpCas9	negative selection	7772444
140982235	140982258	2	+	27260156	PANC0327	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.2734808065611329	[340]	[515,332,335,295]	4	hSpCas9	negative selection	7800105
141810287	141810310	2	+	27260156	PANC0327	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.3166495781622022	[250]	[232,252,214,408]	5	hSpCas9	negative selection	7800106
140982169	140982192	2	-	27260156	PANC0327	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.16809995841632247	[427]	[510,467,310,419]	2	hSpCas9	negative selection	7800107
140951895	140951918	2	-	27260156	NCIH2009	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.4887158047544613	[17]	[4,27,17]	-6	hSpCas9	negative selection	7857097
141810345	141810368	2	+	27260156	NCIH2009	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.2597974150952111	[792]	[1185,871,768]	-4	hSpCas9	negative selection	7857098
140951859	140951882	2	-	27260156	NCIH2009	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	-0.04053326741289853	[341]	[526,481,395]	0	hSpCas9	negative selection	7857099
140833638	140833661	2	-	27260156	NCIH2009	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.6935261782507942	[1116]	[2874,2456,2305]	8	hSpCas9	negative selection	7888578
140704933	140704956	2	-	27260156	NCIH2009	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.3121423192282387	[383]	[1546,1045,1448]	9	hSpCas9	negative selection	7891894
140586627	140586650	2	+	27260156	NCIH2009	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.5148836044797949	[242]	[724,481,294]	7	hSpCas9	negative selection	7893692
140586669	140586692	2	+	27260156	NCIH2009	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.3247066519684788	[443]	[943,746,671]	4	hSpCas9	negative selection	7893693
140586623	140586646	2	-	27260156	NCIH2009	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.3368507853041285	[766]	[1018,720,839]	-4	hSpCas9	negative selection	7893694
140586672	140586695	2	-	27260156	NCIH2009	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.6261802003191421	[929]	[2343,1512,2231]	8	hSpCas9	negative selection	7893695
140982235	140982258	2	+	27260156	NCIH2009	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.18538880997530688	[340]	[507,353,412]	-3	hSpCas9	negative selection	7921356
141810287	141810310	2	+	27260156	NCIH2009	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	1.6942821340040757	[250]	[471,400,2411]	9	hSpCas9	negative selection	7921357
140982169	140982192	2	-	27260156	NCIH2009	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	-0.8457411296477659	[427]	[436,290,290]	-7	hSpCas9	negative selection	7921358
140951895	140951918	2	-	27260156	NCIH1373	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-1.1716811452603215	[17]	[1,12,0,4]	-8	hSpCas9	negative selection	7978348
141810345	141810368	2	+	27260156	NCIH1373	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.4114266101396608	[792]	[819,631,391,228]	-4	hSpCas9	negative selection	7978349
140951859	140951882	2	-	27260156	NCIH1373	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.019409060895611674	[341]	[467,488,106,131]	0	hSpCas9	negative selection	7978350
140833638	140833661	2	-	27260156	NCIH1373	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	1.016801383691336	[1116]	[2915,2225,2518,670]	9	hSpCas9	negative selection	8009829
140704933	140704956	2	-	27260156	NCIH1373	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.5220585212136277	[383]	[1507,1183,1137,302]	9	hSpCas9	negative selection	8013145
140586627	140586650	2	+	27260156	NCIH1373	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.9298608342588894	[242]	[1118,488,284,69]	8	hSpCas9	negative selection	8014943
140586669	140586692	2	+	27260156	NCIH1373	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.29336499662175647	[443]	[561,464,597,218]	3	hSpCas9	negative selection	8014944
140586623	140586646	2	-	27260156	NCIH1373	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.6414295128822745	[766]	[988,480,457,88]	-6	hSpCas9	negative selection	8014945
140586672	140586695	2	-	27260156	NCIH1373	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.7124334071911875	[929]	[2224,1235,1895,416]	7	hSpCas9	negative selection	8014946
140982235	140982258	2	+	27260156	NCIH1373	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.8954233306811803	[340]	[834,688,844,124]	8	hSpCas9	negative selection	8042607
141810287	141810310	2	+	27260156	NCIH1373	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.6898856245930328	[250]	[625,452,415,88]	7	hSpCas9	negative selection	8042608
140982169	140982192	2	-	27260156	NCIH1373	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.17000502827393243	[427]	[982,408,437,105]	1	hSpCas9	negative selection	8042609
140951895	140951918	2	-	27260156	PATU8902	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-4.645002217303933	[17]	[0,0,0,0]	-9	hSpCas9	negative selection	8099599
141810345	141810368	2	+	27260156	PATU8902	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.007258924661096233	[792]	[1212,1110,970,1178]	0	hSpCas9	negative selection	8099600
140951859	140951882	2	-	27260156	PATU8902	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.4549911355023859	[341]	[397,1100,888,94]	5	hSpCas9	negative selection	8099601
140833638	140833661	2	-	27260156	PATU8902	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	1.2176656900919567	[1116]	[3486,3622,2682,5067]	9	hSpCas9	negative selection	8131080
140704933	140704956	2	-	27260156	PATU8902	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.608069343768062	[383]	[1744,1810,1569,1364]	9	hSpCas9	negative selection	8134396
140586627	140586650	2	+	27260156	PATU8902	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	1.3375156441896623	[242]	[1159,575,1163,370]	9	hSpCas9	negative selection	8136194
140586669	140586692	2	+	27260156	PATU8902	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.32823457099011655	[443]	[625,1049,501,1024]	3	hSpCas9	negative selection	8136195
140586623	140586646	2	-	27260156	PATU8902	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.10809212013450276	[766]	[1433,450,1129,884]	-1	hSpCas9	negative selection	8136196
140586672	140586695	2	-	27260156	PATU8902	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.6433070251072657	[929]	[2182,2050,1650,2320]	6	hSpCas9	negative selection	8136197
140982235	140982258	2	+	27260156	PATU8902	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.3264160031636737	[340]	[627,565,642,517]	3	hSpCas9	negative selection	8163858
141810287	141810310	2	+	27260156	PATU8902	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.3857044074776198	[250]	[369,321,355,848]	4	hSpCas9	negative selection	8163859
140982169	140982192	2	-	27260156	PATU8902	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.147594622088173	[427]	[482,935,681,514]	1	hSpCas9	negative selection	8163860
140951895	140951918	2	-	27260156	PANC1	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.6107517599373349	[17]	[12,1,15,7]	-7	hSpCas9	negative selection	8220850
141810345	141810368	2	+	27260156	PANC1	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.13143314185955524	[792]	[535,727,664,578]	-2	hSpCas9	negative selection	8220851
140951859	140951882	2	-	27260156	PANC1	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.3791349358029608	[341]	[354,672,306,265]	6	hSpCas9	negative selection	8220852
140833638	140833661	2	-	27260156	PANC1	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.5731460465820302	[1116]	[1555,1712,1510,1028]	8	hSpCas9	negative selection	8252331
140704933	140704956	2	-	27260156	PANC1	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.166394347113895	[383]	[765,846,734,638]	9	hSpCas9	negative selection	8255647
140586627	140586650	2	+	27260156	PANC1	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.20033772836999808	[242]	[142,247,257,299]	3	hSpCas9	negative selection	8257445
140586669	140586692	2	+	27260156	PANC1	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.32989449584241837	[443]	[519,709,496,264]	5	hSpCas9	negative selection	8257446
140586623	140586646	2	-	27260156	PANC1	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.16262043387298442	[766]	[682,514,647,496]	-3	hSpCas9	negative selection	8257447
140586672	140586695	2	-	27260156	PANC1	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.6067020906949725	[929]	[1176,1527,973,1226]	8	hSpCas9	negative selection	8257448
140982235	140982258	2	+	27260156	PANC1	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.22470563400472005	[340]	[188,562,404,267]	3	hSpCas9	negative selection	8285109
141810287	141810310	2	+	27260156	PANC1	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.5521139642417305	[250]	[340,339,331,259]	8	hSpCas9	negative selection	8285110
140982169	140982192	2	-	27260156	PANC1	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	-0.0021210405846449343	[427]	[466,411,314,287]	0	hSpCas9	negative selection	8285111
140951895	140951918	2	-	27260156	PANC0813	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-1.421750321316635	[17]	[13,0,6,9]	-9	hSpCas9	negative selection	8342101
141810345	141810368	2	+	27260156	PANC0813	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.1970430910687745	[792]	[1103,1329,988,860]	3	hSpCas9	negative selection	8342102
140951859	140951882	2	-	27260156	PANC0813	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	-0.1238944745423961	[341]	[344,380,498,253]	-2	hSpCas9	negative selection	8342103
140833638	140833661	2	-	27260156	PANC0813	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.6185148609868849	[1116]	[2265,2162,1586,2056]	8	hSpCas9	negative selection	8373582
140704933	140704956	2	-	27260156	PANC0813	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.1233390889186188	[383]	[1056,1202,772,905]	9	hSpCas9	negative selection	8376898
140586627	140586650	2	+	27260156	PANC0813	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.42688444879233567	[242]	[572,220,325,428]	7	hSpCas9	negative selection	8378696
140586669	140586692	2	+	27260156	PANC0813	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.4732346833978122	[443]	[791,682,786,643]	7	hSpCas9	negative selection	8378697
140586623	140586646	2	-	27260156	PANC0813	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.01572264740931062	[766]	[1005,941,663,956]	0	hSpCas9	negative selection	8378698
140586672	140586695	2	-	27260156	PANC0813	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.7249891465117888	[929]	[1791,1660,1940,1823]	9	hSpCas9	negative selection	8378699
140982235	140982258	2	+	27260156	PANC0813	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.06018983597840449	[340]	[488,292,313,445]	-1	hSpCas9	negative selection	8406360
141810287	141810310	2	+	27260156	PANC0813	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.6704450131478529	[250]	[363,457,609,436]	9	hSpCas9	negative selection	8406361
140982169	140982192	2	-	27260156	PANC0813	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	-0.4687013878705511	[427]	[336,371,425,317]	-6	hSpCas9	negative selection	8406362
140951895	140951918	2	-	27260156	RDES	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.4164883630621903	[17]	[33,7,8,4]	-6	hSpCas9	negative selection	8463352
141810345	141810368	2	+	27260156	RDES	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.17068643782832538	[792]	[682,667,790,1169]	-3	hSpCas9	negative selection	8463353
140951859	140951882	2	-	27260156	RDES	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	-0.2601908044606611	[341]	[222,462,276,351]	-4	hSpCas9	negative selection	8463354
140833638	140833661	2	-	27260156	RDES	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.6070198872722179	[1116]	[1619,1919,1898,2480]	8	hSpCas9	negative selection	8494833
140704933	140704956	2	-	27260156	RDES	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.2191525537797943	[383]	[822,756,1138,1512]	9	hSpCas9	negative selection	8498149
140586627	140586650	2	+	27260156	RDES	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.4248692829529669	[242]	[297,321,447,458]	6	hSpCas9	negative selection	8499947
140586669	140586692	2	+	27260156	RDES	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	-0.07479454415249087	[443]	[400,369,629,571]	-1	hSpCas9	negative selection	8499948
140586623	140586646	2	-	27260156	RDES	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.15080387366278258	[766]	[668,769,821,945]	-3	hSpCas9	negative selection	8499949
140586672	140586695	2	-	27260156	RDES	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.4443016163477145	[929]	[1097,1551,1453,1792]	7	hSpCas9	negative selection	8499950
140982235	140982258	2	+	27260156	RDES	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.22483333681401055	[340]	[347,563,444,477]	3	hSpCas9	negative selection	8527611
141810287	141810310	2	+	27260156	RDES	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.20997856578581098	[250]	[279,355,347,353]	3	hSpCas9	negative selection	8527612
140982169	140982192	2	-	27260156	RDES	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	-0.15986636071125748	[427]	[452,416,465,405]	-3	hSpCas9	negative selection	8527613
140951895	140951918	2	-	27260156	PC3	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	0.44117108678698447	[17]	[7,2,82,33]	8	hSpCas9	negative selection	8584603
141810345	141810368	2	+	27260156	PC3	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.19007665908433125	[792]	[504,502,1237,757]	-4	hSpCas9	negative selection	8584604
140951859	140951882	2	-	27260156	PC3	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	-0.15782102320997515	[341]	[203,237,440,413]	-4	hSpCas9	negative selection	8584605
140833638	140833661	2	-	27260156	PC3	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.39545474919433854	[1116]	[1069,1212,2655,1405]	8	hSpCas9	negative selection	8616084
140704933	140704956	2	-	27260156	PC3	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.9195860513118763	[383]	[472,701,975,887]	9	hSpCas9	negative selection	8619400
140586627	140586650	2	+	27260156	PC3	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.3774596089129594	[242]	[187,320,425,395]	7	hSpCas9	negative selection	8621198
140586669	140586692	2	+	27260156	PC3	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.3303675524430024	[443]	[333,538,1005,568]	7	hSpCas9	negative selection	8621199
140586623	140586646	2	-	27260156	PC3	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.2080043489019064	[766]	[468,681,1222,495]	-5	hSpCas9	negative selection	8621200
140586672	140586695	2	-	27260156	PC3	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.30887820011439215	[929]	[733,1065,2100,1135]	6	hSpCas9	negative selection	8621201
140982235	140982258	2	+	27260156	PC3	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.29863124150668047	[340]	[144,320,531,236]	-6	hSpCas9	negative selection	8648862
141810287	141810310	2	+	27260156	PC3	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.6237230061054317	[250]	[250,359,518,489]	9	hSpCas9	negative selection	8648863
140982169	140982192	2	-	27260156	PC3	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.1859998872787666	[427]	[303,521,676,544]	4	hSpCas9	negative selection	8648864
140951895	140951918	2	-	27260156	PATU8988T	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	1.5251257204211393	[17]	[3,34,20,146]	9	hSpCas9	negative selection	8705854
141810345	141810368	2	+	27260156	PATU8988T	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.041371744423520984	[792]	[594,848,669,1069]	0	hSpCas9	negative selection	8705855
140951859	140951882	2	-	27260156	PATU8988T	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.3085656691688111	[341]	[437,355,455,378]	5	hSpCas9	negative selection	8705856
140833638	140833661	2	-	27260156	PATU8988T	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.5189468356615297	[1116]	[1227,1677,1554,1753]	8	hSpCas9	negative selection	8737335
140704933	140704956	2	-	27260156	PATU8988T	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.9493474152067553	[383]	[669,841,694,666]	9	hSpCas9	negative selection	8740651
140586627	140586650	2	+	27260156	PATU8988T	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.7736304830264542	[242]	[364,401,506,323]	9	hSpCas9	negative selection	8742449
140586669	140586692	2	+	27260156	PATU8988T	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.1357581143359692	[443]	[462,336,599,470]	2	hSpCas9	negative selection	8742450
140586623	140586646	2	-	27260156	PATU8988T	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	0.34008996285172644	[766]	[947,818,829,1163]	6	hSpCas9	negative selection	8742451
140586672	140586695	2	-	27260156	PATU8988T	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.35794743329557055	[929]	[1043,1122,1196,1246]	6	hSpCas9	negative selection	8742452
140982235	140982258	2	+	27260156	PATU8988T	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.46496740274458115	[340]	[560,547,349,362]	7	hSpCas9	negative selection	8770113
141810287	141810310	2	+	27260156	PATU8988T	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.06267603745704198	[250]	[382,284,158,184]	1	hSpCas9	negative selection	8770114
140982169	140982192	2	-	27260156	PATU8988T	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.2849828951112445	[427]	[574,424,436,577]	5	hSpCas9	negative selection	8770115
140951895	140951918	2	-	27260156	T47D	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.09730127837602964	[17]	[24,9,7,36]	-2	hSpCas9	negative selection	8827105
141810345	141810368	2	+	27260156	T47D	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.03157364665247542	[792]	[1004,795,969,1020]	0	hSpCas9	negative selection	8827106
140951859	140951882	2	-	27260156	T47D	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.032702751198213476	[341]	[454,370,391,415]	0	hSpCas9	negative selection	8827107
140833638	140833661	2	-	27260156	T47D	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.4975557883285824	[1116]	[1989,1676,1865,1828]	9	hSpCas9	negative selection	8858586
140704933	140704956	2	-	27260156	T47D	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.0911761714165569	[383]	[966,895,883,1074]	9	hSpCas9	negative selection	8861902
140586627	140586650	2	+	27260156	T47D	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.4027334095275755	[242]	[345,394,396,355]	8	hSpCas9	negative selection	8863700
140586669	140586692	2	+	27260156	T47D	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.27692498589626924	[443]	[558,593,678,677]	6	hSpCas9	negative selection	8863701
140586623	140586646	2	-	27260156	T47D	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	0.05406300807232156	[766]	[900,990,892,919]	1	hSpCas9	negative selection	8863702
140586672	140586695	2	-	27260156	T47D	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.5973411451987432	[929]	[1649,1564,1676,1670]	9	hSpCas9	negative selection	8863703
140982235	140982258	2	+	27260156	T47D	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.01359203803686232	[340]	[493,311,425,378]	0	hSpCas9	negative selection	8891364
141810287	141810310	2	+	27260156	T47D	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.47649953513183485	[250]	[458,277,459,441]	8	hSpCas9	negative selection	8891365
140982169	140982192	2	-	27260156	T47D	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.05107034462222104	[427]	[479,575,513,489]	1	hSpCas9	negative selection	8891366
140951895	140951918	2	-	27260156	SU8686	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	1.1123943621252077	[17]	[24,43,35,51]	9	hSpCas9	negative selection	8948356
141810345	141810368	2	+	27260156	SU8686	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.13088244657389903	[792]	[850,779,787,1059]	2	hSpCas9	negative selection	8948357
140951859	140951882	2	-	27260156	SU8686	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.22957940732327725	[341]	[428,314,385,476]	4	hSpCas9	negative selection	8948358
140833638	140833661	2	-	27260156	SU8686	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.5657024742380077	[1116]	[1401,1573,1756,1890]	8	hSpCas9	negative selection	8979837
140704933	140704956	2	-	27260156	SU8686	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.0951738095563335	[383]	[721,730,813,1037]	9	hSpCas9	negative selection	8983153
140586627	140586650	2	+	27260156	SU8686	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.09208599609552992	[242]	[231,307,207,274]	1	hSpCas9	negative selection	8984951
140586669	140586692	2	+	27260156	SU8686	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.2200811654923774	[443]	[391,374,658,684]	4	hSpCas9	negative selection	8984952
140586623	140586646	2	-	27260156	SU8686	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	0.08967055433693027	[766]	[887,702,762,893]	1	hSpCas9	negative selection	8984953
140586672	140586695	2	-	27260156	SU8686	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.8090636008033514	[929]	[1567,1590,1587,1728]	9	hSpCas9	negative selection	8984954
140982235	140982258	2	+	27260156	SU8686	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.14170640549768815	[340]	[484,315,306,373]	2	hSpCas9	negative selection	9012615
141810287	141810310	2	+	27260156	SU8686	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.7051984195311987	[250]	[354,247,462,615]	9	hSpCas9	negative selection	9012616
140982169	140982192	2	-	27260156	SU8686	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	-0.6566923184742353	[427]	[292,196,328,262]	-7	hSpCas9	negative selection	9012617
140951895	140951918	2	-	27260156	SKES1	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.5137104777164714	[17]	[12,9,4,20]	-8	hSpCas9	negative selection	9069607
141810345	141810368	2	+	27260156	SKES1	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.1601574011639919	[792]	[844,730,637,640]	-3	hSpCas9	negative selection	9069608
140951859	140951882	2	-	27260156	SKES1	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.12706067413680788	[341]	[359,524,344,283]	2	hSpCas9	negative selection	9069609
140833638	140833661	2	-	27260156	SKES1	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.4208898162196426	[1116]	[1483,1982,1442,1141]	8	hSpCas9	negative selection	9101088
140704933	140704956	2	-	27260156	SKES1	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.9799009531163959	[383]	[1034,752,639,639]	9	hSpCas9	negative selection	9104404
140586627	140586650	2	+	27260156	SKES1	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	-0.31996158652793816	[242]	[219,239,123,199]	-6	hSpCas9	negative selection	9106202
140586669	140586692	2	+	27260156	SKES1	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.15269364299493846	[443]	[588,505,449,440]	3	hSpCas9	negative selection	9106203
140586623	140586646	2	-	27260156	SKES1	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.09295814554488868	[766]	[963,877,535,558]	-2	hSpCas9	negative selection	9106204
140586672	140586695	2	-	27260156	SKES1	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.4383553427646878	[929]	[1273,1498,1428,886]	8	hSpCas9	negative selection	9106205
140982235	140982258	2	+	27260156	SKES1	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.2302346971686599	[340]	[371,287,281,232]	-5	hSpCas9	negative selection	9133866
141810287	141810310	2	+	27260156	SKES1	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.2400545645781048	[250]	[290,305,314,270]	5	hSpCas9	negative selection	9133867
140982169	140982192	2	-	27260156	SKES1	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.06045242271736517	[427]	[488,501,257,531]	1	hSpCas9	negative selection	9133868
140951895	140951918	2	-	27260156	TOV112D	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.511199415054584	[17]	[3,36,7,6]	-7	hSpCas9	negative selection	9190858
141810345	141810368	2	+	27260156	TOV112D	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.02345493326357795	[792]	[780,926,627,822]	0	hSpCas9	negative selection	9190859
140951859	140951882	2	-	27260156	TOV112D	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.5449101091996603	[341]	[324,769,531,424]	8	hSpCas9	negative selection	9190860
140833638	140833661	2	-	27260156	TOV112D	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.46496452466133875	[1116]	[1703,2144,1397,1100]	8	hSpCas9	negative selection	9222339
140704933	140704956	2	-	27260156	TOV112D	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.9618177085220395	[383]	[697,1086,611,678]	9	hSpCas9	negative selection	9225655
140586627	140586650	2	+	27260156	TOV112D	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.2584156817082197	[242]	[327,360,265,230]	5	hSpCas9	negative selection	9227453
140586669	140586692	2	+	27260156	TOV112D	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.1596166237555829	[443]	[351,930,419,380]	3	hSpCas9	negative selection	9227454
140586623	140586646	2	-	27260156	TOV112D	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	0.057894913660226255	[766]	[688,1205,776,620]	1	hSpCas9	negative selection	9227455
140586672	140586695	2	-	27260156	TOV112D	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.5942644495130291	[929]	[1610,1926,1262,978]	9	hSpCas9	negative selection	9227456
140982235	140982258	2	+	27260156	TOV112D	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.2230388297814462	[340]	[419,486,405,306]	4	hSpCas9	negative selection	9255117
141810287	141810310	2	+	27260156	TOV112D	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.14396619958859036	[250]	[199,566,193,215]	2	hSpCas9	negative selection	9255118
140982169	140982192	2	-	27260156	TOV112D	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.274832726795861	[427]	[504,1106,257,351]	5	hSpCas9	negative selection	9255119
140951895	140951918	2	-	27260156	TC71	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.2336541101241636	[17]	[20,15,8,19]	-6	hSpCas9	negative selection	9312109
141810345	141810368	2	+	27260156	TC71	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	-0.08963016515973865	[792]	[734,839,791,831]	-2	hSpCas9	negative selection	9312110
140951859	140951882	2	-	27260156	TC71	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	-0.1499009151931585	[341]	[327,411,285,294]	-4	hSpCas9	negative selection	9312111
140833638	140833661	2	-	27260156	TC71	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.3685624094195825	[1116]	[1529,1465,1485,1713]	8	hSpCas9	negative selection	9343590
140704933	140704956	2	-	27260156	TC71	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	0.8848550977287295	[383]	[683,744,800,813]	9	hSpCas9	negative selection	9346906
140586627	140586650	2	+	27260156	TC71	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.22860071390572856	[242]	[264,307,346,299]	5	hSpCas9	negative selection	9348704
140586669	140586692	2	+	27260156	TC71	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	0.003285131944381181	[443]	[509,414,448,537]	0	hSpCas9	negative selection	9348705
140586623	140586646	2	-	27260156	TC71	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.09023907368491435	[766]	[758,758,824,742]	-2	hSpCas9	negative selection	9348706
140586672	140586695	2	-	27260156	TC71	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.4412953313397132	[929]	[1331,1493,1244,1346]	8	hSpCas9	negative selection	9348707
140982235	140982258	2	+	27260156	TC71	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	-0.025886814240286715	[340]	[260,338,479,353]	0	hSpCas9	negative selection	9376368
141810287	141810310	2	+	27260156	TC71	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.29589841885466284	[250]	[327,388,305,296]	7	hSpCas9	negative selection	9376369
140982169	140982192	2	-	27260156	TC71	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	-0.06058902789883991	[427]	[379,463,463,452]	-1	hSpCas9	negative selection	9376370
140951895	140951918	2	-	27260156	TC32	viability	ACCCAATTCGTATGCAAAAGTGG	LRP1B	ENSG00000168702	-0.5406465240099658	[17]	[14,3,29,1]	-8	hSpCas9	negative selection	9433360
141810345	141810368	2	+	27260156	TC32	viability	AGACACAAGTCACGTGATCGTGG	LRP1B	ENSG00000168702	0.07891627405651402	[792]	[693,774,844,810]	1	hSpCas9	negative selection	9433361
140951859	140951882	2	-	27260156	TC32	viability	AGCAAATGGCACTGCGACTCTGG	LRP1B	ENSG00000168702	0.242444885614542	[341]	[277,259,485,562]	4	hSpCas9	negative selection	9433362
140833638	140833661	2	-	27260156	TC32	viability	TCTTGGAAACTGTGACTTTAAAG	LRP1B	ENSG00000168702	0.4706557717397708	[1116]	[1561,828,1969,1700]	7	hSpCas9	negative selection	9464841
140704933	140704956	2	-	27260156	TC32	viability	CTTTTTGCCATTACTTTTAATAG	LRP1B	ENSG00000168702	1.2333221111573778	[383]	[721,781,1015,892]	9	hSpCas9	negative selection	9468157
140586627	140586650	2	+	27260156	TC32	viability	CTCTTCATCCAGTAGCACAGAGG	LRP1B	ENSG00000168702	0.2695641416446678	[242]	[304,130,405,319]	5	hSpCas9	negative selection	9469955
140586669	140586692	2	+	27260156	TC32	viability	GTGCCAATGAATGCTGAATGGGG	LRP1B	ENSG00000168702	-0.21040363948014085	[443]	[286,219,521,491]	-4	hSpCas9	negative selection	9469956
140586623	140586646	2	-	27260156	TC32	viability	TGTGCTACTGGATGAAGAGTGGG	LRP1B	ENSG00000168702	-0.3179208750926467	[766]	[516,307,918,714]	-5	hSpCas9	negative selection	9469957
140586672	140586695	2	-	27260156	TC32	viability	GTCCCCCATTCAGCATTCATTGG	LRP1B	ENSG00000168702	0.4381683683856068	[929]	[1067,919,1557,1305]	7	hSpCas9	negative selection	9469958
140982235	140982258	2	+	27260156	TC32	viability	GCCCATTTCCGCAAGAAAACTGG	LRP1B	ENSG00000168702	0.020468811327415293	[340]	[302,244,383,395]	0	hSpCas9	negative selection	9497619
141810287	141810310	2	+	27260156	TC32	viability	AAAGACTCGTCTGAATCATCAGG	LRP1B	ENSG00000168702	0.3092924809222001	[250]	[251,225,395,327]	5	hSpCas9	negative selection	9497620
140982169	140982192	2	-	27260156	TC32	viability	TGGTGACCAGACAGATGAAATGG	LRP1B	ENSG00000168702	0.10002585074729706	[427]	[368,418,490,440]	1	hSpCas9	negative selection	9497621
141055151	141055174	2	-	27869803	HPAFII	viability after 27 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.58925060235222	[383]	[318,290,NaN]	5	hSpCas9	negative selection	9571795
141062198	141062221	2	-	27869803	HPAFII	viability after 27 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.7333612409351971	[523]	[217,657,NaN]	6	hSpCas9	negative selection	9571796
141188509	141188532	2	+	27869803	HPAFII	viability after 27 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	0.9414659806306533	[375]	[251,485,NaN]	7	hSpCas9	negative selection	9571798
141480486	141480509	2	+	27869803	HPAFII	viability after 27 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	1.016007341796823	[127]	[110,156,NaN]	8	hSpCas9	negative selection	9571799
141810362	141810385	2	+	27869803	HPAFII	viability after 27 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	-1.109105569847487	[209]	[72,32,NaN]	-6	hSpCas9	negative selection	9571800
142130672	142130695	2	-	27869803	HPAFII	viability after 27 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-0.3148219276922386	[153]	[39,85,NaN]	-2	hSpCas9	negative selection	9571802
141055151	141055174	2	-	27869803	HPAFII	viability after 15 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.15311920788443556	[383]	[699,308,NaN]	1	hSpCas9	negative selection	9654244
141062198	141062221	2	-	27869803	HPAFII	viability after 15 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.31331123543409123	[523]	[589,767,NaN]	3	hSpCas9	negative selection	9654245
141188509	141188532	2	+	27869803	HPAFII	viability after 15 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	0.3484839480892714	[375]	[413,576,NaN]	4	hSpCas9	negative selection	9654247
141480486	141480509	2	+	27869803	HPAFII	viability after 15 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	-0.09735827330783753	[127]	[180,95,NaN]	-1	hSpCas9	negative selection	9654248
141810362	141810385	2	+	27869803	HPAFII	viability after 15 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	-1.2820790096791927	[209]	[151,55,NaN]	-8	hSpCas9	negative selection	9654249
142130672	142130695	2	-	27869803	HPAFII	viability after 15 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-0.058022155502329587	[153]	[166,153,NaN]	0	hSpCas9	negative selection	9654251
141055151	141055174	2	-	27869803	ASPC1	viability after 36 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.7359474022908765	[807]	[723,395,344]	7	hSpCas9	negative selection	9736693
141062198	141062221	2	-	27869803	ASPC1	viability after 36 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.06310421540539224	[1281]	[510,512,395]	0	hSpCas9	negative selection	9736694
141188509	141188532	2	+	27869803	ASPC1	viability after 36 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	0.1685410452421623	[803]	[506,270,212]	1	hSpCas9	negative selection	9736696
141480486	141480509	2	+	27869803	ASPC1	viability after 36 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	-2.8162514637888356	[442]	[19,11,30]	-9	hSpCas9	negative selection	9736697
141810362	141810385	2	+	27869803	ASPC1	viability after 36 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.2934045443207646	[384]	[9,153,279]	3	hSpCas9	negative selection	9736698
142130672	142130695	2	-	27869803	ASPC1	viability after 36 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	1.5988034396197608	[283]	[99,552,236]	9	hSpCas9	negative selection	9736700
141055151	141055174	2	-	27869803	PATU8988S	viability after 35 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	1.4791653240675506	[886]	[1187,802,NaN]	9	hSpCas9	negative selection	9819142
141062198	141062221	2	-	27869803	PATU8988S	viability after 35 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.3196123409867365	[1030]	[391,644,NaN]	3	hSpCas9	negative selection	9819143
141188509	141188532	2	+	27869803	PATU8988S	viability after 35 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	-0.19470803452939867	[887]	[307,316,NaN]	-2	hSpCas9	negative selection	9819145
141480486	141480509	2	+	27869803	PATU8988S	viability after 35 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	1.1792065409880101	[301]	[246,303,NaN]	9	hSpCas9	negative selection	9819146
141810362	141810385	2	+	27869803	PATU8988S	viability after 35 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.5139078926561627	[332]	[193,188,NaN]	6	hSpCas9	negative selection	9819147
142130672	142130695	2	-	27869803	PATU8988S	viability after 35 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	0.17013300483444116	[221]	[144,55,NaN]	2	hSpCas9	negative selection	9819149
141055151	141055174	2	-	27869803	PATU8988S	viability after 31 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	1.3797393325645761	[886]	[750,1135,NaN]	9	hSpCas9	negative selection	9901591
141062198	141062221	2	-	27869803	PATU8988S	viability after 31 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.27394465340250884	[1030]	[449,556,NaN]	3	hSpCas9	negative selection	9901592
141188509	141188532	2	+	27869803	PATU8988S	viability after 31 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	-0.17796118374585934	[887]	[279,354,NaN]	-2	hSpCas9	negative selection	9901594
141480486	141480509	2	+	27869803	PATU8988S	viability after 31 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	0.8156125100132042	[301]	[141,300,NaN]	8	hSpCas9	negative selection	9901595
141810362	141810385	2	+	27869803	PATU8988S	viability after 31 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	0.35572906361830176	[332]	[128,221,NaN]	4	hSpCas9	negative selection	9901596
142130672	142130695	2	-	27869803	PATU8988S	viability after 31 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	0.43989576870408087	[221]	[116,123,NaN]	5	hSpCas9	negative selection	9901598
141055151	141055174	2	-	27869803	HPAFII	viability after 35 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.6757316050834313	[383]	[199,434,NaN]	4	hSpCas9	negative selection	9984040
141062198	141062221	2	-	27869803	HPAFII	viability after 35 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	1.1094637211081244	[523]	[125,1074,NaN]	7	hSpCas9	negative selection	9984041
141188509	141188532	2	+	27869803	HPAFII	viability after 35 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	1.4992058241264556	[375]	[364,732,NaN]	8	hSpCas9	negative selection	9984043
141480486	141480509	2	+	27869803	HPAFII	viability after 35 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	0.18945982904789638	[127]	[95,48,NaN]	1	hSpCas9	negative selection	9984044
141810362	141810385	2	+	27869803	HPAFII	viability after 35 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	-0.9583857499596189	[209]	[65,41,NaN]	-5	hSpCas9	negative selection	9984045
142130672	142130695	2	-	27869803	HPAFII	viability after 35 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-0.9338374011983663	[153]	[13,70,NaN]	-5	hSpCas9	negative selection	9984047
141055151	141055174	2	-	27869803	HPAFII	viability after 31 days	CGGACTTGTCGCTGCAGGACTGG	LRP1B	ENSG00000168702	0.42899278389083817	[383]	[214,371,NaN]	3	hSpCas9	negative selection	10066489
141062198	141062221	2	-	27869803	HPAFII	viability after 31 days	TGGATGGGATGAACCGAACAAGG	LRP1B	ENSG00000168702	0.7121104449642668	[523]	[185,803,NaN]	5	hSpCas9	negative selection	10066490
141188509	141188532	2	+	27869803	HPAFII	viability after 31 days	CAAAGATCCGGTCACCGACATGG	LRP1B	ENSG00000168702	0.7637490587420552	[375]	[252,472,NaN]	5	hSpCas9	negative selection	10066492
141480486	141480509	2	+	27869803	HPAFII	viability after 31 days	GGCAAGCAATGTGATTCAAGGGG	LRP1B	ENSG00000168702	-0.08265567902176585	[127]	[52,83,NaN]	0	hSpCas9	negative selection	10066493
141810362	141810385	2	+	27869803	HPAFII	viability after 31 days	TCGTGGCAAAGAAATTCACCAGG	LRP1B	ENSG00000168702	-0.5836304864841	[209]	[92,62,NaN]	-4	hSpCas9	negative selection	10066494
142130672	142130695	2	-	27869803	HPAFII	viability after 31 days	GGGATTATTGCCGATTGCCAGGG	LRP1B	ENSG00000168702	-1.117683512096187	[153]	[35,43,NaN]	-6	hSpCas9	negative selection	10066496
140886158	140886181	2	-	28162770	P31FUJ	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	-0.4569255138299424	[138]	[118]	-4	hSpCas9	negative selection	10185802
140908055	140908078	2	-	28162770	P31FUJ	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	0.2366830788868417	[272]	[377]	2	hSpCas9	negative selection	10185803
140867737	140867760	2	+	28162770	P31FUJ	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	-0.17531670975361846	[122]	[127]	-2	hSpCas9	negative selection	10185804
140238192	140238215	2	-	28162770	P31FUJ	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	0.27124030092321005	[109]	[155]	3	hSpCas9	negative selection	10185805
141188477	141188500	2	+	28162770	P31FUJ	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	-0.11846952893538365	[96]	[104]	-1	hSpCas9	negative selection	10185806
141015865	141015888	2	-	28162770	P31FUJ	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	-0.2630168174613864	[192]	[188]	-3	hSpCas9	negative selection	10185807
141013697	141013720	2	+	28162770	P31FUJ	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	0.31628325997818085	[94]	[138]	3	hSpCas9	negative selection	10185808
141013611	141013634	2	-	28162770	P31FUJ	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	0.2626087113284851	[143]	[202]	3	hSpCas9	negative selection	10185809
140989593	140989616	2	-	28162770	P31FUJ	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	0.7809509506529517	[260]	[526]	8	hSpCas9	negative selection	10185810
140923082	140923105	2	+	28162770	P31FUJ	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	0.3709375033374058	[228]	[347]	4	hSpCas9	negative selection	10185811
140886158	140886181	2	-	28162770	TF1	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	NaN	[NaN]	[17]	1	hSpCas9	negative selection	10355168
140908055	140908078	2	-	28162770	TF1	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	NaN	[NaN]	[234]	1	hSpCas9	negative selection	10355169
140867737	140867760	2	+	28162770	TF1	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	NaN	[NaN]	[116]	1	hSpCas9	negative selection	10355170
140238192	140238215	2	-	28162770	TF1	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	NaN	[NaN]	[156]	1	hSpCas9	negative selection	10355171
141188477	141188500	2	+	28162770	TF1	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	NaN	[NaN]	[71]	1	hSpCas9	negative selection	10355172
141015865	141015888	2	-	28162770	TF1	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	NaN	[NaN]	[137]	1	hSpCas9	negative selection	10355173
141013697	141013720	2	+	28162770	TF1	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	NaN	[NaN]	[177]	1	hSpCas9	negative selection	10355174
141013611	141013634	2	-	28162770	TF1	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	NaN	[NaN]	[67]	1	hSpCas9	negative selection	10355175
140989593	140989616	2	-	28162770	TF1	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	NaN	[NaN]	[315]	1	hSpCas9	negative selection	10355176
140923082	140923105	2	+	28162770	TF1	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	NaN	[NaN]	[128]	1	hSpCas9	negative selection	10355177
140886158	140886181	2	-	28162770	SKM1	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	0.19685732922931026	[37]	[76]	2	hSpCas9	negative selection	10524534
140908055	140908078	2	-	28162770	SKM1	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	1.0863678265124261	[64]	[243]	8	hSpCas9	negative selection	10524535
140867737	140867760	2	+	28162770	SKM1	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	-1.9649596518640484	[52]	[23]	-8	hSpCas9	negative selection	10524536
140238192	140238215	2	-	28162770	SKM1	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	-0.4143437291087592	[48]	[64]	-3	hSpCas9	negative selection	10524537
141188477	141188500	2	+	28162770	SKM1	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	0.3371968968272484	[29]	[66]	3	hSpCas9	negative selection	10524538
141015865	141015888	2	-	28162770	SKM1	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	-0.24911202960142437	[79]	[118]	-2	hSpCas9	negative selection	10524539
141013697	141013720	2	+	28162770	SKM1	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	0.46340052084024286	[31]	[77]	4	hSpCas9	negative selection	10524540
141013611	141013634	2	-	28162770	SKM1	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	0.8009286528981712	[24]	[76]	7	hSpCas9	negative selection	10524541
140989593	140989616	2	-	28162770	SKM1	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	-0.05781463512077495	[62]	[106]	0	hSpCas9	negative selection	10524542
140923082	140923105	2	+	28162770	SKM1	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	1.0054188470897043	[50]	[180]	8	hSpCas9	negative selection	10524543
140886158	140886181	2	-	28162770	SKM1	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	0.19685732922931026	[37]	[76]	2	hSpCas9	negative selection	10693900
140908055	140908078	2	-	28162770	SKM1	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	1.0863678265124261	[64]	[243]	8	hSpCas9	negative selection	10693901
140867737	140867760	2	+	28162770	SKM1	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	-1.9649596518640484	[52]	[23]	-8	hSpCas9	negative selection	10693902
140238192	140238215	2	-	28162770	SKM1	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	-0.4143437291087592	[48]	[64]	-3	hSpCas9	negative selection	10693903
141188477	141188500	2	+	28162770	SKM1	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	0.3371968968272484	[29]	[66]	3	hSpCas9	negative selection	10693904
141015865	141015888	2	-	28162770	SKM1	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	-0.24911202960142437	[79]	[118]	-2	hSpCas9	negative selection	10693905
141013697	141013720	2	+	28162770	SKM1	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	0.46340052084024286	[31]	[77]	4	hSpCas9	negative selection	10693906
141013611	141013634	2	-	28162770	SKM1	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	0.8009286528981712	[24]	[76]	7	hSpCas9	negative selection	10693907
140989593	140989616	2	-	28162770	SKM1	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	-0.05781463512077495	[62]	[106]	0	hSpCas9	negative selection	10693908
140923082	140923105	2	+	28162770	SKM1	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	1.0054188470897043	[50]	[180]	8	hSpCas9	negative selection	10693909
140886158	140886181	2	-	28162770	PL21	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	-0.42854426366115383	[200]	[64]	-3	hSpCas9	negative selection	10863266
140908055	140908078	2	-	28162770	PL21	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	0.285869488515204	[244]	[129]	2	hSpCas9	negative selection	10863267
140867737	140867760	2	+	28162770	PL21	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	-0.24043297689666113	[189]	[69]	-2	hSpCas9	negative selection	10863268
140238192	140238215	2	-	28162770	PL21	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	-1.0477878989542655	[132]	[27]	-6	hSpCas9	negative selection	10863269
141188477	141188500	2	+	28162770	PL21	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	-0.3714023704695145	[106]	[35]	-3	hSpCas9	negative selection	10863270
141015865	141015888	2	-	28162770	PL21	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	-0.41219932516314106	[265]	[86]	-3	hSpCas9	negative selection	10863271
141013697	141013720	2	+	28162770	PL21	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	1.8168109749378143	[104]	[160]	9	hSpCas9	negative selection	10863272
141013611	141013634	2	-	28162770	PL21	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	0.4371788117901696	[111]	[65]	4	hSpCas9	negative selection	10863273
140989593	140989616	2	-	28162770	PL21	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	0.7921915399967957	[202]	[152]	6	hSpCas9	negative selection	10863274
140923082	140923105	2	+	28162770	PL21	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	-1.7998603855106798	[199]	[24]	-8	hSpCas9	negative selection	10863275
140886158	140886181	2	-	28162770	P31FUJ	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	-0.4569255138299424	[138]	[118]	-4	hSpCas9	negative selection	11032632
140908055	140908078	2	-	28162770	P31FUJ	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	0.2366830788868417	[272]	[377]	2	hSpCas9	negative selection	11032633
140867737	140867760	2	+	28162770	P31FUJ	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	-0.17531670975361846	[122]	[127]	-2	hSpCas9	negative selection	11032634
140238192	140238215	2	-	28162770	P31FUJ	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	0.27124030092321005	[109]	[155]	3	hSpCas9	negative selection	11032635
141188477	141188500	2	+	28162770	P31FUJ	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	-0.11846952893538365	[96]	[104]	-1	hSpCas9	negative selection	11032636
141015865	141015888	2	-	28162770	P31FUJ	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	-0.2630168174613864	[192]	[188]	-3	hSpCas9	negative selection	11032637
141013697	141013720	2	+	28162770	P31FUJ	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	0.31628325997818085	[94]	[138]	3	hSpCas9	negative selection	11032638
141013611	141013634	2	-	28162770	P31FUJ	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	0.2626087113284851	[143]	[202]	3	hSpCas9	negative selection	11032639
140989593	140989616	2	-	28162770	P31FUJ	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	0.7809509506529517	[260]	[526]	8	hSpCas9	negative selection	11032640
140923082	140923105	2	+	28162770	P31FUJ	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	0.3709375033374058	[228]	[347]	4	hSpCas9	negative selection	11032641
140886158	140886181	2	-	28162770	OCIAML5	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	-0.6962718982565729	[113]	[126]	-4	hSpCas9	negative selection	11201998
140908055	140908078	2	-	28162770	OCIAML5	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	0.6124659194661657	[153]	[424]	5	hSpCas9	negative selection	11201999
140867737	140867760	2	+	28162770	OCIAML5	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	1.1101313964236186	[57]	[225]	8	hSpCas9	negative selection	11202000
140238192	140238215	2	-	28162770	OCIAML5	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	1.1252133526359194	[63]	[251]	8	hSpCas9	negative selection	11202001
141188477	141188500	2	+	28162770	OCIAML5	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	1.0488002371167515	[63]	[238]	8	hSpCas9	negative selection	11202002
141015865	141015888	2	-	28162770	OCIAML5	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	0.3326733089930526	[182]	[415]	3	hSpCas9	negative selection	11202003
141013697	141013720	2	+	28162770	OCIAML5	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	0.056959769088512746	[89]	[168]	0	hSpCas9	negative selection	11202004
141013611	141013634	2	-	28162770	OCIAML5	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	1.7710310587439304	[55]	[344]	9	hSpCas9	negative selection	11202005
140989593	140989616	2	-	28162770	OCIAML5	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	0.43357740669858885	[152]	[372]	4	hSpCas9	negative selection	11202006
140923082	140923105	2	+	28162770	OCIAML5	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	-0.1192586021714467	[138]	[230]	-1	hSpCas9	negative selection	11202007
140886158	140886181	2	-	28162770	EOL1	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	-0.09563011036709579	[287]	[141]	0	hSpCas9	negative selection	11371364
140908055	140908078	2	-	28162770	EOL1	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	-0.45287543590853147	[264]	[101]	-3	hSpCas9	negative selection	11371365
140867737	140867760	2	+	28162770	EOL1	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	0.10368091979538321	[294]	[166]	0	hSpCas9	negative selection	11371366
140238192	140238215	2	-	28162770	EOL1	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	1.2178121082057534	[243]	[298]	8	hSpCas9	negative selection	11371367
141188477	141188500	2	+	28162770	EOL1	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	-0.6457679531862202	[195]	[65]	-5	hSpCas9	negative selection	11371368
141015865	141015888	2	-	28162770	EOL1	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	-0.07865466046780945	[450]	[224]	0	hSpCas9	negative selection	11371369
141013697	141013720	2	+	28162770	EOL1	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	-0.2353235652078549	[142]	[63]	-2	hSpCas9	negative selection	11371370
141013611	141013634	2	-	28162770	EOL1	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	0.5544361431732069	[136]	[105]	5	hSpCas9	negative selection	11371371
140989593	140989616	2	-	28162770	EOL1	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	0.3132739937335312	[248]	[162]	3	hSpCas9	negative selection	11371372
140923082	140923105	2	+	28162770	EOL1	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	-0.8690013509620389	[207]	[59]	-6	hSpCas9	negative selection	11371373
140886158	140886181	2	-	28162770	MOLM13	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	1.7624726232531935	[244]	[600]	9	hSpCas9	negative selection	11540730
140908055	140908078	2	-	28162770	MOLM13	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	0.2502155091106607	[406]	[349]	1	hSpCas9	negative selection	11540731
140867737	140867760	2	+	28162770	MOLM13	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	-1.072678999818124	[191]	[65]	-5	hSpCas9	negative selection	11540732
140238192	140238215	2	-	28162770	MOLM13	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	0.5210007180041413	[159]	[165]	4	hSpCas9	negative selection	11540733
141188477	141188500	2	+	28162770	MOLM13	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	0.4558165492440037	[119]	[118]	3	hSpCas9	negative selection	11540734
141015865	141015888	2	-	28162770	MOLM13	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	0.19313249068624355	[345]	[285]	1	hSpCas9	negative selection	11540735
141013697	141013720	2	+	28162770	MOLM13	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	0.3192453001894433	[142]	[128]	2	hSpCas9	negative selection	11540736
141013611	141013634	2	-	28162770	MOLM13	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	2.2979643801022664	[98]	[351]	9	hSpCas9	negative selection	11540737
140989593	140989616	2	-	28162770	MOLM13	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	0.38158953515035865	[309]	[291]	3	hSpCas9	negative selection	11540738
140923082	140923105	2	+	28162770	MOLM13	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	-1.2169083867563724	[343]	[106]	-6	hSpCas9	negative selection	11540739
140886158	140886181	2	-	28162770	HEL	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	0.45487881662333807	[171]	[150]	4	hSpCas9	negative selection	11710096
140908055	140908078	2	-	28162770	HEL	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	0.31821362562695565	[277]	[221]	2	hSpCas9	negative selection	11710097
140867737	140867760	2	+	28162770	HEL	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	1.0185411679961005	[204]	[265]	8	hSpCas9	negative selection	11710098
140238192	140238215	2	-	28162770	HEL	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	0.6895330434792979	[181]	[187]	6	hSpCas9	negative selection	11710099
141188477	141188500	2	+	28162770	HEL	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	0.126340617762272	[112]	[78]	1	hSpCas9	negative selection	11710100
141015865	141015888	2	-	28162770	HEL	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	0.19527985502913559	[299]	[219]	1	hSpCas9	negative selection	11710101
141013697	141013720	2	+	28162770	HEL	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	1.2622585547578817	[109]	[168]	9	hSpCas9	negative selection	11710102
141013611	141013634	2	-	28162770	HEL	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	0.3768447720273226	[100]	[83]	3	hSpCas9	negative selection	11710103
140989593	140989616	2	-	28162770	HEL	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	0.32081073711299446	[214]	[171]	2	hSpCas9	negative selection	11710104
140923082	140923105	2	+	28162770	HEL	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	0.6981155890367302	[229]	[238]	6	hSpCas9	negative selection	11710105
140886158	140886181	2	-	28162770	MV411	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	0.2147713618624532	[133]	[130]	1	hSpCas9	negative selection	11879462
140908055	140908078	2	-	28162770	MV411	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	1.0547924728403792	[203]	[356]	8	hSpCas9	negative selection	11879463
140867737	140867760	2	+	28162770	MV411	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	0.7987407401527001	[158]	[232]	7	hSpCas9	negative selection	11879464
140238192	140238215	2	-	28162770	MV411	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	0.16872557476873473	[112]	[106]	1	hSpCas9	negative selection	11879465
141188477	141188500	2	+	28162770	MV411	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	0.04232312087816292	[82]	[71]	0	hSpCas9	negative selection	11879466
141015865	141015888	2	-	28162770	MV411	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	0.23240934155044335	[192]	[190]	2	hSpCas9	negative selection	11879467
141013697	141013720	2	+	28162770	MV411	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	1.296347151263722	[86]	[179]	9	hSpCas9	negative selection	11879468
141013611	141013634	2	-	28162770	MV411	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	-0.8790948551461566	[130]	[59]	-6	hSpCas9	negative selection	11879469
140989593	140989616	2	-	28162770	MV411	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	0.6680132336030491	[129]	[173]	6	hSpCas9	negative selection	11879470
140923082	140923105	2	+	28162770	MV411	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	1.754644893989486	[107]	[306]	9	hSpCas9	negative selection	11879471
140886158	140886181	2	-	28162770	MONOMAC1	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	0.10552592296087754	[119]	[147]	1	hSpCas9	negative selection	12048828
140908055	140908078	2	-	28162770	MONOMAC1	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	-0.40739671290110463	[198]	[171]	-4	hSpCas9	negative selection	12048829
140867737	140867760	2	+	28162770	MONOMAC1	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	1.9215197632923544	[107]	[468]	9	hSpCas9	negative selection	12048830
140238192	140238215	2	-	28162770	MONOMAC1	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	0.06885721291348074	[83]	[100]	0	hSpCas9	negative selection	12048831
141188477	141188500	2	+	28162770	MONOMAC1	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	1.1858202464701404	[50]	[132]	9	hSpCas9	negative selection	12048832
141015865	141015888	2	-	28162770	MONOMAC1	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	0.2180006522192901	[176]	[235]	2	hSpCas9	negative selection	12048833
141013697	141013720	2	+	28162770	MONOMAC1	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	0.7231098452512318	[64]	[122]	7	hSpCas9	negative selection	12048834
141013611	141013634	2	-	28162770	MONOMAC1	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	1.01928105986721	[67]	[157]	8	hSpCas9	negative selection	12048835
140989593	140989616	2	-	28162770	MONOMAC1	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	0.09841903646661766	[131]	[161]	1	hSpCas9	negative selection	12048836
140923082	140923105	2	+	28162770	MONOMAC1	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	-0.2404294425729344	[134]	[130]	-2	hSpCas9	negative selection	12048837
140886158	140886181	2	-	28162770	OCIAML2	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	-0.13131965212656233	[32]	[166]	-1	hSpCas9	negative selection	12218194
140908055	140908078	2	-	28162770	OCIAML2	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	0.9232134517675592	[44]	[472]	8	hSpCas9	negative selection	12218195
140867737	140867760	2	+	28162770	OCIAML2	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	0.624527407798179	[21]	[187]	6	hSpCas9	negative selection	12218196
140238192	140238215	2	-	28162770	OCIAML2	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	-0.4056743834013913	[37]	[158]	-3	hSpCas9	negative selection	12218197
141188477	141188500	2	+	28162770	OCIAML2	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	1.114332675478995	[10]	[131]	9	hSpCas9	negative selection	12218198
141015865	141015888	2	-	28162770	OCIAML2	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	0.5375441062035389	[43]	[353]	5	hSpCas9	negative selection	12218199
141013697	141013720	2	+	28162770	OCIAML2	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	1.5997595026492368	[9]	[167]	9	hSpCas9	negative selection	12218200
141013611	141013634	2	-	28162770	OCIAML2	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	0.36077057078209385	[16]	[120]	3	hSpCas9	negative selection	12218201
140989593	140989616	2	-	28162770	OCIAML2	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	0.14734773270695806	[35]	[220]	1	hSpCas9	negative selection	12218202
140923082	140923105	2	+	28162770	OCIAML2	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	-0.3970486928610538	[42]	[180]	-3	hSpCas9	negative selection	12218203
140886158	140886181	2	-	28162770	OCIAML3	viability	GTAGAAGACAGAATATACCGGGG	LRP1B	ENSG00000168702	-0.5615861626317857	[43]	[89]	-4	hSpCas9	negative selection	12387560
140908055	140908078	2	-	28162770	OCIAML3	viability	GGAGATGCATCAACAAAGCATGG	LRP1B	ENSG00000168702	-0.4071295056006537	[46]	[106]	-3	hSpCas9	negative selection	12387561
140867737	140867760	2	+	28162770	OCIAML3	viability	ATAGAGACACAGCAAAGGGATGG	LRP1B	ENSG00000168702	0.5877427965149389	[53]	[244]	5	hSpCas9	negative selection	12387562
140238192	140238215	2	-	28162770	OCIAML3	viability	GTAGATCATGATCACAACGATGG	LRP1B	ENSG00000168702	0.21334728173344097	[29]	[104]	2	hSpCas9	negative selection	12387563
141188477	141188500	2	+	28162770	OCIAML3	viability	GGTGACACATACAGAACCGTTGG	LRP1B	ENSG00000168702	1.7697406302578265	[16]	[174]	9	hSpCas9	negative selection	12387564
141015865	141015888	2	-	28162770	OCIAML3	viability	GATGAAATAGATGACAGCGTGGG	LRP1B	ENSG00000168702	0.693274311756308	[58]	[287]	6	hSpCas9	negative selection	12387565
141013697	141013720	2	+	28162770	OCIAML3	viability	GATGCGACAGTCCGAAAGGGTGG	LRP1B	ENSG00000168702	1.405992359675837	[14]	[119]	9	hSpCas9	negative selection	12387566
141013611	141013634	2	-	28162770	OCIAML3	viability	CAAGTGAGGTGACATTGCTGAGG	LRP1B	ENSG00000168702	1.1967643975378368	[24]	[172]	8	hSpCas9	negative selection	12387567
140989593	140989616	2	-	28162770	OCIAML3	viability	ATCGCTGCATCCCCAAGAGATGG	LRP1B	ENSG00000168702	0.33199177823205994	[49]	[189]	3	hSpCas9	negative selection	12387568
140923082	140923105	2	+	28162770	OCIAML3	viability	GAACGCAATTACCATCAGGGTGG	LRP1B	ENSG00000168702	-0.11517349046435033	[46]	[130]	-1	hSpCas9	negative selection	12387569