Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:4040
• Symbol:LRP6
• Description:LDL receptor related protein 6

DataSource: http://genomecrispr.dkfz.de/#!/results/LRP6

Export (tab separated) Export to Excel

Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
12158892	12158915	12	+	26472758	Jiyoye	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	-0.868459061107554	[45]	[18]	-6	hSpCas9	negative selection	92409
12158892	12158915	CHR_HG1362_PATCH	+	26472758	Jiyoye	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000281324	-0.868459061107554	[45]	[18]	-6	hSpCas9	negative selection	92410
12266706	12266729	12	+	26472758	Jiyoye	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	0.585173683483868	[98]	[111]	4	hSpCas9	negative selection	92411
12266706	12266729	CHR_HG1362_PATCH	+	26472758	Jiyoye	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000281324	0.585173683483868	[98]	[111]	4	hSpCas9	negative selection	92412
12181052	12181075	12	+	26472758	Jiyoye	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	-0.03504694709920065	[124]	[91]	0	hSpCas9	negative selection	92413
12181052	12181075	CHR_HG1362_PATCH	+	26472758	Jiyoye	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000281324	-0.03504694709920065	[124]	[91]	0	hSpCas9	negative selection	92414
12181031	12181054	CHR_HG1362_PATCH	+	26472758	Jiyoye	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000281324	-0.0014832052102655702	[676]	[509]	0	hSpCas9	negative selection	92415
12181031	12181054	12	+	26472758	Jiyoye	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	-0.0014832052102655702	[676]	[509]	0	hSpCas9	negative selection	92416
12164476	12164499	12	+	26472758	Jiyoye	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	2.1143936322780275	[97]	[319]	9	hSpCas9	negative selection	92417
12164476	12164499	CHR_HG1362_PATCH	+	26472758	Jiyoye	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000281324	2.1143936322780275	[97]	[319]	9	hSpCas9	negative selection	92418
12164431	12164454	CHR_HG1362_PATCH	-	26472758	Jiyoye	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000281324	1.2349944061231932	[79]	[141]	7	hSpCas9	negative selection	92419
12164431	12164454	12	-	26472758	Jiyoye	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	1.2349944061231932	[79]	[141]	7	hSpCas9	negative selection	92420
12159938	12159961	CHR_HG1362_PATCH	-	26472758	Jiyoye	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000281324	0.15236148247704817	[209]	[175]	1	hSpCas9	negative selection	92421
12159938	12159961	12	-	26472758	Jiyoye	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	0.15236148247704817	[209]	[175]	1	hSpCas9	negative selection	92422
12159032	12159055	CHR_HG1362_PATCH	-	26472758	Jiyoye	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000281324	0.4071753815058734	[50]	[50]	3	hSpCas9	negative selection	92423
12159032	12159055	12	-	26472758	Jiyoye	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	0.4071753815058734	[50]	[50]	3	hSpCas9	negative selection	92424
12150919	12150942	12	+	26472758	Jiyoye	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-1.7252749145177764	[56]	[12]	-8	hSpCas9	negative selection	92425
12150919	12150942	CHR_HG1362_PATCH	+	26472758	Jiyoye	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000281324	-1.7252749145177764	[56]	[12]	-8	hSpCas9	negative selection	92426
12124631	12124654	12	+	26472758	Jiyoye	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	-0.030510856718170498	[106]	[78]	0	hSpCas9	negative selection	92427
12124631	12124654	CHR_HG1362_PATCH	+	26472758	Jiyoye	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000281324	-0.030510856718170498	[106]	[78]	0	hSpCas9	negative selection	92428
12158892	12158915	12	+	26472758	KBM7	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	0.7056951129048029	[170,134]	[78,149]	7	hSpCas9	negative selection	283527
12158892	12158915	CHR_HG1362_PATCH	+	26472758	KBM7	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000281324	0.7056951129048029	[170,134]	[78,149]	7	hSpCas9	negative selection	283528
12266706	12266729	12	+	26472758	KBM7	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	-0.9675657472092682	[471,319]	[87,98]	-6	hSpCas9	negative selection	283529
12266706	12266729	CHR_HG1362_PATCH	+	26472758	KBM7	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000281324	-0.9675657472092682	[471,319]	[87,98]	-6	hSpCas9	negative selection	283530
12181052	12181075	12	+	26472758	KBM7	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	0.3836136760270995	[415,173]	[112,228]	4	hSpCas9	negative selection	283531
12181052	12181075	CHR_HG1362_PATCH	+	26472758	KBM7	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000281324	0.3836136760270995	[415,173]	[112,228]	4	hSpCas9	negative selection	283532
12181031	12181054	CHR_HG1362_PATCH	+	26472758	KBM7	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000281324	-0.04037962526433736	[1832,1467]	[961,559]	0	hSpCas9	negative selection	283533
12181031	12181054	12	+	26472758	KBM7	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	-0.04037962526433736	[1832,1467]	[961,559]	0	hSpCas9	negative selection	283534
12164476	12164499	12	+	26472758	KBM7	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.4733894220436492	[806,810]	[675,400]	5	hSpCas9	negative selection	283535
12164476	12164499	CHR_HG1362_PATCH	+	26472758	KBM7	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000281324	0.4733894220436492	[806,810]	[675,400]	5	hSpCas9	negative selection	283536
12164431	12164454	CHR_HG1362_PATCH	-	26472758	KBM7	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000281324	-0.3554634706284066	[653,403]	[215,167]	-3	hSpCas9	negative selection	283537
12164431	12164454	12	-	26472758	KBM7	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	-0.3554634706284066	[653,403]	[215,167]	-3	hSpCas9	negative selection	283538
12159938	12159961	CHR_HG1362_PATCH	-	26472758	KBM7	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000281324	0.5026106954817917	[1001,1060]	[739,649]	5	hSpCas9	negative selection	283539
12159938	12159961	12	-	26472758	KBM7	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	0.5026106954817917	[1001,1060]	[739,649]	5	hSpCas9	negative selection	283540
12159032	12159055	CHR_HG1362_PATCH	-	26472758	KBM7	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000281324	0.32224804220669073	[266,268]	[122,189]	3	hSpCas9	negative selection	283541
12159032	12159055	12	-	26472758	KBM7	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	0.32224804220669073	[266,268]	[122,189]	3	hSpCas9	negative selection	283542
12150919	12150942	12	+	26472758	KBM7	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	0.24115208969226254	[96,90]	[83,23]	2	hSpCas9	negative selection	283543
12150919	12150942	CHR_HG1362_PATCH	+	26472758	KBM7	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000281324	0.24115208969226254	[96,90]	[83,23]	2	hSpCas9	negative selection	283544
12124631	12124654	12	+	26472758	KBM7	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	0.2388383689099144	[361,462]	[263,204]	2	hSpCas9	negative selection	283545
12124631	12124654	CHR_HG1362_PATCH	+	26472758	KBM7	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000281324	0.2388383689099144	[361,462]	[263,204]	2	hSpCas9	negative selection	283546
12158892	12158915	12	+	26472758	Raji	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	-0.16945666998522446	[62]	[12]	-1	hSpCas9	negative selection	474645
12158892	12158915	CHR_HG1362_PATCH	+	26472758	Raji	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000281324	-0.16945666998522446	[62]	[12]	-1	hSpCas9	negative selection	474646
12266706	12266729	12	+	26472758	Raji	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	-0.08024346780217181	[245]	[53]	0	hSpCas9	negative selection	474647
12266706	12266729	CHR_HG1362_PATCH	+	26472758	Raji	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000281324	-0.08024346780217181	[245]	[53]	0	hSpCas9	negative selection	474648
12181052	12181075	12	+	26472758	Raji	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	0.7649913379265214	[141]	[55]	7	hSpCas9	negative selection	474649
12181052	12181075	CHR_HG1362_PATCH	+	26472758	Raji	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000281324	0.7649913379265214	[141]	[55]	7	hSpCas9	negative selection	474650
12181031	12181054	CHR_HG1362_PATCH	+	26472758	Raji	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000281324	1.0204754701504346	[649]	[305]	8	hSpCas9	negative selection	474651
12181031	12181054	12	+	26472758	Raji	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	1.0204754701504346	[649]	[305]	8	hSpCas9	negative selection	474652
12164476	12164499	12	+	26472758	Raji	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.5224210346524433	[332]	[110]	5	hSpCas9	negative selection	474653
12164476	12164499	CHR_HG1362_PATCH	+	26472758	Raji	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000281324	0.5224210346524433	[332]	[110]	5	hSpCas9	negative selection	474654
12164431	12164454	CHR_HG1362_PATCH	-	26472758	Raji	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000281324	0.4778554822189989	[262]	[84]	4	hSpCas9	negative selection	474655
12164431	12164454	12	-	26472758	Raji	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	0.4778554822189989	[262]	[84]	4	hSpCas9	negative selection	474656
12159938	12159961	CHR_HG1362_PATCH	-	26472758	Raji	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000281324	0.3026398267725332	[551]	[157]	3	hSpCas9	negative selection	474657
12159938	12159961	12	-	26472758	Raji	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	0.3026398267725332	[551]	[157]	3	hSpCas9	negative selection	474658
12159032	12159055	CHR_HG1362_PATCH	-	26472758	Raji	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000281324	0.4966579385873615	[112]	[36]	5	hSpCas9	negative selection	474659
12159032	12159055	12	-	26472758	Raji	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	0.4966579385873615	[112]	[36]	5	hSpCas9	negative selection	474660
12150919	12150942	12	+	26472758	Raji	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-0.10762935559725095	[64]	[13]	-1	hSpCas9	negative selection	474661
12150919	12150942	CHR_HG1362_PATCH	+	26472758	Raji	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000281324	-0.10762935559725095	[64]	[13]	-1	hSpCas9	negative selection	474662
12124631	12124654	12	+	26472758	Raji	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	-0.9196847078245711	[268]	[32]	-6	hSpCas9	negative selection	474663
12124631	12124654	CHR_HG1362_PATCH	+	26472758	Raji	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000281324	-0.9196847078245711	[268]	[32]	-6	hSpCas9	negative selection	474664
12158892	12158915	12	+	26472758	K562	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	-0.24386775364303537	[100]	[71]	-2	hSpCas9	negative selection	665763
12158892	12158915	CHR_HG1362_PATCH	+	26472758	K562	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000281324	-0.24386775364303537	[100]	[71]	-2	hSpCas9	negative selection	665764
12266706	12266729	12	+	26472758	K562	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	-0.387849487833066	[309]	[199]	-3	hSpCas9	negative selection	665765
12266706	12266729	CHR_HG1362_PATCH	+	26472758	K562	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000281324	-0.387849487833066	[309]	[199]	-3	hSpCas9	negative selection	665766
12181052	12181075	12	+	26472758	K562	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	1.0059699601109262	[255]	[433]	8	hSpCas9	negative selection	665767
12181052	12181075	CHR_HG1362_PATCH	+	26472758	K562	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000281324	1.0059699601109262	[255]	[433]	8	hSpCas9	negative selection	665768
12181031	12181054	CHR_HG1362_PATCH	+	26472758	K562	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000281324	0.7063938688603879	[1390]	[1915]	6	hSpCas9	negative selection	665769
12181031	12181054	12	+	26472758	K562	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	0.7063938688603879	[1390]	[1915]	6	hSpCas9	negative selection	665770
12164476	12164499	12	+	26472758	K562	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.25494939515861637	[545]	[549]	2	hSpCas9	negative selection	665771
12164476	12164499	CHR_HG1362_PATCH	+	26472758	K562	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000281324	0.25494939515861637	[545]	[549]	2	hSpCas9	negative selection	665772
12164431	12164454	CHR_HG1362_PATCH	-	26472758	K562	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000281324	0.25519856641968963	[399]	[402]	2	hSpCas9	negative selection	665773
12164431	12164454	12	-	26472758	K562	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	0.25519856641968963	[399]	[402]	2	hSpCas9	negative selection	665774
12159938	12159961	CHR_HG1362_PATCH	-	26472758	K562	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000281324	0.06229436241188524	[1053]	[928]	0	hSpCas9	negative selection	665775
12159938	12159961	12	-	26472758	K562	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	0.06229436241188524	[1053]	[928]	0	hSpCas9	negative selection	665776
12159032	12159055	CHR_HG1362_PATCH	-	26472758	K562	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000281324	-0.2150128909708504	[241]	[175]	-1	hSpCas9	negative selection	665777
12159032	12159055	12	-	26472758	K562	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	-0.2150128909708504	[241]	[175]	-1	hSpCas9	negative selection	665778
12150919	12150942	12	+	26472758	K562	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	0.29886651168882317	[51]	[53]	2	hSpCas9	negative selection	665779
12150919	12150942	CHR_HG1362_PATCH	+	26472758	K562	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000281324	0.29886651168882317	[51]	[53]	2	hSpCas9	negative selection	665780
12124631	12124654	12	+	26472758	K562	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	-0.6427614419992481	[417]	[225]	-4	hSpCas9	negative selection	665781
12124631	12124654	CHR_HG1362_PATCH	+	26472758	K562	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000281324	-0.6427614419992481	[417]	[225]	-4	hSpCas9	negative selection	665782
12150919	12150942	12	+	26627737	DLD1	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	0.2989044822944157	[503]	[150,363,89]	3	hSpCas9	negative selection	782722
12158849	12158872	12	+	26627737	DLD1	viability	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	0.050413934532459015	[277]	[117,50,97]	0	hSpCas9	negative selection	782728
12162193	12162216	12	-	26627737	DLD1	viability	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-0.41671213290639686	[317]	[76,75,70]	-4	hSpCas9	negative selection	782729
12164476	12164499	12	+	26627737	DLD1	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	-0.6383907626588976	[998]	[237,125,229]	-6	hSpCas9	negative selection	782730
12181030	12181053	12	+	26627737	DLD1	viability	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	0.29007155068815116	[590]	[168,335,183]	3	hSpCas9	negative selection	782750
12186933	12186956	12	-	26627737	DLD1	viability	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.10418788807754276	[606]	[240,146,218]	1	hSpCas9	negative selection	782756
12150919	12150942	12	+	26627737	GBM cells	viability after 5 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-0.4893567148303728	[88]	[40,26]	-6	hSpCas9	negative selection	865037
12158849	12158872	12	+	26627737	GBM cells	viability after 5 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	-0.33594985825694734	[212]	[99,80]	-5	hSpCas9	negative selection	865043
12162193	12162216	12	-	26627737	GBM cells	viability after 5 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-0.5750173134467267	[99]	[52,18]	-7	hSpCas9	negative selection	865044
12164476	12164499	12	+	26627737	GBM cells	viability after 5 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.16956146482935452	[314]	[218,160]	2	hSpCas9	negative selection	865045
12181030	12181053	12	+	26627737	GBM cells	viability after 5 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	0.3602020052202862	[352]	[223,261]	5	hSpCas9	negative selection	865065
12186933	12186956	12	-	26627737	GBM cells	viability after 5 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.3250747526362399	[322]	[211,221]	5	hSpCas9	negative selection	865071
12150919	12150942	12	+	26627737	GBM cells	viability after 13 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-0.5579417158647149	[88]	[50,17]	-6	hSpCas9	negative selection	947352
12158849	12158872	12	+	26627737	GBM cells	viability after 13 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	-0.3779461890304431	[212]	[94,83]	-4	hSpCas9	negative selection	947358
12162193	12162216	12	-	26627737	GBM cells	viability after 13 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-0.34539016945086587	[99]	[77,13]	-4	hSpCas9	negative selection	947359
12164476	12164499	12	+	26627737	GBM cells	viability after 13 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	-0.001363126518740987	[314]	[226,124]	0	hSpCas9	negative selection	947360
12181030	12181053	12	+	26627737	GBM cells	viability after 13 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	0.22356385836756043	[352]	[248,202]	3	hSpCas9	negative selection	947380
12186933	12186956	12	-	26627737	GBM cells	viability after 13 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.14043342457876312	[322]	[185,198]	1	hSpCas9	negative selection	947386
12150919	12150942	12	+	26627737	GBM cells	viability after 21 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-1.209302314951877	[88]	[22,18]	-7	hSpCas9	negative selection	1029667
12158849	12158872	12	+	26627737	GBM cells	viability after 21 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	-0.9740084620725958	[212]	[60,56]	-7	hSpCas9	negative selection	1029673
12162193	12162216	12	-	26627737	GBM cells	viability after 21 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-0.019162759445935595	[99]	[50,55]	0	hSpCas9	negative selection	1029674
12164476	12164499	12	+	26627737	GBM cells	viability after 21 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.16890695198329542	[314]	[194,189]	1	hSpCas9	negative selection	1029675
12181030	12181053	12	+	26627737	GBM cells	viability after 21 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	0.5385302057361051	[352]	[288,268]	5	hSpCas9	negative selection	1029695
12186933	12186956	12	-	26627737	GBM cells	viability after 21 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.8796376369148391	[322]	[325,319]	8	hSpCas9	negative selection	1029701
12150919	12150942	12	+	26627737	RPE1	viability after 9 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-2.521065426552383	[1888]	[54,164]	-9	hSpCas9	negative selection	1111982
12158849	12158872	12	+	26627737	RPE1	viability after 9 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	-2.128110886769173	[683]	[72,17]	-9	hSpCas9	negative selection	1111988
12162193	12162216	12	-	26627737	RPE1	viability after 9 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-1.4678743200304294	[195]	[19,24]	-8	hSpCas9	negative selection	1111989
12164476	12164499	12	+	26627737	RPE1	viability after 9 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.45342350983582186	[769]	[216,475]	3	hSpCas9	negative selection	1111990
12181030	12181053	12	+	26627737	RPE1	viability after 9 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	-0.012018227030145212	[1194]	[315,441]	0	hSpCas9	negative selection	1112010
12186933	12186956	12	-	26627737	RPE1	viability after 9 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	-0.3402076936025793	[923]	[200,263]	-2	hSpCas9	negative selection	1112016
12150919	12150942	12	+	26627737	RPE1	viability after 12 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-2.224794888441888	[1888]	[76,141]	-8	hSpCas9	negative selection	1194297
12158849	12158872	12	+	26627737	RPE1	viability after 12 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	-1.6039002080437006	[683]	[109,7]	-8	hSpCas9	negative selection	1194303
12162193	12162216	12	-	26627737	RPE1	viability after 12 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-0.6070901172250798	[195]	[36,31]	-4	hSpCas9	negative selection	1194304
12164476	12164499	12	+	26627737	RPE1	viability after 12 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.0904417718330033	[769]	[109,336]	0	hSpCas9	negative selection	1194305
12181030	12181053	12	+	26627737	RPE1	viability after 12 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	0.15954818678603933	[1194]	[276,444]	1	hSpCas9	negative selection	1194325
12186933	12186956	12	-	26627737	RPE1	viability after 12 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.06403251812123706	[923]	[225,294]	0	hSpCas9	negative selection	1194331
12150919	12150942	12	+	26627737	RPE1	viability after 15 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-2.342726248726774	[1888]	[57,150]	-8	hSpCas9	negative selection	1276612
12158849	12158872	12	+	26627737	RPE1	viability after 15 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	-2.4009235292132804	[683]	[28,43]	-8	hSpCas9	negative selection	1276618
12162193	12162216	12	-	26627737	RPE1	viability after 15 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-0.2786530230859432	[195]	[5,83]	-2	hSpCas9	negative selection	1276619
12164476	12164499	12	+	26627737	RPE1	viability after 15 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	-0.47678007377076925	[769]	[42,265]	-3	hSpCas9	negative selection	1276620
12181030	12181053	12	+	26627737	RPE1	viability after 15 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	0.2894971592399541	[1194]	[319,502]	2	hSpCas9	negative selection	1276640
12186933	12186956	12	-	26627737	RPE1	viability after 15 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.20157941299082355	[923]	[436,168]	1	hSpCas9	negative selection	1276646
12150919	12150942	12	+	26627737	RPE1	viability after 18 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-1.8558856042438747	[1888]	[135,145]	-8	hSpCas9	negative selection	1358927
12158849	12158872	12	+	26627737	RPE1	viability after 18 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	-4.245062977174146	[683]	[1,17]	-9	hSpCas9	negative selection	1358933
12162193	12162216	12	-	26627737	RPE1	viability after 18 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-0.5825352284002006	[195]	[0,71]	-4	hSpCas9	negative selection	1358934
12164476	12164499	12	+	26627737	RPE1	viability after 18 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.11725486074809884	[769]	[163,290]	0	hSpCas9	negative selection	1358935
12181030	12181053	12	+	26627737	RPE1	viability after 18 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	0.13507753997826544	[1194]	[270,442]	0	hSpCas9	negative selection	1358955
12186933	12186956	12	-	26627737	RPE1	viability after 18 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.5064129732456066	[923]	[345,362]	3	hSpCas9	negative selection	1358961
12150919	12150942	12	+	26627737	HeLa	viability after 8 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	1.6899466894354307	[47]	[100,17,88]	9	hSpCas9	negative selection	1441242
12158849	12158872	12	+	26627737	HeLa	viability after 8 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	1.4789596232260018	[124]	[155,150,148]	9	hSpCas9	negative selection	1441248
12162193	12162216	12	-	26627737	HeLa	viability after 8 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	0.6128135837794495	[171]	[227,79,63]	5	hSpCas9	negative selection	1441249
12164476	12164499	12	+	26627737	HeLa	viability after 8 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	-0.5874461835034418	[616]	[185,118,228]	-5	hSpCas9	negative selection	1441250
12181030	12181053	12	+	26627737	HeLa	viability after 8 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	0.32387742381158413	[552]	[482,283,184]	3	hSpCas9	negative selection	1441270
12186933	12186956	12	-	26627737	HeLa	viability after 8 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.6842308488273245	[408]	[330,297,241]	6	hSpCas9	negative selection	1441276
12150919	12150942	12	+	26627737	HeLa	viability after 12 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	2.6745037485248866	[47]	[117,132,127]	9	hSpCas9	negative selection	1523557
12158849	12158872	12	+	26627737	HeLa	viability after 12 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	1.4345216252380326	[124]	[169,127,122]	8	hSpCas9	negative selection	1523563
12162193	12162216	12	-	26627737	HeLa	viability after 12 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	0.9014950141845742	[171]	[219,74,111]	7	hSpCas9	negative selection	1523564
12164476	12164499	12	+	26627737	HeLa	viability after 12 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	-0.431790403090469	[616]	[164,154,249]	-4	hSpCas9	negative selection	1523565
12181030	12181053	12	+	26627737	HeLa	viability after 12 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	0.36404083093646755	[552]	[272,225,389]	3	hSpCas9	negative selection	1523585
12186933	12186956	12	-	26627737	HeLa	viability after 12 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.5251074876076305	[408]	[465,159,118]	4	hSpCas9	negative selection	1523591
12150919	12150942	12	+	26627737	HeLa	viability after 15 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	2.402834160570826	[47]	[128,133,41]	9	hSpCas9	negative selection	1605872
12158849	12158872	12	+	26627737	HeLa	viability after 15 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	1.4069552099735205	[124]	[142,50,216]	8	hSpCas9	negative selection	1605878
12162193	12162216	12	-	26627737	HeLa	viability after 15 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	0.8255544162033723	[171]	[96,134,141]	6	hSpCas9	negative selection	1605879
12164476	12164499	12	+	26627737	HeLa	viability after 15 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.18400849942839204	[616]	[124,243,505]	1	hSpCas9	negative selection	1605880
12181030	12181053	12	+	26627737	HeLa	viability after 15 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	0.2611446712197777	[552]	[265,266,276]	2	hSpCas9	negative selection	1605900
12186933	12186956	12	-	26627737	HeLa	viability after 15 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.7308775188039285	[408]	[243,253,335]	6	hSpCas9	negative selection	1605906
12150919	12150942	12	+	26627737	HeLa	viability after 18 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	2.3947793076717954	[47]	[86,108,41]	9	hSpCas9	negative selection	1688187
12158849	12158872	12	+	26627737	HeLa	viability after 18 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	1.3773481602582773	[124]	[93,37,216]	8	hSpCas9	negative selection	1688193
12162193	12162216	12	-	26627737	HeLa	viability after 18 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	0.8811843765041627	[171]	[67,119,141]	6	hSpCas9	negative selection	1688194
12164476	12164499	12	+	26627737	HeLa	viability after 18 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.21308050666886746	[616]	[87,210,505]	1	hSpCas9	negative selection	1688195
12181030	12181053	12	+	26627737	HeLa	viability after 18 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	0.2976701844250065	[552]	[183,230,276]	2	hSpCas9	negative selection	1688215
12186933	12186956	12	-	26627737	HeLa	viability after 18 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.7575472185432173	[408]	[165,219,335]	6	hSpCas9	negative selection	1688221
12150919	12150942	12	+	26627737	HCT116	viability after 6 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-2.2804633065675803	[260]	[1,11]	-8	hSpCas9	negative selection	1770502
12158849	12158872	12	+	26627737	HCT116	viability after 6 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	0.6652281488247102	[359]	[130,66]	3	hSpCas9	negative selection	1770508
12162193	12162216	12	-	26627737	HCT116	viability after 6 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	0.25176450515466375	[308]	[91,38]	1	hSpCas9	negative selection	1770509
12164476	12164499	12	+	26627737	HCT116	viability after 6 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	1.333461917311265	[1086]	[186,564]	7	hSpCas9	negative selection	1770510
12181030	12181053	12	+	26627737	HCT116	viability after 6 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	-0.04119648101109019	[898]	[166,120]	0	hSpCas9	negative selection	1770530
12186933	12186956	12	-	26627737	HCT116	viability after 6 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	-1.0680933823984682	[886]	[90,52]	-6	hSpCas9	negative selection	1770536
12150919	12150942	12	+	26627737	HCT116	viability after 8 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	3.9017650998261737	[4]	[63,22,36]	9	hSpCas9	negative selection	1852817
12158849	12158872	12	+	26627737	HCT116	viability after 8 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	0.9537664668475323	[143]	[186,65,207]	8	hSpCas9	negative selection	1852823
12162193	12162216	12	-	26627737	HCT116	viability after 8 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-0.6444696541831921	[213]	[52,104,67]	-7	hSpCas9	negative selection	1852824
12164476	12164499	12	+	26627737	HCT116	viability after 8 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	-0.15587188455996692	[528]	[225,272,284]	-2	hSpCas9	negative selection	1852825
12181030	12181053	12	+	26627737	HCT116	viability after 8 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	0.17298022097994192	[504]	[415,297,229]	2	hSpCas9	negative selection	1852845
12186933	12186956	12	-	26627737	HCT116	viability after 8 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.162986590177143	[412]	[339,261,164]	2	hSpCas9	negative selection	1852851
12150919	12150942	12	+	26627737	HCT116	viability after 9 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	0.5418433839855085	[260]	[15,168]	4	hSpCas9	negative selection	1935132
12158849	12158872	12	+	26627737	HCT116	viability after 9 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	1.1493100716246694	[359]	[110,293]	7	hSpCas9	negative selection	1935138
12162193	12162216	12	-	26627737	HCT116	viability after 9 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	1.085703082540826	[308]	[49,273]	7	hSpCas9	negative selection	1935139
12164476	12164499	12	+	26627737	HCT116	viability after 9 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.8269793280007524	[1086]	[348,645]	6	hSpCas9	negative selection	1935140
12181030	12181053	12	+	26627737	HCT116	viability after 9 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	-0.6487806190820504	[898]	[132,168]	-4	hSpCas9	negative selection	1935160
12186933	12186956	12	-	26627737	HCT116	viability after 9 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	-0.027188823595878264	[886]	[380,114]	0	hSpCas9	negative selection	1935166
12150919	12150942	12	+	26627737	HCT116	viability after 12 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	4.4656140811435066	[4]	[74,29,66]	9	hSpCas9	negative selection	2017447
12158849	12158872	12	+	26627737	HCT116	viability after 12 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	0.47038230517659174	[143]	[152,91,64]	4	hSpCas9	negative selection	2017453
12162193	12162216	12	-	26627737	HCT116	viability after 12 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-0.519565652827923	[213]	[88,101,43]	-5	hSpCas9	negative selection	2017454
12164476	12164499	12	+	26627737	HCT116	viability after 12 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.22216200241629835	[528]	[348,295,324]	2	hSpCas9	negative selection	2017455
12181030	12181053	12	+	26627737	HCT116	viability after 12 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	-0.19698319461683655	[504]	[272,234,182]	-2	hSpCas9	negative selection	2017475
12186933	12186956	12	-	26627737	HCT116	viability after 12 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.2202140994885452	[412]	[161,232,370]	2	hSpCas9	negative selection	2017481
12150919	12150942	12	+	26627737	HCT116	viability after 15 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	4.289148350419503	[4]	[56,94,16]	9	hSpCas9	negative selection	2099762
12158849	12158872	12	+	26627737	HCT116	viability after 15 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	1.6103674121778067	[143]	[212,228,309]	9	hSpCas9	negative selection	2099768
12162193	12162216	12	-	26627737	HCT116	viability after 15 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-0.31854205721210727	[213]	[70,97,122]	-3	hSpCas9	negative selection	2099769
12164476	12164499	12	+	26627737	HCT116	viability after 15 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.141207848618231	[528]	[229,398,362]	1	hSpCas9	negative selection	2099770
12181030	12181053	12	+	26627737	HCT116	viability after 15 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	-0.20577608778200485	[504]	[427,188,159]	-2	hSpCas9	negative selection	2099790
12186933	12186956	12	-	26627737	HCT116	viability after 15 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.2251508831645722	[412]	[220,335,267]	2	hSpCas9	negative selection	2099796
12150919	12150942	12	+	26627737	HCT116	viability after 18 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	4.3164823360736815	[4]	[87,35,19]	9	hSpCas9	negative selection	2182077
12158849	12158872	12	+	26627737	HCT116	viability after 18 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	0.4137833847831738	[143]	[45,130,98]	3	hSpCas9	negative selection	2182083
12162193	12162216	12	-	26627737	HCT116	viability after 18 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	0.11598378120361769	[213]	[118,60,161]	1	hSpCas9	negative selection	2182084
12164476	12164499	12	+	26627737	HCT116	viability after 18 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.7459209795915406	[528]	[428,528,316]	6	hSpCas9	negative selection	2182085
12181030	12181053	12	+	26627737	HCT116	viability after 18 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	-0.15591489403053915	[504]	[317,181,156]	-1	hSpCas9	negative selection	2182105
12186933	12186956	12	-	26627737	HCT116	viability after 18 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.4112540876251656	[412]	[312,190,298]	3	hSpCas9	negative selection	2182111
12244623	12244645	12	-	24717434	HeLa	essential genes for diphteria toxin toxicity	TTGCTTTATGCAAACAGACGGG	LRP6	ENSG00000070018	-0.10345892671211829	[2719,3021,2375]	[0,0,0]	0	hSpCas9	positive selection	2381091
12244611	12244635	12	-	24717434	HeLa	essential genes for diphteria toxin toxicity	CAAACAGACGGGACTTGCGATTGG	LRP6	ENSG00000070018	-0.6176644621793005	[4235,3775,3607]	[0,0,0]	-5	hSpCas9	positive selection	2381092
12244568	12244590	12	-	24717434	HeLa	essential genes for diphteria toxin toxicity	AGAATGCTACGATTGTAGTTGG	LRP6	ENSG00000070018	0.39508241206944467	[1979,1955,1813]	[0,0,0]	1	hSpCas9	positive selection	2381093
12244623	12244645	12	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	TTGCTTTATGCAAACAGACGGG	LRP6	ENSG00000070018	3.4807377274199442	[2719,3021,2375]	[0,33,0]	6	hSpCas9	positive selection	2382355
12244623	12244645	12	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	TTGCTTTATGCAAACAGACGGG	LRP6	ENSG00000070018	3.4807377274199442	[2719,3021,2375]	[0,33,0]	6	hSpCas9	positive selection	2382356
12244611	12244635	12	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	CAAACAGACGGGACTTGCGATTGG	LRP6	ENSG00000070018	-0.6179746583907715	[4235,3775,3607]	[0,0,0]	-6	hSpCas9	positive selection	2382357
12244611	12244635	12	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	CAAACAGACGGGACTTGCGATTGG	LRP6	ENSG00000070018	-0.6179746583907715	[4235,3775,3607]	[0,0,0]	-6	hSpCas9	positive selection	2382358
12244568	12244590	12	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	AGAATGCTACGATTGTAGTTGG	LRP6	ENSG00000070018	0.3947085126490948	[1979,1955,1813]	[0,0,0]	1	hSpCas9	positive selection	2382359
12244568	12244590	12	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	AGAATGCTACGATTGTAGTTGG	LRP6	ENSG00000070018	0.3947085126490948	[1979,1955,1813]	[0,0,0]	1	hSpCas9	positive selection	2382360
12248755	12248778	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCTTGAGCCACTGCGCCCAG	LRP6	ENSG00000281324	1.5878752533514864	[74,11]	[3,54]	6	dCas9-VP64	positive selection	2388853
12248755	12248778	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCTTGAGCCACTGCGCCCAG	LRP6	ENSG00000070018	1.5878752533514864	[74,11]	[3,54]	6	dCas9-VP64	positive selection	2388854
12188067	12188090	CHR_HG1362_PATCH	-	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCGCCCACCACCACGCCTGG	LRP6	ENSG00000281324	1.906510521561382	[74,11]	[56,10]	6	dCas9-VP64	positive selection	2400696
12188067	12188090	12	-	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCGCCCACCACCACGCCTGG	LRP6	ENSG00000070018	1.906510521561382	[74,11]	[56,10]	6	dCas9-VP64	positive selection	2400697
12248632	12248655	12	-	25494202	A375	resistance to PLX-4720 (puromycin)	CAAAAATTAGCTGGGCGTAGTGG	LRP6	ENSG00000070018	-0.9180937029961482	[133,53]	[15,3]	-5	dCas9-VP64	positive selection	2405016
12131308	12131331	CHR_HG1362_PATCH	-	25494202	A375	resistance to PLX-4720 (puromycin)	AGAGACCATCCTGGCTAACACGG	LRP6	ENSG00000281324	-1.1174807317499718	[30,74]	[4,4]	-6	dCas9-VP64	positive selection	2405367
12131308	12131331	12	-	25494202	A375	resistance to PLX-4720 (puromycin)	AGAGACCATCCTGGCTAACACGG	LRP6	ENSG00000070018	-1.1174807317499718	[30,74]	[4,4]	-6	dCas9-VP64	positive selection	2405368
12211223	12211246	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCAGCAGTTTGAGACCAGCCCGG	LRP6	ENSG00000281324	-2.729845497757659	[196,428]	[6,13]	-9	dCas9-VP64	positive selection	2412708
12211223	12211246	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	TCAGCAGTTTGAGACCAGCCCGG	LRP6	ENSG00000070018	-2.729845497757659	[196,428]	[6,13]	-9	dCas9-VP64	positive selection	2412709
12152371	12152394	12	-	25494202	A375	resistance to PLX-4720 (puromycin)	AATCGCTTGAACCTGGGAGGTGG	LRP6	ENSG00000070018	0.7552978455787054	[33,39]	[12,13]	3	dCas9-VP64	positive selection	2413302
12267005	12267028	CHR_HG1362_PATCH	-	25494202	A375	resistance to PLX-4720 (puromycin)	CGCGAGGCAGAGGCTGAATGAGG	LRP6	ENSG00000281324	0.7975549889306903	[59,14]	[20,5]	3	dCas9-VP64	positive selection	2430332
12267005	12267028	12	-	25494202	A375	resistance to PLX-4720 (puromycin)	CGCGAGGCAGAGGCTGAATGAGG	LRP6	ENSG00000070018	0.7975549889306903	[59,14]	[20,5]	3	dCas9-VP64	positive selection	2430333
12266977	12267000	12	-	25494202	A375	resistance to PLX-4720 (puromycin)	CGCGGGGGAAGCGGGGCGCCGGG	LRP6	ENSG00000070018	-0.21156507880828368	[18,14]	[1,3]	-1	dCas9-VP64	positive selection	2430334
12266977	12267000	CHR_HG1362_PATCH	-	25494202	A375	resistance to PLX-4720 (puromycin)	CGCGGGGGAAGCGGGGCGCCGGG	LRP6	ENSG00000281324	-0.21156507880828368	[18,14]	[1,3]	-1	dCas9-VP64	positive selection	2430335
12144975	12144998	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	ATGGGTGCAGCAAACCAACAGGG	LRP6	ENSG00000281324	-0.1947992804013987	[253,165]	[62,14]	-1	dCas9-VP64	positive selection	2447919
12144975	12144998	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	ATGGGTGCAGCAAACCAACAGGG	LRP6	ENSG00000070018	-0.1947992804013987	[253,165]	[62,14]	-1	dCas9-VP64	positive selection	2447920
12203673	12203696	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGAGAATCGCTTGAACCCGAG	LRP6	ENSG00000281324	-1.1949452889942442	[147,110]	[6,17]	-7	dCas9-VP64	positive selection	2450072
12203673	12203696	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGAGAATCGCTTGAACCCGAG	LRP6	ENSG00000070018	-1.1949452889942442	[147,110]	[6,17]	-7	dCas9-VP64	positive selection	2450073
12243649	12243672	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	CACCTGTAATCCCAGCACTTGGG	LRP6	ENSG00000281324	-0.7697329427055237	[305,492]	[31,71]	-4	dCas9-VP64	positive selection	2453170
12243649	12243672	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	CACCTGTAATCCCAGCACTTGGG	LRP6	ENSG00000070018	-0.7697329427055237	[305,492]	[31,71]	-4	dCas9-VP64	positive selection	2453171
12135932	12135955	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCTAGCACTTTGGGAGGCTGCGG	LRP6	ENSG00000281324	-1.3778645461156502	[16,23]	[1,0]	-7	dCas9-VP64	positive selection	2455477
12135932	12135955	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	CCTAGCACTTTGGGAGGCTGCGG	LRP6	ENSG00000070018	-1.3778645461156502	[16,23]	[1,0]	-7	dCas9-VP64	positive selection	2455478
12202388	12202411	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAAAAATTAGCCCGGTGTGATGG	LRP6	ENSG00000281324	1.0156722252330177	[129,43]	[61,12]	4	dCas9-VP64	positive selection	2456902
12202388	12202411	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAAAAATTAGCCCGGTGTGATGG	LRP6	ENSG00000070018	1.0156722252330177	[129,43]	[61,12]	4	dCas9-VP64	positive selection	2456903
12255779	12255802	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCTGGTCTCAAACTCCTAAG	LRP6	ENSG00000281324	1.754298476960665	[131,229]	[162,104]	6	dCas9-VP64	positive selection	2469856
12255779	12255802	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	CAGGCTGGTCTCAAACTCCTAAG	LRP6	ENSG00000070018	1.754298476960665	[131,229]	[162,104]	6	dCas9-VP64	positive selection	2469857
12251147	12251170	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGTCTTAAACTGCTGACCTCAAG	LRP6	ENSG00000281324	-0.8386694289261399	[340,71]	[38,8]	-5	dCas9-VP64	positive selection	2472448
12251147	12251170	12	+	25494202	A375	resistance to PLX-4720 (puromycin)	GGTCTTAAACTGCTGACCTCAAG	LRP6	ENSG00000070018	-0.8386694289261399	[340,71]	[38,8]	-5	dCas9-VP64	positive selection	2472449
12248755	12248778	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCTTGAGCCACTGCGCCCAG	LRP6	ENSG00000281324	0.16456713163057946	[58,38]	[18,15]	1	dCas9-VP64	positive selection	2484108
12248755	12248778	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCTTGAGCCACTGCGCCCAG	LRP6	ENSG00000070018	0.16456713163057946	[58,38]	[18,15]	1	dCas9-VP64	positive selection	2484109
12188067	12188090	CHR_HG1362_PATCH	-	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCGCCCACCACCACGCCTGG	LRP6	ENSG00000281324	1.1664475786686166	[321,97]	[88,216]	7	dCas9-VP64	positive selection	2495951
12188067	12188090	12	-	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCGCCCACCACCACGCCTGG	LRP6	ENSG00000070018	1.1664475786686166	[321,97]	[88,216]	7	dCas9-VP64	positive selection	2495952
12248632	12248655	12	-	25494202	A375	resistance to PLX-4720 (zeocin)	CAAAAATTAGCTGGGCGTAGTGG	LRP6	ENSG00000070018	0.01566490298595924	[8,84]	[11,17]	0	dCas9-VP64	positive selection	2500271
12131308	12131331	CHR_HG1362_PATCH	-	25494202	A375	resistance to PLX-4720 (zeocin)	AGAGACCATCCTGGCTAACACGG	LRP6	ENSG00000281324	-0.3866569806865121	[139,148]	[35,34]	-4	dCas9-VP64	positive selection	2500622
12131308	12131331	12	-	25494202	A375	resistance to PLX-4720 (zeocin)	AGAGACCATCCTGGCTAACACGG	LRP6	ENSG00000070018	-0.3866569806865121	[139,148]	[35,34]	-4	dCas9-VP64	positive selection	2500623
12211223	12211246	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCAGCAGTTTGAGACCAGCCCGG	LRP6	ENSG00000281324	-1.135721094933603	[195,105]	[22,20]	-9	dCas9-VP64	positive selection	2507963
12211223	12211246	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	TCAGCAGTTTGAGACCAGCCCGG	LRP6	ENSG00000070018	-1.135721094933603	[195,105]	[22,20]	-9	dCas9-VP64	positive selection	2507964
12152371	12152394	12	-	25494202	A375	resistance to PLX-4720 (zeocin)	AATCGCTTGAACCTGGGAGGTGG	LRP6	ENSG00000070018	1.0802526276452251	[21,53]	[11,38]	7	dCas9-VP64	positive selection	2508557
12267005	12267028	CHR_HG1362_PATCH	-	25494202	A375	resistance to PLX-4720 (zeocin)	CGCGAGGCAGAGGCTGAATGAGG	LRP6	ENSG00000281324	2.323445370561427	[75,180]	[404,26]	9	dCas9-VP64	positive selection	2525587
12267005	12267028	12	-	25494202	A375	resistance to PLX-4720 (zeocin)	CGCGAGGCAGAGGCTGAATGAGG	LRP6	ENSG00000070018	2.323445370561427	[75,180]	[404,26]	9	dCas9-VP64	positive selection	2525588
12266977	12267000	12	-	25494202	A375	resistance to PLX-4720 (zeocin)	CGCGGGGGAAGCGGGGCGCCGGG	LRP6	ENSG00000070018	-1.0661355107331043	[17,69]	[8,3]	-8	dCas9-VP64	positive selection	2525589
12266977	12267000	CHR_HG1362_PATCH	-	25494202	A375	resistance to PLX-4720 (zeocin)	CGCGGGGGAAGCGGGGCGCCGGG	LRP6	ENSG00000281324	-1.0661355107331043	[17,69]	[8,3]	-8	dCas9-VP64	positive selection	2525590
12144975	12144998	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	ATGGGTGCAGCAAACCAACAGGG	LRP6	ENSG00000281324	-0.16840569401957173	[64,29]	[17,8]	-2	dCas9-VP64	positive selection	2543174
12144975	12144998	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	ATGGGTGCAGCAAACCAACAGGG	LRP6	ENSG00000070018	-0.16840569401957173	[64,29]	[17,8]	-2	dCas9-VP64	positive selection	2543175
12203673	12203696	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGAGAATCGCTTGAACCCGAG	LRP6	ENSG00000281324	1.2597172262171965	[381,372]	[459,141]	7	dCas9-VP64	positive selection	2545327
12203673	12203696	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGAGAATCGCTTGAACCCGAG	LRP6	ENSG00000070018	1.2597172262171965	[381,372]	[459,141]	7	dCas9-VP64	positive selection	2545328
12243649	12243672	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	CACCTGTAATCCCAGCACTTGGG	LRP6	ENSG00000281324	-0.7960951384238878	[400,199]	[64,47]	-7	dCas9-VP64	positive selection	2548425
12243649	12243672	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	CACCTGTAATCCCAGCACTTGGG	LRP6	ENSG00000070018	-0.7960951384238878	[400,199]	[64,47]	-7	dCas9-VP64	positive selection	2548426
12135932	12135955	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCTAGCACTTTGGGAGGCTGCGG	LRP6	ENSG00000281324	-0.7460689547377737	[92,23]	[17,3]	-7	dCas9-VP64	positive selection	2550732
12135932	12135955	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	CCTAGCACTTTGGGAGGCTGCGG	LRP6	ENSG00000070018	-0.7460689547377737	[92,23]	[17,3]	-7	dCas9-VP64	positive selection	2550733
12202388	12202411	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAAAAATTAGCCCGGTGTGATGG	LRP6	ENSG00000281324	1.0172914386543983	[12,29]	[13,14]	6	dCas9-VP64	positive selection	2552157
12202388	12202411	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAAAAATTAGCCCGGTGTGATGG	LRP6	ENSG00000070018	1.0172914386543983	[12,29]	[13,14]	6	dCas9-VP64	positive selection	2552158
12255779	12255802	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCTGGTCTCAAACTCCTAAG	LRP6	ENSG00000281324	0.3544513964898359	[322,573]	[129,237]	3	dCas9-VP64	positive selection	2565111
12255779	12255802	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	CAGGCTGGTCTCAAACTCCTAAG	LRP6	ENSG00000070018	0.3544513964898359	[322,573]	[129,237]	3	dCas9-VP64	positive selection	2565112
12251147	12251170	CHR_HG1362_PATCH	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGTCTTAAACTGCTGACCTCAAG	LRP6	ENSG00000281324	-0.09189273539994539	[160,68]	[54,16]	0	dCas9-VP64	positive selection	2567703
12251147	12251170	12	+	25494202	A375	resistance to PLX-4720 (zeocin)	GGTCTTAAACTGCTGACCTCAAG	LRP6	ENSG00000070018	-0.09189273539994539	[160,68]	[54,16]	0	dCas9-VP64	positive selection	2567704
12164532	12164555	12	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CCCTGTGCTGAGGAAAACGGGGG	LRP6	ENSG00000070018	0.30553756214752525	[3,3]	[3,3]	6	hSpCas9	positive selection	3000012
12181053	12181076	12	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	0.24191304685685389	[2,2]	[4,1]	5	hSpCas9	positive selection	3000013
12244631	12244654	12	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTTTGCATAAAGCAACAAAGGGG	LRP6	ENSG00000070018	0.061519101676005085	[3,3]	[3,2]	1	hSpCas9	positive selection	3000014
12187109	12187132	12	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TTATGTTAATAGGCAGGCAGTGG	LRP6	ENSG00000070018	0.24218931529136456	[4,4]	[2,5]	5	hSpCas9	positive selection	3000015
12164532	12164555	12	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CCCTGTGCTGAGGAAAACGGGGG	LRP6	ENSG00000070018	-0.10678353644089035	[3,3]	[2,1]	-1	hSpCas9	positive selection	3067870
12181053	12181076	12	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	0.598205110359824	[2,2]	[2,3]	8	hSpCas9	positive selection	3067871
12244631	12244654	12	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTTTGCATAAAGCAACAAAGGGG	LRP6	ENSG00000070018	-0.08670025904460665	[3,3]	[3,1]	-1	hSpCas9	positive selection	3067872
12187109	12187132	12	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TTATGTTAATAGGCAGGCAGTGG	LRP6	ENSG00000070018	0.39722922073441697	[4,4]	[3,4]	7	hSpCas9	positive selection	3067873
12181244	12181267		-	24336571	A375	resistance to PLX after 7 days	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.45357137200852293	[5,3]	[7,5]	9	hSpCas9	positive selection	3125217
12181159	12181182		-	24336571	A375	resistance to PLX after 7 days	GGGTTGCACGAAATCTTTATTGG	LRP6	ENSG00000070018	-0.40491538527927906	[4,5]	[4,2]	-9	hSpCas9	positive selection	3125218
12184018	12184041		-	24336571	A375	resistance to PLX after 7 days	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.02158943597640306	[33,32]	[33,30]	0	hSpCas9	positive selection	3125219
12181244	12181267		-	24336571	A375	resistance to PLX after 14 days	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.9270641235602192	[4,9]	[5,5]	7	hSpCas9	positive selection	3183010
12181159	12181182		-	24336571	A375	resistance to PLX after 14 days	GGGTTGCACGAAATCTTTATTGG	LRP6	ENSG00000070018	0.02362878493901388	[4,7]	[1,2]	0	hSpCas9	positive selection	3183011
12184018	12184041		-	24336571	A375	resistance to PLX after 14 days	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.596225213170778	[28,35]	[9,8]	-7	hSpCas9	positive selection	3183012
12181244	12181267		-	24336571	A375	viability after 7 days	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	-0.45497509204671405	[6]	[5,3]	-6	hSpCas9	negative selection	3240803
12181159	12181182		-	24336571	A375	viability after 7 days	GGGTTGCACGAAATCTTTATTGG	LRP6	ENSG00000070018	-0.6950814783694661	[9]	[4,5]	-7	hSpCas9	negative selection	3240804
12184018	12184041		-	24336571	A375	viability after 7 days	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	0.37995138960018526	[26]	[33,32]	6	hSpCas9	negative selection	3240805
12181244	12181267		-	24336571	A375	viability after 14 days	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.03765850682380811	[6]	[4,9]	0	hSpCas9	negative selection	3298596
12181159	12181182		-	24336571	A375	viability after 14 days	GGGTTGCACGAAATCTTTATTGG	LRP6	ENSG00000070018	-0.5082286193825714	[9]	[4,7]	-6	hSpCas9	negative selection	3298597
12184018	12184041		-	24336571	A375	viability after 14 days	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	0.3623516550830904	[26]	[28,35]	4	hSpCas9	negative selection	3298598
12179926	12179949	12	-	27383988	293T	resistance to West Nile virus (flavivirus)	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	1.5430806937797126	[104,104]	[1,1]	6	hSpCas9	positive selection	3377584
12184018	12184041	12	-	27383988	293T	resistance to West Nile virus (flavivirus)	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-1.4008852713059596	[403,403]	[0,0]	-8	hSpCas9	positive selection	3377585
12184033	12184056	12	+	27383988	293T	resistance to West Nile virus (flavivirus)	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	0.47596649792117546	[109,109]	[0,0]	2	hSpCas9	positive selection	3377586
12164532	12164555	12	-	26780180	HT29	viability (Avana library 4 designs)	CCCTGTGCTGAGGAAAACGGGGG	LRP6	ENSG00000070018	0.0806329331760479	[]	[]	0	hSpCas9	negative selection	3437581
12181052	12181075	12	+	26780180	HT29	viability (Avana library 4 designs)	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	1.95442436516226	[]	[]	7	hSpCas9	negative selection	3437582
12244630	12244653	12	+	26780180	HT29	viability (Avana library 4 designs)	GTTTGCATAAAGCAACAAAGGGG	LRP6	ENSG00000070018	0.524754242119147	[]	[]	2	hSpCas9	negative selection	3437583
12187109	12187132	12	-	26780180	HT29	viability (Avana library 4 designs)	TTATGTTAATAGGCAGGCAGTGG	LRP6	ENSG00000070018	-0.210152897182289	[]	[]	-3	hSpCas9	negative selection	3437584
12244630	12244653	12	+	26780180	A375	viability (Avana lentiCRISPRv2)	GTTTGCATAAAGCAACAAAGGGG	LRP6	ENSG00000070018	-3.32033107056522	[]	[]	-4	hSpCas9	negative selection	3526373
12181052	12181075	12	+	26780180	A375	viability (Avana lentiCRISPRv2)	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	3.6374974142204	[]	[]	6	hSpCas9	negative selection	3526374
12164532	12164555	12	-	26780180	A375	viability (Avana lentiCRISPRv2)	CCCTGTGCTGAGGAAAACGGGGG	LRP6	ENSG00000070018	1.68096371129487	[]	[]	2	hSpCas9	negative selection	3526375
12187109	12187132	12	-	26780180	A375	viability (Avana lentiCRISPRv2)	TTATGTTAATAGGCAGGCAGTGG	LRP6	ENSG00000070018	-1.78849475941209	[]	[]	-2	hSpCas9	negative selection	3526376
12184081	12184104	12	+	26780180	A375	viability (Avana lentiCRISPRv2)	CCCCCATTGTCAATTCCACATGG	LRP6	ENSG00000070018	-0.796246263739114	[]	[]	-1	hSpCas9	negative selection	3526377
12159868	12159891	12	-	26780180	A375	viability (Avana lentiCRISPRv2)	CCTTAGTTCCAAATGTGGGGCGG	LRP6	ENSG00000070018	3.35646706927948	[]	[]	5	hSpCas9	negative selection	3526378
12244630	12244653	12	+	26780180	A375	viability (Avana lentiGuide)	GTTTGCATAAAGCAACAAAGGGG	LRP6	ENSG00000070018	-0.998769061260087	[]	[]	-1	hSpCas9	negative selection	3635032
12181052	12181075	12	+	26780180	A375	viability (Avana lentiGuide)	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	-5.53255258648288	[]	[]	-8	hSpCas9	negative selection	3635033
12164532	12164555	12	-	26780180	A375	viability (Avana lentiGuide)	CCCTGTGCTGAGGAAAACGGGGG	LRP6	ENSG00000070018	-5.48467075287357	[]	[]	-8	hSpCas9	negative selection	3635034
12187109	12187132	12	-	26780180	A375	viability (Avana lentiGuide)	TTATGTTAATAGGCAGGCAGTGG	LRP6	ENSG00000070018	-3.30651941328544	[]	[]	-6	hSpCas9	negative selection	3635035
12184081	12184104	12	+	26780180	A375	viability (Avana lentiGuide)	CCCCCATTGTCAATTCCACATGG	LRP6	ENSG00000070018	-5.68382431063087	[]	[]	-8	hSpCas9	negative selection	3635036
12159868	12159891	12	-	26780180	A375	viability (Avana lentiGuide)	CCTTAGTTCCAAATGTGGGGCGG	LRP6	ENSG00000070018	-2.51003538379185	[]	[]	-4	hSpCas9	negative selection	3635037
12244630	12244653	12	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTTTGCATAAAGCAACAAAGGGG	LRP6	ENSG00000070018	-0.4592969874384506	[5]	[3,3]	-6	hSpCas9	positive selection	3743691
12181052	12181075	12	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	0.16240895914741188	[4]	[4,5]	4	hSpCas9	positive selection	3743692
12164532	12164555	12	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCCTGTGCTGAGGAAAACGGGGG	LRP6	ENSG00000070018	-0.008913526072055866	[4]	[4,3]	0	hSpCas9	positive selection	3743693
12187109	12187132	12	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TTATGTTAATAGGCAGGCAGTGG	LRP6	ENSG00000070018	-0.1502746717804319	[7]	[5,6]	-2	hSpCas9	positive selection	3743694
12184081	12184104	12	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCCCCATTGTCAATTCCACATGG	LRP6	ENSG00000070018	0.2014162054358017	[4]	[5,4]	5	hSpCas9	positive selection	3743695
12159868	12159891	12	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CCTTAGTTCCAAATGTGGGGCGG	LRP6	ENSG00000070018	0.12970796352555078	[4]	[5,3]	3	hSpCas9	positive selection	3743696
12244630	12244653	12	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTTTGCATAAAGCAACAAAGGGG	LRP6	ENSG00000070018	0.31188379793468196	[5]	[6,4]	8	hSpCas9	positive selection	3852298
12181052	12181075	12	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	-0.5669987139275371	[4]	[2,1]	-6	hSpCas9	positive selection	3852299
12164532	12164555	12	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCCTGTGCTGAGGAAAACGGGGG	LRP6	ENSG00000070018	0.18819440467498208	[4]	[3,4]	4	hSpCas9	positive selection	3852300
12187109	12187132	12	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TTATGTTAATAGGCAGGCAGTGG	LRP6	ENSG00000070018	0.19524457938202194	[6]	[6,5]	5	hSpCas9	positive selection	3852301
12184081	12184104	12	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCCCCATTGTCAATTCCACATGG	LRP6	ENSG00000070018	0.3202760525911084	[5]	[6,6]	8	hSpCas9	positive selection	3852302
12159868	12159891	12	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CCTTAGTTCCAAATGTGGGGCGG	LRP6	ENSG00000070018	0.24660012790610697	[4]	[5,3]	6	hSpCas9	positive selection	3852303
12181244	12181267	12	-	26780180	A375	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.31711825619739	[]	[]	0	hSpCas9	negative selection	3957950
12184033	12184056	12	+	26780180	A375	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	1.02542814642314	[]	[]	5	hSpCas9	negative selection	3957951
12179926	12179949	12	-	26780180	A375	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	1.71294848122737	[]	[]	9	hSpCas9	negative selection	3957952
12184018	12184041	12	-	26780180	A375	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	2.0682587209882	[]	[]	9	hSpCas9	negative selection	3957953
12181305	12181328	12	-	26780180	A375	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.641182914338834	[]	[]	2	hSpCas9	negative selection	3957954
12179902	12179925	12	-	26780180	A375	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.17705637219399	[]	[]	0	hSpCas9	negative selection	3957955
12181244	12181267	12	-	26780180	HT29	viability (GeCKOv2 library)	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.422201036945206	[]	[]	1	hSpCas9	negative selection	4065916
12184033	12184056	12	+	26780180	HT29	viability (GeCKOv2 library)	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	1.21971275939785	[]	[]	6	hSpCas9	negative selection	4065917
12179926	12179949	12	-	26780180	HT29	viability (GeCKOv2 library)	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	1.79767752356199	[]	[]	8	hSpCas9	negative selection	4065918
12184018	12184041	12	-	26780180	HT29	viability (GeCKOv2 library)	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	1.39837912548879	[]	[]	7	hSpCas9	negative selection	4065919
12181305	12181328	12	-	26780180	HT29	viability (GeCKOv2 library)	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.00904946268871872	[]	[]	0	hSpCas9	negative selection	4065920
12179902	12179925	12	-	26780180	HT29	viability (GeCKOv2 library)	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.46776597966335	[]	[]	1	hSpCas9	negative selection	4065921
12181244	12181267	12	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.23632863571701623	[2]	[1,2]	6	hSpCas9	positive selection	4149338
12181159	12181182	12	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GGGTTGCACGAAATCTTTATTGG	LRP6	ENSG00000070018	0.19559397941618123	[2]	[2,1]	5	hSpCas9	positive selection	4149339
12184018	12184041	12	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	0.03263044009458049	[4]	[3,3]	0	hSpCas9	positive selection	4149340
12181244	12181267	12	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	-0.6161226925400838	[3]	[1,0,1,0]	-8	hSpCas9	positive selection	4213360
12181159	12181182	12	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GGGTTGCACGAAATCTTTATTGG	LRP6	ENSG00000070018	2.265718885433089	[0]	[3,0,0,2]	9	hSpCas9	positive selection	4213361
12184018	12184041	12	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	1.261825048260379	[3]	[3,2,2,5]	9	hSpCas9	positive selection	4213362
12181305	12181328	12	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.40254154929766456	[4]	[4,4]	7	hSpCas9	positive selection	4280889
12179902	12179925	12	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.1898645113995377	[4]	[4,3]	4	hSpCas9	positive selection	4280890
12181244	12181267	12	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	-0.011652483530947999	[3]	[4,1]	0	hSpCas9	positive selection	4280891
12179926	12179949	12	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.42532857398427115	[2]	[2,0]	-7	hSpCas9	positive selection	4345148
12184018	12184041	12	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.19408638510007248	[4]	[3,1]	-4	hSpCas9	positive selection	4345149
12184033	12184056	12	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.17124057061185854	[2]	[2,0]	-3	hSpCas9	positive selection	4345150
12162192	12162214	12	-	27760321	OCIAML3	viability	CGCGTTGGACCCTGCCGAAGGG	LRP6	ENSG00000070018	0.4816017838800165	[601,521]	[566,670]	6	hSpCas9	negative selection	4415164
12162269	12162291	12	-	27760321	OCIAML3	viability	CGAATTGAGGTGTCAAAGTTGG	LRP6	ENSG00000070018	-0.30141978014484594	[291,271]	[198,152]	-3	hSpCas9	negative selection	4415165
12181247	12181269	12	+	27760321	OCIAML3	viability	TCTATAAATGAACGGCGTATGG	LRP6	ENSG00000070018	0.24677547418073043	[127,109]	[67,164]	3	hSpCas9	negative selection	4415166
12181301	12181323	12	-	27760321	OCIAML3	viability	TAGATTACGATCCTGTGGAAGG	LRP6	ENSG00000070018	0.03077336142950171	[252,221]	[194,181]	0	hSpCas9	negative selection	4415167
12244410	12244432	12	-	27760321	OCIAML3	viability	TTATTGTCCCCCGATGGGCTGG	LRP6	ENSG00000070018	-0.44220335899786023	[579,472]	[225,399]	-4	hSpCas9	negative selection	4415168
12162192	12162214	12	-	27760321	OCIAML2	viability	CGCGTTGGACCCTGCCGAAGGG	LRP6	ENSG00000070018	0.06680701201484657	[601,521]	[354,632]	0	hSpCas9	negative selection	4498627
12162269	12162291	12	-	27760321	OCIAML2	viability	CGAATTGAGGTGTCAAAGTTGG	LRP6	ENSG00000070018	0.06945943904790641	[291,271]	[191,301]	0	hSpCas9	negative selection	4498628
12181247	12181269	12	+	27760321	OCIAML2	viability	TCTATAAATGAACGGCGTATGG	LRP6	ENSG00000070018	-0.5013305651781796	[127,109]	[53,85]	-5	hSpCas9	negative selection	4498629
12181301	12181323	12	-	27760321	OCIAML2	viability	TAGATTACGATCCTGTGGAAGG	LRP6	ENSG00000070018	-0.3044950995366428	[252,221]	[118,202]	-4	hSpCas9	negative selection	4498630
12244410	12244432	12	-	27760321	OCIAML2	viability	TTATTGTCCCCCGATGGGCTGG	LRP6	ENSG00000070018	-0.21313914335890666	[579,472]	[324,418]	-3	hSpCas9	negative selection	4498631
12162192	12162214	12	-	27760321	MV411	viability	CGCGTTGGACCCTGCCGAAGGG	LRP6	ENSG00000070018	0.5239426519044704	[601,521]	[644,361]	4	hSpCas9	negative selection	4582090
12162269	12162291	12	-	27760321	MV411	viability	CGAATTGAGGTGTCAAAGTTGG	LRP6	ENSG00000070018	-0.1048011996842867	[291,271]	[73,321]	-1	hSpCas9	negative selection	4582091
12181247	12181269	12	+	27760321	MV411	viability	TCTATAAATGAACGGCGTATGG	LRP6	ENSG00000070018	1.5754061537425823	[127,109]	[166,332]	9	hSpCas9	negative selection	4582092
12181301	12181323	12	-	27760321	MV411	viability	TAGATTACGATCCTGTGGAAGG	LRP6	ENSG00000070018	0.8015588532999268	[252,221]	[278,262]	6	hSpCas9	negative selection	4582093
12244410	12244432	12	-	27760321	MV411	viability	TTATTGTCCCCCGATGGGCTGG	LRP6	ENSG00000070018	-0.4165899763011852	[579,472]	[236,291]	-3	hSpCas9	negative selection	4582094
12162192	12162214	12	-	27760321	HL60	viability	CGCGTTGGACCCTGCCGAAGGG	LRP6	ENSG00000070018	0.02597632356194879	[601,521]	[506,422]	0	hSpCas9	negative selection	4665553
12162269	12162291	12	-	27760321	HL60	viability	CGAATTGAGGTGTCAAAGTTGG	LRP6	ENSG00000070018	0.7970079582703049	[291,271]	[396,403]	8	hSpCas9	negative selection	4665554
12181247	12181269	12	+	27760321	HL60	viability	TCTATAAATGAACGGCGTATGG	LRP6	ENSG00000070018	0.09962241892712154	[127,109]	[98,108]	1	hSpCas9	negative selection	4665555
12181301	12181323	12	-	27760321	HL60	viability	TAGATTACGATCCTGTGGAAGG	LRP6	ENSG00000070018	-1.5217313856203853	[252,221]	[64,69]	-8	hSpCas9	negative selection	4665556
12244410	12244432	12	-	27760321	HL60	viability	TTATTGTCCCCCGATGGGCTGG	LRP6	ENSG00000070018	-0.1623638577216242	[579,472]	[294,474]	-2	hSpCas9	negative selection	4665557
12162192	12162214	12	-	27760321	HT1080	viability	CGCGTTGGACCCTGCCGAAGGG	LRP6	ENSG00000070018	0.04102456702185625	[521,407]	[255,118]	0	hSpCas9	negative selection	4749016
12162269	12162291	12	-	27760321	HT1080	viability	CGAATTGAGGTGTCAAAGTTGG	LRP6	ENSG00000070018	-0.21026485229350522	[271,211]	[47,121]	-1	hSpCas9	negative selection	4749017
12181247	12181269	12	+	27760321	HT1080	viability	TCTATAAATGAACGGCGTATGG	LRP6	ENSG00000070018	-1.541686624789554	[109,85]	[0,26]	-5	hSpCas9	negative selection	4749018
12181301	12181323	12	-	27760321	HT1080	viability	TAGATTACGATCCTGTGGAAGG	LRP6	ENSG00000070018	0.9576260990595991	[221,172]	[200,99]	5	hSpCas9	negative selection	4749019
12244410	12244432	12	-	27760321	HT1080	viability	TTATTGTCCCCCGATGGGCTGG	LRP6	ENSG00000070018	0.04666582082548543	[472,368]	[198,144]	0	hSpCas9	negative selection	4749020
12162192	12162214	12	-	27760321	HT29	viability after 7 days	CGCGTTGGACCCTGCCGAAGGG	LRP6	ENSG00000070018	0.04117909492512711	[521,407]	[816,423,631]	0	hSpCas9	negative selection	4832479
12162269	12162291	12	-	27760321	HT29	viability after 7 days	CGAATTGAGGTGTCAAAGTTGG	LRP6	ENSG00000070018	-0.03527255359966819	[271,211]	[251,219,426]	0	hSpCas9	negative selection	4832480
12181247	12181269	12	+	27760321	HT29	viability after 7 days	TCTATAAATGAACGGCGTATGG	LRP6	ENSG00000070018	-0.5182923497874492	[109,85]	[147,87,37]	-6	hSpCas9	negative selection	4832481
12181301	12181323	12	-	27760321	HT29	viability after 7 days	TAGATTACGATCCTGTGGAAGG	LRP6	ENSG00000070018	-0.534959255047584	[221,172]	[372,47,133]	-7	hSpCas9	negative selection	4832482
12244410	12244432	12	-	27760321	HT29	viability after 7 days	TTATTGTCCCCCGATGGGCTGG	LRP6	ENSG00000070018	0.01672954542128513	[472,368]	[532,594,512]	0	hSpCas9	negative selection	4832483
12162192	12162214	12	-	27760321	HT29	viability after 25 days	CGCGTTGGACCCTGCCGAAGGG	LRP6	ENSG00000070018	0.4806482863241612	[521,407]	[941,673,577]	5	hSpCas9	negative selection	4915942
12162269	12162291	12	-	27760321	HT29	viability after 25 days	CGAATTGAGGTGTCAAAGTTGG	LRP6	ENSG00000070018	-0.018554250609191136	[271,211]	[162,419,238]	0	hSpCas9	negative selection	4915943
12181247	12181269	12	+	27760321	HT29	viability after 25 days	TCTATAAATGAACGGCGTATGG	LRP6	ENSG00000070018	-0.9333083893261198	[109,85]	[50,86,35]	-6	hSpCas9	negative selection	4915944
12181301	12181323	12	-	27760321	HT29	viability after 25 days	TAGATTACGATCCTGTGGAAGG	LRP6	ENSG00000070018	-0.22108312463184	[221,172]	[176,155,254]	-2	hSpCas9	negative selection	4915945
12244410	12244432	12	-	27760321	HT29	viability after 25 days	TTATTGTCCCCCGATGGGCTGG	LRP6	ENSG00000070018	-0.06256984563247073	[472,368]	[395,437,561]	0	hSpCas9	negative selection	4915946
12162192	12162214	12	-	27760321	HT29	viability after 22 days	CGCGTTGGACCCTGCCGAAGGG	LRP6	ENSG00000070018	0.5265206570657792	[521,407]	[1004,531,779]	6	hSpCas9	negative selection	4999405
12162269	12162291	12	-	27760321	HT29	viability after 22 days	CGAATTGAGGTGTCAAAGTTGG	LRP6	ENSG00000070018	0.4107414821357699	[271,211]	[245,398,474]	4	hSpCas9	negative selection	4999406
12181247	12181269	12	+	27760321	HT29	viability after 22 days	TCTATAAATGAACGGCGTATGG	LRP6	ENSG00000070018	-1.3845287065797616	[109,85]	[43,60,24]	-7	hSpCas9	negative selection	4999407
12181301	12181323	12	-	27760321	HT29	viability after 22 days	TAGATTACGATCCTGTGGAAGG	LRP6	ENSG00000070018	-0.13920512960894726	[221,172]	[126,295,200]	-1	hSpCas9	negative selection	4999408
12244410	12244432	12	-	27760321	HT29	viability after 22 days	TTATTGTCCCCCGATGGGCTGG	LRP6	ENSG00000070018	-0.29346747252713035	[472,368]	[292,410,490]	-3	hSpCas9	negative selection	4999409
12162192	12162214	12	-	27760321	HT29	viability after 19 days	CGCGTTGGACCCTGCCGAAGGG	LRP6	ENSG00000070018	0.1882849933224458	[521,407]	[1213,429,250]	1	hSpCas9	negative selection	5082868
12162269	12162291	12	-	27760321	HT29	viability after 19 days	CGAATTGAGGTGTCAAAGTTGG	LRP6	ENSG00000070018	-0.4160646016921069	[271,211]	[268,217,143]	-4	hSpCas9	negative selection	5082869
12181247	12181269	12	+	27760321	HT29	viability after 19 days	TCTATAAATGAACGGCGTATGG	LRP6	ENSG00000070018	-0.875764035111622	[109,85]	[109,34,43]	-6	hSpCas9	negative selection	5082870
12181301	12181323	12	-	27760321	HT29	viability after 19 days	TAGATTACGATCCTGTGGAAGG	LRP6	ENSG00000070018	-0.6790674536853994	[221,172]	[130,148,141]	-5	hSpCas9	negative selection	5082871
12244410	12244432	12	-	27760321	HT29	viability after 19 days	TTATTGTCCCCCGATGGGCTGG	LRP6	ENSG00000070018	-0.11769813395548254	[472,368]	[397,586,344]	-1	hSpCas9	negative selection	5082872
12162192	12162214	12	-	27760321	HT29	viability after 16 days	CGCGTTGGACCCTGCCGAAGGG	LRP6	ENSG00000070018	0.5248810222883928	[521,407]	[1235,431,631]	6	hSpCas9	negative selection	5166331
12162269	12162291	12	-	27760321	HT29	viability after 16 days	CGAATTGAGGTGTCAAAGTTGG	LRP6	ENSG00000070018	-0.018321926908574482	[271,211]	[197,471,119]	0	hSpCas9	negative selection	5166332
12181247	12181269	12	+	27760321	HT29	viability after 16 days	TCTATAAATGAACGGCGTATGG	LRP6	ENSG00000070018	-0.9394691885170425	[109,85]	[68,4,99]	-7	hSpCas9	negative selection	5166333
12181301	12181323	12	-	27760321	HT29	viability after 16 days	TAGATTACGATCCTGTGGAAGG	LRP6	ENSG00000070018	-0.2966441950849551	[221,172]	[307,53,192]	-3	hSpCas9	negative selection	5166334
12244410	12244432	12	-	27760321	HT29	viability after 16 days	TTATTGTCCCCCGATGGGCTGG	LRP6	ENSG00000070018	0.2204713587884879	[472,368]	[503,816,313]	2	hSpCas9	negative selection	5166335
12162192	12162214	12	-	27760321	HT29	viability after 13 days	CGCGTTGGACCCTGCCGAAGGG	LRP6	ENSG00000070018	0.4769356957982865	[521,407]	[911,604,735]	6	hSpCas9	negative selection	5249794
12162269	12162291	12	-	27760321	HT29	viability after 13 days	CGAATTGAGGTGTCAAAGTTGG	LRP6	ENSG00000070018	-0.03795943050832673	[271,211]	[230,292,294]	0	hSpCas9	negative selection	5249795
12181247	12181269	12	+	27760321	HT29	viability after 13 days	TCTATAAATGAACGGCGTATGG	LRP6	ENSG00000070018	-0.5502545866759021	[109,85]	[116,40,74]	-6	hSpCas9	negative selection	5249796
12181301	12181323	12	-	27760321	HT29	viability after 13 days	TAGATTACGATCCTGTGGAAGG	LRP6	ENSG00000070018	0.20853690529321534	[221,172]	[239,200,347]	2	hSpCas9	negative selection	5249797
12244410	12244432	12	-	27760321	HT29	viability after 13 days	TTATTGTCCCCCGATGGGCTGG	LRP6	ENSG00000070018	-0.03840770408502328	[472,368]	[472,535,420]	0	hSpCas9	negative selection	5249798
12162192	12162214	12	-	27760321	HT29	viability after 10 days	CGCGTTGGACCCTGCCGAAGGG	LRP6	ENSG00000070018	0.4234161444724976	[521,407]	[879,774,682]	6	hSpCas9	negative selection	5333257
12162269	12162291	12	-	27760321	HT29	viability after 10 days	CGAATTGAGGTGTCAAAGTTGG	LRP6	ENSG00000070018	0.14194548928579687	[271,211]	[312,421,268]	1	hSpCas9	negative selection	5333258
12181247	12181269	12	+	27760321	HT29	viability after 10 days	TCTATAAATGAACGGCGTATGG	LRP6	ENSG00000070018	-0.45819046340704994	[109,85]	[108,75,81]	-5	hSpCas9	negative selection	5333259
12181301	12181323	12	-	27760321	HT29	viability after 10 days	TAGATTACGATCCTGTGGAAGG	LRP6	ENSG00000070018	-0.074446910020038	[221,172]	[251,216,232]	-1	hSpCas9	negative selection	5333260
12244410	12244432	12	-	27760321	HT29	viability after 10 days	TTATTGTCCCCCGATGGGCTGG	LRP6	ENSG00000070018	-0.38259395586264283	[472,368]	[378,343,482]	-5	hSpCas9	negative selection	5333261
12162192	12162214	12	-	27760321	MOLM13	viability	CGCGTTGGACCCTGCCGAAGGG	LRP6	ENSG00000070018	0.36701833887229174	[601,521]	[664,188]	2	hSpCas9	negative selection	5416720
12162269	12162291	12	-	27760321	MOLM13	viability	CGAATTGAGGTGTCAAAGTTGG	LRP6	ENSG00000070018	1.2544413494043005	[291,271]	[174,553]	8	hSpCas9	negative selection	5416721
12181247	12181269	12	+	27760321	MOLM13	viability	TCTATAAATGAACGGCGTATGG	LRP6	ENSG00000070018	0.9479858493312353	[127,109]	[180,84]	6	hSpCas9	negative selection	5416722
12181301	12181323	12	-	27760321	MOLM13	viability	TAGATTACGATCCTGTGGAAGG	LRP6	ENSG00000070018	2.453436974308698	[252,221]	[726,736]	9	hSpCas9	negative selection	5416723
12244410	12244432	12	-	27760321	MOLM13	viability	TTATTGTCCCCCGATGGGCTGG	LRP6	ENSG00000070018	0.6349779614713026	[579,472]	[398,509]	4	hSpCas9	negative selection	5416724
12266765	12266788	12	+	27661255	K562	viability	GGCGAGGGGTGGCCAGAAGTGGG	LRP6	ENSG00000070018	0.22833649184657445	[940,940]	[818,932]	7	dCas9-KRAB	negative selection	5490905
12266905	12266928	12	-	27661255	K562	viability	GCCGAGCGGCGCGGTAGAGAGGG	LRP6	ENSG00000070018	0.4780252550501414	[111,188]	[173,158]	9	dCas9-KRAB	negative selection	5490906
12266945	12266968	12	-	27661255	K562	viability	GGCGGGATGGAAGCAGACGCTGG	LRP6	ENSG00000070018	0.055129223680401546	[678,709]	[637,522]	2	dCas9-KRAB	negative selection	5490907
12181305	12181328	12	-	27260156	BXPC3	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.12295849181601048	[1177]	[1362,1183,1417,1406]	2	hSpCas9	negative selection	5553349
12179902	12179925	12	-	27260156	BXPC3	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.09515205083305656	[1188]	[1163,1247,1554,1366]	2	hSpCas9	negative selection	5553350
12181244	12181267	12	-	27260156	BXPC3	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.036586119128194206	[952]	[882,902,1177,1158]	0	hSpCas9	negative selection	5553351
12179926	12179949	12	-	27260156	BXPC3	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.4190670471246706	[348]	[241,323,222,303]	-7	hSpCas9	negative selection	5617608
12184018	12184041	12	-	27260156	BXPC3	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.0026755274236063276	[1034]	[1035,1052,1057,1184]	0	hSpCas9	negative selection	5617609
12184033	12184056	12	+	27260156	BXPC3	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.039452645698845656	[277]	[278,257,358,229]	-1	hSpCas9	negative selection	5617610
12181305	12181328	12	-	27260156	A673	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.0420814446805311	[1177]	[1473,1309,1324,1735]	1	hSpCas9	negative selection	5674600
12179902	12179925	12	-	27260156	A673	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	-0.007216927757902392	[1188]	[1649,1309,1292,1458]	0	hSpCas9	negative selection	5674601
12181244	12181267	12	-	27260156	A673	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.10247599917822225	[952]	[1346,1368,1094,1104]	2	hSpCas9	negative selection	5674602
12179926	12179949	12	-	27260156	A673	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.3628453428380133	[348]	[341,292,349,319]	-7	hSpCas9	negative selection	5738859
12184018	12184041	12	-	27260156	A673	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.23968871265940506	[1034]	[1180,1022,1045,968]	-5	hSpCas9	negative selection	5738860
12184033	12184056	12	+	27260156	A673	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.15358398601356316	[277]	[317,236,304,345]	-4	hSpCas9	negative selection	5738861
12181305	12181328	12	-	27260156	A375	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.09502904712311189	[1177]	[1375,1706,1565,1278]	1	hSpCas9	negative selection	5795851
12179902	12179925	12	-	27260156	A375	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.07146187711471397	[1188]	[1614,1732,1353,1199]	1	hSpCas9	negative selection	5795852
12181244	12181267	12	-	27260156	A375	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.3511314139062951	[952]	[1417,1758,1540,1047]	5	hSpCas9	negative selection	5795853
12179926	12179949	12	-	27260156	A375	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.4042640588242563	[348]	[333,264,335,291]	-5	hSpCas9	negative selection	5860110
12184018	12184041	12	-	27260156	A375	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	0.0625379517342941	[1034]	[1408,1364,1299,1015]	0	hSpCas9	negative selection	5860111
12184033	12184056	12	+	27260156	A375	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	0.15363803310440938	[277]	[325,348,299,454]	2	hSpCas9	negative selection	5860112
12181305	12181328	12	-	27260156	COLO741	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	-0.0076902243264778125	[1177]	[1556,1619,1328]	0	hSpCas9	negative selection	5917102
12179902	12179925	12	-	27260156	COLO741	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	-0.02667221911009876	[1188]	[1732,1506,1267]	0	hSpCas9	negative selection	5917103
12181244	12181267	12	-	27260156	COLO741	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.2295894132948273	[952]	[1524,1544,1232]	5	hSpCas9	negative selection	5917104
12179926	12179949	12	-	27260156	COLO741	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.3032637510248192	[348]	[435,312,341]	-6	hSpCas9	negative selection	5981361
12184018	12184041	12	-	27260156	COLO741	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.07846619844552905	[1034]	[1423,1138,1208]	-2	hSpCas9	negative selection	5981362
12184033	12184056	12	+	27260156	COLO741	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.4932894095472722	[277]	[250,317,191]	-8	hSpCas9	negative selection	5981363
12181305	12181328	12	-	27260156	CAL120	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	-0.33488840473698644	[1177]	[1347,1163,1004]	-5	hSpCas9	negative selection	6038353
12179902	12179925	12	-	27260156	CAL120	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.030321544908852527	[1188]	[1446,1466,1606]	0	hSpCas9	negative selection	6038354
12181244	12181267	12	-	27260156	CAL120	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.17972319467037612	[952]	[1177,1914,918]	2	hSpCas9	negative selection	6038355
12179926	12179949	12	-	27260156	CAL120	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.5943228946581295	[348]	[370,306,198]	-7	hSpCas9	negative selection	6102612
12184018	12184041	12	-	27260156	CAL120	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.11584979204352108	[1034]	[1481,807,1316]	-2	hSpCas9	negative selection	6102613
12184033	12184056	12	+	27260156	CAL120	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	0.13292397665561184	[277]	[516,287,353]	2	hSpCas9	negative selection	6102614
12181305	12181328	12	-	27260156	CADOES1	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.11903526987906976	[1177]	[1191,908,1383,1276]	2	hSpCas9	negative selection	6159604
12179902	12179925	12	-	27260156	CADOES1	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	-0.2255217715720539	[1188]	[903,952,861,1068]	-4	hSpCas9	negative selection	6159605
12181244	12181267	12	-	27260156	CADOES1	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.31008865565461385	[952]	[1175,1078,1124,1011]	5	hSpCas9	negative selection	6159606
12179926	12179949	12	-	27260156	CADOES1	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.4573277988214073	[348]	[195,210,293,244]	-7	hSpCas9	negative selection	6223863
12184018	12184041	12	-	27260156	CADOES1	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.1587802624920709	[1034]	[955,805,946,734]	-3	hSpCas9	negative selection	6223864
12184033	12184056	12	+	27260156	CADOES1	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	0.05288932916814382	[277]	[287,244,264,274]	0	hSpCas9	negative selection	6223865
12181305	12181328	12	-	27260156	EWS502	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.1190272355519093	[1177]	[1365,1324,1350,1373]	2	hSpCas9	negative selection	6280855
12179902	12179925	12	-	27260156	EWS502	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	-0.03484687441957557	[1188]	[1066,1202,1293,1380]	0	hSpCas9	negative selection	6280856
12181244	12181267	12	-	27260156	EWS502	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.09803819331142516	[952]	[954,1040,1221,1120]	1	hSpCas9	negative selection	6280857
12179926	12179949	12	-	27260156	EWS502	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.5405762025771337	[348]	[159,327,303,230]	-7	hSpCas9	negative selection	6345114
12184018	12184041	12	-	27260156	EWS502	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.14045535528426212	[1034]	[971,1073,899,1028]	-3	hSpCas9	negative selection	6345115
12184033	12184056	12	+	27260156	EWS502	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	0.05713137323502915	[277]	[263,367,216,381]	1	hSpCas9	negative selection	6345116
12181305	12181328	12	-	27260156	EW8	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	-0.0603555553527273	[1177]	[1251,770,803,887]	-1	hSpCas9	negative selection	6402106
12179902	12179925	12	-	27260156	EW8	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.2006810023130905	[1188]	[997,1339,1093,985]	3	hSpCas9	negative selection	6402107
12181244	12181267	12	-	27260156	EW8	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.09331822767371234	[952]	[893,988,580,878]	1	hSpCas9	negative selection	6402108
12179926	12179949	12	-	27260156	EW8	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.4951968854618989	[348]	[206,193,180,223]	-7	hSpCas9	negative selection	6466365
12184018	12184041	12	-	27260156	EW8	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	0.07115081036483928	[1034]	[694,1656,521,692]	1	hSpCas9	negative selection	6466366
12184033	12184056	12	+	27260156	EW8	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.2936582178349896	[277]	[187,211,215,113]	-5	hSpCas9	negative selection	6466367
12181305	12181328	12	-	27260156	CORL105	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.1565360984692381	[1177]	[1469,1486,1748,1473]	3	hSpCas9	negative selection	6523357
12179902	12179925	12	-	27260156	CORL105	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	-0.06481046601843787	[1188]	[1271,1161,1592,1337]	-1	hSpCas9	negative selection	6523358
12181244	12181267	12	-	27260156	CORL105	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	-0.06756651188165719	[952]	[1195,931,1150,999]	-1	hSpCas9	negative selection	6523359
12179926	12179949	12	-	27260156	CORL105	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.46061872989932007	[348]	[296,266,415,226]	-7	hSpCas9	negative selection	6587616
12184018	12184041	12	-	27260156	CORL105	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.26285593646012995	[1034]	[995,828,1176,1065]	-5	hSpCas9	negative selection	6587617
12184033	12184056	12	+	27260156	CORL105	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.04925684820677967	[277]	[224,333,387,318]	-1	hSpCas9	negative selection	6587618
12181305	12181328	12	-	27260156	HS294T	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.46188994886265045	[1177]	[825,578,509,563]	6	hSpCas9	negative selection	6644608
12179902	12179925	12	-	27260156	HS294T	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.2625657221645783	[1188]	[509,524,462,742]	3	hSpCas9	negative selection	6644609
12181244	12181267	12	-	27260156	HS294T	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.3977013119985602	[952]	[425,615,385,518]	5	hSpCas9	negative selection	6644610
12179926	12179949	12	-	27260156	HS294T	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.6413259852253145	[348]	[129,45,74,92]	-7	hSpCas9	negative selection	6708867
12184018	12184041	12	-	27260156	HS294T	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.19498618186011107	[1034]	[293,354,440,304]	-3	hSpCas9	negative selection	6708868
12184033	12184056	12	+	27260156	HS294T	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.10025189601955375	[277]	[108,100,43,154]	-1	hSpCas9	negative selection	6708869
12181305	12181328	12	-	27260156	HCC44	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	-0.15345619469699745	[1177]	[1506,792,1317,1267]	-3	hSpCas9	negative selection	6765859
12179902	12179925	12	-	27260156	HCC44	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.19327039991368578	[1188]	[1719,1248,1896,1395]	3	hSpCas9	negative selection	6765860
12181244	12181267	12	-	27260156	HCC44	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.2979263459774084	[952]	[1440,915,1786,1294]	5	hSpCas9	negative selection	6765861
12179926	12179949	12	-	27260156	HCC44	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.592750957539037	[348]	[214,143,368,344]	-7	hSpCas9	negative selection	6830118
12184018	12184041	12	-	27260156	HCC44	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	0.1059601984443852	[1034]	[1516,842,1649,1171]	1	hSpCas9	negative selection	6830119
12184033	12184056	12	+	27260156	HCC44	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.049963446900098574	[277]	[216,213,436,369]	-1	hSpCas9	negative selection	6830120
12181305	12181328	12	-	27260156	G402	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.4003385157619197	[1177]	[1684,2166,2238,1494]	5	hSpCas9	negative selection	6887110
12179902	12179925	12	-	27260156	G402	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.2899643626510877	[1188]	[1054,1885,1301,2701]	3	hSpCas9	negative selection	6887111
12181244	12181267	12	-	27260156	G402	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.2895228466058637	[952]	[1300,1862,1337,1196]	3	hSpCas9	negative selection	6887112
12179926	12179949	12	-	27260156	G402	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.0325924518887154	[348]	[264,603,477,310]	0	hSpCas9	negative selection	6951369
12184018	12184041	12	-	27260156	G402	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.2602258274427399	[1034]	[994,1597,1186,484]	-3	hSpCas9	negative selection	6951370
12184033	12184056	12	+	27260156	G402	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	0.30857897225976727	[277]	[877,218,358,283]	4	hSpCas9	negative selection	6951371
12181305	12181328	12	-	27260156	L33	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.2809810690109331	[1177]	[1489,550,1018,1269]	6	hSpCas9	negative selection	7008361
12179902	12179925	12	-	27260156	L33	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.09801276838705775	[1188]	[1290,530,812,1209]	2	hSpCas9	negative selection	7008362
12181244	12181267	12	-	27260156	L33	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.12337927692401318	[952]	[1055,409,682,1008]	2	hSpCas9	negative selection	7008363
12179926	12179949	12	-	27260156	L33	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.5002843346205259	[348]	[294,107,156,177]	-8	hSpCas9	negative selection	7072620
12184018	12184041	12	-	27260156	L33	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.09847701545350596	[1034]	[827,418,555,1132]	-2	hSpCas9	negative selection	7072621
12184033	12184056	12	+	27260156	L33	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.29718208948537717	[277]	[263,90,124,218]	-6	hSpCas9	negative selection	7072622
12181305	12181328	12	-	27260156	K562	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.15656761139179998	[1177]	[1000,1083,772,1714]	2	hSpCas9	negative selection	7129612
12179902	12179925	12	-	27260156	K562	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.21955712299820473	[1188]	[1093,1234,1166,1383]	2	hSpCas9	negative selection	7129613
12181244	12181267	12	-	27260156	K562	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.24269061928492563	[952]	[909,1178,643,1238]	3	hSpCas9	negative selection	7129614
12179926	12179949	12	-	27260156	K562	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.583246248169928	[348]	[329,183,67,247]	-6	hSpCas9	negative selection	7193871
12184018	12184041	12	-	27260156	K562	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.36233314940672656	[1034]	[625,797,910,537]	-4	hSpCas9	negative selection	7193872
12184033	12184056	12	+	27260156	K562	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.4481786921015012	[277]	[128,227,203,161]	-5	hSpCas9	negative selection	7193873
12181305	12181328	12	-	27260156	HT29	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.09851963589540724	[1177]	[1713,1593,1696,1179]	2	hSpCas9	negative selection	7250863
12179902	12179925	12	-	27260156	HT29	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.1573985612933695	[1188]	[2029,1903,1482,1135]	3	hSpCas9	negative selection	7250864
12181244	12181267	12	-	27260156	HT29	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.14657671124523963	[952]	[1520,1394,1244,1019]	3	hSpCas9	negative selection	7250865
12179926	12179949	12	-	27260156	HT29	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.7502001755022664	[348]	[295,218,306,192]	-8	hSpCas9	negative selection	7315122
12184018	12184041	12	-	27260156	HT29	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.07510080209358128	[1034]	[1116,1205,1293,1151]	-1	hSpCas9	negative selection	7315123
12184033	12184056	12	+	27260156	HT29	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.16507577249230965	[277]	[391,279,337,209]	-3	hSpCas9	negative selection	7315124
12181305	12181328	12	-	27260156	MHHES1	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.008213488517618384	[1177]	[1342,1454,1416,1148]	0	hSpCas9	negative selection	7372114
12179902	12179925	12	-	27260156	MHHES1	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.03916422949019149	[1188]	[1228,1487,1466,1299]	0	hSpCas9	negative selection	7372115
12181244	12181267	12	-	27260156	MHHES1	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.13137697417654692	[952]	[1096,1269,1238,1089]	2	hSpCas9	negative selection	7372116
12179926	12179949	12	-	27260156	MHHES1	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.2426554806385185	[348]	[767,292,224,130]	-4	hSpCas9	negative selection	7436373
12184018	12184041	12	-	27260156	MHHES1	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.052729461672665234	[1034]	[1294,764,1293,1104]	-1	hSpCas9	negative selection	7436374
12184033	12184056	12	+	27260156	MHHES1	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.32937391251525794	[277]	[242,237,227,273]	-6	hSpCas9	negative selection	7436375
12181305	12181328	12	-	27260156	MEWO	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.09940285695173157	[1177]	[1647,1053,930]	2	hSpCas9	negative selection	7493365
12179902	12179925	12	-	27260156	MEWO	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.1684393200258114	[1188]	[1412,983,1385]	4	hSpCas9	negative selection	7493366
12181244	12181267	12	-	27260156	MEWO	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.10751156177100007	[952]	[985,1047,851]	2	hSpCas9	negative selection	7493367
12179926	12179949	12	-	27260156	MEWO	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.9832887917917413	[348]	[172,155,167]	-9	hSpCas9	negative selection	7557624
12184018	12184041	12	-	27260156	MEWO	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.10720414861366279	[1034]	[1176,806,766]	-2	hSpCas9	negative selection	7557625
12184033	12184056	12	+	27260156	MEWO	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.09326273147782738	[277]	[241,245,242]	-2	hSpCas9	negative selection	7557626
12181305	12181328	12	-	27260156	LNCAPCLONEFGC	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	-0.04235411785469623	[1177]	[1078,824,1343,954]	0	hSpCas9	negative selection	7614616
12179902	12179925	12	-	27260156	LNCAPCLONEFGC	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	-0.15877334071782245	[1188]	[944,793,1009,1127]	-3	hSpCas9	negative selection	7614617
12181244	12181267	12	-	27260156	LNCAPCLONEFGC	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.19481463074233973	[952]	[1107,899,905,1028]	3	hSpCas9	negative selection	7614618
12179926	12179949	12	-	27260156	LNCAPCLONEFGC	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.48669835415548646	[348]	[189,195,272,252]	-6	hSpCas9	negative selection	7678875
12184018	12184041	12	-	27260156	LNCAPCLONEFGC	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.3243555048121006	[1034]	[646,840,778,727]	-5	hSpCas9	negative selection	7678876
12184033	12184056	12	+	27260156	LNCAPCLONEFGC	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	0.05656467323983183	[277]	[207,207,409,247]	0	hSpCas9	negative selection	7678877
12181305	12181328	12	-	27260156	PANC0327	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.01459298969103795	[1177]	[1142,747,1180,1202]	0	hSpCas9	negative selection	7735867
12179902	12179925	12	-	27260156	PANC0327	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.14392917043990994	[1188]	[902,1402,926,1381]	2	hSpCas9	negative selection	7735868
12181244	12181267	12	-	27260156	PANC0327	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.018196154172918755	[952]	[808,709,913,1010]	0	hSpCas9	negative selection	7735869
12179926	12179949	12	-	27260156	PANC0327	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.46963676192416604	[348]	[179,184,301,229]	-6	hSpCas9	negative selection	7800126
12184018	12184041	12	-	27260156	PANC0327	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.1334464911324118	[1034]	[824,930,656,925]	-2	hSpCas9	negative selection	7800127
12184033	12184056	12	+	27260156	PANC0327	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	0.2792885693867696	[277]	[88,194,413,496]	4	hSpCas9	negative selection	7800128
12181305	12181328	12	-	27260156	NCIH2009	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.33029057114141724	[1177]	[2569,2304,1423]	4	hSpCas9	negative selection	7857118
12179902	12179925	12	-	27260156	NCIH2009	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.1962499126326014	[1188]	[2432,1645,1736]	2	hSpCas9	negative selection	7857119
12181244	12181267	12	-	27260156	NCIH2009	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.32985488033133903	[952]	[1900,1657,1503]	4	hSpCas9	negative selection	7857120
12179926	12179949	12	-	27260156	NCIH2009	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.539072922560613	[348]	[268,445,275]	-6	hSpCas9	negative selection	7921377
12184018	12184041	12	-	27260156	NCIH2009	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.21173638903562708	[1034]	[1359,1021,1387]	-3	hSpCas9	negative selection	7921378
12184033	12184056	12	+	27260156	NCIH2009	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	0.06460540682102867	[277]	[295,412,486]	0	hSpCas9	negative selection	7921379
12181305	12181328	12	-	27260156	NCIH1373	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.03440550617793248	[1177]	[1633,1162,1052,430]	0	hSpCas9	negative selection	7978369
12179902	12179925	12	-	27260156	NCIH1373	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	-0.2887640533595217	[1188]	[1407,638,1354,274]	-3	hSpCas9	negative selection	7978370
12181244	12181267	12	-	27260156	NCIH1373	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.5117886001167236	[952]	[1306,2006,1395,334]	5	hSpCas9	negative selection	7978371
12179926	12179949	12	-	27260156	NCIH1373	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	0.24578017087647708	[348]	[156,339,876,113]	2	hSpCas9	negative selection	8042628
12184018	12184041	12	-	27260156	NCIH1373	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.17425109958195772	[1034]	[1282,1134,916,206]	-2	hSpCas9	negative selection	8042629
12184033	12184056	12	+	27260156	NCIH1373	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	0.1291347364534552	[277]	[548,173,335,92]	1	hSpCas9	negative selection	8042630
12181305	12181328	12	-	27260156	PATU8902	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.20551334807280397	[1177]	[1449,1675,2445,1833]	2	hSpCas9	negative selection	8099620
12179902	12179925	12	-	27260156	PATU8902	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	-0.6417894799754923	[1188]	[1028,1186,1069,933]	-6	hSpCas9	negative selection	8099621
12181244	12181267	12	-	27260156	PATU8902	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	-0.3112617080107729	[952]	[1110,1376,577,1367]	-3	hSpCas9	negative selection	8099622
12179926	12179949	12	-	27260156	PATU8902	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.5705195613275529	[348]	[209,485,115,581]	-5	hSpCas9	negative selection	8163879
12184018	12184041	12	-	27260156	PATU8902	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	0.027950745001999566	[1034]	[1275,1260,963,2638]	0	hSpCas9	negative selection	8163880
12184033	12184056	12	+	27260156	PATU8902	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	0.7748823230884536	[277]	[712,614,586,759]	7	hSpCas9	negative selection	8163881
12181305	12181328	12	-	27260156	PANC1	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	-0.2421910040687798	[1177]	[896,912,914,716]	-4	hSpCas9	negative selection	8220871
12179902	12179925	12	-	27260156	PANC1	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.2854741686891924	[1188]	[1135,1835,1188,966]	4	hSpCas9	negative selection	8220872
12181244	12181267	12	-	27260156	PANC1	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.13703550970759615	[952]	[980,1124,724,811]	2	hSpCas9	negative selection	8220873
12179926	12179949	12	-	27260156	PANC1	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.1636013282547849	[348]	[360,388,173,178]	-3	hSpCas9	negative selection	8285130
12184018	12184041	12	-	27260156	PANC1	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.20987281168371796	[1034]	[662,993,766,697]	-3	hSpCas9	negative selection	8285131
12184033	12184056	12	+	27260156	PANC1	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.04756033821517658	[277]	[232,264,191,235]	-1	hSpCas9	negative selection	8285132
12181305	12181328	12	-	27260156	PANC0813	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.3585978602172102	[1177]	[2101,1843,1860,1341]	6	hSpCas9	negative selection	8342122
12179902	12179925	12	-	27260156	PANC0813	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.10888388748961741	[1188]	[1241,1981,1331,1443]	1	hSpCas9	negative selection	8342123
12181244	12181267	12	-	27260156	PANC0813	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.17334305453148002	[952]	[1553,921,1184,1404]	3	hSpCas9	negative selection	8342124
12179926	12179949	12	-	27260156	PANC0813	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.28414097999032084	[348]	[401,373,330,249]	-4	hSpCas9	negative selection	8406381
12184018	12184041	12	-	27260156	PANC0813	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.409008740558109	[1034]	[1053,883,744,985]	-6	hSpCas9	negative selection	8406382
12184033	12184056	12	+	27260156	PANC0813	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.10271715195571807	[277]	[419,319,266,223]	-2	hSpCas9	negative selection	8406383
12181305	12181328	12	-	27260156	RDES	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	-0.09641679436407169	[1177]	[1096,1169,1313,1536]	-2	hSpCas9	negative selection	8463373
12179902	12179925	12	-	27260156	RDES	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	-0.189231084390157	[1188]	[881,1264,1341,1365]	-3	hSpCas9	negative selection	8463374
12181244	12181267	12	-	27260156	RDES	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.05399602707886708	[952]	[916,1133,1271,1265]	0	hSpCas9	negative selection	8463375
12179926	12179949	12	-	27260156	RDES	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.24061596899672888	[348]	[294,302,343,433]	-4	hSpCas9	negative selection	8527632
12184018	12184041	12	-	27260156	RDES	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.20251145060847187	[1034]	[854,920,1218,1191]	-3	hSpCas9	negative selection	8527633
12184033	12184056	12	+	27260156	RDES	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.11421855698918959	[277]	[241,267,333,352]	-2	hSpCas9	negative selection	8527634
12181305	12181328	12	-	27260156	PC3	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.07241116630681543	[1177]	[801,1396,2182,968]	1	hSpCas9	negative selection	8584624
12179902	12179925	12	-	27260156	PC3	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.20592732301168337	[1188]	[934,1337,2100,1428]	4	hSpCas9	negative selection	8584625
12181244	12181267	12	-	27260156	PC3	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.0979959032812634	[952]	[603,1058,1399,1245]	2	hSpCas9	negative selection	8584626
12179926	12179949	12	-	27260156	PC3	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.6421942325223676	[348]	[166,217,257,262]	-9	hSpCas9	negative selection	8648883
12184018	12184041	12	-	27260156	PC3	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	0.13851518098739501	[1034]	[561,1230,1783,1383]	3	hSpCas9	negative selection	8648884
12184033	12184056	12	+	27260156	PC3	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.5876308781751012	[277]	[76,242,322,178]	-8	hSpCas9	negative selection	8648885
12181305	12181328	12	-	27260156	PATU8988T	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	-0.35719207817747534	[1177]	[838,959,485,1315]	-5	hSpCas9	negative selection	8705875
12179902	12179925	12	-	27260156	PATU8988T	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.22849795085895241	[1188]	[1300,1366,1300,1423]	4	hSpCas9	negative selection	8705876
12181244	12181267	12	-	27260156	PATU8988T	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.044487377306588805	[952]	[1095,886,783,1034]	0	hSpCas9	negative selection	8705877
12179926	12179949	12	-	27260156	PATU8988T	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.716951287876752	[348]	[268,239,161,148]	-8	hSpCas9	negative selection	8770134
12184018	12184041	12	-	27260156	PATU8988T	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.1076846367515536	[1034]	[853,1120,867,884]	-2	hSpCas9	negative selection	8770135
12184033	12184056	12	+	27260156	PATU8988T	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	0.10736071768261579	[277]	[212,217,348,376]	1	hSpCas9	negative selection	8770136
12181305	12181328	12	-	27260156	T47D	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.11909477099282162	[1177]	[1487,1499,1452,1520]	2	hSpCas9	negative selection	8827126
12179902	12179925	12	-	27260156	T47D	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.2110413484369038	[1188]	[1507,1409,1570,1951]	4	hSpCas9	negative selection	8827127
12181244	12181267	12	-	27260156	T47D	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.24366143266530904	[952]	[1375,1284,1241,1359]	5	hSpCas9	negative selection	8827128
12179926	12179949	12	-	27260156	T47D	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.4191523225234529	[348]	[357,304,232,321]	-7	hSpCas9	negative selection	8891385
12184018	12184041	12	-	27260156	T47D	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.018087781549159798	[1034]	[1199,1042,1158,1379]	0	hSpCas9	negative selection	8891386
12184033	12184056	12	+	27260156	T47D	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	0.07472126351634634	[277]	[337,358,281,385]	1	hSpCas9	negative selection	8891387
12181305	12181328	12	-	27260156	SU8686	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	0.19017942442021152	[1177]	[1108,1318,1509,1429]	3	hSpCas9	negative selection	8948377
12179902	12179925	12	-	27260156	SU8686	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.23983348302268426	[1188]	[1302,1235,1494,1588]	4	hSpCas9	negative selection	8948378
12181244	12181267	12	-	27260156	SU8686	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.2478474873898182	[952]	[860,1054,1341,1293]	4	hSpCas9	negative selection	8948379
12179926	12179949	12	-	27260156	SU8686	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.517064918027082	[348]	[169,208,267,348]	-7	hSpCas9	negative selection	9012636
12184018	12184041	12	-	27260156	SU8686	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	0.015208294928532373	[1034]	[872,986,1213,1107]	0	hSpCas9	negative selection	9012637
12184033	12184056	12	+	27260156	SU8686	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.020892159423026913	[277]	[294,296,268,206]	0	hSpCas9	negative selection	9012638
12181305	12181328	12	-	27260156	SKES1	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	-0.05851220946968838	[1177]	[1292,1137,1210,908]	-1	hSpCas9	negative selection	9069628
12179902	12179925	12	-	27260156	SKES1	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.042831280075639855	[1188]	[1186,1410,1197,1109]	0	hSpCas9	negative selection	9069629
12181244	12181267	12	-	27260156	SKES1	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.09121695556817544	[952]	[1019,1172,883,987]	2	hSpCas9	negative selection	9069630
12179926	12179949	12	-	27260156	SKES1	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.9659818132532413	[348]	[130,153,229,184]	-9	hSpCas9	negative selection	9133887
12184018	12184041	12	-	27260156	SKES1	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.12150067640527151	[1034]	[1139,931,919,832]	-3	hSpCas9	negative selection	9133888
12184033	12184056	12	+	27260156	SKES1	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.3981740213330571	[277]	[174,218,237,203]	-7	hSpCas9	negative selection	9133889
12181305	12181328	12	-	27260156	TOV112D	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	-0.08850570132610192	[1177]	[1108,1217,1016,1118]	-2	hSpCas9	negative selection	9190879
12179902	12179925	12	-	27260156	TOV112D	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	0.12295076739397781	[1188]	[1493,1563,1153,1061]	2	hSpCas9	negative selection	9190880
12181244	12181267	12	-	27260156	TOV112D	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.2752455875517774	[952]	[1542,1218,1151,763]	5	hSpCas9	negative selection	9190881
12179926	12179949	12	-	27260156	TOV112D	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.9631094122259544	[348]	[127,186,166,230]	-9	hSpCas9	negative selection	9255138
12184018	12184041	12	-	27260156	TOV112D	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.09777549661340368	[1034]	[934,1218,994,787]	-2	hSpCas9	negative selection	9255139
12184033	12184056	12	+	27260156	TOV112D	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.05163660994583119	[277]	[300,162,214,368]	-1	hSpCas9	negative selection	9255140
12181305	12181328	12	-	27260156	TC71	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	-0.16518098024859817	[1177]	[916,1136,1199,1260]	-4	hSpCas9	negative selection	9312130
12179902	12179925	12	-	27260156	TC71	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	-0.08625759232126251	[1188]	[1161,1100,1181,1368]	-2	hSpCas9	negative selection	9312131
12181244	12181267	12	-	27260156	TC71	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.09289993468505142	[952]	[1070,953,1103,1237]	2	hSpCas9	negative selection	9312132
12179926	12179949	12	-	27260156	TC71	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.46972946521913517	[348]	[250,236,343,244]	-8	hSpCas9	negative selection	9376389
12184018	12184041	12	-	27260156	TC71	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.20796161779489697	[1034]	[831,848,1067,1100]	-5	hSpCas9	negative selection	9376390
12184033	12184056	12	+	27260156	TC71	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	-0.5115407079800609	[277]	[220,162,189,265]	-8	hSpCas9	negative selection	9376391
12181305	12181328	12	-	27260156	TC32	viability	TGCCATAGATTACGATCCTGTGG	LRP6	ENSG00000070018	-0.07984429586461794	[1177]	[961,740,1419,1205]	-1	hSpCas9	negative selection	9433381
12179902	12179925	12	-	27260156	TC32	viability	TGGTTCTGACCGTGTAGTATTGG	LRP6	ENSG00000070018	-0.00483041846411747	[1188]	[973,1003,1330,1175]	0	hSpCas9	negative selection	9433382
12181244	12181267	12	-	27260156	TC32	viability	ATACGCCGTTCATTTATAGATGG	LRP6	ENSG00000070018	0.18047563608986894	[952]	[858,842,1199,1224]	3	hSpCas9	negative selection	9433383
12179926	12179949	12	-	27260156	TC32	viability	GAAAATTGAGCGAGCAGCTCTGG	LRP6	ENSG00000070018	-0.17343681332231742	[348]	[273,310,272,275]	-3	hSpCas9	negative selection	9497640
12184018	12184041	12	-	27260156	TC32	viability	TATCAGTGTGCTTGCCCCACTGG	LRP6	ENSG00000070018	-0.25345599397740615	[1034]	[727,476,1204,1027]	-4	hSpCas9	negative selection	9497641
12184033	12184056	12	+	27260156	TC32	viability	CACTGATAAAAAGGCTTGACTGG	LRP6	ENSG00000070018	0.010602523602605052	[277]	[183,339,238,246]	0	hSpCas9	negative selection	9497642
12150919	12150942	12	+	27869803	HPAFII	viability after 27 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-1.0535215120316646	[130]	[54,14,NaN]	-6	hSpCas9	negative selection	9545722
12158849	12158872	12	+	27869803	HPAFII	viability after 27 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	-0.7274862848098012	[206]	[86,47,NaN]	-5	hSpCas9	negative selection	9545728
12162193	12162216	12	-	27869803	HPAFII	viability after 27 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-1.336972235487	[120]	[22,26,NaN]	-7	hSpCas9	negative selection	9545729
12164476	12164499	12	+	27869803	HPAFII	viability after 27 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.7760473707217106	[309]	[253,299,NaN]	6	hSpCas9	negative selection	9545730
12181030	12181053	12	+	27869803	HPAFII	viability after 27 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	-0.5114175720071714	[332]	[172,80,NaN]	-4	hSpCas9	negative selection	9545750
12186933	12186956	12	-	27869803	HPAFII	viability after 27 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.5274377295721174	[291]	[151,278,NaN]	4	hSpCas9	negative selection	9545756
12150919	12150942	12	+	27869803	HPAFII	viability after 15 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-0.7290863005782131	[130]	[116,64,NaN]	-6	hSpCas9	negative selection	9628171
12158849	12158872	12	+	27869803	HPAFII	viability after 15 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	-0.6121830307729419	[206]	[221,97,NaN]	-6	hSpCas9	negative selection	9628177
12162193	12162216	12	-	27869803	HPAFII	viability after 15 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-0.1867090826650888	[120]	[178,73,NaN]	-2	hSpCas9	negative selection	9628178
12164476	12164499	12	+	27869803	HPAFII	viability after 15 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.31932354882941577	[309]	[485,371,NaN]	3	hSpCas9	negative selection	9628179
12181030	12181053	12	+	27869803	HPAFII	viability after 15 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	0.43759982847230133	[332]	[673,366,NaN]	5	hSpCas9	negative selection	9628199
12186933	12186956	12	-	27869803	HPAFII	viability after 15 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.5021891558674838	[291]	[277,547,NaN]	6	hSpCas9	negative selection	9628205
12150919	12150942	12	+	27869803	ASPC1	viability after 36 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-2.302091977772162	[284]	[0,60,0]	-9	hSpCas9	negative selection	9710620
12158849	12158872	12	+	27869803	ASPC1	viability after 36 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	2.1388265818044405	[361]	[1310,333,197]	9	hSpCas9	negative selection	9710626
12162193	12162216	12	-	27869803	ASPC1	viability after 36 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-0.7384573069538816	[327]	[1,76,107]	-6	hSpCas9	negative selection	9710627
12164476	12164499	12	+	27869803	ASPC1	viability after 36 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	-0.2892720822399155	[835]	[71,407,218]	-3	hSpCas9	negative selection	9710628
12181030	12181053	12	+	27869803	ASPC1	viability after 36 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	0.17066487570896172	[936]	[661,487,62]	1	hSpCas9	negative selection	9710648
12186933	12186956	12	-	27869803	ASPC1	viability after 36 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	-0.2628713947883894	[689]	[223,248,143]	-3	hSpCas9	negative selection	9710654
12150919	12150942	12	+	27869803	PATU8988S	viability after 35 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-0.9825134751948514	[163]	[1,64,NaN]	-7	hSpCas9	negative selection	9793069
12158849	12158872	12	+	27869803	PATU8988S	viability after 35 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	0.22620262111722167	[356]	[31,304,NaN]	2	hSpCas9	negative selection	9793075
12162193	12162216	12	-	27869803	PATU8988S	viability after 35 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-1.3286058054181504	[327]	[94,9,NaN]	-8	hSpCas9	negative selection	9793076
12164476	12164499	12	+	27869803	PATU8988S	viability after 35 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	-0.6126561349610331	[635]	[175,158,NaN]	-6	hSpCas9	negative selection	9793077
12181030	12181053	12	+	27869803	PATU8988S	viability after 35 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	-1.2833308380280597	[778]	[84,172,NaN]	-8	hSpCas9	negative selection	9793097
12186933	12186956	12	-	27869803	PATU8988S	viability after 35 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	-2.2817564492900115	[663]	[52,56,NaN]	-9	hSpCas9	negative selection	9793103
12150919	12150942	12	+	27869803	PATU8988S	viability after 31 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-1.3351818756237601	[163]	[17,35,NaN]	-8	hSpCas9	negative selection	9875518
12158849	12158872	12	+	27869803	PATU8988S	viability after 31 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	-0.08873831756735173	[356]	[33,260,NaN]	-1	hSpCas9	negative selection	9875524
12162193	12162216	12	-	27869803	PATU8988S	viability after 31 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-0.8444904712342655	[327]	[56,92,NaN]	-7	hSpCas9	negative selection	9875525
12164476	12164499	12	+	27869803	PATU8988S	viability after 31 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	-0.43960877765002543	[635]	[131,256,NaN]	-5	hSpCas9	negative selection	9875526
12181030	12181053	12	+	27869803	PATU8988S	viability after 31 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	-0.5036875999807379	[778]	[226,208,NaN]	-5	hSpCas9	negative selection	9875546
12186933	12186956	12	-	27869803	PATU8988S	viability after 31 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	-1.0174235413262567	[663]	[99,169,NaN]	-7	hSpCas9	negative selection	9875552
12150919	12150942	12	+	27869803	HPAFII	viability after 35 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-2.066741495939013	[130]	[28,0,NaN]	-8	hSpCas9	negative selection	9957967
12158849	12158872	12	+	27869803	HPAFII	viability after 35 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	-1.0776134251968204	[206]	[59,37,NaN]	-6	hSpCas9	negative selection	9957973
12162193	12162216	12	-	27869803	HPAFII	viability after 35 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-0.1691659410130717	[120]	[69,36,NaN]	-1	hSpCas9	negative selection	9957974
12164476	12164499	12	+	27869803	HPAFII	viability after 35 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.43197358722271156	[309]	[119,314,NaN]	2	hSpCas9	negative selection	9957975
12181030	12181053	12	+	27869803	HPAFII	viability after 35 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	-0.4083357499989269	[332]	[174,72,NaN]	-3	hSpCas9	negative selection	9957995
12186933	12186956	12	-	27869803	HPAFII	viability after 35 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.14790235600703777	[291]	[80,256,NaN]	0	hSpCas9	negative selection	9958001
12150919	12150942	12	+	27869803	HPAFII	viability after 31 days	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-2.285623955460003	[130]	[27,0,NaN]	-8	hSpCas9	negative selection	10040416
12158849	12158872	12	+	27869803	HPAFII	viability after 31 days	GCATTAAGAGAGTAGTGGGCAGG	LRP6	ENSG00000070018	-1.2241126760453516	[206]	[65,31,NaN]	-6	hSpCas9	negative selection	10040422
12162193	12162216	12	-	27869803	HPAFII	viability after 31 days	CTCGCGTTGGACCCTGCCGAAGG	LRP6	ENSG00000070018	-0.5758866722920426	[120]	[57,31,NaN]	-4	hSpCas9	negative selection	10040423
12164476	12164499	12	+	27869803	HPAFII	viability after 31 days	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	-0.1027759865385405	[309]	[72,258,NaN]	0	hSpCas9	negative selection	10040424
12181030	12181053	12	+	27869803	HPAFII	viability after 31 days	TAGAGCTTCTTACCCAACCATGG	LRP6	ENSG00000070018	-0.5207093801731735	[332]	[191,62,NaN]	-3	hSpCas9	negative selection	10040444
12186933	12186956	12	-	27869803	HPAFII	viability after 31 days	TACATGCCTTCAGCCAACAGAGG	LRP6	ENSG00000070018	0.4804536094435916	[291]	[119,346,NaN]	3	hSpCas9	negative selection	10040450
12158892	12158915	12	+	28162770	P31FUJ	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	0.1677357251693503	[49]	[65]	1	hSpCas9	negative selection	10185863
12266706	12266729	12	+	28162770	P31FUJ	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	-0.09024817448820577	[336]	[371]	-1	hSpCas9	negative selection	10185864
12181052	12181075	12	+	28162770	P31FUJ	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	-0.8445316146983202	[135]	[88]	-6	hSpCas9	negative selection	10185865
12181031	12181054	12	+	28162770	P31FUJ	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	0.3005275278914552	[511]	[740]	3	hSpCas9	negative selection	10185866
12164476	12164499	12	+	28162770	P31FUJ	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.3310986807789479	[321]	[475]	3	hSpCas9	negative selection	10185867
12164431	12164454	12	-	28162770	P31FUJ	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	0.2654486631134466	[159]	[225]	3	hSpCas9	negative selection	10185868
12159938	12159961	12	-	28162770	P31FUJ	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	0.2055677986950888	[551]	[747]	2	hSpCas9	negative selection	10185869
12159032	12159055	12	-	28162770	P31FUJ	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	0.5919873109792462	[187]	[332]	6	hSpCas9	negative selection	10185870
12150919	12150942	12	+	28162770	P31FUJ	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-0.6704884426384226	[106]	[78]	-5	hSpCas9	negative selection	10185871
12124631	12124654	12	+	28162770	P31FUJ	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	-0.5252530982249074	[217]	[177]	-4	hSpCas9	negative selection	10185872
12158892	12158915	12	+	28162770	TF1	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	NaN	[NaN]	[40]	1	hSpCas9	negative selection	10355229
12266706	12266729	12	+	28162770	TF1	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	NaN	[NaN]	[356]	1	hSpCas9	negative selection	10355230
12181052	12181075	12	+	28162770	TF1	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	NaN	[NaN]	[79]	1	hSpCas9	negative selection	10355231
12181031	12181054	12	+	28162770	TF1	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	NaN	[NaN]	[511]	1	hSpCas9	negative selection	10355232
12164476	12164499	12	+	28162770	TF1	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	NaN	[NaN]	[260]	1	hSpCas9	negative selection	10355233
12164431	12164454	12	-	28162770	TF1	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	NaN	[NaN]	[163]	1	hSpCas9	negative selection	10355234
12159938	12159961	12	-	28162770	TF1	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	NaN	[NaN]	[685]	1	hSpCas9	negative selection	10355235
12159032	12159055	12	-	28162770	TF1	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	NaN	[NaN]	[137]	1	hSpCas9	negative selection	10355236
12150919	12150942	12	+	28162770	TF1	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	NaN	[NaN]	[64]	1	hSpCas9	negative selection	10355237
12124631	12124654	12	+	28162770	TF1	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	NaN	[NaN]	[199]	1	hSpCas9	negative selection	10355238
12158892	12158915	12	+	28162770	SKM1	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	0.1779983019779947	[20]	[41]	1	hSpCas9	negative selection	10524595
12266706	12266729	12	+	28162770	SKM1	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	-0.3019946391416193	[52]	[75]	-3	hSpCas9	negative selection	10524596
12181052	12181075	12	+	28162770	SKM1	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	0.4114884321977731	[36]	[86]	4	hSpCas9	negative selection	10524597
12181031	12181054	12	+	28162770	SKM1	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	0.14706644242610345	[164]	[322]	1	hSpCas9	negative selection	10524598
12164476	12164499	12	+	28162770	SKM1	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.4205686052520728	[70]	[167]	4	hSpCas9	negative selection	10524599
12164431	12164454	12	-	28162770	SKM1	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	0.5930358012568383	[59]	[159]	6	hSpCas9	negative selection	10524600
12159938	12159961	12	-	28162770	SKM1	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	1.0447317711145303	[101]	[371]	8	hSpCas9	negative selection	10524601
12159032	12159055	12	-	28162770	SKM1	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	0.6109577092541005	[39]	[107]	6	hSpCas9	negative selection	10524602
12150919	12150942	12	+	28162770	SKM1	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-0.532495080827021	[17]	[21]	-4	hSpCas9	negative selection	10524603
12124631	12124654	12	+	28162770	SKM1	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	0.5613269415295002	[45]	[119]	5	hSpCas9	negative selection	10524604
12158892	12158915	12	+	28162770	SKM1	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	0.1779983019779947	[20]	[41]	1	hSpCas9	negative selection	10693961
12266706	12266729	12	+	28162770	SKM1	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	-0.3019946391416193	[52]	[75]	-3	hSpCas9	negative selection	10693962
12181052	12181075	12	+	28162770	SKM1	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	0.4114884321977731	[36]	[86]	4	hSpCas9	negative selection	10693963
12181031	12181054	12	+	28162770	SKM1	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	0.14706644242610345	[164]	[322]	1	hSpCas9	negative selection	10693964
12164476	12164499	12	+	28162770	SKM1	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.4205686052520728	[70]	[167]	4	hSpCas9	negative selection	10693965
12164431	12164454	12	-	28162770	SKM1	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	0.5930358012568383	[59]	[159]	6	hSpCas9	negative selection	10693966
12159938	12159961	12	-	28162770	SKM1	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	1.0447317711145303	[101]	[371]	8	hSpCas9	negative selection	10693967
12159032	12159055	12	-	28162770	SKM1	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	0.6109577092541005	[39]	[107]	6	hSpCas9	negative selection	10693968
12150919	12150942	12	+	28162770	SKM1	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-0.532495080827021	[17]	[21]	-4	hSpCas9	negative selection	10693969
12124631	12124654	12	+	28162770	SKM1	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	0.5613269415295002	[45]	[119]	5	hSpCas9	negative selection	10693970
12158892	12158915	12	+	28162770	PL21	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	-0.5125784334302088	[58]	[17]	-4	hSpCas9	negative selection	10863327
12266706	12266729	12	+	28162770	PL21	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	-0.9654464512286548	[165]	[36]	-6	hSpCas9	negative selection	10863328
12181052	12181075	12	+	28162770	PL21	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	-1.088429883451611	[170]	[34]	-6	hSpCas9	negative selection	10863329
12181031	12181054	12	+	28162770	PL21	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	-0.46621121307249114	[710]	[223]	-3	hSpCas9	negative selection	10863330
12164476	12164499	12	+	28162770	PL21	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	-1.5643067160989932	[264]	[38]	-7	hSpCas9	negative selection	10863331
12164431	12164454	12	-	28162770	PL21	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	-0.9956474502649584	[196]	[42]	-6	hSpCas9	negative selection	10863332
12159938	12159961	12	-	28162770	PL21	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	0.36884663777496085	[394]	[221]	3	hSpCas9	negative selection	10863333
12159032	12159055	12	-	28162770	PL21	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	-0.2946250772602577	[154]	[54]	-2	hSpCas9	negative selection	10863334
12150919	12150942	12	+	28162770	PL21	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	0.4516783814852843	[41]	[24]	4	hSpCas9	negative selection	10863335
12124631	12124654	12	+	28162770	PL21	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	-0.49464616418458734	[190]	[58]	-4	hSpCas9	negative selection	10863336
12158892	12158915	12	+	28162770	P31FUJ	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	0.1677357251693503	[49]	[65]	1	hSpCas9	negative selection	11032693
12266706	12266729	12	+	28162770	P31FUJ	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	-0.09024817448820577	[336]	[371]	-1	hSpCas9	negative selection	11032694
12181052	12181075	12	+	28162770	P31FUJ	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	-0.8445316146983202	[135]	[88]	-6	hSpCas9	negative selection	11032695
12181031	12181054	12	+	28162770	P31FUJ	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	0.3005275278914552	[511]	[740]	3	hSpCas9	negative selection	11032696
12164476	12164499	12	+	28162770	P31FUJ	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.3310986807789479	[321]	[475]	3	hSpCas9	negative selection	11032697
12164431	12164454	12	-	28162770	P31FUJ	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	0.2654486631134466	[159]	[225]	3	hSpCas9	negative selection	11032698
12159938	12159961	12	-	28162770	P31FUJ	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	0.2055677986950888	[551]	[747]	2	hSpCas9	negative selection	11032699
12159032	12159055	12	-	28162770	P31FUJ	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	0.5919873109792462	[187]	[332]	6	hSpCas9	negative selection	11032700
12150919	12150942	12	+	28162770	P31FUJ	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-0.6704884426384226	[106]	[78]	-5	hSpCas9	negative selection	11032701
12124631	12124654	12	+	28162770	P31FUJ	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	-0.5252530982249074	[217]	[177]	-4	hSpCas9	negative selection	11032702
12158892	12158915	12	+	28162770	OCIAML5	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	-0.05851744833142325	[29]	[51]	0	hSpCas9	negative selection	11202059
12266706	12266729	12	+	28162770	OCIAML5	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	-1.004069664309047	[119]	[107]	-6	hSpCas9	negative selection	11202060
12181052	12181075	12	+	28162770	OCIAML5	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	0.8906582925908941	[74]	[250]	7	hSpCas9	negative selection	11202061
12181031	12181054	12	+	28162770	OCIAML5	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	0.16116058830798852	[379]	[766]	1	hSpCas9	negative selection	11202062
12164476	12164499	12	+	28162770	OCIAML5	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	1.068498961641598	[97]	[370]	8	hSpCas9	negative selection	11202063
12164431	12164454	12	-	28162770	OCIAML5	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	-0.16018886622632883	[116]	[188]	-1	hSpCas9	negative selection	11202064
12159938	12159961	12	-	28162770	OCIAML5	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	0.47832310277156154	[271]	[683]	4	hSpCas9	negative selection	11202065
12159032	12159055	12	-	28162770	OCIAML5	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	1.6903354676291136	[85]	[500]	9	hSpCas9	negative selection	11202066
12150919	12150942	12	+	28162770	OCIAML5	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-0.7976187868416207	[25]	[26]	-5	hSpCas9	negative selection	11202067
12124631	12124654	12	+	28162770	OCIAML5	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	-0.41766374671822204	[73]	[99]	-3	hSpCas9	negative selection	11202068
12158892	12158915	12	+	28162770	EOL1	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	2.6155519097020155	[117]	[380]	9	hSpCas9	negative selection	11371425
12266706	12266729	12	+	28162770	EOL1	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	0.6234937587334352	[222]	[180]	5	hSpCas9	negative selection	11371426
12181052	12181075	12	+	28162770	EOL1	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	0.5964935738863306	[235]	[187]	5	hSpCas9	negative selection	11371427
12181031	12181054	12	+	28162770	EOL1	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	0.251928422492943	[1161]	[728]	2	hSpCas9	negative selection	11371428
12164476	12164499	12	+	28162770	EOL1	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.2344030341573219	[575]	[356]	2	hSpCas9	negative selection	11371429
12164431	12164454	12	-	28162770	EOL1	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	0.726497310606048	[381]	[332]	6	hSpCas9	negative selection	11371430
12159938	12159961	12	-	28162770	EOL1	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	0.6807983526801327	[430]	[363]	6	hSpCas9	negative selection	11371431
12159032	12159055	12	-	28162770	EOL1	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	0.2258163958918039	[210]	[129]	2	hSpCas9	negative selection	11371432
12150919	12150942	12	+	28162770	EOL1	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	0.4708298041276311	[62]	[45]	4	hSpCas9	negative selection	11371433
12124631	12124654	12	+	28162770	EOL1	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	-0.8409869747924428	[186]	[54]	-5	hSpCas9	negative selection	11371434
12158892	12158915	12	+	28162770	MOLM13	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	0.81271787854202	[99]	[126]	6	hSpCas9	negative selection	11540791
12266706	12266729	12	+	28162770	MOLM13	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	-0.5530196082184019	[277]	[136]	-3	hSpCas9	negative selection	11540792
12181052	12181075	12	+	28162770	MOLM13	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	0.5274781778343787	[165]	[172]	4	hSpCas9	negative selection	11540793
12181031	12181054	12	+	28162770	MOLM13	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	0.7998188685894403	[919]	[1157]	6	hSpCas9	negative selection	11540794
12164476	12164499	12	+	28162770	MOLM13	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.6649262286041324	[409]	[469]	5	hSpCas9	negative selection	11540795
12164431	12164454	12	-	28162770	MOLM13	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	0.5810999919925699	[244]	[264]	4	hSpCas9	negative selection	11540796
12159938	12159961	12	-	28162770	MOLM13	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	-0.0063260536690386004	[563]	[405]	0	hSpCas9	negative selection	11540797
12159032	12159055	12	-	28162770	MOLM13	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	0.6535517863408602	[232]	[264]	5	hSpCas9	negative selection	11540798
12150919	12150942	12	+	28162770	MOLM13	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	0.9609293928246957	[80]	[113]	7	hSpCas9	negative selection	11540799
12124631	12124654	12	+	28162770	MOLM13	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	-0.009157780009689698	[205]	[147]	0	hSpCas9	negative selection	11540800
12158892	12158915	12	+	28162770	HEL	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	1.0706003716367842	[83]	[112]	8	hSpCas9	negative selection	11710157
12266706	12266729	12	+	28162770	HEL	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	0.10094419043557429	[213]	[146]	0	hSpCas9	negative selection	11710158
12181052	12181075	12	+	28162770	HEL	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	0.7411425360613514	[169]	[181]	6	hSpCas9	negative selection	11710159
12181031	12181054	12	+	28162770	HEL	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	0.19935670702755148	[770]	[566]	1	hSpCas9	negative selection	11710160
12164476	12164499	12	+	28162770	HEL	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.12700733310204015	[355]	[248]	1	hSpCas9	negative selection	11710161
12164431	12164454	12	-	28162770	HEL	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	0.9251385627010817	[221]	[269]	7	hSpCas9	negative selection	11710162
12159938	12159961	12	-	28162770	HEL	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	-0.1053595045004726	[476]	[283]	-1	hSpCas9	negative selection	11710163
12159032	12159055	12	-	28162770	HEL	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	-0.13149401988253862	[182]	[106]	-1	hSpCas9	negative selection	11710164
12150919	12150942	12	+	28162770	HEL	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-0.4905276988631071	[67]	[30]	-3	hSpCas9	negative selection	11710165
12124631	12124654	12	+	28162770	HEL	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	-2.1054540175891034	[214]	[31]	-8	hSpCas9	negative selection	11710166
12158892	12158915	12	+	28162770	MV411	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	0.19681147771280716	[57]	[55]	1	hSpCas9	negative selection	11879523
12266706	12266729	12	+	28162770	MV411	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	-0.6166790211354517	[161]	[88]	-4	hSpCas9	negative selection	11879524
12181052	12181075	12	+	28162770	MV411	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	0.14139591337245072	[126]	[117]	1	hSpCas9	negative selection	11879525
12181031	12181054	12	+	28162770	MV411	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	0.06501153676397209	[622]	[548]	0	hSpCas9	negative selection	11879526
12164476	12164499	12	+	28162770	MV411	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.5693656456701378	[299]	[374]	5	hSpCas9	negative selection	11879527
12164431	12164454	12	-	28162770	MV411	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	1.476378757948161	[156]	[367]	9	hSpCas9	negative selection	11879528
12159938	12159961	12	-	28162770	MV411	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	0.40513002989074665	[328]	[366]	3	hSpCas9	negative selection	11879529
12159032	12159055	12	-	28162770	MV411	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	1.0233972765648451	[145]	[249]	8	hSpCas9	negative selection	11879530
12150919	12150942	12	+	28162770	MV411	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	1.1084611376339648	[48]	[88]	8	hSpCas9	negative selection	11879531
12124631	12124654	12	+	28162770	MV411	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	-0.37990355220893246	[189]	[122]	-3	hSpCas9	negative selection	11879532
12158892	12158915	12	+	28162770	MONOMAC1	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	-0.5817006972948788	[46]	[35]	-5	hSpCas9	negative selection	12048889
12266706	12266729	12	+	28162770	MONOMAC1	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	-0.8394848424414703	[127]	[81]	-6	hSpCas9	negative selection	12048890
12181052	12181075	12	+	28162770	MONOMAC1	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	-1.0013123761851856	[116]	[66]	-7	hSpCas9	negative selection	12048891
12181031	12181054	12	+	28162770	MONOMAC1	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	0.32240401237574146	[502]	[720]	3	hSpCas9	negative selection	12048892
12164476	12164499	12	+	28162770	MONOMAC1	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.719973788269415	[160]	[303]	7	hSpCas9	negative selection	12048893
12164431	12164454	12	-	28162770	MONOMAC1	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	1.021887555681691	[118]	[276]	8	hSpCas9	negative selection	12048894
12159938	12159961	12	-	28162770	MONOMAC1	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	0.40850653108405455	[231]	[352]	4	hSpCas9	negative selection	12048895
12159032	12159055	12	-	28162770	MONOMAC1	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	-1.7136123728004597	[102]	[35]	-8	hSpCas9	negative selection	12048896
12150919	12150942	12	+	28162770	MONOMAC1	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	-0.16308951513621617	[41]	[42]	-1	hSpCas9	negative selection	12048897
12124631	12124654	12	+	28162770	MONOMAC1	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	0.3175363257702045	[90]	[129]	3	hSpCas9	negative selection	12048898
12158892	12158915	12	+	28162770	OCIAML2	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	1.0439433475875968	[6]	[79]	8	hSpCas9	negative selection	12218255
12266706	12266729	12	+	28162770	OCIAML2	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	-1.4200037521721933	[27]	[57]	-7	hSpCas9	negative selection	12218256
12181052	12181075	12	+	28162770	OCIAML2	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	0.07226861591245093	[28]	[168]	0	hSpCas9	negative selection	12218257
12181031	12181054	12	+	28162770	OCIAML2	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	0.30771664974529633	[121]	[836]	3	hSpCas9	negative selection	12218258
12164476	12164499	12	+	28162770	OCIAML2	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	-0.03569276852561265	[53]	[291]	0	hSpCas9	negative selection	12218259
12164431	12164454	12	-	28162770	OCIAML2	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	0.7532339833109548	[34]	[326]	7	hSpCas9	negative selection	12218260
12159938	12159961	12	-	28162770	OCIAML2	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	0.8808425452592163	[57]	[591]	8	hSpCas9	negative selection	12218261
12159032	12159055	12	-	28162770	OCIAML2	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	-0.07831240246340085	[31]	[167]	0	hSpCas9	negative selection	12218262
12150919	12150942	12	+	28162770	OCIAML2	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	0.1616383902573515	[9]	[61]	1	hSpCas9	negative selection	12218263
12124631	12124654	12	+	28162770	OCIAML2	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	-0.3682681076124834	[16]	[72]	-3	hSpCas9	negative selection	12218264
12158892	12158915	12	+	28162770	OCIAML3	viability	CAACTGGCACAGCCAAGCAGAGG	LRP6	ENSG00000070018	0.10643207781692898	[19]	[64]	1	hSpCas9	negative selection	12387621
12266706	12266729	12	+	28162770	OCIAML3	viability	GGCCAGGAGGCTCCTCAGGACGG	LRP6	ENSG00000070018	-0.0746334812305838	[44]	[128]	0	hSpCas9	negative selection	12387622
12181052	12181075	12	+	28162770	OCIAML3	viability	GGATCTAACACAATAGCCCGGGG	LRP6	ENSG00000070018	-0.936113617149156	[44]	[70]	-6	hSpCas9	negative selection	12387623
12181031	12181054	12	+	28162770	OCIAML3	viability	AGAGCTTCTTACCCAACCATGGG	LRP6	ENSG00000070018	-0.19426001206991472	[165]	[437]	-1	hSpCas9	negative selection	12387624
12164476	12164499	12	+	28162770	OCIAML3	viability	CAATAGGGCAAGCACAGCGAAGG	LRP6	ENSG00000070018	0.033080336069669536	[89]	[277]	0	hSpCas9	negative selection	12387625
12164431	12164454	12	-	28162770	OCIAML3	viability	GAAGACCTGCATTGTCCCAGAGG	LRP6	ENSG00000070018	0.5182018632618619	[33]	[146]	5	hSpCas9	negative selection	12387626
12159938	12159961	12	-	28162770	OCIAML3	viability	ATGTATTGGACTGAATGGGGTGG	LRP6	ENSG00000070018	0.47266339932112444	[110]	[464]	4	hSpCas9	negative selection	12387627
12159032	12159055	12	-	28162770	OCIAML3	viability	GAGCGTGCCAACAAAACCAGTGG	LRP6	ENSG00000070018	-0.04651984502166967	[38]	[113]	0	hSpCas9	negative selection	12387628
12150919	12150942	12	+	28162770	OCIAML3	viability	CAATGGCCCGGACATTCCGAAGG	LRP6	ENSG00000070018	0.9623857082002222	[16]	[99]	8	hSpCas9	negative selection	12387629
12124631	12124654	12	+	28162770	OCIAML3	viability	TCTGTGGCTGGGGATGGTGGAGG	LRP6	ENSG00000070018	-1.0862130001254668	[63]	[90]	-7	hSpCas9	negative selection	12387630