Crispr

Gene Info

• Species:Human (Homo sapiens)
• GeneID:7804
• Symbol:LRP8
• Description:LDL receptor related protein 8

DataSource: http://genomecrispr.dkfz.de/#!/results/LRP8

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Start	The end	chr	strand	pubmed	cellline	condition	sequence	symbol	ensg	log2fc	rc_initial	rc_final	effect	cas	screentype	index
53280616	53280639	1	-	26472758	Jiyoye	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	0.18690926127781335	[112]	[96]	1	hSpCas9	negative selection	92429
53262500	53262523	1	-	26472758	Jiyoye	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	-0.7303281422440615	[54]	[24]	-5	hSpCas9	negative selection	92430
53327870	53327893	1	+	26472758	Jiyoye	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	0.5738252509153248	[48]	[54]	4	hSpCas9	negative selection	92431
53327819	53327842	1	-	26472758	Jiyoye	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	-0.3845826855007121	[160]	[92]	-3	hSpCas9	negative selection	92432
53327794	53327817	1	-	26472758	Jiyoye	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.6702097873396672	[69]	[83]	5	hSpCas9	negative selection	92433
53327785	53327808	1	+	26472758	Jiyoye	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	0.22182033949395494	[140]	[123]	1	hSpCas9	negative selection	92434
53271316	53271339	1	-	26472758	Jiyoye	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	-0.14216320948456151	[239]	[163]	-1	hSpCas9	negative selection	92435
53266598	53266621	1	-	26472758	Jiyoye	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	0.3466338395708228	[72]	[69]	2	hSpCas9	negative selection	92436
53264157	53264180	1	+	26472758	Jiyoye	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	-0.15986521121802033	[199]	[134]	-1	hSpCas9	negative selection	92437
53280616	53280639	1	-	26472758	KBM7	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	0.7372858770304912	[135,147]	[58,159]	7	hSpCas9	negative selection	283547
53262500	53262523	1	-	26472758	KBM7	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	0.08269668956771414	[250,272]	[175,91]	0	hSpCas9	negative selection	283548
53327870	53327893	1	+	26472758	KBM7	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	-0.023911165160837244	[251,167]	[121,71]	0	hSpCas9	negative selection	283549
53327819	53327842	1	-	26472758	KBM7	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	0.1634631967554175	[484,295]	[228,176]	1	hSpCas9	negative selection	283550
53327794	53327817	1	-	26472758	KBM7	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.24080042438310728	[502,252]	[157,244]	2	hSpCas9	negative selection	283551
53327785	53327808	1	+	26472758	KBM7	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	0.30078629145300556	[519,355]	[163,326]	3	hSpCas9	negative selection	283552
53271316	53271339	1	-	26472758	KBM7	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	0.20634258226019586	[837,857]	[588,349]	2	hSpCas9	negative selection	283553
53266598	53266621	1	-	26472758	KBM7	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	0.019428157640675514	[256,348]	[121,169]	0	hSpCas9	negative selection	283554
53264157	53264180	1	+	26472758	KBM7	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	-0.06819298902468163	[635,476]	[149,333]	0	hSpCas9	negative selection	283555
53280616	53280639	1	-	26472758	Raji	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	-1.3951168051555838	[135]	[11]	-7	hSpCas9	negative selection	474665
53262500	53262523	1	-	26472758	Raji	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	-0.6345483116859563	[193]	[28]	-5	hSpCas9	negative selection	474666
53327870	53327893	1	+	26472758	Raji	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	-0.6636752574610149	[156]	[22]	-5	hSpCas9	negative selection	474667
53327819	53327842	1	-	26472758	Raji	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	0.9135038017795646	[166]	[72]	8	hSpCas9	negative selection	474668
53327794	53327817	1	-	26472758	Raji	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.785455440486237	[169]	[67]	7	hSpCas9	negative selection	474669
53327785	53327808	1	+	26472758	Raji	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	1.0468419934385487	[145]	[69]	8	hSpCas9	negative selection	474670
53271316	53271339	1	-	26472758	Raji	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	0.11345804978328378	[473]	[118]	1	hSpCas9	negative selection	474671
53266598	53266621	1	-	26472758	Raji	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	1.8482963140564685	[72]	[60]	9	hSpCas9	negative selection	474672
53264157	53264180	1	+	26472758	Raji	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	-0.5079526143910756	[287]	[46]	-4	hSpCas9	negative selection	474673
53280616	53280639	1	-	26472758	K562	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	-0.3823639487493362	[209]	[135]	-3	hSpCas9	negative selection	665783
53262500	53262523	1	-	26472758	K562	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	-1.2553414505178242	[262]	[92]	-6	hSpCas9	negative selection	665784
53327870	53327893	1	+	26472758	K562	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	0.054402308284665524	[234]	[205]	0	hSpCas9	negative selection	665785
53327819	53327842	1	-	26472758	K562	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	0.5565436475234504	[442]	[549]	4	hSpCas9	negative selection	665786
53327794	53327817	1	-	26472758	K562	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.022026306329998968	[314]	[269]	0	hSpCas9	negative selection	665787
53327785	53327808	1	+	26472758	K562	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	0.764286200165718	[271]	[389]	6	hSpCas9	negative selection	665788
53271316	53271339	1	-	26472758	K562	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	-0.6170143182941981	[862]	[474]	-4	hSpCas9	negative selection	665789
53266598	53266621	1	-	26472758	K562	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	1.3406340429257502	[202]	[433]	9	hSpCas9	negative selection	665790
53264157	53264180	1	+	26472758	K562	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	-0.924368950074167	[316]	[140]	-5	hSpCas9	negative selection	665791
53271051	53271074	1	+	26627737	DLD1	viability	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	1.0508604096735956	[141]	[53,92,123]	8	hSpCas9	negative selection	772047
53271328	53271351	1	+	26627737	DLD1	viability	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.24989608390820162	[537]	[206,24,180]	-3	hSpCas9	negative selection	772048
53274723	53274746	1	-	26627737	DLD1	viability	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	-0.023029695729745947	[644]	[269,181,149]	0	hSpCas9	negative selection	772049
53277011	53277034	1	+	26627737	DLD1	viability	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	-0.5949933028675011	[1065]	[266,237,165]	-5	hSpCas9	negative selection	772050
53326915	53326938	1	+	26627737	DLD1	viability	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	0.4632203094148275	[1523]	[759,580,629]	5	hSpCas9	negative selection	772051
53271051	53271074	1	+	26627737	GBM cells	viability after 5 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	0.341857370734414	[127]	[88,84]	5	hSpCas9	negative selection	854362
53271328	53271351	1	+	26627737	GBM cells	viability after 5 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.6252453467732707	[301]	[95,113]	-7	hSpCas9	negative selection	854363
53274723	53274746	1	-	26627737	GBM cells	viability after 5 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	-0.05893267369936883	[370]	[192,188]	-1	hSpCas9	negative selection	854364
53277011	53277034	1	+	26627737	GBM cells	viability after 5 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	0.24922377114287042	[301]	[242,141]	4	hSpCas9	negative selection	854365
53326915	53326938	1	+	26627737	GBM cells	viability after 5 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	0.010752515242273608	[793]	[506,350]	0	hSpCas9	negative selection	854366
53271051	53271074	1	+	26627737	GBM cells	viability after 13 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	0.09499284265632812	[127]	[82,66]	1	hSpCas9	negative selection	936677
53271328	53271351	1	+	26627737	GBM cells	viability after 13 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.6862702706406572	[301]	[108,95]	-7	hSpCas9	negative selection	936678
53274723	53274746	1	-	26627737	GBM cells	viability after 13 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.03564370794707439	[370]	[250,169]	0	hSpCas9	negative selection	936679
53277011	53277034	1	+	26627737	GBM cells	viability after 13 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	0.649116536353819	[301]	[326,199]	7	hSpCas9	negative selection	936680
53326915	53326938	1	+	26627737	GBM cells	viability after 13 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	0.1864817466276385	[793]	[583,413]	2	hSpCas9	negative selection	936681
53271051	53271074	1	+	26627737	GBM cells	viability after 21 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	-0.33520455482133815	[127]	[63,46]	-3	hSpCas9	negative selection	1018992
53271328	53271351	1	+	26627737	GBM cells	viability after 21 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.36406947488203234	[301]	[127,126]	-3	hSpCas9	negative selection	1018993
53274723	53274746	1	-	26627737	GBM cells	viability after 21 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.5271867253015043	[370]	[302,278]	5	hSpCas9	negative selection	1018994
53277011	53277034	1	+	26627737	GBM cells	viability after 21 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	-0.3745444094436212	[301]	[136,116]	-3	hSpCas9	negative selection	1018995
53326915	53326938	1	+	26627737	GBM cells	viability after 21 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	-0.274868743042465	[793]	[343,367]	-3	hSpCas9	negative selection	1018996
53271051	53271074	1	+	26627737	RPE1	viability after 9 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	-2.280141848582358	[773]	[55,41]	-9	hSpCas9	negative selection	1101307
53271328	53271351	1	+	26627737	RPE1	viability after 9 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.38261860654428126	[1184]	[377,163]	-3	hSpCas9	negative selection	1101308
53274723	53274746	1	-	26627737	RPE1	viability after 9 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.19215246456586343	[1309]	[492,436]	1	hSpCas9	negative selection	1101309
53277011	53277034	1	+	26627737	RPE1	viability after 9 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	-0.2659964851523508	[1153]	[120,531]	-2	hSpCas9	negative selection	1101310
53326915	53326938	1	+	26627737	RPE1	viability after 9 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	0.1950119292379373	[3174]	[1160,1107]	1	hSpCas9	negative selection	1101311
53271051	53271074	1	+	26627737	RPE1	viability after 12 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	-0.6840660264826414	[773]	[75,185]	-5	hSpCas9	negative selection	1183622
53271328	53271351	1	+	26627737	RPE1	viability after 12 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.902988416943814	[1184]	[212,124]	-6	hSpCas9	negative selection	1183623
53274723	53274746	1	-	26627737	RPE1	viability after 12 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.2742115037822297	[1309]	[344,510]	1	hSpCas9	negative selection	1183624
53277011	53277034	1	+	26627737	RPE1	viability after 12 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	-0.16078933730412903	[1153]	[186,372]	-1	hSpCas9	negative selection	1183625
53326915	53326938	1	+	26627737	RPE1	viability after 12 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	0.24741920914869597	[3174]	[981,1044]	1	hSpCas9	negative selection	1183626
53271051	53271074	1	+	26627737	RPE1	viability after 15 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	-2.5900815929306553	[773]	[15,55]	-8	hSpCas9	negative selection	1265937
53271328	53271351	1	+	26627737	RPE1	viability after 15 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-1.1499342166214839	[1184]	[231,72]	-6	hSpCas9	negative selection	1265938
53274723	53274746	1	-	26627737	RPE1	viability after 15 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	-0.018116433978598856	[1309]	[368,362]	0	hSpCas9	negative selection	1265939
53277011	53277034	1	+	26627737	RPE1	viability after 15 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	0.3934322208709077	[1153]	[243,606]	2	hSpCas9	negative selection	1265940
53326915	53326938	1	+	26627737	RPE1	viability after 15 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	0.5164303918818791	[3174]	[1469,1105]	3	hSpCas9	negative selection	1265941
53271051	53271074	1	+	26627737	RPE1	viability after 18 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	-1.3272868656243115	[773]	[133,28]	-7	hSpCas9	negative selection	1348252
53271328	53271351	1	+	26627737	RPE1	viability after 18 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.22691914238403416	[1184]	[367,171]	-1	hSpCas9	negative selection	1348253
53274723	53274746	1	-	26627737	RPE1	viability after 18 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.42922111034141297	[1309]	[403,552]	2	hSpCas9	negative selection	1348254
53277011	53277034	1	+	26627737	RPE1	viability after 18 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	0.5367388369068032	[1153]	[226,691]	3	hSpCas9	negative selection	1348255
53326915	53326938	1	+	26627737	RPE1	viability after 18 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	0.4357509380928488	[3174]	[1157,1159]	2	hSpCas9	negative selection	1348256
53271051	53271074	1	+	26627737	HeLa	viability after 8 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	0.0927208136868232	[311]	[180,126,134]	0	hSpCas9	negative selection	1430567
53271328	53271351	1	+	26627737	HeLa	viability after 8 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	1.282758992115495	[239]	[254,290,218]	8	hSpCas9	negative selection	1430568
53274723	53274746	1	-	26627737	HeLa	viability after 8 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.12404177679879841	[519]	[163,257,295]	1	hSpCas9	negative selection	1430569
53277011	53277034	1	+	26627737	HeLa	viability after 8 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	-1.4275219718579661	[584]	[86,37,152]	-9	hSpCas9	negative selection	1430570
53326915	53326938	1	+	26627737	HeLa	viability after 8 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	0.541084537190686	[1480]	[1259,863,771]	5	hSpCas9	negative selection	1430571
53271051	53271074	1	+	26627737	HeLa	viability after 12 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	-1.9410973905287157	[311]	[10,5,85]	-9	hSpCas9	negative selection	1512882
53271328	53271351	1	+	26627737	HeLa	viability after 12 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	1.499627243772638	[239]	[211,387,227]	8	hSpCas9	negative selection	1512883
53274723	53274746	1	-	26627737	HeLa	viability after 12 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	-0.5059073161604248	[519]	[61,258,118]	-4	hSpCas9	negative selection	1512884
53277011	53277034	1	+	26627737	HeLa	viability after 12 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	0.307977776791436	[584]	[175,386,321]	2	hSpCas9	negative selection	1512885
53326915	53326938	1	+	26627737	HeLa	viability after 12 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	-0.26737713012314046	[1480]	[530,377,630]	-2	hSpCas9	negative selection	1512886
53271051	53271074	1	+	26627737	HeLa	viability after 15 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	-0.6894554104826046	[311]	[77,70,87]	-6	hSpCas9	negative selection	1595197
53271328	53271351	1	+	26627737	HeLa	viability after 15 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	0.9146862309388784	[239]	[123,357,61]	7	hSpCas9	negative selection	1595198
53274723	53274746	1	-	26627737	HeLa	viability after 15 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.2880867683659994	[519]	[204,422,138]	2	hSpCas9	negative selection	1595199
53277011	53277034	1	+	26627737	HeLa	viability after 15 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	-0.06501060075115428	[584]	[161,267,255]	0	hSpCas9	negative selection	1595200
53326915	53326938	1	+	26627737	HeLa	viability after 15 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	-0.025606034532379196	[1480]	[588,365,840]	0	hSpCas9	negative selection	1595201
53271051	53271074	1	+	26627737	HeLa	viability after 18 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	-0.6501374255097507	[311]	[53,61,87]	-5	hSpCas9	negative selection	1677512
53271328	53271351	1	+	26627737	HeLa	viability after 18 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	0.9245322515902835	[239]	[85,295,61]	7	hSpCas9	negative selection	1677513
53274723	53274746	1	-	26627737	HeLa	viability after 18 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.24807656687585272	[519]	[131,339,138]	2	hSpCas9	negative selection	1677514
53277011	53277034	1	+	26627737	HeLa	viability after 18 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	-0.049539068529831365	[584]	[110,224,255]	0	hSpCas9	negative selection	1677515
53326915	53326938	1	+	26627737	HeLa	viability after 18 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	-0.02216145068371045	[1480]	[397,302,840]	0	hSpCas9	negative selection	1677516
53271051	53271074	1	+	26627737	HCT116	viability after 6 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	1.058178225899619	[195]	[165,7]	6	hSpCas9	negative selection	1759827
53271328	53271351	1	+	26627737	HCT116	viability after 6 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-1.4442676227056317	[1012]	[131,17]	-7	hSpCas9	negative selection	1759828
53274723	53274746	1	-	26627737	HCT116	viability after 6 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	-1.3976074327625518	[1185]	[131,36]	-7	hSpCas9	negative selection	1759829
53277011	53277034	1	+	26627737	HCT116	viability after 6 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	0.2518810097294063	[900]	[187,157]	1	hSpCas9	negative selection	1759830
53326915	53326938	1	+	26627737	HCT116	viability after 6 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	0.35345695523319565	[1680]	[423,289]	2	hSpCas9	negative selection	1759831
53271051	53271074	1	+	26627737	HCT116	viability after 8 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	1.5486733756595594	[49]	[37,118,83]	9	hSpCas9	negative selection	1842142
53271328	53271351	1	+	26627737	HCT116	viability after 8 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.5224518618827882	[566]	[177,187,284]	-6	hSpCas9	negative selection	1842143
53274723	53274746	1	-	26627737	HCT116	viability after 8 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.6945917113712325	[358]	[223,352,380]	6	hSpCas9	negative selection	1842144
53277011	53277034	1	+	26627737	HCT116	viability after 8 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	-0.2352938390355357	[586]	[274,246,301]	-3	hSpCas9	negative selection	1842145
53326915	53326938	1	+	26627737	HCT116	viability after 8 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	0.07828177701112038	[997]	[612,602,526]	0	hSpCas9	negative selection	1842146
53271051	53271074	1	+	26627737	HCT116	viability after 9 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	1.7826384237595674	[195]	[250,123]	9	hSpCas9	negative selection	1924457
53271328	53271351	1	+	26627737	HCT116	viability after 9 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	0.12602339747972757	[1012]	[240,337]	1	hSpCas9	negative selection	1924458
53274723	53274746	1	-	26627737	HCT116	viability after 9 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	-0.6166173064639737	[1185]	[105,285]	-4	hSpCas9	negative selection	1924459
53277011	53277034	1	+	26627737	HCT116	viability after 9 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	0.9126581144840203	[900]	[615,323]	6	hSpCas9	negative selection	1924460
53326915	53326938	1	+	26627737	HCT116	viability after 9 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	-0.06246552194936239	[1680]	[459,405]	0	hSpCas9	negative selection	1924461
53271051	53271074	1	+	26627737	HCT116	viability after 12 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	2.2359958018496986	[49]	[113,114,142]	9	hSpCas9	negative selection	2006772
53271328	53271351	1	+	26627737	HCT116	viability after 12 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.611059247106567	[566]	[203,133,244]	-6	hSpCas9	negative selection	2006773
53274723	53274746	1	-	26627737	HCT116	viability after 12 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.9317771018116341	[358]	[297,477,311]	7	hSpCas9	negative selection	2006774
53277011	53277034	1	+	26627737	HCT116	viability after 12 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	-0.3657779103454346	[586]	[205,233,280]	-4	hSpCas9	negative selection	2006775
53326915	53326938	1	+	26627737	HCT116	viability after 12 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	0.11859333572655184	[997]	[820,563,300]	1	hSpCas9	negative selection	2006776
53271051	53271074	1	+	26627737	HCT116	viability after 15 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	1.6249642049418873	[49]	[96,103,65]	9	hSpCas9	negative selection	2089087
53271328	53271351	1	+	26627737	HCT116	viability after 15 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.26032270837512217	[566]	[174,206,419]	-3	hSpCas9	negative selection	2089088
53274723	53274746	1	-	26627737	HCT116	viability after 15 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.9562710927245595	[358]	[435,494,274]	7	hSpCas9	negative selection	2089089
53277011	53277034	1	+	26627737	HCT116	viability after 15 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	-0.07025142900481485	[586]	[133,443,361]	0	hSpCas9	negative selection	2089090
53326915	53326938	1	+	26627737	HCT116	viability after 15 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	0.2369708495154088	[997]	[741,576,714]	2	hSpCas9	negative selection	2089091
53271051	53271074	1	+	26627737	HCT116	viability after 18 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	1.8313295251678159	[49]	[100,88,66]	9	hSpCas9	negative selection	2171402
53271328	53271351	1	+	26627737	HCT116	viability after 18 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.1514040804948158	[566]	[56,276,411]	-1	hSpCas9	negative selection	2171403
53274723	53274746	1	-	26627737	HCT116	viability after 18 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.774012182425859	[358]	[180,415,284]	6	hSpCas9	negative selection	2171404
53277011	53277034	1	+	26627737	HCT116	viability after 18 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	0.2823623878622099	[586]	[257,392,382]	2	hSpCas9	negative selection	2171405
53326915	53326938	1	+	26627737	HCT116	viability after 18 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	0.5911007130616079	[997]	[752,736,687]	5	hSpCas9	negative selection	2171406
53327822	53327847	1	-	24717434	HeLa	essential genes for diphteria toxin toxicity	CTGCTGCAGCTCCAGCATCTTGCGG	LRP8	ENSG00000157193	-0.1293242612466179	[4417,5218,4122]	[1,1,0]	-1	hSpCas9	positive selection	2381094
53327797	53327822	1	-	24717434	HeLa	essential genes for diphteria toxin toxicity	CGGCAGCGGCTGATCCGCTGCTCGG	LRP8	ENSG00000157193	2.444692657264326	[3019,1997,2874]	[8,4,2]	5	hSpCas9	positive selection	2381095
53327794	53327819	1	-	24717434	HeLa	essential genes for diphteria toxin toxicity	CAGCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.7285357798973505	[1756,1236,1582]	[0,0,0]	2	hSpCas9	positive selection	2381096
53327822	53327847	1	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	CTGCTGCAGCTCCAGCATCTTGCGG	LRP8	ENSG00000157193	10.495808457246165	[4417,5218,4122]	[7893,2,3]	9	hSpCas9	positive selection	2382361
53327822	53327847	1	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	CTGCTGCAGCTCCAGCATCTTGCGG	LRP8	ENSG00000157193	10.495808457246165	[4417,5218,4122]	[7893,2,3]	9	hSpCas9	positive selection	2382362
53327822	53327847	1	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	CTGCTGCAGCTCCAGCATCTTGCGG	LRP8	ENSG00000157193	10.495808457246165	[4417,5218,4122]	[7893,2,3]	9	hSpCas9	positive selection	2382363
53327797	53327822	1	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	CGGCAGCGGCTGATCCGCTGCTCGG	LRP8	ENSG00000157193	11.622410976794232	[3019,1997,2874]	[167,3495,6176]	9	hSpCas9	positive selection	2382364
53327797	53327822	1	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	CGGCAGCGGCTGATCCGCTGCTCGG	LRP8	ENSG00000157193	11.622410976794232	[3019,1997,2874]	[167,3495,6176]	9	hSpCas9	positive selection	2382365
53327797	53327822	1	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	CGGCAGCGGCTGATCCGCTGCTCGG	LRP8	ENSG00000157193	11.622410976794232	[3019,1997,2874]	[167,3495,6176]	9	hSpCas9	positive selection	2382366
53327794	53327819	1	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	CAGCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.7288693068640758	[1756,1236,1582]	[0,0,0]	2	hSpCas9	positive selection	2382367
53327794	53327819	1	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	CAGCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.7288693068640758	[1756,1236,1582]	[0,0,0]	2	hSpCas9	positive selection	2382368
53327794	53327819	1	-	24717434	HeLa	essential genes for PA/LFnDTA toxicity	CAGCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.7288693068640758	[1756,1236,1582]	[0,0,0]	2	hSpCas9	positive selection	2382369
53312402	53312425	1	+	25494202	A375	resistance to PLX-4720 (puromycin)	TTACCCAGGCCAGAGTGCAGCGG	LRP8	ENSG00000157193	0.6272070108845731	[55,201]	[18,70]	2	dCas9-VP64	positive selection	2448190
53312402	53312425	1	+	25494202	A375	resistance to PLX-4720 (zeocin)	TTACCCAGGCCAGAGTGCAGCGG	LRP8	ENSG00000157193	2.96880741897745	[414,208]	[170,1396]	9	dCas9-VP64	positive selection	2543445
53326916	53326939	1	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	-0.48883820879847983	[2,2]	[1,0]	-6	hSpCas9	positive selection	3000016
53327819	53327842	1	-	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	-0.4399976406666851	[2,2]	[1,0]	-6	hSpCas9	positive selection	3000017
53271053	53271076	1	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	GTAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	-0.4061060926757499	[3,3]	[2,1]	-5	hSpCas9	positive selection	3000018
53266470	53266493	1	+	27453484	HT29	resistance to T3SS1-dependent cytotoxicity	TCACCTATAGATCTTACGGTAGG	LRP8	ENSG00000157193	-0.28341511696264027	[3,3]	[2,1]	-4	hSpCas9	positive selection	3000019
53326916	53326939	1	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	0.4939837536878184	[2,2]	[3,2]	8	hSpCas9	positive selection	3067874
53327819	53327842	1	-	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	-0.2946895209341531	[2,2]	[2,0]	-4	hSpCas9	positive selection	3067875
53271053	53271076	1	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	GTAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	-0.042355261310921266	[3,3]	[2,2]	0	hSpCas9	positive selection	3067876
53266470	53266493	1	+	27453484	HT29	resistance to T3SS2-dependent cytotoxicity	TCACCTATAGATCTTACGGTAGG	LRP8	ENSG00000157193	0.19187548574437496	[3,3]	[2,2]	3	hSpCas9	positive selection	3067877
53326925	53326948		-	24336571	A375	resistance to PLX after 7 days	AGCGCTGCATCCCCTCTGTGTGG	LRP8	ENSG00000157193	-0.03561706449129254	[48,53]	[47,51]	-1	hSpCas9	positive selection	3125220
53326873	53326896		+	24336571	A375	resistance to PLX after 7 days	GGCAGTCGTCCTCGTCGCTGTGG	LRP8	ENSG00000157193	0.11335761802190447	[43,37]	[43,44]	4	hSpCas9	positive selection	3125221
53326925	53326948		-	24336571	A375	resistance to PLX after 14 days	AGCGCTGCATCCCCTCTGTGTGG	LRP8	ENSG00000157193	-0.8261678704812241	[58,44]	[13,12]	-8	hSpCas9	positive selection	3183013
53326873	53326896		+	24336571	A375	resistance to PLX after 14 days	GGCAGTCGTCCTCGTCGCTGTGG	LRP8	ENSG00000157193	-0.1955010112248361	[46,46]	[19,17]	-2	hSpCas9	positive selection	3183014
53326925	53326948		-	24336571	A375	viability after 7 days	AGCGCTGCATCCCCTCTGTGTGG	LRP8	ENSG00000157193	-0.12772813845960163	[58]	[48,53]	-2	hSpCas9	negative selection	3240806
53326873	53326896		+	24336571	A375	viability after 7 days	GGCAGTCGTCCTCGTCGCTGTGG	LRP8	ENSG00000157193	0.05979839784949603	[40]	[43,37]	0	hSpCas9	negative selection	3240807
53326925	53326948		-	24336571	A375	viability after 14 days	AGCGCTGCATCCCCTCTGTGTGG	LRP8	ENSG00000157193	-0.0975685319549644	[58]	[58,44]	-1	hSpCas9	negative selection	3298599
53326873	53326896		+	24336571	A375	viability after 14 days	GGCAGTCGTCCTCGTCGCTGTGG	LRP8	ENSG00000157193	0.2645693938914764	[40]	[46,46]	3	hSpCas9	negative selection	3298600
53280630	53280653	1	+	27383988	293T	resistance to West Nile virus (flavivirus)	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	1.449971289388231	[55,55]	[0,0]	6	hSpCas9	positive selection	3377587
53280645	53280668	1	-	27383988	293T	resistance to West Nile virus (flavivirus)	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	1.6134700216711104	[49,49]	[0,0]	6	hSpCas9	positive selection	3377588
53326915	53326938	1	+	26780180	HT29	viability (Avana library 4 designs)	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	2.22768439361209	[]	[]	7	hSpCas9	negative selection	3437585
53327819	53327842	1	-	26780180	HT29	viability (Avana library 4 designs)	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	1.42065320422529	[]	[]	5	hSpCas9	negative selection	3437586
53271052	53271075	1	+	26780180	HT29	viability (Avana library 4 designs)	GTAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	0.535977826804362	[]	[]	2	hSpCas9	negative selection	3437587
53266469	53266492	1	+	26780180	HT29	viability (Avana library 4 designs)	TCACCTATAGATCTTACGGTAGG	LRP8	ENSG00000157193	0.11817440870382	[]	[]	0	hSpCas9	negative selection	3437588
53271052	53271075	1	+	26780180	A375	viability (Avana lentiCRISPRv2)	GTAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	2.38542708189285	[]	[]	3	hSpCas9	negative selection	3526379
53327819	53327842	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	0.773469956722437	[]	[]	1	hSpCas9	negative selection	3526380
53326915	53326938	1	+	26780180	A375	viability (Avana lentiCRISPRv2)	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	2.82400667890045	[]	[]	4	hSpCas9	negative selection	3526381
53266469	53266492	1	+	26780180	A375	viability (Avana lentiCRISPRv2)	TCACCTATAGATCTTACGGTAGG	LRP8	ENSG00000157193	-8.90830581418891	[]	[]	-7	hSpCas9	negative selection	3526382
53326912	53326935	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	CTCTGTGTGGAGATGCGACGAGG	LRP8	ENSG00000157193	-0.951896220593349	[]	[]	-1	hSpCas9	negative selection	3526383
53326882	53326905	1	-	26780180	A375	viability (Avana lentiCRISPRv2)	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	5.64168887023502	[]	[]	8	hSpCas9	negative selection	3526384
53271052	53271075	1	+	26780180	A375	viability (Avana lentiGuide)	GTAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	1.10938264795815	[]	[]	1	hSpCas9	negative selection	3635038
53327819	53327842	1	-	26780180	A375	viability (Avana lentiGuide)	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	2.78510534394156	[]	[]	3	hSpCas9	negative selection	3635039
53326915	53326938	1	+	26780180	A375	viability (Avana lentiGuide)	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	2.27590414663044	[]	[]	2	hSpCas9	negative selection	3635040
53266469	53266492	1	+	26780180	A375	viability (Avana lentiGuide)	TCACCTATAGATCTTACGGTAGG	LRP8	ENSG00000157193	4.53805482117683	[]	[]	4	hSpCas9	negative selection	3635041
53326912	53326935	1	-	26780180	A375	viability (Avana lentiGuide)	CTCTGTGTGGAGATGCGACGAGG	LRP8	ENSG00000157193	12.1530700209927	[]	[]	7	hSpCas9	negative selection	3635042
53326882	53326905	1	-	26780180	A375	viability (Avana lentiGuide)	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	1.17592674680261	[]	[]	1	hSpCas9	negative selection	3635043
53271052	53271075	1	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GTAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	0.05136255766961343	[5]	[6,4]	1	hSpCas9	positive selection	3743697
53327819	53327842	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	0.2594555773639163	[4]	[5,4]	7	hSpCas9	positive selection	3743698
53326915	53326938	1	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	-0.5716910965821443	[3]	[2,1]	-7	hSpCas9	positive selection	3743699
53266469	53266492	1	+	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	TCACCTATAGATCTTACGGTAGG	LRP8	ENSG00000157193	-0.3380502286976752	[8]	[5,6]	-5	hSpCas9	positive selection	3743700
53326912	53326935	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTCTGTGTGGAGATGCGACGAGG	LRP8	ENSG00000157193	0.1441072288831261	[5]	[6,4]	4	hSpCas9	positive selection	3743701
53326882	53326905	1	-	26780180	A375	resistance to vemurafenib (Avana lentiCRISPRv2)	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	0.2907436202406482	[5]	[6,6]	8	hSpCas9	positive selection	3743702
53271052	53271075	1	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GTAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	0.01907906921127661	[5]	[3,5]	0	hSpCas9	positive selection	3852304
53327819	53327842	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	-1.0330616561007797	[5]	[1,1]	-8	hSpCas9	positive selection	3852305
53326915	53326938	1	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	-0.3692118922893447	[4]	[2,2]	-5	hSpCas9	positive selection	3852306
53266469	53266492	1	+	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	TCACCTATAGATCTTACGGTAGG	LRP8	ENSG00000157193	-0.0695161425573742	[5]	[3,4]	-1	hSpCas9	positive selection	3852307
53326912	53326935	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTCTGTGTGGAGATGCGACGAGG	LRP8	ENSG00000157193	0.1069777756102519	[5]	[4,5]	2	hSpCas9	positive selection	3852308
53326882	53326905	1	-	26780180	A375	resistance to vemurafenib (Avana lentiGuide)	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.11236884453585257	[5]	[3,4]	-1	hSpCas9	positive selection	3852309
53280645	53280668	1	-	26780180	A375	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	0.952365103431064	[]	[]	4	hSpCas9	negative selection	3957956
53280630	53280653	1	+	26780180	A375	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	0.804358810305015	[]	[]	3	hSpCas9	negative selection	3957957
53326882	53326905	1	-	26780180	A375	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	0.735896851533529	[]	[]	2	hSpCas9	negative selection	3957958
53326939	53326962	1	+	26780180	A375	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	1.31949683167312	[]	[]	7	hSpCas9	negative selection	3957959
53280645	53280668	1	-	26780180	HT29	viability (GeCKOv2 library)	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	1.81440617760365	[]	[]	8	hSpCas9	negative selection	4065922
53280630	53280653	1	+	26780180	HT29	viability (GeCKOv2 library)	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	1.17970836050051	[]	[]	6	hSpCas9	negative selection	4065923
53326882	53326905	1	-	26780180	HT29	viability (GeCKOv2 library)	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	0.7807355480489	[]	[]	3	hSpCas9	negative selection	4065924
53326939	53326962	1	+	26780180	HT29	viability (GeCKOv2 library)	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	2.14834875358316	[]	[]	9	hSpCas9	negative selection	4065925
53326925	53326948	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	AGCGCTGCATCCCCTCTGTGTGG	LRP8	ENSG00000157193	0.007087441332146227	[6]	[4,3]	0	hSpCas9	positive selection	4149341
53326873	53326896	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiCRISPRv1)	GGCAGTCGTCCTCGTCGCTGTGG	LRP8	ENSG00000157193	0.054789587003282736	[5]	[3,4]	1	hSpCas9	positive selection	4149344
53326925	53326948	1	-	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	AGCGCTGCATCCCCTCTGTGTGG	LRP8	ENSG00000157193	0.30026144966633933	[5]	[5,3,5,0]	2	hSpCas9	positive selection	4213363
53326873	53326896	1	+	26780180	A375	resistance to vemurafenib (GeCKOv1 lentiGuide)	GGCAGTCGTCCTCGTCGCTGTGG	LRP8	ENSG00000157193	1.2791167160389603	[4]	[4,3,5,5]	9	hSpCas9	positive selection	4213366
53326939	53326962	1	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	-0.677745645756806	[2]	[0,0]	-9	hSpCas9	positive selection	4280893
53326882	53326905	1	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	0.46350508140647917	[4]	[4,4]	8	hSpCas9	positive selection	4280894
53280630	53280653	1	+	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	0.03356721367258042	[2]	[2,0]	0	hSpCas9	positive selection	4345152
53280645	53280668	1	-	26780180	A375	resistance to vemurafenib (GeCKOv2 lentiGuide)	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.03841064950125023	[1]	[1,0]	0	hSpCas9	positive selection	4345153
53271053	53271075	1	+	27760321	OCIAML3	viability	TAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	1.0335636178140295	[582,554]	[846,996]	9	hSpCas9	negative selection	4415169
53326914	53326936	1	+	27760321	OCIAML3	viability	TCGTCGCATCTCCACACAGAGG	LRP8	ENSG00000157193	0.015725818692904237	[699,602]	[461,580]	0	hSpCas9	negative selection	4415170
53326946	53326968	1	+	27760321	OCIAML3	viability	CTCGTTCCGGCACTGGAATTGG	LRP8	ENSG00000157193	-0.28594813004094677	[422,377]	[312,182]	-3	hSpCas9	negative selection	4415171
53266588	53266610	1	-	27760321	OCIAML3	viability	GAGGTGCGGAGGATCGACCTGG	LRP8	ENSG00000157193	0.4868861389778133	[442,433]	[453,517]	6	hSpCas9	negative selection	4415172
53271053	53271075	1	+	27760321	OCIAML2	viability	TAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	0.8020240806848482	[582,554]	[803,802]	9	hSpCas9	negative selection	4498632
53326914	53326936	1	+	27760321	OCIAML2	viability	TCGTCGCATCTCCACACAGAGG	LRP8	ENSG00000157193	-0.4186728173458474	[699,602]	[305,507]	-5	hSpCas9	negative selection	4498633
53326946	53326968	1	+	27760321	OCIAML2	viability	CTCGTTCCGGCACTGGAATTGG	LRP8	ENSG00000157193	0.1135804530374496	[422,377]	[340,361]	1	hSpCas9	negative selection	4498634
53266588	53266610	1	-	27760321	OCIAML2	viability	GAGGTGCGGAGGATCGACCTGG	LRP8	ENSG00000157193	-0.48626062613112486	[442,433]	[233,279]	-5	hSpCas9	negative selection	4498635
53271053	53271075	1	+	27760321	MV411	viability	TAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	0.7779433427081739	[582,554]	[463,915]	6	hSpCas9	negative selection	4582095
53326914	53326936	1	+	27760321	MV411	viability	TCGTCGCATCTCCACACAGAGG	LRP8	ENSG00000157193	0.0851802195324105	[699,602]	[435,482]	0	hSpCas9	negative selection	4582096
53326946	53326968	1	+	27760321	MV411	viability	CTCGTTCCGGCACTGGAATTGG	LRP8	ENSG00000157193	0.3423033106066019	[422,377]	[354,303]	2	hSpCas9	negative selection	4582097
53266588	53266610	1	-	27760321	MV411	viability	GAGGTGCGGAGGATCGACCTGG	LRP8	ENSG00000157193	0.6590721464073073	[442,433]	[270,738]	5	hSpCas9	negative selection	4582098
53271053	53271075	1	+	27760321	HL60	viability	TAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	-0.2629155007332375	[582,554]	[349,427]	-3	hSpCas9	negative selection	4665558
53326914	53326936	1	+	27760321	HL60	viability	TCGTCGCATCTCCACACAGAGG	LRP8	ENSG00000157193	0.6919154275540281	[699,602]	[866,846]	7	hSpCas9	negative selection	4665559
53326946	53326968	1	+	27760321	HL60	viability	CTCGTTCCGGCACTGGAATTGG	LRP8	ENSG00000157193	0.6202352822383259	[422,377]	[409,599]	7	hSpCas9	negative selection	4665560
53266588	53266610	1	-	27760321	HL60	viability	GAGGTGCGGAGGATCGACCTGG	LRP8	ENSG00000157193	-0.05515548766753782	[442,433]	[315,376]	0	hSpCas9	negative selection	4665561
53271053	53271075	1	+	27760321	HT1080	viability	TAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	1.2279852381156053	[554,432]	[417,507]	6	hSpCas9	negative selection	4749021
53326914	53326936	1	+	27760321	HT1080	viability	TCGTCGCATCTCCACACAGAGG	LRP8	ENSG00000157193	0.8226711216236159	[602,470]	[396,357]	4	hSpCas9	negative selection	4749022
53326946	53326968	1	+	27760321	HT1080	viability	CTCGTTCCGGCACTGGAATTGG	LRP8	ENSG00000157193	1.3922192426709215	[377,294]	[506,181]	7	hSpCas9	negative selection	4749023
53266588	53266610	1	-	27760321	HT1080	viability	GAGGTGCGGAGGATCGACCTGG	LRP8	ENSG00000157193	0.471075588422202	[433,338]	[327,87]	2	hSpCas9	negative selection	4749024
53271053	53271075	1	+	27760321	HT29	viability after 7 days	TAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	0.6369579500858842	[554,432]	[885,976,1080]	8	hSpCas9	negative selection	4832484
53326914	53326936	1	+	27760321	HT29	viability after 7 days	TCGTCGCATCTCCACACAGAGG	LRP8	ENSG00000157193	0.34716830579284463	[602,470]	[769,835,1007]	5	hSpCas9	negative selection	4832485
53326946	53326968	1	+	27760321	HT29	viability after 7 days	CTCGTTCCGGCACTGGAATTGG	LRP8	ENSG00000157193	-0.1730387833273231	[377,294]	[494,270,399]	-3	hSpCas9	negative selection	4832486
53266588	53266610	1	-	27760321	HT29	viability after 7 days	GAGGTGCGGAGGATCGACCTGG	LRP8	ENSG00000157193	0.1598342980800132	[433,338]	[531,560,567]	2	hSpCas9	negative selection	4832487
53271053	53271075	1	+	27760321	HT29	viability after 25 days	TAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	0.49316832155979323	[554,432]	[695,646,1074]	5	hSpCas9	negative selection	4915947
53326914	53326936	1	+	27760321	HT29	viability after 25 days	TCGTCGCATCTCCACACAGAGG	LRP8	ENSG00000157193	0.395108961070188	[602,470]	[660,781,1006]	4	hSpCas9	negative selection	4915948
53326946	53326968	1	+	27760321	HT29	viability after 25 days	CTCGTTCCGGCACTGGAATTGG	LRP8	ENSG00000157193	0.14923380584005935	[377,294]	[251,341,726]	1	hSpCas9	negative selection	4915949
53266588	53266610	1	-	27760321	HT29	viability after 25 days	GAGGTGCGGAGGATCGACCTGG	LRP8	ENSG00000157193	-0.19797100966698222	[433,338]	[247,506,410]	-2	hSpCas9	negative selection	4915950
53271053	53271075	1	+	27760321	HT29	viability after 22 days	TAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	0.5015261567151954	[554,432]	[860,647,915]	5	hSpCas9	negative selection	4999410
53326914	53326936	1	+	27760321	HT29	viability after 22 days	TCGTCGCATCTCCACACAGAGG	LRP8	ENSG00000157193	0.38691520743617924	[602,470]	[715,798,923]	4	hSpCas9	negative selection	4999411
53326946	53326968	1	+	27760321	HT29	viability after 22 days	CTCGTTCCGGCACTGGAATTGG	LRP8	ENSG00000157193	0.26026716095547153	[377,294]	[512,360,522]	2	hSpCas9	negative selection	4999412
53266588	53266610	1	-	27760321	HT29	viability after 22 days	GAGGTGCGGAGGATCGACCTGG	LRP8	ENSG00000157193	-0.15526669518028546	[433,338]	[428,368,404]	-1	hSpCas9	negative selection	4999413
53271053	53271075	1	+	27760321	HT29	viability after 19 days	TAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	0.8158348733856404	[554,432]	[1350,776,895]	8	hSpCas9	negative selection	5082873
53326914	53326936	1	+	27760321	HT29	viability after 19 days	TCGTCGCATCTCCACACAGAGG	LRP8	ENSG00000157193	0.32779851578941877	[602,470]	[826,694,794]	3	hSpCas9	negative selection	5082874
53326946	53326968	1	+	27760321	HT29	viability after 19 days	CTCGTTCCGGCACTGGAATTGG	LRP8	ENSG00000157193	0.6143330720367646	[377,294]	[672,652,454]	6	hSpCas9	negative selection	5082875
53266588	53266610	1	-	27760321	HT29	viability after 19 days	GAGGTGCGGAGGATCGACCTGG	LRP8	ENSG00000157193	0.22355972855340023	[433,338]	[346,388,783]	2	hSpCas9	negative selection	5082876
53271053	53271075	1	+	27760321	HT29	viability after 16 days	TAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	0.2705302178897037	[554,432]	[608,453,936]	3	hSpCas9	negative selection	5166336
53326914	53326936	1	+	27760321	HT29	viability after 16 days	TCGTCGCATCTCCACACAGAGG	LRP8	ENSG00000157193	0.24316314577442666	[602,470]	[965,494,701]	2	hSpCas9	negative selection	5166337
53326946	53326968	1	+	27760321	HT29	viability after 16 days	CTCGTTCCGGCACTGGAATTGG	LRP8	ENSG00000157193	0.30541674012045783	[377,294]	[505,445,447]	3	hSpCas9	negative selection	5166338
53266588	53266610	1	-	27760321	HT29	viability after 16 days	GAGGTGCGGAGGATCGACCTGG	LRP8	ENSG00000157193	0.35684167983137116	[433,338]	[320,564,752]	4	hSpCas9	negative selection	5166339
53271053	53271075	1	+	27760321	HT29	viability after 13 days	TAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	0.488660147194312	[554,432]	[797,908,710]	6	hSpCas9	negative selection	5249799
53326914	53326936	1	+	27760321	HT29	viability after 13 days	TCGTCGCATCTCCACACAGAGG	LRP8	ENSG00000157193	0.2646954301605652	[602,470]	[615,785,837]	3	hSpCas9	negative selection	5249800
53326946	53326968	1	+	27760321	HT29	viability after 13 days	CTCGTTCCGGCACTGGAATTGG	LRP8	ENSG00000157193	0.1360391948550963	[377,294]	[305,617,366]	1	hSpCas9	negative selection	5249801
53266588	53266610	1	-	27760321	HT29	viability after 13 days	GAGGTGCGGAGGATCGACCTGG	LRP8	ENSG00000157193	0.1069171221591287	[433,338]	[420,463,558]	1	hSpCas9	negative selection	5249802
53271053	53271075	1	+	27760321	HT29	viability after 10 days	TAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	0.14912629734215715	[554,432]	[833,702,518]	2	hSpCas9	negative selection	5333262
53326914	53326936	1	+	27760321	HT29	viability after 10 days	TCGTCGCATCTCCACACAGAGG	LRP8	ENSG00000157193	0.43165611055097564	[602,470]	[680,904,1121]	6	hSpCas9	negative selection	5333263
53326946	53326968	1	+	27760321	HT29	viability after 10 days	CTCGTTCCGGCACTGGAATTGG	LRP8	ENSG00000157193	0.10202419640356922	[377,294]	[634,554,171]	1	hSpCas9	negative selection	5333264
53266588	53266610	1	-	27760321	HT29	viability after 10 days	GAGGTGCGGAGGATCGACCTGG	LRP8	ENSG00000157193	0.10647514143333571	[433,338]	[337,508,706]	1	hSpCas9	negative selection	5333265
53271053	53271075	1	+	27760321	MOLM13	viability	TAGGTCCATCTCGTAGCCAGGG	LRP8	ENSG00000157193	-0.28746095944827965	[582,554]	[318,215]	-2	hSpCas9	negative selection	5416725
53326914	53326936	1	+	27760321	MOLM13	viability	TCGTCGCATCTCCACACAGAGG	LRP8	ENSG00000157193	-0.45458016729431694	[699,602]	[240,289]	-3	hSpCas9	negative selection	5416726
53326946	53326968	1	+	27760321	MOLM13	viability	CTCGTTCCGGCACTGGAATTGG	LRP8	ENSG00000157193	0.15762862201667108	[422,377]	[342,173]	1	hSpCas9	negative selection	5416727
53266588	53266610	1	-	27760321	MOLM13	viability	GAGGTGCGGAGGATCGACCTGG	LRP8	ENSG00000157193	0.6787209523123021	[442,433]	[719,121]	5	hSpCas9	negative selection	5416728
53327589	53327612	1	+	27661255	K562	viability	GGGCAGAGCCCTCAACACCGAGG	LRP8	ENSG00000157193	-0.06923743075396833	[812,774]	[590,616]	-3	dCas9-KRAB	negative selection	5490908
53327870	53327893	1	+	27661255	K562	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	-0.07340660328807797	[534,648]	[523,382]	-3	dCas9-KRAB	negative selection	5490909
53327694	53327717	1	-	27661255	K562	viability	GCGGGGAGGGGTCCAGAACCCGG	LRP8	ENSG00000157193	-0.11699322494720721	[229,239]	[186,160]	-4	dCas9-KRAB	negative selection	5490910
53326939	53326962	1	+	27260156	BXPC3	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.3143153857840624	[269]	[371,329,342,355]	6	hSpCas9	negative selection	5553353
53326882	53326905	1	-	27260156	BXPC3	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.03488910673051926	[1058]	[885,1117,1052,1304]	-1	hSpCas9	negative selection	5553354
53280630	53280653	1	+	27260156	BXPC3	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.30300984960496735	[197]	[166,137,153,218]	-6	hSpCas9	negative selection	5617612
53280645	53280668	1	-	27260156	BXPC3	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	0.1362522920039111	[180]	[200,265,157,200]	3	hSpCas9	negative selection	5617613
53326939	53326962	1	+	27260156	A673	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.15683881845675707	[269]	[409,305,460,268]	4	hSpCas9	negative selection	5674604
53326882	53326905	1	-	27260156	A673	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	0.004379800709832127	[1058]	[1160,1186,1252,1499]	0	hSpCas9	negative selection	5674605
53280630	53280653	1	+	27260156	A673	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	0.21994004186653937	[197]	[294,343,237,227]	5	hSpCas9	negative selection	5738863
53280645	53280668	1	-	27260156	A673	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.24032834255598634	[180]	[221,171,139,207]	-5	hSpCas9	negative selection	5738864
53326939	53326962	1	+	27260156	A375	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.09902366047780553	[269]	[358,298,454,242]	1	hSpCas9	negative selection	5795855
53326882	53326905	1	-	27260156	A375	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.2017039436278939	[1058]	[1011,1303,1120,911]	-3	hSpCas9	negative selection	5795856
53280630	53280653	1	+	27260156	A375	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	0.23045620195197025	[197]	[153,458,220,274]	3	hSpCas9	negative selection	5860114
53280645	53280668	1	-	27260156	A375	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	0.16458599592488787	[180]	[186,246,249,260]	2	hSpCas9	negative selection	5860115
53326939	53326962	1	+	27260156	COLO741	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	-0.035242787795393915	[269]	[472,217,329]	0	hSpCas9	negative selection	5917106
53326882	53326905	1	-	27260156	COLO741	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.07703294920242221	[1058]	[1558,1218,1103]	-2	hSpCas9	negative selection	5917107
53280630	53280653	1	+	27260156	COLO741	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.04487003170281145	[197]	[299,142,292]	-1	hSpCas9	negative selection	5981365
53280645	53280668	1	-	27260156	COLO741	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	0.3287592824277463	[180]	[275,281,309]	6	hSpCas9	negative selection	5981366
53326939	53326962	1	+	27260156	CAL120	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	-0.9138476066597587	[269]	[123,182,218]	-8	hSpCas9	negative selection	6038357
53326882	53326905	1	-	27260156	CAL120	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.33470005403829406	[1058]	[1165,961,1024]	-5	hSpCas9	negative selection	6038358
53280630	53280653	1	+	27260156	CAL120	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.3137609329952127	[197]	[274,179,151]	-4	hSpCas9	negative selection	6102616
53280645	53280668	1	-	27260156	CAL120	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.2434428664271544	[180]	[244,146,186]	-4	hSpCas9	negative selection	6102617
53326939	53326962	1	+	27260156	CADOES1	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	-0.08389755959562117	[269]	[222,212,215,297]	-1	hSpCas9	negative selection	6159608
53326882	53326905	1	-	27260156	CADOES1	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	0.02316996665448401	[1058]	[1188,1070,1053,676]	0	hSpCas9	negative selection	6159609
53280630	53280653	1	+	27260156	CADOES1	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.22376798688497002	[197]	[112,164,217,133]	-4	hSpCas9	negative selection	6223867
53280645	53280668	1	-	27260156	CADOES1	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.47856938979299013	[180]	[132,130,155,60]	-7	hSpCas9	negative selection	6223868
53326939	53326962	1	+	27260156	EWS502	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.32086760354606747	[269]	[315,288,343,495]	5	hSpCas9	negative selection	6280859
53326882	53326905	1	-	27260156	EWS502	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.1078751707757557	[1058]	[934,1057,1040,1144]	-2	hSpCas9	negative selection	6280860
53280630	53280653	1	+	27260156	EWS502	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	0.10926183774527076	[197]	[214,176,309,204]	2	hSpCas9	negative selection	6345118
53280645	53280668	1	-	27260156	EWS502	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.26088363816103044	[180]	[174,207,117,131]	-4	hSpCas9	negative selection	6345119
53326939	53326962	1	+	27260156	EW8	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	-0.030654666667598862	[269]	[205,300,207,141]	0	hSpCas9	negative selection	6402110
53326882	53326905	1	-	27260156	EW8	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.11914197434765028	[1058]	[606,852,809,864]	-2	hSpCas9	negative selection	6402111
53280630	53280653	1	+	27260156	EW8	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.12495770075790857	[197]	[115,210,147,109]	-2	hSpCas9	negative selection	6466369
53280645	53280668	1	-	27260156	EW8	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	0.3153598576576315	[180]	[175,193,73,302]	6	hSpCas9	negative selection	6466370
53326939	53326962	1	+	27260156	CORL105	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.30127799916080195	[269]	[528,398,407,229]	5	hSpCas9	negative selection	6523361
53326882	53326905	1	-	27260156	CORL105	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	0.07444188958846754	[1058]	[1284,1341,1337,1259]	1	hSpCas9	negative selection	6523362
53280630	53280653	1	+	27260156	CORL105	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	0.006014168520728669	[197]	[237,253,239,199]	0	hSpCas9	negative selection	6587620
53280645	53280668	1	-	27260156	CORL105	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.07286549277666743	[180]	[186,219,301,111]	-1	hSpCas9	negative selection	6587621
53326939	53326962	1	+	27260156	HS294T	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.38214616219362924	[269]	[115,151,146,128]	5	hSpCas9	negative selection	6644612
53326882	53326905	1	-	27260156	HS294T	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.09241056743813347	[1058]	[345,450,321,423]	-1	hSpCas9	negative selection	6644613
53280630	53280653	1	+	27260156	HS294T	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.5615614057780705	[197]	[65,40,38,61]	-7	hSpCas9	negative selection	6708871
53280645	53280668	1	-	27260156	HS294T	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-1.194506570866248	[180]	[21,33,35,30]	-9	hSpCas9	negative selection	6708872
53326939	53326962	1	+	27260156	HCC44	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.07214491748684881	[269]	[386,454,223,189]	1	hSpCas9	negative selection	6765863
53326882	53326905	1	-	27260156	HCC44	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.4413354941156329	[1058]	[722,791,1009,1011]	-6	hSpCas9	negative selection	6765864
53280630	53280653	1	+	27260156	HCC44	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.14210845746908007	[197]	[195,271,152,170]	-2	hSpCas9	negative selection	6830122
53280645	53280668	1	-	27260156	HCC44	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.5468242440391136	[180]	[108,65,207,193]	-7	hSpCas9	negative selection	6830123
53326939	53326962	1	+	27260156	G402	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.783186031136876	[269]	[509,285,557,871]	8	hSpCas9	negative selection	6887114
53326882	53326905	1	-	27260156	G402	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.11819259976462648	[1058]	[1368,1430,905,1095]	-1	hSpCas9	negative selection	6887115
53280630	53280653	1	+	27260156	G402	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.07231458398858992	[197]	[236,202,210,264]	-1	hSpCas9	negative selection	6951373
53280645	53280668	1	-	27260156	G402	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.7723503224742918	[180]	[184,42,167,123]	-7	hSpCas9	negative selection	6951374
53326939	53326962	1	+	27260156	L33	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	-0.07012843064602192	[269]	[192,120,205,214]	-1	hSpCas9	negative selection	7008365
53326882	53326905	1	-	27260156	L33	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.13495032221231495	[1058]	[1069,520,375,913]	-3	hSpCas9	negative selection	7008366
53280630	53280653	1	+	27260156	L33	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.07023401784504513	[197]	[149,85,95,241]	-1	hSpCas9	negative selection	7072624
53280645	53280668	1	-	27260156	L33	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.27468711009776814	[180]	[127,50,108,172]	-6	hSpCas9	negative selection	7072625
53326939	53326962	1	+	27260156	K562	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.4524709410874399	[269]	[668,280,193,205]	6	hSpCas9	negative selection	7129616
53326882	53326905	1	-	27260156	K562	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.2158250168791459	[1058]	[938,953,590,771]	-3	hSpCas9	negative selection	7129617
53280630	53280653	1	+	27260156	K562	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	0.10277634493178311	[197]	[94,58,184,377]	1	hSpCas9	negative selection	7193875
53280645	53280668	1	-	27260156	K562	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.34761682540601124	[180]	[114,202,67,121]	-4	hSpCas9	negative selection	7193876
53326939	53326962	1	+	27260156	HT29	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.0966704129597794	[269]	[499,280,339,292]	1	hSpCas9	negative selection	7250867
53326882	53326905	1	-	27260156	HT29	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.04031852804232372	[1058]	[1311,1262,1294,1146]	-1	hSpCas9	negative selection	7250868
53280630	53280653	1	+	27260156	HT29	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.04692820115728935	[197]	[181,83,292,340]	-1	hSpCas9	negative selection	7315126
53280645	53280668	1	-	27260156	HT29	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.18691522593549403	[180]	[202,163,182,216]	-4	hSpCas9	negative selection	7315127
53326939	53326962	1	+	27260156	MHHES1	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	-0.08688110800376003	[269]	[275,319,305,247]	-2	hSpCas9	negative selection	7372118
53326882	53326905	1	-	27260156	MHHES1	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.38847352523115897	[1058]	[885,1174,842,774]	-6	hSpCas9	negative selection	7372119
53280630	53280653	1	+	27260156	MHHES1	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.7472759437096983	[197]	[231,65,100,133]	-8	hSpCas9	negative selection	7436377
53280645	53280668	1	-	27260156	MHHES1	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.3745314574473988	[180]	[229,153,140,117]	-6	hSpCas9	negative selection	7436378
53326939	53326962	1	+	27260156	MEWO	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.32413729027578303	[269]	[317,311,318]	7	hSpCas9	negative selection	7493369
53326882	53326905	1	-	27260156	MEWO	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.049344503836457054	[1058]	[1091,791,1014]	-1	hSpCas9	negative selection	7493370
53280630	53280653	1	+	27260156	MEWO	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.06470306442105289	[197]	[163,129,234]	-1	hSpCas9	negative selection	7557628
53280645	53280668	1	-	27260156	MEWO	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	0.007154478323921021	[180]	[254,155,115]	0	hSpCas9	negative selection	7557629
53326939	53326962	1	+	27260156	LNCAPCLONEFGC	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.04557372059760667	[269]	[266,162,385,218]	0	hSpCas9	negative selection	7614620
53326882	53326905	1	-	27260156	LNCAPCLONEFGC	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.23062715630408415	[1058]	[860,748,1036,658]	-4	hSpCas9	negative selection	7614621
53280630	53280653	1	+	27260156	LNCAPCLONEFGC	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	0.33059213049444636	[197]	[278,187,228,207]	5	hSpCas9	negative selection	7678879
53280645	53280668	1	-	27260156	LNCAPCLONEFGC	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.1262244208791461	[180]	[197,142,93,156]	-2	hSpCas9	negative selection	7678880
53326939	53326962	1	+	27260156	PANC0327	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.19875493051270254	[269]	[179,297,186,424]	3	hSpCas9	negative selection	7735871
53326882	53326905	1	-	27260156	PANC0327	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.06469246855556343	[1058]	[879,710,824,1203]	-1	hSpCas9	negative selection	7735872
53280630	53280653	1	+	27260156	PANC0327	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.6047123321891403	[197]	[183,63,161,64]	-7	hSpCas9	negative selection	7800130
53280645	53280668	1	-	27260156	PANC0327	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.07795576550002625	[180]	[150,237,86,121]	-1	hSpCas9	negative selection	7800131
53326939	53326962	1	+	27260156	NCIH2009	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	-0.31255213779007907	[269]	[345,308,263]	-4	hSpCas9	negative selection	7857122
53326882	53326905	1	-	27260156	NCIH2009	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.2892331664250868	[1058]	[1211,1132,1286]	-4	hSpCas9	negative selection	7857123
53280630	53280653	1	+	27260156	NCIH2009	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	0.285905904802761	[197]	[409,425,187]	4	hSpCas9	negative selection	7921381
53280645	53280668	1	-	27260156	NCIH2009	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	0.34138241409186687	[180]	[488,263,241]	5	hSpCas9	negative selection	7921382
53326939	53326962	1	+	27260156	NCIH1373	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	-0.35042601100351756	[269]	[316,190,228,59]	-3	hSpCas9	negative selection	7978373
53326882	53326905	1	-	27260156	NCIH1373	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.48227978185204345	[1058]	[628,921,1131,170]	-5	hSpCas9	negative selection	7978374
53280630	53280653	1	+	27260156	NCIH1373	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.18106937644248422	[197]	[636,78,59,21]	-2	hSpCas9	negative selection	8042632
53280645	53280668	1	-	27260156	NCIH1373	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-1.7902628380158803	[180]	[63,29,40,27]	-9	hSpCas9	negative selection	8042633
53326939	53326962	1	+	27260156	PATU8902	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.16788237386008353	[269]	[707,292,340,352]	1	hSpCas9	negative selection	8099624
53326882	53326905	1	-	27260156	PATU8902	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	0.09434695780425728	[1058]	[1941,2137,1116,1153]	0	hSpCas9	negative selection	8099625
53280630	53280653	1	+	27260156	PATU8902	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.2181039903796611	[197]	[58,318,132,495]	-2	hSpCas9	negative selection	8163883
53280645	53280668	1	-	27260156	PATU8902	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.6954957597582008	[180]	[288,29,96,226]	-6	hSpCas9	negative selection	8163884
53326939	53326962	1	+	27260156	PANC1	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.10372314649069037	[269]	[220,394,233,183]	1	hSpCas9	negative selection	8220875
53326882	53326905	1	-	27260156	PANC1	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.1091928761325609	[1058]	[838,940,937,687]	-2	hSpCas9	negative selection	8220876
53280630	53280653	1	+	27260156	PANC1	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.7382635569677909	[197]	[85,112,168,49]	-8	hSpCas9	negative selection	8285134
53280645	53280668	1	-	27260156	PANC1	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.3075646828292258	[180]	[59,154,139,148]	-5	hSpCas9	negative selection	8285135
53326939	53326962	1	+	27260156	PANC0813	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.1944737854975529	[269]	[351,260,548,292]	3	hSpCas9	negative selection	8342126
53326882	53326905	1	-	27260156	PANC0813	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.051826223917592174	[1058]	[1402,1365,1117,943]	-1	hSpCas9	negative selection	8342127
53280630	53280653	1	+	27260156	PANC0813	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.06492425365847865	[197]	[215,322,196,155]	-1	hSpCas9	negative selection	8406385
53280645	53280668	1	-	27260156	PANC0813	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.1077466956208184	[180]	[128,212,160,274]	-2	hSpCas9	negative selection	8406386
53326939	53326962	1	+	27260156	RDES	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.15418591549336214	[269]	[253,295,317,560]	2	hSpCas9	negative selection	8463377
53326882	53326905	1	-	27260156	RDES	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.200965785853078	[1058]	[919,993,1078,1282]	-3	hSpCas9	negative selection	8463378
53280630	53280653	1	+	27260156	RDES	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	0.0483282799345377	[197]	[198,222,262,263]	0	hSpCas9	negative selection	8527636
53280645	53280668	1	-	27260156	RDES	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.38611582354777774	[180]	[202,123,158,134]	-6	hSpCas9	negative selection	8527637
53326939	53326962	1	+	27260156	PC3	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	-0.06718690517011838	[269]	[116,196,581,306]	-1	hSpCas9	negative selection	8584628
53326882	53326905	1	-	27260156	PC3	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.2056690036714489	[1058]	[548,778,1254,1310]	-5	hSpCas9	negative selection	8584629
53280630	53280653	1	+	27260156	PC3	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.006244410329559802	[197]	[95,166,441,207]	0	hSpCas9	negative selection	8648887
53280645	53280668	1	-	27260156	PC3	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.016492732764816997	[180]	[97,200,326,162]	0	hSpCas9	negative selection	8648888
53326939	53326962	1	+	27260156	PATU8988T	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.43444571067102017	[269]	[386,543,176,319]	7	hSpCas9	negative selection	8705879
53326882	53326905	1	-	27260156	PATU8988T	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	0.06824973690425473	[1058]	[1273,1206,874,939]	1	hSpCas9	negative selection	8705880
53280630	53280653	1	+	27260156	PATU8988T	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.0567704199529826	[197]	[75,203,285,168]	-1	hSpCas9	negative selection	8770138
53280645	53280668	1	-	27260156	PATU8988T	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.3526664742180112	[180]	[160,182,62,146]	-5	hSpCas9	negative selection	8770139
53326939	53326962	1	+	27260156	T47D	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.13082471181778654	[269]	[356,393,283,338]	2	hSpCas9	negative selection	8827130
53326882	53326905	1	-	27260156	T47D	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	0.012270963628792098	[1058]	[1211,1224,1322,1215]	0	hSpCas9	negative selection	8827131
53280630	53280653	1	+	27260156	T47D	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	0.13566596209715054	[197]	[264,238,232,278]	3	hSpCas9	negative selection	8891389
53280645	53280668	1	-	27260156	T47D	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.05063179246378113	[180]	[187,164,253,209]	-1	hSpCas9	negative selection	8891390
53326939	53326962	1	+	27260156	SU8686	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.2680301491929923	[269]	[244,218,416,451]	4	hSpCas9	negative selection	8948381
53326882	53326905	1	-	27260156	SU8686	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	0.0884306302416431	[1058]	[920,949,1339,1330]	1	hSpCas9	negative selection	8948382
53280630	53280653	1	+	27260156	SU8686	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	-0.0663157385797899	[197]	[201,166,153,232]	-1	hSpCas9	negative selection	9012640
53280645	53280668	1	-	27260156	SU8686	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.05278218138041879	[180]	[118,164,179,245]	-1	hSpCas9	negative selection	9012641
53326939	53326962	1	+	27260156	SKES1	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	-0.088287250946125	[269]	[290,310,251,177]	-2	hSpCas9	negative selection	9069632
53326882	53326905	1	-	27260156	SKES1	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.2351509155870769	[1058]	[968,941,734,945]	-5	hSpCas9	negative selection	9069633
53280630	53280653	1	+	27260156	SKES1	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	0.05845844480393114	[197]	[248,210,174,193]	1	hSpCas9	negative selection	9133891
53280645	53280668	1	-	27260156	SKES1	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.2579787479359801	[180]	[237,143,96,136]	-5	hSpCas9	negative selection	9133892
53326939	53326962	1	+	27260156	TOV112D	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.05628337391984317	[269]	[370,320,363,90]	1	hSpCas9	negative selection	9190883
53326882	53326905	1	-	27260156	TOV112D	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.052415439729889046	[1058]	[1116,1004,1018,953]	-1	hSpCas9	negative selection	9190884
53280630	53280653	1	+	27260156	TOV112D	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	0.05092864322086221	[197]	[196,262,174,199]	1	hSpCas9	negative selection	9255142
53280645	53280668	1	-	27260156	TOV112D	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.053358874268418566	[180]	[111,480,123,54]	-1	hSpCas9	negative selection	9255143
53326939	53326962	1	+	27260156	TC71	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.19602828572719955	[269]	[329,270,363,361]	5	hSpCas9	negative selection	9312134
53326882	53326905	1	-	27260156	TC71	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.08037651325608408	[1058]	[1005,1156,955,1187]	-2	hSpCas9	negative selection	9312135
53280630	53280653	1	+	27260156	TC71	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	0.08039901758539991	[197]	[256,189,213,236]	2	hSpCas9	negative selection	9376393
53280645	53280668	1	-	27260156	TC71	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	0.09337935857943225	[180]	[193,199,172,265]	2	hSpCas9	negative selection	9376394
53326939	53326962	1	+	27260156	TC32	viability	TGCAGCGCTCGTTCCGGCACTGG	LRP8	ENSG00000157193	0.012524583081708895	[269]	[320,180,283,245]	0	hSpCas9	negative selection	9433385
53326882	53326905	1	-	27260156	TC32	viability	CTGCTTAGACCACAGCGACGAGG	LRP8	ENSG00000157193	-0.10448584412777762	[1058]	[941,747,1189,872]	-2	hSpCas9	negative selection	9433386
53280630	53280653	1	+	27260156	TC32	viability	CTCCCCGTCGCAGCGCCACGAGG	LRP8	ENSG00000157193	0.07181526341261213	[197]	[100,63,360,346]	1	hSpCas9	negative selection	9497644
53280645	53280668	1	-	27260156	TC32	viability	ACAAGTGTGTACCTGCCTCGTGG	LRP8	ENSG00000157193	-0.3658663352416345	[180]	[115,149,106,136]	-6	hSpCas9	negative selection	9497645
53271051	53271074	1	+	27869803	HPAFII	viability after 27 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	1.0096433078834535	[72]	[37,109,NaN]	8	hSpCas9	negative selection	9535035
53271328	53271351	1	+	27869803	HPAFII	viability after 27 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.7382053755062703	[286]	[192,4,NaN]	-5	hSpCas9	negative selection	9535036
53274723	53274746	1	-	27869803	HPAFII	viability after 27 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	1.2157058411723276	[379]	[397,518,NaN]	8	hSpCas9	negative selection	9535037
53277011	53277034	1	+	27869803	HPAFII	viability after 27 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	0.20511442990461248	[446]	[505,74,NaN]	1	hSpCas9	negative selection	9535038
53326915	53326938	1	+	27869803	HPAFII	viability after 27 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	-0.1041654550066371	[943]	[614,333,NaN]	-1	hSpCas9	negative selection	9535039
53271051	53271074	1	+	27869803	HPAFII	viability after 15 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	0.6560330226782403	[72]	[40,174,NaN]	7	hSpCas9	negative selection	9617484
53271328	53271351	1	+	27869803	HPAFII	viability after 15 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.20460975362818934	[286]	[398,185,NaN]	-2	hSpCas9	negative selection	9617485
53274723	53274746	1	-	27869803	HPAFII	viability after 15 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.37526821078138317	[379]	[435,587,NaN]	4	hSpCas9	negative selection	9617486
53277011	53277034	1	+	27869803	HPAFII	viability after 15 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	0.49141607338710125	[446]	[995,475,NaN]	5	hSpCas9	negative selection	9617487
53326915	53326938	1	+	27869803	HPAFII	viability after 15 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	-0.5334739694705266	[943]	[925,560,NaN]	-5	hSpCas9	negative selection	9617488
53271051	53271074	1	+	27869803	ASPC1	viability after 36 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	0.9645314670452014	[311]	[247,270,138]	8	hSpCas9	negative selection	9699933
53271328	53271351	1	+	27869803	ASPC1	viability after 36 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.9745377188689588	[890]	[164,234,90]	-7	hSpCas9	negative selection	9699934
53274723	53274746	1	-	27869803	ASPC1	viability after 36 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.7176582428384228	[831]	[1002,265,271]	7	hSpCas9	negative selection	9699935
53277011	53277034	1	+	27869803	ASPC1	viability after 36 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	0.11316068410466007	[919]	[354,474,236]	1	hSpCas9	negative selection	9699936
53326915	53326938	1	+	27869803	ASPC1	viability after 36 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	-0.11850963298055928	[2144]	[1196,925,138]	-1	hSpCas9	negative selection	9699937
53271051	53271074	1	+	27869803	PATU8988S	viability after 35 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	0.4106263113455493	[298]	[191,127,NaN]	4	hSpCas9	negative selection	9782382
53271328	53271351	1	+	27869803	PATU8988S	viability after 35 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	0.3030282545238362	[805]	[395,404,NaN]	3	hSpCas9	negative selection	9782383
53274723	53274746	1	-	27869803	PATU8988S	viability after 35 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.31760836388218705	[662]	[455,208,NaN]	3	hSpCas9	negative selection	9782384
53277011	53277034	1	+	27869803	PATU8988S	viability after 35 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	0.5614228649182497	[849]	[590,418,NaN]	6	hSpCas9	negative selection	9782385
53326915	53326938	1	+	27869803	PATU8988S	viability after 35 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	-0.05008580979986199	[1950]	[738,778,NaN]	0	hSpCas9	negative selection	9782386
53271051	53271074	1	+	27869803	PATU8988S	viability after 31 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	-0.22851286098557455	[298]	[99,103,NaN]	-3	hSpCas9	negative selection	9864831
53271328	53271351	1	+	27869803	PATU8988S	viability after 31 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.10891249600486375	[805]	[191,432,NaN]	-1	hSpCas9	negative selection	9864832
53274723	53274746	1	-	27869803	PATU8988S	viability after 31 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	0.369272051191465	[662]	[355,322,NaN]	4	hSpCas9	negative selection	9864833
53277011	53277034	1	+	27869803	PATU8988S	viability after 31 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	0.376232751261265	[849]	[420,463,NaN]	4	hSpCas9	negative selection	9864834
53326915	53326938	1	+	27869803	PATU8988S	viability after 31 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	-0.10317899720841606	[1950]	[597,884,NaN]	-1	hSpCas9	negative selection	9864835
53271051	53271074	1	+	27869803	HPAFII	viability after 35 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	-0.16368752501261952	[72]	[16,50,NaN]	-1	hSpCas9	negative selection	9947280
53271328	53271351	1	+	27869803	HPAFII	viability after 35 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-1.7136994337994618	[286]	[48,38,NaN]	-7	hSpCas9	negative selection	9947281
53274723	53274746	1	-	27869803	HPAFII	viability after 35 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	1.7784255541824534	[379]	[420,928,NaN]	9	hSpCas9	negative selection	9947282
53277011	53277034	1	+	27869803	HPAFII	viability after 35 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	0.2745945697769322	[446]	[451,72,NaN]	1	hSpCas9	negative selection	9947283
53326915	53326938	1	+	27869803	HPAFII	viability after 35 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	-0.4903922717616793	[943]	[231,461,NaN]	-3	hSpCas9	negative selection	9947284
53271051	53271074	1	+	27869803	HPAFII	viability after 31 days	AGTAGGTCCATCTCGTAGCCAGG	LRP8	ENSG00000157193	0.0890936391879047	[72]	[22,65,NaN]	0	hSpCas9	negative selection	10029729
53271328	53271351	1	+	27869803	HPAFII	viability after 31 days	TGCAGACACTCGTTCAGCCCTGG	LRP8	ENSG00000157193	-0.9245715282572682	[286]	[103,63,NaN]	-5	hSpCas9	negative selection	10029730
53274723	53274746	1	-	27869803	HPAFII	viability after 31 days	TGCAGAGGGACTGCCGGGACTGG	LRP8	ENSG00000157193	1.07780049288529	[379]	[274,640,NaN]	7	hSpCas9	negative selection	10029731
53277011	53277034	1	+	27869803	HPAFII	viability after 31 days	GCCGTCGCACACGAACACGGCGG	LRP8	ENSG00000157193	-0.06976366830592051	[446]	[339,128,NaN]	0	hSpCas9	negative selection	10029732
53326915	53326938	1	+	27869803	HPAFII	viability after 31 days	CGTCGCATCTCCACACAGAGGGG	LRP8	ENSG00000157193	-0.3109382761839736	[943]	[383,473,NaN]	-2	hSpCas9	negative selection	10029733
53280616	53280639	1	-	28162770	P31FUJ	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	-0.42872241438963554	[62]	[54]	-4	hSpCas9	negative selection	10185873
53262500	53262523	1	-	28162770	P31FUJ	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	0.4318491849359375	[134]	[213]	5	hSpCas9	negative selection	10185874
53327870	53327893	1	+	28162770	P31FUJ	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	-0.984874690970793	[95]	[56]	-6	hSpCas9	negative selection	10185875
53327819	53327842	1	-	28162770	P31FUJ	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	0.3817045719207929	[144]	[221]	4	hSpCas9	negative selection	10185876
53327794	53327817	1	-	28162770	P31FUJ	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.7860568228369372	[151]	[307]	8	hSpCas9	negative selection	10185877
53327785	53327808	1	+	28162770	P31FUJ	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	-0.3745303140260391	[170]	[154]	-3	hSpCas9	negative selection	10185878
53271316	53271339	1	-	28162770	P31FUJ	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	0.1315729362516468	[354]	[456]	1	hSpCas9	negative selection	10185879
53266598	53266621	1	-	28162770	P31FUJ	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	0.9124607427936645	[117]	[260]	9	hSpCas9	negative selection	10185880
53264157	53264180	1	+	28162770	P31FUJ	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	-0.631537891364122	[351]	[266]	-5	hSpCas9	negative selection	10185881
53280616	53280639	1	-	28162770	TF1	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	NaN	[NaN]	[17]	1	hSpCas9	negative selection	10355239
53262500	53262523	1	-	28162770	TF1	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	NaN	[NaN]	[33]	1	hSpCas9	negative selection	10355240
53327870	53327893	1	+	28162770	TF1	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	NaN	[NaN]	[79]	1	hSpCas9	negative selection	10355241
53327819	53327842	1	-	28162770	TF1	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	NaN	[NaN]	[91]	1	hSpCas9	negative selection	10355242
53327794	53327817	1	-	28162770	TF1	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	NaN	[NaN]	[258]	1	hSpCas9	negative selection	10355243
53327785	53327808	1	+	28162770	TF1	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	NaN	[NaN]	[20]	1	hSpCas9	negative selection	10355244
53271316	53271339	1	-	28162770	TF1	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	NaN	[NaN]	[334]	1	hSpCas9	negative selection	10355245
53266598	53266621	1	-	28162770	TF1	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	NaN	[NaN]	[146]	1	hSpCas9	negative selection	10355246
53264157	53264180	1	+	28162770	TF1	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	NaN	[NaN]	[63]	1	hSpCas9	negative selection	10355247
53280616	53280639	1	-	28162770	SKM1	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	0.23244608600037076	[12]	[26]	2	hSpCas9	negative selection	10524605
53262500	53262523	1	-	28162770	SKM1	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	0.1414724259528804	[39]	[77]	1	hSpCas9	negative selection	10524606
53327870	53327893	1	+	28162770	SKM1	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	0.20902519759861904	[22]	[46]	2	hSpCas9	negative selection	10524607
53327819	53327842	1	-	28162770	SKM1	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	-0.6731383121075227	[45]	[50]	-5	hSpCas9	negative selection	10524608
53327794	53327817	1	-	28162770	SKM1	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.11211036632153742	[55]	[106]	1	hSpCas9	negative selection	10524609
53327785	53327808	1	+	28162770	SKM1	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	-0.36257007938470825	[55]	[76]	-3	hSpCas9	negative selection	10524610
53271316	53271339	1	-	28162770	SKM1	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	0.6448747327764561	[122]	[339]	6	hSpCas9	negative selection	10524611
53266598	53266621	1	-	28162770	SKM1	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	-0.21056698593965828	[35]	[54]	-2	hSpCas9	negative selection	10524612
53264157	53264180	1	+	28162770	SKM1	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	-0.6828389503503802	[78]	[86]	-5	hSpCas9	negative selection	10524613
53280616	53280639	1	-	28162770	SKM1	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	0.23244608600037076	[12]	[26]	2	hSpCas9	negative selection	10693971
53262500	53262523	1	-	28162770	SKM1	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	0.1414724259528804	[39]	[77]	1	hSpCas9	negative selection	10693972
53327870	53327893	1	+	28162770	SKM1	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	0.20902519759861904	[22]	[46]	2	hSpCas9	negative selection	10693973
53327819	53327842	1	-	28162770	SKM1	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	-0.6731383121075227	[45]	[50]	-5	hSpCas9	negative selection	10693974
53327794	53327817	1	-	28162770	SKM1	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.11211036632153742	[55]	[106]	1	hSpCas9	negative selection	10693975
53327785	53327808	1	+	28162770	SKM1	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	-0.36257007938470825	[55]	[76]	-3	hSpCas9	negative selection	10693976
53271316	53271339	1	-	28162770	SKM1	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	0.6448747327764561	[122]	[339]	6	hSpCas9	negative selection	10693977
53266598	53266621	1	-	28162770	SKM1	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	-0.21056698593965828	[35]	[54]	-2	hSpCas9	negative selection	10693978
53264157	53264180	1	+	28162770	SKM1	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	-0.6828389503503802	[78]	[86]	-5	hSpCas9	negative selection	10693979
53280616	53280639	1	-	28162770	PL21	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	0.2228596909894036	[62]	[31]	2	hSpCas9	negative selection	10863337
53262500	53262523	1	-	28162770	PL21	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	0.3221301388679305	[135]	[73]	3	hSpCas9	negative selection	10863338
53327870	53327893	1	+	28162770	PL21	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	0.03412966305039089	[91]	[40]	0	hSpCas9	negative selection	10863339
53327819	53327842	1	-	28162770	PL21	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	-0.7123975442603405	[127]	[33]	-5	hSpCas9	negative selection	10863340
53327794	53327817	1	-	28162770	PL21	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.5393457008085181	[165]	[104]	5	hSpCas9	negative selection	10863341
53327785	53327808	1	+	28162770	PL21	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	0.3357947138468866	[141]	[77]	3	hSpCas9	negative selection	10863342
53271316	53271339	1	-	28162770	PL21	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	-0.5622191371052837	[362]	[106]	-4	hSpCas9	negative selection	10863343
53266598	53266621	1	-	28162770	PL21	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	-0.1361437733751123	[100]	[39]	-1	hSpCas9	negative selection	10863344
53264157	53264180	1	+	28162770	PL21	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	-0.22870368431455435	[244]	[90]	-2	hSpCas9	negative selection	10863345
53280616	53280639	1	-	28162770	P31FUJ	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	-0.42872241438963554	[62]	[54]	-4	hSpCas9	negative selection	11032703
53262500	53262523	1	-	28162770	P31FUJ	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	0.4318491849359375	[134]	[213]	5	hSpCas9	negative selection	11032704
53327870	53327893	1	+	28162770	P31FUJ	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	-0.984874690970793	[95]	[56]	-6	hSpCas9	negative selection	11032705
53327819	53327842	1	-	28162770	P31FUJ	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	0.3817045719207929	[144]	[221]	4	hSpCas9	negative selection	11032706
53327794	53327817	1	-	28162770	P31FUJ	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.7860568228369372	[151]	[307]	8	hSpCas9	negative selection	11032707
53327785	53327808	1	+	28162770	P31FUJ	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	-0.3745303140260391	[170]	[154]	-3	hSpCas9	negative selection	11032708
53271316	53271339	1	-	28162770	P31FUJ	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	0.1315729362516468	[354]	[456]	1	hSpCas9	negative selection	11032709
53266598	53266621	1	-	28162770	P31FUJ	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	0.9124607427936645	[117]	[260]	9	hSpCas9	negative selection	11032710
53264157	53264180	1	+	28162770	P31FUJ	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	-0.631537891364122	[351]	[266]	-5	hSpCas9	negative selection	11032711
53280616	53280639	1	-	28162770	OCIAML5	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	-1.8520665708639967	[25]	[12]	-7	hSpCas9	negative selection	11202069
53262500	53262523	1	-	28162770	OCIAML5	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	-0.06820000172876256	[114]	[197]	0	hSpCas9	negative selection	11202070
53327870	53327893	1	+	28162770	OCIAML5	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	-0.8005362702239152	[54]	[56]	-5	hSpCas9	negative selection	11202071
53327819	53327842	1	-	28162770	OCIAML5	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	-0.06038380698872213	[118]	[205]	0	hSpCas9	negative selection	11202072
53327794	53327817	1	-	28162770	OCIAML5	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.9123797597243162	[77]	[264]	7	hSpCas9	negative selection	11202073
53327785	53327808	1	+	28162770	OCIAML5	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	0.19651360958106467	[72]	[150]	1	hSpCas9	negative selection	11202074
53271316	53271339	1	-	28162770	OCIAML5	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	0.4327722052881454	[196]	[479]	4	hSpCas9	negative selection	11202075
53266598	53266621	1	-	28162770	OCIAML5	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	0.07198457590270446	[77]	[147]	0	hSpCas9	negative selection	11202076
53264157	53264180	1	+	28162770	OCIAML5	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	0.04021961183574965	[138]	[257]	0	hSpCas9	negative selection	11202077
53280616	53280639	1	-	28162770	EOL1	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	-0.772525095472159	[106]	[32]	-5	hSpCas9	negative selection	11371435
53262500	53262523	1	-	28162770	EOL1	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	1.2210790893924155	[148]	[182]	8	hSpCas9	negative selection	11371436
53327870	53327893	1	+	28162770	EOL1	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	-0.16856163282094694	[191]	[89]	-1	hSpCas9	negative selection	11371437
53327819	53327842	1	-	28162770	EOL1	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	-0.011973171605065315	[288]	[150]	0	hSpCas9	negative selection	11371438
53327794	53327817	1	-	28162770	EOL1	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	-0.334838857248115	[236]	[98]	-3	hSpCas9	negative selection	11371439
53327785	53327808	1	+	28162770	EOL1	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	0.2910223054111588	[286]	[184]	2	hSpCas9	negative selection	11371440
53271316	53271339	1	-	28162770	EOL1	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	0.3892160385739789	[399]	[275]	3	hSpCas9	negative selection	11371441
53266598	53266621	1	-	28162770	EOL1	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	-0.6383884228206227	[129]	[43]	-4	hSpCas9	negative selection	11371442
53264157	53264180	1	+	28162770	EOL1	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	0.04568420907216943	[273]	[148]	0	hSpCas9	negative selection	11371443
53280616	53280639	1	-	28162770	MOLM13	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	-0.8540387133427836	[99]	[39]	-5	hSpCas9	negative selection	11540801
53262500	53262523	1	-	28162770	MOLM13	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	0.7012030892583729	[187]	[220]	5	hSpCas9	negative selection	11540802
53327870	53327893	1	+	28162770	MOLM13	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	0.4307363831271125	[117]	[114]	3	hSpCas9	negative selection	11540803
53327819	53327842	1	-	28162770	MOLM13	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	-0.4174680525142985	[265]	[143]	-2	hSpCas9	negative selection	11540804
53327794	53327817	1	-	28162770	MOLM13	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.992006327045208	[225]	[324]	7	hSpCas9	negative selection	11540805
53327785	53327808	1	+	28162770	MOLM13	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	0.9445659466158085	[188]	[262]	7	hSpCas9	negative selection	11540806
53271316	53271339	1	-	28162770	MOLM13	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	0.7153584842314964	[496]	[589]	5	hSpCas9	negative selection	11540807
53266598	53266621	1	-	28162770	MOLM13	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	-0.35027229546960825	[133]	[75]	-2	hSpCas9	negative selection	11540808
53264157	53264180	1	+	28162770	MOLM13	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	-0.8958012377340447	[367]	[142]	-5	hSpCas9	negative selection	11540809
53280616	53280639	1	-	28162770	HEL	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	0.19913218052474235	[101]	[74]	1	hSpCas9	negative selection	11710167
53262500	53262523	1	-	28162770	HEL	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	-0.5499062459420391	[159]	[69]	-4	hSpCas9	negative selection	11710168
53327870	53327893	1	+	28162770	HEL	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	0.4629177944155446	[127]	[112]	4	hSpCas9	negative selection	11710169
53327819	53327842	1	-	28162770	HEL	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	0.5572694898110075	[225]	[212]	5	hSpCas9	negative selection	11710170
53327794	53327817	1	-	28162770	HEL	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.860045964177022	[202]	[235]	7	hSpCas9	negative selection	11710171
53327785	53327808	1	+	28162770	HEL	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	0.41901735019138925	[180]	[154]	3	hSpCas9	negative selection	11710172
53271316	53271339	1	-	28162770	HEL	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	0.01600880004227412	[402]	[260]	0	hSpCas9	negative selection	11710173
53266598	53266621	1	-	28162770	HEL	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	0.955896717259987	[98]	[122]	8	hSpCas9	negative selection	11710174
53264157	53264180	1	+	28162770	HEL	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	0.22770133272151322	[327]	[245]	1	hSpCas9	negative selection	11710175
53280616	53280639	1	-	28162770	MV411	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	-1.5046349357736395	[63]	[18]	-7	hSpCas9	negative selection	11879533
53262500	53262523	1	-	28162770	MV411	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	-0.2092008529628414	[128]	[93]	-2	hSpCas9	negative selection	11879534
53327870	53327893	1	+	28162770	MV411	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	1.1734369693389983	[69]	[132]	9	hSpCas9	negative selection	11879535
53327819	53327842	1	-	28162770	MV411	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	-0.6423795314668017	[188]	[101]	-4	hSpCas9	negative selection	11879536
53327794	53327817	1	-	28162770	MV411	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.11093555087791326	[143]	[130]	0	hSpCas9	negative selection	11879537
53327785	53327808	1	+	28162770	MV411	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	0.1584325447240304	[116]	[109]	1	hSpCas9	negative selection	11879538
53271316	53271339	1	-	28162770	MV411	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	-0.3353668417709722	[333]	[222]	-3	hSpCas9	negative selection	11879539
53266598	53266621	1	-	28162770	MV411	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	1.3565592731628877	[69]	[150]	9	hSpCas9	negative selection	11879540
53264157	53264180	1	+	28162770	MV411	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	-1.9833426560463918	[229]	[48]	-8	hSpCas9	negative selection	11879541
53280616	53280639	1	-	28162770	MONOMAC1	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	-1.2443425618379103	[61]	[29]	-7	hSpCas9	negative selection	12048899
53262500	53262523	1	-	28162770	MONOMAC1	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	-0.47079765948640584	[80]	[66]	-4	hSpCas9	negative selection	12048900
53327870	53327893	1	+	28162770	MONOMAC1	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	-0.6665221303607739	[71]	[51]	-5	hSpCas9	negative selection	12048901
53327819	53327842	1	-	28162770	MONOMAC1	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	2.6315736350381016	[76]	[546]	9	hSpCas9	negative selection	12048902
53327794	53327817	1	-	28162770	MONOMAC1	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	1.017557203716487	[105]	[245]	8	hSpCas9	negative selection	12048903
53327785	53327808	1	+	28162770	MONOMAC1	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	0.7878562605502378	[95]	[189]	7	hSpCas9	negative selection	12048904
53271316	53271339	1	-	28162770	MONOMAC1	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	-0.1381431580059852	[215]	[224]	-1	hSpCas9	negative selection	12048905
53266598	53266621	1	-	28162770	MONOMAC1	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	-0.6202482777840979	[58]	[43]	-5	hSpCas9	negative selection	12048906
53264157	53264180	1	+	28162770	MONOMAC1	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	-0.06830353293735095	[149]	[163]	0	hSpCas9	negative selection	12048907
53280616	53280639	1	-	28162770	OCIAML2	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	-0.25561693427131105	[13]	[64]	-2	hSpCas9	negative selection	12218265
53262500	53262523	1	-	28162770	OCIAML2	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	0.1334414984266995	[24]	[151]	1	hSpCas9	negative selection	12218266
53327870	53327893	1	+	28162770	OCIAML2	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	-0.12748524444510306	[26]	[136]	-1	hSpCas9	negative selection	12218267
53327819	53327842	1	-	28162770	OCIAML2	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	0.8578411155119731	[21]	[220]	8	hSpCas9	negative selection	12218268
53327794	53327817	1	-	28162770	OCIAML2	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	1.2174261684430987	[17]	[231]	9	hSpCas9	negative selection	12218269
53327785	53327808	1	+	28162770	OCIAML2	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	0.7871679322254855	[22]	[219]	7	hSpCas9	negative selection	12218270
53271316	53271339	1	-	28162770	OCIAML2	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	-0.35673885871417677	[69]	[302]	-3	hSpCas9	negative selection	12218271
53266598	53266621	1	-	28162770	OCIAML2	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	-0.22777330134599771	[14]	[70]	-2	hSpCas9	negative selection	12218272
53264157	53264180	1	+	28162770	OCIAML2	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	-0.996698636909749	[53]	[149]	-6	hSpCas9	negative selection	12218273
53280616	53280639	1	-	28162770	OCIAML3	viability	GACGGGGAGAAGGACTGCGAGGG	LRP8	ENSG00000157193	-0.2985517567979916	[10]	[26]	-2	hSpCas9	negative selection	12387631
53262500	53262523	1	-	28162770	OCIAML3	viability	GAAATCTGGGCTCAACGGTGTGG	LRP8	ENSG00000157193	0.6354742057986041	[28]	[135]	6	hSpCas9	negative selection	12387632
53327870	53327893	1	+	28162770	OCIAML3	viability	GCAGCGCCAGAAGCCGGAGAGGG	LRP8	ENSG00000157193	0.4059923596758369	[21]	[87]	4	hSpCas9	negative selection	12387633
53327819	53327842	1	-	28162770	OCIAML3	viability	GCAGCTCCAGCATCTTGCGGCGG	LRP8	ENSG00000157193	-0.16774288562206524	[47]	[128]	-1	hSpCas9	negative selection	12387634
53327794	53327817	1	-	28162770	OCIAML3	viability	GCGGCTGATCCGCTGCTCGGCGG	LRP8	ENSG00000157193	0.12544019258401354	[57]	[190]	1	hSpCas9	negative selection	12387635
53327785	53327808	1	+	28162770	OCIAML3	viability	GCACCTTGGCCGCCGAGCAGCGG	LRP8	ENSG00000157193	0.606131974165157	[41]	[192]	5	hSpCas9	negative selection	12387636
53271316	53271339	1	-	28162770	OCIAML3	viability	GAGTGTCTGCACAACAATGGCGG	LRP8	ENSG00000157193	-0.1808696739608009	[94]	[252]	-1	hSpCas9	negative selection	12387637
53266598	53266621	1	-	28162770	OCIAML3	viability	CCAACCGGCACGAGGTGCGGAGG	LRP8	ENSG00000157193	0.22799405769784242	[27]	[98]	2	hSpCas9	negative selection	12387638
53264157	53264180	1	+	28162770	OCIAML3	viability	TGGGACACTCACCCTCGCAGGGG	LRP8	ENSG00000157193	-0.5729460247963334	[67]	[137]	-4	hSpCas9	negative selection	12387639